DT-Web: DB06616

Identification

Name

Bosutinib

Accession Number

DB06616

Type

small molecule

Description

Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antineoplastic Agents

Molecular Weight

530.446

Groups

approved

Monoisotopic Weight

529.164745233

Pharmacology

Indication

Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.

Mechanism of action

Bosutinib is a tyrosine kinase inhibitor. Although it is able to inhibit several tyrosine kinases such as Src, Lyn, and Hck, which are members of the Src-family of kinases, its primary target is the Bcr-Abl kinase. The Bcr-Abl gene is a chimeric oncogene created from the fusion of the breakpoint-cluster (Bcr) gene and Abelson (Abl) tyrosine gene. This chromosomal abnormality results in the formation of what is commonly known as the Philadelphia chromosome or Philadelphia translocation. The Bcr-Abl gene expresses a particular kinase that promotes the progression of CML. A decrease in the growth and size of the CML tumour has been observed following administration of bosutinib. Bosutinib did not inhibit the T315I and V299L mutant cells.

Absorption

Food increase the exposure of bosutinib. Tmax, single dose, cancer patients, fed-state = 4-6 hours; After 15 daily doses of bosutinib 500 mg with food in CML patients, the pharmacokinetic parameters are as follows: Cmax = 200 ng/mL; AUC = 3650 ng?h/mL

Protein binding

94% bound to human plasma proteins in vitro. 96% bound to human plasma proteins in healthy subjects ex vivo. Extent of protein binding is not concentration-dependent.

Biotransformation

Bosutinib is primarily metabolized by CYP3A4. The major circulating metabolites identified in plasma are oxydechlorinated (M2) bosutinib (19% of parent exposure) and N-desmethylated (M5) bosutinib (25% of parent exposure), with bosutinib N-oxide (M6) as a minor circulating metabolite. All the metabolites were deemed inactive.

Route of elimination

When given a single oral dose, 91.3% of the dose was recovered in feces and 3% of the dose recovered in urine.

Toxicity

Most common adverse reactions (incidence greater than 20%) are diarrhea, nausea, thrombocytopenia, vomiting, abdominal pain, rash, anemia, pyrexia, and fatigue. Because bosutinib is not an inhibitor of c-KIT or PDGF receptor, it has less hematologic toxicities.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Abiraterone	Abiraterone increases levels by P-glycoprotein (MDR1) efflux transporter. Consider alternate therapy.
Crizotinib	Strong CYP3A4 inhibitors may increase levels of crizotinib. Consider alternative therapy.
Digoxin	Bosutinib is a substrate and inhibitor of p-glycoprotein (p-gp) and may increase levels of other p-gp substrates.
Etravirine	Bosutinib, when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to avoid this combination.
Ketoconazole	Strong CYP3A4 inhibitors may increase levels of bosutinib. Monitor concomitant therapy closely.
Lansoprazole	Concomitant lansoprazole (PPI) decreased bosutinib Cmax by 46% and AUC by 26% compared to bosutinib alone. Consider using short-acting antacids or H2 blockers instead of PPIs to avoid a reduction in bosutinib exposure. Separate antacid or H2 blocker dosing and BOSULIF dosing by more than 2 hours.
Rifampin	Strong CYP3A4 inducers may decrease levels of bosutinib. Monitor concomitant therapy closely.

Food Interactions

When given with a high fat meal, the Cmax and AUC of bosutinib increased 1.8- and 1.7-fold, respectively.

