DT-Web

DB00441 - Gemcitabine


Identification
Name Gemcitabine
Accession Number DB00441 (APRD00201)
Type small molecule
Description Gemcitabine is a nucleoside analog used as chemotherapy. It is marketed as Gemzar(R) by Eli Lilly and Company. As with fluorouracil and other analogues of pyrimidines, the drug replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the "faulty" nucleoside, resulting in apoptosis (cellular "suicide"). Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. It is being investigated for use in oesophageal cancer, and is used experimentally in lymphomas and various other tumor types.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 263.1981
Groups approved
Monoisotopic Weight 263.071762265
Pharmacology
Indication Gemcitabine is indicated for the treatment of advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy; metastatic ovarian cancer; inoperable, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer; and locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas.
Mechanism of action Gemcitabine inhibits thymidylate synthetase, leading to inhibition of DNA synthesis and cell death. Gemcitabine is a prodrug so activity occurs as a result of intracellular conversion to two active metabolites, gemcitabine diphosphate and gemcitabine triphosphate by deoxycitidine kinase. Gemcitabine diphosphate also inhibits ribonucleotide reductase, the enzyme responsible for catalyzing synthesis of deoxynucleoside triphosphates required for DNA synthesis. Finally, Gemcitabine triphosphate (diflurorodeoxycytidine triphosphate) competes with endogenous deoxynucleoside triphosphates for incorporation into DNA.
Absorption The pharmacokinetics of gemcitabine are described by a 2-compartment model.
Protein binding Plasma protein binding is negligible (<10%)
Biotransformation Transformed via nucleoside kinases to two active metabolites, gemcitabine diphosphate and gemcitabine triphosphate. Can also undergo deamination via cytidine deaminase to an inactive uracil metabolite (dFdU).
Route of elimination Within one (1) week, 92% to 98% of the dose was recovered, almost entirely in the urine. Gemcitabine (<10%) and the inactive uracil metabolite, 2?-deoxy-2?,2?-difluorouridine (dFdU), accounted for 99% of the excreted dose.
Toxicity Myelosuppression, paresthesias, and severe rash were the principal toxicities, LD50=500 mg/kg (orally in mice and rats)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Gemcitabine may increase the anticoagulant effect of acenocoumarol.
Anisindione Gemcitabine may increase the anticoagulant effect of anisindione.
Bivalirudin Gemcitabine may enhance the adverse/toxic effect of Bleomycin. The risk of pulmonary toxicity may be increased. Use extreme caution if using gemcitabine and bleomycin in combination. Monitor for the development of pulmonary toxicity.
Dicumarol Gemcitabine may increase the anticoagulant effect of dicumarol.
Paclitaxel Paclitaxel increases the effect/toxicity of gemcitabine
Temsirolimus Co-administration of Temsirolimus and Gemcitabine may result in serious adverse drug reactions.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Warfarin Gemcitabine may increase the anticoagulant effect of warfarin.
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions cross-linking/alkylation
References
  • Hastak K, Alli E, Ford JM: Synergistic chemosensitivity of triple-negative breast cancer cell lines to PARP inhibition, gemcitabine and cisplatin. Cancer Res. 2010 Aug 26. - Pubmed
  • Ledermann JA, Gabra H, Jayson GC, Spanswick VJ, Rustin GJ, Jitlal M, James L, Hartley JA: Inhibition of carboplatin-induced DNA interstrand crosslink repair by gemcitabine in patients receiving these drugs for 'platinum-resistant' ovarian cancer. Clin Cancer Res. 2010 Aug 18. - Pubmed
  • Garcia-Diaz M, Murray MS, Kunkel TA, Chou KM: Interaction between DNA Polymerase lambda and anticancer nucleoside analogs. J Biol Chem. 2010 May 28;285(22):16874-9. Epub 2010 Mar 26. - Pubmed
DTHybrid score Not Available
Ribonucleoside-diphosphate reductase large subunit
Name Ribonucleoside-diphosphate reductase large subunit
Gene Name RRM1
Pharmacological action yes
Actions inhibitor
References
  • Kwon WS, Rha SY, Choi YH, Lee JO, Park KH, Jung JJ, Kim TS, Jeung HC, Chung HC: Ribonucleotide reductase M1 (RRM1) 2464G>A polymorphism shows an association with gemcitabine chemosensitivity in cancer cell lines. Pharmacogenet Genomics. 2006 Jun;16(6):429-38. - Pubmed
  • Rosell R, Cobo M, Isla D, Camps C, Massuti B: Pharmacogenomics and gemcitabine. Ann Oncol. 2006 May;17 Suppl 5:v13-v16. - Pubmed
