DT-Web: DB01103

Identification

Name

Quinacrine

Accession Number

DB01103 (APRD00317)

Type

small molecule

Description

An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

399.957

Groups

approved

Monoisotopic Weight

399.207740304

Pharmacology

Indication

For the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions.

Mechanism of action

The exact mechanism of antiparasitic action is unknown; however, quinacrine binds to deoxyribonucleic acid (DNA) in vitro by intercalation between adjacent base pairs, inhibiting transcription and translation to ribonucleic acid (RNA). Quinacrine does not appear to localize to the nucleus of Giaridia trophozoites, suggesting that DNA binding may not be the primary mechanism of its antimicrobial action. Fluorescence studies using Giardia suggest that the outer membranes may be involved. Quinacrine inhibits succinate oxidation and interferes with electron transport. In addition, by binding to nucleoproteins, quinacrine suppress the lupus erythematous cell factor and acts as a strong inhibitor of cholinesterase.

Absorption

Absorbed rapidly from the gastrointestinal tract following oral administration.

Protein binding

80-90%

Biotransformation

Not Available

Route of elimination

Not Available

Toxicity

Oral, rat: LD₅₀ = 900 mg/kg; Oral, mouse: LD₅₀ = 1000 mg/kg. Symptoms of overdose include seizures, hypotension, cardiac arrhythmias, and cardiovascular collapse.

Affected organisms

Parasitic protozoa and helminths

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atomoxetine	The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine

Food Interactions

Not Available

DNA
Name	DNA
Gene Name	Not Available
Pharmacological action	yes
Actions	intercalation
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Hossain M, Giri P, Suresh Kumar G: DNA Intercalation by Quinacrine and Methylene Blue: A Comparative Binding and Thermodynamic Characterization Study. DNA Cell Biol. 2007 Oct 9;. - Pubmed
DTHybrid score	Not Available
85 kDa calcium-independent phospholipase A2
Name	85 kDa calcium-independent phospholipase A2
Gene Name	PLA2G6
Pharmacological action	yes
Actions	inhibitor
References	Nuttle LC, Ligon AL, Farrell KR, Hester RL: Inhibition of phospholipase A2 attenuates functional hyperemia in the hamster cremaster muscle. Am J Physiol. 1999 Apr;276(4 Pt 2):H1289-94. - Pubmed Sastry BV, Hemontolor ME, Vidaver PS, Sastry WS, Janson VE: Influence of halothane on phospholipase A2 and enzymatic methylations in the rat retinal membranes. J Ocul Pharmacol Ther. 1999 Apr;15(2):165-78. - Pubmed Lohmann CH, Sagun R Jr, Sylvia VL, Cochran DL, Dean DD, Boyan BD, Schwartz Z: Surface roughness modulates the response of MG63 osteoblast-like cells to 1,25-(OH)(2)D(3) through regulation of phospholipase A(2) activity and activation of protein kinase A. J Biomed Mater Res. 1999 Nov;47(2):139-51. - Pubmed Schwartz Z, Sylvia VL, Del Toro F, Hardin RR, Dean DD, Boyan BD: 24R,25-(OH)(2)D(3) mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A(2) and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes. J Cell Physiol. 2000 Mar;182(3):390-401. - Pubmed Sylvia VL, Del Toro F, Dean DD, Hardin RR, Schwartz Z, Boyan BD: Effects of 1alpha,25-(OH)(2)D(3) on rat growth zone chondrocytes are mediated via cyclooxygenase-1 and phospholipase A(2). J Cell Biochem Suppl. 2001;Suppl 36:32-45. - Pubmed
DTHybrid score	0.5247
Cytosolic phospholipase A2
Name	Cytosolic phospholipase A2
Gene Name	PLA2G4A
Pharmacological action	yes
Actions	inhibitor
References	Hellstrand M, Eriksson E, Nilsson CL: Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent. Biochem Pharmacol. 2002 Jun 15;63(12):2151-8. - Pubmed Ong WY, Lu XR, Ong BK, Horrocks LA, Farooqui AA, Lim SK: Quinacrine abolishes increases in cytoplasmic phospholipase A2 mRNA levels in the rat hippocampus after kainate-induced neuronal injury. Exp Brain Res. 2003 Feb;148(4):521-4. Epub 2002 Dec 11. - Pubmed Kim BC, Kim JH: Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway. Biochem J. 1998 Mar 1;330 ( Pt 2):1009-14. - Pubmed
DTHybrid score	0.5862
Phospholipase C
Name	Phospholipase C
Gene Name	PLCL1
Pharmacological action	yes
Actions	inhibitor
References	Biondi C, Pavan B, Ferretti ME, Corradini FG, Neri LM, Vesce F: Formyl-methionyl-leucyl-phenylalanine induces prostaglandin E2 release from human amnion-derived WISH cells by phospholipase C-mediated [Ca+]i rise. Biol Reprod. 2001 Mar;64(3):865-70. - Pubmed Takuwa N, Kumada M, Yamashita K, Takuwa Y: Mechanisms of bombesin-induced arachidonate mobilization in Swiss 3T3 fibroblasts. J Biol Chem. 1991 Aug 5;266(22):14237-43. - Pubmed Otamiri T: Phospholipase C-mediated intestinal mucosal damage is ameliorated by quinacrine. Food Chem Toxicol. 1989 Jun;27(6):399-402. - Pubmed Noveral JP, Grunstein MM: Tachykinin regulation of airway smooth muscle cell proliferation. Am J Physiol. 1995 Sep;269(3 Pt 1):L339-43. - Pubmed Bjoro T, Englund K, Torjesen PA, Haug E: Inhibitors of the arachidonic acid metabolism attenuate the thyroliberin (TRH) stimulated prolactin production without modifying the production of inositolphosphates in GH4C1 pituitary cells. Scand J Clin Lab Invest. 1993 Apr;53(2):111-6. - Pubmed
DTHybrid score	0.5246

