DT-Web: DB00583

Identification
Name	L-Carnitine
Accession Number	DB00583 (APRD01070)
Type	small molecule
Description	Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias. [PubChem]
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)	Vitamin B Complex Vitamins (Vitamin B Complex) Nootropic Agents Metabolite Nutraceutical
Molecular Weight	161.1989
Groups	approved
Monoisotopic Weight	161.105193351
Pharmacology
Indication	For treatment of primary systemic carnitine deficiency, a genetic impairment of normal biosynthesis or utilization of levocarnitine from dietary sources, or for the treatment of secondary carnitine deficiency resulting from an inborn error of metabolism such as glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency. Used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias. Parenteral levocarnitine is indicated for the prevention and treatment of carnitine deficiency in patients with end-stage renal disease.
Mechanism of action	Levocarnitine can be synthesised within the body from the amino acids lysine or methionine. Vitamin C (ascorbic acid) is essential to the synthesis of carnitine. Levocarnitine is a carrier molecule in the transport of long chain fatty acids across the inner mitochondrial membrane. It also exports acyl groups from subcellular organelles and from cells to urine before they accumulate to toxic concentrations. Only the L isomer of carnitine (sometimes called vitamin BT) affects lipid metabolism. Levocarnitine is handled by several proteins in different pathways including carnitine transporters, carnitine translocases, carnitine acetyltransferases and carnitine palmitoyltransferases.
Absorption	Absolute bioavailability is 15% (tablets or solution). Time to maximum plasma concentration was found to be 3.3 hours.
Protein binding	None
Biotransformation	After oral administration L-carnitine which is unabsorbed is metabolized in the gastrointestinal tract by bacterial microflora. Major metabolites include trimethylamine N-oxide and [3H]-gamma-butyrobetaine.
Route of elimination	Following a single intravenous dose, 73.1 +/- 16% of the dose was excreted in the urine during the 0-24 hour interval. Post administration of oral carnitine supplements, in addition to a high carnitine diet, 58-65% of the administered radioactive dose was recovered from urine and feces in 5-11 days.
Toxicity	LD₅₀ > 8g/kg (mouse, oral). Adverse effects include hypertension, fever, tachycardia and seizures.
Affected organisms	Humans and other mammals
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

Organic cation/carnitine transporter 1
Name	Organic cation/carnitine transporter 1
Gene Name	SLC22A4
Pharmacological action	unknown
Actions	Not Available
References	Kristufek D, Rudorfer W, Pifl C, Huck S: Organic cation transporter mRNA and function in the rat superior cervical ganglion. J Physiol. 2002 Aug 15;543(Pt 1):117-34. - Pubmed Amat di San Filippo C, Wang Y, Longo N: Functional domains in the carnitine transporter OCTN2, defective in primary carnitine deficiency. J Biol Chem. 2003 Nov 28;278(48):47776-84. Epub 2003 Sep 23. - Pubmed Lamhonwah AM, Ackerley C, Onizuka R, Tilups A, Lamhonwah D, Chung C, Tao KS, Tellier R, Tein I: Epitope shared by functional variant of organic cation/carnitine transporter, OCTN1, Campylobacter jejuni and Mycobacterium paratuberculosis may underlie susceptibility to Crohn's disease at 5q31. Biochem Biophys Res Commun. 2005 Dec 2;337(4):1165-75. Epub 2005 Oct 6. - Pubmed Lash LH, Putt DA, Cai H: Membrane transport function in primary cultures of human proximal tubular cells. Toxicology. 2006 Dec 7;228(2-3):200-18. Epub 2006 Sep 1. - Pubmed
DTHybrid score	0.393
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Pharmacological action	unknown
Actions	Not Available
References	Lahjouji K, Elimrani I, Wu J, Mitchell GA, Qureshi IA: A heterozygote phenotype is present in the jvs +/- mutant mouse livers. Mol Genet Metab. 2002 May;76(1):76-80. - Pubmed Kristufek D, Rudorfer W, Pifl C, Huck S: Organic cation transporter mRNA and function in the rat superior cervical ganglion. J Physiol. 2002 Aug 15;543(Pt 1):117-34. - Pubmed Ohashi R, Tamai I, Inano A, Katsura M, Sai Y, Nezu J, Tsuji A: Studies on functional sites of organic cation/carnitine transporter OCTN2 (SLC22A5) using a Ser467Cys mutant protein. J Pharmacol Exp Ther. 2002 Sep;302(3):1286-94. - Pubmed Hou JW: Primary systemic carnitine deficiency presenting as recurrent Reye-like syndrome and dilated cardiomyopathy. Chang Gung Med J. 2002 Dec;25(12):832-7. - Pubmed Friedrich A, Prasad PD, Freyer D, Ganapathy V, Brust P: Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood-brain barrier. Brain Res. 2003 Apr 4;968(1):69-79. - Pubmed
DTHybrid score	0.4427
Carnitine O-acetyltransferase
Name	Carnitine O-acetyltransferase
Gene Name	CRAT
Pharmacological action	unknown
Actions	Not Available
References	Jogl G, Tong L: Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport. Cell. 2003 Jan 10;112(1):113-22. - Pubmed Wu D, Govindasamy L, Lian W, Gu Y, Kukar T, Agbandje-McKenna M, McKenna R: Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer. J Biol Chem. 2003 Apr 11;278(15):13159-65. Epub 2003 Jan 31. - Pubmed Vikramadithyan RK, Hiriyan J, Suresh J, Gershome C, Babu RK, Misra P, Rajagopalan R, Chakrabarti R: DRF 2655: a unique molecule that reduces body weight and ameliorates metabolic abnormalities. Obes Res. 2003 Feb;11(2):292-303. - Pubmed Govindasamy L, Kukar T, Lian W, Pedersen B, Gu Y, Agbandje-McKenna M, Jin S, McKenna R, Wu D: Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. J Struct Biol. 2004 Jun;146(3):416-24. - Pubmed Cordente AG, Lopez-Vinas E, Vazquez MI, Swiegers JH, Pretorius IS, Gomez-Puertas P, Hegardt FG, Asins G, Serra D: Redesign of carnitine acetyltransferase specificity by protein engineering. J Biol Chem. 2004 Aug 6;279(32):33899-908. Epub 2004 May 21. - Pubmed
DTHybrid score	0.9917
Mitochondrial carnitine/acylcarnitine carrier protein CACL
Name	Mitochondrial carnitine/acylcarnitine carrier protein CACL
Gene Name	SLC25A29
Pharmacological action	unknown
Actions	Not Available
References	Sekoguchi E, Sato N, Yasui A, Fukada S, Nimura Y, Aburatani H, Ikeda K, Matsuura A: A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting. J Biol Chem. 2003 Oct 3;278(40):38796-802. Epub 2003 Jul 25. - Pubmed
DTHybrid score	0.5568
Mitochondrial carnitine/acylcarnitine carrier protein
Name	Mitochondrial carnitine/acylcarnitine carrier protein
Gene Name	SLC25A20
Pharmacological action	unknown
Actions	Not Available
References	Sekoguchi E, Sato N, Yasui A, Fukada S, Nimura Y, Aburatani H, Ikeda K, Matsuura A: A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting. J Biol Chem. 2003 Oct 3;278(40):38796-802. Epub 2003 Jul 25. - Pubmed Peluso G, Petillo O, Margarucci S, Grippo P, Melone MA, Tuccillo F, Calvani M: Differential carnitine/acylcarnitine translocase expression defines distinct metabolic signatures in skeletal muscle cells. J Cell Physiol. 2005 May;203(2):439-46. - Pubmed Tonazzi A, Giangregorio N, Indiveri C, Palmieri F: Identification by site-directed mutagenesis and chemical modification of three vicinal cysteine residues in rat mitochondrial carnitine/acylcarnitine transporter. J Biol Chem. 2005 May 20;280(20):19607-12. Epub 2005 Mar 9. - Pubmed
DTHybrid score	0.5569
Peroxisomal carnitine O-octanoyltransferase
Name	Peroxisomal carnitine O-octanoyltransferase
Gene Name	CROT
Pharmacological action	unknown
