DT-Web: DB00927

Identification

Name

Famotidine

Accession Number

DB00927 (APRD00296)

Type

small molecule

Description

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

337.445

Groups

approved

Monoisotopic Weight

337.044934829

Pharmacology

Indication

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Mechanism of action

Famotidine binds competitively to H₂-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

Absorption

The bioavailability of oral doses is 40-45%.

Protein binding

15-20%

Biotransformation

Hepatic.

Route of elimination

Renal clearance is 250-450 mL/min, indicating some tubular excretion.

Toxicity

Intravenous, mouse: LD₅₀ = 244.4mg/kg; Oral, mouse: LD₅₀ = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	This gastric pH modifier decreases the levels/effects of atazanavir
Cefditoren	H2-Antagonists such as famotidine may decrease the serum concentration of cefditoren. Cefditoren prescribing information recommends to avoid concomitant use with H2-antagonists (eg, famotidine, ranitidine) and antacids as well. Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of H2-antagonists can not be avoided.
Enoxacin	Famotidine may decrease the absorption of enoxacin.
Itraconazole	The H2-receptor antagonist, famotidine, may decrease the absorption of itraconazole.
Ketoconazole	The H2-receptor antagonist, famotidine, may decrease the absorption of ketoconazole.
Rilpivirine	Histamine-2 receptor antagonists increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.

Food Interactions

Take without regard to meals, food may slightly increase the product's bioavailability.
Limit caffeine intake.
Avoid alcohol.

Histamine H2 receptor
Name	Histamine H2 receptor
Gene Name	HRH2
Pharmacological action	yes
Actions	antagonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Fukuda M, Tanaka S, Suzuki S, Kusama K, Kaneko T, Sakashita H: Cimetidine induces apoptosis of human salivary gland tumor cells. Oncol Rep. 2007 Mar;17(3):673-8. - Pubmed Takahashi HK, Watanabe T, Yokoyama A, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. Epub 2006 May 24. - Pubmed Kesiova M, Alexandrova A, Yordanova N, Kirkova M, Todorov S: Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues. Pharmacol Rep. 2006 Mar-Apr;58(2):221-8. - Pubmed Lesclous P, Schramm F, Gallina S, Baroukh B, Guez D, Saffar JL: Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats. Exp Physiol. 2006 May;91(3):561-70. Epub 2006 Mar 2. - Pubmed Amagase K, Okabe S: On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion. J Pharmacol Sci. 2003 Jun;92(2):124-36. - Pubmed Weydert JA, Ball TM, Davis MF: Systematic review of treatments for recurrent abdominal pain. Pediatrics. 2003 Jan;111(1):e1-11. - Pubmed Miyata K, Kamato T, Nishida A, Honda K: Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol. 1991 Feb;55(2):211-22. - Pubmed Leurs R, Brozius MM, Smit MJ, Bast A, Timmerman H: Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine. Br J Pharmacol. 1991 Jan;102(1):179-85. - Pubmed Inan A, Sen M, Surgit O, Ergin M, Bozer M: Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo). 2009;64(6):567-70. - Pubmed Ojiako K, Shingala H, Schorr C, Gerber DR: Famotidine versus pantoprazole for preventing bleeding in the upper gastrointestinal tract of critically ill patients receiving mechanical ventilation. Am J Crit Care. 2008 Mar;17(2):142-7. - Pubmed
DTHybrid score	0.5744

Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2128

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. - Pubmed
DTHybrid score	0.1849
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate,inhibitor
References	Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. - Pubmed Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. - Pubmed Tahara H, Kusuhara H, Chida M, Fuse E, Sugiyama Y: Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists. J Pharmacol Exp Ther. 2006 Mar;316(3):1187-94. Epub 2005 Nov 16. - Pubmed
DTHybrid score	0.2109

