DT-Web: DB05812

Identification

Name

Abiraterone

Accession Number

DB05812

Type

small molecule

Description

Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antineoplastic Agents

Molecular Weight

391.5457

Groups

approved

Monoisotopic Weight

391.251129305

Pharmacology

Indication

Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.

Mechanism of action

Abiraterone is an orally active inhibitor of the steroidal enzyme CYP17A1 (17 alpha-hydroxylase/C17,20 lyase). It inhibits CYP17A1 in a selective and irreversible manner via covalent binding mechanism. CYP17A1 is an enzyme that catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. More specifically, abiraterone inhibits the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to decrease serum levels of testosterone and other androgens.

Absorption

Abiraterone itself is poorly absorbed and is susceptible to hydrolysis by esterases. The salt form, abiraterone acetate, is a prodrug which has a much higher oral bioavailability and is also esterase resistant. Peak drug concentrations of abiraterone were reached in 1.5 - 4 hours. Abiraterone acetate was rapidly and completely deacetylated into abiraterone-the parent salt form was not detectable in early pharmacokinetic studies. Food and high fat meals increases absorption 4.4-fold.

Protein binding

>99% protein bound to alpha-1-acid glycoprotein and albumin.

Biotransformation

Abiraterone acetate is hydrolyzed into active metabolite abiraterone via esterases. CYP3A4 and SULT2A1 further metabolizes abiraterone into two inactive metabolites called abiraterone sulfate and N-oxide abiraterone sulfate.

Route of elimination

Excreted via feces (~88%) and urine (~5%)

Toxicity

Toxicity is related to the blockade of 17?-hydroxylase activity. Blockade results in the accumulation of upstream mineralocorticoids like 11-deoxycorticosterone leading to secondary hyperaldosteronism. Signs of hydroaldosteronism include fluid retention and hypokalemia. Mineralocorticoid receptor antagonists may be used to treat signs and symptoms.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Bosutinib	Abiraterone increases levels by P-glycoprotein (MDR1) efflux transporter. Consider alternate therapy.
Carbamazepine	Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Clarithromycin	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Dextromethorphan	Abiraterone increases levels by affecting CYP2D6 metabolism. Interaction is significant so monitor closely.
Indinavir	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Itraconazole	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Ketoconazole	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Nefazodone	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Nelfinavir	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Phenobarbital	Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Phenytoin	Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Rifabutin	Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Rifampin	Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Rifapentine	Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Ritonavir	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Saquinavir	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Telithromycin	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Thioridazine	Abiraterone increases levels by affecting CYP2D6 metabolism. Interaction is significant so monitor closely.
Voriconazole	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.

Food Interactions

Food and high fat meals increases the drug exposure 4.4-fold. It is suggested that abiraterone is taken on an empty stomach.

Cytochrome P450 17A1
Name	Cytochrome P450 17A1
Gene Name	CYP17A1
Pharmacological action	yes
Actions	inhibitor
References	Vogiatzi P, Claudio PP: Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer. Expert Rev Anticancer Ther. 2010 Jul;10(7):1027-30. - Pubmed
DTHybrid score	0.1896

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Beckett RD, Rodeffer KM, Snodgrass R: Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. doi: 10.1345/aph.1Q758. Epub 2012 Jun 19. - Pubmed
DTHybrid score	0.5542
Bile salt sulfotransferase
Name	Bile salt sulfotransferase
Gene Name	SULT2A1
Actions	substrate
References	Beckett RD, Rodeffer KM, Snodgrass R: Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. doi: 10.1345/aph.1Q758. Epub 2012 Jun 19. - Pubmed
DTHybrid score	0.5391
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Chi KN, Tolcher A, Lee P, Rosen PJ, Kollmannsberger CK, Papadopoulos KP, Patnaik A, Molina A, Jiao J, Pankras C, Kaiser B, Bernard A, Tran N, Acharya M: Effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan and theophylline in patients with metastatic castration-resistant prostate cancer. Cancer Chemother Pharmacol. 2013 Jan;71(1):237-44. doi: 10.1007/s00280-012-2001-0. Epub 2012 Oct 12. - Pubmed
DTHybrid score	0.4356
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	FDA label -
DTHybrid score	0.3014

Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Beckett RD, Rodeffer KM, Snodgrass R: Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. doi: 10.1345/aph.1Q758. Epub 2012 Jun 19. - Pubmed
DTHybrid score	0.2145

Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions
References	Not Available
DTHybrid score	0.2145

