DT-Web: DB00762

Identification

Name

Irinotecan

Accession Number

DB00762 (APRD00579)

Type

small molecule

Description

Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

586.678

Groups

approved

Monoisotopic Weight

586.279134968

Pharmacology

Indication

For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Irinotecan is currently under investigation for the treatment of metastatic or recurrent cervical cancer.

Mechanism of action

Irinotecan inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex. The formation of this ternary complex interferes with the moving replication fork, which induces replication arrest and lethal double-stranded breaks in DNA. As a result, DNA damage is not efficiently repaired and apoptosis (programmed cell death) occurs.

Absorption

The maximum plasma concentration (Cmax) when a dose of 125 mg/m^2 is given to patients with solid tumours is 1660 ng/mL. The AUC (0-24) is 10,200 ng?h/mL. The Cmax when a dose of 340 mg/m^2 is given to patients with solid tumours is 3392 ng/mL. The AUC (0-24) is 20,604 ng?h/mL.

Protein binding

30%-68% protein bound, mainly to albumin.

Biotransformation

Hepatic. The metabolic conversion of irinotecan to the active metabolite SN-38 is mediated by carboxylesterase enzymes and primarily occurs in the liver. SN-38 is subsequently conjugated predominantly by the enzyme UDP-glucuronosyl transferase 1A1 (UGT1A1) to form a glucuronide metabolite.

Route of elimination

The cumulative biliary and urinary excretion of irinotecan and its metabolites (SN-38 and SN-38 glucuronide) over a period of 48 hours following administration of irinotecan in two patients ranged from approximately 25% (100 mg/m2) to 50% (300 mg/m2).

Toxicity

Gastrointestinal complications, such as nausea, vomiting, abdominal cramping, diarrhea, and infection.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Aprepitant	Aprepitant may change levels of the chemotherapy agent, irinotecan.
Atazanavir	Increases levels/effect of irinotecan
Fosphenytoin	The hydantoin decreases the effect of irinotecan
Ketoconazole	Ketoconazole increases the effect and toxicity of irinotecan
Pazopanib	Irinotecan is an uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) substrate and serum concentrations may increase if administered concurrently with pazopanib, an UGT1A1 inhibitor.
Phenytoin	The hydantoin decreases the effect of irinotecan
Regorafenib	Regorafenib may increase levels of irinotecan, a UGT1A1 substrate.
Telithromycin	Telithromycin may reduce clearance of Irinotecan. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Irinotecan if Telithromycin is initiated, discontinued or dose changed.
Thiotepa	Thiotepa, a strong CYP2B6 inhibitor, may decrease the metabolism and clearance of Irinotecan, a CYP2B6 substrate. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Irinotecan if Thiotepa is initiated, discontinued or dose changed.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of irinotecan by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of irinotecan if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Not Available

DNA topoisomerase 1
Name	DNA topoisomerase 1
Gene Name	TOP1
Pharmacological action	yes
Actions	inhibitor
References	Yoshikawa M, Ikegami Y, Hayasaka S, Ishii K, Ito A, Sano K, Suzuki T, Togawa T, Yoshida H, Soda H, Oka M, Kohno S, Sawada S, Ishikawa T, Tanabe S: Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells. Int J Cancer. 2004 Jul 20;110(6):921-7. - Pubmed Yoshikawa M, Ikegami Y, Sano K, Yoshida H, Mitomo H, Sawada S, Ishikawa T: Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid. J Exp Ther Oncol. 2004 Apr;4(1):25-35. - Pubmed Yang X, Hu Z, Chan SY, Chan E, Goh BC, Duan W, Zhou S: Novel agents that potentially inhibit irinotecan-induced diarrhea. Curr Med Chem. 2005;12(11):1343-58. - Pubmed Nakagawa H, Saito H, Ikegami Y, Aida-Hyugaji S, Sawada S, Ishikawa T: Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer. Cancer Lett. 2006 Mar 8;234(1):81-9. Epub 2005 Nov 23. - Pubmed Ishikawa T, Ikegami Y, Sano K, Nakagawa H, Sawada S: Transport mechanism-based drug molecular design: novel camptothecin analogues to circumvent ABCG2-associated drug resistance of human tumor cells. Curr Pharm Des. 2006;12(3):313-25. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Ramesh M, Ahlawat P, Srinivas NR: Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23. - Pubmed Chabot GG: Clinical pharmacokinetics of irinotecan. Clin Pharmacokinet. 1997 Oct;33(4):245-59. - Pubmed
DTHybrid score	1.1773
DNA topoisomerase I, mitochondrial
Name	DNA topoisomerase I, mitochondrial
Gene Name	TOP1MT
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Yoshikawa M, Ikegami Y, Hayasaka S, Ishii K, Ito A, Sano K, Suzuki T, Togawa T, Yoshida H, Soda H, Oka M, Kohno S, Sawada S, Ishikawa T, Tanabe S: Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells. Int J Cancer. 2004 Jul 20;110(6):921-7. - Pubmed Yoshikawa M, Ikegami Y, Sano K, Yoshida H, Mitomo H, Sawada S, Ishikawa T: Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid. J Exp Ther Oncol. 2004 Apr;4(1):25-35. - Pubmed Yang X, Hu Z, Chan SY, Chan E, Goh BC, Duan W, Zhou S: Novel agents that potentially inhibit irinotecan-induced diarrhea. Curr Med Chem. 2005;12(11):1343-58. - Pubmed Nakagawa H, Saito H, Ikegami Y, Aida-Hyugaji S, Sawada S, Ishikawa T: Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer. Cancer Lett. 2006 Mar 8;234(1):81-9. Epub 2005 Nov 23. - Pubmed Ishikawa T, Ikegami Y, Sano K, Nakagawa H, Sawada S: Transport mechanism-based drug molecular design: novel camptothecin analogues to circumvent ABCG2-associated drug resistance of human tumor cells. Curr Pharm Des. 2006;12(3):313-25. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Ramesh M, Ahlawat P, Srinivas NR: Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23. - Pubmed Chabot GG: Clinical pharmacokinetics of irinotecan. Clin Pharmacokinet. 1997 Oct;33(4):245-59. - Pubmed
DTHybrid score	0.3408

