DT-Web: DB00536

Identification

Name

Guanidine

Accession Number

DB00536 (APRD01008, EXPT01546)

Type

small molecule

Description

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Parasympathomimetics

Molecular Weight

59.0705

Groups

approved

Monoisotopic Weight

59.048347175

Pharmacology

Indication

For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.

Mechanism of action

Not Available

Absorption

Rapidly absorbed and distributed

Protein binding

Not Available

Biotransformation

Not metabolized.

Route of elimination

Not Available

Toxicity

LD₅₀ = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Tacrine	The acetylcholinesterase inhibitor, Tacrine, may increase the adverse/toxic effects of Guanidine, a cholinergic agonist. Monitor for increased cholinergic effects and toxicity.

Food Interactions

Not Available

Argininosuccinate synthase
Name	Argininosuccinate synthase
Gene Name	argG
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.0101
Guanidinoacetate N-methyltransferase
Name	Guanidinoacetate N-methyltransferase
Gene Name	GAMT
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Komoto J, Yamada T, Takata Y, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F: Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes. Biochemistry. 2004 Nov 16;43(45):14385-94. - Pubmed Karelin AA, Mardashev SR: [The stimulating effect of cyclic AMP, glucagon and insulin on guanidine acetate-N-methyltransferase activity in rat liver and pancreas] Biokhimiia. 1976 Feb;41(2):316-23. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7189
Ribonuclease pancreatic
Name	Ribonuclease pancreatic
Gene Name	RNASE1
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Dodge RW, Laity JH, Rothwarf DM, Shimotakahara S, Scheraga HA: Folding pathway of guanidine-denatured disulfide-intact wild-type and mutant bovine pancreatic ribonuclease A. J Protein Chem. 1994 May;13(4):409-21. - Pubmed Nasiri H, Forouzandeh M, Rasaee MJ, Rahbarizadeh F: Modified salting-out method: high-yield, high-quality genomic DNA extraction from whole blood using laundry detergent. J Clin Lab Anal. 2005;19(6):229-32. - Pubmed Loh SN, Rohl CA, Kiefhaber T, Baldwin RL: A general two-process model describes the hydrogen exchange behavior of RNase A in unfolding conditions. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1982-7. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.3647
DNA
Name	DNA
Gene Name	Not Available
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	Not Available
Disks large homolog 4
Name	Disks large homolog 4
Gene Name	DLG4
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	Not Available
Lysozyme
Name	Lysozyme
Gene Name	E
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Junn HJ, Youn J, Suh KH, Lee SS: Cloning and expression of Klebsiella phage K11 lysozyme gene. Protein Expr Purif. 2005 Jul;42(1):78-84. Epub 2005 Apr 19. - Pubmed Garcia-Orozco KD, Lopez-Zavala AA, Puentes-Camacho D, Calderon-de-la-Barca AM, Sotelo-Mundo RR: Recombinant bacterial expression of the lysozyme from the tobacco-hornworm Manduca sexta with activity at low temperatures. Biotechnol Lett. 2005 Aug;27(15):1075-80. - Pubmed Shiraki K, Kudou M, Sakamoto R, Yanagihara I, Takagi M: Amino Acid esters prevent thermal inactivation and aggregation of lysozyme. Biotechnol Prog. 2005 Mar-Apr;21(2):640-3. - Pubmed
DTHybrid score	1.6099
Aldehyde dehydrogenase, mitochondrial
Name	Aldehyde dehydrogenase, mitochondrial
Gene Name	ALDH2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.6218
Arginase
Name	Arginase
Gene Name	rocF
Pharmacological action	unknown
Actions	Not Available
References	Not Available
DTHybrid score	0.3196

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. - Pubmed Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.4049
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM: Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). J Biol Chem. 1997 Jun 27;272(26):16548-54. - Pubmed Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. - Pubmed
DTHybrid score	0.4693
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	substrate,inhibitor
References	Wu X, Huang W, Ganapathy ME, Wang H, Kekuda R, Conway SJ, Leibach FH, Ganapathy V: Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. - Pubmed Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V: Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem. 1998 Jun 26;273(26):15971-9. - Pubmed
DTHybrid score	0.3436
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. - Pubmed Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score	0.4589
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
DTHybrid score	0.3323
Organic cation/carnitine transporter 1
Name	Organic cation/carnitine transporter 1
Gene Name	SLC22A4
Actions	inhibitor
References	Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score	0.3582

