DT-Web: DB08896

Identification

Name

Regorafenib

Accession Number

DB08896

Type

small molecule

Description

Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer and advanced gastrointestinal stromal tumours. FDA approved on September 27, 2012.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

482.815

Groups

approved

Monoisotopic Weight

482.076880893

Pharmacology

Indication

Regorafenib is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy. Regorafenib is also indicated for the treatment of patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate.

Mechanism of action

Regorafenib is a small molecule inhibitor of multiple membrane-bound and intracellular kinases involved in normal cellular functions and in pathologic processes such as oncogenesis, tumor angiogenesis, and maintenance of the tumor microenvironment. In in vitro biochemical or cellular assays, regorafenib or its major human active metabolites M-2 and M-5 inhibited the activity of RET, VEGFR1, VEGFR2, VEGFR3, KIT, PDGFR-alpha, PDGFR-beta, FGFR1, FGFR2, TIE2, DDR2, TrkA, Eph2A, RAF-1, BRAF, BRAFV600E , SAPK2, PTK5, and Abl at concentrations of regorafenib that have been achieved clinically. In in vivo models, regorafenib demonstrated anti-angiogenic activity in a rat tumor model, and inhibition of tumor growth as well as anti-metastatic activity in several mouse xenograft models including some for human colorectal carcinoma.

Absorption

Cmax = 2.5 ?g/mL; Tmax = 4 hours; AUC = 70.4 ?g*h/mL; Cmax, steady-state = 3.9 ?g/mL; AUC, steady-state = 58.3 ?g*h/mL; The mean relative bioavailability of tablets compared to an oral solution is 69% to 83%.

Protein binding

Regorafenib is highly bound (99.5%) to human plasma proteins.

Biotransformation

Regorafenib is metabolized by CYP3A4 and UGT1A9. The main circulating metabolites of regorafenib measured at steady-state in human plasma are M-2 (N-oxide) and M-5 (N-oxide and N-desmethyl), both of them having similar in vitro pharmacological activity and steady-state concentrations as regorafenib. M-2 and M-5 are highly protein bound (99.8% and 99.95%, respectively).

Route of elimination

Approximately 71% of a radiolabeled dose was excreted in feces (47% as parent compound, 24% as metabolites) and 19% of the dose was excreted in urine (17% as glucuronides) within 12 days after administration of a radiolabeled oral solution at a dose of 120 mg.

Toxicity

The most common adverse reactions (>=20%) are asthenia/fatigue, HFSR, diarrhea, decreased appetite/food intake, hypertension, mucositis, dysphonia, and infection, pain (not otherwise specified), decreased weight, gastrointestinal and abdominal pain, rash, fever, and nausea

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Carbamazepine	Strong CYP3A4 inducers may decrease levels of regorafenib.
Clarithromycin	Strong CYP3A4 inhibitors may increase levels of regorafenib.
Irinotecan	Regorafenib may increase levels of irinotecan, a UGT1A1 substrate.
Itraconazole	Strong CYP3A4 inhibitors may increase levels of regorafenib.
Ketoconazole	Strong CYP3A4 inhibitors may increase levels of regorafenib.
Phenobarbital	Strong CYP3A4 inducers may decrease levels of regorafenib.
Phenytoin	Strong CYP3A4 inducers may decrease levels of regorafenib.
Posaconazole	Strong CYP3A4 inhibitors may increase levels of regorafenib.
Rifampin	Strong CYP3A4 inducers may decrease levels of regorafenib.
St. John's Wort	Strong CYP3A4 inducers may decrease levels of regorafenib.
Telithromycin	Strong CYP3A4 inhibitors may increase levels of regorafenib.
Voriconazole	Strong CYP3A4 inhibitors may increase levels of regorafenib.

Food Interactions

When taken with a high-fat meal, AUC increased by 48% and decreased mean AUC of M2 and M5 metabolites by 20% and 51% respectively.

Proto-oncogene tyrosine-protein kinase receptor ret
Name	Proto-oncogene tyrosine-protein kinase receptor ret
Gene Name	RET
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.9684
Vascular endothelial growth factor receptor 1
Name	Vascular endothelial growth factor receptor 1
Gene Name	FLT1
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.8559
Vascular endothelial growth factor receptor 2
Name	Vascular endothelial growth factor receptor 2
Gene Name	KDR
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	1.7843
Vascular endothelial growth factor receptor 3
Name	Vascular endothelial growth factor receptor 3
Gene Name	FLT4
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.5764
Mast/stem cell growth factor receptor
Name	Mast/stem cell growth factor receptor
Gene Name	KIT
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.678
Alpha platelet-derived growth factor receptor
Name	Alpha platelet-derived growth factor receptor
Gene Name	PDGFRA
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.68
Beta platelet-derived growth factor receptor
Name	Beta platelet-derived growth factor receptor
Gene Name	PDGFRB
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.6902
Basic fibroblast growth factor receptor 1
Name	Basic fibroblast growth factor receptor 1
Gene Name	FGFR1
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	1.436
Fibroblast growth factor receptor 2
Name	Fibroblast growth factor receptor 2
Gene Name	FGFR2
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	1.0002
Angiopoietin-1 receptor
Name	Angiopoietin-1 receptor
Gene Name	TEK
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.8922
Discoidin domain-containing receptor 2
Name	Discoidin domain-containing receptor 2
Gene Name	Not Available
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	Not Available
High affinity nerve growth factor receptor
Name	High affinity nerve growth factor receptor
Gene Name	NTRK1
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.288
Ephrin type-A receptor 2
Name	Ephrin type-A receptor 2
Gene Name	EPHA2
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.3098
RAF proto-oncogene serine/threonine-protein kinase
Name	RAF proto-oncogene serine/threonine-protein kinase
Gene Name	RAF1
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.452
B-Raf proto-oncogene serine/threonine-protein kinase
Name	B-Raf proto-oncogene serine/threonine-protein kinase
Gene Name	BRAF
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	1.2186
Mitogen-activated protein kinase 11
Name	Mitogen-activated protein kinase 11
Gene Name	MAPK11
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	0.3298
Tyrosine-protein kinase FRK
Name	Tyrosine-protein kinase FRK
Gene Name	Not Available
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	Not Available
Proto-oncogene tyrosine-protein kinase ABL1
Name	Proto-oncogene tyrosine-protein kinase ABL1
Gene Name	ABL1
Pharmacological action	yes
Actions	inhibitor
References	FDA label -
DTHybrid score	1.088