Breakpoint cluster region protein
Name	Breakpoint cluster region protein
Gene Name	Not Available
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	Not Available
Proto-oncogene tyrosine-protein kinase ABL1
Name	Proto-oncogene tyrosine-protein kinase ABL1
Gene Name	ABL1
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.9436
Tyrosine-protein kinase Lyn
Name	Tyrosine-protein kinase Lyn
Gene Name	LYN
Pharmacological action	unknown
Actions	Not Available
References	FDA label -
DTHybrid score	0.5577
Tyrosine-protein kinase HCK
Name	Tyrosine-protein kinase HCK
Gene Name	HCK
Pharmacological action	unknown
Actions	inhibitor
References	FDA label -
DTHybrid score	0.7183
Proto-oncogene tyrosine-protein kinase Src
Name	Proto-oncogene tyrosine-protein kinase Src
Gene Name	SRC
Pharmacological action	unknown
Actions	inhibitor
References	FDA label -
DTHybrid score	1.9504
Cell division protein kinase 2
Name	Cell division protein kinase 2
Gene Name	CDK2
Pharmacological action	unknown
Actions	inhibitor
References	Remsing Rix LL, Rix U, Colinge J, Hantschel O, Bennett KL, Stranzl T, Muller A, Baumgartner C, Valent P, Augustin M, Till JH, Superti-Furga G: Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells. Leukemia. 2009 Mar;23(3):477-85. doi: 10.1038/leu.2008.334. Epub 2008 Nov 27. - Pubmed
DTHybrid score	1.735
Dual specificity mitogen-activated protein kinase kinase 1
Name	Dual specificity mitogen-activated protein kinase kinase 1
Gene Name	MAP2K1
Pharmacological action	unknown
Actions	inhibitor
References	Remsing Rix LL, Rix U, Colinge J, Hantschel O, Bennett KL, Stranzl T, Muller A, Baumgartner C, Valent P, Augustin M, Till JH, Superti-Furga G: Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells. Leukemia. 2009 Mar;23(3):477-85. doi: 10.1038/leu.2008.334. Epub 2008 Nov 27. - Pubmed
DTHybrid score	1.729
Dual specificity mitogen-activated protein kinase kinase 2
Name	Dual specificity mitogen-activated protein kinase kinase 2
Gene Name	Not Available
Pharmacological action	unknown
Actions	inhibitor
References	Remsing Rix LL, Rix U, Colinge J, Hantschel O, Bennett KL, Stranzl T, Muller A, Baumgartner C, Valent P, Augustin M, Till JH, Superti-Furga G: Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells. Leukemia. 2009 Mar;23(3):477-85. doi: 10.1038/leu.2008.334. Epub 2008 Nov 27. - Pubmed
DTHybrid score	Not Available
Mitogen-activated protein kinase kinase kinase 2
Name	Mitogen-activated protein kinase kinase kinase 2
Gene Name	Not Available
Pharmacological action	unknown
Actions	inhibitor
References	Ahmad S, Hughes MA, Johnson GL, Scott JE: Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors. J Biomol Screen. 2013 Apr;18(4):388-99. doi: 10.1177/1087057112466430. Epub 2012 Nov 7. - Pubmed
DTHybrid score	Not Available
Calcium/calmodulin-dependent protein kinase type II gamma chain
Name	Calcium/calmodulin-dependent protein kinase type II gamma chain
Gene Name	CAMK2G
Pharmacological action	unknown
Actions	inhibitor
References	Amsberg GK, Koschmieder S: Profile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemia. Onco Targets Ther. 2013;6:99-106. doi: 10.2147/OTT.S19901. Epub 2013 Mar 4. - Pubmed
DTHybrid score	1.2938

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	FDA label -
DTHybrid score	0.4131

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	FDA label -
DTHybrid score	0.3531