Id	Partner name	Gene Name	Score
3633	Lysozyme	R	1.6099
5597	Lysozyme	17	1.6099
1729	Solute carrier family 22 member 6	SLC22A6	0.1369
613	Atrial natriuretic peptide receptor A	NPR1	0.1365
4512	Cytochrome P450 3A4	CYP3A4	0.134
4119	Cytochrome P450 2D6	CYP2D6	0.1331
1588	Multidrug resistance protein 1	ABCB1	0.1209
4200	Cytochrome P450 1A2	CYP1A2	0.1046
1024	Solute carrier family 22 member 11	SLC22A11	0.093
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0819
92	Creatine kinase B-type	CKB	0.0728
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0728
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0728
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0728
4757	Cytochrome P450 2C9	CYP2C9	0.0724
6143	Solute carrier family 22 member 7	SLC22A7	0.069
4118	Cytochrome P450 3A5	CYP3A5	0.0661
6016	Cytochrome P450 2C19	CYP2C19	0.0653
6013	Cytochrome P450 2E1	CYP2E1	0.0622
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.062
766	Beta-2 adrenergic receptor	ADRB2	0.0612
788	Creatine kinase M-type	CKM	0.0599
6030	Cytochrome P450 2B6	CYP2B6	0.059
3511	Ribonuclease 4	RNASE4	0.0579
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0552
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0549
6024	Cytochrome P450 1A1	CYP1A1	0.0533
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.053
862	Multidrug resistance-associated protein 1	ABCC1	0.0528
4924	Cytochrome P450 2C8	CYP2C8	0.0487
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0487
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0479
587	Serum albumin	ALB	0.0473
6107	Cytochrome P450 3A7	CYP3A7	0.044
378	Alpha-2C adrenergic receptor	ADRA2C	0.0406
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0406
2390	Nonsecretory ribonuclease	RNASE2	0.0405
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0397
2636	Shikimate dehydrogenase	aroE	0.0384
3515	Shikimate dehydrogenase	aroE	0.0384
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0375
492	Histamine H1 receptor	HRH1	0.0368
2164	Multidrug resistance-associated protein 4	ABCC4	0.0361
4388	Aminoglycoside 2'-N-acetyltransferase	aac	0.036
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0356
776	Bile salt export pump	ABCB11	0.0354
4311	tRNA	TRDMT1	0.0354
4325	tRNA	trmD	0.0354
4328	tRNA	trmD	0.0354
193	Beta-1 adrenergic receptor	ADRB1	0.0353
629	Alpha-2B adrenergic receptor	ADRA2B	0.0348
124	Histamine H2 receptor	HRH2	0.0347
477	DNA topoisomerase 4 subunit A	parC	0.034
886	DNA topoisomerase 4 subunit A	parC	0.034
6226	DNA topoisomerase 4 subunit A	parC	0.034
3116	Bacterioferritin	bfr	0.0338
4906	Bacterioferritin	bfr	0.0338
4965	Bacterioferritin	bfr	0.0338
3709	Glycerol uptake facilitator protein	glpF	0.0338
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0338
3238	Multidrug resistance protein mexA	mexA	0.0338
3173	Enolase	eno	0.0338
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0338
3393	TGF-beta receptor type-2	TGFBR2	0.0338
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0337
404	DNA gyrase subunit A	gyrA	0.0334
6224	DNA gyrase subunit A	gyrA	0.0334
556	Alpha-1A adrenergic receptor	ADRA1A	0.0329
2472	Voltage-gated potassium channel	kcsA	0.0322
6366	Voltage-gated potassium channel	kcsA	0.0322
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0317
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0316
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0316
4031	Glutathione S-transferase A1	GSTA1	0.0315
318	Alpha-2A adrenergic receptor	ADRA2A	0.031
153	Dopamine beta-hydroxylase	DBH	0.0302
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.03
2852	DNA mismatch repair protein mutL	mutL	0.0294
3923	Cholinesterase	BCHE	0.0291
1123	Eosinophil cationic protein	RNASE3	0.0285
3191	Histidinol dehydrogenase	hisD	0.0284
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0281
3221	Cytochrome c4	cc4	0.0273
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0272
6459	Glycodelin	PAEP	0.0271
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0269
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0269
5718	Cytochrome P450 2A6	CYP2A6	0.0266
817	DNA topoisomerase 2-alpha	TOP2A	0.0264
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0264
159	Penicillin-binding protein 2B	penA	0.0255
6121	Penicillin-binding protein 2B	penA	0.0255
738	Monocarboxylate transporter 1	SLC16A1	0.025
6010	Thiamine transporter 1	SLC19A2	0.0248
4692	A/G-specific adenine glycosylase	mutY	0.0248
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0242
3947	Xanthine dehydrogenase/oxidase	XDH	0.0237
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0236
2802	Endoglucanase G	celCCG	0.0236
4203	Histamine N-methyltransferase	HNMT	0.0234
713	Sodium-dependent dopamine transporter	SLC6A3	0.0234
449	Ornithine decarboxylase	ODC1	0.0233
2457	Bacillolysin	nprS	0.0231
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0231
474	Acetylcholinesterase	ACHE	0.0231
131	Synaptic vesicular amine transporter	SLC18A2	0.0231
6316	ADP-ribosylation factor 1	ARF1	0.0229
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0229
175	Thiamin pyrophosphokinase 1	TPK1	0.0222
904	Glutathione S-transferase P	GSTP1	0.0222
444	Alcohol dehydrogenase 1B	ADH1B	0.0222
789	Alpha-1D adrenergic receptor	ADRA1D	0.0218
6136	Multidrug resistance-associated protein 5	ABCC5	0.0217
6106	Cytochrome P450 2C18	CYP2C18	0.0212
632	Alpha-1B adrenergic receptor	ADRA1B	0.0212
5626	Nucleoside diphosphate kinase B	NME2	0.021
3560	Gentamicin 3'-acetyltransferase	aacC1	0.021
6148	Multidrug resistance-associated protein 7	ABCC10	0.0207
2429	Putrescine-binding periplasmic protein	potF	0.0206
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0206
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0205
6141	Sodium/bile acid cotransporter	SLC10A1	0.0205
824	Sodium-dependent serotonin transporter	SLC6A4	0.0202
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0201
831	D(2) dopamine receptor	DRD2	0.0201
3939	Amine oxidase [flavin-containing] B	MAOB	0.0198
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0196
1636	Trace amine-associated receptor 1	TAAR1	0.0195
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0193
3941	Amine oxidase [flavin-containing] A	MAOA	0.0193
465	Calmodulin	CALM1	0.0191
502	5-hydroxytryptamine 2A receptor	HTR2A	0.019
4615	Chain A, Red Copper Protein Nitrosocyanin	NE0143	0.0187
20	Prostaglandin G/H synthase 1	PTGS1	0.0184
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.018
4681	Aminopeptidase	Not Available	0.018
3526	Pseudomonalisin	pcp	0.018
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.018
1898	Cytochrome P450 1B1	CYP1B1	0.0177
1757	Myeloperoxidase	MPO	0.0176
5294	Nucleoside diphosphate kinase A	NME1	0.0175
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0175
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0175
338	DNA polymerase	UL30	0.0173
379	DNA polymerase	UL54	0.0173
697	DNA polymerase	ORF28	0.0173
2482	DNA polymerase	43	0.0173
4104	DNA polymerase	BALF5	0.0173
150	Cationic amino acid transporter 3	SLC7A3	0.0173
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.0173
58	Cationic amino acid transporter 4	SLC7A4	0.0173
6070	Nischarin	NISCH	0.0172
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.017
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0169
23	D(1A) dopamine receptor	DRD1	0.0169
7	Nitric oxide synthase, inducible	NOS2	0.0162
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0161
2392	Biphenyl-2,3-diol 1,2-dioxygenase	bphC	0.0161
3032	Biphenyl-2,3-diol 1,2-dioxygenase	bphC	0.0161
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0159
4773	Deoxycytidine kinase	DCK	0.0158
645	Penicillin-binding protein 1A	mrcA	0.0157
5805	Penicillin-binding protein 1A	ponA	0.0157
6185	Penicillin-binding protein 1A	mrcA	0.0157
6799	Penicillin-binding protein 1A	pbpA	0.0157
672	Prostaglandin F2-alpha receptor	PTGFR	0.0154
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0152
1341	Histamine H3 receptor	HRH3	0.0151
633	Penicillin-binding proteins 1A/1B	pbpA	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
6137	Multidrug resistance-associated protein 6	ABCC6	0.0147
6231	Pepsin A	PGA3	0.0147
756	Sex hormone-binding globulin	SHBG	0.0146
6151	Monocarboxylate transporter 10	SLC16A10	0.0145
164	Histamine H4 receptor	HRH4	0.0145
1998	Protein-L-isoaspartate(D-aspartate) O-methyltransferase	PCMT1	0.0142
4330	Hypothetical protein TTHA0667	TTHA0667	0.0142
4333	Protein-L-isoaspartate O-methyltransferase	pcm	0.0142
