DT-Web

DB00148 - Creatine


Identification
Name Creatine
Accession Number DB00148 (NUTR00022)
Type small molecule
Description An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 131.1332
Groups approved
Monoisotopic Weight 131.069476547
Pharmacology
Indication For nutritional supplementation, also for treating dietary shortage or imbalance
Mechanism of action In the muscles, a fraction of the total creatine binds to phosphate - forming creatine phosphate. The reaction is catalysed by creatine kinase, and the result is phosphocreatine (PCr). Phosphocreatine binds with adenosine diphosphate to convert it back to ATP (adenosine triphosphate), an important cellular energy source for short term ATP needs prior to oxidative phosphorylation.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Creatine kinase M-type
Name Creatine kinase M-type
Gene Name CKM
Pharmacological action yes
Actions ligand
References
  • Zeng L, Hu Q, Wang X, Mansoor A, Lee J, Feygin J, Zhang G, Suntharalingam P, Boozer S, Mhashilkar A, Panetta CJ, Swingen C, Deans R, From AH, Bache RJ, Verfaillie CM, Zhang J: Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling. Circulation. 2007 Apr 10;115(14):1866-75. Epub 2007 Mar 26. - Pubmed
  • Zhou DQ, Hu Y, Liu G, Gong L, Xi Y, Wen L: Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme. Br J Sports Med. 2006 Dec;40(12):988-91. Epub 2006 Sep 25. - Pubmed
  • Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM: Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochem J. 1992 Jan 1;281 ( Pt 1):21-40. - Pubmed
DTHybrid score 1.7417
Creatine kinase, ubiquitous mitochondrial
Name Creatine kinase, ubiquitous mitochondrial
Gene Name CKMT1A
Pharmacological action yes
Actions ligand
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Slenzka K, Appel R, Kappel T, Rahmann H: Influence of altered gravity on brain cellular energy and plasma membrane metabolism of developing lower aquatic vertebrates. Adv Space Res. 1996;17(6-7):125-8. - Pubmed
  • Wyss M, Schlegel J, James P, Eppenberger HM, Wallimann T: Mitochondrial creatine kinase from chicken brain. Purification, biophysical characterization, and generation of heterodimeric and heterooctameric molecules with subunits of other creatine kinase isoenzymes. J Biol Chem. 1990 Sep 15;265(26):15900-8. - Pubmed
  • Muhlebach SM, Wirz T, Brandle U, Perriard JC: Evolution of the creative kinases. The chicken acidic type mitochondrial creatine kinase gene as the first nonmammalian gene. J Biol Chem. 1996 May 17;271(20):11920-9. - Pubmed
  • Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM: Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochem J. 1992 Jan 1;281 ( Pt 1):21-40. - Pubmed
DTHybrid score 1.1949
Creatine kinase B-type
Name Creatine kinase B-type
Gene Name CKB
Pharmacological action yes
Actions ligand
References
  • Tian XF, Zhang XS, Li YH, Wang ZZ, Zhang F, Wang LM, Yao JH: Proteasome inhibition attenuates lung injury induced by intestinal ischemia reperfusion in rats. Life Sci. 2006 Oct 26;79(22):2069-76. Epub 2006 Jun 23. - Pubmed
  • Debrincat MA, Zhang JG, Willson TA, Silke J, Connolly LM, Simpson RJ, Alexander WS, Nicola NA, Kile BT, Hilton DJ: Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. J Biol Chem. 2007 Feb 16;282(7):4728-37. Epub 2006 Dec 5. - Pubmed
  • Burklen TS, Hirschy A, Wallimann T: Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase. Mol Cell Biochem. 2007 Mar;297(1-2):53-64. Epub 2006 Oct 12. - Pubmed
  • Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM: Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochem J. 1992 Jan 1;281 ( Pt 1):21-40. - Pubmed
DTHybrid score 1.1833
Creatine kinase, sarcomeric mitochondrial
Name Creatine kinase, sarcomeric mitochondrial
Gene Name CKMT2
Pharmacological action yes
Actions ligand