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.1278
4757	Cytochrome P450 2C9	CYP2C9	0.1158
6145	Solute carrier family 22 member 1	SLC22A1	0.1045
1588	Multidrug resistance protein 1	ABCB1	0.1018
4119	Cytochrome P450 2D6	CYP2D6	0.0997
1729	Solute carrier family 22 member 6	SLC22A6	0.0927
4200	Cytochrome P450 1A2	CYP1A2	0.0811
1024	Solute carrier family 22 member 11	SLC22A11	0.0712
4924	Cytochrome P450 2C8	CYP2C8	0.061
4118	Cytochrome P450 3A5	CYP3A5	0.0596
118	Organic cation/carnitine transporter 2	SLC22A5	0.0555
6143	Solute carrier family 22 member 7	SLC22A7	0.0551
6147	Solute carrier family 22 member 3	SLC22A3	0.0515
6030	Cytochrome P450 2B6	CYP2B6	0.0488
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0444
587	Serum albumin	ALB	0.0393
6013	Cytochrome P450 2E1	CYP2E1	0.0391
6107	Cytochrome P450 3A7	CYP3A7	0.0355
833	Organic cation/carnitine transporter 1	SLC22A4	0.0348
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0327
492	Histamine H1 receptor	HRH1	0.0325
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0312
3923	Cholinesterase	BCHE	0.0307
20	Prostaglandin G/H synthase 1	PTGS1	0.0302
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0287
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0284
6024	Cytochrome P450 1A1	CYP1A1	0.0283
2164	Multidrug resistance-associated protein 4	ABCC4	0.0267
5718	Cytochrome P450 2A6	CYP2A6	0.0255
766	Beta-2 adrenergic receptor	ADRB2	0.0246
556	Alpha-1A adrenergic receptor	ADRA1A	0.0235
776	Bile salt export pump	ABCB11	0.0225
862	Multidrug resistance-associated protein 1	ABCC1	0.0221
318	Alpha-2A adrenergic receptor	ADRA2A	0.0207
6106	Cytochrome P450 2C18	CYP2C18	0.0207
193	Beta-1 adrenergic receptor	ADRB1	0.0206
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0203
290	Prostaglandin G/H synthase 2	PTGS2	0.0202
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0197
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0195
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0194
824	Sodium-dependent serotonin transporter	SLC6A4	0.0184
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0176
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0172
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0161
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.016
6136	Multidrug resistance-associated protein 5	ABCC5	0.0159
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0158
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0157
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0153
1341	Histamine H3 receptor	HRH3	0.0153
4203	Histamine N-methyltransferase	HNMT	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
378	Alpha-2C adrenergic receptor	ADRA2C	0.0149
831	D(2) dopamine receptor	DRD2	0.0144
164	Histamine H4 receptor	HRH4	0.0144
716	5-hydroxytryptamine 7 receptor	HTR7	0.0144
629	Alpha-2B adrenergic receptor	ADRA2B	0.014
617	Muscarinic acetylcholine receptor M2	CHRM2	0.014
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0129
6141	Sodium/bile acid cotransporter	SLC10A1	0.0125
3811	Cytochrome P450 19A1	CYP19A1	0.0122
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.012
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0118
1898	Cytochrome P450 1B1	CYP1B1	0.0116
789	Alpha-1D adrenergic receptor	ADRA1D	0.0116
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0115
2016	Dipeptidase 1	DPEP1	0.0115
7	Nitric oxide synthase, inducible	NOS2	0.0115
6148	Multidrug resistance-associated protein 7	ABCC10	0.0112
632	Alpha-1B adrenergic receptor	ADRA1B	0.0112
713	Sodium-dependent dopamine transporter	SLC6A3	0.0111
590	5-hydroxytryptamine 2C receptor	HTR2C	0.011
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0108
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0107
738	Monocarboxylate transporter 1	SLC16A1	0.0107
3947	Xanthine dehydrogenase/oxidase	XDH	0.0106
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0105
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0103
159	Penicillin-binding protein 2B	penA	0.0102
6121	Penicillin-binding protein 2B	penA	0.0102
22	30S ribosomal protein S4	rpsD	0.0101
6714	30S ribosomal protein S4	rpsD	0.0101
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.01
338	DNA polymerase	UL30	0.01
379	DNA polymerase	UL54	0.01
697	DNA polymerase	ORF28	0.01
2482	DNA polymerase	43	0.01
4104	DNA polymerase	BALF5	0.01
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0099
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0099
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0098
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0098
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0096
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0096
140	30S ribosomal protein S9	rpsI	0.0095
6719	30S ribosomal protein S9	rpsI	0.0095
6725	30S ribosomal protein S9	rpsI	0.0095
