DT-Web

DB01181 - Ifosfamide


Identification
Name Ifosfamide
Accession Number DB01181 (APRD00007)
Type small molecule
Description Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppresive agent.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 261.086
Groups approved
Monoisotopic Weight 260.02481966
Pharmacology
Indication Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma.
Mechanism of action The exact mechanism of ifosfamide has not been determined, but appears to be similar to other alkylating agents. Ifosfamide requires biotransformation in the liver by mixed-function oxidases (cytochrome P450 system) before it becomes active. After metabolic activation, active metabolites of ifosfamide alkylate or bind with many intracellular molecular structures, including nucleic acids. The cytotoxic action is primarily through the alkylation of DNA, done by attaching the N-7 position of guanine to its reactive electrophilic groups. The formation of inter and intra strand cross-links in the DNA results in cell death.
Absorption Not Available
Protein binding Ifosfamide shows little plasma protein binding.
Biotransformation Primarily hepatic. Ifosfamide is metabolized through two metabolic pathways: ring oxidation ("activation") to form the active metabolite, 4-hydroxy-ifosfamide and side-chain oxidation to form the inactive metabolites, 3-dechloro-ethylifosfamide or 2-dechloroethylifosfamide with liberation of the toxic metabolite, chloroacetaldehyde. Small quantities (nmol/mL) of ifosfamide mustard and 4-hydroxyifosfamide are detectable in human plasma. Metabolism of ifosfamide is required for the generation of the biologically active species and while metabolism is extensive, it is also quite variable among patients.
Route of elimination Ifosfamide is extensively metabolized in humans and the metabolic pathways appear to be saturated at high doses. After administration of doses of 5 g/m2 of 14C-labeled ifosfamide, from 70% to 86% of the dosed radioactivity was recovered in the urine, with about 61% of the dose excreted as parent compound. At doses of 1.6-2.4 g/m2 only 12% to 18% of the dose was excreted in the urine as unchanged drug within 72 hours.
Toxicity LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Aprepitant Aprepitant may change levels of the chemotherapy agent, ifosfamide.
Bendamustine Increases toxicity through pharmacodynamic synergism. Additive myelosuppression.
Etravirine Ifosfamide, when administered concomitantly with etravirine (a strong CYP3A4 inducer), may experience an increase in the serum concentrations of its active metabolites. It is recommended to monitor for toxicity of ifosfamide therapy.
Pazopanib Ifosfamide decreases plasma levels of pazopanib.
Telithromycin Telithromycin may reduce clearance of Ifosfamide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ifosfamide if Telithromycin is initiated, discontinued or dose changed.
Ticlopidine Ticlopidine may decrease the metabolism and clearance of Ifosfamide. Consider alternate therapy or monitor for adverse/toxic effects of Ifosfamide if Ticlopidine is initiated, discontinued or dose changed.
Tranylcypromine Tranylcypromine, a strong CYP2A6 inhibitor, may decrease the metabolism and clearance of Ifosmadine.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of ifosfamide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of ifosfamide if voriconazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions other/unknown
References
  • Furlanut M, Franceschi L: Pharmacology of ifosfamide. Oncology. 2003;65 Suppl 2:2-6. - Pubmed
  • Hartley JM, Spanswick VJ, Gander M, Giacomini G, Whelan J, Souhami RL, Hartley JA: Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay. Clin Cancer Res. 1999 Mar;5(3):507-12. - Pubmed
  • Willits I, Price L, Parry A, Tilby MJ, Ford D, Cholerton S, Pearson AD, Boddy AV: Pharmacokinetics and metabolism of ifosfamide in relation to DNA damage assessed by the COMET assay in children with cancer. Br J Cancer. 2005 May 9;92(9):1626-35. - Pubmed
  • Lokiec F: Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention. Ann Oncol. 2006 May;17 Suppl 4:iv33-6. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Lokiec F: Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention. Ann Oncol. 2006 May;17 Suppl 4:iv33-6. - Pubmed
  • Chen CS, Jounaidi Y, Waxman DJ: Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450. Drug Metab Dispos. 2005 Sep;33(9):1261-7. Epub 2005 May 26. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Roy P, Yu LJ, Crespi CL, Waxman DJ: Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. - Pubmed
DTHybrid score 0.4014
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Lokiec F: Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention. Ann Oncol. 2006 May;17 Suppl 4:iv33-6. - Pubmed
  • Chen CS, Jounaidi Y, Waxman DJ: Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450. Drug Metab Dispos. 2005 Sep;33(9):1261-7. Epub 2005 May 26. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Roy P, Yu LJ, Crespi CL, Waxman DJ: Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. - Pubmed