  • Bepler G, Kusmartseva I, Sharma S, Gautam A, Cantor A, Sharma A, Simon G: RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer. J Clin Oncol. 2006 Oct 10;24(29):4731-7. Epub 2006 Sep 11. - Pubmed
  • Smid K, Bergman AM, Eijk PP, Veerman G, van Haperen VW, van den Ijssel P, Ylstra B, Peters GJ: Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits. Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1001-7. - Pubmed
  • Nakahira S, Nakamori S, Tsujie M, Takahashi Y, Okami J, Yoshioka S, Yamasaki M, Marubashi S, Takemasa I, Miyamoto A, Takeda Y, Nagano H, Dono K, Umeshita K, Sakon M, Monden M: Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. Int J Cancer. 2007 Mar 15;120(6):1355-63. - Pubmed
  • Cerqueira NM, Fernandes PA, Ramos MJ: Understanding ribonucleotide reductase inactivation by gemcitabine. Chemistry. 2007;13(30):8507-15. - Pubmed
DTHybrid score 0.6434
Thymidylate synthase
Name Thymidylate synthase
Gene Name TYMS
Pharmacological action unknown
Actions inhibitor
References
  • Rosell R, Taron M, Sanchez JM, Moran T, Reguart N, Besse B, Isla D, Massuti B, Alberola V, Sanchez JJ: The promise of pharmacogenomics: gemcitabine and pemetrexed. Oncology (Williston Park). 2004 Nov;18(13 Suppl 8):70-6. - Pubmed
  • Huang CL, Yokomise H, Fukushima M, Kinoshita M: Tailor-made chemotherapy for non-small cell lung cancer patients. Future Oncol. 2006 Apr;2(2):289-99. - Pubmed
  • Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, Marini L, Del Tacca M, Danesi R: Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. Mol Pharmacol. 2005 Jul;68(1):110-8. Epub 2005 Mar 28. - Pubmed
  • Zhao XD, Zhang Y: [Routine chemotherapeutic drug treatment effectiveness predictive molecules and chemotherapeutic drug selection] Ai Zheng. 2006 Dec;25(12):1577-80. - Pubmed
  • Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, Del Tacca M, Danesi R: Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer. Mol Cancer Ther. 2006 Jun;5(6):1387-95. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Marce S, Molina-Arcas M, Villamor N, Casado FJ, Campo E, Pastor-Anglada M, Colomer D: Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma. Haematologica. 2006 Jul;91(7):895-902. - Pubmed
  • Marce S, Molina-Arcas M, Villamor N, Casado FJ, Campo E, Pastor-Anglada M, Colomer D: Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma. Haematologica. 2006 Jul;91(7):895-902. - Pubmed
  • Marce S, Molina-Arcas M, Villamor N, Casado FJ, Campo E, Pastor-Anglada M, Colomer D: Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma. Haematologica. 2006 Jul;91(7):895-902. - Pubmed
  • Marce S, Molina-Arcas M, Villamor N, Casado FJ, Campo E, Pastor-Anglada M, Colomer D: Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma. Haematologica. 2006 Jul;91(7):895-902. - Pubmed
  • Marce S, Molina-Arcas M, Villamor N, Casado FJ, Campo E, Pastor-Anglada M, Colomer D: Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma. Haematologica. 2006 Jul;91(7):895-902. - Pubmed
DTHybrid score 0.7498
UMP-CMP kinase
Name UMP-CMP kinase
Gene Name CMPK1
Pharmacological action unknown
Actions inhibitor
References
  • Vernejoul F, Ghenassia L, Souque A, Lulka H, Drocourt D, Cordelier P, Pradayrol L, Pyronnet S, Buscail L, Tiraby G: Gene therapy based on gemcitabine chemosensitization suppresses pancreatic tumor growth. Mol Ther. 2006 Dec;14(6):758-67. Epub 2006 Sep 25. - Pubmed
  • Hsu CH, Liou JY, Dutschman GE, Cheng YC: Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium. Mol Pharmacol. 2005 Mar;67(3):806-14. Epub 2004 Nov 18. - Pubmed
  • Maring JG, Groen HJ, Wachters FM, Uges DR, de Vries EG: Genetic factors influencing pyrimidine-antagonist chemotherapy. Pharmacogenomics J. 2005;5(4):226-43. - Pubmed
  • Lam W, Leung CH, Bussom S, Cheng YC: The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine. Mol Pharmacol. 2007 Sep;72(3):536-44. Epub 2007 Jun 12. - Pubmed
DTHybrid score 0.5347

Enzymes


Cytidine deaminase
Name Cytidine deaminase
Gene Name CDA
Actions substrate
References
  • Giovannetti E, Laan AC, Vasile E, Tibaldi C, Nannizzi S, Ricciardi S, Falcone A, Danesi R, Peters GJ: Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):720-5. - Pubmed
  • Gusella M, Pasini F, Bolzonella C, Meneghetti S, Barile C, Bononi A, Toso S, Menon D, Crepaldi G, Modena Y, Stievano L, Padrini R: Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours. Br J Clin Pharmacol. 2011 Mar;71(3):437-44. doi: 10.1111/j.1365-2125.2010.03838.x. - Pubmed
  • Wong A, Soo RA, Yong WP, Innocenti F: Clinical pharmacology and pharmacogenetics of gemcitabine. Drug Metab Rev. 2009;41(2):77-88. - Pubmed