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Koufen P, Ruck A, Brdiczka D, Wendt S, Wallimann T, Stark G: Free radical-induced inactivation of creatine kinase: influence on the octameric and dimeric states of the mitochondrial enzyme (Mib-CK). Biochem J. 1999 Dec 1;344 Pt 2:413-7. - Pubmed
  • Wyss M, James P, Schlegel J, Wallimann T: Limited proteolysis of creatine kinase. Implications for three-dimensional structure and for conformational substrates. Biochemistry. 1993 Oct 12;32(40):10727-35. - Pubmed
  • Stachowiak O, Dolder M, Wallimann T, Richter C: Mitochondrial creatine kinase is a prime target of peroxynitrite-induced modification and inactivation. J Biol Chem. 1998 Jul 3;273(27):16694-9. - Pubmed
  • Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM: Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochem J. 1992 Jan 1;281 ( Pt 1):21-40. - Pubmed
DTHybrid score 1.1918
Sodium- and chloride-dependent creatine transporter 1
Name Sodium- and chloride-dependent creatine transporter 1
Gene Name SLC6A8
Pharmacological action yes
Actions Not Available
References
  • Rosenberg EH, Munoz CM, Degrauw TJ, Jakobs C, Salomons GS: Overexpression of wild-type creatine transporter (SLC6A8) restores creatine uptake in primary SLC6A8-deficient fibroblasts. J Inherit Metab Dis. 2006 Apr-Jun;29(2-3):345-6. - Pubmed
  • Derave W, Straumann N, Olek RA, Hespel P: Electrolysis stimulates creatine transport and transporter cell surface expression in incubated mouse skeletal muscle: potential role of ROS. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1250-7. Epub 2006 Jul 18. - Pubmed
  • Lunardi G, Parodi A, Perasso L, Pohvozcheva AV, Scarrone S, Adriano E, Florio T, Gandolfo C, Cupello A, Burov SV, Balestrino M: The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds. Neuroscience. 2006 Nov 3;142(4):991-7. Epub 2006 Sep 1. - Pubmed
  • Campistol J, Arias-Dimas A, Poo P, Pineda M, Hoffman M, Vilaseca MA, Artuch R, Ribes A: [Cerebral creatine transporter deficiency: an infradiagnosed neurometabolic disease] Rev Neurol. 2007 Mar 16-31;44(6):343-7. - Pubmed
  • Wang L, Zhang Y, Shao M, Zhang H: Spatiotemporal expression of the creatine metabolism related genes agat, gamt and ct1 during zebrafish embryogenesis. Int J Dev Biol. 2007;51(3):247-53. - Pubmed
DTHybrid score 1.1576
Guanidinoacetate N-methyltransferase
Name Guanidinoacetate N-methyltransferase
Gene Name GAMT
Pharmacological action yes
Actions product of
References
  • Almeida LS, Vilarinho L, Darmin PS, Rosenberg EH, Martinez-Munoz C, Jakobs C, Salomons GS: A prevalent pathogenic GAMT mutation (c.59G>C) in Portugal. Mol Genet Metab. 2007 May;91(1):1-6. Epub 2007 Mar 1. - Pubmed
  • Kan HE, Meeuwissen E, van Asten JJ, Veltien A, Isbrandt D, Heerschap A: Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy. J Appl Physiol. 2007 Jun;102(6):2121-7. Epub 2007 Mar 8. - Pubmed
  • Wang L, Zhang Y, Shao M, Zhang H: Spatiotemporal expression of the creatine metabolism related genes agat, gamt and ct1 during zebrafish embryogenesis. Int J Dev Biol. 2007;51(3):247-53. - Pubmed
DTHybrid score 1.2111

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score 0.5177

Predictions


Id Partner name Gene Name Score
833 Organic cation/carnitine transporter 1 SLC22A4 0.0588
6145 Solute carrier family 22 member 1 SLC22A1 0.0434
6144 Solute carrier family 22 member 2 SLC22A2 0.04
5126 Arginase rocF 0.0397
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0376
6147 Solute carrier family 22 member 3 SLC22A3 0.037
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0361
6142 Solute carrier family 22 member 8 SLC22A8 0.0348
4119 Cytochrome P450 2D6 CYP2D6 0.0274
1729 Solute carrier family 22 member 6 SLC22A6 0.0247
5682 Ribonuclease pancreatic RNASE1 0.0237
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0236
2300 Lysozyme E 0.0209
3633 Lysozyme R 0.0209
5597 Lysozyme 17 0.0209
477 DNA topoisomerase 4 subunit A parC 0.0178
886 DNA topoisomerase 4 subunit A parC 0.0178
6226 DNA topoisomerase 4 subunit A parC 0.0178
4200 Cytochrome P450 1A2 CYP1A2 0.0177