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	FDA label -
DTHybrid score	0.9902
UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Actions	substrate,inhibitor
References	FDA label -
DTHybrid score	0.4475
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	FDA label -
DTHybrid score	0.6299
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	FDA label -
DTHybrid score	0.7375
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inhibitor
References	FDA label -
DTHybrid score	0.4837
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	FDA label -
DTHybrid score	0.6296
UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	inhibitor
References	FDA label -
DTHybrid score	0.4968

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	FDA label -
DTHybrid score	0.7951
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	FDA label -
DTHybrid score	0.6466

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.4587
4200	Cytochrome P450 1A2	CYP1A2	0.4425
4118	Cytochrome P450 3A5	CYP3A5	0.4383
3856	Fibroblast growth factor receptor 3	FGFR3	0.301
165	FL cytokine receptor	FLT3	0.2767
6107	Cytochrome P450 3A7	CYP3A7	0.2656
2599	Tyrosine-protein kinase HCK	HCK	0.2234
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.222
2216	Fibroblast growth factor receptor 4	FGFR4	0.2207
587	Serum albumin	ALB	0.205
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1988
20	Prostaglandin G/H synthase 1	PTGS1	0.1872
1128	Alpha-2-macroglobulin	A2M	0.1817
6013	Cytochrome P450 2E1	CYP2E1	0.1768
6024	Cytochrome P450 1A1	CYP1A1	0.1571
2164	Multidrug resistance-associated protein 4	ABCC4	0.1478
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.1414
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1412
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.1371
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.1278
5718	Cytochrome P450 2A6	CYP2A6	0.1255
862	Multidrug resistance-associated protein 1	ABCC1	0.1236
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1219
1585	Basement membrane-specific heparan sulfate proteoglycan core protein	HSPG2	0.1213
6824	Tyrosine-protein kinase Lyn	LYN	0.1199
3852	Neuropilin-1	NRP1	0.1056
290	Prostaglandin G/H synthase 2	PTGS2	0.1048
1729	Solute carrier family 22 member 6	SLC22A6	0.1032
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0993
776	Bile salt export pump	ABCB11	0.097
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.093
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0919
1898	Cytochrome P450 1B1	CYP1B1	0.0846
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0839
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.083
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0803
6106	Cytochrome P450 2C18	CYP2C18	0.0798
6142	Solute carrier family 22 member 8	SLC22A8	0.0751
1144	Hepatocyte growth factor receptor	MET	0.0709
760	Fibroblast growth factor 1	FGF1	0.069
6145	Solute carrier family 22 member 1	SLC22A1	0.0675
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0655
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0654
6144	Solute carrier family 22 member 2	SLC22A2	0.0651
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0649
1864	RET proto-oncogene	RET	0.064
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0638
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0637
844	Epidermal growth factor receptor	EGFR	0.0623
824	Sodium-dependent serotonin transporter	SLC6A4	0.0618
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0614
492	Histamine H1 receptor	HRH1	0.0606
484	Tyrosine-protein kinase ABL2	ABL2	0.0591
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.054
3811	Cytochrome P450 19A1	CYP19A1	0.0528
467	Delta-type opioid receptor	OPRD1	0.051
696	Kappa-type opioid receptor	OPRK1	0.0499
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0463
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0458
847	Mu-type opioid receptor	OPRM1	0.0456
3810	Catechol O-methyltransferase	COMT	0.0441
136	Estrogen receptor	ESR1	0.0437
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0436
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0427
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0421
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0418
556	Alpha-1A adrenergic receptor	ADRA1A	0.0417
183	Vascular endothelial growth factor A	VEGFA	0.0401
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0373
4604	Liver carboxylesterase 1	CES1	0.0373
731	HIV-1 protease	HIV-1 protease	0.0369
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0352
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.035
871	Glucocorticoid receptor	NR3C1	0.0348
6143	Solute carrier family 22 member 7	SLC22A7	0.0345
831	D(2) dopamine receptor	DRD2	0.0345
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0344
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0337
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0337
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0335
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0321
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0317
146	Androgen receptor	AR	0.0316
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0315
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0311
6102	Arylamine N-acetyltransferase 2	NAT2	0.031
6137	Multidrug resistance-associated protein 6	ABCC6	0.0309
260	Cytochrome P450 51	ERG11	0.0308
761	Cytochrome P450 51	ERG11	0.0308
3163	Cytochrome P450 51	cyp51	0.0308
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0307
766	Beta-2 adrenergic receptor	ADRB2	0.0305
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0303
777	Tumor necrosis factor	TNF	0.0301
1024	Solute carrier family 22 member 11	SLC22A11	0.0297
318	Alpha-2A adrenergic receptor	ADRA2A	0.0297
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0296
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0295
6147	Solute carrier family 22 member 3	SLC22A3	0.0292
468	Cytochrome P450 4A11	CYP4A11	0.0292
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0288
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0287