  • Preiss R, Schmidt R, Baumann F, Hanschmann H, Hauss J, Geissler F, Pahlig H, Ratzewiss B: Measurement of 4-hydroxylation of ifosfamide in human liver microsomes using the estimation of free and protein-bound acrolein and codetermination of keto- and carboxyifosfamide. J Cancer Res Clin Oncol. 2002 Jul;128(7):385-92. Epub 2002 Jun 11. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.81
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Lokiec F: Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention. Ann Oncol. 2006 May;17 Suppl 4:iv33-6. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Roy P, Yu LJ, Crespi CL, Waxman DJ: Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. - Pubmed
DTHybrid score 0.4593
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Roy P, Yu LJ, Crespi CL, Waxman DJ: Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5502
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inducer
References
  • Lokiec F: Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention. Ann Oncol. 2006 May;17 Suppl 4:iv33-6. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6561
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inducer
References
  • Lokiec F: Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention. Ann Oncol. 2006 May;17 Suppl 4:iv33-6. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.477
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Lokiec F: Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention. Ann Oncol. 2006 May;17 Suppl 4:iv33-6. - Pubmed
  • Roy P, Yu LJ, Crespi CL, Waxman DJ: Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3611
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions substrate
References
  • Roy P, Yu LJ, Crespi CL, Waxman DJ: Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2463
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4999
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3658

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.4107
4200 Cytochrome P450 1A2 CYP1A2 0.3483
1588 Multidrug resistance protein 1 ABCB1 0.3229
6013 Cytochrome P450 2E1 CYP2E1 0.2162
290 Prostaglandin G/H synthase 2 PTGS2 0.1917
6024 Cytochrome P450 1A1 CYP1A1 0.1535
587 Serum albumin ALB 0.1379
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1084
1729 Solute carrier family 22 member 6 SLC22A6 0.0874
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0837
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.08
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0713
492 Histamine H1 receptor HRH1 0.0703
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0695
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0665
824 Sodium-dependent serotonin transporter SLC6A4 0.0659
3811 Cytochrome P450 19A1 CYP19A1 0.0651
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0648
862 Multidrug resistance-associated protein 1 ABCC1 0.0638
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0581
1898 Cytochrome P450 1B1 CYP1B1 0.057
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0554
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0518
847 Mu-type opioid receptor OPRM1 0.0508
6145 Solute carrier family 22 member 1 SLC22A1 0.0503
6144 Solute carrier family 22 member 2 SLC22A2 0.0482
6031 Cytochrome P450 3A43 CYP3A43 0.0482
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0468
468 Cytochrome P450 4A11 CYP4A11 0.0467
776 Bile salt export pump ABCB11 0.0453
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0448
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0446
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0442
502 5-hydroxytryptamine 2A receptor HTR2A 0.0432
6142 Solute carrier family 22 member 8 SLC22A8 0.0425
2164 Multidrug resistance-associated protein 4 ABCC4 0.0424
831 D(2) dopamine receptor DRD2 0.0408
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0405
467 Delta-type opioid receptor OPRD1 0.0404
260 Cytochrome P450 51 ERG11 0.0397
761 Cytochrome P450 51 ERG11 0.0397
3163 Cytochrome P450 51 cyp51 0.0397
118 Organic cation/carnitine transporter 2 SLC22A5 0.0392
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.039
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0386
6143 Solute carrier family 22 member 7 SLC22A7 0.0385
320 5-hydroxytryptamine 1A receptor HTR1A 0.038
275 Arachidonate 5-lipoxygenase ALOX5 0.0377
136 Estrogen receptor ESR1 0.0377
871 Glucocorticoid receptor NR3C1 0.0369
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0368
731 HIV-1 protease HIV-1 protease 0.0364
556 Alpha-1A adrenergic receptor ADRA1A 0.0363
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0362
696 Kappa-type opioid receptor OPRK1 0.0359
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0359
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0357
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0346
713 Sodium-dependent dopamine transporter SLC6A3 0.0338
