DT-Web

DB03566 - Spermidine


Identification
Name Spermidine
Accession Number DB03566 (EXPT02942)
Type small molecule
Description Spermidine is a polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 145.2459
Groups experimental
Monoisotopic Weight 145.157897623
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Spermidine/putrescine-binding periplasmic protein precursor
Name Spermidine/putrescine-binding periplasmic protein precursor
Gene Name potD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7063
Thioredoxin reductase 1, cytoplasmic
Name Thioredoxin reductase 1, cytoplasmic
Gene Name TXNRD1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8932
Gentamicin 3'-acetyltransferase
Name Gentamicin 3'-acetyltransferase
Gene Name aacC1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score Not Available

Transporters


Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score 0.3786
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate
References
  • Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H: Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem. 1996 Dec 20;271(51):32599-604. - Pubmed
DTHybrid score 0.4006

Predictions


Id Partner name Gene Name Score
118 Organic cation/carnitine transporter 2 SLC22A5 0.0911
6144 Solute carrier family 22 member 2 SLC22A2 0.0908
2826 Glucose--fructose oxidoreductase gfo 0.0557
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0557
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0557
2675 Pteridine reductase 1 PTR1 0.0545
6147 Solute carrier family 22 member 3 SLC22A3 0.0538
4119 Cytochrome P450 2D6 CYP2D6 0.0511
1588 Multidrug resistance protein 1 ABCB1 0.0471
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0467
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0461
4512 Cytochrome P450 3A4 CYP3A4 0.046
6142 Solute carrier family 22 member 8 SLC22A8 0.033
4200 Cytochrome P450 1A2 CYP1A2 0.033
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.028
1569 G1/S-specific cyclin-D1 CCND1 0.0263
6024 Cytochrome P450 1A1 CYP1A1 0.0247
4579 Serine acetyltransferase cysE 0.0239
6807 Serine acetyltransferase cysE 0.0239
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.0239
4564 YvbK protein yvbK 0.0239
4576 Aac(6')-Ii protein aac(6')-Ii 0.0239
4566 Acyl-CoA hydrolase BC_2038 0.0239
4572 Acyl-CoA hydrolase BH0798 0.0239
4037 Hypothetical protein GPX1 0.0239
4297 Hypothetical protein SP_1951 0.0239
4521 Hypothetical protein BC_2969 0.0239
4540 Hypothetical protein TM_1070 0.0239
4555 Hypothetical protein MT1739 0.0239
4569 Hypothetical protein mshD 0.0239
4578 Hypothetical protein PA3270 0.0239
4747 Hypothetical protein PA3967 0.0239
5177 Hypothetical protein TM_0096 0.0239
5194 Hypothetical protein PA1204 0.0239
5240 Hypothetical protein Rv2991 0.0239
5370 Hypothetical protein TM_1158 0.0239
5710 Hypothetical protein Tb927.5.1360 0.0239
4577 4'-phosphopantetheinyl transferase sfp sfp 0.0239
2528 Fatty acid metabolism regulator protein fadR 0.0239
6740 Fatty acid metabolism regulator protein fadR 0.0239
1729 Solute carrier family 22 member 6 SLC22A6 0.0233
449 Ornithine decarboxylase ODC1 0.0233
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0233
1714 Mitogen-activated protein kinase 3 MAPK3 0.023
551 Carnitine O-acetyltransferase CRAT 0.0212
617 Muscarinic acetylcholine receptor M2 CHRM2 0.021
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0208
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0208
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0208
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.0208
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0208
4563 Acetyl transferase rimL 0.0208
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.0208
2396 Formyl-coenzyme A transferase frc 0.0208
3457 Formyl-coenzyme A transferase frc 0.0208
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.0208
3729 Citrate synthase gltA 0.0208
4575 Citrate synthase cit 0.0208
4580 Citrate synthase gltA 0.0208
3489 Acetyl-coenzyme A synthetase acs 0.0208
4118 Cytochrome P450 3A5 CYP3A5 0.0207
2429 Putrescine-binding periplasmic protein potF 0.0206
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0205
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0204
1176 Mitogen-activated protein kinase 1 MAPK1 0.0203
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0201
1629 Transcription factor AP-1 JUN 0.0196
6016 Cytochrome P450 2C19 CYP2C19 0.0196
3199 Phosphopantetheine adenylyltransferase coaD 0.0192
3543 Phosphopantetheine adenylyltransferase coaD 0.0192
3567 Phosphopantetheine adenylyltransferase coaD 0.0192
5289 Phosphopantetheine adenylyltransferase coaD 0.0192
2560 Galactoside O-acetyltransferase lacA 0.0192
2285 Streptogramin A acetyltransferase vatD 0.0192
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0192
2248 Malate synthase G glcB 0.0192
3190 Malate synthase G glcB 0.0192
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.0192
3178 Formate acetyltransferase 1 pflB 0.0192
4573 Histone acetyltransferase PCAF KAT2B 0.0192
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0183
4757 Cytochrome P450 2C9 CYP2C9 0.0183
6107 Cytochrome P450 3A7 CYP3A7 0.0183
4404 FcbC1 protein fcbC 0.0181
2371 Pantothenate kinase coaA 0.0181
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0181
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0173
1898 Cytochrome P450 1B1 CYP1B1 0.0169
492 Histamine H1 receptor HRH1 0.0168
2596 Acetyl-CoA acetyltransferase phbA 0.0158
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0156
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0156
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0156
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0156