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0286
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0286
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0286
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0285
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0282
713	Sodium-dependent dopamine transporter	SLC6A3	0.0277
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0274
817	DNA topoisomerase 2-alpha	TOP2A	0.0271
122	P2Y purinoceptor 12	P2RY12	0.0268
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0266
6026	Alcohol dehydrogenase 6	ADH6	0.0266
1353	DNA topoisomerase 1	TOP1	0.0266
3552	DNA topoisomerase 1	topA	0.0266
118	Organic cation/carnitine transporter 2	SLC22A5	0.0265
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0258
3923	Cholinesterase	BCHE	0.0254
789	Alpha-1D adrenergic receptor	ADRA1D	0.0254
6148	Multidrug resistance-associated protein 7	ABCC10	0.0251
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0242
891	Dihydropteroate synthase	folP	0.0237
5359	Dihydropteroate synthase	folP	0.0237
7175	Dihydropteroate synthase	sulI	0.0237
3941	Amine oxidase [flavin-containing] A	MAOA	0.0236
6031	Cytochrome P450 3A43	CYP3A43	0.0235
70	Type-1 angiotensin II receptor	AGTR1	0.0234
465	Calmodulin	CALM1	0.0234
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0232
632	Alpha-1B adrenergic receptor	ADRA1B	0.0232
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0226
4120	NADPH--cytochrome P450 reductase	POR	0.0225
6182	Cytochrome P450 2J2	CYP2J2	0.0224
23	D(1A) dopamine receptor	DRD1	0.022
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0219
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0216
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0215
6141	Sodium/bile acid cotransporter	SLC10A1	0.0213
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0213
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0212
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.021
6136	Multidrug resistance-associated protein 5	ABCC5	0.0207
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0207
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0204
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0203
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.02
738	Monocarboxylate transporter 1	SLC16A1	0.0197
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0194
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0193
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0192
869	Estrogen receptor beta	ESR2	0.0192
3866	Serum amyloid A protein	SAA1	0.019
1200	AMBP protein	AMBP	0.019
1932	Apolipoprotein E	APOE	0.019
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.019
1757	Myeloperoxidase	MPO	0.0189
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0187
6085	Fatty acid-binding protein, intestinal	FABP2	0.0187
193	Beta-1 adrenergic receptor	ADRB1	0.0186
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0184
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0178
275	Arachidonate 5-lipoxygenase	ALOX5	0.0178
3939	Amine oxidase [flavin-containing] B	MAOB	0.0176
756	Sex hormone-binding globulin	SHBG	0.0173
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0172
29	Tubulin beta-1 chain	TUBB1	0.017
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0169
811	Translocator protein	TSPO	0.0165
6220	Aryl hydrocarbon receptor	AHR	0.0164
319	Opioid receptor, sigma 1	OPRS1	0.0163
1192	Sulfotransferase 1A1	SULT1A1	0.0162
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0162
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0161
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.016
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0158
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0158
5880	Thrombopoietin receptor	MPL	0.0153
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0153
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0152
638	D(3) dopamine receptor	DRD3	0.0152
4192	DNA topoisomerase 2-beta	TOP2B	0.0152
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0152
833	Organic cation/carnitine transporter 1	SLC22A4	0.0152
614	Progesterone receptor	PGR	0.0151
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0151
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0151
117	Sterol O-acyltransferase 1	SOAT1	0.015
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0148
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0148
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0146
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0146
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0146
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0146
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0146
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0146
5646	Galactokinase	GALK1	0.0146
5302	TrwB	trwB	0.0146
5265	FtsH	ftsH	0.0145
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0144
161	Tubulin beta chain	TUBB	0.0142
312	Tubulin beta chain	TUB2	0.0142
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0141
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.014
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0138
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0137
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0136
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0136
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0136
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0136
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0136
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0134
5641	Rod shape-determining protein MreB	TM_0588	0.0134
3794	Osmolarity sensor protein envZ	envZ	0.0134
4178	DNA repair protein RAD51 homolog 1	RAD51	0.0134
5649	Potassium-transporting ATPase B chain	kdpB	0.0134
5644	Sensor protein phoQ	phoQ	0.0134
5643	General secretion pathway protein E	epsE	0.0134
5642	Chaperone clpB	clpB	0.0134
5645	DNA topoisomerase 4 subunit B	parE	0.0134
6227	DNA topoisomerase 4 subunit B	parE	0.0134
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0134