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0335
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0332
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.033
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.033
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0325
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0322
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0305
341 5-hydroxytryptamine 3 receptor HTR3A 0.0305
766 Beta-2 adrenergic receptor ADRB2 0.0305
590 5-hydroxytryptamine 2C receptor HTR2C 0.0295
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0289
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0285
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0283
6147 Solute carrier family 22 member 3 SLC22A3 0.0281
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0279
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0279
465 Calmodulin CALM1 0.0278
811 Translocator protein TSPO 0.0271
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0269
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0262
318 Alpha-2A adrenergic receptor ADRA2A 0.0262
6102 Arylamine N-acetyltransferase 2 NAT2 0.0261
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0259
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0257
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0255
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0252
6182 Cytochrome P450 2J2 CYP2J2 0.0251
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0248
1024 Solute carrier family 22 member 11 SLC22A11 0.0248
23 D(1A) dopamine receptor DRD1 0.0245
891 Dihydropteroate synthase folP 0.0245
5359 Dihydropteroate synthase folP 0.0245
7175 Dihydropteroate synthase sulI 0.0245
122 P2Y purinoceptor 12 P2RY12 0.0244
3941 Amine oxidase [flavin-containing] A MAOA 0.0244
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0243
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0243
1757 Myeloperoxidase MPO 0.0235
146 Androgen receptor AR 0.0232
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.023
632 Alpha-1B adrenergic receptor ADRA1B 0.023
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.023
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0224
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0221
3923 Cholinesterase BCHE 0.0221
6014 Cytochrome P450 2A13 CYP2A13 0.022
614 Progesterone receptor PGR 0.0218
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0216
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0216
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0216
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0214
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0213
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0213
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0213
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0211
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.021
833 Organic cation/carnitine transporter 1 SLC22A4 0.0209
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0209
638 D(3) dopamine receptor DRD3 0.0207
6148 Multidrug resistance-associated protein 7 ABCC10 0.0205
844 Epidermal growth factor receptor EGFR 0.0204
70 Type-1 angiotensin II receptor AGTR1 0.0203
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0201
817 DNA topoisomerase 2-alpha TOP2A 0.02
3939 Amine oxidase [flavin-containing] B MAOB 0.02
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.02
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0196
380 Cytochrome P450 17A1 CYP17A1 0.0196
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0193
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0189
737 Mineralocorticoid receptor NR3C2 0.0187
6136 Multidrug resistance-associated protein 5 ABCC5 0.0187
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0186
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0183
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0181
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0181
504 Mast/stem cell growth factor receptor KIT 0.0178
232 Corticosteroid-binding globulin SERPINA6 0.0176
885 5-hydroxytryptamine 1B receptor HTR1B 0.0176
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0174
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0174
756 Sex hormone-binding globulin SHBG 0.0172
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.017
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0169
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0169
427 Substance-P receptor TACR1 0.0169
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0167
373 Transthyretin TTR 0.0167
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0164
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0163
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0162
4604 Liver carboxylesterase 1 CES1 0.016
789 Alpha-1D adrenergic receptor ADRA1D 0.0159
85 Growth hormone receptor GHR 0.0156
6174 50S ribosomal protein L32 rpmF 0.0155
4120 NADPH--cytochrome P450 reductase POR 0.0155
6137 Multidrug resistance-associated protein 6 ABCC6 0.0154
