DT-Web: DB01229

Identification

Name

Paclitaxel

Accession Number

DB01229 (APRD00259, DB05261, DB05927)

Type

small molecule

Description

A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS brevifolia. It stabilizes microtubules in their polymerized form leading to cell death. [PubChem] ABI-007 (Abraxane) is the latest attempt to improve upon paclitaxel, one of the leading chemotherapy treatments. Both drugs contain the same active agent, but Abraxane is delivered by a nanoparticle technology that binds to albumin, a natural protein, rather than the toxic solvent known as Cremophor. It is thought that delivering paclitaxel with this technology will cause fewer hypersensitivity reactions and possibly lead to greater drug uptake in tumors.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

853.9061

Groups

approved

Monoisotopic Weight

853.330955345

Pharmacology

Indication

Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane(R) is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.

Mechanism of action

Paclitaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, paclitaxel arrests their function by having the opposite effect; it hyper-stabilizes their structure. This destroys the cell's ability to use its cytoskeleton in a flexible manner. Specifically, paclitaxel binds to the β subunit of tubulin. Tubulin is the "building block" of mictotubules, and the binding of paclitaxel locks these building blocks in place. The resulting microtubule/paclitaxel complex does not have the ability to disassemble. This adversely affects cell function because the shortening and lengthening of microtubules (termed dynamic instability) is necessary for their function as a transportation highway for the cell. Chromosomes, for example, rely upon this property of microtubules during mitosis. Further research has indicated that paclitaxel induces programmed cell death (apoptosis) in cancer cells by binding to an apoptosis stopping protein called Bcl-2 (B-cell leukemia 2) and thus arresting its function.

Absorption

When a 24 hour infusion of 135 mg/m^2 is given to ovarian cancer patients, the maximum plasma concentration (Cmax) is 195 ng/mL, while the AUC is 6300 ngoh/mL.

Protein binding

89%-98% bound to plasma protein. The presence of cimetidine, ranitidine, dexamethasone, or diphenhydramine did not affect protein binding of paclitaxel.

Biotransformation

Hepatic. In vitro studies with human liver microsomes and tissue slices showed that paclitaxel was metabolized primarily to 6a-hydrox-ypaclitaxel by the cytochrome P450 isozyme CYP2C8; and to two minor metabolites, 3’-p-hydroxypaclitaxel and 6a, 3’-p-dihydroxypaclitaxel, by CYP3A4.

Route of elimination

In 5 patients administered a 225 or 250 mg/m2 dose of radiolabeled paclitaxel as a 3-hour infusion, a mean of 71% of the radioactivity was excreted in the feces in 120 hours, and 14% was recovered in the urine.

Toxicity

Rat (ipr) LD₅₀=32530 µg/kg. Symptoms of overdose include bone marrow suppression, peripheral neurotoxicity, and mucositis. Overdoses in pediatric patients may be associated with acute ethanol toxicity.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Aprepitant	Aprepitant may change levels of the chemotherapy agent, paclitaxel.
Axitinib	Avoid combination due to potential for decrease in serum concentration of axitinib.
Carboplatin	Platinum derivatives such as carboplatin may enhance the myelosuppressive effect of taxane derivatives such as paclitaxel. Administer taxane derivative before platinum derivative when given as sequential infusions to limit toxicity. Administering the taxane derivative before the platinum derivative seems prudent.
Cisplatin	Cisplatin increases the effect and toxicity of paclitaxel
Clozapine	Avoid combination due to the potential enhancement of agranulocytosis by clozapine.
Conivaptan	Avoid combination because it will likely increase the serum concentration of CYP3A4 substrates.
Etravirine	Paclitaxel, when used concomitantly with NNRTIs, may experience an increase in serum concentration. It is recommended to monitor for paclitaxel toxicity.
Gemcitabine	Paclitaxel increases the effect/toxicity of gemcitabine
Natalizumab	Avoid combination due to the increased risk of infection.
Pazopanib	Pazopanib increases exposure of paclitaxel
Pimecrolimus	Avoid combination due to the enhancement of adverse effects of immunosuppressants.
Quinupristin	This combination presents an increased risk of toxicity
St. John's Wort	Avoid combination due to potential decrease in serum concentration of paclitaxel.
Tacrolimus	Avoid combination of topical tacrolimus due to the potential enhancement of adverse effects of immunosuppressants.
Telithromycin	Telithromycin may reduce clearance of Paclitaxel. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Paclitaxel if Telithromycin is initiated, discontinued or dose changed.
Tolbutamide	Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Paclitaxel. Consider alternate therapy or monitor for changes in Paclitaxel therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Concomitant therapy may also increase Trastuzumab serum concentration and decrease Paclitaxel serum concentrations. Monitor closely for adverse events and therapeutic response.
Valrubicin	The taxane derivative, Paclitaxel, may increase Valrubicin toxicity. Consider alternate therapy or monitor for toxic effects.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of paclitaxel by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of paclitaxel if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Avoid echinacea.
Avoid grapefruit and grapefruit juice due to potential increase of paclitaxel.