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.2647
1588	Multidrug resistance protein 1	ABCB1	0.2629
6016	Cytochrome P450 2C19	CYP2C19	0.2015
4200	Cytochrome P450 1A2	CYP1A2	0.1828
4118	Cytochrome P450 3A5	CYP3A5	0.1683
6107	Cytochrome P450 3A7	CYP3A7	0.1439
6030	Cytochrome P450 2B6	CYP2B6	0.1169
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1031
6013	Cytochrome P450 2E1	CYP2E1	0.1002
4824	Dehydrogenase/reductase SDR family member 8	HSD17B11	0.0948
2831	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	Not Available	0.0854
3059	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	fabG3	0.0854
6024	Cytochrome P450 1A1	CYP1A1	0.085
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0775
1729	Solute carrier family 22 member 6	SLC22A6	0.0747
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0745
20	Prostaglandin G/H synthase 1	PTGS1	0.0718
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0686
5718	Cytochrome P450 2A6	CYP2A6	0.0684
6307	Ig gamma-2 chain C region	IGHG2	0.0605
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0587
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0573
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0546
492	Histamine H1 receptor	HRH1	0.0538
831	D(2) dopamine receptor	DRD2	0.0519
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0512
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0512
556	Alpha-1A adrenergic receptor	ADRA1A	0.0511
824	Sodium-dependent serotonin transporter	SLC6A4	0.0508
6106	Cytochrome P450 2C18	CYP2C18	0.0499
6145	Solute carrier family 22 member 1	SLC22A1	0.0493
290	Prostaglandin G/H synthase 2	PTGS2	0.0487
2268	Cholesterol oxidase	choB	0.0481
2822	Cholesterol oxidase	choA	0.0481
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0477
118	Organic cation/carnitine transporter 2	SLC22A5	0.0465
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0461
776	Bile salt export pump	ABCB11	0.0457
2283	Steroid Delta-isomerase	ksi	0.0446
2920	Steroid Delta-isomerase	ksi	0.0446
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0442
3811	Cytochrome P450 19A1	CYP19A1	0.0437
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0434
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0425
1898	Cytochrome P450 1B1	CYP1B1	0.0423
6144	Solute carrier family 22 member 2	SLC22A2	0.0406
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0393
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0384
2164	Multidrug resistance-associated protein 4	ABCC4	0.0382
1192	Sulfotransferase 1A1	SULT1A1	0.0378
6142	Solute carrier family 22 member 8	SLC22A8	0.0367
1275	Estrogen sulfotransferase	SULT1E1	0.0361
4382	Sulfotransferase family cytosolic 1B member 1	SULT1B1	0.0345
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0344
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0344
4380	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	NDST1	0.0344
766	Beta-2 adrenergic receptor	ADRB2	0.0337
737	Mineralocorticoid receptor	NR3C2	0.0337
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0333
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0331
731	HIV-1 protease	HIV-1 protease	0.0325
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0316
871	Glucocorticoid receptor	NR3C1	0.0316
632	Alpha-1B adrenergic receptor	ADRA1B	0.0314
756	Sex hormone-binding globulin	SHBG	0.0312
193	Beta-1 adrenergic receptor	ADRB1	0.0309
817	DNA topoisomerase 2-alpha	TOP2A	0.0304
847	Mu-type opioid receptor	OPRM1	0.0304
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0299
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0294
94	5-hydroxytryptamine 4 receptor	HTR4	0.0285
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0284
2390	Nonsecretory ribonuclease	RNASE2	0.0283
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0282
146	Androgen receptor	AR	0.0281
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.028
6143	Solute carrier family 22 member 7	SLC22A7	0.0279
136	Estrogen receptor	ESR1	0.0279
891	Dihydropteroate synthase	folP	0.0275
5359	Dihydropteroate synthase	folP	0.0275
7175	Dihydropteroate synthase	sulI	0.0275
6147	Solute carrier family 22 member 3	SLC22A3	0.0274
318	Alpha-2A adrenergic receptor	ADRA2A	0.0273
713	Sodium-dependent dopamine transporter	SLC6A3	0.027
23	D(1A) dopamine receptor	DRD1	0.0268
789	Alpha-1D adrenergic receptor	ADRA1D	0.0259
1024	Solute carrier family 22 member 11	SLC22A11	0.0255
6141	Sodium/bile acid cotransporter	SLC10A1	0.0254
844	Epidermal growth factor receptor	EGFR	0.0252
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0249
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0249
696	Kappa-type opioid receptor	OPRK1	0.0244
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0235
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0231
467	Delta-type opioid receptor	OPRD1	0.0227
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0225
6137	Multidrug resistance-associated protein 6	ABCC6	0.0219
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0219
614	Progesterone receptor	PGR	0.0209
465	Calmodulin	CALM1	0.0207
6102	Arylamine N-acetyltransferase 2	NAT2	0.0193
6148	Multidrug resistance-associated protein 7	ABCC10	0.0191
833	Organic cation/carnitine transporter 1	SLC22A4	0.019
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0181
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.018
6031	Cytochrome P450 3A43	CYP3A43	0.018
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0175
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0174
5682	Ribonuclease pancreatic	RNASE1	0.0173
468	Cytochrome P450 4A11	CYP4A11	0.0173
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0171
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0168
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0168
3941	Amine oxidase [flavin-containing] A	MAOA	0.0168
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0168
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0167
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0164
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0162
3923	Cholinesterase	BCHE	0.0159
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0159
738	Monocarboxylate transporter 1	SLC16A1	0.0153
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.015