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Ramesh M, Ahlawat P, Srinivas NR: Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Kuhn JG: Pharmacology of irinotecan. Oncology (Williston Park). 1998 Aug;12(8 Suppl 6):39-42. - Pubmed
DTHybrid score	0.8969
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5263
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3765
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4012
UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	substrate
References	- Kuhn JG: Pharmacology of irinotecan. Oncology (Williston Park). 1998 Aug;12(8 Suppl 6):39-42. - Pubmed
DTHybrid score	0.3002
UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Actions	substrate
References	Chabot GG: Clinical pharmacokinetics of irinotecan. Clin Pharmacokinet. 1997 Oct;33(4):245-59. - Pubmed
DTHybrid score	0.3266
Liver carboxylesterase 1
Name	Liver carboxylesterase 1
Gene Name	CES1
Actions	substrate
References	Chabot GG: Clinical pharmacokinetics of irinotecan. Clin Pharmacokinet. 1997 Oct;33(4):245-59. - Pubmed Ramesh M, Ahlawat P, Srinivas NR: Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23. - Pubmed Kuhn JG: Pharmacology of irinotecan. Oncology (Williston Park). 1998 Aug;12(8 Suppl 6):39-42. - Pubmed
DTHybrid score	0.6006
Cocaine esterase
Name	Cocaine esterase
Gene Name	Not Available
Actions	substrate
References	Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF: Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11. - Pubmed
DTHybrid score	Not Available
Cholinesterase
Name	Cholinesterase
Gene Name	BCHE
Actions	substrate
References	https://www.pharmgkb.org/pathway/PA2029 -
DTHybrid score	0.6219

Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	inhibitor
References	Shnitsar V, Eckardt R, Gupta S, Grottker J, Muller GA, Koepsell H, Burckhardt G, Hagos Y: Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine. Cancer Res. 2009 Feb 15;69(4):1494-501. Epub 2009 Feb 3. - Pubmed
DTHybrid score	0.205
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Nozawa T, Minami H, Sugiura S, Tsuji A, Tamai I: Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms. Drug Metab Dispos. 2005 Mar;33(3):434-9. Epub 2004 Dec 17. - Pubmed
DTHybrid score	0.3505
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	substrate
References	Chen ZS, Furukawa T, Sumizawa T, Ono K, Ueda K, Seto K, Akiyama SI: ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8. - Pubmed
DTHybrid score	0.3217
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M: Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol. 2003 Jan;63(1):65-72. - Pubmed Maliepaard M, van Gastelen MA, Tohgo A, Hausheer FH, van Waardenburg RC, de Jong LA, Pluim D, Beijnen JH, Schellens JH: Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918. Clin Cancer Res. 2001 Apr;7(4):935-41. - Pubmed
DTHybrid score	0.5016
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Kroetz DL: Role for drug transporters beyond tumor resistance: hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity. J Clin Oncol. 2006 Sep 10;24(26):4225-7. Epub 2006 Aug 8. - Pubmed Han JY, Lim HS, Park YH, Lee SY, Lee JS: Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer. Lung Cancer. 2009 Jan;63(1):115-20. doi: 10.1016/j.lungcan.2007.12.003. Epub 2008 Jan 24. - Pubmed
DTHybrid score	0.791
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Kroetz DL: Role for drug transporters beyond tumor resistance: hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity. J Clin Oncol. 2006 Sep 10;24(26):4225-7. Epub 2006 Aug 8. - Pubmed Han JY, Lim HS, Park YH, Lee SY, Lee JS: Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer. Lung Cancer. 2009 Jan;63(1):115-20. doi: 10.1016/j.lungcan.2007.12.003. Epub 2008 Jan 24. - Pubmed
DTHybrid score	0.3667

Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions
References	Not Available
DTHybrid score	0.205
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions
References	Not Available
DTHybrid score	0.3505
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions
References	Not Available
DTHybrid score	0.3217
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions
References	Not Available
DTHybrid score	0.5016
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.791
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.3667