Tubulin beta-1 chain
Name	Tubulin beta-1 chain
Gene Name	TUBB1
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Cheung CH, Chen HH, Kuo CC, Chang CY, Coumar MS, Hsieh HP, Chang JY: Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers. Mol Cancer. 2009 Jul 3;8:43. - Pubmed Horwitz SB: Mechanism of action of taxol. Trends Pharmacol Sci. 1992 Apr;13(4):134-6. - Pubmed Kovacs P, Csaba G, Pallinger E, Czaker R: Effects of taxol treatment on the microtubular system and mitochondria of Tetrahymena. Cell Biol Int. 2007 Jul;31(7):724-32. Epub 2007 Jan 14. - Pubmed
DTHybrid score	0.4684
Apoptosis regulator Bcl-2
Name	Apoptosis regulator Bcl-2
Gene Name	BCL2
Pharmacological action	yes
Actions	inhibitor
References	Gan Y, Wientjes MG, Au JL: Expression of basic fibroblast growth factor correlates with resistance to paclitaxel in human patient tumors. Pharm Res. 2006 Jun;23(6):1324-31. Epub 2006 Jun 8. - Pubmed Thomadaki H, Talieri M, Scorilas A: Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS. Biol Chem. 2006 Aug;387(8):1081-6. - Pubmed Yoshino T, Shiina H, Urakami S, Kikuno N, Yoneda T, Shigeno K, Igawa M: Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6116-24. - Pubmed Matsuyoshi S, Shimada K, Nakamura M, Ishida E, Konishi N: Bcl-2 phosphorylation has pathological significance in human breast cancer. Pathobiology. 2006;73(4):205-12. - Pubmed Zhang X, Wang Q, Ling MT, Wong YC, Leung SC, Wang X: Anti-apoptotic role of TWIST and its association with Akt pathway in mediating taxol resistance in nasopharyngeal carcinoma cells. Int J Cancer. 2007 May 1;120(9):1891-8. - Pubmed
DTHybrid score	0.4438
Nuclear receptor subfamily 1 group I member 2
Name	Nuclear receptor subfamily 1 group I member 2
Gene Name	NR1I2
Pharmacological action	unknown
Actions	inducer
References	Harmsen S, Meijerman I, Beijnen JH, Schellens JH: Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor. Cancer Chemother Pharmacol. 2009 Jun;64(1):35-43. doi: 10.1007/s00280-008-0842-3. Epub 2008 Oct 7. - Pubmed
DTHybrid score	0.4365
Microtubule-associated protein 4
Name	Microtubule-associated protein 4
Gene Name	MAP4
Pharmacological action	yes
Actions	Not Available
References	McGrogan BT, Gilmartin B, Carney DN, McCann A: Taxanes, microtubules and chemoresistant breast cancer. Biochim Biophys Acta. 2008 Apr;1785(2):96-132. Epub 2007 Nov 12. - Pubmed
DTHybrid score	0.3825
Microtubule-associated protein 2
Name	Microtubule-associated protein 2
Gene Name	MAP2
Pharmacological action	yes
Actions	Not Available
References	McGrogan BT, Gilmartin B, Carney DN, McCann A: Taxanes, microtubules and chemoresistant breast cancer. Biochim Biophys Acta. 2008 Apr;1785(2):96-132. Epub 2007 Nov 12. - Pubmed
DTHybrid score	0.4205
Microtubule-associated protein tau
Name	Microtubule-associated protein tau
Gene Name	MAPT
Pharmacological action	yes
Actions	Not Available
References	McGrogan BT, Gilmartin B, Carney DN, McCann A: Taxanes, microtubules and chemoresistant breast cancer. Biochim Biophys Acta. 2008 Apr;1785(2):96-132. Epub 2007 Nov 12. - Pubmed
DTHybrid score	0.3827

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6144
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.6577
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.5175
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. - Pubmed
DTHybrid score	0.5509
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.071
Cytochrome P450 19A1
Name	Cytochrome P450 19A1
Gene Name	CYP19A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4397
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3691

Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	substrate,inhibitor
References	Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed
DTHybrid score	0.338
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Jang SH, Wientjes MG, Au JL: Kinetics of P-glycoprotein-mediated efflux of paclitaxel. J Pharmacol Exp Ther. 2001 Sep;298(3):1236-42. - Pubmed Li D, Jang SH, Kim J, Wientjes MG, Au JL: Enhanced drug-induced apoptosis associated with P-glycoprotein overexpression is specific to antimicrotubule agents. Pharm Res. 2003 Jan;20(1):45-50. - Pubmed Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed Kim S, Kim SS, Bang YJ, Kim SJ, Lee BJ: In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines. Peptides. 2003 Jul;24(7):945-53. - Pubmed Walle UK, Walle T: Taxol transport by human intestinal epithelial Caco-2 cells. Drug Metab Dispos. 1998 Apr;26(4):343-6. - Pubmed Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. - Pubmed Kuo CC, Hsieh HP, Pan WY, Chen CP, Liou JP, Lee SJ, Chang YL, Chen LT, Chen CT, Chang JY: BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer Res. 2004 Jul 1;64(13):4621-8. - Pubmed Li YC, Fung KP, Kwok TT, Lee CY, Suen YK, Kong SK: Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells. Chemotherapy. 2004 Jun;50(2):55-62. - Pubmed Kwak JO, Lee SH, Lee GS, Kim MS, Ahn YG, Lee JH, Kim SW, Kim KH, Lee MG: Selective inhibition of MDR1 (ABCB1) by HM30181 increases oral bioavailability and therapeutic efficacy of paclitaxel. Eur J Pharmacol. 2010 Feb 10;627(1-3):92-8. Epub 2009 Nov 10. - Pubmed Woodahl EL, Crouthamel MH, Bui T, Shen DD, Ho RJ: MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8. Epub 2009 Jan 4. - Pubmed Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. Epub 2009 Apr 11. - Pubmed Noguchi K, Kawahara H, Kaji A, Katayama K, Mitsuhashi J, Sugimoto Y: Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib. Cancer Sci. 2009 Sep;100(9):1701-7. Epub 2009 May 12. - Pubmed
DTHybrid score	0.8384
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Heijn M, Hooijberg JH, Scheffer GL, Szabo G, Westerhoff HV, Lankelma J: Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim Biophys Acta. 1997 May 22;1326(1):12-22. - Pubmed
DTHybrid score	0.4751
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions	substrate,inhibitor
References	Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed Zhou Y, Hopper-Borge E, Shen T, Huang XC, Shi Z, Kuang YH, Furukawa T, Akiyama S, Peng XX, Ashby CR Jr, Chen X, Kruh GD, Chen ZS: Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. Biochem Pharmacol. 2009 Mar 15;77(6):993-1001. Epub 2008 Dec 25. - Pubmed Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD: Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res. 2009 Jan 1;69(1):178-84. - Pubmed
DTHybrid score	0.3363
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	substrate
References	Smith NF, Acharya MR, Desai N, Figg WD, Sparreboom A: Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biol Ther. 2005 Aug;4(8):815-8. - Pubmed
DTHybrid score	0.4067
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhanel M, Spruss T, Bernhardt G, Graeff C, Farber L, Gschaidmeier H, Buschauer A, Fricker G: Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest. 2002 Nov;110(9):1309-18. - Pubmed
DTHybrid score	0.5517
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhanel M, Spruss T, Bernhardt G, Graeff C, Farber L, Gschaidmeier H, Buschauer A, Fricker G: Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest. 2002 Nov;110(9):1309-18. - Pubmed
DTHybrid score	0.5288