23	D(1A) dopamine receptor	DRD1	0.0095
3939	Amine oxidase [flavin-containing] B	MAOB	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
6137	Multidrug resistance-associated protein 6	ABCC6	0.0093
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0093
260	Cytochrome P450 51	ERG11	0.0092
761	Cytochrome P450 51	ERG11	0.0092
3163	Cytochrome P450 51	cyp51	0.0092
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0088
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0088
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0088
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0087
5626	Nucleoside diphosphate kinase B	NME2	0.0087
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0087
6010	Thiamine transporter 1	SLC19A2	0.0086
543	Penicillin-binding protein 1B	mrcB	0.0086
6186	Penicillin-binding protein 1B	ponB	0.0086
6822	Penicillin-binding protein 1b	pbp1b	0.0086
6844	Penicillin-binding protein 1b	pbp1b	0.0086
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0085
3941	Amine oxidase [flavin-containing] A	MAOA	0.0085
6020	Aldehyde oxidase	AOX1	0.0084
645	Penicillin-binding protein 1A	mrcA	0.0084
5805	Penicillin-binding protein 1A	ponA	0.0084
6185	Penicillin-binding protein 1A	mrcA	0.0084
6799	Penicillin-binding protein 1A	pbpA	0.0084
638	D(3) dopamine receptor	DRD3	0.0082
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0081
2472	Voltage-gated potassium channel	kcsA	0.008
6366	Voltage-gated potassium channel	kcsA	0.008
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.008
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
432	D(4) dopamine receptor	DRD4	0.0077
175	Thiamin pyrophosphokinase 1	TPK1	0.0077
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0077
146	Androgen receptor	AR	0.0076
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0075
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0074
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0072
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0072
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0072
5294	Nucleoside diphosphate kinase A	NME1	0.0071
438	Taste receptor type 1 member 2	TAS1R2	0.0071
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.007
731	HIV-1 protease	HIV-1 protease	0.007
4604	Liver carboxylesterase 1	CES1	0.0069
756	Sex hormone-binding globulin	SHBG	0.0068
817	DNA topoisomerase 2-alpha	TOP2A	0.0068
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0068
4773	Deoxycytidine kinase	DCK	0.0067
1757	Myeloperoxidase	MPO	0.0067
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0066
527	Prostacyclin receptor	PTGIR	0.0065
3686	Acyl-CoA thioesterase I precursor	tesA	0.0065
672	Prostaglandin F2-alpha receptor	PTGFR	0.0064
6167	Organic solute transporter subunit beta	OSTB	0.0064
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0064
6166	Organic solute transporter subunit alpha	OSTA	0.0064
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0063
5126	Arginase	rocF	0.0062
633	Penicillin-binding proteins 1A/1B	pbpA	0.0062
136	Estrogen receptor	ESR1	0.0062
6149	Solute carrier family 22 member 10	SLC22A10	0.0061
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0059
468	Cytochrome P450 4A11	CYP4A11	0.0058
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0058
887	DNA gyrase subunit B	gyrB	0.0057
4150	DNA gyrase subunit B	gyrB	0.0057
6225	DNA gyrase subunit B	gyrB	0.0057
558	Solute carrier family 12 member 1	SLC12A1	0.0057
465	Calmodulin	CALM1	0.0057
740	Argininosuccinate synthase	ASS1	0.0056
865	Argininosuccinate synthase	ASS1	0.0056
2680	Argininosuccinate synthase	argG	0.0056
3194	Argininosuccinate synthase	argG	0.0056
477	DNA topoisomerase 4 subunit A	parC	0.0056
886	DNA topoisomerase 4 subunit A	parC	0.0056
6226	DNA topoisomerase 4 subunit A	parC	0.0056
404	DNA gyrase subunit A	gyrA	0.0055
6224	DNA gyrase subunit A	gyrA	0.0055
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0055
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0055
1770	Phospholipase C	PLCL1	0.0055
2841	Phospholipase C	plc	0.0055
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0055
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0055
5353	Glutamate decarboxylase alpha	gadA	0.0054
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0054
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0054
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0053
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0052
4217	Telomerase reverse transcriptase	TERT	0.0052
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0051
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.005
624	Guanidinoacetate N-methyltransferase	GAMT	0.005
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.005
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.005
474	Acetylcholinesterase	ACHE	0.0049
2300	Lysozyme	E	0.0049