404 DNA gyrase subunit A gyrA 0.0175
6224 DNA gyrase subunit A gyrA 0.0175
4512 Cytochrome P450 3A4 CYP3A4 0.0172
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0154
1588 Multidrug resistance protein 1 ABCB1 0.0153
159 Penicillin-binding protein 2B penA 0.0153
6121 Penicillin-binding protein 2B penA 0.0153
1998 Protein-L-isoaspartate(D-aspartate) O-methyltransferase PCMT1 0.0142
4330 Hypothetical protein TTHA0667 TTHA0667 0.0142
4333 Protein-L-isoaspartate O-methyltransferase pcm 0.0142
2551 Cobalt-precorrin-4 C(11)-methyltransferase cbiF 0.0142
4313 Probable tRNA/rRNA methyltransferase HI0766 trmL 0.0142
4331 Chemotaxis protein methyltransferase cheR 0.0142
4309 S-adenosyl-L-methionine-dependent methyltransferase mraW rsmH 0.0142
4314 Modification methylase PvuII pvuIIM 0.0142
4324 Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 SETD7 0.0142
4315 DNA adenine methylase DAM 0.0142
3724 Protein methyltransferase hemK hemK 0.0142
4329 Uroporphyrinogen-III C-methyltransferase cobA 0.0142
4316 Mycolic acid synthase pcaA 0.0142
4323 Modification methylase HhaI hhaIM 0.0142
817 DNA topoisomerase 2-alpha TOP2A 0.0131
1024 Solute carrier family 22 member 11 SLC22A11 0.0128
4306 HemK protein TM_0488 0.0125
4332 Modification methylase TaqI taqIM 0.0124
4318 Siroheme synthase cysG 0.0124
4310 rRNA adenine N-6-methyltransferase ermC' 0.0123
3117 Carminomycin 4-O-methyltransferase dnrK 0.0123
4302 METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 mmaA2 0.0122
2242 Cyclopropane-fatty-acyl-phospholipid synthase 2 cmaA2 0.0122
2297 Genome polyprotein Not Available 0.0122
2322 Genome polyprotein Not Available 0.0122
2694 Genome polyprotein Not Available 0.0122
2719 Genome polyprotein Not Available 0.0122
2860 Genome polyprotein Not Available 0.0122
2928 Genome polyprotein Not Available 0.0122
3160 Genome polyprotein Not Available 0.0122
3260 Genome polyprotein Not Available 0.0122
4783 Genome polyprotein Not Available 0.0122
5726 Genome polyprotein Not Available 0.0122
5779 Genome polyprotein Not Available 0.0122
5867 Genome polyprotein Not Available 0.0122
6253 Genome polyprotein Not Available 0.0122
6301 Genome polyprotein Not Available 0.0122
6380 Genome polyprotein Not Available 0.0122
6381 Genome polyprotein Not Available 0.0122
6437 Genome polyprotein Not Available 0.0122
6520 Genome polyprotein Not Available 0.0122
6521 Genome polyprotein Not Available 0.0122
6652 Genome polyprotein Not Available 0.0122
6734 Genome polyprotein Not Available 0.0122
6735 Genome polyprotein Not Available 0.0122
6736 Genome polyprotein Not Available 0.0122
6737 Genome polyprotein Not Available 0.0122
6738 Genome polyprotein Not Available 0.0122
6739 Genome polyprotein Not Available 0.0122
6744 Genome polyprotein Not Available 0.0122
6748 Genome polyprotein Not Available 0.0122
6894 Genome polyprotein Not Available 0.0122
6898 Genome polyprotein Not Available 0.0122
4327 RdmB rdmB 0.0113
2653 Modification methylase RsrI rsrIM 0.0113
862 Multidrug resistance-associated protein 1 ABCC1 0.0109
4203 Histamine N-methyltransferase HNMT 0.0108
4311 tRNA TRDMT1 0.0104
4325 tRNA trmD 0.0104
4328 tRNA trmD 0.0104
633 Penicillin-binding proteins 1A/1B pbpA 0.0104
411 Glycine N-methyltransferase GNMT 0.0101
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
4757 Cytochrome P450 2C9 CYP2C9 0.0094
738 Monocarboxylate transporter 1 SLC16A1 0.0093
2557 Cap-specific mRNA PAPS 0.0092
6010 Thiamine transporter 1 SLC19A2 0.0089
492 Histamine H1 receptor HRH1 0.0088
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
974 Phenylethanolamine N-methyltransferase PNMT 0.0082
175 Thiamin pyrophosphokinase 1 TPK1 0.008
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
5718 Cytochrome P450 2A6 CYP2A6 0.0075
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
645 Penicillin-binding protein 1A mrcA 0.0073
5805 Penicillin-binding protein 1A ponA 0.0073
