DT-Web

DB01008 - Busulfan


Identification
Name Busulfan
Accession Number DB01008 (APRD00664)
Type small molecule
Description Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 246.302
Groups approved
Monoisotopic Weight 246.02317956
Pharmacology
Indication For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia (FDA has designated busulfan as an orphan drug for this use). It is also used as a component of pretransplant conditioning regimens in patients undergoing bone marrow transplantation for acute myeloid leukemia and nonmalignant diseases.
Mechanism of action Busulfan is an alkylating agent that contains 2 labile methanesulfonate groups attached to opposite ends of a 4-carbon alkyl chain. Once busulfan is hydrolyzed, the methanesulfonate groups are released and carbonium ions are produced. These carbonium ions alkylate DNA, which results in the interference of DNA replication and RNA transcription, ultimately leading to the disruption of nucleic acid function. Specifically, its mechanism of action through alkylation produces guanine-adenine intrastrand crosslinks. This occurs through an SN2 reaction in which the relatively nucleophilic guanine N7 attacks the carbon adjacent to the mesylate leaving group. This kind of damage cannot be repaired by cellular machinery and thus the cell undergoes apoptosis.
Absorption Completely absorbed from the gastrointestinal tract. Busulfan is a small, highly lipophilic molecule that crosses the blood-brain-barrier. The absolute bioavailability, if a single 2 mg IV bolus injection is given to adult patients, is 80% ? 20%. In children (1.5 - 6 years old), the absolute bioavailability was 68% ? 31%. When a single oral dose is given to patients, the area under the curve (AUC) was 130 ngohr/mL. The peak plasma concentration when given orally is 30 ng/mL (after dose normalization to 2 mg). It takes 0.9 hours to reach peak plasma concentration after dose normalization to 4 mg.
Protein binding 32% bound to plasma proteins and 47% bound to red blood cells.
Biotransformation Busulfan is extensively metabolizes in the hepatic. Busulfan is predominantly metabolized by conjugation with glutathione, both spontaneously and by glutathione S-transferase (GST) catalysis. GSTA1 is the primary GST isoform that facilitates the the metabolism of busulfan. Other GST isoforms that are also involved are GSTM1 and GSTP1. At least 12 metabolites have been identified among which tetrahydrothiophene, tetrahydrothiophene 12-oxide, sulfolane, and 3-hydroxysulfolane were identified. These metabolites do not have cytotoxic activity.
Route of elimination Following administration of 14C- labeled busulfan to humans, approximately 30% of the radioactivity was excreted into the urine over 48 hours; negligible amounts were recovered in feces. Less than 2% of the administered dose is excreted in the urine unchanged within 24 hours. Elimination of busulfan is independent of renal function.
Toxicity Signs of overdose include allergic reaction, unusual bleeding or bruising, sudden weakness or unusual fatigue, persistent cough, congestion, or shortness of breath; flank, stomach or joint pain; pronounced nausea, vomiting, diarrhea, dizziness, confusion, or darkening of the skin, chills, fever, collapse, and loss of consciousness.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Bendamustine Increases toxicity through pharmacodynamic synergism.
Itraconazole Itraconazole reduced busulfan clearance by up to 25% in patients receiving itraconazole compared to those that did not receive it. Concomitant therapy may lead to toxic plasma levels of busulfan.
Metronidazole Metronidazole increases the effect/toxicity of busulfan
Telithromycin Telithromycin may reduce clearance of Busulfan. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Busulfan if Telithromycin is initiated, discontinued or dose changed.
Thioguanine Busulfan increases the hepatoxicity of Thioguanine during long-term concomitant therapy.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of busulfan by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of busulfan if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals.
  • Drink liberally.