Id	Partner name	Gene Name	Score
3552	DNA topoisomerase 1	topA	1.1773
4757	Cytochrome P450 2C9	CYP2C9	0.4006
4119	Cytochrome P450 2D6	CYP2D6	0.357
6016	Cytochrome P450 2C19	CYP2C19	0.3348
4924	Cytochrome P450 2C8	CYP2C8	0.3306
4200	Cytochrome P450 1A2	CYP1A2	0.3193
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1687
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1569
6013	Cytochrome P450 2E1	CYP2E1	0.1528
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1505
6024	Cytochrome P450 1A1	CYP1A1	0.1456
20	Prostaglandin G/H synthase 1	PTGS1	0.1393
6145	Solute carrier family 22 member 1	SLC22A1	0.1373
1729	Solute carrier family 22 member 6	SLC22A6	0.1354
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1171
6144	Solute carrier family 22 member 2	SLC22A2	0.1156
776	Bile salt export pump	ABCB11	0.1118
5718	Cytochrome P450 2A6	CYP2A6	0.1112
2164	Multidrug resistance-associated protein 4	ABCC4	0.1111
4180	DNA-(apurinic or apyrimidinic site) lyase	APEX1	0.1088
6142	Solute carrier family 22 member 8	SLC22A8	0.1072
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1067
817	DNA topoisomerase 2-alpha	TOP2A	0.1049
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.1037
474	Acetylcholinesterase	ACHE	0.1026
290	Prostaglandin G/H synthase 2	PTGS2	0.097
118	Organic cation/carnitine transporter 2	SLC22A5	0.095
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0823
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0823
1898	Cytochrome P450 1B1	CYP1B1	0.0809
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0782
6106	Cytochrome P450 2C18	CYP2C18	0.0684
6143	Solute carrier family 22 member 7	SLC22A7	0.067
6148	Multidrug resistance-associated protein 7	ABCC10	0.0642
833	Organic cation/carnitine transporter 1	SLC22A4	0.0611
847	Mu-type opioid receptor	OPRM1	0.0605
3811	Cytochrome P450 19A1	CYP19A1	0.0591
1024	Solute carrier family 22 member 11	SLC22A11	0.0569
556	Alpha-1A adrenergic receptor	ADRA1A	0.0567
6137	Multidrug resistance-associated protein 6	ABCC6	0.0564
731	HIV-1 protease	HIV-1 protease	0.0558
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0557
871	Glucocorticoid receptor	NR3C1	0.0551
766	Beta-2 adrenergic receptor	ADRB2	0.0551
6141	Sodium/bile acid cotransporter	SLC10A1	0.0542
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0539
492	Histamine H1 receptor	HRH1	0.0538
824	Sodium-dependent serotonin transporter	SLC6A4	0.0538
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0534
136	Estrogen receptor	ESR1	0.0532
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0511
831	D(2) dopamine receptor	DRD2	0.0506
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0501
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0493
467	Delta-type opioid receptor	OPRD1	0.0484
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0483
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0474
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0473
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0465
696	Kappa-type opioid receptor	OPRK1	0.0463
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0439
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0438
3810	Catechol O-methyltransferase	COMT	0.0435
504	Mast/stem cell growth factor receptor	KIT	0.0434
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0433
502	5-hydroxytryptamine 2A receptor	HTR2A	0.043
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0428
70	Type-1 angiotensin II receptor	AGTR1	0.0428
26	Vascular endothelial growth factor receptor 3	FLT4	0.0427
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0417
6031	Cytochrome P450 3A43	CYP3A43	0.0411
32	Vascular endothelial growth factor receptor 1	FLT1	0.0408
318	Alpha-2A adrenergic receptor	ADRA2A	0.0395
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0394
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0385
614	Progesterone receptor	PGR	0.0385
713	Sodium-dependent dopamine transporter	SLC6A3	0.0382
6136	Multidrug resistance-associated protein 5	ABCC5	0.0381
844	Epidermal growth factor receptor	EGFR	0.0378
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0372
738	Monocarboxylate transporter 1	SLC16A1	0.0372
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0372
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0367
468	Cytochrome P450 4A11	CYP4A11	0.0366
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0365
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.0365
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0359
407	Vascular endothelial growth factor receptor 2	KDR	0.0359
6606	Platelet-activating factor acetylhydrolase IB subunit gamma	PAFAH1B3	0.0348
275	Arachidonate 5-lipoxygenase	ALOX5	0.0348
4175	Platelet-activating factor acetylhydrolase	PLA2G7	0.0348
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0346
29	Tubulin beta-1 chain	TUBB1	0.0342
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0342
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0341
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0337
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0332
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0332
146	Androgen receptor	AR	0.033
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0325
161	Tubulin beta chain	TUBB	0.0318
312	Tubulin beta chain	TUB2	0.0318
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0317
244	Angiotensin-converting enzyme	ACE	0.031
632	Alpha-1B adrenergic receptor	ADRA1B	0.031
23	D(1A) dopamine receptor	DRD1	0.031
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0309
638	D(3) dopamine receptor	DRD3	0.0305
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0301
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0299
378	Alpha-2C adrenergic receptor	ADRA2C	0.0299
756	Sex hormone-binding globulin	SHBG	0.0298
465	Calmodulin	CALM1	0.0296
891	Dihydropteroate synthase	folP	0.0294
5359	Dihydropteroate synthase	folP	0.0294
7175	Dihydropteroate synthase	sulI	0.0294
232	Corticosteroid-binding globulin	SERPINA6	0.0292
737	Mineralocorticoid receptor	NR3C2	0.028
477	DNA topoisomerase 4 subunit A	parC	0.028
886	DNA topoisomerase 4 subunit A	parC	0.028
6226	DNA topoisomerase 4 subunit A	parC	0.028
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0278
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0277
404	DNA gyrase subunit A	gyrA	0.0275
6224	DNA gyrase subunit A	gyrA	0.0275
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0272
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0272
6102	Arylamine N-acetyltransferase 2	NAT2	0.027
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0269
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0268
6026	Alcohol dehydrogenase 6	ADH6	0.0266
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0262
1757	Myeloperoxidase	MPO	0.026
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.026
3947	Xanthine dehydrogenase/oxidase	XDH	0.0253
260	Cytochrome P450 51	ERG11	0.0249
761	Cytochrome P450 51	ERG11	0.0249
3163	Cytochrome P450 51	cyp51	0.0249
6085	Fatty acid-binding protein, intestinal	FABP2	0.0249
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0248
4120	NADPH--cytochrome P450 reductase	POR	0.0248
869	Estrogen receptor beta	ESR2	0.0247
629	Alpha-2B adrenergic receptor	ADRA2B	0.0247
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0245
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0244
2539	Tubulin alpha-1 chain	TUBA4A	0.0243
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.024
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0238
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0237
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0236
124	Histamine H2 receptor	HRH2	0.0235
122	P2Y purinoceptor 12	P2RY12	0.0235
131	Synaptic vesicular amine transporter	SLC18A2	0.0234
3941	Amine oxidase [flavin-containing] A	MAOA	0.0234
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0234
789	Alpha-1D adrenergic receptor	ADRA1D	0.0228
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0228