Id	Partner name	Gene Name	Score
4200	Cytochrome P450 1A2	CYP1A2	0.3941
6016	Cytochrome P450 2C19	CYP2C19	0.3906
4119	Cytochrome P450 2D6	CYP2D6	0.3755
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.2958
6030	Cytochrome P450 2B6	CYP2B6	0.2415
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.2132
6024	Cytochrome P450 1A1	CYP1A1	0.2093
6013	Cytochrome P450 2E1	CYP2E1	0.1987
587	Serum albumin	ALB	0.1737
6143	Solute carrier family 22 member 7	SLC22A7	0.1493
136	Estrogen receptor	ESR1	0.1466
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1357
5718	Cytochrome P450 2A6	CYP2A6	0.1255
1729	Solute carrier family 22 member 6	SLC22A6	0.1244
20	Prostaglandin G/H synthase 1	PTGS1	0.1242
2164	Multidrug resistance-associated protein 4	ABCC4	0.1205
6142	Solute carrier family 22 member 8	SLC22A8	0.1152
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1126
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.1106
6141	Sodium/bile acid cotransporter	SLC10A1	0.1057
6145	Solute carrier family 22 member 1	SLC22A1	0.1042
6144	Solute carrier family 22 member 2	SLC22A2	0.092
2107	Microtubule-associated protein 1A	MAP1A	0.0917
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0916
2539	Tubulin alpha-1 chain	TUBA4A	0.0889
146	Androgen receptor	AR	0.086
817	DNA topoisomerase 2-alpha	TOP2A	0.0859
161	Tubulin beta chain	TUBB	0.0852
312	Tubulin beta chain	TUB2	0.0852
3939	Amine oxidase [flavin-containing] B	MAOB	0.0791
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0785
6106	Cytochrome P450 2C18	CYP2C18	0.0781
869	Estrogen receptor beta	ESR2	0.077
6137	Multidrug resistance-associated protein 6	ABCC6	0.0718
6147	Solute carrier family 22 member 3	SLC22A3	0.0715
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0715
290	Prostaglandin G/H synthase 2	PTGS2	0.0688
1024	Solute carrier family 22 member 11	SLC22A11	0.0638
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0633
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.062
284	DNA-directed RNA polymerase beta chain	rpoB	0.061
5773	DNA-directed RNA polymerase beta chain	rpoB	0.061
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0593
871	Glucocorticoid receptor	NR3C1	0.0572
756	Sex hormone-binding globulin	SHBG	0.0572
70	Type-1 angiotensin II receptor	AGTR1	0.0559
6031	Cytochrome P450 3A43	CYP3A43	0.055
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0544
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0544
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0542
492	Histamine H1 receptor	HRH1	0.0541
118	Organic cation/carnitine transporter 2	SLC22A5	0.0533
3947	Xanthine dehydrogenase/oxidase	XDH	0.053
260	Cytochrome P450 51	ERG11	0.052
761	Cytochrome P450 51	ERG11	0.052
3163	Cytochrome P450 51	cyp51	0.052
731	HIV-1 protease	HIV-1 protease	0.0506
844	Epidermal growth factor receptor	EGFR	0.0489
847	Mu-type opioid receptor	OPRM1	0.0488
468	Cytochrome P450 4A11	CYP4A11	0.0485
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0475
614	Progesterone receptor	PGR	0.0472
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0459
824	Sodium-dependent serotonin transporter	SLC6A4	0.0457
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0454
2565	Tubulin beta-4 chain	TUBB4	0.0451
2578	Tubulin beta-3 chain	TUBB3	0.0445
2444	Tubulin beta-4q chain	TUBB4Q	0.0439
2449	Tubulin alpha-3 chain	TUBA1A	0.043
6136	Multidrug resistance-associated protein 5	ABCC5	0.0419
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0411
275	Arachidonate 5-lipoxygenase	ALOX5	0.0409
2480	Tubulin alpha-8 chain	TUBA8	0.0407
2601	Tubulin alpha-2 chain	TUBA3C	0.0407
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0407
2499	Tubulin beta-2C chain	TUBB2C	0.0407
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0406
4120	NADPH--cytochrome P450 reductase	POR	0.0389
2536	Tubulin alpha-6 chain	TUBA1C	0.0385
2342	Tubulin alpha-ubiquitous chain	TUBA1B	0.0385
831	D(2) dopamine receptor	DRD2	0.0372
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0369
6085	Fatty acid-binding protein, intestinal	FABP2	0.0361
556	Alpha-1A adrenergic receptor	ADRA1A	0.0358
3587	Gastrotropin	FABP6	0.0356
738	Monocarboxylate transporter 1	SLC16A1	0.0353
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0353
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0352
467	Delta-type opioid receptor	OPRD1	0.0349
380	Cytochrome P450 17A1	CYP17A1	0.0347
4604	Liver carboxylesterase 1	CES1	0.0346
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0343
4773	Deoxycytidine kinase	DCK	0.0338
504	Mast/stem cell growth factor receptor	KIT	0.0335
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0335
833	Organic cation/carnitine transporter 1	SLC22A4	0.0322
6138	Multidrug resistance protein 3	ABCB4	0.031
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0309
33	Cystine/glutamate transporter	SLC7A11	0.0308
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0303
696	Kappa-type opioid receptor	OPRK1	0.0302
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0299
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0296
4116	Dihydropteroate synthetase	Not Available	0.0296
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0295
88	Retinoic acid receptor RXR-beta	RXRB	0.0293
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.029
4192	DNA topoisomerase 2-beta	TOP2B	0.0287
3923	Cholinesterase	BCHE	0.0287
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0285
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0285
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0284
737	Mineralocorticoid receptor	NR3C2	0.0281
6182	Cytochrome P450 2J2	CYP2J2	0.0281
477	DNA topoisomerase 4 subunit A	parC	0.028
886	DNA topoisomerase 4 subunit A	parC	0.028
6226	DNA topoisomerase 4 subunit A	parC	0.028
404	DNA gyrase subunit A	gyrA	0.0275
6224	DNA gyrase subunit A	gyrA	0.0275
6167	Organic solute transporter subunit beta	OSTB	0.0273
6166	Organic solute transporter subunit alpha	OSTA	0.0273
24	Thymidylate synthase	TMP1	0.0271
359	Thymidylate synthase	TYMS	0.0271
2626	Thymidylate synthase	thyA	0.0271
2729	Thymidylate synthase	thyA	0.0271
5352	Thymidylate synthase	THYA	0.0271
103	Muscarinic acetylcholine receptor M1	CHRM1	0.027
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0268
3941	Amine oxidase [flavin-containing] A	MAOA	0.0267