183	Vascular endothelial growth factor A	VEGFA	0.0144
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
161	Tubulin beta chain	TUBB	0.0142
312	Tubulin beta chain	TUB2	0.0142
638	D(3) dopamine receptor	DRD3	0.0142
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0141
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0141
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0139
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0135
629	Alpha-2B adrenergic receptor	ADRA2B	0.0133
29	Tubulin beta-1 chain	TUBB1	0.0133
952	Dipeptidyl peptidase 4	DPP4	0.0132
5787	Angiopoietin-1 receptor	TEK	0.013
3307	Acriflavine resistance protein B	acrB	0.013
3939	Amine oxidase [flavin-containing] B	MAOB	0.0129
4604	Liver carboxylesterase 1	CES1	0.0128
6136	Multidrug resistance-associated protein 5	ABCC5	0.0126
373	Transthyretin	TTR	0.0126
378	Alpha-2C adrenergic receptor	ADRA2C	0.0125
6085	Fatty acid-binding protein, intestinal	FABP2	0.0122
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
6182	Cytochrome P450 2J2	CYP2J2	0.0116
1517	Beta-3 adrenergic receptor	ADRB3	0.0116
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0112
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0111
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0111
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0111
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0109
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0108
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0108
2211	Fatty acid-binding protein, heart	FABP3	0.0108
432	D(4) dopamine receptor	DRD4	0.0106
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0105
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0103
70	Type-1 angiotensin II receptor	AGTR1	0.0103
260	Cytochrome P450 51	ERG11	0.0102
761	Cytochrome P450 51	ERG11	0.0102
3163	Cytochrome P450 51	cyp51	0.0102
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0102
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0101
504	Mast/stem cell growth factor receptor	KIT	0.0101
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.01
469	Annexin A1	ANXA1	0.01
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0098
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0098
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0098
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0097
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0096
84	Nuclear receptor 0B1	NR0B1	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
566	Serotransferrin	TF	0.0094
869	Estrogen receptor beta	ESR2	0.0094
811	Translocator protein	TSPO	0.0093
122	P2Y purinoceptor 12	P2RY12	0.0093
232	Corticosteroid-binding globulin	SERPINA6	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
705	Glutamate receptor 1	GRIA1	0.0091
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.009
1656	CYP2B protein	CYP2B	0.0088
768	FK506-binding protein 1A	FKBP1A	0.0088
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0087
723	Cytosolic phospholipase A2	PLA2G4A	0.0087
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0087
474	Acetylcholinesterase	ACHE	0.0086
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0086
365	Dihydrofolate reductase	DHFR	0.0085
2381	Dihydrofolate reductase	DFR1	0.0085
2833	Dihydrofolate reductase	Not Available	0.0085
2931	Dihydrofolate reductase	folA	0.0085
3544	Dihydrofolate reductase	folA	0.0085
3682	Dihydrofolate reductase	folA	0.0085
6642	Dihydrofolate reductase	folA	0.0085
6756	Dihydrofolate reductase	dfrA	0.0085
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0085
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0085
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0085
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0082
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0082
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0081
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0081
163	D(1B) dopamine receptor	DRD5	0.0081
4120	NADPH--cytochrome P450 reductase	POR	0.0081
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.008
482	Glycine receptor subunit alpha-1	GLRA1	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
1757	Myeloperoxidase	MPO	0.0079
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0079
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
273	Apoptosis regulator Bcl-2	BCL2	0.0076
3932	Glutathione S-transferase A2	GSTA2	0.0076
477	DNA topoisomerase 4 subunit A	parC	0.0076
886	DNA topoisomerase 4 subunit A	parC	0.0076
6226	DNA topoisomerase 4 subunit A	parC	0.0076
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0076
716	5-hydroxytryptamine 7 receptor	HTR7	0.0075
404	DNA gyrase subunit A	gyrA	0.0075
6224	DNA gyrase subunit A	gyrA	0.0075
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0074
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0073
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0073
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0072
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0072
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
3947	Xanthine dehydrogenase/oxidase	XDH	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0071
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0071
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0071
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0071
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0071
1629	Transcription factor AP-1	JUN	0.007
1618	High affinity nerve growth factor receptor	NTRK1	0.007
7	Nitric oxide synthase, inducible	NOS2	0.007
4237	50S ribosomal protein L22	rplV	0.007
228	Beta platelet-derived growth factor receptor	PDGFRB	0.007
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0069
6020	Aldehyde oxidase	AOX1	0.0069
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0069
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0069
6043	Putative G-protein coupled receptor 44	GPR44	0.0068
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0068
2112	Toll-like receptor 9	TLR9	0.0068
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0067
6138	Multidrug resistance protein 3	ABCB4	0.0066
36	Insulin receptor	INSR	0.0066
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0066