Histamine N-methyltransferase
Name	Histamine N-methyltransferase
Gene Name	HNMT
Actions	inhibitor
References	Grassmann S, Apelt J, Sippl W, Ligneau X, Pertz HH, Zhao YH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H: Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities. Bioorg Med Chem. 2003 May 15;11(10):2163-74. - Pubmed Grassmann S, Apelt J, Sippl W, Ligneau X, Pertz HH, Zhao YH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H: Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities. Bioorg Med Chem. 2003 May 15;11(10):2163-74. - Pubmed Hui JY, Taylor SL: Inhibition of in vivo histamine metabolism in rats by foodborne and pharmacologic inhibitors of diamine oxidase, histamine N-methyltransferase, and monoamine oxidase. Toxicol Appl Pharmacol. 1985 Nov;81(2):241-9. - Pubmed
DTHybrid score	0.8622
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5489
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3698

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Sweet DH, Pritchard JB: rOCT2 is a basolateral potential-driven carrier, not an organic cation/proton exchanger. Am J Physiol. 1999 Dec;277(6 Pt 2):F890-8. - Pubmed Dohgu S, Yamauchi A, Takata F, Sawada Y, Higuchi S, Naito M, Tsuruo T, Shirabe S, Niwa M, Katamine S, Kataoka Y: Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier. Cell Mol Neurobiol. 2004 Apr;24(2):205-17. - Pubmed Beck WT, Cirtain MC, Glover CJ, Felsted RL, Safa AR: Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine. Biochem Biophys Res Commun. 1988 Jun 30;153(3):959-66. - Pubmed
DTHybrid score	0.3112
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Tiberghien F, Loor F: Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay. Anticancer Drugs. 1996 Jul;7(5):568-78. - Pubmed
DTHybrid score	0.4281