2551	Cobalt-precorrin-4 C(11)-methyltransferase	cbiF	0.0142
4313	Probable tRNA/rRNA methyltransferase HI0766	trmL	0.0142
4331	Chemotaxis protein methyltransferase	cheR	0.0142
4309	S-adenosyl-L-methionine-dependent methyltransferase mraW	rsmH	0.0142
4314	Modification methylase PvuII	pvuIIM	0.0142
4324	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7	SETD7	0.0142
4315	DNA adenine methylase	DAM	0.0142
3724	Protein methyltransferase hemK	hemK	0.0142
4329	Uroporphyrinogen-III C-methyltransferase	cobA	0.0142
4316	Mycolic acid synthase	pcaA	0.0142
4323	Modification methylase HhaI	hhaIM	0.0142
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0142
303	Diamine acetyltransferase 2	SAT2	0.0141
1317	Spermine synthase	SMS	0.0141
623	Spermine oxidase	SMOX	0.0141
6014	Cytochrome P450 2A13	CYP2A13	0.0141
290	Prostaglandin G/H synthase 2	PTGS2	0.014
2314	Triosephosphate isomerase	TPI	0.014
3417	Triosephosphate isomerase	tpiA	0.014
3443	Triosephosphate isomerase	tpiA	0.014
6346	Triosephosphate isomerase	TPI1	0.014
5226	Protein ninB	ninB	0.014
4318	Siroheme synthase	cysG	0.0136
828	Phenylalanine-4-hydroxylase	PAH	0.0136
3109	Phenylalanine-4-hydroxylase	phhA	0.0136
1758	GTPase HRas	HRAS	0.0135
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0134
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0134
6432	Transporter	snf	0.0131
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0131
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.013
952	Dipeptidyl peptidase 4	DPP4	0.0129
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0129
2795	Methionine aminopeptidase 2	METAP2	0.0129
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0129
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0127
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0127
123	Diamine acetyltransferase 1	SAT1	0.0127
4604	Liver carboxylesterase 1	CES1	0.0126
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0126
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0125
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0125
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0125
769	High-affinity choline transporter 1	SLC5A7	0.0125
3927	Choline transporter-like protein 3	SLC44A3	0.0125
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0125
1686	Choline transporter-like protein 1	SLC44A1	0.0125
3926	Choline transporter-like protein 2	SLC44A2	0.0125
861	Choline kinase alpha	CHKA	0.0125
700	Choline dehydrogenase, mitochondrial	CHDH	0.0125
3925	Choline transporter-like protein 4	SLC44A4	0.0125
576	Choline O-acetyltransferase	CHAT	0.0125
3922	Phospholipase D2	PLD2	0.0125
3924	Phospholipase D1	PLD1	0.0125
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0125
4306	HemK protein	TM_0488	0.0125
4332	Modification methylase TaqI	taqIM	0.0124
4310	rRNA adenine N-6-methyltransferase	ermC'	0.0123
3117	Carminomycin 4-O-methyltransferase	dnrK	0.0123
4302	METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2	mmaA2	0.0122
2242	Cyclopropane-fatty-acyl-phospholipid synthase 2	cmaA2	0.0122
2297	Genome polyprotein	Not Available	0.0122
2322	Genome polyprotein	Not Available	0.0122
2694	Genome polyprotein	Not Available	0.0122
2719	Genome polyprotein	Not Available	0.0122
2860	Genome polyprotein	Not Available	0.0122
2928	Genome polyprotein	Not Available	0.0122
3160	Genome polyprotein	Not Available	0.0122
3260	Genome polyprotein	Not Available	0.0122
4783	Genome polyprotein	Not Available	0.0122
5726	Genome polyprotein	Not Available	0.0122
5779	Genome polyprotein	Not Available	0.0122
5867	Genome polyprotein	Not Available	0.0122
6253	Genome polyprotein	Not Available	0.0122
6301	Genome polyprotein	Not Available	0.0122
6380	Genome polyprotein	Not Available	0.0122
6381	Genome polyprotein	Not Available	0.0122
6437	Genome polyprotein	Not Available	0.0122
6520	Genome polyprotein	Not Available	0.0122
6521	Genome polyprotein	Not Available	0.0122
6652	Genome polyprotein	Not Available	0.0122
6734	Genome polyprotein	Not Available	0.0122
6735	Genome polyprotein	Not Available	0.0122
6736	Genome polyprotein	Not Available	0.0122
6737	Genome polyprotein	Not Available	0.0122
6738	Genome polyprotein	Not Available	0.0122
6739	Genome polyprotein	Not Available	0.0122
6744	Genome polyprotein	Not Available	0.0122
6748	Genome polyprotein	Not Available	0.0122
6894	Genome polyprotein	Not Available	0.0122
6898	Genome polyprotein	Not Available	0.0122
3766	Pyridoxamine 5'-phosphate oxidase	pdxH	0.0122
1277	Alpha-1-antitrypsin	SERPINA1	0.0122
6500	Phospholipase A2	PLA2G1B	0.0121
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
2826	Glucose--fructose oxidoreductase	gfo	0.0119
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0116
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0116
976	Platelet glycoprotein IX	GP9	0.0115
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0115
1	Peptidoglycan synthetase ftsI	ftsI	0.0115
4155	Peptidoglycan synthetase ftsI	ftsI	0.0115
2016	Dipeptidase 1	DPEP1	0.0115
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0115
4327	RdmB	rdmB	0.0113
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0113
543	Penicillin-binding protein 1B	mrcB	0.0113
6186	Penicillin-binding protein 1B	ponB	0.0113
6822	Penicillin-binding protein 1b	pbp1b	0.0113
6844	Penicillin-binding protein 1b	pbp1b	0.0113
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0113
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0113
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0113
2653	Modification methylase RsrI	rsrIM	0.0113
411	Glycine N-methyltransferase	GNMT	0.0113
221	Lysyl-tRNA synthetase	KARS	0.0112
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0112
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0112
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0111
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0111
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0109
4549	Endonuclease III	HP_0602	0.0106
161	Tubulin beta chain	TUBB	0.0106
312	Tubulin beta chain	TUB2	0.0106
332	Beta-lactamase	blaZ	0.0105
2478	Beta-lactamase	ampC	0.0105
2613	Beta-lactamase	ampC	0.0105
2635	Beta-lactamase	ampC	0.0105
2700	Beta-lactamase	penP	0.0105
5445	Beta-lactamase	blaB	0.0105
6019	Beta-lactamase	SHV-7	0.0105
6701	Beta-lactamase	cphA	0.0105
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0105
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0105
4382	Sulfotransferase family cytosolic 1B member 1	SULT1B1	0.0105
4380	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	NDST1	0.0104
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0102
22	30S ribosomal protein S4	rpsD	0.0101
6714	30S ribosomal protein S4	rpsD	0.0101
740	Argininosuccinate synthase	ASS1	0.0101
865	Argininosuccinate synthase	ASS1	0.0101
2680	Argininosuccinate synthase	argG	0.0101
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
1517	Beta-3 adrenergic receptor	ADRB3	0.0099
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0099
619	Low-affinity cationic amino acid transporter 2	SLC7A2	0.0098
380	Cytochrome P450 17A1	CYP17A1	0.0098
203	Pyridoxine-5'-phosphate oxidase	PNPO	0.0098
136	Estrogen receptor	ESR1	0.0097
6171	Solute carrier family 28 member 3	SLC28A3	0.0097
6168	Solute carrier family 22 member 16	SLC22A16	0.0096
3811	Cytochrome P450 19A1	CYP19A1	0.0096
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0096
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0095
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0095
140	30S ribosomal protein S9	rpsI	0.0095
6719	30S ribosomal protein S9	rpsI	0.0095
6725	30S ribosomal protein S9	rpsI	0.0095
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0094
551	Carnitine O-acetyltransferase	CRAT	0.0094
1313	Lactoylglutathione lyase	GLO1	0.0093
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0092
2557	Cap-specific mRNA	PAPS	0.0092
450	Muscarinic acetylcholine receptor M4	CHRM4	0.009
499	Arginine decarboxylase	ADC	0.0089
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0089
6020	Aldehyde oxidase	AOX1	0.0089
163	D(1B) dopamine receptor	DRD5	0.0088
751	Potassium channel subfamily K member 6	KCNK6	0.0088
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0087
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0087
6167	Organic solute transporter subunit beta	OSTB	0.0086
6166	Organic solute transporter subunit alpha	OSTA	0.0086
694	Matrix protein 2	M	0.0086
577	Argininosuccinate lyase	ASL	0.0085
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0085