Id	Partner name	Gene Name	Score
6235	Cyclin-A2	CCNA2	0.2743
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.2238
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.2
504	Mast/stem cell growth factor receptor	KIT	0.1751
4924	Cytochrome P450 2C8	CYP2C8	0.112
4119	Cytochrome P450 2D6	CYP2D6	0.1102
4118	Cytochrome P450 3A5	CYP3A5	0.1018
1144	Hepatocyte growth factor receptor	MET	0.0936
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.083
4757	Cytochrome P450 2C9	CYP2C9	0.0806
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0801
6016	Cytochrome P450 2C19	CYP2C19	0.0742
4200	Cytochrome P450 1A2	CYP1A2	0.0732
6107	Cytochrome P450 3A7	CYP3A7	0.058
6030	Cytochrome P450 2B6	CYP2B6	0.0537
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0454
5787	Angiopoietin-1 receptor	TEK	0.0431
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0427
2216	Fibroblast growth factor receptor 4	FGFR4	0.042
3856	Fibroblast growth factor receptor 3	FGFR3	0.0397
6013	Cytochrome P450 2E1	CYP2E1	0.0374
823	Fibroblast growth factor receptor 2	FGFR2	0.0372
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.037
587	Serum albumin	ALB	0.0364
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0363
6024	Cytochrome P450 1A1	CYP1A1	0.0354
407	Vascular endothelial growth factor receptor 2	KDR	0.0343
862	Multidrug resistance-associated protein 1	ABCC1	0.0338
776	Bile salt export pump	ABCB11	0.0329
165	FL cytokine receptor	FLT3	0.0313
844	Epidermal growth factor receptor	EGFR	0.0309
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0308
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0302
6837	Serine/threonine-protein kinase 17B	STK17B	0.0302
6782	Ribosomal protein S6 kinase alpha-1	RPS6KA1	0.0273
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0264
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0263
871	Glucocorticoid receptor	NR3C1	0.0262
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0261
1742	D-HSCDK2	CDK2deltaT	0.025
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0249
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0243
5718	Cytochrome P450 2A6	CYP2A6	0.0236
1771	Cell division control protein 2 homolog	CDK1	0.023
3321	Cell division control protein 2 homolog	CRK2	0.023
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0228
1058	Cell division protein kinase 5	CDK5	0.022
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0219
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0219
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0219
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0218
6460	Casein kinase I isoform gamma-3	CSNK1G3	0.0207
492	Histamine H1 receptor	HRH1	0.0204
556	Alpha-1A adrenergic receptor	ADRA1A	0.0199
6145	Solute carrier family 22 member 1	SLC22A1	0.0192
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0191
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0191
3811	Cytochrome P450 19A1	CYP19A1	0.0189
6142	Solute carrier family 22 member 8	SLC22A8	0.0188
1540	Mitogen-activated protein kinase 14	MAPK14	0.0187
20	Prostaglandin G/H synthase 1	PTGS1	0.0186
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0181
936	Ephrin type-A receptor 2	EPHA2	0.018
824	Sodium-dependent serotonin transporter	SLC6A4	0.018
1898	Cytochrome P450 1B1	CYP1B1	0.0178
136	Estrogen receptor	ESR1	0.0174
489	Monocarboxylate transporter 2	SLC16A7	0.0174
6144	Solute carrier family 22 member 2	SLC22A2	0.0164
831	D(2) dopamine receptor	DRD2	0.0162
1729	Solute carrier family 22 member 6	SLC22A6	0.0157
738	Monocarboxylate transporter 1	SLC16A1	0.0155
484	Tyrosine-protein kinase ABL2	ABL2	0.0151
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0148
103	Muscarinic acetylcholine receptor M1	CHRM1	0.014
3923	Cholinesterase	BCHE	0.0138
731	HIV-1 protease	HIV-1 protease	0.0137
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0134
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0132
847	Mu-type opioid receptor	OPRM1	0.0132
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0131
193	Beta-1 adrenergic receptor	ADRB1	0.0127
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0126
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0126
318	Alpha-2A adrenergic receptor	ADRA2A	0.0125
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0123
6106	Cytochrome P450 2C18	CYP2C18	0.0121
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.012
1618	High affinity nerve growth factor receptor	NTRK1	0.0119
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0119
766	Beta-2 adrenergic receptor	ADRB2	0.0118
4609	U1 small nuclear ribonucleoprotein A	SNRPA	0.0117
632	Alpha-1B adrenergic receptor	ADRA1B	0.0115
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0115
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0115
467	Delta-type opioid receptor	OPRD1	0.0113
260	Cytochrome P450 51	ERG11	0.0112
761	Cytochrome P450 51	ERG11	0.0112
3163	Cytochrome P450 51	cyp51	0.0112
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.011
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0109
23	D(1A) dopamine receptor	DRD1	0.0104
290	Prostaglandin G/H synthase 2	PTGS2	0.0104
1422	Serine/threonine-protein kinase 6	AURKA	0.0104
614	Progesterone receptor	PGR	0.0103
817	DNA topoisomerase 2-alpha	TOP2A	0.0102
4563	Acetyl transferase	rimL	0.0102
2750	Aspartate 1-decarboxylase	panD	0.0102
118	Organic cation/carnitine transporter 2	SLC22A5	0.0098