Id	Partner name	Gene Name	Score
2841	Phospholipase C	plc	0.5246
4119	Cytochrome P450 2D6	CYP2D6	0.1763
6107	Cytochrome P450 3A7	CYP3A7	0.1544
4757	Cytochrome P450 2C9	CYP2C9	0.1383
6016	Cytochrome P450 2C19	CYP2C19	0.1262
4924	Cytochrome P450 2C8	CYP2C8	0.1158
4200	Cytochrome P450 1A2	CYP1A2	0.1144
6145	Solute carrier family 22 member 1	SLC22A1	0.1024
2417	Chloramphenicol acetyltransferase	cat	0.1021
3278	Chloramphenicol acetyltransferase	cat	0.1021
1193	Proteinase-activated receptor 1	F2R	0.0777
6030	Cytochrome P450 2B6	CYP2B6	0.0736
6024	Cytochrome P450 1A1	CYP1A1	0.0729
871	Glucocorticoid receptor	NR3C1	0.0691
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0659
6013	Cytochrome P450 2E1	CYP2E1	0.0641
1729	Solute carrier family 22 member 6	SLC22A6	0.0619
862	Multidrug resistance-associated protein 1	ABCC1	0.0588
232	Corticosteroid-binding globulin	SERPINA6	0.0569
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0519
6147	Solute carrier family 22 member 3	SLC22A3	0.0518
118	Organic cation/carnitine transporter 2	SLC22A5	0.048
587	Serum albumin	ALB	0.0473
234	Plasminogen	PLG	0.0448
1898	Cytochrome P450 1B1	CYP1B1	0.0436
492	Histamine H1 receptor	HRH1	0.0412
617	Muscarinic acetylcholine receptor M2	CHRM2	0.04
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0394
5718	Cytochrome P450 2A6	CYP2A6	0.0391
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0388
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0385
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0375
6020	Aldehyde oxidase	AOX1	0.0372
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0367
817	DNA topoisomerase 2-alpha	TOP2A	0.0362
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0352
1757	Myeloperoxidase	MPO	0.0342
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.033
20	Prostaglandin G/H synthase 1	PTGS1	0.0329
6116	Gastric triacylglycerol lipase	LIPF	0.0314
776	Bile salt export pump	ABCB11	0.0314
290	Prostaglandin G/H synthase 2	PTGS2	0.0313
556	Alpha-1A adrenergic receptor	ADRA1A	0.0309
6142	Solute carrier family 22 member 8	SLC22A8	0.0307
124	Histamine H2 receptor	HRH2	0.03
766	Beta-2 adrenergic receptor	ADRB2	0.0297
1295	Fatty acid synthase	FASN	0.0291
824	Sodium-dependent serotonin transporter	SLC6A4	0.0285
754	Pancreatic triacylglycerol lipase	PNLIP	0.028
833	Organic cation/carnitine transporter 1	SLC22A4	0.0278
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0278
193	Beta-1 adrenergic receptor	ADRB1	0.0276
614	Progesterone receptor	PGR	0.0273
3823	Cytokine receptor common gamma chain	IL2RG	0.0266
831	D(2) dopamine receptor	DRD2	0.026
737	Mineralocorticoid receptor	NR3C2	0.0248
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0246
3811	Cytochrome P450 19A1	CYP19A1	0.0234
6106	Cytochrome P450 2C18	CYP2C18	0.0232
724	Interleukin-2 receptor alpha chain	IL2RA	0.0232
717	Interleukin-2 receptor subunit beta	IL2RB	0.0231
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.023
1341	Histamine H3 receptor	HRH3	0.0228
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0225
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0223
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0222
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0222
318	Alpha-2A adrenergic receptor	ADRA2A	0.0221
6143	Solute carrier family 22 member 7	SLC22A7	0.022
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0219
3923	Cholinesterase	BCHE	0.0213
847	Mu-type opioid receptor	OPRM1	0.021
164	Histamine H4 receptor	HRH4	0.0209
136	Estrogen receptor	ESR1	0.0205
4165	P2Y purinoceptor 2	P2RY2	0.0198
632	Alpha-1B adrenergic receptor	ADRA1B	0.0197
814	Ryanodine receptor 1	RYR1	0.0195
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0192
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0192
3947	Xanthine dehydrogenase/oxidase	XDH	0.0184
738	Monocarboxylate transporter 1	SLC16A1	0.0181
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0181
430	Follicle-stimulating hormone receptor	FSHR	0.0179
731	HIV-1 protease	HIV-1 protease	0.0178
378	Alpha-2C adrenergic receptor	ADRA2C	0.0173
6148	Multidrug resistance-associated protein 7	ABCC10	0.0169
789	Alpha-1D adrenergic receptor	ADRA1D	0.0167
629	Alpha-2B adrenergic receptor	ADRA2B	0.0165
6031	Cytochrome P450 3A43	CYP3A43	0.0165
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0164
467	Delta-type opioid receptor	OPRD1	0.0163
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0161
2654	Complement control protein	C3L	0.0161
23	D(1A) dopamine receptor	DRD1	0.0156
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0156
489	Monocarboxylate transporter 2	SLC16A7	0.0155
6182	Cytochrome P450 2J2	CYP2J2	0.0153
2164	Multidrug resistance-associated protein 4	ABCC4	0.0153
6137	Multidrug resistance-associated protein 6	ABCC6	0.0152
713	Sodium-dependent dopamine transporter	SLC6A3	0.0151
1024	Solute carrier family 22 member 11	SLC22A11	0.0148
638	D(3) dopamine receptor	DRD3	0.0146