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0133
124	Histamine H2 receptor	HRH2	0.0133
373	Transthyretin	TTR	0.0133
5312	Kinesin-like protein KIF1A	KIF1A	0.0131
818	50S ribosomal protein L10	rplJ	0.013
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0129
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
380	Cytochrome P450 17A1	CYP17A1	0.0126
952	Dipeptidyl peptidase 4	DPP4	0.0126
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0123
2615	Chemotaxis protein cheA	cheA	0.0122
2371	Pantothenate kinase	coaA	0.0122
2892	Acetylglutamate kinase	argB	0.0122
3550	Acetylglutamate kinase	argB	0.0122
1881	Hexokinase-1	HK1	0.0122
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0122
2852	DNA mismatch repair protein mutL	mutL	0.0121
2539	Tubulin alpha-1 chain	TUBA4A	0.0118
2867	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	ispE	0.0117
6433	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	PFKFB4	0.0116
2397	Dihydroxyacetone kinase	dhaK	0.0116
4751	Mitogen-activated protein kinase 12	MAPK12	0.0116
2727	S-adenosylmethionine synthetase	metK	0.0116
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0115
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0114
4773	Deoxycytidine kinase	DCK	0.0114
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0113
6103	Arylamine N-acetyltransferase 1	NAT1	0.0113
273	Apoptosis regulator Bcl-2	BCL2	0.0112
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0112
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0112
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0111
3809	Estrogen-related receptor gamma	ESRRG	0.0111
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0111
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0111
1656	CYP2B protein	CYP2B	0.0109
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0108
3231	Death-associated protein kinase 1	DAPK1	0.0108
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0107
2299	UDP-N-acetylmuramate--L-alanine ligase	murC	0.0107
427	Substance-P receptor	TACR1	0.0106
1275	Estrogen sulfotransferase	SULT1E1	0.0105
365	Dihydrofolate reductase	DHFR	0.0105
2381	Dihydrofolate reductase	DFR1	0.0105
2833	Dihydrofolate reductase	Not Available	0.0105
2931	Dihydrofolate reductase	folA	0.0105
3544	Dihydrofolate reductase	folA	0.0105
3682	Dihydrofolate reductase	folA	0.0105
6642	Dihydrofolate reductase	folA	0.0105
6756	Dihydrofolate reductase	dfrA	0.0105
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0105
904	Glutathione S-transferase P	GSTP1	0.0105
1010	Cytochrome P450 51A1	CYP51A1	0.0105
629	Alpha-2B adrenergic receptor	ADRA2B	0.0105
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0104
33	Cystine/glutamate transporter	SLC7A11	0.0103
2240	Cell division protein kinase 2	CDK2	0.0102
1050	Bile salt sulfotransferase	SULT2A1	0.0102
174	Sigma 1-type opioid receptor	SIGMAR1	0.0102
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0102
54	Prothrombin	F2	0.0101
908	Glutathione S-transferase theta-1	GSTT1	0.0099
2251	Thymidylate kinase	tmk	0.0099
2254	Thymidylate kinase	DTYMK	0.0099
3522	Thymidylate kinase	tmk	0.0099
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0099
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0099
723	Cytosolic phospholipase A2	PLA2G4A	0.0098
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0098
887	DNA gyrase subunit B	gyrB	0.0098
4150	DNA gyrase subunit B	gyrB	0.0098
6225	DNA gyrase subunit B	gyrB	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
489	Monocarboxylate transporter 2	SLC16A7	0.0097
3947	Xanthine dehydrogenase/oxidase	XDH	0.0097
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0097
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0096
49	Endothelin B receptor	EDNRB	0.0096
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0095
958	Insulin-like growth factor 1 receptor	IGF1R	0.0095
207	Glutathione synthetase	GSS	0.0095
5269	Glutathione synthetase	gshB	0.0095
68	Cannabinoid receptor 1	CNR1	0.0094
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0094
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0093
482	Glycine receptor subunit alpha-1	GLRA1	0.0093
992	Protein tyrosine kinase 2 beta	PTK2B	0.0092
3822	Actin, alpha skeletal muscle	ACTA1	0.0092
24	Thymidylate synthase	TMP1	0.0092
359	Thymidylate synthase	TYMS	0.0092
2626	Thymidylate synthase	thyA	0.0092
2729	Thymidylate synthase	thyA	0.0092
5352	Thymidylate synthase	THYA	0.0092
716	5-hydroxytryptamine 7 receptor	HTR7	0.0091
232	Corticosteroid-binding globulin	SERPINA6	0.0091
6014	Cytochrome P450 2A13	CYP2A13	0.0091
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
592	Carbonic anhydrase 4	CA4	0.009
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0089
5300	Antigen peptide transporter 1	TAP1	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0088
459	Retinoic acid receptor RXR-alpha	RXRA	0.0088
295	Carbonic anhydrase 1	CA1	0.0087
267	Plasminogen activator inhibitor 1	SERPINE1	0.0087
2021	Thrombomodulin	THBD	0.0087
737	Mineralocorticoid receptor	NR3C2	0.0086
921	Glutamate receptor 2	GRIA2	0.0086
6138	Multidrug resistance protein 3	ABCB4	0.0086
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0085
1630	Integrin beta-2	ITGB2	0.0085
1760	Aminopeptidase N	ANPEP	0.0085
6843	Aminopeptidase N	pepN	0.0085
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0084
474	Acetylcholinesterase	ACHE	0.0084
6043	Putative G-protein coupled receptor 44	GPR44	0.0084
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0084
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0083
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
6146	High affinity copper uptake protein 1	SLC31A1	0.0081
1852	Microtubule-associated protein 2	MAP2	0.0081
6221	Steroid hormone receptor ERR1	ESRRA	0.0081
378	Alpha-2C adrenergic receptor	ADRA2C	0.0081
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
469	Annexin A1	ANXA1	0.0079
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0079
6020	Aldehyde oxidase	AOX1	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0078