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions cross-linking/alkylation
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Morales-Ramirez P, Gonzalez-Beltran F: Different behavior of SCE-eliciting lesions induced by low and high doses of busulfan. Environ Mol Mutagen. 2007 Sep 26;48(8):706-714. - Pubmed
  • Valdez BC, Andersson BS: Interstrand crosslink inducing agents in pretransplant conditioning therapy for hematologic malignancies. Environ Mol Mutagen. 2010 Jul;51(6):659-68. - Pubmed
  • Hall AG, Tilby MJ: Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies. Blood Rev. 1992 Sep;6(3):163-73. - Pubmed
  • Ciurea SO, Andersson BS: Busulfan in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2009 May;15(5):523-36. Epub 2009 Feb 12. - Pubmed
  • McCune JS, Holmberg LA: Busulfan in hematopoietic stem cell transplant setting. Expert Opin Drug Metab Toxicol. 2009 Aug;5(8):957-69. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3194
Glutathione S-transferase A2
Name Glutathione S-transferase A2
Gene Name GSTA2
Actions substrate
References
  • Vassord C, Lapoumeroulie C, Koumaravelou K, Srivastava A, Krishnamoorthy R: Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation. Eur J Haematol. 2008 Apr;80(4):299-302. Epub 2008 Jan 14. - Pubmed
DTHybrid score 0.3705
Glutathione S-transferase A1
Name Glutathione S-transferase A1
Gene Name GSTA1
Actions substrate
References
  • Kusama M, Kubota T, Matsukura Y, Matsuno K, Ogawa S, Kanda Y, Iga T: Influence of glutathione S-transferase A1 polymorphism on the pharmacokinetics of busulfan. Clin Chim Acta. 2006 Jun;368(1-2):93-8. Epub 2006 Jan 31. - Pubmed
  • Elhasid R, Krivoy N, Rowe JM, Sprecher E, Adler L, Elkin H, Efrati E: Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2010 Dec 1;55(6):1172-9. - Pubmed
  • Vassord C, Lapoumeroulie C, Koumaravelou K, Srivastava A, Krishnamoorthy R: Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation. Eur J Haematol. 2008 Apr;80(4):299-302. Epub 2008 Jan 14. - Pubmed
DTHybrid score 0.8067
Glutathione S-transferase Mu 1
Name Glutathione S-transferase Mu 1
Gene Name GSTM1
Actions substrate
References
  • Czerwinski M, Gibbs JP, Slattery JT: Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos. 1996 Sep;24(9):1015-9. - Pubmed
DTHybrid score 0.7885
Glutathione S-transferase P
Name Glutathione S-transferase P
Gene Name GSTP1
Actions substrate
References
  • Czerwinski M, Gibbs JP, Slattery JT: Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos. 1996 Sep;24(9):1015-9. - Pubmed
DTHybrid score 0.8002
Microsomal glutathione S-transferase 2
Name Microsomal glutathione S-transferase 2
Gene Name MGST2
Actions substrate
References
  • Harkey MA, Czerwinski M, Slattery J, Kiem HP: Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan. Cancer Invest. 2005;23(1):19-25. - Pubmed
DTHybrid score 0.277

Predictions


Id Partner name Gene Name Score
1313 Lactoylglutathione lyase GLO1 0.1517
901 Glutathione S-transferase Mu 4 GSTM4 0.1457
2165 Glutathione S-transferase Mu 2 GSTM2 0.1102
3759 Glutathione S-transferase gst 0.099
4541 Glutathione S-transferase GST 0.099
3947 Xanthine dehydrogenase/oxidase XDH 0.0725
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0724
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0677
1588 Multidrug resistance protein 1 ABCB1 0.0676
4119 Cytochrome P450 2D6 CYP2D6 0.0675
1405 Thiopurine S-methyltransferase TPMT 0.0658
2300 Lysozyme E 0.0636
3633 Lysozyme R 0.0636
5597 Lysozyme 17 0.0636
4118 Cytochrome P450 3A5 CYP3A5 0.0597
2314 Triosephosphate isomerase TPI 0.0595
3417 Triosephosphate isomerase tpiA 0.0595
3443 Triosephosphate isomerase tpiA 0.0595
6346 Triosephosphate isomerase TPI1 0.0595
908 Glutathione S-transferase theta-1 GSTT1 0.0577
4200 Cytochrome P450 1A2 CYP1A2 0.0495
4757 Cytochrome P450 2C9 CYP2C9 0.0492
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0466
6013 Cytochrome P450 2E1 CYP2E1 0.0455
4924 Cytochrome P450 2C8 CYP2C8 0.0454
5898 Complement C3 C3 0.0453
6016 Cytochrome P450 2C19 CYP2C19 0.0448
6024 Cytochrome P450 1A1 CYP1A1 0.0434
899 Glutathione S-transferase Mu 3 GSTM3 0.0433
6030 Cytochrome P450 2B6 CYP2B6 0.0431
905 Glutathione transferase omega-1 GSTO1 0.043
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0418
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0413
6677 Myelin P2 protein PMP2 0.0365
587 Serum albumin ALB 0.0364
903 Glutathione S-transferase A5 GSTA5 0.0361
6163 Copper-transporting ATPase 2 ATP7B 0.0358
6165 Copper-transporting ATPase 1 ATP7A 0.0358
4035 Glutathione S-transferase Mu 5 GSTM5 0.0349
2517 Subtilisin BPN' apr 0.0347
900 Glutathione S-transferase A4 GSTA4 0.0345
1928 Leukotriene C4 synthase LTC4S 0.0344
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0343
4029 Microsomal glutathione S-transferase 3 MGST3 0.0343
4034 Glutaredoxin-1 GLRX 0.0343
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0342
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0342
4040 Glutathione peroxidase 7 GPX7 0.0342