3633	Lysozyme	R	0.0049
5597	Lysozyme	17	0.0049
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0049
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
373	Transthyretin	TTR	0.0049
362	Melatonin receptor type 1B	MTNR1B	0.0048
571	Melatonin receptor type 1A	MTNR1A	0.0048
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0048
6070	Nischarin	NISCH	0.0048
6031	Cytochrome P450 3A43	CYP3A43	0.0047
6171	Solute carrier family 28 member 3	SLC28A3	0.0047
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0047
1405	Thiopurine S-methyltransferase	TPMT	0.0047
694	Matrix protein 2	M	0.0047
332	Beta-lactamase	blaZ	0.0046
2478	Beta-lactamase	ampC	0.0046
2613	Beta-lactamase	ampC	0.0046
2635	Beta-lactamase	ampC	0.0046
2700	Beta-lactamase	penP	0.0046
5445	Beta-lactamase	blaB	0.0046
6019	Beta-lactamase	SHV-7	0.0046
6701	Beta-lactamase	cphA	0.0046
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0045
183	Vascular endothelial growth factor A	VEGFA	0.0044
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0044
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0044
1517	Beta-3 adrenergic receptor	ADRB3	0.0043
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0043
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0043
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
3426	Glutamine synthetase	glnA	0.0042
3987	Glutamine synthetase	GLUL	0.0042
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0042
1830	5'-nucleotidase	NT5E	0.0042
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0042
161	Tubulin beta chain	TUBB	0.0041
312	Tubulin beta chain	TUB2	0.0041
6014	Cytochrome P450 2A13	CYP2A13	0.0041
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0041
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0041
125	DNA polymerase beta	POLB	0.004
131	Synaptic vesicular amine transporter	SLC18A2	0.004
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
2320	Thymidine kinase, cytosolic	TK1	0.004
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0039
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0039
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0039
6146	High affinity copper uptake protein 1	SLC31A1	0.0039
1867	Major prion protein	PRNP	0.0039
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0039
5482	Sialidase-2	NEU2	0.0039
6432	Transporter	snf	0.0038
122	P2Y purinoceptor 12	P2RY12	0.0038
163	D(1B) dopamine receptor	DRD5	0.0038
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0038
3685	Catabolite gene activator	crp	0.0038
4655	Adenylate cyclase	cyaC	0.0038
4759	Adenylate cyclase	cyaB2	0.0038
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0037
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0037
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0037
828	Phenylalanine-4-hydroxylase	PAH	0.0037
3109	Phenylalanine-4-hydroxylase	phhA	0.0037
6085	Fatty acid-binding protein, intestinal	FABP2	0.0036
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0036
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0036
723	Cytosolic phospholipase A2	PLA2G4A	0.0036
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0036
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0036
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0036
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0036
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0036
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0036
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0036
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0036
130	Prostacyclin synthase	PTGIS	0.0036
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0036
5682	Ribonuclease pancreatic	RNASE1	0.0035
3611	Cytidine deaminase	cdd	0.0035
3707	Cytidine deaminase	cdd	0.0035
4211	Cytidine deaminase	CDA	0.0035
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0035
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0035
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0035
6218	Pannexin-1	PANX1	0.0035
115	Penicillin-binding protein 2	mrdA	0.0035
6069	Penicillin-binding protein 2	mrdA	0.0035
6118	Penicillin-binding protein 2	penA	0.0035
6187	Penicillin-binding protein 2	pbpA	0.0035
6686	Penicillin-binding protein 2	pbp2	0.0035
6939	Penicillin-binding protein 2	mrdA	0.0035
7163	Penicillin-binding protein 2	pbpA	0.0035
509	Thymidine kinase	TK	0.0035
570	Thymidine kinase	TK	0.0035
2559	Thymidine kinase	TK	0.0035
3430	Thymidine kinase	tdk	0.0035
3518	Thymidine kinase	TK	0.0035
5301	Thymidine kinase	tdk	0.0035
5771	Thymidine kinase	ORF36	0.0035
7009	Thymidine kinase	ORF36	0.0035
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0034
4120	NADPH--cytochrome P450 reductase	POR	0.0034
6209	30S ribosomal protein S19	rpsS	0.0034
6712	30S ribosomal protein S19	rpsS	0.0034
6726	30S ribosomal protein S19	rpsS	0.0034