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0085
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0085
834	Arginase-2, mitochondrial	ARG2	0.0084
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0084
432	D(4) dopamine receptor	DRD4	0.0084
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0084
974	Phenylethanolamine N-methyltransferase	PNMT	0.0082
737	Mineralocorticoid receptor	NR3C2	0.0082
6149	Solute carrier family 22 member 10	SLC22A10	0.0082
638	D(3) dopamine receptor	DRD3	0.0081
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0081
6165	Copper-transporting ATPase 1	ATP7A	0.008
6163	Copper-transporting ATPase 2	ATP7B	0.008
172	Potassium channel subfamily K member 1	KCNK1	0.008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0079
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0079
702	UMP-CMP kinase	CMPK1	0.0079
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0078
1830	5'-nucleotidase	NT5E	0.0077
6146	High affinity copper uptake protein 1	SLC31A1	0.0077
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0077
125	DNA polymerase beta	POLB	0.0074
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0074
908	Glutathione S-transferase theta-1	GSTT1	0.0073
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0073
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0072
1074	Urokinase-type plasminogen activator	PLAU	0.0071
438	Taste receptor type 1 member 2	TAS1R2	0.0071
3810	Catechol O-methyltransferase	COMT	0.007
1050	Bile salt sulfotransferase	SULT2A1	0.0069
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0068
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0067
558	Solute carrier family 12 member 1	SLC12A1	0.0066
527	Prostacyclin receptor	PTGIR	0.0065
3686	Acyl-CoA thioesterase I precursor	tesA	0.0065
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0065
3611	Cytidine deaminase	cdd	0.0065
3707	Cytidine deaminase	cdd	0.0065
4211	Cytidine deaminase	CDA	0.0065
1192	Sulfotransferase 1A1	SULT1A1	0.0065
1275	Estrogen sulfotransferase	SULT1E1	0.0065
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0065
896	Glutathione S-transferase Mu 1	GSTM1	0.0064
146	Androgen receptor	AR	0.0064
6138	Multidrug resistance protein 3	ABCB4	0.0061
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0061
6218	Pannexin-1	PANX1	0.006
869	Estrogen receptor beta	ESR2	0.0058
6067	Penicillin binding protein 2a	mecA	0.0058
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
887	DNA gyrase subunit B	gyrB	0.0057
4150	DNA gyrase subunit B	gyrB	0.0057
6225	DNA gyrase subunit B	gyrB	0.0057
871	Glucocorticoid receptor	NR3C1	0.0057
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0055
6085	Fatty acid-binding protein, intestinal	FABP2	0.0055
1770	Phospholipase C	PLCL1	0.0055
2841	Phospholipase C	plc	0.0055
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0055
5353	Glutamate decarboxylase alpha	gadA	0.0054
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0053
6031	Cytochrome P450 3A43	CYP3A43	0.0053
291	Nitric-oxide synthase, endothelial	NOS3	0.0052
860	Nicotinamide N-methyltransferase	NNMT	0.0051
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0051
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0051
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0051
699	Nicotinic acid receptor 1	GPR109A	0.0051
928	Nicotinic acid receptor 2	GPR109B	0.0051
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0051
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0051
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.005
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.005
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
731	HIV-1 protease	HIV-1 protease	0.0047
1405	Thiopurine S-methyltransferase	TPMT	0.0047
29	Tubulin beta-1 chain	TUBB1	0.0046
500	Monocarboxylate transporter 4	SLC16A3	0.0045
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0044
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0043
4217	Telomerase reverse transcriptase	TERT	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
357	Carbonic anhydrase 2	CA2	0.0043
2539	Tubulin alpha-1 chain	TUBA4A	0.0042
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0041
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0041
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0041
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0041
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0041
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.004
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.004
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0039
1867	Major prion protein	PRNP	0.0039
614	Progesterone receptor	PGR	0.0039
5482	Sialidase-2	NEU2	0.0039
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0039
489	Monocarboxylate transporter 2	SLC16A7	0.0038
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0038
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0038
3685	Catabolite gene activator	crp	0.0038
4655	Adenylate cyclase	cyaC	0.0038
4759	Adenylate cyclase	cyaB2	0.0038
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0038
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0038
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0037
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0037
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0037
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0037
4533	Glyoxalase family protein	BC_1747	0.0036
723	Cytosolic phospholipase A2	PLA2G4A	0.0036
130	Prostacyclin synthase	PTGIS	0.0036
4496	C-terminal-binding protein 1	CTBP1	0.0035
509	Thymidine kinase	TK	0.0035
570	Thymidine kinase	TK	0.0035
2559	Thymidine kinase	TK	0.0035
3430	Thymidine kinase	tdk	0.0035
3518	Thymidine kinase	TK	0.0035
5301	Thymidine kinase	tdk	0.0035
5771	Thymidine kinase	ORF36	0.0035
7009	Thymidine kinase	ORF36	0.0035
3175	Glutamate--cysteine ligase	gshA	0.0034
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0034
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0034
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0034
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0034
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0034
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0034
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0034
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0034
6559	Cytochrome c oxidase subunit 2	ctaC	0.0034
6669	Cytochrome c oxidase subunit 2	ctaC	0.0034
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0034
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0034
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0034
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0034
6558	Cytochrome c oxidase subunit 1	ctaD	0.0034
6209	30S ribosomal protein S19	rpsS	0.0034
6712	30S ribosomal protein S19	rpsS	0.0034
6726	30S ribosomal protein S19	rpsS	0.0034
6207	30S ribosomal protein S14	rpsN	0.0034
594	Thyroxine-binding globulin	SERPINA7	0.0034
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0034
1864	RET proto-oncogene	RET	0.0034
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0033
2320	Thymidine kinase, cytosolic	TK1	0.0033
3583	6-phosphogluconolactonase	pgl	0.0033
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0033
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0033
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0033
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0033
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0033
277	Purine nucleoside phosphorylase	PNP	0.0033
2870	Purine nucleoside phosphorylase	punA	0.0033
2945	Purine nucleoside phosphorylase	punA	0.0033
4659	Purine nucleoside phosphorylase	TM_1596	0.0033
4825	Purine nucleoside phosphorylase	TTHA1435	0.0033
2249	Aspartate aminotransferase	aspC	0.0033
2671	Aspartate aminotransferase	aspC	0.0033
5490	Aspartate aminotransferase	Not Available	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
4760	Mll3241 protein	mll3241	0.0032
3587	Gastrotropin	FABP6	0.0032
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0032
2632	Adenylosuccinate synthetase	purA	0.0032
3323	Adenylosuccinate synthetase	purA	0.0032
3975	Adenylosuccinate synthetase	ADSS	0.0032
4598	Adenylosuccinate synthetase	Adss	0.0032
6817	Adenylosuccinate synthetase	purA	0.0032
3969	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase	PAICS	0.0032
799	Aspartyl-tRNA synthetase, cytoplasmic	DARS	0.0032
209	Aspartoacylase	ASPA	0.0032
3979	Aspartoacylase-2	ACY3	0.0032
533	Aminoacylase-1	ACY1	0.0032