4032 Microsomal glutathione S-transferase 1 MGST1 0.0342
6146 High affinity copper uptake protein 1 SLC31A1 0.0342
4037 Hypothetical protein GPX1 0.0342
4297 Hypothetical protein SP_1951 0.0342
4521 Hypothetical protein BC_2969 0.0342
4540 Hypothetical protein TM_1070 0.0342
4555 Hypothetical protein MT1739 0.0342
4569 Hypothetical protein mshD 0.0342
4578 Hypothetical protein PA3270 0.0342
4747 Hypothetical protein PA3967 0.0342
5177 Hypothetical protein TM_0096 0.0342
5194 Hypothetical protein PA1204 0.0342
5240 Hypothetical protein Rv2991 0.0342
5370 Hypothetical protein TM_1158 0.0342
5710 Hypothetical protein Tb927.5.1360 0.0342
906 Glutathione peroxidase 1 GPX1 0.0342
4036 Glutathione peroxidase 6 GPX6 0.0342
4042 Glutathione transferase omega-2 GSTO2 0.0342
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0342
907 Glutathione peroxidase 2 GPX2 0.0342
4038 Glutathione peroxidase 4 GPX4 0.0342
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0342
910 Epididymal secretory glutathione peroxidase GPX5 0.0342
911 Glutathione peroxidase 3 GPX3 0.0342
4033 S-formylglutathione hydrolase ESD 0.0342
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0342
6107 Cytochrome P450 3A7 CYP3A7 0.0324
2596 Acetyl-CoA acetyltransferase phbA 0.0317
898 Glutathione S-transferase A3 GSTA3 0.0314
897 Glutathione S-transferase kappa 1 GSTK1 0.0304
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0298
3319 Hydroxyacylglutathione hydrolase HAGH 0.0297
2443 Azurin azu 0.0291
909 Maleylacetoacetate isomerase GSTZ1 0.0283
468 Cytochrome P450 4A11 CYP4A11 0.0279
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0278
558 Solute carrier family 12 member 1 SLC12A1 0.0278
1757 Myeloperoxidase MPO 0.0266
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0266
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0264
5718 Cytochrome P450 2A6 CYP2A6 0.0264
1729 Solute carrier family 22 member 6 SLC22A6 0.0252
2112 Toll-like receptor 9 TLR9 0.0244
6136 Multidrug resistance-associated protein 5 ABCC5 0.0241
862 Multidrug resistance-associated protein 1 ABCC1 0.0239
207 Glutathione synthetase GSS 0.0235
5269 Glutathione synthetase gshB 0.0235
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0227
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0221
777 Tumor necrosis factor TNF 0.0214
714 Glutathione reductase, mitochondrial GSR 0.0191
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0179
86 SEC14-like protein 4 SEC14L4 0.0179
375 SEC14-like protein 3 SEC14L3 0.0179
4076 Diacylglycerol kinase alpha DGKA 0.0179
2164 Multidrug resistance-associated protein 4 ABCC4 0.017
6144 Solute carrier family 22 member 2 SLC22A2 0.0165
871 Glucocorticoid receptor NR3C1 0.0163
708 Alpha-tocopherol transfer protein TTPA 0.0159
283 SEC14-like protein 2 SEC14L2 0.0158
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0148
997 Protein kinase C beta type PRKCB 0.0146
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0142
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0139
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0137
1970 Protein kinase C alpha type PRKCA 0.0135
290 Prostaglandin G/H synthase 2 PTGS2 0.0134
20 Prostaglandin G/H synthase 1 PTGS1 0.0131
3811 Cytochrome P450 19A1 CYP19A1 0.013
1898 Cytochrome P450 1B1 CYP1B1 0.0129
824 Sodium-dependent serotonin transporter SLC6A4 0.0125
6145 Solute carrier family 22 member 1 SLC22A1 0.0123
492 Histamine H1 receptor HRH1 0.0123
6137 Multidrug resistance-associated protein 6 ABCC6 0.0121
275 Arachidonate 5-lipoxygenase ALOX5 0.012
810 Heme oxygenase 1 HMOX1 0.012
3391 Heme oxygenase 1 pbsA1 0.012
502 5-hydroxytryptamine 2A receptor HTR2A 0.0116
3923 Cholinesterase BCHE 0.0115
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0112
136 Estrogen receptor ESR1 0.0102
6147 Solute carrier family 22 member 3 SLC22A3 0.01
556 Alpha-1A adrenergic receptor ADRA1A 0.0091
590 5-hydroxytryptamine 2C receptor HTR2C 0.009
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0089
731 HIV-1 protease HIV-1 protease 0.0087
847 Mu-type opioid receptor OPRM1 0.0084
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0084
232 Corticosteroid-binding globulin SERPINA6 0.008
318 Alpha-2A adrenergic receptor ADRA2A 0.008
320 5-hydroxytryptamine 1A receptor HTR1A 0.0075
831 D(2) dopamine receptor DRD2 0.0075
6106 Cytochrome P450 2C18 CYP2C18 0.0071
467 Delta-type opioid receptor OPRD1 0.007
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0069
436 5-hydroxytryptamine 2B receptor HTR2B 0.0069
260 Cytochrome P450 51 ERG11 0.0069
761 Cytochrome P450 51 ERG11 0.0069
3163 Cytochrome P450 51 cyp51 0.0069
6432 Transporter snf 0.0069
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0068
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0066
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0066
817 DNA topoisomerase 2-alpha TOP2A 0.0065
614 Progesterone receptor PGR 0.0062
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
818 50S ribosomal protein L10 rplJ 0.0058
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0058