6207	30S ribosomal protein S14	rpsN	0.0034
594	Thyroxine-binding globulin	SERPINA7	0.0034
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0034
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0033
976	Platelet glycoprotein IX	GP9	0.0033
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0033
6163	Copper-transporting ATPase 2	ATP7B	0.0033
6165	Copper-transporting ATPase 1	ATP7A	0.0033
2249	Aspartate aminotransferase	aspC	0.0033
2671	Aspartate aminotransferase	aspC	0.0033
5490	Aspartate aminotransferase	Not Available	0.0033
4760	Mll3241 protein	mll3241	0.0032
1	Peptidoglycan synthetase ftsI	ftsI	0.0032
4155	Peptidoglycan synthetase ftsI	ftsI	0.0032
357	Carbonic anhydrase 2	CA2	0.0032
952	Dipeptidyl peptidase 4	DPP4	0.0032
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0032
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0032
65	Matrix metalloproteinase-9	Not Available	0.0032
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0032
6182	Cytochrome P450 2J2	CYP2J2	0.0032
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0031
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0031
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0031
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0031
758	Thyroid hormone receptor alpha	THRA	0.0031
6111	DNA polymerase epsilon subunit 4	POLE4	0.0031
6112	DNA polymerase epsilon subunit 3	POLE3	0.0031
380	Cytochrome P450 17A1	CYP17A1	0.0031
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0031
6110	DNA polymerase epsilon subunit 2	POLE2	0.0031
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0031
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0031
3830	Calreticulin	CALR	0.0031
6212	Tubulin gamma-1 chain	TUBG1	0.0031
6210	Tubulin delta chain	TUBD1	0.0031
6211	Tubulin epsilon chain	TUBE1	0.0031
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.003
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.003
908	Glutathione S-transferase theta-1	GSTT1	0.003
904	Glutathione S-transferase P	GSTP1	0.003
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.003
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.003
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.003
6033	High affinity interleukin-8 receptor A	CXCR1	0.0029
1198	Serum paraoxonase/arylesterase 1	PON1	0.0029
6223	Penicillin-binding protein 1C	pbpC	0.0029
751	Potassium channel subfamily K member 6	KCNK6	0.0029
1618	High affinity nerve growth factor receptor	NTRK1	0.0028
6034	Hydroxyindole O-methyltransferase	ASMT	0.0028
6035	Nuclear receptor ROR-beta	RORB	0.0028
6036	Eosinophil peroxidase	EPX	0.0028
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0028
346	Thyroid hormone receptor beta-1	THRB	0.0028
275	Arachidonate 5-lipoxygenase	ALOX5	0.0027
867	Penicillin-binding protein 3	pbpC	0.0027
6119	Penicillin-binding protein 3	pbp3	0.0027
7154	Penicillin-binding protein 3	pbp3	0.0027
7157	Penicillin-binding protein 3	LMHCC_2184	0.0027
7162	Penicillin-binding protein 3	pbpB	0.0027
7172	Penicillin-binding protein 3	pbp3	0.0027
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0027
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0027
49	Endothelin B receptor	EDNRB	0.0027
1654	Interleukin-1 beta	IL1B	0.0026
777	Tumor necrosis factor	TNF	0.0026
172	Potassium channel subfamily K member 1	KCNK1	0.0026
3810	Catechol O-methyltransferase	COMT	0.0026
896	Glutathione S-transferase Mu 1	GSTM1	0.0026
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0026
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0026
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0026
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0026
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0026
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0026
85	Growth hormone receptor	GHR	0.0025
578	Endothelin-1 receptor	EDNRA	0.0025
244	Angiotensin-converting enzyme	ACE	0.0025
614	Progesterone receptor	PGR	0.0025
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0025
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0025
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0025
765	Indoleamine 2,3-dioxygenase	IDO1	0.0025
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0025
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0025
504	Mast/stem cell growth factor receptor	KIT	0.0025
1864	RET proto-oncogene	RET	0.0024
663	Solute carrier family 12 member 4	SLC12A4	0.0024
53	Solute carrier family 12 member 5	SLC12A5	0.0024
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0024
1629	Transcription factor AP-1	JUN	0.0024
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0024
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0024
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0024
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0024
921	Glutamate receptor 2	GRIA2	0.0024