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0227
6182	Cytochrome P450 2J2	CYP2J2	0.0223
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0223
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0221
908	Glutathione S-transferase theta-1	GSTT1	0.022
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0217
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0214
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0213
2433	Capsid protein P40	UL80	0.0213
3569	Capsid protein P40	BVRF2	0.0213
33	Cystine/glutamate transporter	SLC7A11	0.0212
24	Thymidylate synthase	TMP1	0.0212
359	Thymidylate synthase	TYMS	0.0212
2626	Thymidylate synthase	thyA	0.0212
2729	Thymidylate synthase	thyA	0.0212
5352	Thymidylate synthase	THYA	0.0212
273	Apoptosis regulator Bcl-2	BCL2	0.0211
904	Glutathione S-transferase P	GSTP1	0.0211
723	Cytosolic phospholipase A2	PLA2G4A	0.0208
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0207
3587	Gastrotropin	FABP6	0.0206
117	Sterol O-acyltransferase 1	SOAT1	0.0206
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0204
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0204
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0203
6220	Aryl hydrocarbon receptor	AHR	0.0202
5880	Thrombopoietin receptor	MPL	0.0201
380	Cytochrome P450 17A1	CYP17A1	0.0198
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0198
193	Beta-1 adrenergic receptor	ADRB1	0.0198
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0197
373	Transthyretin	TTR	0.0197
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0195
5626	Nucleoside diphosphate kinase B	NME2	0.0195
952	Dipeptidyl peptidase 4	DPP4	0.0192
2049	Gastrin/cholecystokinin type B receptor	CCKBR	0.0191
165	FL cytokine receptor	FLT3	0.0189
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0189
1192	Sulfotransferase 1A1	SULT1A1	0.0189
3076	Antigen 85-C	fbpC	0.0187
5787	Angiopoietin-1 receptor	TEK	0.0185
811	Translocator protein	TSPO	0.0183
4773	Deoxycytidine kinase	DCK	0.0181
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0181
885	5-hydroxytryptamine 1B receptor	HTR1B	0.018
2178	Metabotropic glutamate receptor 5	GRM5	0.018
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.018
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.018
1852	Microtubule-associated protein 2	MAP2	0.0178
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0176
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0175
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0174
54	Prothrombin	F2	0.0171
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0167
705	Glutamate receptor 1	GRIA1	0.0167
1656	CYP2B protein	CYP2B	0.0167
5923	Microtubule-associated protein tau	MAPT	0.0165
5924	Microtubule-associated protein 4	MAP4	0.0165
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0163
3866	Serum amyloid A protein	SAA1	0.0163
1200	AMBP protein	AMBP	0.0163
1932	Apolipoprotein E	APOE	0.0163
319	Opioid receptor, sigma 1	OPRS1	0.0162
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0161
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0161
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0161
1050	Bile salt sulfotransferase	SULT2A1	0.0161
6138	Multidrug resistance protein 3	ABCB4	0.016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0159
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0158
5294	Nucleoside diphosphate kinase A	NME1	0.0157
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0157
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0156
818	50S ribosomal protein L10	rplJ	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0153
3809	Estrogen-related receptor gamma	ESRRG	0.0153
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0153
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0152
6043	Putative G-protein coupled receptor 44	GPR44	0.0152
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0152
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0151
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0149
768	FK506-binding protein 1A	FKBP1A	0.0149
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0148
3939	Amine oxidase [flavin-containing] B	MAOB	0.0148
2796	Parathion hydrolase	opd	0.0147
6539	Parathion hydrolase	opd	0.0147
758	Thyroid hormone receptor alpha	THRA	0.0147
4192	DNA topoisomerase 2-beta	TOP2B	0.0145
6167	Organic solute transporter subunit beta	OSTB	0.0145
6166	Organic solute transporter subunit alpha	OSTA	0.0144
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0144
6163	Copper-transporting ATPase 2	ATP7B	0.0143
6165	Copper-transporting ATPase 1	ATP7A	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
1760	Aminopeptidase N	ANPEP	0.0142
6843	Aminopeptidase N	pepN	0.0142
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0142
6146	High affinity copper uptake protein 1	SLC31A1	0.0141
3454	Esterase	estA	0.0141
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0139
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0138
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0138
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0138
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0138
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0137
896	Glutathione S-transferase Mu 1	GSTM1	0.0136
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0134
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0134
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0133
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0133
489	Monocarboxylate transporter 2	SLC16A7	0.0132
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0132
461	Glycine receptor subunit alpha-3	GLRA3	0.0132
346	Thyroid hormone receptor beta-1	THRB	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
6020	Aldehyde oxidase	AOX1	0.0131
3307	Acriflavine resistance protein B	acrB	0.013
4237	50S ribosomal protein L22	rplV	0.013
1618	High affinity nerve growth factor receptor	NTRK1	0.0129
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0129
1630	Integrin beta-2	ITGB2	0.0128
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0127
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0127
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
1650	Heme carrier protein 1	SLC46A1	0.0126
183	Vascular endothelial growth factor A	VEGFA	0.0125
1517	Beta-3 adrenergic receptor	ADRB3	0.0125
6168	Solute carrier family 22 member 16	SLC22A16	0.0125
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0124
2929	(S)-2-haloacid dehalogenase	dhlB	0.0124
2995	(S)-2-haloacid dehalogenase	Not Available	0.0124
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0123
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0123
3856	Fibroblast growth factor receptor 3	FGFR3	0.0123
482	Glycine receptor subunit alpha-1	GLRA1	0.0123
6500	Phospholipase A2	PLA2G1B	0.0123
1636	Trace amine-associated receptor 1	TAAR1	0.0122
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0122
3639	Thymidine phosphorylase	deoA	0.0121
3936	Thymidine phosphorylase	TYMP	0.0121
3611	Cytidine deaminase	cdd	0.0121
3707	Cytidine deaminase	cdd	0.0121
4211	Cytidine deaminase	CDA	0.0121
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0121
432	D(4) dopamine receptor	DRD4	0.0121
4238	50S ribosomal protein L4	rplD	0.012
5578	50S ribosomal protein L4	rplD	0.012
6173	50S ribosomal protein L4	rplD	0.012
6219	50S ribosomal protein L4	rplD	0.012
1141	Sialidase-1	NEU1	0.012
64	Neuraminidase	NA	0.012
641	Neuraminidase	NA	0.012
2676	Neuraminidase	NA	0.012
3026	Neuraminidase	NA	0.012
3519	Neuraminidase	NA	0.012
6007	Neuraminidase	NA	0.012
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0117
594	Thyroxine-binding globulin	SERPINA7	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0115
6042	Prostaglandin reductase 2	PTGR2	0.0114
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0114
6149	Solute carrier family 22 member 10	SLC22A10	0.0112
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0111