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0152
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0149
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0147
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0144
150 Cationic amino acid transporter 3 SLC7A3 0.0144
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0144
58 Cationic amino acid transporter 4 SLC7A4 0.0144
303 Diamine acetyltransferase 2 SAT2 0.0141
1317 Spermine synthase SMS 0.0141
623 Spermine oxidase SMOX 0.0141
862 Multidrug resistance-associated protein 1 ABCC1 0.0138
587 Serum albumin ALB 0.0136
502 5-hydroxytryptamine 2A receptor HTR2A 0.0135
556 Alpha-1A adrenergic receptor ADRA1A 0.0131
3947 Xanthine dehydrogenase/oxidase XDH 0.0129
831 D(2) dopamine receptor DRD2 0.0128
6013 Cytochrome P450 2E1 CYP2E1 0.0128
123 Diamine acetyltransferase 1 SAT1 0.0127
6143 Solute carrier family 22 member 7 SLC22A7 0.0123
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0123
6030 Cytochrome P450 2B6 CYP2B6 0.0121
2472 Voltage-gated potassium channel kcsA 0.012
6366 Voltage-gated potassium channel kcsA 0.012
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0119
4924 Cytochrome P450 2C8 CYP2C8 0.0118
3923 Cholinesterase BCHE 0.0117
23 D(1A) dopamine receptor DRD1 0.0116
1024 Solute carrier family 22 member 11 SLC22A11 0.0114
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0113
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0113
221 Lysyl-tRNA synthetase KARS 0.0112
776 Bile salt export pump ABCB11 0.0112
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0111
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0111
378 Alpha-2C adrenergic receptor ADRA2C 0.0111
1181 Alpha-1-acid glycoprotein 1 ORM1 0.011
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0108
477 DNA topoisomerase 4 subunit A parC 0.0106
886 DNA topoisomerase 4 subunit A parC 0.0106
6226 DNA topoisomerase 4 subunit A parC 0.0106
404 DNA gyrase subunit A gyrA 0.0104
6224 DNA gyrase subunit A gyrA 0.0104
474 Acetylcholinesterase ACHE 0.0103
629 Alpha-2B adrenergic receptor ADRA2B 0.0099
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0095
766 Beta-2 adrenergic receptor ADRB2 0.0094
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0094
817 DNA topoisomerase 2-alpha TOP2A 0.0093
632 Alpha-1B adrenergic receptor ADRA1B 0.0092
5126 Arginase rocF 0.0091
672 Prostaglandin F2-alpha receptor PTGFR 0.009
318 Alpha-2A adrenergic receptor ADRA2A 0.0088
6151 Monocarboxylate transporter 10 SLC16A10 0.0087
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0085
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0085
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0084
341 5-hydroxytryptamine 3 receptor HTR3A 0.0083
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0083
320 5-hydroxytryptamine 1A receptor HTR1A 0.0082
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0082
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0082
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0082
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0082
193 Beta-1 adrenergic receptor ADRB1 0.0078
6106 Cytochrome P450 2C18 CYP2C18 0.0075
3939 Amine oxidase [flavin-containing] B MAOB 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
624 Guanidinoacetate N-methyltransferase GAMT 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
124 Histamine H2 receptor HRH2 0.0072
3941 Amine oxidase [flavin-containing] A MAOA 0.0071
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.007
824 Sodium-dependent serotonin transporter SLC6A4 0.007
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0066
976 Platelet glycoprotein IX GP9 0.0065
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0065
6014 Cytochrome P450 2A13 CYP2A13 0.0064
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
756 Sex hormone-binding globulin SHBG 0.0062
789 Alpha-1D adrenergic receptor ADRA1D 0.0062
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0061
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0061
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0059
6432 Transporter snf 0.0059
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0057
4773 Deoxycytidine kinase DCK 0.0057
499 Arginine decarboxylase ADC 0.0057
738 Monocarboxylate transporter 1 SLC16A1 0.0056
6148 Multidrug resistance-associated protein 7 ABCC10 0.0056
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0055
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0055
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0054
577 Argininosuccinate lyase ASL 0.0054
5109 Outer membrane protein p64k or PM-6 m-6 0.0054
5122 Mersacidin decarboxylase mrsD 0.0054
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0054
5115 FkbI fkbI 0.0054
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0054
5095 Putidaredoxin reductase camA 0.0054
3763 5,10-methylenetetrahydrofolate reductase metF 0.0054
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0054
5094 5,10-methylenetetrahydrofolate reductase metF 0.0054
5083 Cryptochrome DASH cry 0.0054
526 Thioredoxin reductase trxB 0.0054
3767 Thioredoxin reductase trxB 0.0054
5078 Amine oxidase, flavin-containing PSPTO1126 0.0054
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0054
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0054
5111 Phenylacetone monooxygenase pamO 0.0054
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0054
3133 UDP-galactopyranose mutase glf 0.0054
5099 UDP-galactopyranose mutase glf 0.0054
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0054
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0054
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0054
5081 L-aspartate oxidase nadB 0.0054