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0265
632	Alpha-1B adrenergic receptor	ADRA1B	0.0261
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0259
373	Transthyretin	TTR	0.0255
904	Glutathione S-transferase P	GSTP1	0.0252
6220	Aryl hydrocarbon receptor	AHR	0.0252
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0251
228	Beta platelet-derived growth factor receptor	PDGFRB	0.025
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0248
1353	DNA topoisomerase 1	TOP1	0.0248
3552	DNA topoisomerase 1	topA	0.0248
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0248
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0247
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0245
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0244
318	Alpha-2A adrenergic receptor	ADRA2A	0.0244
2907	Oxysterols receptor LXR-beta	NR1H2	0.0242
6283	Oxysterols receptor LXR-alpha	NR1H3	0.0242
3611	Cytidine deaminase	cdd	0.0237
3707	Cytidine deaminase	cdd	0.0237
4211	Cytidine deaminase	CDA	0.0237
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0233
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0232
23	D(1A) dopamine receptor	DRD1	0.0232
908	Glutathione S-transferase theta-1	GSTT1	0.0232
2808	Chloramphenicol acetyltransferase 3	cat3	0.0232
407	Vascular endothelial growth factor receptor 2	KDR	0.023
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0228
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0226
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0225
563	Thyroid peroxidase	TPO	0.0223
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0222
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0221
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.022
6228	Nuclear receptor coactivator 1	NCOA1	0.022
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0219
766	Beta-2 adrenergic receptor	ADRB2	0.0219
465	Calmodulin	CALM1	0.0219
6241	Nuclear receptor coactivator 2	NCOA2	0.0218
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0218
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0212
2021	Thrombomodulin	THBD	0.021
26	Vascular endothelial growth factor receptor 3	FLT4	0.021
5626	Nucleoside diphosphate kinase B	NME2	0.0209
638	D(3) dopamine receptor	DRD3	0.0208
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0208
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0208
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0204
713	Sodium-dependent dopamine transporter	SLC6A3	0.0203
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0203
683	Potassium transporter	GK0582	0.0203
1010	Cytochrome P450 51A1	CYP51A1	0.0202
1629	Transcription factor AP-1	JUN	0.0201
32	Vascular endothelial growth factor receptor 1	FLT1	0.02
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.02
226	Gonadotropin-releasing hormone receptor	GNRHR	0.02
6020	Aldehyde oxidase	AOX1	0.0199
952	Dipeptidyl peptidase 4	DPP4	0.0198
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0198
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0197
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0196
1757	Myeloperoxidase	MPO	0.0195
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0195
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0192
629	Alpha-2B adrenergic receptor	ADRA2B	0.0191
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0187
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0186
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0185
3809	Estrogen-related receptor gamma	ESRRG	0.0184
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0183
122	P2Y purinoceptor 12	P2RY12	0.0183
49	Endothelin B receptor	EDNRB	0.0182
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0181
811	Translocator protein	TSPO	0.0181
3270	Elongation factor G	fusA	0.0181
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0181
469	Annexin A1	ANXA1	0.0178
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0177
165	FL cytokine receptor	FLT3	0.0177
6044	Serum paraoxonase/lactonase 3	PON3	0.0176
1192	Sulfotransferase 1A1	SULT1A1	0.0175
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0175
148	Lutropin-choriogonadotropic hormone receptor	LHCGR	0.0175
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0173
193	Beta-1 adrenergic receptor	ADRB1	0.0173
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0173
578	Endothelin-1 receptor	EDNRA	0.0172
702	UMP-CMP kinase	CMPK1	0.0171
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0169
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0169
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0169
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0169
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0169
1178	Adenosine A2a receptor	ADORA2A	0.0168
5294	Nucleoside diphosphate kinase A	NME1	0.0168
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0167
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0165
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0162
1650	Heme carrier protein 1	SLC46A1	0.0161
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.016
7	Nitric oxide synthase, inducible	NOS2	0.0159
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0158
789	Alpha-1D adrenergic receptor	ADRA1D	0.0157
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0157
4203	Histamine N-methyltransferase	HNMT	0.0157
887	DNA gyrase subunit B	gyrB	0.0156
4150	DNA gyrase subunit B	gyrB	0.0156
6225	DNA gyrase subunit B	gyrB	0.0156
1656	CYP2B protein	CYP2B	0.0156
232	Corticosteroid-binding globulin	SERPINA6	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
5787	Angiopoietin-1 receptor	TEK	0.0153
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0151
3810	Catechol O-methyltransferase	COMT	0.015
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0149
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0149
594	Thyroxine-binding globulin	SERPINA7	0.0148
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0148
84	Nuclear receptor 0B1	NR0B1	0.0147
723	Cytosolic phospholipase A2	PLA2G4A	0.0147
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0146
891	Dihydropteroate synthase	folP	0.0146
5359	Dihydropteroate synthase	folP	0.0146
7175	Dihydropteroate synthase	sulI	0.0146
365	Dihydrofolate reductase	DHFR	0.0145
2381	Dihydrofolate reductase	DFR1	0.0145