992	Protein tyrosine kinase 2 beta	PTK2B	0.0109
716	5-hydroxytryptamine 7 receptor	HTR7	0.0109
2443	Azurin	azu	0.0108
6014	Cytochrome P450 2A13	CYP2A13	0.0108
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0108
823	Fibroblast growth factor receptor 2	FGFR2	0.0107
777	Tumor necrosis factor	TNF	0.0106
469	Annexin A1	ANXA1	0.0106
6103	Arylamine N-acetyltransferase 1	NAT1	0.0105
2211	Fatty acid-binding protein, heart	FABP3	0.0105
284	DNA-directed RNA polymerase beta chain	rpoB	0.0104
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0104
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0104
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0104
267	Plasminogen activator inhibitor 1	SERPINE1	0.0104
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0103
936	Ephrin type-A receptor 2	EPHA2	0.0103
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0103
5482	Sialidase-2	NEU2	0.0102
1525	Heparin-binding growth factor 2	FGF2	0.0102
702	UMP-CMP kinase	CMPK1	0.0101
3932	Glutathione S-transferase A2	GSTA2	0.0101
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0101
1313	Lactoylglutathione lyase	GLO1	0.0101
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0101
174	Sigma 1-type opioid receptor	SIGMAR1	0.0101
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.01
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.01
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.01
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0099
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0099
1010	Cytochrome P450 51A1	CYP51A1	0.0098
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0098
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0098
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0098
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0097
2449	Tubulin alpha-3 chain	TUBA1A	0.0097
2808	Chloramphenicol acetyltransferase 3	cat3	0.0097
2021	Thrombomodulin	THBD	0.0097
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0096
6221	Steroid hormone receptor ERR1	ESRRA	0.0096
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0096
427	Substance-P receptor	TACR1	0.0096
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0095
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
1629	Transcription factor AP-1	JUN	0.0095
566	Serotransferrin	TF	0.0094
459	Retinoic acid receptor RXR-alpha	RXRA	0.0094
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0094
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0094
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0094
6044	Serum paraoxonase/lactonase 3	PON3	0.0093
5798	Mitogen-activated protein kinase 11	MAPK11	0.0093
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0092
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0092
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0092
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0091
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0091
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0091
4122	Histone deacetylase 2	HDAC2	0.009
6432	Transporter	snf	0.009
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0088
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0088
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0087
572	Integrin alpha-L	ITGAL	0.0087
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0085
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0084
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0084
6070	Nischarin	NISCH	0.0083
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0082
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0082
551	Carnitine O-acetyltransferase	CRAT	0.0082
850	Vasopressin V1b receptor	AVPR1B	0.0081
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0081
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0081
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0081
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
84	Nuclear receptor 0B1	NR0B1	0.0079
4203	Histamine N-methyltransferase	HNMT	0.0079
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0078
163	D(1B) dopamine receptor	DRD5	0.0078
85	Growth hormone receptor	GHR	0.0077
293	Gamma-glutamyl hydrolase	GGH	0.0076
1178	Adenosine A2a receptor	ADORA2A	0.0075
2472	Voltage-gated potassium channel	kcsA	0.0075
6366	Voltage-gated potassium channel	kcsA	0.0075
6501	Fatty acid-binding protein, liver	FABP1	0.0075
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0075
239	Coagulation factor X	F10	0.0075
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
2391	Ferrochelatase	hemH	0.0073
6502	Ferrochelatase	DKFZp686P18130	0.0073
1591	Ferrochelatase, mitochondrial	FECH	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0072
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0072
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
68	Cannabinoid receptor 1	CNR1	0.0071
5414	Fiber protein	L5	0.0071
5418	Fiber protein	L5	0.0071
1756	E-selectin	SELE	0.0071
2599	Tyrosine-protein kinase HCK	HCK	0.0071
3937	Fatty-acid amide hydrolase	FAAH	0.007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.007
6837	Serine/threonine-protein kinase 17B	STK17B	0.007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.007
7	Nitric oxide synthase, inducible	NOS2	0.007
6210	Tubulin delta chain	TUBD1	0.0069
6211	Tubulin epsilon chain	TUBE1	0.0069
6212	Tubulin gamma-1 chain	TUBG1	0.0069
94	5-hydroxytryptamine 4 receptor	HTR4	0.0068
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0068
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0067
1792	Tissue-type plasminogen activator	PLAT	0.0067
199	Monocarboxylate transporter 8	SLC16A2	0.0067
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0066
36	Insulin receptor	INSR	0.0066
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0065
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0064
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0064
164	Histamine H4 receptor	HRH4	0.0064
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0064
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0064
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0064
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0064
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0064
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0064
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0064
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0064
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0064
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0063
6559	Cytochrome c oxidase subunit 2	ctaC	0.0063
6669	Cytochrome c oxidase subunit 2	ctaC	0.0063
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0063
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0063
6558	Cytochrome c oxidase subunit 1	ctaD	0.0063
563	Thyroid peroxidase	TPO	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
1275	Estrogen sulfotransferase	SULT1E1	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
2207	Rhodopsin	RHO	0.0063
3270	Elongation factor G	fusA	0.0062
1341	Histamine H3 receptor	HRH3	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
760	Fibroblast growth factor 1	FGF1	0.0062
3629	Endo-N-acetylneuraminidase	Not Available	0.0062
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0062
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0062
5416	Coat protein VP1	Not Available	0.0061
1130	Lithostathine 1 alpha	REG1A	0.0061
5818	Folate receptor alpha	FOLR1	0.0061
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0061
814	Ryanodine receptor 1	RYR1	0.0061
153	Dopamine beta-hydroxylase	DBH	0.0061
558	Solute carrier family 12 member 1	SLC12A1	0.0061
5126	Arginase	rocF	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
208	DNA-directed RNA polymerase beta' chain	rpoC	0.006
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
780	Retinoic acid receptor RXR-gamma	RXRG	0.006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0059
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0059