DTHybrid score 0.8295
Deoxycytidine kinase
Name Deoxycytidine kinase
Gene Name DCK
Actions substrate
References
  • Wong A, Soo RA, Yong WP, Innocenti F: Clinical pharmacology and pharmacogenetics of gemcitabine. Drug Metab Rev. 2009;41(2):77-88. - Pubmed
  • Marechal R, Mackey JR, Lai R, Demetter P, Peeters M, Polus M, Cass CE, Salmon I, Deviere J, Van Laethem JL: Deoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma. Cancer. 2010 Nov 15;116(22):5200-6. doi: 10.1002/cncr.25303. - Pubmed
DTHybrid score 0.8547

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Bergman AM, Pinedo HM, Talianidis I, Veerman G, Loves WJ, van der Wilt CL, Peters GJ: Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines. Br J Cancer. 2003 Jun 16;88(12):1963-70. - Pubmed
DTHybrid score 0.2927
Multidrug resistance-associated protein 7
Name Multidrug resistance-associated protein 7
Gene Name ABCC10
Actions substrate
References
  • Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD: Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res. 2009 Jan 1;69(1):178-84. - Pubmed
DTHybrid score 0.2326
Equilibrative nucleoside transporter 1
Name Equilibrative nucleoside transporter 1
Gene Name SLC29A1
Actions substrate
References
  • Santini D, Vincenzi B, Fratto ME, Perrone G, Lai R, Catalano V, Cass C, Ruffini PA, Spoto C, Muretto P, Rizzo S, Muda AO, Mackey JR, Russo A, Tonini G, Graziano F: Prognostic role of human equilibrative transporter 1 (hENT1) in patients with resected gastric cancer. J Cell Physiol. 2010 May;223(2):384-8. - Pubmed
  • Marce, S. et al. Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma. Haematologica 91, 895-902 (2006). - Pubmed
DTHybrid score 0.5984
Sodium/nucleoside cotransporter 1
Name Sodium/nucleoside cotransporter 1
Gene Name Not Available
Actions Not Available
References
  • Mackey JR, Yao SY, Smith KM, Karpinski E, Baldwin SA, Cass CE, Young JD: Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. J Natl Cancer Inst. 1999 Nov 3;91(21):1876-81. - Pubmed
DTHybrid score Not Available
Equilibrative nucleoside transporter 2
Name Equilibrative nucleoside transporter 2
Gene Name Not Available
Actions Not Available
References
  • Mackey JR, Yao SY, Smith KM, Karpinski E, Baldwin SA, Cass CE, Young JD: Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. J Natl Cancer Inst. 1999 Nov 3;91(21):1876-81. - Pubmed
DTHybrid score Not Available
Solute carrier family 28 member 3
Name Solute carrier family 28 member 3
Gene Name SLC28A3
Actions substrate
References
  • Govindarajan R, Leung GP, Zhou M, Tse CM, Wang J, Unadkat JD: Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G910-22. doi: 10.1152/ajpgi.90672.2008. Epub 2009 Jan 22. - Pubmed
DTHybrid score 0.4888

Predictions


Id Partner name Gene Name Score
3611 Cytidine deaminase cdd 0.8295
3707 Cytidine deaminase cdd 0.8295
24 Thymidylate synthase TMP1 0.7498
2626 Thymidylate synthase thyA 0.7498
2729 Thymidylate synthase thyA 0.7498
5352 Thymidylate synthase THYA 0.7498
603 DNA polymerase alpha catalytic subunit POLA1 0.3514
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.1973
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1377
4512 Cytochrome P450 3A4 CYP3A4 0.1284
3639 Thymidine phosphorylase deoA 0.1274
3936 Thymidine phosphorylase TYMP 0.1274
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.1165
4119 Cytochrome P450 2D6 CYP2D6 0.0991
3690 Class B acid phosphatase precursor aphA 0.0952
6145 Solute carrier family 22 member 1 SLC22A1 0.0939
6144 Solute carrier family 22 member 2 SLC22A2 0.082
1830 5'-nucleotidase NT5E 0.0805
4757 Cytochrome P450 2C9 CYP2C9 0.0801
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0779
125 DNA polymerase beta POLB 0.0764
2164 Multidrug resistance-associated protein 4 ABCC4 0.0762
365 Dihydrofolate reductase DHFR 0.0748
2381 Dihydrofolate reductase DFR1 0.0748
2833 Dihydrofolate reductase Not Available 0.0748
2931 Dihydrofolate reductase folA 0.0748
3544 Dihydrofolate reductase folA 0.0748
3682 Dihydrofolate reductase folA 0.0748
6642 Dihydrofolate reductase folA 0.0748
6756 Dihydrofolate reductase dfrA 0.0748
1729 Solute carrier family 22 member 6 SLC22A6 0.0736
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0734
4118 Cytochrome P450 3A5 CYP3A5 0.0704
6021 Adenosine kinase ADK 0.0692
6112 DNA polymerase epsilon subunit 3 POLE3 0.0635
6111 DNA polymerase epsilon subunit 4 POLE4 0.0634
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0634
6110 DNA polymerase epsilon subunit 2 POLE2 0.0634
277 Purine nucleoside phosphorylase PNP 0.0633