2833	Dihydrofolate reductase	Not Available	0.0145
2931	Dihydrofolate reductase	folA	0.0145
3544	Dihydrofolate reductase	folA	0.0145
3682	Dihydrofolate reductase	folA	0.0145
6642	Dihydrofolate reductase	folA	0.0145
6756	Dihydrofolate reductase	dfrA	0.0145
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0144
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0143
777	Tumor necrosis factor	TNF	0.0139
6146	High affinity copper uptake protein 1	SLC31A1	0.0139
378	Alpha-2C adrenergic receptor	ADRA2C	0.0138
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0138
758	Thyroid hormone receptor alpha	THRA	0.0138
1792	Tissue-type plasminogen activator	PLAT	0.0138
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0137
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0135
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0132
461	Glycine receptor subunit alpha-3	GLRA3	0.0132
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
5934	Cytochrome P450 26A1	CYP26A1	0.0131
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0131
3307	Acriflavine resistance protein B	acrB	0.013
4237	50S ribosomal protein L22	rplV	0.013
1830	5'-nucleotidase	NT5E	0.0129
117	Sterol O-acyltransferase 1	SOAT1	0.0129
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0128
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0128
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0127
992	Protein tyrosine kinase 2 beta	PTK2B	0.0126
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0125
6163	Copper-transporting ATPase 2	ATP7B	0.0125
6165	Copper-transporting ATPase 1	ATP7A	0.0125
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0125
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0125
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0125
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0125
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0124
346	Thyroid hormone receptor beta-1	THRB	0.0124
6168	Solute carrier family 22 member 16	SLC22A16	0.0123
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0123
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0123
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0123
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0123
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0123
125	DNA polymerase beta	POLB	0.0123
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0122
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0122
818	50S ribosomal protein L10	rplJ	0.0122
131	Synaptic vesicular amine transporter	SLC18A2	0.0122
3932	Glutathione S-transferase A2	GSTA2	0.0121
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0121
3957	Adenosine deaminase	ADA	0.0121
4238	50S ribosomal protein L4	rplD	0.012
5578	50S ribosomal protein L4	rplD	0.012
6173	50S ribosomal protein L4	rplD	0.012
6219	50S ribosomal protein L4	rplD	0.012
896	Glutathione S-transferase Mu 1	GSTM1	0.012
6171	Solute carrier family 28 member 3	SLC28A3	0.012
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0119
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0119
432	D(4) dopamine receptor	DRD4	0.0119
6149	Solute carrier family 22 member 10	SLC22A10	0.0119
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0118
474	Acetylcholinesterase	ACHE	0.0117
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0116
16	Adenosine A1 receptor	ADORA1	0.0116
124	Histamine H2 receptor	HRH2	0.0116
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0116
293	Gamma-glutamyl hydrolase	GGH	0.0115
427	Substance-P receptor	TACR1	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
814	Ryanodine receptor 1	RYR1	0.0114
6210	Tubulin delta chain	TUBD1	0.0114
6212	Tubulin gamma-1 chain	TUBG1	0.0114
6211	Tubulin epsilon chain	TUBE1	0.0114
4228	Keratin, type II cytoskeletal 7	KRT7	0.0114
1050	Bile salt sulfotransferase	SULT2A1	0.0113
716	5-hydroxytryptamine 7 receptor	HTR7	0.0113
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0113
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0113
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0113
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0113
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0111
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0111
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0111
3856	Fibroblast growth factor receptor 3	FGFR3	0.011
6014	Cytochrome P450 2A13	CYP2A13	0.0109
6102	Arylamine N-acetyltransferase 2	NAT2	0.0108
2443	Azurin	azu	0.0108
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0107
5818	Folate receptor alpha	FOLR1	0.0107
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0106
780	Retinoic acid receptor RXR-gamma	RXRG	0.0105
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0105
823	Fibroblast growth factor receptor 2	FGFR2	0.0104
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0104
94	5-hydroxytryptamine 4 receptor	HTR4	0.0101
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0101
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0101
4122	Histone deacetylase 2	HDAC2	0.01
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.01
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.01
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0098
183	Vascular endothelial growth factor A	VEGFA	0.0098
283	SEC14-like protein 2	SEC14L2	0.0098
1569	G1/S-specific cyclin-D1	CCND1	0.0097
571	Melatonin receptor type 1A	MTNR1A	0.0097
362	Melatonin receptor type 1B	MTNR1B	0.0097
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0096
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0096
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0094
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0092
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0091
162	Retinoic acid receptor gamma-1	RARG	0.0091
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.009
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.009
936	Ephrin type-A receptor 2	EPHA2	0.009
239	Coagulation factor X	F10	0.009
199	Monocarboxylate transporter 8	SLC16A2	0.0089
291	Nitric-oxide synthase, endothelial	NOS3	0.0089
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0089
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
484	Tyrosine-protein kinase ABL2	ABL2	0.0088
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.0087