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0024
603	DNA polymerase alpha catalytic subunit	POLA1	0.0024
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0023
592	Carbonic anhydrase 4	CA4	0.0023
844	Epidermal growth factor receptor	EGFR	0.0023
153	Dopamine beta-hydroxylase	DBH	0.0023
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0023
310	Solute carrier family 12 member 2	SLC12A2	0.0023
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0023
2021	Thrombomodulin	THBD	0.0023
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0022
489	Monocarboxylate transporter 2	SLC16A7	0.0022
26	Vascular endothelial growth factor receptor 3	FLT4	0.0022
2449	Tubulin alpha-3 chain	TUBA1A	0.0022
2539	Tubulin alpha-1 chain	TUBA4A	0.0022
494	Caspase-1	CASP1	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
70	Type-1 angiotensin II receptor	AGTR1	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
6168	Solute carrier family 22 member 16	SLC22A16	0.0021
6151	Monocarboxylate transporter 10	SLC16A10	0.0021
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0021
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0021
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0021
32	Vascular endothelial growth factor receptor 1	FLT1	0.0021
551	Carnitine O-acetyltransferase	CRAT	0.0021
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0021
5300	Antigen peptide transporter 1	TAP1	0.0021
1507	Cytochrome c	CYCS	0.0021
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0021
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0021
696	Kappa-type opioid receptor	OPRK1	0.0021
3587	Gastrotropin	FABP6	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
702	UMP-CMP kinase	CMPK1	0.002
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.002
869	Estrogen receptor beta	ESR2	0.002
6220	Aryl hydrocarbon receptor	AHR	0.002
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0019
3926	Choline transporter-like protein 2	SLC44A2	0.0019
3925	Choline transporter-like protein 4	SLC44A4	0.0019
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0019
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0019
3927	Choline transporter-like protein 3	SLC44A3	0.0019
1686	Choline transporter-like protein 1	SLC44A1	0.0019
861	Choline kinase alpha	CHKA	0.0019
769	High-affinity choline transporter 1	SLC5A7	0.0019
700	Choline dehydrogenase, mitochondrial	CHDH	0.0019
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0019
576	Choline O-acetyltransferase	CHAT	0.0019
3922	Phospholipase D2	PLD2	0.0019
3924	Phospholipase D1	PLD1	0.0019
3760	Penicillin-binding protein 5 precursor	dacA	0.0019
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0019
1074	Urokinase-type plasminogen activator	PLAU	0.0019
467	Delta-type opioid receptor	OPRD1	0.0019
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
1656	CYP2B protein	CYP2B	0.0019
1039	Histone deacetylase 9	HDAC9	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
4192	DNA topoisomerase 2-beta	TOP2B	0.0019
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
2077	Caspase-3	CASP3	0.0018
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0018
1253	Interferon gamma	IFNG	0.0018
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0018
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0018
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0018
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0018
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0018
1010	Cytochrome P450 51A1	CYP51A1	0.0018
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0018
277	Purine nucleoside phosphorylase	PNP	0.0018
2870	Purine nucleoside phosphorylase	punA	0.0018
2945	Purine nucleoside phosphorylase	punA	0.0018
4659	Purine nucleoside phosphorylase	TM_1596	0.0018
4825	Purine nucleoside phosphorylase	TTHA1435	0.0018
427	Substance-P receptor	TACR1	0.0018
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0017
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0017
819	Penicillin-binding protein 4	dacB	0.0017
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0017
6102	Arylamine N-acetyltransferase 2	NAT2	0.0017
407	Vascular endothelial growth factor receptor 2	KDR	0.0017
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0017
6042	Prostaglandin reductase 2	PTGR2	0.0017
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0017
891	Dihydropteroate synthase	folP	0.0017
5359	Dihydropteroate synthase	folP	0.0017
7175	Dihydropteroate synthase	sulI	0.0017
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0016
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0016
365	Dihydrofolate reductase	DHFR	0.0016
2381	Dihydrofolate reductase	DFR1	0.0016
2833	Dihydrofolate reductase	Not Available	0.0016
2931	Dihydrofolate reductase	folA	0.0016
3544	Dihydrofolate reductase	folA	0.0016
3682	Dihydrofolate reductase	folA	0.0016