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0066
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0065
124	Histamine H2 receptor	HRH2	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
1852	Microtubule-associated protein 2	MAP2	0.0063
6432	Transporter	snf	0.0062
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0061
558	Solute carrier family 12 member 1	SLC12A1	0.0061
2539	Tubulin alpha-1 chain	TUBA4A	0.0061
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0061
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.006
131	Synaptic vesicular amine transporter	SLC18A2	0.0059
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0059
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0059
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0059
6220	Aryl hydrocarbon receptor	AHR	0.0058
818	50S ribosomal protein L10	rplJ	0.0058
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0058
6149	Solute carrier family 22 member 10	SLC22A10	0.0058
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0058
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0058
5923	Microtubule-associated protein tau	MAPT	0.0057
5924	Microtubule-associated protein 4	MAP4	0.0057
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0057
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0056
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0056
407	Vascular endothelial growth factor receptor 2	KDR	0.0056
4238	50S ribosomal protein L4	rplD	0.0055
5578	50S ribosomal protein L4	rplD	0.0055
6173	50S ribosomal protein L4	rplD	0.0055
6219	50S ribosomal protein L4	rplD	0.0055
6506	Stathmin-4	STMN4	0.0055
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0055
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0054
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0054
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0054
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0054
88	Retinoic acid receptor RXR-beta	RXRB	0.0054
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0054
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0053
461	Glycine receptor subunit alpha-3	GLRA3	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
594	Thyroxine-binding globulin	SERPINA7	0.0053
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0052
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
2449	Tubulin alpha-3 chain	TUBA1A	0.005
904	Glutathione S-transferase P	GSTP1	0.005
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.005
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
4203	Histamine N-methyltransferase	HNMT	0.0049
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0049
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0049
4192	DNA topoisomerase 2-beta	TOP2B	0.0049
1541	Metalloproteinase	mmp20	0.0049
758	Thyroid hormone receptor alpha	THRA	0.0049
173	Toll-like receptor 7	TLR7	0.0049
275	Arachidonate 5-lipoxygenase	ALOX5	0.0049
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0048
856	Vitamin D3 receptor	VDR	0.0048
24	Thymidylate synthase	TMP1	0.0048
359	Thymidylate synthase	TYMS	0.0048
2626	Thymidylate synthase	thyA	0.0048
2729	Thymidylate synthase	thyA	0.0048
5352	Thymidylate synthase	THYA	0.0048
814	Ryanodine receptor 1	RYR1	0.0048
6014	Cytochrome P450 2A13	CYP2A13	0.0048
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0048
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0048
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0048
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0047
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0047
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0047
26	Vascular endothelial growth factor receptor 3	FLT4	0.0047
6103	Arylamine N-acetyltransferase 1	NAT1	0.0047
777	Tumor necrosis factor	TNF	0.0047
284	DNA-directed RNA polymerase beta chain	rpoB	0.0047
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0047
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0047
1010	Cytochrome P450 51A1	CYP51A1	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0046
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0046
33	Cystine/glutamate transporter	SLC7A11	0.0045
3086	Plasmepsin-2	Not Available	0.0045
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0045
32	Vascular endothelial growth factor receptor 1	FLT1	0.0045
6212	Tubulin gamma-1 chain	TUBG1	0.0045
6210	Tubulin delta chain	TUBD1	0.0045
6211	Tubulin epsilon chain	TUBE1	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0044
162	Retinoic acid receptor gamma-1	RARG	0.0044
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0044
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0044
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
346	Thyroid hormone receptor beta-1	THRB	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
489	Monocarboxylate transporter 2	SLC16A7	0.0043
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0043
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
1178	Adenosine A2a receptor	ADORA2A	0.0043
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0042
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0042
1353	DNA topoisomerase 1	TOP1	0.0042
3552	DNA topoisomerase 1	topA	0.0042
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1992	Vitamin D-binding protein	GC	0.0041
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0041
6677	Myelin P2 protein	PMP2	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.004
295	Carbonic anhydrase 1	CA1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
730	Retinoic acid receptor alpha	RARA	0.004
1864	RET proto-oncogene	RET	0.004
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.004
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.004
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.004
4210	Toll-like receptor 4	TLR4	0.0039
459	Retinoic acid receptor RXR-alpha	RXRA	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
357	Carbonic anhydrase 2	CA2	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
592	Carbonic anhydrase 4	CA4	0.0038
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0038
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0038
2021	Thrombomodulin	THBD	0.0038
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0037