6185 Penicillin-binding protein 1A mrcA 0.0073
6799 Penicillin-binding protein 1A pbpA 0.0073
587 Serum albumin ALB 0.0072
6137 Multidrug resistance-associated protein 6 ABCC6 0.0066
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0065
629 Alpha-2B adrenergic receptor ADRA2B 0.0065
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0064
6016 Cytochrome P450 2C19 CYP2C19 0.0064
4118 Cytochrome P450 3A5 CYP3A5 0.0064
474 Acetylcholinesterase ACHE 0.0063
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0062
1757 Myeloperoxidase MPO 0.0061
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.006
6106 Cytochrome P450 2C18 CYP2C18 0.006
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
713 Sodium-dependent dopamine transporter SLC6A3 0.0059
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0059
318 Alpha-2A adrenergic receptor ADRA2A 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
6030 Cytochrome P450 2B6 CYP2B6 0.0057
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0056
6143 Solute carrier family 22 member 7 SLC22A7 0.0055
6024 Cytochrome P450 1A1 CYP1A1 0.0055
6107 Cytochrome P450 3A7 CYP3A7 0.0055
4924 Cytochrome P450 2C8 CYP2C8 0.0054
5288 Shikimate kinase aroK 0.0053
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0053
5293 Shikimate kinase 2 aroL 0.0053
5304 UPF0166 protein TM_0021 TM_0021 0.0053
5287 Signaling protein Not Available 0.0053
5292 Putative partitioning protein TT_C1605 0.0053
5266 Activator of hgdC 0.0053
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0053
3199 Phosphopantetheine adenylyltransferase coaD 0.0053
3543 Phosphopantetheine adenylyltransferase coaD 0.0053
3567 Phosphopantetheine adenylyltransferase coaD 0.0053
5289 Phosphopantetheine adenylyltransferase coaD 0.0053
2874 Nitrogenase iron protein 1 nifH1 0.0053
4346 Polynucleotide kinase pseT 0.0053
5283 D-alanine--D-alanine ligase B ddlB 0.0053
5291 Glycogen synthase 1 glgA1 0.0053
5281 Plasmid segregation protein parM parM 0.0053
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0053
5299 D-alanine--D-alanine ligase ddl 0.0053
6598 D-alanine--D-alanine ligase ddl 0.0053
5276 Chromosomal replication initiator protein dnaA dnaA 0.0053
5259 Transcriptional regulator ntrC1 0.0053
6699 Transcriptional regulator Cgl2612 0.0053
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0053
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0053
5264 DNA replication protein REP 0.0053
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0053
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0053
5315 Chaperone protein htpG htpG 0.0053
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0053
5284 Large T antigen Not Available 0.0053
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0053
5277 Preprotein translocase subunit secA secA 0.0053
5308 Preprotein translocase secA 1 subunit secA1 0.0053
5285 Kinesin heavy chain KIF5B 0.0053
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0053
5261 Phosphoribosylformylglycinamidine synthase purL 0.0053
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
378 Alpha-2C adrenergic receptor ADRA2C 0.0049
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0048
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0046
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0046
3426 Glutamine synthetase glnA 0.0044
3987 Glutamine synthetase GLUL 0.0044
3175 Glutamate--cysteine ligase gshA 0.0044
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0044
3470 Hypothetical protein MG245 homolog MPN_348 0.0044
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0044
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0044
2270 Dephospho-CoA kinase coaE 0.0044
4837 Cag-alfa cag-alfa 0.0044
4774 NTPase P4 Not Available 0.0044
4106 Guanylate kinase GUK1 0.0044
4516 Guanylate kinase gmk 0.0044
2284 Adenylate kinase adk 0.0044
2296 Adenylate kinase adk 0.0044
2311 Adenylate kinase adk 0.0044
2312 Adenylate kinase Not Available 0.0044