Actions	Not Available
References	Cordente AG, Lopez-Vinas E, Vazquez MI, Swiegers JH, Pretorius IS, Gomez-Puertas P, Hegardt FG, Asins G, Serra D: Redesign of carnitine acetyltransferase specificity by protein engineering. J Biol Chem. 2004 Aug 6;279(32):33899-908. Epub 2004 May 21. - Pubmed Cordente AG, Lopez-Vinas E, Vazquez MI, Gomez-Puertas P, Asins G, Serra D, Hegardt FG: Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase. Biochemistry. 2006 May 16;45(19):6133-41. - Pubmed
DTHybrid score	1.6429
Carnitine O-palmitoyltransferase 2, mitochondrial
Name	Carnitine O-palmitoyltransferase 2, mitochondrial
Gene Name	CPT2
Pharmacological action	unknown
Actions	Not Available
References	Barrero MJ, Camarero N, Marrero PF, Haro D: Control of human carnitine palmitoyltransferase II gene transcription by peroxisome proliferator-activated receptor through a partially conserved peroxisome proliferator-responsive element. Biochem J. 2003 Feb 1;369(Pt 3):721-9. - Pubmed Kong JY, Rabkin SW: Lovastatin does not accentuate but is rather additive to palmitate-induced apoptosis in cardiomyocytes. Prostaglandins Leukot Essent Fatty Acids. 2002 Nov;67(5):293-302. - Pubmed Rasmussen BB, Holmback UC, Volpi E, Morio-Liondore B, Paddon-Jones D, Wolfe RR: Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J Clin Invest. 2002 Dec;110(11):1687-93. - Pubmed Price NT, Jackson VN, van der Leij FR, Cameron JM, Travers MT, Bartelds B, Huijkman NC, Zammit VA: Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme. Biochem J. 2003 Jun 15;372(Pt 3):871-9. - Pubmed Lehtihet M, Welsh N, Berggren PO, Cook GA, Sjoholm A: Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis. Am J Physiol Endocrinol Metab. 2003 Aug;285(2):E438-46. Epub 2003 Apr 8. - Pubmed
DTHybrid score	0.7221
Carnitine O-palmitoyltransferase I, liver isoform
Name	Carnitine O-palmitoyltransferase I, liver isoform
Gene Name	CPT1A
Pharmacological action	unknown
Actions	activator
References	Xu ZR, Wang MQ, Mao HX, Zhan XA, Hu CH: Effects of L-carnitine on growth performance, carcass composition, and metabolism of lipids in male broilers. Poult Sci. 2003 Mar;82(3):408-13. - Pubmed Morillas M, Lopez-VVinas E, Valencia A, Serra D, Gomez-Puertas P, Hegardt FG, Asins G: Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal. Biochem J. 2004 May 1;379(Pt 3):777-84. - Pubmed Tripodi G, Modica R, Stella A, Bigatti G, Bianchi G, Stella P: Haplotype analysis of carnitine transporters and left ventricular mass in human essential hypertension. J Ren Nutr. 2005 Jan;15(1):2-7. - Pubmed Waldner R, Laschan C, Lohninger A, Gessner M, Tuchler H, Huemer M, Spiegel W, Karlic H: Effects of doxorubicin-containing chemotherapy and a combination with L-carnitine on oxidative metabolism in patients with non-Hodgkin lymphoma. J Cancer Res Clin Oncol. 2006 Feb;132(2):121-8. Epub 2005 Nov 8. - Pubmed Shin ES, Cho SY, Lee EH, Lee SJ, Chang IS, Lee TR: Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine. Eur J Nutr. 2006 Mar;45(3):159-64. Epub 2005 Dec 20. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.7221
Xanthine dehydrogenase/oxidase
Name	Xanthine dehydrogenase/oxidase
Gene Name	XDH
Pharmacological action	unknown
Actions	Not Available
References	Di Giacomo C, Latteri F, Fichera C, Sorrenti V, Campisi A, Castorina C, Russo A, Pinturo R, Vanella A: Effect of acetyl-L-carnitine on lipid peroxidation and xanthine oxidase activity in rat skeletal muscle. Neurochem Res. 1993 Nov;18(11):1157-62. - Pubmed
DTHybrid score	0.6318
Liver carboxylesterase 1
Name	Liver carboxylesterase 1
Gene Name	CES1
Pharmacological action	unknown
Actions	Not Available
References	Bell FP: Carnitine ester hydrolysis in arteries from normal and cholesterol-fed rabbits and the effects of carnitine esters on arterial microsomal ACAT. Comp Biochem Physiol B. 1984;79(2):125-8. - Pubmed
DTHybrid score	0.7306
Myeloperoxidase
Name	Myeloperoxidase
Gene Name	MPO
Pharmacological action	unknown
Actions	Not Available
References	Derin N, Agac A, Bayram Z, Asar M, Izgut-Uysal VN: Effects of L-carnitine on neutrophil-mediated ischemia-reperfusion injury in rat stomach. Cell Biochem Funct. 2006 Sep-Oct;24(5):437-42. - Pubmed
DTHybrid score	0.5256

Organic cation/carnitine transporter 1
Name	Organic cation/carnitine transporter 1
Gene Name	SLC22A4
Actions	substrate,inhibitor
References	Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed Tamai I, Ohashi R, Nezu JI, Sai Y, Kobayashi D, Oku A, Shimane M, Tsuji A: Molecular and functional characterization of organic cation/carnitine transporter family in mice. J Biol Chem. 2000 Dec 22;275(51):40064-72. - Pubmed
DTHybrid score	0.393
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A: Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin. J Pharm Pharmacol. 2003 Jul;55(7):1013-20. - Pubmed
DTHybrid score	0.3644
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	substrate
References	Tamai I, China K, Sai Y, Kobayashi D, Nezu J, Kawahara E, Tsuji A: Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochim Biophys Acta. 2001 Jun 6;1512(2):273-84. - Pubmed Friedrich A, Prasad PD, Freyer D, Ganapathy V, Brust P: Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood-brain barrier. Brain Res. 2003 Apr 4;968(1):69-79. - Pubmed Elimrani I, Lahjouji K, Seidman E, Roy MJ, Mitchell GA, Qureshi I: Expression and localization of organic cation/carnitine transporter OCTN2 in Caco-2 cells. Am J Physiol Gastrointest Liver Physiol. 2003 May;284(5):G863-71. Epub 2003 Jan 10. - Pubmed Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed Tamai I, Ohashi R, Nezu JI, Sai Y, Kobayashi D, Oku A, Shimane M, Tsuji A: Molecular and functional characterization of organic cation/carnitine transporter family in mice. J Biol Chem. 2000 Dec 22;275(51):40064-72. - Pubmed Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score	0.4427
Solute carrier family 22 member 16
Name	Solute carrier family 22 member 16
Gene Name	SLC22A16
Actions	substrate
References	Enomoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N, Goto A, Sakamoto A, Niwa T, Kanai Y, Anders MW, Endou H: Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. J Biol Chem. 2002 Sep 27;277(39):36262-71. Epub 2002 Jun 27. - Pubmed
DTHybrid score	0.4406
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate
References	Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. - Pubmed
DTHybrid score	0.4015

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.1949
4119	Cytochrome P450 2D6	CYP2D6	0.1707
6030	Cytochrome P450 2B6	CYP2B6	0.1419
1729	Solute carrier family 22 member 6	SLC22A6	0.1368
1588	Multidrug resistance protein 1	ABCB1	0.1192
6145	Solute carrier family 22 member 1	SLC22A1	0.1036
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0963
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0915
4200	Cytochrome P450 1A2	CYP1A2	0.0899
1024	Solute carrier family 22 member 11	SLC22A11	0.0872
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0837
6144	Solute carrier family 22 member 2	SLC22A2	0.0823
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0797
4757	Cytochrome P450 2C9	CYP2C9	0.0779
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0733
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0715
6143	Solute carrier family 22 member 7	SLC22A7	0.0706
290	Prostaglandin G/H synthase 2	PTGS2	0.0669
4924	Cytochrome P450 2C8	CYP2C8	0.0633
6147	Solute carrier family 22 member 3	SLC22A3	0.0619
6020	Aldehyde oxidase	AOX1	0.0614