26	Vascular endothelial growth factor receptor 3	FLT4	0.0097
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0097
789	Alpha-1D adrenergic receptor	ADRA1D	0.0097
696	Kappa-type opioid receptor	OPRK1	0.0095
32	Vascular endothelial growth factor receptor 1	FLT1	0.0094
6143	Solute carrier family 22 member 7	SLC22A7	0.0094
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0094
3490	Sigma factor sigB regulation protein rsbQ	rsbQ	0.0094
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0094
232	Corticosteroid-binding globulin	SERPINA6	0.0091
274	Muscarinic acetylcholine receptor M5	CHRM5	0.009
4600	Malonamidase E2	Not Available	0.0088
6182	Cytochrome P450 2J2	CYP2J2	0.0088
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0088
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0088
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0086
4608	Putative cytochrome P450	SCO1207	0.0085
4963	Putative cytochrome P450	SCO2884	0.0085
6254	Putative cytochrome P450	SCO6998	0.0085
818	50S ribosomal protein L10	rplJ	0.0085
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0084
5798	Mitogen-activated protein kinase 11	MAPK11	0.0084
465	Calmodulin	CALM1	0.0084
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0083
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0082
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0082
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0082
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0081
885	5-hydroxytryptamine 1B receptor	HTR1B	0.008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.008
2164	Multidrug resistance-associated protein 4	ABCC4	0.0079
1176	Mitogen-activated protein kinase 1	MAPK1	0.0079
4604	Liver carboxylesterase 1	CES1	0.0078
2616	Ganglioside GM2 activator	GM2A	0.0078
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0078
952	Dipeptidyl peptidase 4	DPP4	0.0077
629	Alpha-2B adrenergic receptor	ADRA2B	0.0074
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0073
3959	Cell division protein kinase 4	CDK4	0.0073
474	Acetylcholinesterase	ACHE	0.0073
161	Tubulin beta chain	TUBB	0.0073
312	Tubulin beta chain	TUB2	0.0073
122	P2Y purinoceptor 12	P2RY12	0.0072
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0071
638	D(3) dopamine receptor	DRD3	0.0071
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.007
713	Sodium-dependent dopamine transporter	SLC6A3	0.0069
244	Angiotensin-converting enzyme	ACE	0.0068
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0068
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0068
1864	RET proto-oncogene	RET	0.0068
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0068
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0068
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0068
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0068
6148	Multidrug resistance-associated protein 7	ABCC10	0.0068
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0067
6147	Solute carrier family 22 member 3	SLC22A3	0.0067
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0066
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0066
6137	Multidrug resistance-associated protein 6	ABCC6	0.0066
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0066
29	Tubulin beta-1 chain	TUBB1	0.0066
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0065
869	Estrogen receptor beta	ESR2	0.0065
768	FK506-binding protein 1A	FKBP1A	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
378	Alpha-2C adrenergic receptor	ADRA2C	0.0063
1353	DNA topoisomerase 1	TOP1	0.0063
3552	DNA topoisomerase 1	topA	0.0063
124	Histamine H2 receptor	HRH2	0.0062
4237	50S ribosomal protein L22	rplV	0.0062
4120	NADPH--cytochrome P450 reductase	POR	0.0062
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0061
833	Organic cation/carnitine transporter 1	SLC22A4	0.006
1192	Sulfotransferase 1A1	SULT1A1	0.006
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
756	Sex hormone-binding globulin	SHBG	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0058
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0058
6031	Cytochrome P450 3A43	CYP3A43	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
6141	Sodium/bile acid cotransporter	SLC10A1	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
146	Androgen receptor	AR	0.0056
1024	Solute carrier family 22 member 11	SLC22A11	0.0055
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0055
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0055
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0055
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0055
477	DNA topoisomerase 4 subunit A	parC	0.0054
886	DNA topoisomerase 4 subunit A	parC	0.0054
6226	DNA topoisomerase 4 subunit A	parC	0.0054
468	Cytochrome P450 4A11	CYP4A11	0.0054
3941	Amine oxidase [flavin-containing] A	MAOA	0.0053
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0053
404	DNA gyrase subunit A	gyrA	0.0053
6224	DNA gyrase subunit A	gyrA	0.0053
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0052
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0052
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0051
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0051
70	Type-1 angiotensin II receptor	AGTR1	0.0051
716	5-hydroxytryptamine 7 receptor	HTR7	0.0051
6755	Poliovirus receptor	PVR	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.005
777	Tumor necrosis factor	TNF	0.005
737	Mineralocorticoid receptor	NR3C2	0.005