5646 Galactokinase GALK1 0.0044
413 Amidophosphoribosyltransferase PPAT 0.0044
2515 Amidophosphoribosyltransferase purF 0.0044
3714 Amidophosphoribosyltransferase purF 0.0044
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0044
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0044
5265 FtsH ftsH 0.0044
4839 DNA polymerase III subunit tau dnaX 0.0044
5302 TrwB trwB 0.0044
6277 Heat shock cognate 71 kDa protein HSPA8 0.0044
5189 Trimethylamine dehydrogenase tmd 0.0044
4838 PMS1 protein homolog 2 PMS2 0.0044
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
380 Cytochrome P450 17A1 CYP17A1 0.0042
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0042
2683 Mono-ADP-ribosyltransferase C3 C3 0.0041
2390 Nonsecretory ribonuclease RNASE2 0.004
2922 Glycerol kinase glpK 0.004
5271 Focal adhesion kinase 1 PTK2 0.004
5312 Kinesin-like protein KIF1A KIF1A 0.004
5300 Antigen peptide transporter 1 TAP1 0.0039
340 Apoptotic protease-activating factor 1 APAF1 0.0039
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0038
3941 Amine oxidase [flavin-containing] A MAOA 0.0038
3939 Amine oxidase [flavin-containing] B MAOB 0.0037
2892 Acetylglutamate kinase argB 0.0037
3550 Acetylglutamate kinase argB 0.0037
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
2371 Pantothenate kinase coaA 0.0037
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0037
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0037
1881 Hexokinase-1 HK1 0.0037
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0037
3669 Ribokinase rbsK 0.0037
825 Arsenical pump-driving ATPase ASNA1 0.0037
3435 Arsenical pump-driving ATPase arsA 0.0037
2615 Chemotaxis protein cheA cheA 0.0037
408 Riboflavin kinase RFK 0.0037
2282 Protein recA recA 0.0037
2315 Protein recA recA 0.0037
2332 Protein recA recA 0.0037
5263 Protein recA recA 0.0037
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0037
193 Beta-1 adrenergic receptor ADRB1 0.0036
6013 Cytochrome P450 2E1 CYP2E1 0.0036
766 Beta-2 adrenergic receptor ADRB2 0.0035
2727 S-adenosylmethionine synthetase metK 0.0035
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0035
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0035
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0035
2334 Dethiobiotin synthetase bioD 0.0034
6555 Dethiobiotin synthetase bioD 0.0034
1341 Histamine H3 receptor HRH3 0.0034
124 Histamine H2 receptor HRH2 0.0034
2697 Uridine-cytidine kinase 2 UCK2 0.0034
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0034
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0034
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0033
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0033
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0033
499 Arginine decarboxylase ADC 0.0033
164 Histamine H4 receptor HRH4 0.0032
207 Glutathione synthetase GSS 0.0032
5269 Glutathione synthetase gshB 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0032
556 Alpha-1A adrenergic receptor ADRA1A 0.0032
3923 Cholinesterase BCHE 0.0031
48 Pyridoxal kinase PDXK 0.0031
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0031
789 Alpha-1D adrenergic receptor ADRA1D 0.0031
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0031
6395 Myosin-14 MYH14 0.0031
2091 Endoplasmin HSP90B1 0.0031
577 Argininosuccinate lyase ASL 0.0031
702 UMP-CMP kinase CMPK1 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
2251 Thymidylate kinase tmk 0.003
2254 Thymidylate kinase DTYMK 0.003
3522 Thymidylate kinase tmk 0.003
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
1422 Serine/threonine-protein kinase 6 AURKA 0.003
824 Sodium-dependent serotonin transporter SLC6A4 0.003
3379 Kinesin-like protein KIF11 KIF11 0.0029
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0028
3822 Actin, alpha skeletal muscle ACTA1 0.0028
632 Alpha-1B adrenergic receptor ADRA1B 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