1010 Cytochrome P450 51A1 CYP51A1 0.0151
705 Glutamate receptor 1 GRIA1 0.0151
725 5-hydroxytryptamine 1D receptor HTR1D 0.0149
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0149
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0147
193 Beta-1 adrenergic receptor ADRB1 0.0146
4148 Serine/threonine-protein kinase mTOR MTOR 0.0145
6141 Sodium/bile acid cotransporter SLC10A1 0.0145
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0145
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0144
738 Monocarboxylate transporter 1 SLC16A1 0.0144
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0144
6220 Aryl hydrocarbon receptor AHR 0.0143
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0143
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0142
716 5-hydroxytryptamine 7 receptor HTR7 0.0142
29 Tubulin beta-1 chain TUBB1 0.0142
818 50S ribosomal protein L10 rplJ 0.0141
94 5-hydroxytryptamine 4 receptor HTR4 0.014
407 Vascular endothelial growth factor receptor 2 KDR 0.014
84 Nuclear receptor 0B1 NR0B1 0.0137
482 Glycine receptor subunit alpha-1 GLRA1 0.0136
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0136
869 Estrogen receptor beta ESR2 0.0135
26 Vascular endothelial growth factor receptor 3 FLT4 0.0135
228 Beta platelet-derived growth factor receptor PDGFRB 0.0134
921 Glutamate receptor 2 GRIA2 0.0132
3808 Dihydropteroate synthase 2 folP2 0.0132
3601 Dihydropteroate synthase 1 folP1 0.0132
3807 Dihydropteroate synthase 1 folP1 0.0132
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0132
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0132
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.013
777 Tumor necrosis factor TNF 0.0129
32 Vascular endothelial growth factor receptor 1 FLT1 0.0128
6085 Fatty acid-binding protein, intestinal FABP2 0.0128
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0126
629 Alpha-2B adrenergic receptor ADRA2B 0.0125
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0125
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0125
4237 50S ribosomal protein L22 rplV 0.0123
378 Alpha-2C adrenergic receptor ADRA2C 0.0123
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0122
6020 Aldehyde oxidase AOX1 0.0122
1507 Cytochrome c CYCS 0.0121
1656 CYP2B protein CYP2B 0.0121
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.012
432 D(4) dopamine receptor DRD4 0.0118
174 Sigma 1-type opioid receptor SIGMAR1 0.0117
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0114
4238 50S ribosomal protein L4 rplD 0.0113
5578 50S ribosomal protein L4 rplD 0.0113
6173 50S ribosomal protein L4 rplD 0.0113
6219 50S ribosomal protein L4 rplD 0.0113
88 Retinoic acid receptor RXR-beta RXRB 0.0111
124 Histamine H2 receptor HRH2 0.0111
68 Cannabinoid receptor 1 CNR1 0.0111
950 Alpha platelet-derived growth factor receptor PDGFRA 0.011
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0109
528 5-hydroxytryptamine 1E receptor HTR1E 0.0109
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0109
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0109
161 Tubulin beta chain TUBB 0.0108
312 Tubulin beta chain TUB2 0.0108
537 ATP synthase delta chain, mitochondrial ATP5D 0.0108
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0108
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0108
295 Carbonic anhydrase 1 CA1 0.0105
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0103
952 Dipeptidyl peptidase 4 DPP4 0.0101
719 Retinoic acid receptor responder protein 1 RARRES1 0.01
770 Retinoic acid-induced protein 3 GPRC5A 0.01
723 Cytosolic phospholipase A2 PLA2G4A 0.01
780 Retinoic acid receptor RXR-gamma RXRG 0.0099
2183 Fatty acid-binding protein, adipocyte FABP4 0.0098
7 Nitric oxide synthase, inducible NOS2 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
208 DNA-directed RNA polymerase beta' chain rpoC 0.0096
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0096
49 Endothelin B receptor EDNRB 0.0096
2539 Tubulin alpha-1 chain TUBA4A 0.0095
3932 Glutathione S-transferase A2 GSTA2 0.0094
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0094
477 DNA topoisomerase 4 subunit A parC 0.0093
886 DNA topoisomerase 4 subunit A parC 0.0093
6226 DNA topoisomerase 4 subunit A parC 0.0093
823 Fibroblast growth factor receptor 2 FGFR2 0.0093
436 5-hydroxytryptamine 2B receptor HTR2B 0.0092
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0092
1050 Bile salt sulfotransferase SULT2A1 0.0092
404 DNA gyrase subunit A gyrA 0.0092
6224 DNA gyrase subunit A gyrA 0.0092
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0092
578 Endothelin-1 receptor EDNRA 0.009
592 Carbonic anhydrase 4 CA4 0.009
1192 Sulfotransferase 1A1 SULT1A1 0.009
469 Annexin A1 ANXA1 0.009
518 Peroxidase/catalase T katG 0.0089
6432 Transporter snf 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
558 Solute carrier family 12 member 1 SLC12A1 0.0088
569 Retinal dehydrogenase 2 ALDH1A2 0.0087
365 Dihydrofolate reductase DHFR 0.0087
2381 Dihydrofolate reductase DFR1 0.0087