3972	Adenylosuccinate synthetase isozyme 2	ADSS	0.0032
3976	Aspartyl-tRNA synthetase, mitochondrial	DARS2	0.0032
513	Calcium-binding mitochondrial carrier protein Aralar2	SLC25A13	0.0032
305	Mitochondrial aspartate-glutamate carrier protein	SLC25A13	0.0032
262	Calcium-binding mitochondrial carrier protein Aralar1	SLC25A12	0.0032
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
758	Thyroid hormone receptor alpha	THRA	0.0031
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0031
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0031
3978	Adenylosuccinate synthetase isozyme 1	ADSSL1	0.0031
6212	Tubulin gamma-1 chain	TUBG1	0.0031
6210	Tubulin delta chain	TUBD1	0.0031
6211	Tubulin epsilon chain	TUBE1	0.0031
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0031
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.003
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.003
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.003
1039	Histone deacetylase 9	HDAC9	0.003
3027	Streptavidin	Not Available	0.003
3971	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	CAD	0.003
6033	High affinity interleukin-8 receptor A	CXCR1	0.0029
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0029
1198	Serum paraoxonase/arylesterase 1	PON1	0.0029
6223	Penicillin-binding protein 1C	pbpC	0.0029
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0029
504	Mast/stem cell growth factor receptor	KIT	0.0029
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0028
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0028
6423	Light-harvesting protein B-800/820 alpha chain	Not Available	0.0028
6589	Delta-hemolysin	hld	0.0028
6586	Protein S100-G	S100G	0.0028
6591	ATP synthase C chain	atpH	0.0028
6424	Light-harvesting protein B-800/820 beta chain	Not Available	0.0028
6587	Rubredoxin	rub	0.0028
6592	Probable L-ascorbate-6-phosphate lactonase ulaG	ulaG	0.0028
6585	HLA class I histocompatibility antigen, B-27 alpha chain	HLA-B	0.0028
4718	Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	0.0028
6588	Methionyl-tRNA formyltransferase	fmt	0.0028
6593	Immunoglobulin G-binding protein G	spg	0.0028
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0028
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0028
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0028
346	Thyroid hormone receptor beta-1	THRB	0.0028
373	Transthyretin	TTR	0.0028
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0027
3977	ASRGL1 protein	ASRGL1	0.0027
1618	High affinity nerve growth factor receptor	NTRK1	0.0027
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0027
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0027
816	Biliverdin reductase A	BLVRA	0.0027
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0027
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0027
867	Penicillin-binding protein 3	pbpC	0.0027
6119	Penicillin-binding protein 3	pbp3	0.0027
7154	Penicillin-binding protein 3	pbp3	0.0027
7157	Penicillin-binding protein 3	LMHCC_2184	0.0027
7162	Penicillin-binding protein 3	pbpB	0.0027
7172	Penicillin-binding protein 3	pbp3	0.0027
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0027
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0027
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0027
1654	Interleukin-1 beta	IL1B	0.0026
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0026
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0026
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0026
3877	Growth-inhibiting protein 18	GIG18	0.0025
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0025
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0025
1671	Excitatory amino acid transporter 3	SLC1A1	0.0025
244	Angiotensin-converting enzyme	ACE	0.0025
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0025
857	Malate dehydrogenase, mitochondrial	MDH2	0.0025
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0025
6279	Beta-2-microglobulin	B2M	0.0025
6319	Respiratory nitrate reductase 1 gamma chain	narI	0.0025
6318	Respiratory nitrate reductase 1 beta chain	narH	0.0025
6317	Respiratory nitrate reductase 1 alpha chain	narG	0.0024
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0024
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0024
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0024
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0024
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0024
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0024
663	Solute carrier family 12 member 4	SLC12A4	0.0024
53	Solute carrier family 12 member 5	SLC12A5	0.0024
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0024
1629	Transcription factor AP-1	JUN	0.0024
597	Dihydropteridine reductase	QDPR	0.0024
396	Alcohol dehydrogenase 4	ADH4	0.0024
328	Sorbitol dehydrogenase	SORD	0.0024
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0024
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0024
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0024
275	Arachidonate 5-lipoxygenase	ALOX5	0.0024
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0024
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0024
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0024
4037	Hypothetical protein	GPX1	0.0024
4297	Hypothetical protein	SP_1951	0.0024
4521	Hypothetical protein	BC_2969	0.0024
4540	Hypothetical protein	TM_1070	0.0024
4555	Hypothetical protein	MT1739	0.0024
4569	Hypothetical protein	mshD	0.0024
4578	Hypothetical protein	PA3270	0.0024
4747	Hypothetical protein	PA3967	0.0024
5177	Hypothetical protein	TM_0096	0.0024
5194	Hypothetical protein	PA1204	0.0024
5240	Hypothetical protein	Rv2991	0.0024
5370	Hypothetical protein	TM_1158	0.0024
5710	Hypothetical protein	Tb927.5.1360	0.0024
4522	Arginine N-succinyltransferase subunit alpha	astA	0.0024
4538	Hypothetical protein VC1899	VC_1899	0.0024
4529	Oxalate decarboxylase oxdC	oxdC	0.0024
4527	Putative hydrolase ycdX	ycdX	0.0024
4536	Transcriptional regulator, IclR family	TM_0065	0.0024
2501	Protein ygbM	ygbM	0.0024
4514	Citrate lyase beta subunit-like protein	citE	0.0024
4781	Citrate lyase beta subunit-like protein	DR_1240	0.0024
4524	Mannose-6-phosphate isomerase	yvyI	0.0024
4535	Glutaconyl-CoA decarboxylase subunit alpha	gcdA	0.0024
4545	Molybdopterin-converting factor subunit 2	moaE	0.0024
4547	Iron binding protein FbpA	fbpA	0.0024
4548	Gyrase B	gyrB	0.0024
4546	Aminotransferase, putative	TM_1131	0.0024
658	Para-aminobenzoate synthase component 1	pabB	0.0024
4526	Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein	TM_1223	0.0024
4515	Peripheral plasma membrane protein CASK	CASK	0.0024
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0023
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0023
2683	Mono-ADP-ribosyltransferase C3	C3	0.0023
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0023
310	Solute carrier family 12 member 2	SLC12A2	0.0023
810	Heme oxygenase 1	HMOX1	0.0023
3391	Heme oxygenase 1	pbsA1	0.0023
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0023
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0023
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0023
12	Alcohol dehydrogenase class 3	ADH5	0.0023
77	L-lactate dehydrogenase B chain	LDHB	0.0022
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0022
2449	Tubulin alpha-3 chain	TUBA1A	0.0022
569	Retinal dehydrogenase 2	ALDH1A2	0.0022
494	Caspase-1	CASP1	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
3830	Calreticulin	CALR	0.0022
517	Alcohol dehydrogenase 1C	ADH1C	0.0022
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0022
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0022
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0022
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0022
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0021
473	L-lactate dehydrogenase A chain	LDHA	0.0021
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0021
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0021
6576	Geranylgeranyl transferase type-2 subunit beta	RABGGTB	0.0021
6575	Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	0.0021
611	Retinal dehydrogenase 1	ALDH1A1	0.0021
183	Vascular endothelial growth factor A	VEGFA	0.0021
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0021
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0021
1507	Cytochrome c	CYCS	0.0021
2929	(S)-2-haloacid dehalogenase	dhlB	0.0021
2995	(S)-2-haloacid dehalogenase	Not Available	0.0021