86	SEC14-like protein 4	SEC14L4	0.0087
375	SEC14-like protein 3	SEC14L3	0.0087
4076	Diacylglycerol kinase alpha	DGKA	0.0087
899	Glutathione S-transferase Mu 3	GSTM3	0.0087
905	Glutathione transferase omega-1	GSTO1	0.0087
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0086
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0086
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0086
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0086
3830	Calreticulin	CALR	0.0086
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0085
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0085
921	Glutamate receptor 2	GRIA2	0.0083
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0083
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0083
267	Plasminogen activator inhibitor 1	SERPINE1	0.0083
708	Alpha-tocopherol transfer protein	TTPA	0.0082
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0082
295	Carbonic anhydrase 1	CA1	0.0082
76	Nitric-oxide synthase, brain	NOS1	0.0082
68	Cannabinoid receptor 1	CNR1	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0081
2216	Fibroblast growth factor receptor 4	FGFR4	0.0081
528	5-hydroxytryptamine 1E receptor	HTR1E	0.008
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.008
6837	Serine/threonine-protein kinase 17B	STK17B	0.008
6824	Tyrosine-protein kinase Lyn	LYN	0.008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0079
6035	Nuclear receptor ROR-beta	RORB	0.0079
459	Retinoic acid receptor RXR-alpha	RXRA	0.0079
6036	Eosinophil peroxidase	EPX	0.0079
1714	Mitogen-activated protein kinase 3	MAPK3	0.0079
1618	High affinity nerve growth factor receptor	NTRK1	0.0078
489	Monocarboxylate transporter 2	SLC16A7	0.0078
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0078
2599	Tyrosine-protein kinase HCK	HCK	0.0078
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0078
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.0077
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0077
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0077
997	Protein kinase C beta type	PRKCB	0.0077
5300	Antigen peptide transporter 1	TAP1	0.0075
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0075
229	Retinoic acid receptor beta	RARB	0.0075
6221	Steroid hormone receptor ERR1	ESRRA	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0074
1541	Metalloproteinase	mmp20	0.0074
2391	Ferrochelatase	hemH	0.0074
6502	Ferrochelatase	DKFZp686P18130	0.0074
1591	Ferrochelatase, mitochondrial	FECH	0.0074
730	Retinoic acid receptor alpha	RARA	0.0073
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0073
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0073
705	Glutamate receptor 1	GRIA1	0.0073
1630	Integrin beta-2	ITGB2	0.0071
634	Squalene monooxygenase	SQLE	0.0071
7196	Squalene monooxygenase	ERG1	0.0071
319	Opioid receptor, sigma 1	OPRS1	0.0071
54	Prothrombin	F2	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
890	Niemann-Pick C1-like protein 1	NPC1L1	0.007
1970	Protein kinase C alpha type	PRKCA	0.007
1649	Small inducible cytokine A2	CCL2	0.007
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0069
244	Angiotensin-converting enzyme	ACE	0.0068
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0068
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0068
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0068
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0067
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0067
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0067
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0067
1196	Complement decay-accelerating factor	CD55	0.0067
592	Carbonic anhydrase 4	CA4	0.0067
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0066
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0066
144	Hemoglobin subunit alpha	HBA1	0.0066
810	Heme oxygenase 1	HMOX1	0.0065
3391	Heme oxygenase 1	pbsA1	0.0065
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0065
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0065
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0065
357	Carbonic anhydrase 2	CA2	0.0064
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0064
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0064
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0064
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0064
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0064
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0064
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0064
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0064
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0064
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0064
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0064
6559	Cytochrome c oxidase subunit 2	ctaC	0.0064
6669	Cytochrome c oxidase subunit 2	ctaC	0.0064
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0064
6558	Cytochrome c oxidase subunit 1	ctaD	0.0064
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1760	Aminopeptidase N	ANPEP	0.0063
6843	Aminopeptidase N	pepN	0.0063
133	Dihydropterate synthase	sulI	0.0063
1176	Mitogen-activated protein kinase 1	MAPK1	0.0063
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0062
751	Potassium channel subfamily K member 6	KCNK6	0.0062
6043	Putative G-protein coupled receptor 44	GPR44	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
2232	Interleukin-5	IL5	0.0059
1593	Mucin-2	MUC2	0.0059
2540	Choloylglycine hydrolase	cbh	0.0059
1483	Membrane copper amine oxidase	AOC3	0.0059
6174	50S ribosomal protein L32	rpmF	0.0058
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0058
163	D(1B) dopamine receptor	DRD5	0.0057
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0057
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0057
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0057
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0057
6151	Monocarboxylate transporter 10	SLC16A10	0.0057
172	Potassium channel subfamily K member 1	KCNK1	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
558	Solute carrier family 12 member 1	SLC12A1	0.0056
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
6501	Fatty acid-binding protein, liver	FABP1	0.0055
106	Cannabinoid receptor 2	CNR2	0.0054
