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Modification methylase HhaI


Partner ID 4323
Name Modification methylase HhaI
Synonyms 6816
Gene name hhaIM
General function Involved in DNA binding
Specific function This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease
Gene sequence + ...

ATGATTGAAATAAAAGATAAACAGCTCACAGGATTACGCTTTATTGACCTTTTTGCAGGATTAGGTGGCTTTAGACTTGCTTTAGAATCTTGCGGTGCTGAGTGCGTTTATTCTAATGAATGGGATAAATATGCACAAGAAGTATATGAGATGAATTTTGGTGAAAAGCCTGAGGGCGACATTACCCAAGTAAATGAGAAAACCATTCCTGATCACGACATTTTATGTGCAGGGTTTCCGTGCCAAGCGTTTTCTATTAGTGGAAAACAAAAAGGATTCGAGGACAGCAGAGGTACGCTCTTTTTTGATATTGCACGTATTGTCCGTGAAAAAAAACCTAAAGTGGTTTTTATGGAAAATGTGAAAAATTTTGCATCGCATGATAATGGAAATACGTTAGAAGTTGTAAAAAATACAATGAATGAATTGGACTATTCTTTTCATGCTAAAGTATTAAATGCTTTAGATTATGGGATTCCACAGAAAAGGGAACGTATCTATATGATTTGTTTTCGCAATGATCTCAATATTCAAAATTTCCAATTTCCAAAACCTTTTGAGCTTAATACTTTTGTGAAAGATTTGTTATTACCTGATAGCGAGGTGGAACACTTAGTTATTGATAGAAAAGATTTGGTAATGACAAACCAAGAAATTGAGCAAACAACCCCCAAAACAGTTCGACTTGGTATTGTAGGAAAAGGTGGGCAAGGAGAACGAATTTATAGCACAAGAGGCATTGCAATTACCTTATCTGCTTATGGTGGCGGCATTTTCGCTAAGACAGGGGGATATTTAGTAAACGGGAAGACACGGAAATTACACCCTAGAGAGTGTGCTAGAGTAATGGGCTACCCAGATAGTTATAAAGTCCACCCGTCAACCAGCCAAGCATATAAACAATTTGGTAACTCAGTTGTTATCAATGTACTTCAATATATTGCTTATAACATTGGTTCATCATTAAATTTCAAACCATATTAA
Protein sequence + ...

MIEIKDKQLTGLRFIDLFAGLGGFRLALESCGAECVYSNEWDKYAQEVYEMNFGEKPEGDITQVNEKTIPDHDILCAGFPCQAFSISGKQKGFEDSRGTLFFDIARIVREKKPKVVFMENVKNFASHDNGNTLEVVKNTMNELDYSFHAKVLNALDYGIPQKRERIYMICFRNDLNIQNFQFPKPFELNTFVKDLLLPDSEVEHLVIDRKDLVMTNQEIEQTTPKTVRLGIVGKGGQGERIYSTRGIAITLSAYGGGIFAKTGGYLVNGKTRKLHPRECARVMGYPDSYKVHPSTSQAYKQFGNSVVINVLQYIAYNIGSSLNFKPY
GO Classification
function
binding
nucleic acid binding
DNA binding
process
DNA modification
DNA alkylation
DNA methylation
physiological process
metabolism
cellular metabolism
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
DNA metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01752 S-Adenosyl-L-Homocysteine

Associated as Prediction

Id Name
DB00118 S-Adenosylmethionine
DB00145 Glycine
DB00148 Creatine
DB00536 Guanidine
DB00613 Amodiaquine
DB00667 Histamine Phosphate
DB00738 Pentamidine
DB00878 Chlorhexidine
DB01103 Quinacrine
DB01693 Ribavirin Monophosphate
DB01718 Cetyl-Trimethyl-Ammonium
DB01752 S-Adenosyl-L-Homocysteine
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01910 Adenosyl-Ornithine
DB01960 7n-Methyl-8-Hydroguanosine-5'-Diphosphate
DB01978 7,9-Dimethylguanine
DB02282 5'-Deoxy-5'-Methylthioadenosine
DB02751 N-[Amino(Imino)Methyl]Glycine
DB03164 6-Amino-1-Methylpurine
DB03199 4-Methoxy-E-Rhodomycin T
DB03219 11-Deoxy-Beta-Rhodomycin
DB03358 7n-Methyl-8-Hydroguanosine-5'-Triphosphate
DB03468 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide
DB03473 N5-Methylglutamine
DB03493 7-Methylguanosine
DB03824 7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline
DB04077 Glycerol
DB04103 3-Methylcytosine
DB04221 Didecyl-Dimethyl-Ammonium
DB04272 Citric Acid
DB04273 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine
DB04314 1-Methylcytosine
DB04522 Phosphonoserine
DB04655 METOPRINE, METHODICHLOROPHEN
DB07106 4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE
DB07597 CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
DB07739 (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE
DB07747 (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB07798 (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB07906 [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL
DB08128 (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine
DB08129 (1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol
DB08550 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE
DB08631 N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB08654 TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
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