862	Multidrug resistance-associated protein 1	ABCC1	0.0581
587	Serum albumin	ALB	0.0566
6016	Cytochrome P450 2C19	CYP2C19	0.0564
4118	Cytochrome P450 3A5	CYP3A5	0.0518
20	Prostaglandin G/H synthase 1	PTGS1	0.0516
1898	Cytochrome P450 1B1	CYP1B1	0.0509
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0498
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0498
2164	Multidrug resistance-associated protein 4	ABCC4	0.0454
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.042
6024	Cytochrome P450 1A1	CYP1A1	0.0418
776	Bile salt export pump	ABCB11	0.0413
817	DNA topoisomerase 2-alpha	TOP2A	0.0399
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0383
6013	Cytochrome P450 2E1	CYP2E1	0.0381
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.0374
6137	Multidrug resistance-associated protein 6	ABCC6	0.0353
6606	Platelet-activating factor acetylhydrolase IB subunit gamma	PAFAH1B3	0.0348
4175	Platelet-activating factor acetylhydrolase	PLA2G7	0.0348
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0347
6107	Cytochrome P450 3A7	CYP3A7	0.0344
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0333
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0332
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0322
1736	Somatostatin	SST	0.0311
4186	Neuropeptide Y receptor type 2	NPY2R	0.0311
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0305
54	Prothrombin	F2	0.0297
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0297
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0296
275	Arachidonate 5-lipoxygenase	ALOX5	0.029
6148	Multidrug resistance-associated protein 7	ABCC10	0.029
723	Cytosolic phospholipase A2	PLA2G4A	0.0284
477	DNA topoisomerase 4 subunit A	parC	0.0283
886	DNA topoisomerase 4 subunit A	parC	0.0283
6226	DNA topoisomerase 4 subunit A	parC	0.0283
633	Penicillin-binding proteins 1A/1B	pbpA	0.0281
449	Ornithine decarboxylase	ODC1	0.028
404	DNA gyrase subunit A	gyrA	0.0279
6224	DNA gyrase subunit A	gyrA	0.0279
563	Thyroid peroxidase	TPO	0.0277
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0273
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0273
896	Glutathione S-transferase Mu 1	GSTM1	0.0268
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0264
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0263
309	Antithrombin-III	SERPINC1	0.0261
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.026
153	Dopamine beta-hydroxylase	DBH	0.0256
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0255
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0255
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0255
159	Penicillin-binding protein 2B	penA	0.0255
6121	Penicillin-binding protein 2B	penA	0.0255
738	Monocarboxylate transporter 1	SLC16A1	0.0242
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0239
6136	Multidrug resistance-associated protein 5	ABCC5	0.0236
6141	Sodium/bile acid cotransporter	SLC10A1	0.0234
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.023
3923	Cholinesterase	BCHE	0.0228
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0223
1405	Thiopurine S-methyltransferase	TPMT	0.0219
492	Histamine H1 receptor	HRH1	0.0217
6165	Copper-transporting ATPase 1	ATP7A	0.0215
6163	Copper-transporting ATPase 2	ATP7B	0.0215
503	Somatostatin receptor type 1	SSTR1	0.0214
3866	Serum amyloid A protein	SAA1	0.0209
1932	Apolipoprotein E	APOE	0.0208
1200	AMBP protein	AMBP	0.0208
4120	NADPH--cytochrome P450 reductase	POR	0.0207
2429	Putrescine-binding periplasmic protein	potF	0.0206
303	Diamine acetyltransferase 2	SAT2	0.0205
1317	Spermine synthase	SMS	0.0205
623	Spermine oxidase	SMOX	0.0205
6146	High affinity copper uptake protein 1	SLC31A1	0.0205
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0201
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0201
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0201
3872	Somatostatin receptor type 5	SSTR5	0.02
6008	Somatostatin receptor type 2	SSTR2	0.02
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0198
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0197
908	Glutathione S-transferase theta-1	GSTT1	0.0195
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0195
239	Coagulation factor X	F10	0.0191
3811	Cytochrome P450 19A1	CYP19A1	0.019
51	Muscarinic acetylcholine receptor M3	CHRM3	0.019
856	Vitamin D3 receptor	VDR	0.0189
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0189
123	Diamine acetyltransferase 1	SAT1	0.0186
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0186
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0185
3941	Amine oxidase [flavin-containing] A	MAOA	0.0182
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0181
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.018
5251	Carbonyl reductase [NADPH] 1	CBR1	0.018
7	Nitric oxide synthase, inducible	NOS2	0.018
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0179
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0176
291	Nitric-oxide synthase, endothelial	NOS3	0.0175
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0174
150	Cationic amino acid transporter 3	SLC7A3	0.0173
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.0173
58	Cationic amino acid transporter 4	SLC7A4	0.0173
1141	Sialidase-1	NEU1	0.0169
64	Neuraminidase	NA	0.0169
641	Neuraminidase	NA	0.0169
2676	Neuraminidase	NA	0.0169
3026	Neuraminidase	NA	0.0169
3519	Neuraminidase	NA	0.0169
6007	Neuraminidase	NA	0.0169
5718	Cytochrome P450 2A6	CYP2A6	0.0168
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0166
63	Malate dehydrogenase	mdh	0.0165
2329	Malate dehydrogenase	mdh	0.0165
3445	Malate dehydrogenase	mdh	0.0165
4420	Malate dehydrogenase	mdh	0.0165
4438	Malate dehydrogenase	mdh	0.0165
2472	Voltage-gated potassium channel	kcsA	0.0165
6366	Voltage-gated potassium channel	kcsA	0.0165
3587	Gastrotropin	FABP6	0.0163
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0159
645	Penicillin-binding protein 1A	mrcA	0.0157
5805	Penicillin-binding protein 1A	ponA	0.0157
6185	Penicillin-binding protein 1A	mrcA	0.0157
6799	Penicillin-binding protein 1A	pbpA	0.0157
76	Nitric-oxide synthase, brain	NOS1	0.0156
327	Glutathione reductase	gor	0.0156
5110	Glutathione reductase	GR2	0.0156
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0155
904	Glutathione S-transferase P	GSTP1	0.0155
6151	Monocarboxylate transporter 10	SLC16A10	0.0153
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0152
3823	Cytokine receptor common gamma chain	IL2RG	0.0151
624	Guanidinoacetate N-methyltransferase	GAMT	0.015
244	Angiotensin-converting enzyme	ACE	0.015
6106	Cytochrome P450 2C18	CYP2C18	0.015
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.015
4567	Putative acyl-CoA thioester hydrolase HI0827	HI_0827	0.015
4564	YvbK protein	yvbK	0.015
4566	Acyl-CoA hydrolase	BC_2038	0.015
4572	Acyl-CoA hydrolase	BH0798	0.015
4576	Aac(6')-Ii protein	aac(6')-Ii	0.015
4577	4'-phosphopantetheinyl transferase sfp	sfp	0.015
2528	Fatty acid metabolism regulator protein	fadR	0.015
6740	Fatty acid metabolism regulator protein	fadR	0.015
4579	Serine acetyltransferase	cysE	0.015
6807	Serine acetyltransferase	cysE	0.015
4037	Hypothetical protein	GPX1	0.015
4297	Hypothetical protein	SP_1951	0.015
4521	Hypothetical protein	BC_2969	0.015
4540	Hypothetical protein	TM_1070	0.015
4555	Hypothetical protein	MT1739	0.015
4569	Hypothetical protein	mshD	0.015
4578	Hypothetical protein	PA3270	0.015
4747	Hypothetical protein	PA3967	0.015
5177	Hypothetical protein	TM_0096	0.015
5194	Hypothetical protein	PA1204	0.015