2833 Dihydrofolate reductase Not Available 0.0087
2931 Dihydrofolate reductase folA 0.0087
3544 Dihydrofolate reductase folA 0.0087
3682 Dihydrofolate reductase folA 0.0087
6642 Dihydrofolate reductase folA 0.0087
6756 Dihydrofolate reductase dfrA 0.0087
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0087
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0086
3312 Fatty acid-binding protein, brain FABP7 0.0086
106 Cannabinoid receptor 2 CNR2 0.0086
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0085
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0085
162 Retinoic acid receptor gamma-1 RARG 0.0085
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0085
1039 Histone deacetylase 9 HDAC9 0.0084
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0084
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0084
1618 High affinity nerve growth factor receptor NTRK1 0.0083
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0083
768 FK506-binding protein 1A FKBP1A 0.0083
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0083
1256 5-hydroxytryptamine 6 receptor HTR6 0.0082
611 Retinal dehydrogenase 1 ALDH1A1 0.0082
185 Vasopressin V1a receptor AVPR1A 0.0082
1648 Elastin ELN 0.0081
165 FL cytokine receptor FLT3 0.0081
2230 Catalase CAT 0.008
3249 Catalase katA 0.008
3625 Catalase katA 0.008
4539 Catalase katA 0.008
4941 Catalase katB 0.008
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.008
5300 Antigen peptide transporter 1 TAP1 0.008
322 Vasopressin V2 receptor AVPR2 0.008
1196 Complement decay-accelerating factor CD55 0.008
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
3810 Catechol O-methyltransferase COMT 0.0079
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0079
3426 Glutamine synthetase glnA 0.0079
3987 Glutamine synthetase GLUL 0.0079
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0079
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0078
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0077
563 Thyroid peroxidase TPO 0.0076
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0076
273 Apoptosis regulator Bcl-2 BCL2 0.0076
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0075
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0075
3809 Estrogen-related receptor gamma ESRRG 0.0075
1541 Metalloproteinase mmp20 0.0074
251 Alcohol dehydrogenase 1A ADH1A 0.0074
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0073
131 Synaptic vesicular amine transporter SLC18A2 0.0073
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0073
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0073
130 Prostacyclin synthase PTGIS 0.0072
239 Coagulation factor X F10 0.0072
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0071
814 Ryanodine receptor 1 RYR1 0.0071
1275 Estrogen sulfotransferase SULT1E1 0.0071
284 DNA-directed RNA polymerase beta chain rpoB 0.0071
5773 DNA-directed RNA polymerase beta chain rpoB 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
54 Prothrombin F2 0.007
6043 Putative G-protein coupled receptor 44 GPR44 0.007
319 Opioid receptor, sigma 1 OPRS1 0.007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0069
2808 Chloramphenicol acetyltransferase 3 cat3 0.0069
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0069
183 Vascular endothelial growth factor A VEGFA 0.0068
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0068
1483 Membrane copper amine oxidase AOC3 0.0067
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0067
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0067
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0067
357 Carbonic anhydrase 2 CA2 0.0067
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0067
4203 Histamine N-methyltransferase HNMT 0.0067
1630 Integrin beta-2 ITGB2 0.0066
24 Thymidylate synthase TMP1 0.0066
359 Thymidylate synthase TYMS 0.0066
2626 Thymidylate synthase thyA 0.0066
2729 Thymidylate synthase thyA 0.0066
5352 Thymidylate synthase THYA 0.0066
3937 Fatty-acid amide hydrolase FAAH 0.0066
444 Alcohol dehydrogenase 1B ADH1B 0.0066
856 Vitamin D3 receptor VDR 0.0066
6103 Arylamine N-acetyltransferase 1 NAT1 0.0065
1852 Microtubule-associated protein 2 MAP2 0.0065
3947 Xanthine dehydrogenase/oxidase XDH 0.0065
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0065
1629 Transcription factor AP-1 JUN 0.0064
2981 Phospholipase A2, membrane associated PLA2G2A 0.0064
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0063
133 Dihydropterate synthase sulI 0.0063
2810 Dr hemagglutinin structural subunit draA 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
634 Squalene monooxygenase SQLE 0.0062
7196 Squalene monooxygenase ERG1 0.0062
5923 Microtubule-associated protein tau MAPT 0.006
5924 Microtubule-associated protein 4 MAP4 0.006
163 D(1B) dopamine receptor DRD5 0.006
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0059
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0059
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0059
4122 Histone deacetylase 2 HDAC2 0.0059