1410 Oxidoreductase HSD17B6 0.0054
4725 Oxidoreductase Not Available 0.0054
5124 Oxidoreductase Not Available 0.0054
834 Arginase-2, mitochondrial ARG2 0.0054
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0053
2300 Lysozyme E 0.0053
3633 Lysozyme R 0.0053
5597 Lysozyme 17 0.0053
5682 Ribonuclease pancreatic RNASE1 0.0052
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0052
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0052
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0052
769 High-affinity choline transporter 1 SLC5A7 0.0052
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0052
576 Choline O-acetyltransferase CHAT 0.0052
1686 Choline transporter-like protein 1 SLC44A1 0.0052
700 Choline dehydrogenase, mitochondrial CHDH 0.0052
3927 Choline transporter-like protein 3 SLC44A3 0.0052
3926 Choline transporter-like protein 2 SLC44A2 0.0052
861 Choline kinase alpha CHKA 0.0052
3922 Phospholipase D2 PLD2 0.0052
3925 Choline transporter-like protein 4 SLC44A4 0.0052
3924 Phospholipase D1 PLD1 0.0052
1074 Urokinase-type plasminogen activator PLAU 0.0052
6141 Sodium/bile acid cotransporter SLC10A1 0.0051
6171 Solute carrier family 28 member 3 SLC28A3 0.0049
4477 Dihydrolipoyl dehydrogenase lpdV 0.0049
5077 Dihydrolipoyl dehydrogenase Not Available 0.0049
5117 Dihydrolipoyl dehydrogenase lpd 0.0049
4486 Phenol 2-hydroxylase component B pheA2 0.0049
4439 Ferredoxin reductase bphA4 0.0049
740 Argininosuccinate synthase ASS1 0.0048
865 Argininosuccinate synthase ASS1 0.0048
2680 Argininosuccinate synthase argG 0.0048
3194 Argininosuccinate synthase argG 0.0048
6168 Solute carrier family 22 member 16 SLC22A16 0.0047
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0047
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0047
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0047
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0047
5073 Ferredoxin--NADP reductase petH 0.0047
5076 Ferredoxin--NADP reductase fpr 0.0047
5119 Ferredoxin--NADP reductase petH 0.0047
5121 Ferredoxin--NADP reductase fpr 0.0047
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0047
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0047
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0047
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0047
3594 Deoxyribodipyrimidine photo-lyase phr 0.0047
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0047
5080 Deoxyribodipyrimidine photo-lyase phr 0.0047
2268 Cholesterol oxidase choB 0.0047
2822 Cholesterol oxidase choA 0.0047
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0047
2526 NADPH-ferredoxin reductase fprA fprA 0.0047
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0047
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0047
2470 Pyruvate oxidase pox5 0.0047
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0047
731 HIV-1 protease HIV-1 protease 0.0047
5072 N,N-dimethylglycine oxidase dmg 0.0047
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0047
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0046
2164 Multidrug resistance-associated protein 4 ABCC4 0.0046
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0045
4440 NADH peroxidase npr 0.0045
3102 Flavohemoprotein hmp 0.0045
4969 Flavohemoprotein hmp 0.0045
2893 Glycine oxidase thiO 0.0043
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0043
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
1757 Myeloperoxidase MPO 0.0043
751 Potassium channel subfamily K member 6 KCNK6 0.0042
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0041
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0041
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0041
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0041
6070 Nischarin NISCH 0.0041
2823 Trypanothione reductase TPR 0.0041
2567 Thymidylate synthase thyX thyX 0.0041
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0041
5718 Cytochrome P450 2A6 CYP2A6 0.0041
1360 Sphingomyelin phosphodiesterase SMPD1 0.0041
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
450 Muscarinic acetylcholine receptor M4 CHRM4 0.004
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.004
327 Glutathione reductase gor 0.004
5110 Glutathione reductase GR2 0.004
694 Matrix protein 2 M 0.0039
2769 P-hydroxybenzoate hydroxylase pobA 0.0039
2809 P-hydroxybenzoate hydroxylase pobA 0.0039
172 Potassium channel subfamily K member 1 KCNK1 0.0039
126 D-lactate dehydrogenase dld 0.0039
3545 D-lactate dehydrogenase Not Available 0.0039
4510 D-lactate dehydrogenase ldhA 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0038
2380 Monomeric sarcosine oxidase soxA 0.0038
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0037
6645 D-amino-acid oxidase DAO 0.0036
1830 5'-nucleotidase NT5E 0.0035
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0035
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0034
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0034
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0034
136 Estrogen receptor ESR1 0.0034
125 DNA polymerase beta POLB 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
7 Nitric oxide synthase, inducible NOS2 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0033
291 Nitric-oxide synthase, endothelial NOS3 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0032
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0032
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0032
828 Phenylalanine-4-hydroxylase PAH 0.0032
3109 Phenylalanine-4-hydroxylase phhA 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0031
869 Estrogen receptor beta ESR2 0.0031
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0031