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0059
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
2540	Choloylglycine hydrolase	cbh	0.0058
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0058
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0058
3426	Glutamine synthetase	glnA	0.0057
3987	Glutamine synthetase	GLUL	0.0057
2324	Botulinum neurotoxin type B	botB	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
3547	Enterotoxin type B	entB	0.0057
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0056
2058	P-selectin	SELP	0.0056
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0056
365	Dihydrofolate reductase	DHFR	0.0056
2381	Dihydrofolate reductase	DFR1	0.0056
2833	Dihydrofolate reductase	Not Available	0.0056
2931	Dihydrofolate reductase	folA	0.0056
3544	Dihydrofolate reductase	folA	0.0056
3682	Dihydrofolate reductase	folA	0.0056
6642	Dihydrofolate reductase	folA	0.0056
6756	Dihydrofolate reductase	dfrA	0.0056
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0055
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0055
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0055
88	Retinoic acid receptor RXR-beta	RXRB	0.0055
921	Glutamate receptor 2	GRIA2	0.0053
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0053
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0053
144	Hemoglobin subunit alpha	HBA1	0.0052
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0052
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0052
751	Potassium channel subfamily K member 6	KCNK6	0.0052
517	Alcohol dehydrogenase 1C	ADH1C	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
5300	Antigen peptide transporter 1	TAP1	0.0051
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0051
1714	Mitogen-activated protein kinase 3	MAPK3	0.0051
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0051
3927	Choline transporter-like protein 3	SLC44A3	0.0051
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0051
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0051
769	High-affinity choline transporter 1	SLC5A7	0.0051
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0051
861	Choline kinase alpha	CHKA	0.0051
1686	Choline transporter-like protein 1	SLC44A1	0.0051
3926	Choline transporter-like protein 2	SLC44A2	0.0051
700	Choline dehydrogenase, mitochondrial	CHDH	0.0051
3925	Choline transporter-like protein 4	SLC44A4	0.0051
576	Choline O-acetyltransferase	CHAT	0.0051
3922	Phospholipase D2	PLD2	0.0051
3924	Phospholipase D1	PLD1	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.005
595	Fibrinogen alpha chain	FGA	0.005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.005
6228	Nuclear receptor coactivator 1	NCOA1	0.005
5934	Cytochrome P450 26A1	CYP26A1	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
4787	Envelope glycoprotein gp160	env	0.0049
4820	Envelope glycoprotein gp160	env	0.0049
5727	Envelope glycoprotein gp160	env	0.0049
2570	Tetanus toxin	tetX	0.0049
1483	Membrane copper amine oxidase	AOC3	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
357	Carbonic anhydrase 2	CA2	0.0048
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0048
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0048
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0048
172	Potassium channel subfamily K member 1	KCNK1	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0047
4692	A/G-specific adenine glycosylase	mutY	0.0047
295	Carbonic anhydrase 1	CA1	0.0047
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0047
1864	RET proto-oncogene	RET	0.0047
624	Guanidinoacetate N-methyltransferase	GAMT	0.0047
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0047
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0047
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0047
76	Nitric-oxide synthase, brain	NOS1	0.0047
6241	Nuclear receptor coactivator 2	NCOA2	0.0047
6824	Tyrosine-protein kinase Lyn	LYN	0.0047
683	Potassium transporter	GK0582	0.0047
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0046
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0046
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0046
856	Vitamin D3 receptor	VDR	0.0046
4784	Beta-mannosidase	manB	0.0046
6695	Beta-mannosidase	BT_0458	0.0046
6151	Monocarboxylate transporter 10	SLC16A10	0.0046
2232	Interleukin-5	IL5	0.0045
1593	Mucin-2	MUC2	0.0045
1039	Histone deacetylase 9	HDAC9	0.0045
2300	Lysozyme	E	0.0045
3633	Lysozyme	R	0.0045
5597	Lysozyme	17	0.0045
162	Retinoic acid receptor gamma-1	RARG	0.0045
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0045
6218	Pannexin-1	PANX1	0.0044
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0044
106	Cannabinoid receptor 2	CNR2	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0043
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0043
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0042
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0042
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
1196	Complement decay-accelerating factor	CD55	0.0042
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0042
2723	Cholera enterotoxin subunit B	ctxB	0.0042
484	Tyrosine-protein kinase ABL2	ABL2	0.0042
1569	G1/S-specific cyclin-D1	CCND1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3679	MTA/SAH nucleosidase	mtnN	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
775	Acetyl-CoA carboxylase 2	ACACB	0.004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
291	Nitric-oxide synthase, endothelial	NOS3	0.0039
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0039
4217	Telomerase reverse transcriptase	TERT	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
128	Adenine phosphoribosyltransferase	APRT	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
6677	Myelin P2 protein	PMP2	0.0038
1992	Vitamin D-binding protein	GC	0.0038
1123	Eosinophil cationic protein	RNASE3	0.0038
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0038
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0037
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0037
2216	Fibroblast growth factor receptor 4	FGFR4	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0036
2112	Toll-like receptor 9	TLR9	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
16	Adenosine A1 receptor	ADORA1	0.0036
4210	Toll-like receptor 4	TLR4	0.0035
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0035
6131	Carbonic anhydrase 14	CA14	0.0035
719	Retinoic acid receptor responder protein 1	RARRES1	0.0035
770	Retinoic acid-induced protein 3	GPRC5A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
976	Platelet glycoprotein IX	GP9	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
2297	Genome polyprotein	Not Available	0.0034
2322	Genome polyprotein	Not Available	0.0034
2694	Genome polyprotein	Not Available	0.0034
2719	Genome polyprotein	Not Available	0.0034
2860	Genome polyprotein	Not Available	0.0034
2928	Genome polyprotein	Not Available	0.0034
3160	Genome polyprotein	Not Available	0.0034
3260	Genome polyprotein	Not Available	0.0034
4783	Genome polyprotein	Not Available	0.0034
5726	Genome polyprotein	Not Available	0.0034
5779	Genome polyprotein	Not Available	0.0034
5867	Genome polyprotein	Not Available	0.0034
6253	Genome polyprotein	Not Available	0.0034
6301	Genome polyprotein	Not Available	0.0034
6380	Genome polyprotein	Not Available	0.0034
6381	Genome polyprotein	Not Available	0.0034
6437	Genome polyprotein	Not Available	0.0034
6520	Genome polyprotein	Not Available	0.0034
6521	Genome polyprotein	Not Available	0.0034
6652	Genome polyprotein	Not Available	0.0034
6734	Genome polyprotein	Not Available	0.0034
6735	Genome polyprotein	Not Available	0.0034
6736	Genome polyprotein	Not Available	0.0034
6737	Genome polyprotein	Not Available	0.0034
6738	Genome polyprotein	Not Available	0.0034
6739	Genome polyprotein	Not Available	0.0034
6744	Genome polyprotein	Not Available	0.0034
6748	Genome polyprotein	Not Available	0.0034
6894	Genome polyprotein	Not Available	0.0034