5240	Hypothetical protein	Rv2991	0.015
5370	Hypothetical protein	TM_1158	0.015
5710	Hypothetical protein	Tb927.5.1360	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0149
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0149
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0148
5482	Sialidase-2	NEU2	0.0141
713	Sodium-dependent dopamine transporter	SLC6A3	0.0139
124	Histamine H2 receptor	HRH2	0.0138
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0137
3939	Amine oxidase [flavin-containing] B	MAOB	0.0137
2178	Metabotropic glutamate receptor 5	GRM5	0.0136
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0136
3729	Citrate synthase	gltA	0.0134
4575	Citrate synthase	cit	0.0134
4580	Citrate synthase	gltA	0.0134
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0133
2409	Acetyl-CoA acetyltransferase, cytosolic	ACAT2	0.0133
4563	Acetyl transferase	rimL	0.0132
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0132
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0132
3125	Protease synthase and sporulation negative regulatory protein PAI 1	paiA	0.0132
724	Interleukin-2 receptor alpha chain	IL2RA	0.0131
717	Interleukin-2 receptor subunit beta	IL2RB	0.0131
3024	Crotonobetainyl-CoA:carnitine CoA-transferase	caiB	0.0131
4574	PROBABLE NAPHTHOATE SYNTHASE MENB	menB	0.013
2396	Formyl-coenzyme A transferase	frc	0.013
3457	Formyl-coenzyme A transferase	frc	0.013
4565	Aminoglycoside 6'-N-acetyltransferase	aac(6')-Iy	0.013
3489	Acetyl-coenzyme A synthetase	acs	0.013
758	Thyroid hormone receptor alpha	THRA	0.0129
122	P2Y purinoceptor 12	P2RY12	0.0126
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0126
5126	Arginase	rocF	0.0125
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0124
2248	Malate synthase G	glcB	0.0123
3190	Malate synthase G	glcB	0.0123
3178	Formate acetyltransferase 1	pflB	0.0122
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0121
2377	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex	Not Available	0.012
3199	Phosphopantetheine adenylyltransferase	coaD	0.012
3543	Phosphopantetheine adenylyltransferase	coaD	0.012
3567	Phosphopantetheine adenylyltransferase	coaD	0.012
5289	Phosphopantetheine adenylyltransferase	coaD	0.012
2285	Streptogramin A acetyltransferase	vatD	0.012
2560	Galactoside O-acetyltransferase	lacA	0.012
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.012
4573	Histone acetyltransferase PCAF	KAT2B	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0119
2371	Pantothenate kinase	coaA	0.0118
70	Type-1 angiotensin II receptor	AGTR1	0.0117
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0116
1	Peptidoglycan synthetase ftsI	ftsI	0.0115
4155	Peptidoglycan synthetase ftsI	ftsI	0.0115
2016	Dipeptidase 1	DPEP1	0.0115
346	Thyroid hormone receptor beta-1	THRB	0.0115
4404	FcbC1 protein	fcbC	0.0114
543	Penicillin-binding protein 1B	mrcB	0.0113
6186	Penicillin-binding protein 1B	ponB	0.0113
6822	Penicillin-binding protein 1b	pbp1b	0.0113
6844	Penicillin-binding protein 1b	pbp1b	0.0113
556	Alpha-1A adrenergic receptor	ADRA1A	0.0113
221	Lysyl-tRNA synthetase	KARS	0.0112
2376	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	dapD	0.0111
6167	Organic solute transporter subunit beta	OSTB	0.011
6166	Organic solute transporter subunit alpha	OSTA	0.011
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.011
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0109
1656	CYP2B protein	CYP2B	0.0108
3611	Cytidine deaminase	cdd	0.0106
3707	Cytidine deaminase	cdd	0.0106
4211	Cytidine deaminase	CDA	0.0106
332	Beta-lactamase	blaZ	0.0105
2478	Beta-lactamase	ampC	0.0105
2613	Beta-lactamase	ampC	0.0105
2635	Beta-lactamase	ampC	0.0105
2700	Beta-lactamase	penP	0.0105
5445	Beta-lactamase	blaB	0.0105
6019	Beta-lactamase	SHV-7	0.0105
6701	Beta-lactamase	cphA	0.0105
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0103
22	30S ribosomal protein S4	rpsD	0.0101
6714	30S ribosomal protein S4	rpsD	0.0101
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0101
3639	Thymidine phosphorylase	deoA	0.0101
3936	Thymidine phosphorylase	TYMP	0.0101
24	Thymidylate synthase	TMP1	0.0101
359	Thymidylate synthase	TYMS	0.0101
2626	Thymidylate synthase	thyA	0.0101
2729	Thymidylate synthase	thyA	0.0101
5352	Thymidylate synthase	THYA	0.0101
615	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0101
3138	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0101
4568	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0101
6370	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0101
3932	Glutathione S-transferase A2	GSTA2	0.01
2596	Acetyl-CoA acetyltransferase	phbA	0.01
4031	Glutathione S-transferase A1	GSTA1	0.01
338	DNA polymerase	UL30	0.01
379	DNA polymerase	UL54	0.01
697	DNA polymerase	ORF28	0.01
2482	DNA polymerase	43	0.01
4104	DNA polymerase	BALF5	0.01
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
619	Low-affinity cationic amino acid transporter 2	SLC7A2	0.0098
594	Thyroxine-binding globulin	SERPINA7	0.0097
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0097
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0095
140	30S ribosomal protein S9	rpsI	0.0095
6719	30S ribosomal protein S9	rpsI	0.0095
6725	30S ribosomal protein S9	rpsI	0.0095
629	Alpha-2B adrenergic receptor	ADRA2B	0.0095
232	Corticosteroid-binding globulin	SERPINA6	0.0095
4388	Aminoglycoside 2'-N-acetyltransferase	aac	0.0095
6171	Solute carrier family 28 member 3	SLC28A3	0.0095
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0092
6859	Protein S100-A4	S100A4	0.0091
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0091
465	Calmodulin	CALM1	0.0089
499	Arginine decarboxylase	ADC	0.0089
6010	Thiamine transporter 1	SLC19A2	0.0089
136	Estrogen receptor	ESR1	0.0088
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0088
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0087
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0086
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0085
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0085
577	Argininosuccinate lyase	ASL	0.0085
318	Alpha-2A adrenergic receptor	ADRA2A	0.0085
834	Arginase-2, mitochondrial	ARG2	0.0084
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0084
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0084
871	Glucocorticoid receptor	NR3C1	0.0081
5880	Thrombopoietin receptor	MPL	0.0081
175	Thiamin pyrophosphokinase 1	TPK1	0.008
468	Cytochrome P450 4A11	CYP4A11	0.008
378	Alpha-2C adrenergic receptor	ADRA2C	0.008
474	Acetylcholinesterase	ACHE	0.0079
3830	Calreticulin	CALR	0.0079
6036	Eosinophil peroxidase	EPX	0.0078
740	Argininosuccinate synthase	ASS1	0.0076
865	Argininosuccinate synthase	ASS1	0.0076
2680	Argininosuccinate synthase	argG	0.0076
3194	Argininosuccinate synthase	argG	0.0076
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0075
6034	Hydroxyindole O-methyltransferase	ASMT	0.0075
6035	Nuclear receptor ROR-beta	RORB	0.0075
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0074
193	Beta-1 adrenergic receptor	ADRB1	0.0073
751	Potassium channel subfamily K member 6	KCNK6	0.0073
1636	Trace amine-associated receptor 1	TAAR1	0.0073
2300	Lysozyme	E	0.0073
3633	Lysozyme	R	0.0073
5597	Lysozyme	17	0.0073
5682	Ribonuclease pancreatic	RNASE1	0.0072
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0072
766	Beta-2 adrenergic receptor	ADRB2	0.0072
6149	Solute carrier family 22 member 10	SLC22A10	0.0071
5414	Fiber protein	L5	0.0071
5418	Fiber protein	L5	0.0071
1756	E-selectin	SELE	0.0071
438	Taste receptor type 1 member 2	TAS1R2	0.0071