2616	Ganglioside GM2 activator	GM2A	0.0078
3937	Fatty-acid amide hydrolase	FAAH	0.0078
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
1836	Mitogen-activated protein kinase 10	MAPK10	0.0076
2236	Casein kinase II subunit alpha	CSNK2A1	0.0076
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0074
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0074
1541	Metalloproteinase	mmp20	0.0074
94	5-hydroxytryptamine 4 receptor	HTR4	0.0073
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0073
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0073
4122	Histone deacetylase 2	HDAC2	0.0072
88	Retinoic acid receptor RXR-beta	RXRB	0.0072
432	D(4) dopamine receptor	DRD4	0.0072
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0071
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.007
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.007
705	Glutamate receptor 1	GRIA1	0.007
284	DNA-directed RNA polymerase beta chain	rpoB	0.007
5773	DNA-directed RNA polymerase beta chain	rpoB	0.007
239	Coagulation factor X	F10	0.007
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0068
244	Angiotensin-converting enzyme	ACE	0.0068
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0068
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0068
106	Cannabinoid receptor 2	CNR2	0.0068
357	Carbonic anhydrase 2	CA2	0.0067
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0066
856	Vitamin D3 receptor	VDR	0.0066
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0066
6500	Phospholipase A2	PLA2G1B	0.0066
340	Apoptotic protease-activating factor 1	APAF1	0.0065
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0065
768	FK506-binding protein 1A	FKBP1A	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
84	Nuclear receptor 0B1	NR0B1	0.0063
4237	50S ribosomal protein L22	rplV	0.0062
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0062
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0062
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0061
4203	Histamine N-methyltransferase	HNMT	0.0061
5923	Microtubule-associated protein tau	MAPT	0.006
5924	Microtubule-associated protein 4	MAP4	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
1792	Tissue-type plasminogen activator	PLAT	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
3932	Glutathione S-transferase A2	GSTA2	0.006
132	ATP-binding cassette sub-family A member 1	ABCA1	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0059
6042	Prostaglandin reductase 2	PTGR2	0.0059
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0059
6044	Serum paraoxonase/lactonase 3	PON3	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
581	Cytochrome P450 2R1	CYP2R1	0.0058
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0057
6163	Copper-transporting ATPase 2	ATP7B	0.0057
6165	Copper-transporting ATPase 1	ATP7A	0.0057
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
4210	Toll-like receptor 4	TLR4	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0055
780	Retinoic acid receptor RXR-gamma	RXRG	0.0055
1039	Histone deacetylase 9	HDAC9	0.0055
6174	50S ribosomal protein L32	rpmF	0.0055
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0055
814	Ryanodine receptor 1	RYR1	0.0055
896	Glutathione S-transferase Mu 1	GSTM1	0.0055
572	Integrin alpha-L	ITGAL	0.0055
558	Solute carrier family 12 member 1	SLC12A1	0.0054
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0054
1629	Transcription factor AP-1	JUN	0.0054
7	Nitric oxide synthase, inducible	NOS2	0.0054
477	DNA topoisomerase 4 subunit A	parC	0.0054
886	DNA topoisomerase 4 subunit A	parC	0.0054
6226	DNA topoisomerase 4 subunit A	parC	0.0054
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0054
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0053
404	DNA gyrase subunit A	gyrA	0.0053
6224	DNA gyrase subunit A	gyrA	0.0053
1650	Heme carrier protein 1	SLC46A1	0.0053
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0052
4103	Proteasome subunit beta type 2	PSMB2	0.0052
4102	Proteasome subunit beta type 5	PSMB5	0.0052
4101	Proteasome subunit beta type 1	PSMB1	0.0052
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0052
6126	Carbonic anhydrase 7	CA7	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
4217	Telomerase reverse transcriptase	TERT	0.0051
6755	Poliovirus receptor	PVR	0.0051
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0051
461	Glycine receptor subunit alpha-3	GLRA3	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
6149	Solute carrier family 22 member 10	SLC22A10	0.005
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
518	Peroxidase/catalase T	katG	0.005
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0049
1178	Adenosine A2a receptor	ADORA2A	0.0049
6432	Transporter	snf	0.0049
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0049
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0047
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0047
4238	50S ribosomal protein L4	rplD	0.0047
5578	50S ribosomal protein L4	rplD	0.0047
6173	50S ribosomal protein L4	rplD	0.0047
6219	50S ribosomal protein L4	rplD	0.0047
4692	A/G-specific adenine glycosylase	mutY	0.0047
563	Thyroid peroxidase	TPO	0.0047
162	Retinoic acid receptor gamma-1	RARG	0.0047
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0047
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0047
683	Potassium transporter	GK0582	0.0047
1648	Elastin	ELN	0.0046
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0046
1313	Lactoylglutathione lyase	GLO1	0.0045
6228	Nuclear receptor coactivator 1	NCOA1	0.0045
1992	Vitamin D-binding protein	GC	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
292	Activin receptor type-1	ACVR1	0.0044
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
849	Activated CDC42 kinase 1	TNK2	0.0044
702	UMP-CMP kinase	CMPK1	0.0044
1196	Complement decay-accelerating factor	CD55	0.0044
1262	Corticotropin-lipotropin	POMC	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
163	D(1B) dopamine receptor	DRD5	0.0043
1483	Membrane copper amine oxidase	AOC3	0.0043