504 Mast/stem cell growth factor receptor KIT 0.0028
6168 Solute carrier family 22 member 16 SLC22A16 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
558 Solute carrier family 12 member 1 SLC12A1 0.0027
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0027
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0027
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
509 Thymidine kinase TK 0.0027
570 Thymidine kinase TK 0.0027
2559 Thymidine kinase TK 0.0027
3430 Thymidine kinase tdk 0.0027
3518 Thymidine kinase TK 0.0027
5301 Thymidine kinase tdk 0.0027
5771 Thymidine kinase ORF36 0.0027
7009 Thymidine kinase ORF36 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
5294 Nucleoside diphosphate kinase A NME1 0.0026
1721 Glycogen synthase kinase-3 beta GSK3B 0.0026
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0026
976 Platelet glycoprotein IX GP9 0.0025
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0025
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0025
20 Prostaglandin G/H synthase 1 PTGS1 0.0024
776 Bile salt export pump ABCB11 0.0023
4773 Deoxycytidine kinase DCK 0.0023
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0022
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
844 Epidermal growth factor receptor EGFR 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
7 Nitric oxide synthase, inducible NOS2 0.0019
357 Carbonic anhydrase 2 CA2 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
6151 Monocarboxylate transporter 10 SLC16A10 0.0019
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
4604 Liver carboxylesterase 1 CES1 0.0018
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0017
6218 Pannexin-1 PANX1 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
751 Potassium channel subfamily K member 6 KCNK6 0.0017
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0017
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
172 Potassium channel subfamily K member 1 KCNK1 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0015
3810 Catechol O-methyltransferase COMT 0.0014
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
2164 Multidrug resistance-associated protein 4 ABCC4 0.0013
163 D(1B) dopamine receptor DRD5 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
432 D(4) dopamine receptor DRD4 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
638 D(3) dopamine receptor DRD3 0.0012
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0012
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0012
6014 Cytochrome P450 2A13 CYP2A13 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0012
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
6432 Transporter snf 0.0011
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0011
23 D(1A) dopamine receptor DRD1 0.0011
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
831 D(2) dopamine receptor DRD2 0.001
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.001
6141 Sodium/bile acid cotransporter SLC10A1 0.001
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0009
6136 Multidrug resistance-associated protein 5 ABCC5 0.0009
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0009
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0009
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0009
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0008
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0008
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0008
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0008
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0008
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0007
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0007
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0007
502 5-hydroxytryptamine 2A receptor HTR2A 0.0007
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0007
6148 Multidrug resistance-associated protein 7 ABCC10 0.0007
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