2870 Purine nucleoside phosphorylase punA 0.0633
2945 Purine nucleoside phosphorylase punA 0.0633
4659 Purine nucleoside phosphorylase TM_1596 0.0633
4825 Purine nucleoside phosphorylase TTHA1435 0.0633
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0633
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0615
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0614
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0595
311 RNA-directed RNA polymerase catalytic subunit PB1 0.0576
752 Large structural protein L 0.0576
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0562
862 Multidrug resistance-associated protein 1 ABCC1 0.0553
6107 Cytochrome P450 3A7 CYP3A7 0.0548
4924 Cytochrome P450 2C8 CYP2C8 0.051
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0502
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0479
6083 Deoxyguanosine kinase, mitochondrial DGUOK 0.0461
508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 0.0447
4200 Cytochrome P450 1A2 CYP1A2 0.0445
3957 Adenosine deaminase ADA 0.0437
4604 Liver carboxylesterase 1 CES1 0.0432
6136 Multidrug resistance-associated protein 5 ABCC5 0.0421
3669 Ribokinase rbsK 0.0398
2892 Acetylglutamate kinase argB 0.0394
3550 Acetylglutamate kinase argB 0.0394
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0389
3779 Alpha-2,3/8-sialyltransferase cst-II 0.0381
6016 Cytochrome P450 2C19 CYP2C19 0.0379
6142 Solute carrier family 22 member 8 SLC22A8 0.0375
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0374
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0369
6143 Solute carrier family 22 member 7 SLC22A7 0.0353
390 Adenosine A3 receptor ADORA3 0.0339
5626 Nucleoside diphosphate kinase B NME2 0.0338
3692 Coenzyme A biosynthesis bifunctional protein coaBC coaBC 0.0329
2251 Thymidylate kinase tmk 0.0328
2254 Thymidylate kinase DTYMK 0.0328
3522 Thymidylate kinase tmk 0.0328
6395 Myosin-14 MYH14 0.0327
776 Bile salt export pump ABCB11 0.0326
268 Adenosine A2b receptor ADORA2B 0.0323
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0322
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0322
3188 IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase ispDF 0.0319
3947 Xanthine dehydrogenase/oxidase XDH 0.0319
509 Thymidine kinase TK 0.0316
570 Thymidine kinase TK 0.0316
2559 Thymidine kinase TK 0.0316
3430 Thymidine kinase tdk 0.0316
3518 Thymidine kinase TK 0.0316
5301 Thymidine kinase tdk 0.0316
5771 Thymidine kinase ORF36 0.0316
7009 Thymidine kinase ORF36 0.0316
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0313
6020 Aldehyde oxidase AOX1 0.0311
2555 Pol polyprotein pol 0.0305
3242 Pol polyprotein gag-pol 0.0305
3471 Pol polyprotein gag-pro-pol 0.0305
5256 Pol polyprotein pol 0.0305
6469 Pol polyprotein gag-pol 0.0305
6565 Pol polyprotein Not Available 0.0305
5294 Nucleoside diphosphate kinase A NME1 0.0302
1405 Thiopurine S-methyltransferase TPMT 0.03
2697 Uridine-cytidine kinase 2 UCK2 0.0299
2909 Cytidylate kinase cmk 0.0289
3523 Spore coat polysaccharide biosynthesis protein spsA spsA 0.0281
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0281
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0281
2765 3-deoxy-manno-octulosonate cytidylyltransferase kpsU 0.027
3120 3-deoxy-manno-octulosonate cytidylyltransferase kdsB 0.027
587 Serum albumin ALB 0.0267
342 P protein [Includes: DNA-directed DNA polymerase P 0.0264
612 P protein [Includes: DNA-directed DNA polymerase P 0.0264
6024 Cytochrome P450 1A1 CYP1A1 0.0262
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
4482 UDP-galactose 4-epimerase galE 0.0253
1178 Adenosine A2a receptor ADORA2A 0.025
3524 DNA beta-glucosyltransferase bgt 0.0243
3408 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 B3GAT3 0.0242
2608 UDP-N-acetylglucosamine 2-epimerase wecB 0.0242
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0242
16 Adenosine A1 receptor ADORA1 0.0241
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0238
2291 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 B3GAT1 0.0237
6030 Cytochrome P450 2B6 CYP2B6 0.0237
2320 Thymidine kinase, cytosolic TK1 0.0236
6147 Solute carrier family 22 member 3 SLC22A3 0.0234
2590 Galactose-1-phosphate uridylyltransferase galT 0.0225
1898 Cytochrome P450 1B1 CYP1B1 0.0218
2257 Uridine phosphorylase udp 0.0215
5132 Uridine phosphorylase udp 0.0215
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.0209
6031 Cytochrome P450 3A43 CYP3A43 0.0205
2762 UDP-glucose 4-epimerase GALE 0.019
3461 UDP-glucose 4-epimerase galE 0.019
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.018