6898	Genome polyprotein	Not Available	0.0034
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0034
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0033
5682	Ribonuclease pancreatic	RNASE1	0.0033
3601	Dihydropteroate synthase 1	folP1	0.0033
3807	Dihydropteroate synthase 1	folP1	0.0033
3808	Dihydropteroate synthase 2	folP2	0.0033
2417	Chloramphenicol acetyltransferase	cat	0.0033
3278	Chloramphenicol acetyltransferase	cat	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
2810	Dr hemagglutinin structural subunit	draA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0032
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0032
828	Phenylalanine-4-hydroxylase	PAH	0.0032
3109	Phenylalanine-4-hydroxylase	phhA	0.0032
1867	Major prion protein	PRNP	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
1291	cAMP response element-binding protein	CREB1	0.0032
3086	Plasmepsin-2	Not Available	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
2320	Thymidine kinase, cytosolic	TK1	0.0031
1262	Corticotropin-lipotropin	POMC	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
569	Retinal dehydrogenase 2	ALDH1A2	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
4785	Ig gamma-1 chain C region	IGHG1	0.003
3437	Eosinophil lysophospholipase	CLC	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6048	Troponin C, skeletal muscle	TNNC2	0.003
581	Cytochrome P450 2R1	CYP2R1	0.003
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
4878	Glycoprotein hormones alpha chain	CGA	0.0029
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0029
1072	Granzyme B	GZMB	0.0029
4877	Beta-mannanase	man	0.0029
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0029
4850	Beta-2-glycoprotein 1	APOH	0.0029
4889	Ig epsilon chain C region	IGHE	0.0029
4856	CD209 antigen	CD209	0.0029
4869	Major capsid protein	A430L	0.0029
4880	Membrane cofactor protein	CD46	0.0029
4852	Reticulon-4 receptor	RTN4R	0.0029
757	Fusion glycoprotein F0	F	0.0029
4875	Fusion glycoprotein F0	F	0.0029
1354	Beta-glucuronidase	GUSB	0.0029
4189	Alpha-galactosidase A	GLA	0.0029
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0029
442	Envelope glycoprotein	gp41	0.0029
4859	Envelope glycoprotein	env	0.0029
4721	Beta-1,4-mannanase	manA	0.0029
4845	ADAM 33	ADAM33	0.0029
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0029
3352	Structural polyprotein	Not Available	0.0029
3628	Structural polyprotein	Not Available	0.0029
4892	Structural polyprotein	Not Available	0.0029
611	Retinal dehydrogenase 1	ALDH1A1	0.0029
4226	Uridine phosphorylase 2	UPP2	0.0029
65	Matrix metalloproteinase-9	Not Available	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
605	Fumarate reductase flavoprotein subunit	frdA	0.0028
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0028
3673	Fumarate reductase flavoprotein subunit	fccA	0.0028
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0028
6549	Fumarate reductase flavoprotein subunit	frdA	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
4103	Proteasome subunit beta type 2	PSMB2	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4311	tRNA	TRDMT1	0.0027
4325	tRNA	trmD	0.0027
4328	tRNA	trmD	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
4225	Uridine phosphorylase 1	UPP1	0.0027
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
49	Endothelin B receptor	EDNRB	0.0026
3959	Cell division protein kinase 4	CDK4	0.0025
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
229	Retinoic acid receptor beta	RARB	0.0025
793	T-cell surface antigen CD2	CD2	0.0025
4861	Interleukin-6 receptor alpha chain	IL6R	0.0025
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0025
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0025
3837	Cytokine receptor common beta chain	CSF2RB	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
413	Amidophosphoribosyltransferase	PPAT	0.0025
2515	Amidophosphoribosyltransferase	purF	0.0025
3714	Amidophosphoribosyltransferase	purF	0.0025
730	Retinoic acid receptor alpha	RARA	0.0024
4041	Microsomal glutathione S-transferase 2	MGST2	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
3616	Fatty acid-binding protein, epidermal	FABP5	0.0024
5431	Lipid binding protein	Not Available	0.0024
5433	UPF0230 protein TM_1468	TM_1468	0.0024
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6858	Inactive carboxylesterase 4	CES1P1	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
6459	Glycodelin	PAEP	0.0024
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0024
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
4890	Hemagglutinin	HA	0.0023
6566	Hemagglutinin	Not Available	0.0023
1379	Interleukin-12 subunit beta	IL12B	0.0023
1184	Interferon beta	IFNB1	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0021
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
1268	Neuropeptide S receptor	NPSR1	0.002
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.002
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.002
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.002
554	Low-density lipoprotein receptor	LDLR	0.002
283	SEC14-like protein 2	SEC14L2	0.002
852	Heparin cofactor 2	SERPIND1	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1859	Prostatic acid phosphatase	ACPP	0.002
6755	Poliovirus receptor	PVR	0.002
3140	Hemagglutinin-neuraminidase	HN	0.002
3609	Hemagglutinin-neuraminidase	HN	0.002
3444	Cyanovirin-N	Not Available	0.002
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
4031	Glutathione S-transferase A1	GSTA1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0018
6072	Potassium channel subfamily K member 3	KCNK3	0.0018
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
4666	Fucose-binding lectin PA-IIL	lecB	0.0018
2372	Bifunctional tail protein	9	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
444	Alcohol dehydrogenase 1B	ADH1B	0.0017
958	Insulin-like growth factor 1 receptor	IGF1R	0.0017
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0017
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0017
1928	Leukotriene C4 synthase	LTC4S	0.0017
4034	Glutaredoxin-1	GLRX	0.0017
910	Epididymal secretory glutathione peroxidase	GPX5	0.0017
4037	Hypothetical protein	GPX1	0.0017
4297	Hypothetical protein	SP_1951	0.0017
4521	Hypothetical protein	BC_2969	0.0017
4540	Hypothetical protein	TM_1070	0.0017
4555	Hypothetical protein	MT1739	0.0017
4569	Hypothetical protein	mshD	0.0017
4578	Hypothetical protein	PA3270	0.0017
4747	Hypothetical protein	PA3967	0.0017
5177	Hypothetical protein	TM_0096	0.0017
5194	Hypothetical protein	PA1204	0.0017
5240	Hypothetical protein	Rv2991	0.0017
5370	Hypothetical protein	TM_1158	0.0017
5710	Hypothetical protein	Tb927.5.1360	0.0017
4029	Microsomal glutathione S-transferase 3	MGST3	0.0017
4036	Glutathione peroxidase 6	GPX6	0.0017
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0017
4032	Microsomal glutathione S-transferase 1	MGST1	0.0017
903	Glutathione S-transferase A5	GSTA5	0.0017
4040	Glutathione peroxidase 7	GPX7	0.0017
907	Glutathione peroxidase 2	GPX2	0.0017
900	Glutathione S-transferase A4	GSTA4	0.0017
911	Glutathione peroxidase 3	GPX3	0.0017
906	Glutathione peroxidase 1	GPX1	0.0017
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0017
4035	Glutathione S-transferase Mu 5	GSTM5	0.0017
4042	Glutathione transferase omega-2	GSTO2	0.0017
4038	Glutathione peroxidase 4	GPX4	0.0017
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0017
4033	S-formylglutathione hydrolase	ESD	0.0017
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0017
1243	Cathepsin D	CTSD	0.0016
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0016
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0016
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0016
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0016
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0016
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
1439	Lactotransferrin	LTF	0.0016
3814	Complement C1r subcomponent	C1R	0.0016