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0043
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0042
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0042
395	ALK tyrosine kinase receptor	Not Available	0.0042
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0042
733	Activin receptor type 1B	ACVR1B	0.0042
825	Arsenical pump-driving ATPase	ASNA1	0.0042
3435	Arsenical pump-driving ATPase	arsA	0.0042
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0042
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0042
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0042
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0042
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0042
154	AFG3-like protein 2	AFG3L2	0.0042
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0042
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0042
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0042
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0041
394	Calcineurin subunit B isoform 1	PPP3R1	0.0041
6753	Apolipoprotein M	APOM	0.0041
6742	Recoverin	RCVRN	0.0041
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0041
6747	Chalcone/stilbene synthase family protein	MT1417	0.0041
6743	Non-fluorescent flavoprotein	luxF	0.0041
2528	Fatty acid metabolism regulator protein	fadR	0.0041
6740	Fatty acid metabolism regulator protein	fadR	0.0041
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0041
6751	Gag polyprotein	gag	0.0041
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0041
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0041
6749	Polyprotein	Not Available	0.0041
16	Adenosine A1 receptor	ADORA1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3679	MTA/SAH nucleosidase	mtnN	0.004
3868	Calcineurin subunit B isoform 2	PPP3R2	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.004
2320	Thymidine kinase, cytosolic	TK1	0.004
2297	Genome polyprotein	Not Available	0.004
2322	Genome polyprotein	Not Available	0.004
2694	Genome polyprotein	Not Available	0.004
2719	Genome polyprotein	Not Available	0.004
2860	Genome polyprotein	Not Available	0.004
2928	Genome polyprotein	Not Available	0.004
3160	Genome polyprotein	Not Available	0.004
3260	Genome polyprotein	Not Available	0.004
4783	Genome polyprotein	Not Available	0.004
5726	Genome polyprotein	Not Available	0.004
5779	Genome polyprotein	Not Available	0.004
5867	Genome polyprotein	Not Available	0.004
6253	Genome polyprotein	Not Available	0.004
6301	Genome polyprotein	Not Available	0.004
6380	Genome polyprotein	Not Available	0.004
6381	Genome polyprotein	Not Available	0.004
6437	Genome polyprotein	Not Available	0.004
6520	Genome polyprotein	Not Available	0.004
6521	Genome polyprotein	Not Available	0.004
6652	Genome polyprotein	Not Available	0.004
6734	Genome polyprotein	Not Available	0.004
6735	Genome polyprotein	Not Available	0.004
6736	Genome polyprotein	Not Available	0.004
6737	Genome polyprotein	Not Available	0.004
6738	Genome polyprotein	Not Available	0.004
6739	Genome polyprotein	Not Available	0.004
6744	Genome polyprotein	Not Available	0.004
6748	Genome polyprotein	Not Available	0.004
6894	Genome polyprotein	Not Available	0.004
6898	Genome polyprotein	Not Available	0.004
4311	tRNA	TRDMT1	0.004
4325	tRNA	trmD	0.004
4328	tRNA	trmD	0.004
634	Squalene monooxygenase	SQLE	0.004
7196	Squalene monooxygenase	ERG1	0.004
775	Acetyl-CoA carboxylase 2	ACACB	0.004
1256	5-hydroxytryptamine 6 receptor	HTR6	0.004
1129	C-C chemokine receptor type 5	CCR5	0.0039
131	Synaptic vesicular amine transporter	SLC18A2	0.0039
128	Adenine phosphoribosyltransferase	APRT	0.0038
2808	Chloramphenicol acetyltransferase 3	cat3	0.0038
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0038
85	Growth hormone receptor	GHR	0.0038
594	Thyroxine-binding globulin	SERPINA7	0.0037
3639	Thymidine phosphorylase	deoA	0.0037
3936	Thymidine phosphorylase	TYMP	0.0037
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0037
6167	Organic solute transporter subunit beta	OSTB	0.0037
6166	Organic solute transporter subunit alpha	OSTA	0.0037
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0037
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0037
661	ADP/ATP translocase 1	SLC25A4	0.0037
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0037
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0037
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0037
297	Adenylate cyclase type 1	ADCY1	0.0037
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0036
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0036
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0036
5961	Insulin	INS	0.0036
976	Platelet glycoprotein IX	GP9	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
6527	Lymphocyte antigen 96	LY96	0.0036
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0035
3808	Dihydropteroate synthase 2	folP2	0.0035
3601	Dihydropteroate synthase 1	folP1	0.0035
3807	Dihydropteroate synthase 1	folP1	0.0035
2112	Toll-like receptor 9	TLR9	0.0035
2417	Chloramphenicol acetyltransferase	cat	0.0035
3278	Chloramphenicol acetyltransferase	cat	0.0035
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0035
6837	Serine/threonine-protein kinase 17B	STK17B	0.0035
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0035
2810	Dr hemagglutinin structural subunit	draA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
293	Gamma-glutamyl hydrolase	GGH	0.0035
153	Dopamine beta-hydroxylase	DBH	0.0035
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0034
758	Thyroid hormone receptor alpha	THRA	0.0034
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0034
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0034
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0034
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0033
6750	ADP-ribosylation factor 6	ARF6	0.0033
6021	Adenosine kinase	ADK	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0033
6524	Protein tonB	tonB	0.0033
4226	Uridine phosphorylase 2	UPP2	0.0033
5934	Cytochrome P450 26A1	CYP26A1	0.0032
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0032