6138 Multidrug resistance protein 3 ABCB4 0.0058
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0058
581 Cytochrome P450 2R1 CYP2R1 0.0058
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0057
5934 Cytochrome P450 26A1 CYP26A1 0.0057
517 Alcohol dehydrogenase 1C ADH1C 0.0057
153 Dopamine beta-hydroxylase DBH 0.0057
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0057
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0057
703 NADPH azoreductase azr 0.0056
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0056
1360 Sphingomyelin phosphodiesterase SMPD1 0.0055
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0054
16 Adenosine A1 receptor ADORA1 0.0054
3086 Plasmepsin-2 Not Available 0.0053
976 Platelet glycoprotein IX GP9 0.0053
850 Vasopressin V1b receptor AVPR1B 0.0053
1178 Adenosine A2a receptor ADORA2A 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0053
6146 High affinity copper uptake protein 1 SLC31A1 0.0052
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0052
4311 tRNA TRDMT1 0.0052
4325 tRNA trmD 0.0052
4328 tRNA trmD 0.0052
33 Cystine/glutamate transporter SLC7A11 0.0052
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0052
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0052
3913 Glutamic acid decarboxylase GAD65 0.0052
6126 Carbonic anhydrase 7 CA7 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
511 5-hydroxytryptamine 1F receptor HTR1F 0.0051
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0051
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.005
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.005
459 Retinoic acid receptor RXR-alpha RXRA 0.005
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0049
6033 High affinity interleukin-8 receptor A CXCR1 0.0049
267 Plasminogen activator inhibitor 1 SERPINE1 0.0049
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
4217 Telomerase reverse transcriptase TERT 0.0047
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0047
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0047
5787 Angiopoietin-1 receptor TEK 0.0046
2298 Cytochrome P450-cam camC 0.0046
6012 Tryptophan 2,3-dioxygenase TDO2 0.0045
1992 Vitamin D-binding protein GC 0.0045
527 Prostacyclin receptor PTGIR 0.0045
904 Glutathione S-transferase P GSTP1 0.0045
2207 Rhodopsin RHO 0.0045
4103 Proteasome subunit beta type 2 PSMB2 0.0045
4102 Proteasome subunit beta type 5 PSMB5 0.0045
4101 Proteasome subunit beta type 1 PSMB1 0.0045
474 Acetylcholinesterase ACHE 0.0045
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0045
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0044
6221 Steroid hormone receptor ERR1 ESRRA 0.0044
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0044
6044 Serum paraoxonase/lactonase 3 PON3 0.0043
6149 Solute carrier family 22 member 10 SLC22A10 0.0043
3904 Alanine aminotransferase 2 GPT2 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
1864 RET proto-oncogene RET 0.0043
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0043
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0043
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0043
4773 Deoxycytidine kinase DCK 0.0043
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0042
2112 Toll-like receptor 9 TLR9 0.0042
489 Monocarboxylate transporter 2 SLC16A7 0.0041
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0041
3868 Calcineurin subunit B isoform 2 PPP3R2 0.004
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.004
572 Integrin alpha-L ITGAL 0.004
1353 DNA topoisomerase 1 TOP1 0.004
3552 DNA topoisomerase 1 topA 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
4132 Chloride channel protein ClC-Ka CLCNKA 0.0039
3639 Thymidine phosphorylase deoA 0.0039
3936 Thymidine phosphorylase TYMP 0.0039
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6048 Troponin C, skeletal muscle TNNC2 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0038
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0038
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0038
4192 DNA topoisomerase 2-beta TOP2B 0.0038
1525 Heparin-binding growth factor 2 FGF2 0.0037
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0037
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0037
2320 Thymidine kinase, cytosolic TK1 0.0037
936 Ephrin type-A receptor 2 EPHA2 0.0036
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0036
908 Glutathione S-transferase theta-1 GSTT1 0.0036
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0036
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0036
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0036
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0036
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
4226 Uridine phosphorylase 2 UPP2 0.0035
1262 Corticotropin-lipotropin POMC 0.0035
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0035
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
1517 Beta-3 adrenergic receptor ADRB3 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3917 Methylenetetrahydrofolate reductase MTHFR 0.0034