5455	Arylsulfatase A	ARSA	0.0146
260	Cytochrome P450 51	ERG11	0.0144
761	Cytochrome P450 51	ERG11	0.0144
3163	Cytochrome P450 51	cyp51	0.0144
6500	Phospholipase A2	PLA2G1B	0.0143
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0143
696	Kappa-type opioid receptor	OPRK1	0.0139
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0138
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0137
477	DNA topoisomerase 4 subunit A	parC	0.0134
886	DNA topoisomerase 4 subunit A	parC	0.0134
6226	DNA topoisomerase 4 subunit A	parC	0.0134
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0134
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0133
404	DNA gyrase subunit A	gyrA	0.0132
6224	DNA gyrase subunit A	gyrA	0.0132
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0129
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0128
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0126
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0126
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0126
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0126
54	Prothrombin	F2	0.0126
7	Nitric oxide synthase, inducible	NOS2	0.0124
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0123
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0123
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0123
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0123
474	Acetylcholinesterase	ACHE	0.0122
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0121
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0119
844	Epidermal growth factor receptor	EGFR	0.0118
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0114
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0113
465	Calmodulin	CALM1	0.0112
468	Cytochrome P450 4A11	CYP4A11	0.0104
4604	Liver carboxylesterase 1	CES1	0.0103
161	Tubulin beta chain	TUBB	0.0103
312	Tubulin beta chain	TUB2	0.0103
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0103
6136	Multidrug resistance-associated protein 5	ABCC5	0.0103
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0102
504	Mast/stem cell growth factor receptor	KIT	0.0102
818	50S ribosomal protein L10	rplJ	0.0101
4773	Deoxycytidine kinase	DCK	0.01
3939	Amine oxidase [flavin-containing] B	MAOB	0.0099
756	Sex hormone-binding globulin	SHBG	0.0099
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0097
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0096
432	D(4) dopamine receptor	DRD4	0.0096
952	Dipeptidyl peptidase 4	DPP4	0.0095
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
29	Tubulin beta-1 chain	TUBB1	0.0093
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0093
4311	tRNA	TRDMT1	0.0093
4325	tRNA	trmD	0.0093
4328	tRNA	trmD	0.0093
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0092
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0092
6141	Sodium/bile acid cotransporter	SLC10A1	0.0091
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0089
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0089
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0089
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0089
1998	Protein-L-isoaspartate(D-aspartate) O-methyltransferase	PCMT1	0.0088
4330	Hypothetical protein TTHA0667	TTHA0667	0.0088
2551	Cobalt-precorrin-4 C(11)-methyltransferase	cbiF	0.0088
3724	Protein methyltransferase hemK	hemK	0.0088
4313	Probable tRNA/rRNA methyltransferase HI0766	trmL	0.0088
4316	Mycolic acid synthase	pcaA	0.0088
4309	S-adenosyl-L-methionine-dependent methyltransferase mraW	rsmH	0.0088
4333	Protein-L-isoaspartate O-methyltransferase	pcm	0.0088
4323	Modification methylase HhaI	hhaIM	0.0088
4324	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7	SETD7	0.0088
4315	DNA adenine methylase	DAM	0.0088
4329	Uroporphyrinogen-III C-methyltransferase	cobA	0.0088
4331	Chemotaxis protein methyltransferase	cheR	0.0088
4314	Modification methylase PvuII	pvuIIM	0.0088
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0087
6010	Thiamine transporter 1	SLC19A2	0.0086
624	Guanidinoacetate N-methyltransferase	GAMT	0.0086
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0086
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0085
122	P2Y purinoceptor 12	P2RY12	0.0084
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0084
4120	NADPH--cytochrome P450 reductase	POR	0.0084
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0083
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0083
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0083
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0083
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0083
3941	Amine oxidase [flavin-containing] A	MAOA	0.0083
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0081
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.008
407	Vascular endothelial growth factor receptor 2	KDR	0.008
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.008