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0049
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0049
6085	Fatty acid-binding protein, intestinal	FABP2	0.0049
6321	Cyclin-dependent kinase 5 activator 1	CDK5R1	0.0049
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0049
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0047
4238	50S ribosomal protein L4	rplD	0.0047
5578	50S ribosomal protein L4	rplD	0.0047
6173	50S ribosomal protein L4	rplD	0.0047
6219	50S ribosomal protein L4	rplD	0.0047
340	Apoptotic protease-activating factor 1	APAF1	0.0047
3939	Amine oxidase [flavin-containing] B	MAOB	0.0047
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0047
683	Potassium transporter	GK0582	0.0047
1714	Mitogen-activated protein kinase 3	MAPK3	0.0046
68	Cannabinoid receptor 1	CNR1	0.0045
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0045
811	Translocator protein	TSPO	0.0044
292	Activin receptor type-1	ACVR1	0.0044
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0044
849	Activated CDC42 kinase 1	TNK2	0.0044
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0044
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0044
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0044
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0044
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0044
380	Cytochrome P450 17A1	CYP17A1	0.0044
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0044
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0044
4210	Toll-like receptor 4	TLR4	0.0044
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0044
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0044
3947	Xanthine dehydrogenase/oxidase	XDH	0.0044
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0044
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0043
432	D(4) dopamine receptor	DRD4	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
6136	Multidrug resistance-associated protein 5	ABCC5	0.0043
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0042
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0042
395	ALK tyrosine kinase receptor	Not Available	0.0042
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0042
733	Activin receptor type 1B	ACVR1B	0.0042
825	Arsenical pump-driving ATPase	ASNA1	0.0042
3435	Arsenical pump-driving ATPase	arsA	0.0042
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0042
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0042
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0042
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0042
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0042
154	AFG3-like protein 2	AFG3L2	0.0042
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0042
373	Transthyretin	TTR	0.0042
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0042
1852	Microtubule-associated protein 2	MAP2	0.0042
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1656	CYP2B protein	CYP2B	0.0041
394	Calcineurin subunit B isoform 1	PPP3R1	0.0041
6753	Apolipoprotein M	APOM	0.0041
6742	Recoverin	RCVRN	0.0041
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0041
6747	Chalcone/stilbene synthase family protein	MT1417	0.0041
6743	Non-fluorescent flavoprotein	luxF	0.0041
2528	Fatty acid metabolism regulator protein	fadR	0.0041
6740	Fatty acid metabolism regulator protein	fadR	0.0041
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0041
6751	Gag polyprotein	gag	0.0041
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0041
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0041
6749	Polyprotein	Not Available	0.0041
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.004
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.004
2297	Genome polyprotein	Not Available	0.004
2322	Genome polyprotein	Not Available	0.004
2694	Genome polyprotein	Not Available	0.004
2719	Genome polyprotein	Not Available	0.004
2860	Genome polyprotein	Not Available	0.004
2928	Genome polyprotein	Not Available	0.004
3160	Genome polyprotein	Not Available	0.004
3260	Genome polyprotein	Not Available	0.004
4783	Genome polyprotein	Not Available	0.004
5726	Genome polyprotein	Not Available	0.004
5779	Genome polyprotein	Not Available	0.004
5867	Genome polyprotein	Not Available	0.004
6253	Genome polyprotein	Not Available	0.004
6301	Genome polyprotein	Not Available	0.004
6380	Genome polyprotein	Not Available	0.004
6381	Genome polyprotein	Not Available	0.004
6437	Genome polyprotein	Not Available	0.004
6520	Genome polyprotein	Not Available	0.004
6521	Genome polyprotein	Not Available	0.004
6652	Genome polyprotein	Not Available	0.004
6734	Genome polyprotein	Not Available	0.004
6735	Genome polyprotein	Not Available	0.004
6736	Genome polyprotein	Not Available	0.004
6737	Genome polyprotein	Not Available	0.004
6738	Genome polyprotein	Not Available	0.004
6739	Genome polyprotein	Not Available	0.004
6744	Genome polyprotein	Not Available	0.004
6748	Genome polyprotein	Not Available	0.004
6894	Genome polyprotein	Not Available	0.004
6898	Genome polyprotein	Not Available	0.004
132	ATP-binding cassette sub-family A member 1	ABCA1	0.004
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0039
814	Ryanodine receptor 1	RYR1	0.0039
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0039
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
2539	Tubulin alpha-1 chain	TUBA4A	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
661	ADP/ATP translocase 1	SLC25A4	0.0037