6642	Dihydrofolate reductase	folA	0.0016
6756	Dihydrofolate reductase	dfrA	0.0016
737	Mineralocorticoid receptor	NR3C2	0.0016
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0016
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0016
33	Cystine/glutamate transporter	SLC7A11	0.0016
847	Mu-type opioid receptor	OPRM1	0.0016
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0016
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0016
1792	Tissue-type plasminogen activator	PLAT	0.0016
823	Fibroblast growth factor receptor 2	FGFR2	0.0015
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0015
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0015
6043	Putative G-protein coupled receptor 44	GPR44	0.0015
273	Apoptosis regulator Bcl-2	BCL2	0.0015
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0015
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0015
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0015
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0015
2693	Heat-labile enterotoxin B chain	eltB	0.0014
199	Monocarboxylate transporter 8	SLC16A2	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0014
6126	Carbonic anhydrase 7	CA7	0.0014
4311	tRNA	TRDMT1	0.0013
4325	tRNA	trmD	0.0013
4328	tRNA	trmD	0.0013
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0013
106	Cannabinoid receptor 2	CNR2	0.0013
818	50S ribosomal protein L10	rplJ	0.0013
518	Peroxidase/catalase T	katG	0.0013
6174	50S ribosomal protein L32	rpmF	0.0013
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0013
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0013
4238	50S ribosomal protein L4	rplD	0.0013
5578	50S ribosomal protein L4	rplD	0.0013
6173	50S ribosomal protein L4	rplD	0.0013
6219	50S ribosomal protein L4	rplD	0.0013
1196	Complement decay-accelerating factor	CD55	0.0013
1313	Lactoylglutathione lyase	GLO1	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
871	Glucocorticoid receptor	NR3C1	0.0013
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0012
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0012
68	Cannabinoid receptor 1	CNR1	0.0012
563	Thyroid peroxidase	TPO	0.0012
811	Translocator protein	TSPO	0.0012
517	Alcohol dehydrogenase 1C	ADH1C	0.0012
3809	Estrogen-related receptor gamma	ESRRG	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0012
5818	Folate receptor alpha	FOLR1	0.0012
634	Squalene monooxygenase	SQLE	0.0012
7196	Squalene monooxygenase	ERG1	0.0012
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
2808	Chloramphenicol acetyltransferase 3	cat3	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
2391	Ferrochelatase	hemH	0.0011
6502	Ferrochelatase	DKFZp686P18130	0.0011
1591	Ferrochelatase, mitochondrial	FECH	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0011
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0011
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0011
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
295	Carbonic anhydrase 1	CA1	0.0011
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.001
3601	Dihydropteroate synthase 1	folP1	0.001
3807	Dihydropteroate synthase 1	folP1	0.001
3808	Dihydropteroate synthase 2	folP2	0.001
293	Gamma-glutamyl hydrolase	GGH	0.001
2417	Chloramphenicol acetyltransferase	cat	0.001
3278	Chloramphenicol acetyltransferase	cat	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
2810	Dr hemagglutinin structural subunit	draA	0.001
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.001
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.001
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.001
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.001
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.001
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.001
6493	Cytochrome c oxidase subunit 6C	COX6C	0.001
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.001
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.001
3913	Glutamic acid decarboxylase	GAD65	0.001
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.001
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.001
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.001
6559	Cytochrome c oxidase subunit 2	ctaC	0.001
6669	Cytochrome c oxidase subunit 2	ctaC	0.001
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.001
371	Cytochrome c oxidase subunit 1	MT-CO1	0.001
6558	Cytochrome c oxidase subunit 1	ctaD	0.001
581	Cytochrome P450 2R1	CYP2R1	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0009
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0009
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0009
1650	Heme carrier protein 1	SLC46A1	0.0009
1992	Vitamin D-binding protein	GC	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
319	Opioid receptor, sigma 1	OPRS1	0.0009
1483	Membrane copper amine oxidase	AOC3	0.0009