6013 Cytochrome P450 2E1 CYP2E1 0.0177
817 DNA topoisomerase 2-alpha TOP2A 0.0165
237 Histo-blood group ABO system transferase ABO 0.0163
6137 Multidrug resistance-associated protein 6 ABCC6 0.0161
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0157
4226 Uridine phosphorylase 2 UPP2 0.0155
5718 Cytochrome P450 2A6 CYP2A6 0.0154
3917 Methylenetetrahydrofolate reductase MTHFR 0.0146
4225 Uridine phosphorylase 1 UPP1 0.0144
1852 Microtubule-associated protein 2 MAP2 0.0141
5923 Microtubule-associated protein tau MAPT 0.0137
5924 Microtubule-associated protein 4 MAP4 0.0137
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0131
2567 Thymidylate synthase thyX thyX 0.0128
413 Amidophosphoribosyltransferase PPAT 0.0128
2515 Amidophosphoribosyltransferase purF 0.0128
3714 Amidophosphoribosyltransferase purF 0.0128
4275 PCZA361.16 Not Available 0.0128
4276 DNA polymerase III subunit epsilon dnaQ 0.0128
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
29 Tubulin beta-1 chain TUBB1 0.0122
273 Apoptosis regulator Bcl-2 BCL2 0.0121
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0121
3811 Cytochrome P450 19A1 CYP19A1 0.012
4120 NADPH--cytochrome P450 reductase POR 0.0117
4192 DNA topoisomerase 2-beta TOP2B 0.0112
556 Alpha-1A adrenergic receptor ADRA1A 0.0108
824 Sodium-dependent serotonin transporter SLC6A4 0.0106
161 Tubulin beta chain TUBB 0.0104
312 Tubulin beta chain TUB2 0.0104
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0104
6141 Sodium/bile acid cotransporter SLC10A1 0.0103
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0102
871 Glucocorticoid receptor NR3C1 0.0099
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0098
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0098
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0096
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0094
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0093
193 Beta-1 adrenergic receptor ADRB1 0.0093
136 Estrogen receptor ESR1 0.0091
540 Sodium-dependent noradrenaline transporter SLC6A2 0.009
738 Monocarboxylate transporter 1 SLC16A1 0.0089
1024 Solute carrier family 22 member 11 SLC22A11 0.0088
831 D(2) dopamine receptor DRD2 0.0087
2539 Tubulin alpha-1 chain TUBA4A 0.0087
3923 Cholinesterase BCHE 0.0087
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0084
3361 Serpin B5 SERPINB5 0.0084
5694 Transcription antiterminator licT licT 0.0084
5818 Folate receptor alpha FOLR1 0.0083
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0082
492 Histamine H1 receptor HRH1 0.0081
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.008
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.008
20 Prostaglandin G/H synthase 1 PTGS1 0.0079
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0078
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0078
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0075
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0073
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0072
293 Gamma-glutamyl hydrolase GGH 0.0072
290 Prostaglandin G/H synthase 2 PTGS2 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.007
766 Beta-2 adrenergic receptor ADRB2 0.007
118 Organic cation/carnitine transporter 2 SLC22A5 0.0069
267 Plasminogen activator inhibitor 1 SERPINE1 0.0067
56 Delta-aminolevulinic acid dehydratase ALAD 0.0067
2356 Delta-aminolevulinic acid dehydratase hemB 0.0067
3613 Delta-aminolevulinic acid dehydratase hemB 0.0067
3674 Delta-aminolevulinic acid dehydratase hemB 0.0067
6106 Cytochrome P450 2C18 CYP2C18 0.0066
502 5-hydroxytryptamine 2A receptor HTR2A 0.0065
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0064
1650 Heme carrier protein 1 SLC46A1 0.0064
2286 Isocitrate dehydrogenase [NADP] icd 0.0063
2302 Isocitrate dehydrogenase [NADP] icd 0.0063
2771 Isocitrate dehydrogenase [NADP] icd 0.0063
869 Estrogen receptor beta ESR2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
504 Mast/stem cell growth factor receptor KIT 0.0063
4534 Cytohesin-2 CYTH2 0.0061
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.006
3868 Calcineurin subunit B isoform 2 PPP3R2 0.006
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0059
6221 Steroid hormone receptor ERR1 ESRRA 0.0059
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0059
3668 Maltose-binding periplasmic protein precursor malE 0.0059
632 Alpha-1B adrenergic receptor ADRA1B 0.0058
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0057
5300 Antigen peptide transporter 1 TAP1 0.0055
756 Sex hormone-binding globulin SHBG 0.0055
1192 Sulfotransferase 1A1 SULT1A1 0.0055