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0037
3856	Fibroblast growth factor receptor 3	FGFR3	0.0037
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0036
1291	cAMP response element-binding protein	CREB1	0.0036
199	Monocarboxylate transporter 8	SLC16A2	0.0036
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0036
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0036
6837	Serine/threonine-protein kinase 17B	STK17B	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
4122	Histone deacetylase 2	HDAC2	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0036
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0035
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0035
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0035
4116	Dihydropteroate synthetase	Not Available	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
780	Retinoic acid receptor RXR-gamma	RXRG	0.0035
16	Adenosine A1 receptor	ADORA1	0.0035
518	Peroxidase/catalase T	katG	0.0035
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0035
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0035
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
1483	Membrane copper amine oxidase	AOC3	0.0034
6218	Pannexin-1	PANX1	0.0034
5300	Antigen peptide transporter 1	TAP1	0.0034
2599	Tyrosine-protein kinase HCK	HCK	0.0034
992	Protein tyrosine kinase 2 beta	PTK2B	0.0034
751	Potassium channel subfamily K member 6	KCNK6	0.0033
4773	Deoxycytidine kinase	DCK	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
921	Glutamate receptor 2	GRIA2	0.0033
6033	High affinity interleukin-8 receptor A	CXCR1	0.0033
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0033
581	Cytochrome P450 2R1	CYP2R1	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0033
4311	tRNA	TRDMT1	0.0032
4325	tRNA	trmD	0.0032
4328	tRNA	trmD	0.0032
6167	Organic solute transporter subunit beta	OSTB	0.0032
6166	Organic solute transporter subunit alpha	OSTA	0.0032
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0032
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0032
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0032
707	72 kDa type IV collagenase	MMP2	0.0032
174	Sigma 1-type opioid receptor	SIGMAR1	0.0032
1867	Major prion protein	PRNP	0.0032
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0032
908	Glutathione S-transferase theta-1	GSTT1	0.0032
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
5934	Cytochrome P450 26A1	CYP26A1	0.0031
473	L-lactate dehydrogenase A chain	LDHA	0.0031
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0031
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0031
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0031
6501	Fatty acid-binding protein, liver	FABP1	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0031
1648	Elastin	ELN	0.0031
172	Potassium channel subfamily K member 1	KCNK1	0.0031
427	Substance-P receptor	TACR1	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.003
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.003
3809	Estrogen-related receptor gamma	ESRRG	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
165	FL cytokine receptor	FLT3	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
244	Angiotensin-converting enzyme	ACE	0.0029
2207	Rhodopsin	RHO	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0028
1525	Heparin-binding growth factor 2	FGF2	0.0028
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0028
5431	Lipid binding protein	Not Available	0.0028
3616	Fatty acid-binding protein, epidermal	FABP5	0.0028
5433	UPF0230 protein TM_1468	TM_1468	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0028
65	Matrix metalloproteinase-9	Not Available	0.0028
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0028
634	Squalene monooxygenase	SQLE	0.0028
7196	Squalene monooxygenase	ERG1	0.0028
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0027
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
3810	Catechol O-methyltransferase	COMT	0.0027
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0027
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0027
6228	Nuclear receptor coactivator 1	NCOA1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0026
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0026
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0026
3587	Gastrotropin	FABP6	0.0026
1792	Tissue-type plasminogen activator	PLAT	0.0026
49	Endothelin B receptor	EDNRB	0.0026
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0026
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0026
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0025
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0025
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0025
4217	Telomerase reverse transcriptase	TERT	0.0025
3426	Glutamine synthetase	glnA	0.0025
3987	Glutamine synthetase	GLUL	0.0025
1313	Lactoylglutathione lyase	GLO1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
3937	Fatty-acid amide hydrolase	FAAH	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0024
6241	Nuclear receptor coactivator 2	NCOA2	0.0024
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0024
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0023
283	SEC14-like protein 2	SEC14L2	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0023
6151	Monocarboxylate transporter 10	SLC16A10	0.0023
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0023
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0023
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
6042	Prostaglandin reductase 2	PTGR2	0.0022
569	Retinal dehydrogenase 2	ALDH1A2	0.0022
6459	Glycodelin	PAEP	0.0022
5818	Folate receptor alpha	FOLR1	0.0022
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0022
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0022
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
3404	Exotoxin A	eta	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
6824	Tyrosine-protein kinase Lyn	LYN	0.0021
298	Renin	REN	0.0021
823	Fibroblast growth factor receptor 2	FGFR2	0.0021
319	Opioid receptor, sigma 1	OPRS1	0.0021
611	Retinal dehydrogenase 1	ALDH1A1	0.0021
4226	Uridine phosphorylase 2	UPP2	0.0021
6174	50S ribosomal protein L32	rpmF	0.0021