824	Sodium-dependent serotonin transporter	SLC6A4	0.007
976	Platelet glycoprotein IX	GP9	0.007
731	HIV-1 protease	HIV-1 protease	0.0069
756	Sex hormone-binding globulin	SHBG	0.0069
172	Potassium channel subfamily K member 1	KCNK1	0.0067
373	Transthyretin	TTR	0.0067
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0067
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0067
5626	Nucleoside diphosphate kinase B	NME2	0.0067
558	Solute carrier family 12 member 1	SLC12A1	0.0066
6014	Cytochrome P450 2A13	CYP2A13	0.0066
3686	Acyl-CoA thioesterase I precursor	tesA	0.0065
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0065
3601	Dihydropteroate synthase 1	folP1	0.0065
3807	Dihydropteroate synthase 1	folP1	0.0065
3808	Dihydropteroate synthase 2	folP2	0.0065
765	Indoleamine 2,3-dioxygenase	IDO1	0.0065
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0064
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0064
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0064
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
3629	Endo-N-acetylneuraminidase	Not Available	0.0062
5416	Coat protein VP1	Not Available	0.0061
1130	Lithostathine 1 alpha	REG1A	0.0061
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0061
362	Melatonin receptor type 1B	MTNR1B	0.0061
571	Melatonin receptor type 1A	MTNR1A	0.0061
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.006
183	Vascular endothelial growth factor A	VEGFA	0.006
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.006
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0059
131	Synaptic vesicular amine transporter	SLC18A2	0.0059
6067	Penicillin binding protein 2a	mecA	0.0058
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0058
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0058
1353	DNA topoisomerase 1	TOP1	0.0058
3552	DNA topoisomerase 1	topA	0.0058
887	DNA gyrase subunit B	gyrB	0.0057
4150	DNA gyrase subunit B	gyrB	0.0057
6225	DNA gyrase subunit B	gyrB	0.0057
788	Creatine kinase M-type	CKM	0.0057
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0057
2324	Botulinum neurotoxin type B	botB	0.0057
3547	Enterotoxin type B	entB	0.0057
2058	P-selectin	SELP	0.0056
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0056
2391	Ferrochelatase	hemH	0.0056
6502	Ferrochelatase	DKFZp686P18130	0.0056
1591	Ferrochelatase, mitochondrial	FECH	0.0056
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0055
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0055
769	High-affinity choline transporter 1	SLC5A7	0.0055
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0055
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0055
576	Choline O-acetyltransferase	CHAT	0.0055
700	Choline dehydrogenase, mitochondrial	CHDH	0.0055
861	Choline kinase alpha	CHKA	0.0055
3927	Choline transporter-like protein 3	SLC44A3	0.0055
1686	Choline transporter-like protein 1	SLC44A1	0.0055
3922	Phospholipase D2	PLD2	0.0055
3926	Choline transporter-like protein 2	SLC44A2	0.0055
3925	Choline transporter-like protein 4	SLC44A4	0.0055
3924	Phospholipase D1	PLD1	0.0055
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0055
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0055
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0055
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0055
26	Vascular endothelial growth factor receptor 3	FLT4	0.0055
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0055
5294	Nucleoside diphosphate kinase A	NME1	0.0055
5353	Glutamate decarboxylase alpha	gadA	0.0054
32	Vascular endothelial growth factor receptor 1	FLT1	0.0053
6432	Transporter	snf	0.0052
860	Nicotinamide N-methyltransferase	NNMT	0.0051
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0051
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0051
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0051
699	Nicotinic acid receptor 1	GPR109A	0.0051
928	Nicotinic acid receptor 2	GPR109B	0.0051
1374	Natriuretic peptides B	NPPB	0.0051
1827	Gap junction alpha-1 protein	GJA1	0.0051
1908	Vascular cell adhesion protein 1	VCAM1	0.0051
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0051
400	Coagulation factor IX	F9	0.005
5461	Coagulation factor IX	F9	0.005
199	Monocarboxylate transporter 8	SLC16A2	0.005
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.005
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.005
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0049
2570	Tetanus toxin	tetX	0.0049
3809	Estrogen-related receptor gamma	ESRRG	0.0049
831	D(2) dopamine receptor	DRD2	0.0049
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0049
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0049
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0049
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0049
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0049
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0049
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0049
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0049
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0049
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0049
6559	Cytochrome c oxidase subunit 2	ctaC	0.0049
6669	Cytochrome c oxidase subunit 2	ctaC	0.0049
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0048
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0048
6558	Cytochrome c oxidase subunit 1	ctaD	0.0048
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0048
380	Cytochrome P450 17A1	CYP17A1	0.0046
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0046
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0046
604	Vitamin K-dependent protein Z	PROZ	0.0046
789	Alpha-1D adrenergic receptor	ADRA1D	0.0046
952	Dipeptidyl peptidase 4	DPP4	0.0046
6102	Arylamine N-acetyltransferase 2	NAT2	0.0045
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0045
6500	Phospholipase A2	PLA2G1B	0.0045
2540	Choloylglycine hydrolase	cbh	0.0044
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0044
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0043
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0043
407	Vascular endothelial growth factor receptor 2	KDR	0.0043
146	Androgen receptor	AR	0.0043
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
6042	Prostaglandin reductase 2	PTGR2	0.0042
422	Vitamin K-dependent protein C	PROC	0.0042
1245	Vitamin K-dependent protein S	PROS1	0.0042
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0042
6501	Fatty acid-binding protein, liver	FABP1	0.0042
2723	Cholera enterotoxin subunit B	ctxB	0.0042
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0041
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.004
33	Cystine/glutamate transporter	SLC7A11	0.004
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0039
1867	Major prion protein	PRNP	0.0039
4192	DNA topoisomerase 2-beta	TOP2B	0.0039
828	Phenylalanine-4-hydroxylase	PAH	0.0039
3109	Phenylalanine-4-hydroxylase	phhA	0.0039
737	Mineralocorticoid receptor	NR3C2	0.0039
3685	Catabolite gene activator	crp	0.0038
6043	Putative G-protein coupled receptor 44	GPR44	0.0038
4655	Adenylate cyclase	cyaC	0.0038
4759	Adenylate cyclase	cyaB2	0.0038
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0038
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0037
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0037
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0037
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0037
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0037