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0055
5287 Signaling protein Not Available 0.0055
5304 UPF0166 protein TM_0021 TM_0021 0.0055
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0055
3199 Phosphopantetheine adenylyltransferase coaD 0.0055
3543 Phosphopantetheine adenylyltransferase coaD 0.0055
3567 Phosphopantetheine adenylyltransferase coaD 0.0055
5289 Phosphopantetheine adenylyltransferase coaD 0.0055
5288 Shikimate kinase aroK 0.0055
5292 Putative partitioning protein TT_C1605 0.0055
2874 Nitrogenase iron protein 1 nifH1 0.0055
5293 Shikimate kinase 2 aroL 0.0055
5281 Plasmid segregation protein parM parM 0.0055
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0055
5283 D-alanine--D-alanine ligase B ddlB 0.0055
5259 Transcriptional regulator ntrC1 0.0055
6699 Transcriptional regulator Cgl2612 0.0055
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0055
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0055
5276 Chromosomal replication initiator protein dnaA dnaA 0.0055
4346 Polynucleotide kinase pseT 0.0055
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0055
5315 Chaperone protein htpG htpG 0.0055
5266 Activator of hgdC 0.0055
5284 Large T antigen Not Available 0.0055
5299 D-alanine--D-alanine ligase ddl 0.0055
6598 D-alanine--D-alanine ligase ddl 0.0055
5291 Glycogen synthase 1 glgA1 0.0055
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0055
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0055
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0055
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0055
5308 Preprotein translocase secA 1 subunit secA1 0.0055
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0055
5261 Phosphoribosylformylglycinamidine synthase purL 0.0055
5277 Preprotein translocase subunit secA secA 0.0055
5264 DNA replication protein REP 0.0055
5285 Kinesin heavy chain KIF5B 0.0055
3809 Estrogen-related receptor gamma ESRRG 0.0054
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0054
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0054
908 Glutathione S-transferase theta-1 GSTT1 0.0053
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0053
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0053
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0053
2592 Beta-galactosidase lacZ 0.0053
6182 Cytochrome P450 2J2 CYP2J2 0.0052
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0052
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0052
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0052
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0051
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0051
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0051
320 5-hydroxytryptamine 1A receptor HTR1A 0.005
789 Alpha-1D adrenergic receptor ADRA1D 0.005
844 Epidermal growth factor receptor EGFR 0.005
315 Arginase-1 ARG1 0.005
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.005
731 HIV-1 protease HIV-1 protease 0.005
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0049
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0049
904 Glutathione S-transferase P GSTP1 0.0049
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0049
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0049
6167 Organic solute transporter subunit beta OSTB 0.0049
6166 Organic solute transporter subunit alpha OSTA 0.0049
23 D(1A) dopamine receptor DRD1 0.0048
847 Mu-type opioid receptor OPRM1 0.0048
833 Organic cation/carnitine transporter 1 SLC22A4 0.0048
6085 Fatty acid-binding protein, intestinal FABP2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0047
3587 Gastrotropin FABP6 0.0046
465 Calmodulin CALM1 0.0046
340 Apoptotic protease-activating factor 1 APAF1 0.0046
318 Alpha-2A adrenergic receptor ADRA2A 0.0045
4106 Guanylate kinase GUK1 0.0045
4516 Guanylate kinase gmk 0.0045
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0045
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0045
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0045
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0045
6277 Heat shock cognate 71 kDa protein HSPA8 0.0044
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0044
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0044
4837 Cag-alfa cag-alfa 0.0044
5302 TrwB trwB 0.0044
5646 Galactokinase GALK1 0.0044
4774 NTPase P4 Not Available 0.0044
5265 FtsH ftsH 0.0044
4839 DNA polymerase III subunit tau dnaX 0.0044
4838 PMS1 protein homolog 2 PMS2 0.0044
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0044
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0044