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0021
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
702	UMP-CMP kinase	CMPK1	0.0021
164	Histamine H4 receptor	HRH4	0.0021
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0021
5626	Nucleoside diphosphate kinase B	NME2	0.0021
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0021
822	Aldose reductase	AKR1B1	0.0021
1196	Complement decay-accelerating factor	CD55	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
239	Coagulation factor X	F10	0.002
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.002
976	Platelet glycoprotein IX	GP9	0.002
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.002
1630	Integrin beta-2	ITGB2	0.002
4103	Proteasome subunit beta type 2	PSMB2	0.002
4102	Proteasome subunit beta type 5	PSMB5	0.002
4101	Proteasome subunit beta type 1	PSMB1	0.002
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.002
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.002
6126	Carbonic anhydrase 7	CA7	0.002
6168	Solute carrier family 22 member 16	SLC22A16	0.002
2320	Thymidine kinase, cytosolic	TK1	0.002
4225	Uridine phosphorylase 1	UPP1	0.002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.002
517	Alcohol dehydrogenase 1C	ADH1C	0.002
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0019
2216	Fibroblast growth factor receptor 4	FGFR4	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0019
293	Gamma-glutamyl hydrolase	GGH	0.0019
6146	High affinity copper uptake protein 1	SLC31A1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
413	Amidophosphoribosyltransferase	PPAT	0.0018
2515	Amidophosphoribosyltransferase	purF	0.0018
3714	Amidophosphoribosyltransferase	purF	0.0018
2808	Chloramphenicol acetyltransferase 3	cat3	0.0018
4041	Microsomal glutathione S-transferase 2	MGST2	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
291	Nitric-oxide synthase, endothelial	NOS3	0.0017
6048	Troponin C, skeletal muscle	TNNC2	0.0017
5294	Nucleoside diphosphate kinase A	NME1	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
1650	Heme carrier protein 1	SLC46A1	0.0017
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0017
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0017
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0017
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0017
268	Adenosine A2b receptor	ADORA2B	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
3601	Dihydropteroate synthase 1	folP1	0.0017
3807	Dihydropteroate synthase 1	folP1	0.0017
3808	Dihydropteroate synthase 2	folP2	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0016
6044	Serum paraoxonase/lactonase 3	PON3	0.0016
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0016
144	Hemoglobin subunit alpha	HBA1	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
714	Glutathione reductase, mitochondrial	GSR	0.0016
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0016
816	Biliverdin reductase A	BLVRA	0.0016
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0016
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0016
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0016
1268	Neuropeptide S receptor	NPSR1	0.0016
76	Nitric-oxide synthase, brain	NOS1	0.0016
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0016
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0015
572	Integrin alpha-L	ITGAL	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
563	Thyroid peroxidase	TPO	0.0015
3639	Thymidine phosphorylase	deoA	0.0015
3936	Thymidine phosphorylase	TYMP	0.0015
251	Alcohol dehydrogenase 1A	ADH1A	0.0015
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0015
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0015
4031	Glutathione S-transferase A1	GSTA1	0.0014
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0014
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0014
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0014
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0014
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0014
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0014
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0014
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0014
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0014
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0014
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0014
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0014
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0014
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0014
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0014
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0014
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0014
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0014
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0014
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0014
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0014
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0014
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0014
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0014
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0014
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0014
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0014
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0014
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0014
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0014
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0014
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0014
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0014
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0014
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0014
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0014
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0014
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0014
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0014
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0014
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0014
644	Heme oxygenase 2	HMOX2	0.0014
4982	Heme oxygenase 2	pbsA2	0.0014
167	L-lactate dehydrogenase C chain	LDHC	0.0014