4532	Gephyrin	GPHN	0.0021
4528	Phenazine biosynthesis protein PhzD	phzD1	0.0021
4542	Glutaminase 1	glsA1	0.0021
4544	Glutaminase 1	glsA1	0.0021
3237	Beta-lactamase OXA-2	bla	0.0021
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0021
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0021
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0021
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0021
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0021
3759	Glutathione S-transferase	gst	0.0021
4541	Glutathione S-transferase	GST	0.0021
3261	Signal recognition particle protein	ffh	0.002
4517	Probable butyrate kinase 2	buk2	0.002
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.002
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.002
2697	Uridine-cytidine kinase 2	UCK2	0.002
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.002
844	Epidermal growth factor receptor	EGFR	0.002
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
251	Alcohol dehydrogenase 1A	ADH1A	0.0019
468	Cytochrome P450 4A11	CYP4A11	0.0019
3760	Penicillin-binding protein 5 precursor	dacA	0.0019
2230	Catalase	CAT	0.0019
3249	Catalase	katA	0.0019
3625	Catalase	katA	0.0019
4539	Catalase	katA	0.0019
4941	Catalase	katB	0.0019
2132	Protein S100-B	S100B	0.0019
4423	Levodione reductase	lvr	0.0019
4456	Inorganic polyphosphate/ATP-NAD kinase	ppnK	0.0019
4428	Redox-sensing transcriptional repressor rex	rex	0.0019
4447	Hypothetical protein yhfP	yhfP	0.0019
4449	ADP-ribosyltransferase	Not Available	0.0019
4475	Hypothetical protein Rv0046c/MT0052	ino1	0.0019
4455	Glycerol dehydrogenase	gldA	0.0019
4495	3-oxoacyl-(Acyl carrier protein) reductase	TM_1169	0.0019
4435	L-aspartate dehydrogenase	nadX	0.0019
4466	Glutathione-independent formaldehyde dehydrogenase	fdhA	0.0019
4446	3alpha-hydroxysteroid dehydrogenase/carbonyl reductase	Not Available	0.0019
4487	Transcriptional regulator nadR	nadR	0.0019
4505	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	bphB	0.0019
3735	NAD(P) transhydrogenase subunit alpha part 1	pntAA	0.0019
4500	L-lactate dehydrogenase 2	ldh2	0.0019
4336	Glyceraldehyde 3-phosphate dehydrogenase	Not Available	0.0019
4436	Glyceraldehyde 3-phosphate dehydrogenase	tthHB8IM	0.0019
3381	Alcohol dehydrogenase	Not Available	0.0019
4508	Alcohol dehydrogenase	adhA	0.0019
4414	Dehydrogenase	TT_P0035	0.0019
2350	3-isopropylmalate dehydrogenase	leuB	0.0019
3092	3-isopropylmalate dehydrogenase	leuB	0.0019
4471	CDP-D-glucose-4,6-dehydratase	ascB	0.0019
4418	AGR_L_3209p	AGR_L_3209	0.0019
4507	Alanine dehydrogenase	ald	0.0019
4443	Quinate/shikimate dehydrogenase	ydiB	0.0019
4497	Benzyl alcohol dehydrogenase	xylB	0.0019
4506	Myo-inositol-1-phosphate synthase-related protein	TM_1419	0.0019
4502	Formate dehydrogenase	Not Available	0.0019
3729	Citrate synthase	gltA	0.0019
4575	Citrate synthase	cit	0.0019
4580	Citrate synthase	gltA	0.0019
4451	Vip2Ac	vip2Ac	0.0019
4472	Glucose 1-dehydrogenase	Not Available	0.0019
4467	Alpha-glucosidase, putative	TM_0752	0.0019
4448	L-2-hydroxyisocaproate dehydrogenase	Not Available	0.0019
3467	Methylglyoxal synthase	mgsA	0.0019
2775	Dihydroorotate dehydrogenase	pyrD	0.0019
4531	Putative ketoacyl reductase	actIII	0.0019
467	Delta-type opioid receptor	OPRD1	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
33	Cystine/glutamate transporter	SLC7A11	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
696	Kappa-type opioid receptor	OPRK1	0.0019
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0019
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
6352	Reaction center protein H chain	puhA	0.0019
6456	Reaction center protein H chain	puhA	0.0019
6682	Reaction center protein H chain	puhA	0.0019
6354	Reaction center protein M chain	pufM	0.0019
6455	Reaction center protein M chain	pufM	0.0019
6684	Reaction center protein M chain	pufM	0.0019
6353	Reaction center protein L chain	pufL	0.0019
6454	Reaction center protein L chain	pufL	0.0019
6683	Reaction center protein L chain	pufL	0.0019
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.0019
4192	DNA topoisomerase 2-beta	TOP2B	0.0019
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
2077	Caspase-3	CASP3	0.0018
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0018
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0018
2838	Ribose-5-phosphate isomerase A	rpiA	0.0018
2952	Ribose-5-phosphate isomerase A	rpiA	0.0018
5595	Ribose-5-phosphate isomerase A	rpiA	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
5590	N utilization substance protein B homolog	nusB	0.0018
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0018
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0018
5591	Complement component C8 gamma chain	C8G	0.0018
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0018
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0018
5593	Transferase	Not Available	0.0018
4695	UPF0124 protein yfiH	yfiH	0.0018
5060	Intron-associated endonuclease 1	ITEVIR	0.0018
5588	Cell division protein FtsY	TM_0570	0.0018
5575	Short tail fiber protein	12	0.0018
5600	Pyruvate decarboxylase	pdc	0.0018
5587	Iron(III)-binding periplasmic protein	fbpA	0.0018
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0018
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0018
5581	Beta-fructosidase	bfrA	0.0018
4375	Glutamine synthetase 1	glnA1	0.0018
5580	Hexon protein	PII	0.0018
5574	Invasin	YPTB1668	0.0018
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0018
65	Matrix metalloproteinase-9	Not Available	0.0018
847	Mu-type opioid receptor	OPRM1	0.0018
2525	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0018
3201	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0018
819	Penicillin-binding protein 4	dacB	0.0017
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0017
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0017
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0017
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0017
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0017
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0017
2688	Peptide deformylase	def	0.0017
2708	Peptide deformylase	def	0.0017
3004	Peptide deformylase	def	0.0017
4337	Peptide deformylase	def	0.0017
4338	Peptide deformylase	def	0.0017
5368	Peptide deformylase	def	0.0017
5371	Peptide deformylase	def	0.0017
6375	Peptide deformylase	def	0.0017
6378	Peptide deformylase	def	0.0017
6379	Peptide deformylase	def	0.0017
6776	Peptide deformylase	def	0.0017
6900	Peptide deformylase	def	0.0017
4534	Cytohesin-2	CYTH2	0.0017
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0017
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0017
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0017
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0017
714	Glutathione reductase, mitochondrial	GSR	0.0017
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0017
4269	Hypoxanthine-guanine phosphoribosyltransferase, putative	HGPRTase	0.0016
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0016
2548	Subtilisin Carlsberg	apr	0.0016
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0016
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
571	Melatonin receptor type 1A	MTNR1A	0.0016
362	Melatonin receptor type 1B	MTNR1B	0.0016
822	Aldose reductase	AKR1B1	0.0016
4992	Cytochrome c peroxidase	Not Available	0.0016
4120	NADPH--cytochrome P450 reductase	POR	0.0016
5006	RNASE4 protein	RNASE4	0.0016
2021	Thrombomodulin	THBD	0.0016
2555	Pol polyprotein	pol	0.0016
3242	Pol polyprotein	gag-pol	0.0016
3471	Pol polyprotein	gag-pro-pol	0.0016
5256	Pol polyprotein	pol	0.0016
6469	Pol polyprotein	gag-pol	0.0016
6565	Pol polyprotein	Not Available	0.0016
3132	Tryptophan synthase alpha chain	trpA	0.0016
6568	Tryptophan synthase alpha chain	trpA	0.0016
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0016
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0016
5328	Prostaglandin F synthase	Tb11.02.2310	0.0016
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0016
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0016
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0016
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0016
309	Antithrombin-III	SERPINC1	0.0015
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0015
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0015
4486	Phenol 2-hydroxylase component B	pheA2	0.0015
4439	Ferredoxin reductase	bphA4	0.0015
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0015