124 Histamine H2 receptor HRH2 0.0044
2284 Adenylate kinase adk 0.0044
2296 Adenylate kinase adk 0.0044
2311 Adenylate kinase adk 0.0044
2312 Adenylate kinase Not Available 0.0044
2270 Dephospho-CoA kinase coaE 0.0044
5189 Trimethylamine dehydrogenase tmd 0.0044
6168 Solute carrier family 22 member 16 SLC22A16 0.0044
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0043
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0043
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0043
467 Delta-type opioid receptor OPRD1 0.0043
3470 Hypothetical protein MG245 homolog MPN_348 0.0043
260 Cytochrome P450 51 ERG11 0.0043
761 Cytochrome P450 51 ERG11 0.0043
3163 Cytochrome P450 51 cyp51 0.0043
3175 Glutamate--cysteine ligase gshA 0.0043
3426 Glutamine synthetase glnA 0.0043
3987 Glutamine synthetase GLUL 0.0043
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0042
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0041
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0041
2683 Mono-ADP-ribosyltransferase C3 C3 0.0041
614 Progesterone receptor PGR 0.0041
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.004
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
2390 Nonsecretory ribonuclease RNASE2 0.004
220 Sodium channel protein type 5 subunit alpha SCN5A 0.004
5312 Kinesin-like protein KIF1A KIF1A 0.004
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.004
5251 Carbonyl reductase [NADPH] 1 CBR1 0.004
696 Kappa-type opioid receptor OPRK1 0.004
474 Acetylcholinesterase ACHE 0.004
2922 Glycerol kinase glpK 0.0039
5271 Focal adhesion kinase 1 PTK2 0.0039
2282 Protein recA recA 0.0039
2315 Protein recA recA 0.0039
2332 Protein recA recA 0.0039
5263 Protein recA recA 0.0039
885 5-hydroxytryptamine 1B receptor HTR1B 0.0038
725 5-hydroxytryptamine 1D receptor HTR1D 0.0038
408 Riboflavin kinase RFK 0.0038
2615 Chemotaxis protein cheA cheA 0.0037
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0037
1881 Hexokinase-1 HK1 0.0037
952 Dipeptidyl peptidase 4 DPP4 0.0037
2371 Pantothenate kinase coaA 0.0036
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0035
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0035
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
33 Cystine/glutamate transporter SLC7A11 0.0035
2727 S-adenosylmethionine synthetase metK 0.0034
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
788 Creatine kinase M-type CKM 0.0033
3941 Amine oxidase [flavin-containing] A MAOA 0.0033
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0033
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0033
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0032
3939 Amine oxidase [flavin-containing] B MAOB 0.0032
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0032
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0032
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0032
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0032
2334 Dethiobiotin synthetase bioD 0.0032
6555 Dethiobiotin synthetase bioD 0.0032
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0032
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0032
2499 Tubulin beta-2C chain TUBB2C 0.0031
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0031
48 Pyridoxal kinase PDXK 0.0031
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0031
638 D(3) dopamine receptor DRD3 0.0031
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
590 5-hydroxytryptamine 2C receptor HTR2C 0.003
1721 Glycogen synthase kinase-3 beta GSK3B 0.003
2091 Endoplasmin HSP90B1 0.003
7 Nitric oxide synthase, inducible NOS2 0.003
26 Vascular endothelial growth factor receptor 3 FLT4 0.0029
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
207 Glutathione synthetase GSS 0.0029
5269 Glutathione synthetase gshB 0.0029
380 Cytochrome P450 17A1 CYP17A1 0.0029
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0029
683 Potassium transporter GK0582 0.0029
70 Type-1 angiotensin II receptor AGTR1 0.0029
629 Alpha-2B adrenergic receptor ADRA2B 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
32 Vascular endothelial growth factor receptor 1 FLT1 0.0028
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0028
1422 Serine/threonine-protein kinase 6 AURKA 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
76 Nitric-oxide synthase, brain NOS1 0.0028
737 Mineralocorticoid receptor NR3C2 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
3379 Kinesin-like protein KIF11 KIF11 0.0027
777 Tumor necrosis factor TNF 0.0027
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0027
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0027