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0037
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0037
6031	Cytochrome P450 3A43	CYP3A43	0.0036
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0036
130	Prostacyclin synthase	PTGIS	0.0036
2539	Tubulin alpha-1 chain	TUBA4A	0.0035
1074	Urokinase-type plasminogen activator	PLAU	0.0035
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0035
798	Osteocalcin	BGLAP	0.0035
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0035
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0035
509	Thymidine kinase	TK	0.0035
570	Thymidine kinase	TK	0.0035
2559	Thymidine kinase	TK	0.0035
3430	Thymidine kinase	tdk	0.0035
3518	Thymidine kinase	TK	0.0035
5301	Thymidine kinase	tdk	0.0035
5771	Thymidine kinase	ORF36	0.0035
7009	Thymidine kinase	ORF36	0.0035
869	Estrogen receptor beta	ESR2	0.0035
1341	Histamine H3 receptor	HRH3	0.0034
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0034
6209	30S ribosomal protein S19	rpsS	0.0034
6712	30S ribosomal protein S19	rpsS	0.0034
6726	30S ribosomal protein S19	rpsS	0.0034
6207	30S ribosomal protein S14	rpsN	0.0034
357	Carbonic anhydrase 2	CA2	0.0034
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0034
517	Alcohol dehydrogenase 1C	ADH1C	0.0034
1313	Lactoylglutathione lyase	GLO1	0.0034
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0033
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0033
1525	Heparin-binding growth factor 2	FGF2	0.0033
2249	Aspartate aminotransferase	aspC	0.0033
2671	Aspartate aminotransferase	aspC	0.0033
5490	Aspartate aminotransferase	Not Available	0.0033
4760	Mll3241 protein	mll3241	0.0032
29	Tubulin beta-1 chain	TUBB1	0.0032
164	Histamine H4 receptor	HRH4	0.0032
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0032
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0032
3810	Catechol O-methyltransferase	COMT	0.0032
500	Monocarboxylate transporter 4	SLC16A3	0.0032
1760	Aminopeptidase N	ANPEP	0.0032
6843	Aminopeptidase N	pepN	0.0032
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0032
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0032
369	Coagulation factor VII	F7	0.0032
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0031
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0031
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0031
502	5-hydroxytryptamine 2A receptor	HTR2A	0.003
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
1039	Histone deacetylase 9	HDAC9	0.003
6218	Pannexin-1	PANX1	0.003
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.003
3426	Glutamine synthetase	glnA	0.003
3987	Glutamine synthetase	GLUL	0.003
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0029
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0029
6033	High affinity interleukin-8 receptor A	CXCR1	0.0029
527	Prostacyclin receptor	PTGIR	0.0029
1198	Serum paraoxonase/arylesterase 1	PON1	0.0029
6223	Penicillin-binding protein 1C	pbpC	0.0029
1192	Sulfotransferase 1A1	SULT1A1	0.0029
768	FK506-binding protein 1A	FKBP1A	0.0029
6085	Fatty acid-binding protein, intestinal	FABP2	0.0029
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0029
672	Prostaglandin F2-alpha receptor	PTGFR	0.0028
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0028
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0028
632	Alpha-1B adrenergic receptor	ADRA1B	0.0028
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0028
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0027
867	Penicillin-binding protein 3	pbpC	0.0027
6119	Penicillin-binding protein 3	pbp3	0.0027
7154	Penicillin-binding protein 3	pbp3	0.0027
7157	Penicillin-binding protein 3	LMHCC_2184	0.0027
7162	Penicillin-binding protein 3	pbpB	0.0027
7172	Penicillin-binding protein 3	pbp3	0.0027
1654	Interleukin-1 beta	IL1B	0.0026
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0026
4203	Histamine N-methyltransferase	HNMT	0.0026
5818	Folate receptor alpha	FOLR1	0.0026
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0025
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0025
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0025
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0025
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0025
3856	Fibroblast growth factor receptor 3	FGFR3	0.0025
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0024
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0024
663	Solute carrier family 12 member 4	SLC12A4	0.0024
53	Solute carrier family 12 member 5	SLC12A5	0.0024
1630	Integrin beta-2	ITGB2	0.0024
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0024
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0024
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0023
310	Solute carrier family 12 member 2	SLC12A2	0.0023
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0023
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0023
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0023
293	Gamma-glutamyl hydrolase	GGH	0.0022
6645	D-amino-acid oxidase	DAO	0.0022
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0022
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0022
494	Caspase-1	CASP1	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0022
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
1507	Cytochrome c	CYCS	0.0021
844	Epidermal growth factor receptor	EGFR	0.002
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.002
1650	Heme carrier protein 1	SLC46A1	0.002
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.002
6044	Serum paraoxonase/lactonase 3	PON3	0.002
4878	Glycoprotein hormones alpha chain	CGA	0.002
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.002
1072	Granzyme B	GZMB	0.002
4877	Beta-mannanase	man	0.002
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.002
4850	Beta-2-glycoprotein 1	APOH	0.002
4856	CD209 antigen	CD209	0.002
4889	Ig epsilon chain C region	IGHE	0.002
4869	Major capsid protein	A430L	0.002
4852	Reticulon-4 receptor	RTN4R	0.002
4880	Membrane cofactor protein	CD46	0.002
757	Fusion glycoprotein F0	F	0.002
4875	Fusion glycoprotein F0	F	0.002
4721	Beta-1,4-mannanase	manA	0.002
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.002
1354	Beta-glucuronidase	GUSB	0.002
442	Envelope glycoprotein	gp41	0.002
4859	Envelope glycoprotein	env	0.002
4189	Alpha-galactosidase A	GLA	0.002
4845	ADAM 33	ADAM33	0.002
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.002
3352	Structural polyprotein	Not Available	0.002
3628	Structural polyprotein	Not Available	0.002
4892	Structural polyprotein	Not Available	0.002
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.002
3760	Penicillin-binding protein 5 precursor	dacA	0.0019
489	Monocarboxylate transporter 2	SLC16A7	0.0019
4217	Telomerase reverse transcriptase	TERT	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
572	Integrin alpha-L	ITGAL	0.0018
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0018
2077	Caspase-3	CASP3	0.0018
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0018
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0018
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0018
1517	Beta-3 adrenergic receptor	ADRB3	0.0018
65	Matrix metalloproteinase-9	Not Available	0.0018
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0018
267	Plasminogen activator inhibitor 1	SERPINE1	0.0017
365	Dihydrofolate reductase	DHFR	0.0017
2381	Dihydrofolate reductase	DFR1	0.0017
2833	Dihydrofolate reductase	Not Available	0.0017
2931	Dihydrofolate reductase	folA	0.0017