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0015
5117	Dihydrolipoyl dehydrogenase	lpd	0.0015
3598	dTDP-4-dehydrorhamnose reductase	rfbD	0.0015
4427	TDP-glucose-4,6-dehydratase	desIV	0.0015
3177	dTDP-glucose 4,6-dehydratase	rfbB	0.0015
4499	dTDP-glucose 4,6-dehydratase	rmlB	0.0015
4503	NADPH-flavin oxidoreductase	frp	0.0015
4482	UDP-galactose 4-epimerase	galE	0.0015
2967	CDP-paratose 2-epimerase	rfbE	0.0015
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0015
2507	Diphtheria toxin	Not Available	0.0015
2538	6-phospho-beta-glucosidase bglT	bglT	0.0015
2393	Maltose-6'-phosphate glucosidase	glvA	0.0015
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0015
2018	Deoxyhypusine synthase	DHPS	0.0015
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0015
4509	Acetoin(diacetyl) reductase	budC	0.0015
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0015
2881	Gamma-aminobutyraldehyde dehydrogenase	prr	0.0015
3401	D-2-hydroxyisocaproate dehydrogenase	Not Available	0.0015
3081	3-dehydroquinate synthase	aroB	0.0015
126	D-lactate dehydrogenase	dld	0.0015
3545	D-lactate dehydrogenase	Not Available	0.0015
4510	D-lactate dehydrogenase	ldhA	0.0015
2591	Urocanate hydratase	hutU	0.0015
2149	Angiogenin	ANG	0.0015
3615	Dihydrodipicolinate reductase	dapB	0.0015
3618	Dihydrodipicolinate reductase	dapB	0.0015
4462	Dihydrodipicolinate reductase	dapB	0.0015
4498	Ornithine cyclodeaminase	PP3533	0.0015
2831	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	Not Available	0.0015
3059	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	fabG3	0.0015
2424	L-lactate dehydrogenase	ldh	0.0015
2641	L-lactate dehydrogenase	Not Available	0.0015
4437	L-lactate dehydrogenase	ldh	0.0015
4442	L-lactate dehydrogenase	ldh	0.0015
1199	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	0.0015
2603	Beta-lactamase II	blm	0.0015
4450	Iota toxin component Ia	Not Available	0.0015
6698	Dehydrogenase/reductase SDR family member 4-like 2	DHRS4L2	0.0015
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0015
2336	2,3-diketo-L-gulonate reductase	dlgD	0.0015
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0014
2521	Cell division protein ftsZ	ftsZ	0.0014
3301	Cell division protein ftsZ	ftsZ	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
199	Monocarboxylate transporter 8	SLC16A2	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
760	Fibroblast growth factor 1	FGF1	0.0014
3486	Fumarate hydratase class II	fumC	0.0014
2942	Sialidase	nanH	0.0014
3546	Sialidase	nedA	0.0014
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0014
4476	Mannitol dehydrogenase	mtlD	0.0014
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0014
63	Malate dehydrogenase	mdh	0.0014
2329	Malate dehydrogenase	mdh	0.0014
3445	Malate dehydrogenase	mdh	0.0014
4420	Malate dehydrogenase	mdh	0.0014
4438	Malate dehydrogenase	mdh	0.0014
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0014
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0013
365	Dihydrofolate reductase	DHFR	0.0013
2381	Dihydrofolate reductase	DFR1	0.0013
2833	Dihydrofolate reductase	Not Available	0.0013
2931	Dihydrofolate reductase	folA	0.0013
3544	Dihydrofolate reductase	folA	0.0013
3682	Dihydrofolate reductase	folA	0.0013
6642	Dihydrofolate reductase	folA	0.0013
6756	Dihydrofolate reductase	dfrA	0.0013
4504	WbpP	Not Available	0.0013
3296	Nicotinamide mononucleotide adenylyltransferase 1	NMNAT1	0.0013
3367	GDP-mannose 6-dehydrogenase	algD	0.0013
4440	NADH peroxidase	npr	0.0013
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0013
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0013
2799	Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	Not Available	0.0013
4343	Alpha-glucosidase	aglA	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
2617	Nitric oxide synthase oxygenase	nos	0.0013
2701	Nitric oxide synthase oxygenase	nos	0.0013
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0013
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0013
2452	Tryptophanyl-tRNA synthetase	trpS	0.0013
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0012
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0012
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0012
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0012
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0012
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0012
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0012
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0012
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0012
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0012
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0012
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0012
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0012
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0012
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0012
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0012
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0012
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0012
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0012
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0012
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0012
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0012
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0012
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0012
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0012
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0012
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0012
644	Heme oxygenase 2	HMOX2	0.0012
4982	Heme oxygenase 2	pbsA2	0.0012
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0012
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0012
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0012
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0012
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0012
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0012
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0012
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0012
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0012
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0012
327	Glutathione reductase	gor	0.0012
5110	Glutathione reductase	GR2	0.0012
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0012
107	C-4 methylsterol oxidase	SC4MOL	0.0012
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0012
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0012
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0012
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0012
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0012
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0012
729	GDP-L-fucose synthetase	TSTA3	0.0012
3463	GDP-L-fucose synthetase	fcl	0.0012
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0012
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0012
167	L-lactate dehydrogenase C chain	LDHC	0.0012
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0012
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0012
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0012
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0012
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0012
206	3-keto-steroid reductase	HSD17B7	0.0012
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0012
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0012
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0012
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0012
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0012
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0012
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0012
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0012
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0012
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0012
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0012
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0012
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0012
34	7-dehydrocholesterol reductase	DHCR7	0.0012
711	UDP-glucose 6-dehydrogenase	UGDH	0.0012
3672	UDP-glucose 6-dehydrogenase	hasB	0.0012
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0012
643	Peroxisomal bifunctional enzyme	EHHADH	0.0012
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0012