146	Androgen receptor	AR	0.0079
869	Estrogen receptor beta	ESR2	0.0079
2449	Tubulin alpha-3 chain	TUBA1A	0.0078
26	Vascular endothelial growth factor receptor 3	FLT4	0.0078
777	Tumor necrosis factor	TNF	0.0078
4318	Siroheme synthase	cysG	0.0077
4332	Modification methylase TaqI	taqIM	0.0077
4310	rRNA adenine N-6-methyltransferase	ermC'	0.0077
3117	Carminomycin 4-O-methyltransferase	dnrK	0.0077
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0077
175	Thiamin pyrophosphokinase 1	TPK1	0.0077
4237	50S ribosomal protein L22	rplV	0.0076
4302	METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2	mmaA2	0.0076
2242	Cyclopropane-fatty-acyl-phospholipid synthase 2	cmaA2	0.0076
4306	HemK protein	TM_0488	0.0076
2297	Genome polyprotein	Not Available	0.0076
2322	Genome polyprotein	Not Available	0.0076
2694	Genome polyprotein	Not Available	0.0076
2719	Genome polyprotein	Not Available	0.0076
2860	Genome polyprotein	Not Available	0.0076
2928	Genome polyprotein	Not Available	0.0076
3160	Genome polyprotein	Not Available	0.0076
3260	Genome polyprotein	Not Available	0.0076
4783	Genome polyprotein	Not Available	0.0076
5726	Genome polyprotein	Not Available	0.0076
5779	Genome polyprotein	Not Available	0.0076
5867	Genome polyprotein	Not Available	0.0076
6253	Genome polyprotein	Not Available	0.0076
6301	Genome polyprotein	Not Available	0.0076
6380	Genome polyprotein	Not Available	0.0076
6381	Genome polyprotein	Not Available	0.0076
6437	Genome polyprotein	Not Available	0.0076
6520	Genome polyprotein	Not Available	0.0076
6521	Genome polyprotein	Not Available	0.0076
6652	Genome polyprotein	Not Available	0.0076
6734	Genome polyprotein	Not Available	0.0076
6735	Genome polyprotein	Not Available	0.0076
6736	Genome polyprotein	Not Available	0.0076
6737	Genome polyprotein	Not Available	0.0076
6738	Genome polyprotein	Not Available	0.0076
6739	Genome polyprotein	Not Available	0.0076
6744	Genome polyprotein	Not Available	0.0076
6748	Genome polyprotein	Not Available	0.0076
6894	Genome polyprotein	Not Available	0.0076
6898	Genome polyprotein	Not Available	0.0076
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0075
811	Translocator protein	TSPO	0.0075
32	Vascular endothelial growth factor receptor 1	FLT1	0.0075
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0075
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0074
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0074
131	Synaptic vesicular amine transporter	SLC18A2	0.0074
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0073
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0073
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0073
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0073
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0073
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0073
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0073
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0073
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0072
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0072
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0071
2653	Modification methylase RsrI	rsrIM	0.0071
4327	RdmB	rdmB	0.007
1353	DNA topoisomerase 1	TOP1	0.007
3552	DNA topoisomerase 1	topA	0.007
1517	Beta-3 adrenergic receptor	ADRB3	0.0069
244	Angiotensin-converting enzyme	ACE	0.0068
716	5-hydroxytryptamine 7 receptor	HTR7	0.0068
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0068
380	Cytochrome P450 17A1	CYP17A1	0.0067
768	FK506-binding protein 1A	FKBP1A	0.0067
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0067
705	Glutamate receptor 1	GRIA1	0.0067
163	D(1B) dopamine receptor	DRD5	0.0067
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0066
1192	Sulfotransferase 1A1	SULT1A1	0.0066
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0065
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0065
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0065
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0063
4238	50S ribosomal protein L4	rplD	0.0063
5578	50S ribosomal protein L4	rplD	0.0063
6173	50S ribosomal protein L4	rplD	0.0063
6219	50S ribosomal protein L4	rplD	0.0063
2539	Tubulin alpha-1 chain	TUBA4A	0.0062
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0062
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0062
1656	CYP2B protein	CYP2B	0.0061
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0061
6220	Aryl hydrocarbon receptor	AHR	0.0061
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.006
411	Glycine N-methyltransferase	GNMT	0.006
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.006
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
694	Matrix protein 2	M	0.0059
70	Type-1 angiotensin II receptor	AGTR1	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
239	Coagulation factor X	F10	0.0058
2557	Cap-specific mRNA	PAPS	0.0058
1852	Microtubule-associated protein 2	MAP2	0.0058