3544	Dihydrofolate reductase	folA	0.0017
3682	Dihydrofolate reductase	folA	0.0017
6642	Dihydrofolate reductase	folA	0.0017
6756	Dihydrofolate reductase	dfrA	0.0017
819	Penicillin-binding protein 4	dacB	0.0017
504	Mast/stem cell growth factor receptor	KIT	0.0017
6858	Inactive carboxylesterase 4	CES1P1	0.0017
793	T-cell surface antigen CD2	CD2	0.0017
4861	Interleukin-6 receptor alpha chain	IL6R	0.0017
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0017
3837	Cytokine receptor common beta chain	CSF2RB	0.0017
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0017
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0017
4122	Histone deacetylase 2	HDAC2	0.0017
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
6221	Steroid hormone receptor ERR1	ESRRA	0.0016
2021	Thrombomodulin	THBD	0.0016
4890	Hemagglutinin	HA	0.0016
6566	Hemagglutinin	Not Available	0.0016
1379	Interleukin-12 subunit beta	IL12B	0.0016
1184	Interferon beta	IFNB1	0.0015
2320	Thymidine kinase, cytosolic	TK1	0.0015
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0015
2297	Genome polyprotein	Not Available	0.0015
2322	Genome polyprotein	Not Available	0.0015
2694	Genome polyprotein	Not Available	0.0015
2719	Genome polyprotein	Not Available	0.0015
2860	Genome polyprotein	Not Available	0.0015
2928	Genome polyprotein	Not Available	0.0015
3160	Genome polyprotein	Not Available	0.0015
3260	Genome polyprotein	Not Available	0.0015
4783	Genome polyprotein	Not Available	0.0015
5726	Genome polyprotein	Not Available	0.0015
5779	Genome polyprotein	Not Available	0.0015
5867	Genome polyprotein	Not Available	0.0015
6253	Genome polyprotein	Not Available	0.0015
6301	Genome polyprotein	Not Available	0.0015
6380	Genome polyprotein	Not Available	0.0015
6381	Genome polyprotein	Not Available	0.0015
6437	Genome polyprotein	Not Available	0.0015
6520	Genome polyprotein	Not Available	0.0015
6521	Genome polyprotein	Not Available	0.0015
6652	Genome polyprotein	Not Available	0.0015
6734	Genome polyprotein	Not Available	0.0015
6735	Genome polyprotein	Not Available	0.0015
6736	Genome polyprotein	Not Available	0.0015
6737	Genome polyprotein	Not Available	0.0015
6738	Genome polyprotein	Not Available	0.0015
6739	Genome polyprotein	Not Available	0.0015
6744	Genome polyprotein	Not Available	0.0015
6748	Genome polyprotein	Not Available	0.0015
6894	Genome polyprotein	Not Available	0.0015
6898	Genome polyprotein	Not Available	0.0015
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0015
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0015
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0014
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
1859	Prostatic acid phosphatase	ACPP	0.0014
3140	Hemagglutinin-neuraminidase	HN	0.0014
3609	Hemagglutinin-neuraminidase	HN	0.0014
6220	Aryl hydrocarbon receptor	AHR	0.0014
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0014
3444	Cyanovirin-N	Not Available	0.0014
554	Low-density lipoprotein receptor	LDLR	0.0014
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0014
852	Heparin cofactor 2	SERPIND1	0.0014
4787	Envelope glycoprotein gp160	env	0.0013
4820	Envelope glycoprotein gp160	env	0.0013
5727	Envelope glycoprotein gp160	env	0.0013
163	D(1B) dopamine receptor	DRD5	0.0013
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0013
4486	Phenol 2-hydroxylase component B	pheA2	0.0013
4439	Ferredoxin reductase	bphA4	0.0013
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0013
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0013
5117	Dihydrolipoyl dehydrogenase	lpd	0.0013
595	Fibrinogen alpha chain	FGA	0.0013
4666	Fucose-binding lectin PA-IIL	lecB	0.0013
2372	Bifunctional tail protein	9	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
432	D(4) dopamine receptor	DRD4	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
638	D(3) dopamine receptor	DRD3	0.0012
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0012
5122	Mersacidin decarboxylase	mrsD	0.0012
526	Thioredoxin reductase	trxB	0.0012
3767	Thioredoxin reductase	trxB	0.0012
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0012
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0012
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0012
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0012
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0012
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0012
5115	FkbI	fkbI	0.0012
3133	UDP-galactopyranose mutase	glf	0.0012
5099	UDP-galactopyranose mutase	glf	0.0012
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0012
5095	Putidaredoxin reductase	camA	0.0012
5083	Cryptochrome DASH	cry	0.0012
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0012
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0012
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0012
5081	L-aspartate oxidase	nadB	0.0012
5111	Phenylacetone monooxygenase	pamO	0.0012
5109	Outer membrane protein p64k or PM-6	m-6	0.0012
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0012
284	DNA-directed RNA polymerase beta chain	rpoB	0.0012
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0012
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0012
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0012
958	Insulin-like growth factor 1 receptor	IGF1R	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
1243	Cathepsin D	CTSD	0.0011
1439	Lactotransferrin	LTF	0.0011
714	Glutathione reductase, mitochondrial	GSR	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
3102	Flavohemoprotein	hmp	0.0011
4969	Flavohemoprotein	hmp	0.0011
4440	NADH peroxidase	npr	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
23	D(1A) dopamine receptor	DRD1	0.0011
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0011
1792	Tissue-type plasminogen activator	PLAT	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
3814	Complement C1r subcomponent	C1R	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
5072	N,N-dimethylglycine oxidase	dmg	0.0011
5073	Ferredoxin--NADP reductase	petH	0.0011
5076	Ferredoxin--NADP reductase	fpr	0.0011
5119	Ferredoxin--NADP reductase	petH	0.0011
5121	Ferredoxin--NADP reductase	fpr	0.0011
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0011
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0011
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0011
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0011
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0011
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0011
2526	NADPH-ferredoxin reductase fprA	fprA	0.0011
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0011
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0011
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0011
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0011
2470	Pyruvate oxidase	pox5	0.0011
2430	Chondroitinase B	cslB	0.0011
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0011
273	Apoptosis regulator Bcl-2	BCL2	0.0011
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.001
2268	Cholesterol oxidase	choB	0.001
2822	Cholesterol oxidase	choA	0.001
6307	Ig gamma-2 chain C region	IGHG2	0.001
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.001
2581	Chondroitinase AC	cslA	0.001
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
126	D-lactate dehydrogenase	dld	0.001
3545	D-lactate dehydrogenase	Not Available	0.001
4510	D-lactate dehydrogenase	ldhA	0.001
6847	Lactase-phlorizin hydrolase	LCT	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.001