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0014
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0014
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0014
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0014
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0014
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0014
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0014
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0014
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0014
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0014
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0014
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0014
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0014
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0014
729	GDP-L-fucose synthetase	TSTA3	0.0014
3463	GDP-L-fucose synthetase	fcl	0.0014
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0014
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0014
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0014
34	7-dehydrocholesterol reductase	DHCR7	0.0014
711	UDP-glucose 6-dehydrogenase	UGDH	0.0014
3672	UDP-glucose 6-dehydrogenase	hasB	0.0014
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0014
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0014
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0014
107	C-4 methylsterol oxidase	SC4MOL	0.0014
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0014
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0014
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0014
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0014
206	3-keto-steroid reductase	HSD17B7	0.0014
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0014
643	Peroxisomal bifunctional enzyme	EHHADH	0.0014
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0014
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0014
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0014
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0014
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0014
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0014
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0014
2391	Ferrochelatase	hemH	0.0014
6502	Ferrochelatase	DKFZp686P18130	0.0014
1591	Ferrochelatase, mitochondrial	FECH	0.0014
6073	Potassium channel subfamily K member 9	KCNK9	0.0014
6072	Potassium channel subfamily K member 3	KCNK3	0.0014
396	Alcohol dehydrogenase 4	ADH4	0.0014
328	Sorbitol dehydrogenase	SORD	0.0014
597	Dihydropteridine reductase	QDPR	0.0014
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0014
760	Fibroblast growth factor 1	FGF1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0014
666	NADP-dependent malic enzyme	ME1	0.0014
896	Glutathione S-transferase Mu 1	GSTM1	0.0014
444	Alcohol dehydrogenase 1B	ADH1B	0.0013
857	Malate dehydrogenase, mitochondrial	MDH2	0.0013
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0013
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0013
810	Heme oxygenase 1	HMOX1	0.0013
3391	Heme oxygenase 1	pbsA1	0.0013
153	Dopamine beta-hydroxylase	DBH	0.0013
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0013
77	L-lactate dehydrogenase B chain	LDHB	0.0013
12	Alcohol dehydrogenase class 3	ADH5	0.0013
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
3904	Alanine aminotransferase 2	GPT2	0.0013
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0013
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0013
605	Fumarate reductase flavoprotein subunit	frdA	0.0013
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0013
3673	Fumarate reductase flavoprotein subunit	fccA	0.0013
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0013
6549	Fumarate reductase flavoprotein subunit	frdA	0.0013
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0012
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0012
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0012
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0012
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0012
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0012
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0012
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0012
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0012
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0012
6559	Cytochrome c oxidase subunit 2	ctaC	0.0012
6669	Cytochrome c oxidase subunit 2	ctaC	0.0012
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0012
6558	Cytochrome c oxidase subunit 1	ctaD	0.0012
6026	Alcohol dehydrogenase 6	ADH6	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0012
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0012
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0012
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0012
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0012
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
13	Aminomethyltransferase, mitochondrial	AMT	0.0012
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0012
1295	Fatty acid synthase	FASN	0.0012
626	Cysteine dioxygenase type 1	CDO1	0.0012
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0012
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0012
719	Retinoic acid receptor responder protein 1	RARRES1	0.0012
770	Retinoic acid-induced protein 3	GPRC5A	0.0012
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0011
936	Ephrin type-A receptor 2	EPHA2	0.0011
2540	Choloylglycine hydrolase	cbh	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
3957	Adenosine deaminase	ADA	0.0011
654	Flavin reductase	BLVRB	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
54	Prothrombin	F2	0.001
5798	Mitogen-activated protein kinase 11	MAPK11	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
1374	Natriuretic peptides B	NPPB	0.001
279	Tyrosinase	TYR	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
267	Plasminogen activator inhibitor 1	SERPINE1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
511	5-hydroxytryptamine 1F receptor	HTR1F	0.001
1928	Leukotriene C4 synthase	LTC4S	0.001
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.001
4034	Glutaredoxin-1	GLRX	0.001