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0057
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0057
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0056
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0056
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0056
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0056
904	Glutathione S-transferase P	GSTP1	0.0055
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0054
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0053
1629	Transcription factor AP-1	JUN	0.0053
974	Phenylethanolamine N-methyltransferase	PNMT	0.0053
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0052
5300	Antigen peptide transporter 1	TAP1	0.0051
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
3611	Cytidine deaminase	cdd	0.005
3707	Cytidine deaminase	cdd	0.005
4211	Cytidine deaminase	CDA	0.005
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0049
1830	5'-nucleotidase	NT5E	0.0049
4192	DNA topoisomerase 2-beta	TOP2B	0.0049
153	Dopamine beta-hydroxylase	DBH	0.0048
6070	Nischarin	NISCH	0.0048
908	Glutathione S-transferase theta-1	GSTT1	0.0047
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0047
427	Substance-P receptor	TACR1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
1010	Cytochrome P450 51A1	CYP51A1	0.0047
125	DNA polymerase beta	POLB	0.0047
683	Potassium transporter	GK0582	0.0047
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0047
165	FL cytokine receptor	FLT3	0.0046
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0046
976	Platelet glycoprotein IX	GP9	0.0046
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0046
68	Cannabinoid receptor 1	CNR1	0.0045
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0045
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0045
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0044
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0044
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0044
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0044
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0044
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0044
6211	Tubulin epsilon chain	TUBE1	0.0044
6212	Tubulin gamma-1 chain	TUBG1	0.0044
6210	Tubulin delta chain	TUBD1	0.0044
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0044
2472	Voltage-gated potassium channel	kcsA	0.0043
6366	Voltage-gated potassium channel	kcsA	0.0043
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0043
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0043
1618	High affinity nerve growth factor receptor	NTRK1	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
6432	Transporter	snf	0.0043
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0043
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0042
373	Transthyretin	TTR	0.0042
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0042
3932	Glutathione S-transferase A2	GSTA2	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0041
6014	Cytochrome P450 2A13	CYP2A13	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0041
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.004
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.004
828	Phenylalanine-4-hydroxylase	PAH	0.004
3109	Phenylalanine-4-hydroxylase	phhA	0.004
6085	Fatty acid-binding protein, intestinal	FABP2	0.0039
319	Opioid receptor, sigma 1	OPRS1	0.0039
6146	High affinity copper uptake protein 1	SLC31A1	0.0039
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
284	DNA-directed RNA polymerase beta chain	rpoB	0.0037
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0037
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0037
6163	Copper-transporting ATPase 2	ATP7B	0.0037
6165	Copper-transporting ATPase 1	ATP7A	0.0037
896	Glutathione S-transferase Mu 1	GSTM1	0.0037
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0037
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0037
527	Prostacyclin receptor	PTGIR	0.0036
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0036
2112	Toll-like receptor 9	TLR9	0.0036
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0036
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0036
469	Annexin A1	ANXA1	0.0036
5923	Microtubule-associated protein tau	MAPT	0.0036
5924	Microtubule-associated protein 4	MAP4	0.0036
856	Vitamin D3 receptor	VDR	0.0035
702	UMP-CMP kinase	CMPK1	0.0035
672	Prostaglandin F2-alpha receptor	PTGFR	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
273	Apoptosis regulator Bcl-2	BCL2	0.0035
5126	Arginase	rocF	0.0035
939	50S ribosomal protein L3	rplC	0.0035
295	Carbonic anhydrase 1	CA1	0.0035
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0035
1483	Membrane copper amine oxidase	AOC3	0.0035
4217	Telomerase reverse transcriptase	TERT	0.0035
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0034
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0034
1178	Adenosine A2a receptor	ADORA2A	0.0034