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0054
3086	Plasmepsin-2	Not Available	0.0053
572	Integrin alpha-L	ITGAL	0.0053
3601	Dihydropteroate synthase 1	folP1	0.0053
3807	Dihydropteroate synthase 1	folP1	0.0053
3808	Dihydropteroate synthase 2	folP2	0.0053
2417	Chloramphenicol acetyltransferase	cat	0.0053
3278	Chloramphenicol acetyltransferase	cat	0.0053
2112	Toll-like receptor 9	TLR9	0.0053
2810	Dr hemagglutinin structural subunit	draA	0.0052
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0052
775	Acetyl-CoA carboxylase 2	ACACB	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
268	Adenosine A2b receptor	ADORA2B	0.0051
976	Platelet glycoprotein IX	GP9	0.0051
153	Dopamine beta-hydroxylase	DBH	0.0051
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0051
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.005
1275	Estrogen sulfotransferase	SULT1E1	0.005
1123	Eosinophil cationic protein	RNASE3	0.0049
856	Vitamin D3 receptor	VDR	0.0049
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0048
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0048
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0048
517	Alcohol dehydrogenase 1C	ADH1C	0.0048
2236	Casein kinase II subunit alpha	CSNK2A1	0.0047
6218	Pannexin-1	PANX1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
1648	Elastin	ELN	0.0046
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0046
6500	Phospholipase A2	PLA2G1B	0.0046
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
174	Sigma 1-type opioid receptor	SIGMAR1	0.0045
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0044
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0044
4103	Proteasome subunit beta type 2	PSMB2	0.0044
4102	Proteasome subunit beta type 5	PSMB5	0.0044
6048	Troponin C, skeletal muscle	TNNC2	0.0044
4101	Proteasome subunit beta type 1	PSMB1	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
1864	RET proto-oncogene	RET	0.0043
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0043
4217	Telomerase reverse transcriptase	TERT	0.0043
1517	Beta-3 adrenergic receptor	ADRB3	0.0043
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0043
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0043
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0043
4311	tRNA	TRDMT1	0.0043
4325	tRNA	trmD	0.0043
4328	tRNA	trmD	0.0043
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0043
3913	Glutamic acid decarboxylase	GAD65	0.0042
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0042
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
164	Histamine H4 receptor	HRH4	0.004
3937	Fatty-acid amide hydrolase	FAAH	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1313	Lactoylglutathione lyase	GLO1	0.0038
6126	Carbonic anhydrase 7	CA7	0.0038
719	Retinoic acid receptor responder protein 1	RARRES1	0.0038
770	Retinoic acid-induced protein 3	GPRC5A	0.0038
3639	Thymidine phosphorylase	deoA	0.0037
3936	Thymidine phosphorylase	TYMP	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
2782	Complement C1s subcomponent	C1S	0.0037
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0036
482	Glycine receptor subunit alpha-1	GLRA1	0.0036
340	Apoptotic protease-activating factor 1	APAF1	0.0035
3904	Alanine aminotransferase 2	GPT2	0.0035
735	Alanine aminotransferase 1	GPT	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
518	Peroxidase/catalase T	katG	0.0035
939	50S ribosomal protein L3	rplC	0.0035
5798	Mitogen-activated protein kinase 11	MAPK11	0.0035
3815	Complement C1q subcomponent subunit A	C1QA	0.0034
3816	Complement C1q subcomponent subunit B	C1QB	0.0034
3817	Complement C1q subcomponent subunit C	C1QC	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0034
2320	Thymidine kinase, cytosolic	TK1	0.0034
6042	Prostaglandin reductase 2	PTGR2	0.0034
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0034
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0034
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0034
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0034
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0034
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0034
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0034
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0034
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0034
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0034
3814	Complement C1r subcomponent	C1R	0.0034
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.0034
581	Cytochrome P450 2R1	CYP2R1	0.0034
569	Retinal dehydrogenase 2	ALDH1A2	0.0033
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0033
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0033
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
4226	Uridine phosphorylase 2	UPP2	0.0033
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0031
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0031
825	Arsenical pump-driving ATPase	ASNA1	0.0031
3435	Arsenical pump-driving ATPase	arsA	0.0031
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0031
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0031
154	AFG3-like protein 2	AFG3L2	0.0031
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0031
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0031
733	Activin receptor type 1B	ACVR1B	0.0031
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0031
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0031
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0031
395	ALK tyrosine kinase receptor	Not Available	0.0031
611	Retinal dehydrogenase 1	ALDH1A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
4225	Uridine phosphorylase 1	UPP1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
292	Activin receptor type-1	ACVR1	0.0029
849	Activated CDC42 kinase 1	TNK2	0.0028
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0028
1291	cAMP response element-binding protein	CREB1	0.0028
413	Amidophosphoribosyltransferase	PPAT	0.0028
2515	Amidophosphoribosyltransferase	purF	0.0028
3714	Amidophosphoribosyltransferase	purF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0028
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0027
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0027
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0027