776 Bile salt export pump ABCB11 0.0058
632 Alpha-1B adrenergic receptor ADRA1B 0.0057
23 D(1A) dopamine receptor DRD1 0.0057
6148 Multidrug resistance-associated protein 7 ABCC10 0.0055
3709 Glycerol uptake facilitator protein glpF 0.0055
3116 Bacterioferritin bfr 0.0055
4906 Bacterioferritin bfr 0.0055
4965 Bacterioferritin bfr 0.0055
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0055
696 Kappa-type opioid receptor OPRK1 0.0055
3173 Enolase eno 0.0055
3393 TGF-beta receptor type-2 TGFBR2 0.0055
3238 Multidrug resistance protein mexA mexA 0.0055
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0055
341 5-hydroxytryptamine 3 receptor HTR3A 0.0053
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0051
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.005
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0049
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0049
6142 Solute carrier family 22 member 8 SLC22A8 0.0048
2852 DNA mismatch repair protein mutL mutL 0.0048
766 Beta-2 adrenergic receptor ADRB2 0.0048
474 Acetylcholinesterase ACHE 0.0048
4311 tRNA TRDMT1 0.0047
4325 tRNA trmD 0.0047
4328 tRNA trmD 0.0047
4192 DNA topoisomerase 2-beta TOP2B 0.0047
789 Alpha-1D adrenergic receptor ADRA1D 0.0047
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0047
713 Sodium-dependent dopamine transporter SLC6A3 0.0046
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0046
629 Alpha-2B adrenergic receptor ADRA2B 0.0045
6459 Glycodelin PAEP 0.0045
3221 Cytochrome c4 cc4 0.0045
3191 Histidinol dehydrogenase hisD 0.0044
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0044
118 Organic cation/carnitine transporter 2 SLC22A5 0.0043
885 5-hydroxytryptamine 1B receptor HTR1B 0.0042
6031 Cytochrome P450 3A43 CYP3A43 0.0042
378 Alpha-2C adrenergic receptor ADRA2C 0.0042
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0042
740 Argininosuccinate synthase ASS1 0.0041
865 Argininosuccinate synthase ASS1 0.0041
2680 Argininosuccinate synthase argG 0.0041
3194 Argininosuccinate synthase argG 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
638 D(3) dopamine receptor DRD3 0.0041
4692 A/G-specific adenine glycosylase mutY 0.004
29 Tubulin beta-1 chain TUBB1 0.004
952 Dipeptidyl peptidase 4 DPP4 0.004
725 5-hydroxytryptamine 1D receptor HTR1D 0.004
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0039
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0039
2802 Endoglucanase G celCCG 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0038
6316 ADP-ribosylation factor 1 ARF1 0.0038
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0037
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0036
444 Alcohol dehydrogenase 1B ADH1B 0.0036
6182 Cytochrome P450 2J2 CYP2J2 0.0036
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0036
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0036
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0035
5448 Ribonuclease Z rnz 0.0035
5449 Hypothetical gliding protein mglB 0.0035
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0035
4705 Manganese catalase Not Available 0.0035
5439 33 kDa chaperonin hslO 0.0035
332 Beta-lactamase blaZ 0.0035
2478 Beta-lactamase ampC 0.0035
2613 Beta-lactamase ampC 0.0035
2635 Beta-lactamase ampC 0.0035
2700 Beta-lactamase penP 0.0035
5445 Beta-lactamase blaB 0.0035
6019 Beta-lactamase SHV-7 0.0035
6701 Beta-lactamase cphA 0.0035
5443 UPF0189 protein ymdB ymdB 0.0035
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0035
5440 UPF0067 protein yebR yebR 0.0035
2720 Copper-containing nitrite reductase nirK 0.0035
5454 Internalin-A inlA 0.0035
856 Vitamin D3 receptor VDR 0.0035
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0035
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
6143 Solute carrier family 22 member 7 SLC22A7 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
811 Translocator protein TSPO 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
4498 Ornithine cyclodeaminase PP3533 0.0034
193 Beta-1 adrenergic receptor ADRB1 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0034
6020 Aldehyde oxidase AOX1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0033
814 Ryanodine receptor 1 RYR1 0.0033
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0032
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0032
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0032
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0032
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0032
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0032
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0032
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
146 Androgen receptor AR 0.0031
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0031
432 D(4) dopamine receptor DRD4 0.0031
5450 Prolyl endopeptidase Pep pep 0.0031
4771 Dissimilatory copper-containing nitrite reductase nir 0.0031
3356 Diaminopimelate decarboxylase lysA 0.0031
2714 Chorismate mutase aroH 0.0031