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0037
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0037
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0037
297	Adenylate cyclase type 1	ADCY1	0.0037
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0036
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0036
5961	Insulin	INS	0.0036
6020	Aldehyde oxidase	AOX1	0.0036
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0036
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0036
6527	Lymphocyte antigen 96	LY96	0.0036
2473	Tyrosine-protein kinase CSK	CSK	0.0036
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.0036
856	Vitamin D3 receptor	VDR	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0034
6750	ADP-ribosylation factor 6	ARF6	0.0033
6021	Adenosine kinase	ADK	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0033
6524	Protein tonB	tonB	0.0033
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0032
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0032
284	DNA-directed RNA polymerase beta chain	rpoB	0.0032
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
6316	ADP-ribosylation factor 1	ARF1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0031
740	Argininosuccinate synthase	ASS1	0.0031
865	Argininosuccinate synthase	ASS1	0.0031
2680	Argininosuccinate synthase	argG	0.0031
3194	Argininosuccinate synthase	argG	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
239	Coagulation factor X	F10	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
295	Carbonic anhydrase 1	CA1	0.003
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.003
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.003
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0029
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0029
1629	Transcription factor AP-1	JUN	0.0029
2530	Protein kinase C theta type	PRKCQ	0.0028
319	Opioid receptor, sigma 1	OPRS1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
6228	Nuclear receptor coactivator 1	NCOA1	0.0028
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0028
3950	Cell division protein kinase 9	CDK9	0.0028
163	D(1B) dopamine receptor	DRD5	0.0028
3968	Cell division protein kinase 8	CDK8	0.0028
3932	Glutathione S-transferase A2	GSTA2	0.0028
4103	Proteasome subunit beta type 2	PSMB2	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
24	Thymidylate synthase	TMP1	0.0027
359	Thymidylate synthase	TYMS	0.0027
2626	Thymidylate synthase	thyA	0.0027
2729	Thymidylate synthase	thyA	0.0027
5352	Thymidylate synthase	THYA	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0027
1010	Cytochrome P450 51A1	CYP51A1	0.0027
864	Gag-Pol polyprotein	gag-pol	0.0026
2237	Gag-Pol polyprotein	gag-pol	0.0026
2326	Gag-Pol polyprotein	gag-pol	0.0026
2451	Gag-Pol polyprotein	gag-pol	0.0026
2901	Gag-Pol polyprotein	gag-pol	0.0026
3165	Gag-Pol polyprotein	gag-pol	0.0026
3722	Gag-Pol polyprotein	gag-pol	0.0026
6306	Gag-Pol polyprotein	gag-pol	0.0026
6624	Gag-Pol polyprotein	gag-pol	0.0026
904	Glutathione S-transferase P	GSTP1	0.0026
5300	Antigen peptide transporter 1	TAP1	0.0026
1178	Adenosine A2a receptor	ADORA2A	0.0026
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
49	Endothelin B receptor	EDNRB	0.0026
427	Substance-P receptor	TACR1	0.0026
6220	Aryl hydrocarbon receptor	AHR	0.0026
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0025
2408	Tyrosine-protein kinase SYK	SYK	0.0025
3482	Cell division protein kinase 7	CDK7	0.0024
1517	Beta-3 adrenergic receptor	ADRB3	0.0024
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0024
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
705	Glutamate receptor 1	GRIA1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0024
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
357	Carbonic anhydrase 2	CA2	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
365	Dihydrofolate reductase	DHFR	0.0024
2381	Dihydrofolate reductase	DFR1	0.0024
2833	Dihydrofolate reductase	Not Available	0.0024
2931	Dihydrofolate reductase	folA	0.0024
3544	Dihydrofolate reductase	folA	0.0024
3682	Dihydrofolate reductase	folA	0.0024
6642	Dihydrofolate reductase	folA	0.0024
6756	Dihydrofolate reductase	dfrA	0.0024
4341	Beta crystallin B1	CRYBB1	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
4340	Hypothetical conserved protein	GK2698	0.0024
6484	Hypothetical conserved protein	TT_C0834	0.0024
4339	Sucrose phosphorylase	sucP	0.0024
1434	Protein DJ-1	PARK7	0.0024
4336	Glyceraldehyde 3-phosphate dehydrogenase	Not Available	0.0024
4436	Glyceraldehyde 3-phosphate dehydrogenase	tthHB8IM	0.0024
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0024
6014	Cytochrome P450 2A13	CYP2A13	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0023
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0023
2427	Ferrichrome-iron receptor	fhuA	0.0023
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
6102	Arylamine N-acetyltransferase 2	NAT2	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0022
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0022
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0022
4773	Deoxycytidine kinase	DCK	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0022
1050	Bile salt sulfotransferase	SULT2A1	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0021
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0021
3421	Hydroxyethylthiazole kinase	thiM	0.0021
2688	Peptide deformylase	def	0.0021