910	Epididymal secretory glutathione peroxidase	GPX5	0.001
4036	Glutathione peroxidase 6	GPX6	0.001
4037	Hypothetical protein	GPX1	0.001
4297	Hypothetical protein	SP_1951	0.001
4521	Hypothetical protein	BC_2969	0.001
4540	Hypothetical protein	TM_1070	0.001
4555	Hypothetical protein	MT1739	0.001
4569	Hypothetical protein	mshD	0.001
4578	Hypothetical protein	PA3270	0.001
4747	Hypothetical protein	PA3967	0.001
5177	Hypothetical protein	TM_0096	0.001
5194	Hypothetical protein	PA1204	0.001
5240	Hypothetical protein	Rv2991	0.001
5370	Hypothetical protein	TM_1158	0.001
5710	Hypothetical protein	Tb927.5.1360	0.001
4029	Microsomal glutathione S-transferase 3	MGST3	0.001
900	Glutathione S-transferase A4	GSTA4	0.001
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.001
911	Glutathione peroxidase 3	GPX3	0.001
4040	Glutathione peroxidase 7	GPX7	0.001
907	Glutathione peroxidase 2	GPX2	0.001
4032	Microsomal glutathione S-transferase 1	MGST1	0.001
906	Glutathione peroxidase 1	GPX1	0.001
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.001
4035	Glutathione S-transferase Mu 5	GSTM5	0.001
903	Glutathione S-transferase A5	GSTA5	0.001
4042	Glutathione transferase omega-2	GSTO2	0.001
4033	S-formylglutathione hydrolase	ESD	0.001
4038	Glutathione peroxidase 4	GPX4	0.001
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.001
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.001
6221	Steroid hormone receptor ERR1	ESRRA	0.0009
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
2298	Cytochrome P450-cam	camC	0.0009
1039	Histone deacetylase 9	HDAC9	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0009
6500	Phospholipase A2	PLA2G1B	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
898	Glutathione S-transferase A3	GSTA3	0.0009
897	Glutathione S-transferase kappa 1	GSTK1	0.0009
909	Maleylacetoacetate isomerase	GSTZ1	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
899	Glutathione S-transferase Mu 3	GSTM3	0.0008
905	Glutathione transferase omega-1	GSTO1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2232	Interleukin-5	IL5	0.0008
2165	Glutathione S-transferase Mu 2	GSTM2	0.0008
1593	Mucin-2	MUC2	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
207	Glutathione synthetase	GSS	0.0008
5269	Glutathione synthetase	gshB	0.0008
1025	Aquaporin-1	AQP1	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
901	Glutathione S-transferase Mu 4	GSTM4	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
4943	Cytochrome c6	petJ	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4916	Cyanoglobin	glbN	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
5000	HemO	hemO	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
4984	Neuroglobin	NGB	0.0006
4961	Hemophore HasA	hasA	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4909	CooA protein	cooA	0.0006
3116	Bacterioferritin	bfr	0.0006
4906	Bacterioferritin	bfr	0.0006
4965	Bacterioferritin	bfr	0.0006
4910	Cytoglobin	CYGB	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4972	P450cin	cinA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4952	Catalase/peroxidase	katA	0.0006
3093	Catalase HPII	katE	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
4920	Peroxidase/catalase	katG	0.0005
5961	Insulin	INS	0.0005
4948	Cytochrome c-553	Not Available	0.0005
2119	Cytochrome b5	CYB5A	0.0005
4923	Cytochrome c3	DvMF_2499	0.0005
4945	Cytochrome c3	Not Available	0.0005
4949	Cytochrome c3	DVU_3171	0.0005
4968	Cytochrome c3	cytc3	0.0005
4997	Cytochrome c3	SO_2727	0.0005
5219	Cytochrome c3	cyd	0.0005
4902	Nine-heme cytochrome c	Ddes_2038	0.0005
3189	High-molecular-weight cytochrome c	hmcA	0.0005
4990	PpcA	ppcA	0.0005
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0005
3375	Acidic cytochrome c3	Not Available	0.0005
4988	Sulfite oxidase, mitochondrial	SUOX	0.0005
3570	Cytochrome P450 152A1	cypC	0.0005
2915	Sensor protein fixL	fixL	0.0005
4944	Sensor protein fixL	fixL	0.0005
4813	Heme oxygenase	hmuO	0.0005
5769	Heme oxygenase	Not Available	0.0005
4289	Cytochrome P450	TT_P0059	0.0005
6262	Cytochrome P450	staP	0.0005
4385	Cytochrome c'	Not Available	0.0005
4967	Cytochrome c'	cycA	0.0005
5038	Cytochrome c'	Not Available	0.0005
5223	Cytochrome c'	cycP	0.0005
4992	Cytochrome c peroxidase	Not Available	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
6755	Poliovirus receptor	PVR	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
4386	Hemoglobin-like protein HbN	glbN	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
3127	Nitrite reductase	nirS	0.0004
3284	Nitrite reductase	nirS	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0004
3221	Cytochrome c4	cc4	0.0004
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0004
2297	Genome polyprotein	Not Available	0.0004
2322	Genome polyprotein	Not Available	0.0004
2694	Genome polyprotein	Not Available	0.0004
2719	Genome polyprotein	Not Available	0.0004
2860	Genome polyprotein	Not Available	0.0004
2928	Genome polyprotein	Not Available	0.0004
3160	Genome polyprotein	Not Available	0.0004
3260	Genome polyprotein	Not Available	0.0004
4783	Genome polyprotein	Not Available	0.0004
5726	Genome polyprotein	Not Available	0.0004
5779	Genome polyprotein	Not Available	0.0004
5867	Genome polyprotein	Not Available	0.0004
6253	Genome polyprotein	Not Available	0.0004
6301	Genome polyprotein	Not Available	0.0004
6380	Genome polyprotein	Not Available	0.0004
6381	Genome polyprotein	Not Available	0.0004
6437	Genome polyprotein	Not Available	0.0004
6520	Genome polyprotein	Not Available	0.0004
6521	Genome polyprotein	Not Available	0.0004
6652	Genome polyprotein	Not Available	0.0004
6734	Genome polyprotein	Not Available	0.0004
6735	Genome polyprotein	Not Available	0.0004
6736	Genome polyprotein	Not Available	0.0004
6737	Genome polyprotein	Not Available	0.0004
6738	Genome polyprotein	Not Available	0.0004
6739	Genome polyprotein	Not Available	0.0004
6744	Genome polyprotein	Not Available	0.0004
6748	Genome polyprotein	Not Available	0.0004
6894	Genome polyprotein	Not Available	0.0004
6898	Genome polyprotein	Not Available	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
1507	Cytochrome c	CYCS	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB05812 - Abiraterone

Targets

Enzymes

Transporters

Carriers

Predictions