3822 Actin, alpha skeletal muscle ACTA1 0.0027
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0027
291 Nitric-oxide synthase, endothelial NOS3 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0026
407 Vascular endothelial growth factor receptor 2 KDR 0.0026
228 Beta platelet-derived growth factor receptor PDGFRB 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
146 Androgen receptor AR 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
5682 Ribonuclease pancreatic RNASE1 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0023
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0023
713 Sodium-dependent dopamine transporter SLC6A3 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
373 Transthyretin TTR 0.0023
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0022
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
468 Cytochrome P450 4A11 CYP4A11 0.0021
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0021
378 Alpha-2C adrenergic receptor ADRA2C 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
1656 CYP2B protein CYP2B 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0018
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0018
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0018
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0018
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0017
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
6755 Poliovirus receptor PVR 0.0015
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
165 FL cytokine receptor FLT3 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0015
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
1629 Transcription factor AP-1 JUN 0.0014
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0014
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0013
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
6432 Transporter snf 0.0013
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0012
694 Matrix protein 2 M 0.0012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0012
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
432 D(4) dopamine receptor DRD4 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0011
469 Annexin A1 ANXA1 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
1618 High affinity nerve growth factor receptor NTRK1 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
427 Substance-P receptor TACR1 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
4203 Histamine N-methyltransferase HNMT 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
811 Translocator protein TSPO 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
936 Ephrin type-A receptor 2 EPHA2 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
54 Prothrombin F2 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
5787 Angiopoietin-1 receptor TEK 0.0008
823 Fibroblast growth factor receptor 2 FGFR2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
163 D(1B) dopamine receptor DRD5 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0006
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0006
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
341 5-hydroxytryptamine 3 receptor HTR3A 0.0006
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0006
2981 Phospholipase A2, membrane associated PLA2G2A 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2021 Thrombomodulin THBD 0.0005
2207 Rhodopsin RHO 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
572 Integrin alpha-L ITGAL 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
4122 Histone deacetylase 2 HDAC2 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
6102 Arylamine N-acetyltransferase 2 NAT2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6218 Pannexin-1 PANX1 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6220 Aryl hydrocarbon receptor AHR 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
2802 Endoglucanase G celCCG 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6043 Putative G-protein coupled receptor 44 GPR44 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6014 Cytochrome P450 2A13 CYP2A13 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
295 Carbonic anhydrase 1 CA1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
1757 Myeloperoxidase MPO 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
275 Arachidonate 5-lipoxygenase ALOX5 0.0003
164 Histamine H4 receptor HRH4 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
517 Alcohol dehydrogenase 1C ADH1C 0.0002
921 Glutamate receptor 2 GRIA2 0.0002
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