2708	Peptide deformylase	def	0.0021
3004	Peptide deformylase	def	0.0021
4337	Peptide deformylase	def	0.0021
4338	Peptide deformylase	def	0.0021
5368	Peptide deformylase	def	0.0021
5371	Peptide deformylase	def	0.0021
6375	Peptide deformylase	def	0.0021
6378	Peptide deformylase	def	0.0021
6379	Peptide deformylase	def	0.0021
6776	Peptide deformylase	def	0.0021
6900	Peptide deformylase	def	0.0021
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0021
6432	Transporter	snf	0.002
4203	Histamine N-methyltransferase	HNMT	0.002
780	Retinoic acid receptor RXR-gamma	RXRG	0.002
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
273	Apoptosis regulator Bcl-2	BCL2	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0019
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0019
3105	M-phase inducer phosphatase 2	CDC25B	0.0019
4343	Alpha-glucosidase	aglA	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
54	Prothrombin	F2	0.0019
6149	Solute carrier family 22 member 10	SLC22A10	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0019
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
88	Retinoic acid receptor RXR-beta	RXRB	0.0019
6167	Organic solute transporter subunit beta	OSTB	0.0019
6166	Organic solute transporter subunit alpha	OSTA	0.0019
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0018
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0018
2112	Toll-like receptor 9	TLR9	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
469	Annexin A1	ANXA1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
5923	Microtubule-associated protein tau	MAPT	0.0018
5924	Microtubule-associated protein 4	MAP4	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
4122	Histone deacetylase 2	HDAC2	0.0018
3168	Beta-lactamase OXA-1	bla	0.0018
4819	Hydrolase	Not Available	0.0018
5249	Hydrolase	Not Available	0.0018
5436	Hydrolase	Not Available	0.0018
3230	Non-ATP-dependent L-selective hydantoinase	lhyD	0.0018
3122	D-hydantoinase	Not Available	0.0018
3145	D-hydantoinase	hyuA	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
275	Arachidonate 5-lipoxygenase	ALOX5	0.0017
16	Adenosine A1 receptor	ADORA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
131	Synaptic vesicular amine transporter	SLC18A2	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
2840	Beta-lactamase IMP-1	Not Available	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
6174	50S ribosomal protein L32	rpmF	0.0016
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
1123	Eosinophil cationic protein	RNASE3	0.0016
3233	Bile acid receptor	NR1H4	0.0015
3873	Prolyl endopeptidase	PREP	0.0015
6928	Prolyl endopeptidase	Not Available	0.0015
4192	DNA topoisomerase 2-beta	TOP2B	0.0015
3237	Beta-lactamase OXA-2	bla	0.0015
3292	Alanine racemase, catabolic	dadX	0.0015
3281	Isoaspartyl dipeptidase	iadA	0.0015
4264	Alpha-L-fucosidase, putative	TM_0306	0.0015
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0015
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
3809	Estrogen-related receptor gamma	ESRRG	0.0015
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0014
1541	Metalloproteinase	mmp20	0.0014
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0014
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0014
2801	UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase	murE	0.0014
2983	Methylmalonyl-CoA carboxyltransferase 5S subunit	Not Available	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
183	Vascular endothelial growth factor A	VEGFA	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0014
4549	Endonuclease III	HP_0602	0.0013
2646	Dihydroorotase	pyrC	0.0013
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
921	Glutamate receptor 2	GRIA2	0.0013
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0013
3810	Catechol O-methyltransferase	COMT	0.0013
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0013
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0013
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0013
5591	Complement component C8 gamma chain	C8G	0.0013
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0013
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0013
2838	Ribose-5-phosphate isomerase A	rpiA	0.0013
2952	Ribose-5-phosphate isomerase A	rpiA	0.0013
5595	Ribose-5-phosphate isomerase A	rpiA	0.0013
4695	UPF0124 protein yfiH	yfiH	0.0013
5590	N utilization substance protein B homolog	nusB	0.0013
5588	Cell division protein FtsY	TM_0570	0.0013
4375	Glutamine synthetase 1	glnA1	0.0013
5587	Iron(III)-binding periplasmic protein	fbpA	0.0013
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0013
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0013
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0013
5593	Transferase	Not Available	0.0013
5581	Beta-fructosidase	bfrA	0.0013
5060	Intron-associated endonuclease 1	ITEVIR	0.0013
5575	Short tail fiber protein	12	0.0013
5600	Pyruvate decarboxylase	pdc	0.0013
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0013
2717	Folylpolyglutamate synthase	fgs	0.0013
5580	Hexon protein	PII	0.0013
5574	Invasin	YPTB1668	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
2340	Beta-lactamase PSE-2	bla	0.0012
2796	Parathion hydrolase	opd	0.0012
6539	Parathion hydrolase	opd	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
4992	Cytochrome c peroxidase	Not Available	0.0012
3957	Adenosine deaminase	ADA	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