1864	RET proto-oncogene	RET	0.0033
6824	Tyrosine-protein kinase Lyn	LYN	0.0033
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0033
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0033
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0033
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
823	Fibroblast growth factor receptor 2	FGFR2	0.0033
6174	50S ribosomal protein L32	rpmF	0.0032
6167	Organic solute transporter subunit beta	OSTB	0.0032
6166	Organic solute transporter subunit alpha	OSTA	0.0032
6149	Solute carrier family 22 member 10	SLC22A10	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0032
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0032
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0032
3086	Plasmepsin-2	Not Available	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0031
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0031
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0031
6111	DNA polymerase epsilon subunit 4	POLE4	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0031
6112	DNA polymerase epsilon subunit 3	POLE3	0.0031
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0031
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0031
6110	DNA polymerase epsilon subunit 2	POLE2	0.0031
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0031
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0031
6102	Arylamine N-acetyltransferase 2	NAT2	0.0031
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2300	Lysozyme	E	0.003
3633	Lysozyme	R	0.003
5597	Lysozyme	17	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
342	P protein [Includes: DNA-directed DNA polymerase	P	0.003
612	P protein [Includes: DNA-directed DNA polymerase	P	0.003
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.003
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.003
6171	Solute carrier family 28 member 3	SLC28A3	0.003
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.003
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.003
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.003
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0029
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0029
94	5-hydroxytryptamine 4 receptor	HTR4	0.0029
1525	Heparin-binding growth factor 2	FGF2	0.0028
3856	Fibroblast growth factor receptor 3	FGFR3	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0028
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0028
275	Arachidonate 5-lipoxygenase	ALOX5	0.0028
4103	Proteasome subunit beta type 2	PSMB2	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
24	Thymidylate synthase	TMP1	0.0027
359	Thymidylate synthase	TYMS	0.0027
2626	Thymidylate synthase	thyA	0.0027
2729	Thymidylate synthase	thyA	0.0027
5352	Thymidylate synthase	THYA	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0027
780	Retinoic acid receptor RXR-gamma	RXRG	0.0027
2320	Thymidine kinase, cytosolic	TK1	0.0026
3810	Catechol O-methyltransferase	COMT	0.0026
5787	Angiopoietin-1 receptor	TEK	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
5626	Nucleoside diphosphate kinase B	NME2	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
49	Endothelin B receptor	EDNRB	0.0026
33	Cystine/glutamate transporter	SLC7A11	0.0026
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
16	Adenosine A1 receptor	ADORA1	0.0025
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0025
4122	Histone deacetylase 2	HDAC2	0.0025
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
88	Retinoic acid receptor RXR-beta	RXRB	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
357	Carbonic anhydrase 2	CA2	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
365	Dihydrofolate reductase	DHFR	0.0024
2381	Dihydrofolate reductase	DFR1	0.0024
2833	Dihydrofolate reductase	Not Available	0.0024
2931	Dihydrofolate reductase	folA	0.0024
3544	Dihydrofolate reductase	folA	0.0024
3682	Dihydrofolate reductase	folA	0.0024
6642	Dihydrofolate reductase	folA	0.0024
6756	Dihydrofolate reductase	dfrA	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0024
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
603	DNA polymerase alpha catalytic subunit	POLA1	0.0024
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0023
936	Ephrin type-A receptor 2	EPHA2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
6218	Pannexin-1	PANX1	0.0023
5816	Cadherin-5	CDH5	0.0023
751	Potassium channel subfamily K member 6	KCNK6	0.0023
84	Nuclear receptor 0B1	NR0B1	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0022
1196	Complement decay-accelerating factor	CD55	0.0022
1050	Bile salt sulfotransferase	SULT2A1	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
1630	Integrin beta-2	ITGB2	0.0021
172	Potassium channel subfamily K member 1	KCNK1	0.0021
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0021
5294	Nucleoside diphosphate kinase A	NME1	0.0021
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0021