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.001
2893	Glycine oxidase	thiO	0.001
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0009
2207	Rhodopsin	RHO	0.0009
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0009
2567	Thymidylate synthase thyX	thyX	0.0009
2823	Trypanothione reductase	TPR	0.0009
2769	P-hydroxybenzoate hydroxylase	pobA	0.0009
2809	P-hydroxybenzoate hydroxylase	pobA	0.0009
4785	Ig gamma-1 chain C region	IGHG1	0.0009
2380	Monomeric sarcosine oxidase	soxA	0.0008
816	Biliverdin reductase A	BLVRA	0.0007
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0007
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0007
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0007
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0006
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0006
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0006
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0006
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0006
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0006
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0006
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0006
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0006
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0006
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0006
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0006
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0006
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0006
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0006
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0006
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0006
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0006
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0006
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0006
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0006
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0006
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0006
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0006
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0006
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0006
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0006
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0006
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0006
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0006
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0006
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0006
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0006
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0006
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0006
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0006
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0006
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0006
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0006
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0006
729	GDP-L-fucose synthetase	TSTA3	0.0006
3463	GDP-L-fucose synthetase	fcl	0.0006
167	L-lactate dehydrogenase C chain	LDHC	0.0006
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0006
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0006
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0006
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0006
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0006
206	3-keto-steroid reductase	HSD17B7	0.0006
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0006
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0006
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0006
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0006
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0006
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0006
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0006
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0006
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0006
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0006
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0006
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0006
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0006
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0006
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0006
34	7-dehydrocholesterol reductase	DHCR7	0.0006
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0006
711	UDP-glucose 6-dehydrogenase	UGDH	0.0006
3672	UDP-glucose 6-dehydrogenase	hasB	0.0006
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0006
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0006
107	C-4 methylsterol oxidase	SC4MOL	0.0006
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0006
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0006
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0006
643	Peroxisomal bifunctional enzyme	EHHADH	0.0006
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0006
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0006
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0006
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0006
328	Sorbitol dehydrogenase	SORD	0.0006
396	Alcohol dehydrogenase 4	ADH4	0.0006
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0006
597	Dihydropteridine reductase	QDPR	0.0006
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0006
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0006
666	NADP-dependent malic enzyme	ME1	0.0006
857	Malate dehydrogenase, mitochondrial	MDH2	0.0005
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0005
77	L-lactate dehydrogenase B chain	LDHB	0.0005
12	Alcohol dehydrogenase class 3	ADH5	0.0005
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0005
6026	Alcohol dehydrogenase 6	ADH6	0.0005
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0005
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0005
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0005
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0005
626	Cysteine dioxygenase type 1	CDO1	0.0005
627	11-cis retinol dehydrogenase	RDH5	0.0005
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0005
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0005
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0005
473	L-lactate dehydrogenase A chain	LDHA	0.0005
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0005
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0005
569	Retinal dehydrogenase 2	ALDH1A2	0.0005
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0005
13	Aminomethyltransferase, mitochondrial	AMT	0.0005
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0005
611	Retinal dehydrogenase 1	ALDH1A1	0.0005
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0005
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0005
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0005
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0005
251	Alcohol dehydrogenase 1A	ADH1A	0.0005
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0005
279	Tyrosinase	TYR	0.0005
654	Flavin reductase	BLVRB	0.0004
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
444	Alcohol dehydrogenase 1B	ADH1B	0.0004
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0004
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0004
822	Aldose reductase	AKR1B1	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00583 - L-Carnitine

Targets

Transporters

Predictions