6859	Protein S100-A4	S100A4	0.0012
894	Alanine racemase	alr	0.0012
2453	Alanine racemase	alr	0.0012
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0012
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0012
7	Nitric oxide synthase, inducible	NOS2	0.0011
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0011
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0011
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
5328	Prostaglandin F synthase	Tb11.02.2310	0.0011
3729	Citrate synthase	gltA	0.0011
4575	Citrate synthase	cit	0.0011
4580	Citrate synthase	gltA	0.0011
5006	RNASE4 protein	RNASE4	0.0011
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
6459	Glycodelin	PAEP	0.0011
4311	tRNA	TRDMT1	0.0011
4325	tRNA	trmD	0.0011
4328	tRNA	trmD	0.0011
1630	Integrin beta-2	ITGB2	0.0011
687	Tyrosine-protein phosphatase non-receptor type 1	PTPN1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
976	Platelet glycoprotein IX	GP9	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
908	Glutathione S-transferase theta-1	GSTT1	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.001
2603	Beta-lactamase II	blm	0.001
3583	6-phosphogluconolactonase	pgl	0.001
2149	Angiogenin	ANG	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
4217	Telomerase reverse transcriptase	TERT	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.001
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.001
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.001
2286	Isocitrate dehydrogenase [NADP]	icd	0.001
2302	Isocitrate dehydrogenase [NADP]	icd	0.001
2771	Isocitrate dehydrogenase [NADP]	icd	0.001
3486	Fumarate hydratase class II	fumC	0.001
2942	Sialidase	nanH	0.001
3546	Sialidase	nedA	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
162	Retinoic acid receptor gamma-1	RARG	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
174	Sigma 1-type opioid receptor	SIGMAR1	0.0009
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0009
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
164	Histamine H4 receptor	HRH4	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
1757	Myeloperoxidase	MPO	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
84	Nuclear receptor 0B1	NR0B1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
857	Malate dehydrogenase, mitochondrial	MDH2	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
332	Beta-lactamase	blaZ	0.0009
2478	Beta-lactamase	ampC	0.0009
2613	Beta-lactamase	ampC	0.0009
2635	Beta-lactamase	ampC	0.0009
2700	Beta-lactamase	penP	0.0009
5445	Beta-lactamase	blaB	0.0009
6019	Beta-lactamase	SHV-7	0.0009
6701	Beta-lactamase	cphA	0.0009
2697	Uridine-cytidine kinase 2	UCK2	0.0009
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
6044	Serum paraoxonase/lactonase 3	PON3	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
94	5-hydroxytryptamine 4 receptor	HTR4	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
572	Integrin alpha-L	ITGAL	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
1867	Major prion protein	PRNP	0.0008
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
411	Glycine N-methyltransferase	GNMT	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
291	Nitric-oxide synthase, endothelial	NOS3	0.0008
760	Fibroblast growth factor 1	FGF1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6146	High affinity copper uptake protein 1	SLC31A1	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
128	Adenine phosphoribosyltransferase	APRT	0.0007
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0007
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2207	Rhodopsin	RHO	0.0007
5934	Cytochrome P450 26A1	CYP26A1	0.0007
6218	Pannexin-1	PANX1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
751	Potassium channel subfamily K member 6	KCNK6	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3587	Gastrotropin	FABP6	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
125	DNA polymerase beta	POLB	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
3937	Fatty-acid amide hydrolase	FAAH	0.0006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0006
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0006
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0006
5682	Ribonuclease pancreatic	RNASE1	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
822	Aldose reductase	AKR1B1	0.0006
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0006
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0006
172	Potassium channel subfamily K member 1	KCNK1	0.0006
33	Cystine/glutamate transporter	SLC7A11	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
563	Thyroid peroxidase	TPO	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0006
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
5626	Nucleoside diphosphate kinase B	NME2	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2021	Thrombomodulin	THBD	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
517	Alcohol dehydrogenase 1C	ADH1C	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
1992	Vitamin D-binding protein	GC	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0004
2802	Endoglucanase G	celCCG	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
1650	Heme carrier protein 1	SLC46A1	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0002
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB06616 - Bosutinib

Targets

Enzymes

Transporters

Predictions