2540	Choloylglycine hydrolase	cbh	0.0009
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0009
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0009
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0009
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0009
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0009
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0009
1630	Integrin beta-2	ITGB2	0.0008
4103	Proteasome subunit beta type 2	PSMB2	0.0008
6501	Fatty acid-binding protein, liver	FABP1	0.0008
4102	Proteasome subunit beta type 5	PSMB5	0.0008
4101	Proteasome subunit beta type 1	PSMB1	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
735	Alanine aminotransferase 1	GPT	0.0008
3904	Alanine aminotransferase 2	GPT2	0.0008
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0008
94	5-hydroxytryptamine 4 receptor	HTR4	0.0008
239	Coagulation factor X	F10	0.0008
174	Sigma 1-type opioid receptor	SIGMAR1	0.0008
251	Alcohol dehydrogenase 1A	ADH1A	0.0008
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0007
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0007
820	Glycine receptor subunit alpha-2	GLRA2	0.0007
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0007
6500	Phospholipase A2	PLA2G1B	0.0007
6044	Serum paraoxonase/lactonase 3	PON3	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
856	Vitamin D3 receptor	VDR	0.0007
24	Thymidylate synthase	TMP1	0.0007
359	Thymidylate synthase	TYMS	0.0007
2626	Thymidylate synthase	thyA	0.0007
2729	Thymidylate synthase	thyA	0.0007
5352	Thymidylate synthase	THYA	0.0007
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0007
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0006
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0006
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0006
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0006
572	Integrin alpha-L	ITGAL	0.0006
5798	Mitogen-activated protein kinase 11	MAPK11	0.0006
267	Plasminogen activator inhibitor 1	SERPINE1	0.0006
482	Glycine receptor subunit alpha-1	GLRA1	0.0006
4122	Histone deacetylase 2	HDAC2	0.0006
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0006
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0006
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0006
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0006
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0006
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0006
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0006
5934	Cytochrome P450 26A1	CYP26A1	0.0006
6221	Steroid hormone receptor ERR1	ESRRA	0.0006
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0006
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0005
3937	Fatty-acid amide hydrolase	FAAH	0.0005
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0005
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0005
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0005
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0005
936	Ephrin type-A receptor 2	EPHA2	0.0005
165	FL cytokine receptor	FLT3	0.0005
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0005
84	Nuclear receptor 0B1	NR0B1	0.0005
5787	Angiopoietin-1 receptor	TEK	0.0005
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0005
1192	Sulfotransferase 1A1	SULT1A1	0.0005
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0005
6133	Sodium channel subunit beta-2	SCN2B	0.0005
6134	Sodium channel subunit beta-3	SCN3B	0.0005
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0005
6129	Carbonic anhydrase-related protein 11	CA11	0.0005
6132	Sodium channel subunit beta-1	SCN1B	0.0005
6135	Sodium channel subunit beta-4	SCN4B	0.0005
6127	Carbonic anhydrase-related protein	CA8	0.0005
6128	Carbonic anhydrase-related protein 10	CA10	0.0005
469	Annexin A1	ANXA1	0.0004
284	DNA-directed RNA polymerase beta chain	rpoB	0.0004
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0004
6130	Carbonic anhydrase 13	CA13	0.0004
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0004
6131	Carbonic anhydrase 14	CA14	0.0004
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0004
6122	Carbonic anhydrase 3	CA3	0.0004
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0004
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0003
3007	Carbonic anhydrase 12	CA12	0.0003
4205	Carbonic anhydrase 9	CA9	0.0003
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0003
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0003
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0003
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0003
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0003
291	Nitric-oxide synthase, endothelial	NOS3	0.0003
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00927 - Famotidine

Targets

Enzymes

Transporters

Predictions