173	Toll-like receptor 7	TLR7	0.0016
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0016
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0016
898	Glutathione S-transferase A3	GSTA3	0.0016
897	Glutathione S-transferase kappa 1	GSTK1	0.0015
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
251	Alcohol dehydrogenase 1A	ADH1A	0.0015
909	Maleylacetoacetate isomerase	GSTZ1	0.0015
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0015
309	Antithrombin-III	SERPINC1	0.0015
2430	Chondroitinase B	cslB	0.0015
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0015
899	Glutathione S-transferase Mu 3	GSTM3	0.0015
905	Glutathione transferase omega-1	GSTO1	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
6307	Ig gamma-2 chain C region	IGHG2	0.0015
2581	Chondroitinase AC	cslA	0.0015
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0014
1541	Metalloproteinase	mmp20	0.0014
820	Glycine receptor subunit alpha-2	GLRA2	0.0014
6847	Lactase-phlorizin hydrolase	LCT	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0014
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0014
2165	Glutathione S-transferase Mu 2	GSTM2	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
207	Glutathione synthetase	GSS	0.0013
5269	Glutathione synthetase	gshB	0.0013
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
4608	Putative cytochrome P450	SCO1207	0.0013
4963	Putative cytochrome P450	SCO2884	0.0013
6254	Putative cytochrome P450	SCO6998	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
901	Glutathione S-transferase Mu 4	GSTM4	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
822	Aldose reductase	AKR1B1	0.0012
4498	Ornithine cyclodeaminase	PP3533	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
292	Activin receptor type-1	ACVR1	0.0012
1295	Fatty acid synthase	FASN	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
5449	Hypothetical gliding protein	mglB	0.0012
5443	UPF0189 protein ymdB	ymdB	0.0012
5440	UPF0067 protein yebR	yebR	0.0012
4705	Manganese catalase	Not Available	0.0012
5439	33 kDa chaperonin	hslO	0.0012
5446	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	HI_1679	0.0012
2720	Copper-containing nitrite reductase	nirK	0.0012
5448	Ribonuclease Z	rnz	0.0012
3781	Thiol:disulfide interchange protein dsbC precursor	dsbC	0.0012
5447	Lethal(3)malignant brain tumor-like protein	L3MBTL1	0.0012
5454	Internalin-A	inlA	0.0012
3957	Adenosine deaminase	ADA	0.0012
6859	Protein S100-A4	S100A4	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
714	Glutathione reductase, mitochondrial	GSR	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0011
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
5450	Prolyl endopeptidase Pep	pep	0.0011
518	Peroxidase/catalase T	katG	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
3356	Diaminopimelate decarboxylase	lysA	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
597	Dihydropteridine reductase	QDPR	0.001
4771	Dissimilatory copper-containing nitrite reductase	nir	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
3274	Hydroxylamine reductase	hcp	0.001
4804	Hydroxylamine reductase	hcp	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
2714	Chorismate mutase	aroH	0.001
4611	Chorismate mutase	aroG	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.001
3399	Limonene-1,2-epoxide hydrolase	limA	0.001
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
2298	Cytochrome P450-cam	camC	0.0009
5180	L(+)-mandelate dehydrogenase	mdlB	0.0009
577	Argininosuccinate lyase	ASL	0.0009
3500	Putative family 31 glucosidase yicI	yicI	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
1615	Chymase	CMA1	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
3221	Cytochrome c4	cc4	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
4954	Soluble cytochrome b558	Not Available	0.0007
4943	Cytochrome c6	petJ	0.0007
4916	Cyanoglobin	glbN	0.0007
4925	Cytochrome c-type protein SHP	shp	0.0007
4994	Hemoglobin-like protein HbO	glbO	0.0007
4984	Neuroglobin	NGB	0.0007
4947	Bacterial hemoglobin	vhb	0.0007
4915	Cytochrome c-550	psbV	0.0007
4959	Cytochrome c-550	psbV	0.0007
5216	Cytochrome c-550	psbV	0.0007
4975	Cytochrome c-556	RPA3973	0.0007
4981	Iron-starvation protein PigA	pigA	0.0007
5000	HemO	hemO	0.0007
4942	Diheme cytochrome c napB	napB	0.0007
4934	Cytochrome c-551	nirM	0.0007
5218	Cytochrome c-551	nirM	0.0007
4905	Cytochrome c2	Not Available	0.0007
4939	Cytochrome c2	cycA	0.0007
4964	Cytochrome c2	cycA	0.0007
4979	Cytochrome c2	cycA	0.0007
6673	Cytochrome c2	cycA	0.0007
4910	Cytoglobin	CYGB	0.0007
4936	Cytochrome c2 iso-2	Not Available	0.0007
4935	Cytochrome c-554	cycA1	0.0007
4909	CooA protein	cooA	0.0007
4998	Hemoglobin-like protein yjbI	yjbI	0.0007
4961	Hemophore HasA	hasA	0.0007
4907	Cytochrome c-L	moxG	0.0007
6865	Cytochrome c-L	moxG	0.0007
644	Heme oxygenase 2	HMOX2	0.0007
4982	Heme oxygenase 2	pbsA2	0.0007
4971	Nonaheme cytochrome c	hmcA	0.0007
4931	Cytochrome P450 167A1	CYP167A1	0.0007
4904	Cytochrome c family protein	GSU1996	0.0007
4976	Apocytochrome f	petA	0.0007
6407	Apocytochrome f	petA	0.0007
4972	P450cin	cinA	0.0007
4903	Methyl-accepting chemotaxis protein	Tar4	0.0007
4937	Cytochrome oxidase subunit II	rcoxA	0.0007
4960	Putative cytochrome P450-family protein	SCO7417	0.0007
4764	Cytochrome P450 165C4	CYP165C4	0.0007
4989	Cytochrome c551 peroxidase	ccp	0.0007
5222	Cytochrome c551 peroxidase	ccpA	0.0007
4999	Cytochrome P450 165B3	CYP165B3	0.0007
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0007
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0007
4993	Hydroxylamine oxidoreductase	hao1	0.0007
4922	Cytochrome c, putative	SO_4144	0.0007
4952	Catalase/peroxidase	katA	0.0007
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0007
3093	Catalase HPII	katE	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
4920	Peroxidase/catalase	katG	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
4948	Cytochrome c-553	Not Available	0.0005
6753	Apolipoprotein M	APOM	0.0005
4923	Cytochrome c3	DvMF_2499	0.0005
4945	Cytochrome c3	Not Available	0.0005
4949	Cytochrome c3	DVU_3171	0.0005
4968	Cytochrome c3	cytc3	0.0005
4997	Cytochrome c3	SO_2727	0.0005
5219	Cytochrome c3	cyd	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
2119	Cytochrome b5	CYB5A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
4902	Nine-heme cytochrome c	Ddes_2038	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
3189	High-molecular-weight cytochrome c	hmcA	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
4990	PpcA	ppcA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0005
3375	Acidic cytochrome c3	Not Available	0.0005
4988	Sulfite oxidase, mitochondrial	SUOX	0.0005
2915	Sensor protein fixL	fixL	0.0005
4944	Sensor protein fixL	fixL	0.0005
3570	Cytochrome P450 152A1	cypC	0.0005
4813	Heme oxygenase	hmuO	0.0005
5769	Heme oxygenase	Not Available	0.0005
4385	Cytochrome c'	Not Available	0.0005
4967	Cytochrome c'	cycA	0.0005
5038	Cytochrome c'	Not Available	0.0005
5223	Cytochrome c'	cycP	0.0005
4289	Cytochrome P450	TT_P0059	0.0005
6262	Cytochrome P450	staP	0.0005
4992	Cytochrome c peroxidase	Not Available	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
2230	Catalase	CAT	0.0005
3249	Catalase	katA	0.0005
3625	Catalase	katA	0.0005
4539	Catalase	katA	0.0005
4941	Catalase	katB	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
4386	Hemoglobin-like protein HbN	glbN	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3127	Nitrite reductase	nirS	0.0004
3284	Nitrite reductase	nirS	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0004
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
2802	Endoglucanase G	celCCG	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
1507	Cytochrome c	CYCS	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
810	Heme oxygenase 1	HMOX1	0.0003
3391	Heme oxygenase 1	pbsA1	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00762 - Irinotecan

Targets

Enzymes

Transporters

Carriers

Predictions