297	Adenylate cyclase type 1	ADCY1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4210	Toll-like receptor 4	TLR4	0.0027
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
760	Fibroblast growth factor 1	FGF1	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
6432	Transporter	snf	0.0027
605	Fumarate reductase flavoprotein subunit	frdA	0.0027
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0027
3673	Fumarate reductase flavoprotein subunit	fccA	0.0027
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0027
6549	Fumarate reductase flavoprotein subunit	frdA	0.0027
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0026
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
3959	Cell division protein kinase 4	CDK4	0.0025
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
4041	Microsomal glutathione S-transferase 2	MGST2	0.0024
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
740	Argininosuccinate synthase	ASS1	0.0023
865	Argininosuccinate synthase	ASS1	0.0023
2680	Argininosuccinate synthase	argG	0.0023
3194	Argininosuccinate synthase	argG	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
661	ADP/ATP translocase 1	SLC25A4	0.0023
6021	Adenosine kinase	ADK	0.0023
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
1992	Vitamin D-binding protein	GC	0.0022
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0022
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0022
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0022
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.002
6459	Glycodelin	PAEP	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
1039	Histone deacetylase 9	HDAC9	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
4031	Glutathione S-transferase A1	GSTA1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0018
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0018
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
2207	Rhodopsin	RHO	0.0018
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0018
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0017
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0017
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0017
1928	Leukotriene C4 synthase	LTC4S	0.0017
4034	Glutaredoxin-1	GLRX	0.0017
910	Epididymal secretory glutathione peroxidase	GPX5	0.0017
4037	Hypothetical protein	GPX1	0.0017
4297	Hypothetical protein	SP_1951	0.0017
4521	Hypothetical protein	BC_2969	0.0017
4540	Hypothetical protein	TM_1070	0.0017
4555	Hypothetical protein	MT1739	0.0017
4569	Hypothetical protein	mshD	0.0017
4578	Hypothetical protein	PA3270	0.0017
4747	Hypothetical protein	PA3967	0.0017
5177	Hypothetical protein	TM_0096	0.0017
5194	Hypothetical protein	PA1204	0.0017
5240	Hypothetical protein	Rv2991	0.0017
5370	Hypothetical protein	TM_1158	0.0017
5710	Hypothetical protein	Tb927.5.1360	0.0017
4029	Microsomal glutathione S-transferase 3	MGST3	0.0017
4036	Glutathione peroxidase 6	GPX6	0.0017
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0017
4032	Microsomal glutathione S-transferase 1	MGST1	0.0017
903	Glutathione S-transferase A5	GSTA5	0.0017
4040	Glutathione peroxidase 7	GPX7	0.0017
907	Glutathione peroxidase 2	GPX2	0.0017
900	Glutathione S-transferase A4	GSTA4	0.0017
911	Glutathione peroxidase 3	GPX3	0.0017
906	Glutathione peroxidase 1	GPX1	0.0017
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0017
4035	Glutathione S-transferase Mu 5	GSTM5	0.0017
4042	Glutathione transferase omega-2	GSTO2	0.0017
4038	Glutathione peroxidase 4	GPX4	0.0017
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0017
4033	S-formylglutathione hydrolase	ESD	0.0017
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0016
898	Glutathione S-transferase A3	GSTA3	0.0016
897	Glutathione S-transferase kappa 1	GSTK1	0.0015
3233	Bile acid receptor	NR1H4	0.0015
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0015
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0015
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
909	Maleylacetoacetate isomerase	GSTZ1	0.0015
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0014
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
2165	Glutathione S-transferase Mu 2	GSTM2	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
207	Glutathione synthetase	GSS	0.0013
5269	Glutathione synthetase	gshB	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
901	Glutathione S-transferase Mu 4	GSTM4	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
444	Alcohol dehydrogenase 1B	ADH1B	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
3221	Cytochrome c4	cc4	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
6859	Protein S100-A4	S100A4	0.0012
707	72 kDa type IV collagenase	MMP2	0.0011
714	Glutathione reductase, mitochondrial	GSR	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
251	Alcohol dehydrogenase 1A	ADH1A	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
820	Glycine receptor subunit alpha-2	GLRA2	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
2298	Cytochrome P450-cam	camC	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
1867	Major prion protein	PRNP	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0008
1268	Neuropeptide S receptor	NPSR1	0.0008
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0008
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0007
6072	Potassium channel subfamily K member 3	KCNK3	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
1507	Cytochrome c	CYCS	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4916	Cyanoglobin	glbN	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4943	Cytochrome c6	petJ	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
5000	HemO	hemO	0.0005
4984	Neuroglobin	NGB	0.0005
4909	CooA protein	cooA	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4910	Cytoglobin	CYGB	0.0005
4961	Hemophore HasA	hasA	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4972	P450cin	cinA	0.0005
4952	Catalase/peroxidase	katA	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
2802	Endoglucanase G	celCCG	0.0004
4920	Peroxidase/catalase	katG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
358	Cystathionine beta-synthase	CBS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01229 - Paclitaxel

Targets

Enzymes

Transporters

Predictions