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0012
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0012
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0012
3333	Nicotinamide mononucleotide adenylyltransferase 3	NMNAT3	0.0012
76	Nitric-oxide synthase, brain	NOS1	0.0012
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.0012
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.0012
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.0012
5579	Carboxypeptidase B	CPB1	0.0012
3070	Adenosylhomocysteinase	AHCY	0.0012
4424	Adenosylhomocysteinase	PFE1050w	0.0012
6278	Adenosylhomocysteinase	ahcY	0.0012
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
6042	Prostaglandin reductase 2	PTGR2	0.0012
5818	Folate receptor alpha	FOLR1	0.0012
3384	Macrophage migration inhibitory factor	MIF	0.0012
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0012
666	NADP-dependent malic enzyme	ME1	0.0012
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0011
5287	Signaling protein	Not Available	0.0011
5266	Activator of	hgdC	0.0011
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0011
3199	Phosphopantetheine adenylyltransferase	coaD	0.0011
3543	Phosphopantetheine adenylyltransferase	coaD	0.0011
3567	Phosphopantetheine adenylyltransferase	coaD	0.0011
5289	Phosphopantetheine adenylyltransferase	coaD	0.0011
5293	Shikimate kinase 2	aroL	0.0011
5288	Shikimate kinase	aroK	0.0011
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0011
5304	UPF0166 protein TM_0021	TM_0021	0.0011
5292	Putative partitioning protein	TT_C1605	0.0011
2874	Nitrogenase iron protein 1	nifH1	0.0011
4346	Polynucleotide kinase	pseT	0.0011
5277	Preprotein translocase subunit secA	secA	0.0011
5283	D-alanine--D-alanine ligase B	ddlB	0.0011
5281	Plasmid segregation protein parM	parM	0.0011
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0011
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0011
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0011
5299	D-alanine--D-alanine ligase	ddl	0.0011
6598	D-alanine--D-alanine ligase	ddl	0.0011
5284	Large T antigen	Not Available	0.0011
5285	Kinesin heavy chain	KIF5B	0.0011
5259	Transcriptional regulator	ntrC1	0.0011
6699	Transcriptional regulator	Cgl2612	0.0011
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0011
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0011
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0011
5291	Glycogen synthase 1	glgA1	0.0011
5264	DNA replication protein	REP	0.0011
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0011
5315	Chaperone protein htpG	htpG	0.0011
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0011
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0011
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0011
5308	Preprotein translocase secA 1 subunit	secA1	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
2391	Ferrochelatase	hemH	0.0011
6502	Ferrochelatase	DKFZp686P18130	0.0011
1591	Ferrochelatase, mitochondrial	FECH	0.0011
1792	Tissue-type plasminogen activator	PLAT	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0011
128	Adenine phosphoribosyltransferase	APRT	0.0011
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0011
6043	Putative G-protein coupled receptor 44	GPR44	0.0011
2286	Isocitrate dehydrogenase [NADP]	icd	0.0011
2302	Isocitrate dehydrogenase [NADP]	icd	0.0011
2771	Isocitrate dehydrogenase [NADP]	icd	0.0011
4491	DNA ligase, NAD-dependent	ligA	0.0011
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0011
273	Apoptosis regulator Bcl-2	BCL2	0.0011
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0011
6026	Alcohol dehydrogenase 6	ADH6	0.001
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.001
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.001
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.001
627	11-cis retinol dehydrogenase	RDH5	0.001
626	Cysteine dioxygenase type 1	CDO1	0.001
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.001
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.001
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.001
2762	UDP-glucose 4-epimerase	GALE	0.001
3461	UDP-glucose 4-epimerase	galE	0.001
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
13	Aminomethyltransferase, mitochondrial	AMT	0.001
293	Gamma-glutamyl hydrolase	GGH	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.001
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
3426	Glutamine synthetase	glnA	0.001
3987	Glutamine synthetase	GLUL	0.001
3470	Hypothetical protein MG245 homolog	MPN_348	0.001
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.001
2270	Dephospho-CoA kinase	coaE	0.001
5646	Galactokinase	GALK1	0.001
4774	NTPase P4	Not Available	0.001
4106	Guanylate kinase	GUK1	0.001
4516	Guanylate kinase	gmk	0.001
2284	Adenylate kinase	adk	0.001
2296	Adenylate kinase	adk	0.001
2311	Adenylate kinase	adk	0.001
2312	Adenylate kinase	Not Available	0.001
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.001
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.001
5302	TrwB	trwB	0.001
4837	Cag-alfa	cag-alfa	0.001
5189	Trimethylamine dehydrogenase	tmd	0.001
5265	FtsH	ftsH	0.001
4839	DNA polymerase III subunit tau	dnaX	0.001
6277	Heat shock cognate 71 kDa protein	HSPA8	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
4838	PMS1 protein homolog 2	PMS2	0.001
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.001
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0009
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0009
654	Flavin reductase	BLVRB	0.0009
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0009
279	Tyrosinase	TYR	0.0009
1650	Heme carrier protein 1	SLC46A1	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0009
2922	Glycerol kinase	glpK	0.0009
5271	Focal adhesion kinase 1	PTK2	0.0009
5312	Kinesin-like protein KIF1A	KIF1A	0.0009
2540	Choloylglycine hydrolase	cbh	0.0009
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0009
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0009
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0009
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0009
340	Apoptotic protease-activating factor 1	APAF1	0.0008
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0008
6501	Fatty acid-binding protein, liver	FABP1	0.0008
2892	Acetylglutamate kinase	argB	0.0008
3550	Acetylglutamate kinase	argB	0.0008
2371	Pantothenate kinase	coaA	0.0008
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0008
3669	Ribokinase	rbsK	0.0008
825	Arsenical pump-driving ATPase	ASNA1	0.0008
3435	Arsenical pump-driving ATPase	arsA	0.0008
2615	Chemotaxis protein cheA	cheA	0.0008
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0008
1881	Hexokinase-1	HK1	0.0008
2282	Protein recA	recA	0.0008
2315	Protein recA	recA	0.0008
2332	Protein recA	recA	0.0008
5263	Protein recA	recA	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
408	Riboflavin kinase	RFK	0.0008
2727	S-adenosylmethionine synthetase	metK	0.0008
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0008
5300	Antigen peptide transporter 1	TAP1	0.0008
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0008
2334	Dethiobiotin synthetase	bioD	0.0008
6555	Dethiobiotin synthetase	bioD	0.0008
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0008
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0008
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0008
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0007
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0007
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0007
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0007
3809	Estrogen-related receptor gamma	ESRRG	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0007
6395	Myosin-14	MYH14	0.0007
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0007
2091	Endoplasmin	HSP90B1	0.0007
48	Pyridoxal kinase	PDXK	0.0007
1422	Serine/threonine-protein kinase 6	AURKA	0.0007
24	Thymidylate synthase	TMP1	0.0007
359	Thymidylate synthase	TYMS	0.0007
2626	Thymidylate synthase	thyA	0.0007
2729	Thymidylate synthase	thyA	0.0007
5352	Thymidylate synthase	THYA	0.0007
3379	Kinesin-like protein KIF11	KIF11	0.0007
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0007
3822	Actin, alpha skeletal muscle	ACTA1	0.0006
207	Glutathione synthetase	GSS	0.0006
5269	Glutathione synthetase	gshB	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0006
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00536 - Guanidine

Targets

Transporters

Predictions