229	Retinoic acid receptor beta	RARB	0.0032
6316	ADP-ribosylation factor 1	ARF1	0.0032
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0032
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0031
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0031
730	Retinoic acid receptor alpha	RARA	0.0031
1517	Beta-3 adrenergic receptor	ADRB3	0.0031
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0031
3086	Plasmepsin-2	Not Available	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
740	Argininosuccinate synthase	ASS1	0.0031
865	Argininosuccinate synthase	ASS1	0.0031
2680	Argininosuccinate synthase	argG	0.0031
3194	Argininosuccinate synthase	argG	0.0031
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0031
346	Thyroid hormone receptor beta-1	THRB	0.0031
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.003
4225	Uridine phosphorylase 1	UPP1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.003
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.003
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
291	Nitric-oxide synthase, endothelial	NOS3	0.003
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.003
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0029
444	Alcohol dehydrogenase 1B	ADH1B	0.0029
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
251	Alcohol dehydrogenase 1A	ADH1A	0.0029
5294	Nucleoside diphosphate kinase A	NME1	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
719	Retinoic acid receptor responder protein 1	RARRES1	0.0028
770	Retinoic acid-induced protein 3	GPRC5A	0.0028
605	Fumarate reductase flavoprotein subunit	frdA	0.0028
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0028
3673	Fumarate reductase flavoprotein subunit	fccA	0.0028
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0028
6549	Fumarate reductase flavoprotein subunit	frdA	0.0028
1291	cAMP response element-binding protein	CREB1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0028
413	Amidophosphoribosyltransferase	PPAT	0.0028
2515	Amidophosphoribosyltransferase	purF	0.0028
3714	Amidophosphoribosyltransferase	purF	0.0028
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0028
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0028
164	Histamine H4 receptor	HRH4	0.0028
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0028
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0027
820	Glycine receptor subunit alpha-2	GLRA2	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
199	Monocarboxylate transporter 8	SLC16A2	0.0027
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0027
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0027
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0027
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0027
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0027
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0027
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0027
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0027
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0027
864	Gag-Pol polyprotein	gag-pol	0.0026
2237	Gag-Pol polyprotein	gag-pol	0.0026
2326	Gag-Pol polyprotein	gag-pol	0.0026
2451	Gag-Pol polyprotein	gag-pol	0.0026
2901	Gag-Pol polyprotein	gag-pol	0.0026
3165	Gag-Pol polyprotein	gag-pol	0.0026
3722	Gag-Pol polyprotein	gag-pol	0.0026
6306	Gag-Pol polyprotein	gag-pol	0.0026
6624	Gag-Pol polyprotein	gag-pol	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
751	Potassium channel subfamily K member 6	KCNK6	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
5304	UPF0166 protein TM_0021	TM_0021	0.0025
5293	Shikimate kinase 2	aroL	0.0025
5266	Activator of	hgdC	0.0025
5287	Signaling protein	Not Available	0.0025
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0025
5292	Putative partitioning protein	TT_C1605	0.0025
3199	Phosphopantetheine adenylyltransferase	coaD	0.0025
3543	Phosphopantetheine adenylyltransferase	coaD	0.0025
3567	Phosphopantetheine adenylyltransferase	coaD	0.0025
5289	Phosphopantetheine adenylyltransferase	coaD	0.0025
5281	Plasmid segregation protein parM	parM	0.0025
2874	Nitrogenase iron protein 1	nifH1	0.0025
4346	Polynucleotide kinase	pseT	0.0025
5283	D-alanine--D-alanine ligase B	ddlB	0.0025
5288	Shikimate kinase	aroK	0.0025
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0025
5299	D-alanine--D-alanine ligase	ddl	0.0025
6598	D-alanine--D-alanine ligase	ddl	0.0025
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0025
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0025
5315	Chaperone protein htpG	htpG	0.0025
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0025
5259	Transcriptional regulator	ntrC1	0.0025
6699	Transcriptional regulator	Cgl2612	0.0025
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0025
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0025
5284	Large T antigen	Not Available	0.0025
5291	Glycogen synthase 1	glgA1	0.0025
5264	DNA replication protein	REP	0.0025
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0025
5285	Kinesin heavy chain	KIF5B	0.0025
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0025
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0025
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0025
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0025
5277	Preprotein translocase subunit secA	secA	0.0025
5308	Preprotein translocase secA 1 subunit	secA1	0.0025
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
3913	Glutamic acid decarboxylase	GAD65	0.0025
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0025
569	Retinal dehydrogenase 2	ALDH1A2	0.0025
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0025
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0025
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
517	Alcohol dehydrogenase 1C	ADH1C	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
172	Potassium channel subfamily K member 1	KCNK1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
2207	Rhodopsin	RHO	0.0024
6218	Pannexin-1	PANX1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