4611 Chorismate mutase aroG 0.0031
3274 Hydroxylamine reductase hcp 0.0031
4804 Hydroxylamine reductase hcp 0.0031
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
716 5-hydroxytryptamine 7 receptor HTR7 0.003
756 Sex hormone-binding globulin SHBG 0.0029
833 Organic cation/carnitine transporter 1 SLC22A4 0.0029
284 DNA-directed RNA polymerase beta chain rpoB 0.0029
5773 DNA-directed RNA polymerase beta chain rpoB 0.0029
3399 Limonene-1,2-epoxide hydrolase limA 0.0029
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0028
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0028
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0028
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0028
597 Dihydropteridine reductase QDPR 0.0028
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0028
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0028
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
4608 Putative cytochrome P450 SCO1207 0.0027
4963 Putative cytochrome P450 SCO2884 0.0027
6254 Putative cytochrome P450 SCO6998 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
5180 L(+)-mandelate dehydrogenase mdlB 0.0027
3500 Putative family 31 glucosidase yicI yicI 0.0027
295 Carbonic anhydrase 1 CA1 0.0027
3480 Mannan endo-1,4-beta-mannosidase manA 0.0027
577 Argininosuccinate lyase ASL 0.0026
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
1615 Chymase CMA1 0.0026
49 Endothelin B receptor EDNRB 0.0026
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0026
407 Vascular endothelial growth factor receptor 2 KDR 0.0025
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0025
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
4604 Liver carboxylesterase 1 CES1 0.0025
1024 Solute carrier family 22 member 11 SLC22A11 0.0024
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
705 Glutamate receptor 1 GRIA1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0023
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0023
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0023
844 Epidermal growth factor receptor EGFR 0.0023
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0023
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0023
869 Estrogen receptor beta ESR2 0.0023
70 Type-1 angiotensin II receptor AGTR1 0.0023
737 Mineralocorticoid receptor NR3C2 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0022
6220 Aryl hydrocarbon receptor AHR 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
1656 CYP2B protein CYP2B 0.0021
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0021
163 D(1B) dopamine receptor DRD5 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
6014 Cytochrome P450 2A13 CYP2A13 0.002
3941 Amine oxidase [flavin-containing] A MAOA 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
465 Calmodulin CALM1 0.002
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
373 Transthyretin TTR 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
124 Histamine H2 receptor HRH2 0.0018
4120 NADPH--cytochrome P450 reductase POR 0.0018
6102 Arylamine N-acetyltransferase 2 NAT2 0.0018
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0018
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
26 Vascular endothelial growth factor receptor 3 FLT4 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
683 Potassium transporter GK0582 0.0018
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0018
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0018
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0017
32 Vascular endothelial growth factor receptor 1 FLT1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
1050 Bile salt sulfotransferase SULT2A1 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0016
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0016
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0016
228 Beta platelet-derived growth factor receptor PDGFRB 0.0016
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
173 Toll-like receptor 7 TLR7 0.0016
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0016
3233 Bile acid receptor NR1H4 0.0015
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0015
3939 Amine oxidase [flavin-containing] B MAOB 0.0015
427 Substance-P receptor TACR1 0.0015
380 Cytochrome P450 17A1 CYP17A1 0.0015
1629 Transcription factor AP-1 JUN 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
1541 Metalloproteinase mmp20 0.0014
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0014
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
6141 Sodium/bile acid cotransporter SLC10A1 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
1010 Cytochrome P450 51A1 CYP51A1 0.0014
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0014
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
4122 Histone deacetylase 2 HDAC2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
16 Adenosine A1 receptor ADORA1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
1178 Adenosine A2a receptor ADORA2A 0.0011
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0011