3856 Fibroblast growth factor receptor 3 FGFR3 0.0034
164 Histamine H4 receptor HRH4 0.0033
5880 Thrombopoietin receptor MPL 0.0033
2021 Thrombomodulin THBD 0.0032
4225 Uridine phosphorylase 1 UPP1 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
1650 Heme carrier protein 1 SLC46A1 0.0032
5798 Mitogen-activated protein kinase 11 MAPK11 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
6131 Carbonic anhydrase 14 CA14 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
751 Potassium channel subfamily K member 6 KCNK6 0.0031
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0031
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0031
1268 Neuropeptide S receptor NPSR1 0.0031
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0031
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0031
291 Nitric-oxide synthase, endothelial NOS3 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
413 Amidophosphoribosyltransferase PPAT 0.003
2515 Amidophosphoribosyltransferase purF 0.003
3714 Amidophosphoribosyltransferase purF 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0029
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
172 Potassium channel subfamily K member 1 KCNK1 0.0028
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0028
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6073 Potassium channel subfamily K member 9 KCNK9 0.0028
6072 Potassium channel subfamily K member 3 KCNK3 0.0028
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6500 Phospholipase A2 PLA2G1B 0.0026
1714 Mitogen-activated protein kinase 3 MAPK3 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
1374 Natriuretic peptides B NPPB 0.0026
1827 Gap junction alpha-1 protein GJA1 0.0026
1908 Vascular cell adhesion protein 1 VCAM1 0.0026
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0026
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
759 Free fatty acid receptor 1 FFAR1 0.0024
6824 Tyrosine-protein kinase Lyn LYN 0.0024
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
229 Retinoic acid receptor beta RARB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
730 Retinoic acid receptor alpha RARA 0.0023
2216 Fibroblast growth factor receptor 4 FGFR4 0.0023
2236 Casein kinase II subunit alpha CSNK2A1 0.0023
1792 Tissue-type plasminogen activator PLAT 0.0022
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
4948 Cytochrome c-553 Not Available 0.0022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0022
4923 Cytochrome c3 DvMF_2499 0.0022
4945 Cytochrome c3 Not Available 0.0022
4949 Cytochrome c3 DVU_3171 0.0022
4968 Cytochrome c3 cytc3 0.0022
4997 Cytochrome c3 SO_2727 0.0022
5219 Cytochrome c3 cyd 0.0022
4902 Nine-heme cytochrome c Ddes_2038 0.0022
3189 High-molecular-weight cytochrome c hmcA 0.0022
2232 Interleukin-5 IL5 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
4954 Soluble cytochrome b558 Not Available 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
4934 Cytochrome c-551 nirM 0.0021
5218 Cytochrome c-551 nirM 0.0021
4925 Cytochrome c-type protein SHP shp 0.0021
4905 Cytochrome c2 Not Available 0.0021
4939 Cytochrome c2 cycA 0.0021
4964 Cytochrome c2 cycA 0.0021
4979 Cytochrome c2 cycA 0.0021
6673 Cytochrome c2 cycA 0.0021
4915 Cytochrome c-550 psbV 0.0021
4959 Cytochrome c-550 psbV 0.0021
5216 Cytochrome c-550 psbV 0.0021
4947 Bacterial hemoglobin vhb 0.0021
4943 Cytochrome c6 petJ 0.0021
4916 Cyanoglobin glbN 0.0021
4975 Cytochrome c-556 RPA3973 0.0021
4984 Neuroglobin NGB 0.0021
4998 Hemoglobin-like protein yjbI yjbI 0.0021
4994 Hemoglobin-like protein HbO glbO 0.0021
3116 Bacterioferritin bfr 0.0021
4906 Bacterioferritin bfr 0.0021
4965 Bacterioferritin bfr 0.0021
4936 Cytochrome c2 iso-2 Not Available 0.0021
4907 Cytochrome c-L moxG 0.0021
6865 Cytochrome c-L moxG 0.0021
4909 CooA protein cooA 0.0021
4942 Diheme cytochrome c napB napB 0.0021
644 Heme oxygenase 2 HMOX2 0.0021
4982 Heme oxygenase 2 pbsA2 0.0021
4981 Iron-starvation protein PigA pigA 0.0021
4961 Hemophore HasA hasA 0.0021
4910 Cytoglobin CYGB 0.0021
5000 HemO hemO 0.0021
4935 Cytochrome c-554 cycA1 0.0021
4971 Nonaheme cytochrome c hmcA 0.0021
4976 Apocytochrome f petA 0.0021
6407 Apocytochrome f petA 0.0021
4904 Cytochrome c family protein GSU1996 0.0021
4989 Cytochrome c551 peroxidase ccp 0.0021
5222 Cytochrome c551 peroxidase ccpA 0.0021
4999 Cytochrome P450 165B3 CYP165B3 0.0021
4764 Cytochrome P450 165C4 CYP165C4 0.0021
4960 Putative cytochrome P450-family protein SCO7417 0.0021
4931 Cytochrome P450 167A1 CYP167A1 0.0021
4926 Heme-based aerotactic transducer hemAT hemAT 0.0021
4937 Cytochrome oxidase subunit II rcoxA 0.0021
4903 Methyl-accepting chemotaxis protein Tar4 0.0021
4972 P450cin cinA 0.0021
4993 Hydroxylamine oxidoreductase hao1 0.0021
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0021
4922 Cytochrome c, putative SO_4144 0.0021
4952 Catalase/peroxidase katA 0.0021
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0021
3093 Catalase HPII katE 0.0021