4604 Liver carboxylesterase 1 CES1 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.003
714 Glutathione reductase, mitochondrial GSR 0.003
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0029
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0029
3811 Cytochrome P450 19A1 CYP19A1 0.0029
713 Sodium-dependent dopamine transporter SLC6A3 0.0029
1341 Histamine H3 receptor HRH3 0.0028
76 Nitric-oxide synthase, brain NOS1 0.0028
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0027
6031 Cytochrome P450 3A43 CYP3A43 0.0027
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
164 Histamine H4 receptor HRH4 0.0026
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0026
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0025
4120 NADPH--cytochrome P450 reductase POR 0.0025
163 D(1B) dopamine receptor DRD5 0.0024
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
432 D(4) dopamine receptor DRD4 0.0023
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0022
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0022
6167 Organic solute transporter subunit beta OSTB 0.0022
6166 Organic solute transporter subunit alpha OSTA 0.0022
638 D(3) dopamine receptor DRD3 0.0022
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0022
146 Androgen receptor AR 0.0022
4203 Histamine N-methyltransferase HNMT 0.0021
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0021
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0021
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0021
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.002
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.002
465 Calmodulin CALM1 0.002
342 P protein [Includes: DNA-directed DNA polymerase P 0.002
612 P protein [Includes: DNA-directed DNA polymerase P 0.002
20 Prostaglandin G/H synthase 1 PTGS1 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.002
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0019
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0019
467 Delta-type opioid receptor OPRD1 0.0019
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
847 Mu-type opioid receptor OPRM1 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0017
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0017
702 UMP-CMP kinase CMPK1 0.0017
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0017
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0017
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0017
6136 Multidrug resistance-associated protein 5 ABCC5 0.0017
6165 Copper-transporting ATPase 1 ATP7A 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
1864 RET proto-oncogene RET 0.0015
277 Purine nucleoside phosphorylase PNP 0.0015
2870 Purine nucleoside phosphorylase punA 0.0015
2945 Purine nucleoside phosphorylase punA 0.0015
4659 Purine nucleoside phosphorylase TM_1596 0.0015
4825 Purine nucleoside phosphorylase TTHA1435 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
6146 High affinity copper uptake protein 1 SLC31A1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
908 Glutathione S-transferase theta-1 GSTT1 0.0014
5294 Nucleoside diphosphate kinase A NME1 0.0014
6218 Pannexin-1 PANX1 0.0014
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0013
436 5-hydroxytryptamine 2B receptor HTR2B 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
1618 High affinity nerve growth factor receptor NTRK1 0.0013
725 5-hydroxytryptamine 1D receptor HTR1D 0.0012
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0012
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0012
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0012
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0012
885 5-hydroxytryptamine 1B receptor HTR1B 0.0012
3587 Gastrotropin FABP6 0.0012
3810 Catechol O-methyltransferase COMT 0.0011
590 5-hydroxytryptamine 2C receptor HTR2C 0.0011
228 Beta platelet-derived growth factor receptor PDGFRB 0.0011
904 Glutathione S-transferase P GSTP1 0.0011
380 Cytochrome P450 17A1 CYP17A1 0.0011
6149 Solute carrier family 22 member 10 SLC22A10 0.0011
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0011
504 Mast/stem cell growth factor receptor KIT 0.001
737 Mineralocorticoid receptor NR3C2 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0009
614 Progesterone receptor PGR 0.0009
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0009
489 Monocarboxylate transporter 2 SLC16A7 0.0009
6085 Fatty acid-binding protein, intestinal FABP2 0.0009
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0009
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0008
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0008
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0007
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0007
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0007
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0007
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0007
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0007
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0007
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0007
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0007
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0007
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0007
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0007
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0007
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0006
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0006
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0006
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0006
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0006
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