239 Coagulation factor X F10 0.0011
528 5-hydroxytryptamine 1E receptor HTR1E 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
365 Dihydrofolate reductase DHFR 0.0011
2381 Dihydrofolate reductase DFR1 0.0011
2833 Dihydrofolate reductase Not Available 0.0011
2931 Dihydrofolate reductase folA 0.0011
3544 Dihydrofolate reductase folA 0.0011
3682 Dihydrofolate reductase folA 0.0011
6642 Dihydrofolate reductase folA 0.0011
6756 Dihydrofolate reductase dfrA 0.0011
921 Glutamate receptor 2 GRIA2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0011
5787 Angiopoietin-1 receptor TEK 0.0011
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
54 Prothrombin F2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4203 Histamine N-methyltransferase HNMT 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
4773 Deoxycytidine kinase DCK 0.0009
1517 Beta-3 adrenergic receptor ADRB3 0.0009
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0009
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
165 FL cytokine receptor FLT3 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
183 Vascular endothelial growth factor A VEGFA 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
1593 Mucin-2 MUC2 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
738 Monocarboxylate transporter 1 SLC16A1 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
469 Annexin A1 ANXA1 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
2298 Cytochrome P450-cam camC 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
164 Histamine H4 receptor HRH4 0.0007
125 DNA polymerase beta POLB 0.0007
1618 High affinity nerve growth factor receptor NTRK1 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
3937 Fatty-acid amide hydrolase FAAH 0.0006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0006
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0006
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0006
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0006
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
3809 Estrogen-related receptor gamma ESRRG 0.0006
273 Apoptosis regulator Bcl-2 BCL2 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
6085 Fatty acid-binding protein, intestinal FABP2 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0006
563 Thyroid peroxidase TPO 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
634 Squalene monooxygenase SQLE 0.0006
7196 Squalene monooxygenase ERG1 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1341 Histamine H3 receptor HRH3 0.0005
84 Nuclear receptor 0B1 NR0B1 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
1192 Sulfotransferase 1A1 SULT1A1 0.0005
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
823 Fibroblast growth factor receptor 2 FGFR2 0.0005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0005
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0005
3810 Catechol O-methyltransferase COMT 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
7 Nitric oxide synthase, inducible NOS2 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
1992 Vitamin D-binding protein GC 0.0004
319 Opioid receptor, sigma 1 OPRS1 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
4103 Proteasome subunit beta type 2 PSMB2 0.0004
4101 Proteasome subunit beta type 1 PSMB1 0.0004
4102 Proteasome subunit beta type 5 PSMB5 0.0004
1630 Integrin beta-2 ITGB2 0.0004
976 Platelet glycoprotein IX GP9 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
174 Sigma 1-type opioid receptor SIGMAR1 0.0004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0003
6044 Serum paraoxonase/lactonase 3 PON3 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
572 Integrin alpha-L ITGAL 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0003
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
1864 RET proto-oncogene RET 0.0003
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
1275 Estrogen sulfotransferase SULT1E1 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
517 Alcohol dehydrogenase 1C ADH1C 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
5934 Cytochrome P450 26A1 CYP26A1 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
751 Potassium channel subfamily K member 6 KCNK6 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
172 Potassium channel subfamily K member 1 KCNK1 0.0002
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0002
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
3957 Adenosine deaminase ADA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
162 Retinoic acid receptor gamma-1 RARG 0.0002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0002
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
2207 Rhodopsin RHO 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
2981 Phospholipase A2, membrane associated PLA2G2A 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0001
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0001
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
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