605 Fumarate reductase flavoprotein subunit frdA 0.0021
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0021
3673 Fumarate reductase flavoprotein subunit fccA 0.0021
4912 Fumarate reductase flavoprotein subunit ifcA 0.0021
6549 Fumarate reductase flavoprotein subunit frdA 0.0021
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0021
1053 BC269730_2 FADS1 0.0021
1395 Sodium/calcium exchanger 1 SLC8A1 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
400 Coagulation factor IX F9 0.002
5461 Coagulation factor IX F9 0.002
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
6218 Pannexin-1 PANX1 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
4386 Hemoglobin-like protein HbN glbN 0.0018
6042 Prostaglandin reductase 2 PTGR2 0.0018
1253 Interferon gamma IFNG 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0018
604 Vitamin K-dependent protein Z PROZ 0.0018
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
683 Potassium transporter GK0582 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
268 Adenosine A2b receptor ADORA2B 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
896 Glutathione S-transferase Mu 1 GSTM1 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
3830 Calreticulin CALR 0.0017
3221 Cytochrome c4 cc4 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
76 Nitric-oxide synthase, brain NOS1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
4920 Peroxidase/catalase katG 0.0016
173 Toll-like receptor 7 TLR7 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
822 Aldose reductase AKR1B1 0.0016
2119 Cytochrome b5 CYB5A 0.0016
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0015
4990 PpcA ppcA 0.0015
3233 Bile acid receptor NR1H4 0.0015
4988 Sulfite oxidase, mitochondrial SUOX 0.0015
3375 Acidic cytochrome c3 Not Available 0.0015
4037 Hypothetical protein GPX1 0.0015
4297 Hypothetical protein SP_1951 0.0015
4521 Hypothetical protein BC_2969 0.0015
4540 Hypothetical protein TM_1070 0.0015
4555 Hypothetical protein MT1739 0.0015
4569 Hypothetical protein mshD 0.0015
4578 Hypothetical protein PA3270 0.0015
4747 Hypothetical protein PA3967 0.0015
5177 Hypothetical protein TM_0096 0.0015
5194 Hypothetical protein PA1204 0.0015
5240 Hypothetical protein Rv2991 0.0015
5370 Hypothetical protein TM_1158 0.0015
5710 Hypothetical protein Tb927.5.1360 0.0015
2915 Sensor protein fixL fixL 0.0015
4944 Sensor protein fixL fixL 0.0015
3570 Cytochrome P450 152A1 cypC 0.0015
4385 Cytochrome c' Not Available 0.0015
4967 Cytochrome c' cycA 0.0015
5038 Cytochrome c' Not Available 0.0015
5223 Cytochrome c' cycP 0.0015
4992 Cytochrome c peroxidase Not Available 0.0015
4289 Cytochrome P450 TT_P0059 0.0015
6262 Cytochrome P450 staP 0.0015
4813 Heme oxygenase hmuO 0.0015
5769 Heme oxygenase Not Available 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
1341 Histamine H3 receptor HRH3 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
65 Matrix metalloproteinase-9 Not Available 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
798 Osteocalcin BGLAP 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
3670 Soluble cytochrome b562 precursor cybC 0.0014
3411 Cytochrome P450 121 cyp121 0.0014
3291 Cytochrome c-552 cycA 0.0013
4927 Cytochrome c-552 nrfA 0.0013
4938 Cytochrome c-552 cycA 0.0013
4953 Cytochrome c-552 nrfA 0.0013
5217 Cytochrome c-552 cycM 0.0013
2617 Nitric oxide synthase oxygenase nos 0.0013
2701 Nitric oxide synthase oxygenase nos 0.0013
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
3102 Flavohemoprotein hmp 0.0013
4969 Flavohemoprotein hmp 0.0013
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
369 Coagulation factor VII F7 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
2972 6-deoxyerythronolide B hydroxylase eryF 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0012
6165 Copper-transporting ATPase 1 ATP7A 0.0012
3957 Adenosine deaminase ADA 0.0011
4608 Putative cytochrome P450 SCO1207 0.0011
4963 Putative cytochrome P450 SCO2884 0.0011
6254 Putative cytochrome P450 SCO6998 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
358 Cystathionine beta-synthase CBS 0.0011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
693 Hemoglobin subunit beta HBB 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
283 SEC14-like protein 2 SEC14L2 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
6268 Hydroxyacid oxidase 1 HAO1 0.001
760 Fibroblast growth factor 1 FGF1 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
810 Heme oxygenase 1 HMOX1 0.0009
3391 Heme oxygenase 1 pbsA1 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6677 Myelin P2 protein PMP2 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
1184 Interferon beta IFNB1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
3689 Endoglucanase A celA 0.0004
3814 Complement C1r subcomponent C1R 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
1439 Lactotransferrin LTF 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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