6048	Troponin C, skeletal muscle	TNNC2	0.0024
611	Retinal dehydrogenase 1	ALDH1A1	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
65	Matrix metalloproteinase-9	Not Available	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
6241	Nuclear receptor coactivator 2	NCOA2	0.0023
2427	Ferrichrome-iron receptor	fhuA	0.0023
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0023
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0023
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0023
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
6168	Solute carrier family 22 member 16	SLC22A16	0.0023
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0023
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0022
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
2091	Endoplasmin	HSP90B1	0.0022
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0022
2232	Interleukin-5	IL5	0.0022
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
735	Alanine aminotransferase 1	GPT	0.0021
3904	Alanine aminotransferase 2	GPT2	0.0021
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0021
3957	Adenosine deaminase	ADA	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
3470	Hypothetical protein MG245 homolog	MPN_348	0.0021
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0021
5189	Trimethylamine dehydrogenase	tmd	0.002
4106	Guanylate kinase	GUK1	0.002
4516	Guanylate kinase	gmk	0.002
4837	Cag-alfa	cag-alfa	0.002
4774	NTPase P4	Not Available	0.002
4839	DNA polymerase III subunit tau	dnaX	0.002
4838	PMS1 protein homolog 2	PMS2	0.002
2270	Dephospho-CoA kinase	coaE	0.002
2284	Adenylate kinase	adk	0.002
2296	Adenylate kinase	adk	0.002
2311	Adenylate kinase	adk	0.002
2312	Adenylate kinase	Not Available	0.002
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.002
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.002
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.002
3426	Glutamine synthetase	glnA	0.002
3987	Glutamine synthetase	GLUL	0.002
3175	Glutamate--cysteine ligase	gshA	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
5626	Nucleoside diphosphate kinase B	NME2	0.002
6459	Glycodelin	PAEP	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
1360	Sphingomyelin phosphodiesterase	SMPD1	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0019
2683	Mono-ADP-ribosyltransferase C3	C3	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
76	Nitric-oxide synthase, brain	NOS1	0.0019
5271	Focal adhesion kinase 1	PTK2	0.0018
2390	Nonsecretory ribonuclease	RNASE2	0.0018
1253	Interferon gamma	IFNG	0.0018
2922	Glycerol kinase	glpK	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
3587	Gastrotropin	FABP6	0.0017
268	Adenosine A2b receptor	ADORA2B	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0017
408	Riboflavin kinase	RFK	0.0017
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0017
2282	Protein recA	recA	0.0017
2315	Protein recA	recA	0.0017
2332	Protein recA	recA	0.0017
5263	Protein recA	recA	0.0017
3669	Ribokinase	rbsK	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
3830	Calreticulin	CALR	0.0017
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0017
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0017
1268	Neuropeptide S receptor	NPSR1	0.0017
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0017
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0016
788	Creatine kinase M-type	CKM	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
173	Toll-like receptor 7	TLR7	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
2697	Uridine-cytidine kinase 2	UCK2	0.0015
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
2334	Dethiobiotin synthetase	bioD	0.0015
6555	Dethiobiotin synthetase	bioD	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
6073	Potassium channel subfamily K member 9	KCNK9	0.0015
6072	Potassium channel subfamily K member 3	KCNK3	0.0015
6677	Myelin P2 protein	PMP2	0.0015
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0015
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0015
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
48	Pyridoxal kinase	PDXK	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0014
6395	Myosin-14	MYH14	0.0014
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0014
5818	Folate receptor alpha	FOLR1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
3221	Cytochrome c4	cc4	0.0014
1422	Serine/threonine-protein kinase 6	AURKA	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
3379	Kinesin-like protein KIF11	KIF11	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
509	Thymidine kinase	TK	0.0012
570	Thymidine kinase	TK	0.0012
2559	Thymidine kinase	TK	0.0012
3430	Thymidine kinase	tdk	0.0012
3518	Thymidine kinase	TK	0.0012
5301	Thymidine kinase	tdk	0.0012
5771	Thymidine kinase	ORF36	0.0012
7009	Thymidine kinase	ORF36	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
1295	Fatty acid synthase	FASN	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
6151	Monocarboxylate transporter 10	SLC16A10	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6859	Protein S100-A4	S100A4	0.0012
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
5682	Ribonuclease pancreatic	RNASE1	0.0011
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
2298	Cytochrome P450-cam	camC	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4984	Neuroglobin	NGB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
5000	HemO	hemO	0.0008
4910	Cytoglobin	CYGB	0.0008
4909	CooA protein	cooA	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4972	P450cin	cinA	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
3093	Catalase HPII	katE	0.0008
4952	Catalase/peroxidase	katA	0.0008
1867	Major prion protein	PRNP	0.0008
1507	Cytochrome c	CYCS	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
4920	Peroxidase/catalase	katG	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
2802	Endoglucanase G	celCCG	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB08896 - Regorafenib

Targets

Enzymes

Transporters

Predictions