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
3809	Estrogen-related receptor gamma	ESRRG	0.002
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.002
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.002
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.002
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0019
3926	Choline transporter-like protein 2	SLC44A2	0.0019
3925	Choline transporter-like protein 4	SLC44A4	0.0019
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0019
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0019
3927	Choline transporter-like protein 3	SLC44A3	0.0019
1686	Choline transporter-like protein 1	SLC44A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
861	Choline kinase alpha	CHKA	0.0019
769	High-affinity choline transporter 1	SLC5A7	0.0019
700	Choline dehydrogenase, mitochondrial	CHDH	0.0019
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0019
576	Choline O-acetyltransferase	CHAT	0.0019
3922	Phospholipase D2	PLD2	0.0019
3924	Phospholipase D1	PLD1	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
5682	Ribonuclease pancreatic	RNASE1	0.0019
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
1074	Urokinase-type plasminogen activator	PLAU	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0019
2808	Chloramphenicol acetyltransferase 3	cat3	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0019
174	Sigma 1-type opioid receptor	SIGMAR1	0.0019
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0018
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
6048	Troponin C, skeletal muscle	TNNC2	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0018
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0018
277	Purine nucleoside phosphorylase	PNP	0.0018
2870	Purine nucleoside phosphorylase	punA	0.0018
2945	Purine nucleoside phosphorylase	punA	0.0018
4659	Purine nucleoside phosphorylase	TM_1596	0.0018
4825	Purine nucleoside phosphorylase	TTHA1435	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
6044	Serum paraoxonase/lactonase 3	PON3	0.0017
3601	Dihydropteroate synthase 1	folP1	0.0017
3807	Dihydropteroate synthase 1	folP1	0.0017
3808	Dihydropteroate synthase 2	folP2	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
921	Glutamate receptor 2	GRIA2	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
572	Integrin alpha-L	ITGAL	0.0016
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0016
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0016
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0016
1650	Heme carrier protein 1	SLC46A1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0015
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0015
6755	Poliovirus receptor	PVR	0.0015
162	Retinoic acid receptor gamma-1	RARG	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1541	Metalloproteinase	mmp20	0.0014
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0014
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
5934	Cytochrome P450 26A1	CYP26A1	0.0014
183	Vascular endothelial growth factor A	VEGFA	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
3904	Alanine aminotransferase 2	GPT2	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0013
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0012
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
719	Retinoic acid receptor responder protein 1	RARRES1	0.0012
770	Retinoic acid-induced protein 3	GPRC5A	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0012
3957	Adenosine deaminase	ADA	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
6859	Protein S100-A4	S100A4	0.0012
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
6459	Glycodelin	PAEP	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
569	Retinal dehydrogenase 2	ALDH1A2	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
267	Plasminogen activator inhibitor 1	SERPINE1	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
611	Retinal dehydrogenase 1	ALDH1A1	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
6221	Steroid hormone receptor ERR1	ESRRA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0009
1039	Histone deacetylase 9	HDAC9	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
291	Nitric-oxide synthase, endothelial	NOS3	0.0008
760	Fibroblast growth factor 1	FGF1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
2207	Rhodopsin	RHO	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
3937	Fatty-acid amide hydrolase	FAAH	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
563	Thyroid peroxidase	TPO	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2021	Thrombomodulin	THBD	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
517	Alcohol dehydrogenase 1C	ADH1C	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
1992	Vitamin D-binding protein	GC	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01103 - Quinacrine

Targets

Enzymes

Transporters

Predictions