DT-Web: DB00904

Identification

Name

Ondansetron

Accession Number

DB00904 (APRD00481)

Type

small molecule

Description

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

293.363

Groups

approved

Monoisotopic Weight

293.152812245

Pharmacology

Indication

For the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, postoperation, and radiation. Also used for the treatment of postoperative nausea and vomiting.

Mechanism of action

Ondansetron is a selective serotonin 5-HT₃ receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT₃ receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT₃ receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.

Absorption

Ondansetron is well absorbed after oral administration and undergoes limited first-pass metabolism.

Protein binding

70%-76% (Plasma protein binding)

Biotransformation

Hepatic

Route of elimination

Not Available

Toxicity

Low blood pressure and fainting, sudden blindness, severe constipation

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Asenapine	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Crizotinib	Concurrent use with crizotinib may decrease QTc interval. Consider alternative therapy.
Ezogabine	Concurrent use of ezogabine and ondansetron can increase QTc interval. Consider alternate therapy.
Indacaterol	Both indacaterol and ondansetron prolong the QT interval. Consider alternate therapy.
Pazopanib	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Telavancin	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.

Food Interactions

Take without regard to meals.

5-hydroxytryptamine 3 receptor
Name	5-hydroxytryptamine 3 receptor
Gene Name	HTR3A
Pharmacological action	yes
Actions	antagonist
References	Artaiz I, Zazpe A, Del Rio J: Characterization of serotonergic mechanisms involved in the behavioural inhibition induced by 5-hydroxytryptophan in a modified light-dark test in mice. Behav Pharmacol. 1998 Mar;9(2):103-12. - Pubmed Fortuno A, Ballaz S, Del Rio J, Barber A: CCK-mediated response in the activation of 5-HT receptor types in the guinea-pig ileum. J Physiol Biochem. 1999 Jun;55(2):85-92. - Pubmed Llacer JM, Gallardo V, Delgado R, Parraga J, Martin D, Ruiz MA: X-ray diffraction and electron microscopy in the polymorphism study of ondansetron hydrochloride. Drug Dev Ind Pharm. 2001 Oct;27(9):899-908. - Pubmed Carvalho F, Macedo D, Bandeira I, Maldonado I, Salles L, Azevedo MF, Rocha MA Jr, Fregoneze JB, De Castro-e-Silva E: Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats. Horm Metab Res. 2002 Feb;34(2):55-61. - Pubmed Arcioni R, della Rocca M, Romano S, Romano R, Pietropaoli P, Gasparetto A: Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans. Anesth Analg. 2002 Jun;94(6):1553-7, table of contents. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Gallardo Lara V, Gallardo ML, Morales Hernandez ME, Ruiz Martinez MA: Ondansetron: design and development of oral pharmaceutical suspensions. Pharmazie. 2009 Feb;64(2):90-3. - Pubmed Mohan KC, Ravikumar K: Ondansetron hydrochloride: a competitive serotonin 5-HT3 receptor blocker. Acta Crystallogr C. 1995 Dec 15;51 ( Pt 12):2627-9. - Pubmed Dimitrov DH: Effect of Ondansetron, a 5-HT(3) Receptor Antagonist, on Fatigue in 2 Veterans With Hepatitis C. Prim Care Companion J Clin Psychiatry. 2009;11(6):366-7. - Pubmed Szajewska H, Gieruszczak-Bialek D, Dylag M: Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children. Aliment Pharmacol Ther. 2007 Feb 15;25(4):393-400. - Pubmed Ramsook C, Sahagun-Carreon I, Kozinetz CA, Moro-Sutherland D: A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritis. Ann Emerg Med. 2002 Apr;39(4):397-403. - Pubmed Gregory RE, Ettinger DS: 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy. Drugs. 1998 Feb;55(2):173-89. - Pubmed Gan TJ: Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same? CNS Drugs. 2005;19(3):225-38. - Pubmed
DTHybrid score	0.2651
5-hydroxytryptamine 4 receptor
Name	5-hydroxytryptamine 4 receptor
Gene Name	HTR4
Pharmacological action	unknown
Actions	agonist
References	van Wijngaarden I, Tulp MT, Soudijn W: The concept of selectivity in 5-HT receptor research. Eur J Pharmacol. 1990 Jun 12;188(6):301-12. - Pubmed
DTHybrid score	0.2815
Mu-type opioid receptor
Name	Mu-type opioid receptor
Gene Name	OPRM1
Pharmacological action	unknown
Actions	other/unknown
References	van Wijngaarden I, Tulp MT, Soudijn W: The concept of selectivity in 5-HT receptor research. Eur J Pharmacol. 1990 Jun 12;188(6):301-12. - Pubmed
DTHybrid score	0.5135
5-hydroxytryptamine 1A receptor
Name	5-hydroxytryptamine 1A receptor
Gene Name	HTR1A
Pharmacological action	unknown
Actions	other/unknown
References	van Wijngaarden I, Tulp MT, Soudijn W: The concept of selectivity in 5-HT receptor research. Eur J Pharmacol. 1990 Jun 12;188(6):301-12. - Pubmed
DTHybrid score	0.3699
5-hydroxytryptamine 1B receptor
Name	5-hydroxytryptamine 1B receptor
Gene Name	HTR1B
Pharmacological action	unknown
Actions	other/unknown
References	van Wijngaarden I, Tulp MT, Soudijn W: The concept of selectivity in 5-HT receptor research. Eur J Pharmacol. 1990 Jun 12;188(6):301-12. - Pubmed
DTHybrid score	0.2534

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8435
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5475
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Janicki PK: Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit. 2005 Oct;11(10):RA322-8. Epub 2005 Sep 26. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6747
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4697
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.3912
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.513
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.342

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.3544
1588	Multidrug resistance protein 1	ABCB1	0.3053
4924	Cytochrome P450 2C8	CYP2C8	0.285
467	Delta-type opioid receptor	OPRD1	0.2718
696	Kappa-type opioid receptor	OPRK1	0.2566
502	5-hydroxytryptamine 2A receptor	HTR2A	0.2261
6030	Cytochrome P450 2B6	CYP2B6	0.2042
725	5-hydroxytryptamine 1D receptor	HTR1D	0.1652
831	D(2) dopamine receptor	DRD2	0.156
6024	Cytochrome P450 1A1	CYP1A1	0.1554
5718	Cytochrome P450 2A6	CYP2A6	0.1391
590	5-hydroxytryptamine 2C receptor	HTR2C	0.1278
318	Alpha-2A adrenergic receptor	ADRA2A	0.1213
492	Histamine H1 receptor	HRH1	0.112
824	Sodium-dependent serotonin transporter	SLC6A4	0.1022
23	D(1A) dopamine receptor	DRD1	0.1019
587	Serum albumin	ALB	0.1008
556	Alpha-1A adrenergic receptor	ADRA1A	0.1007
638	D(3) dopamine receptor	DRD3	0.0957
20	Prostaglandin G/H synthase 1	PTGS1	0.0919
629	Alpha-2B adrenergic receptor	ADRA2B	0.09
378	Alpha-2C adrenergic receptor	ADRA2C	0.0879
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0875
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0851
6145	Solute carrier family 22 member 1	SLC22A1	0.0843
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0834
432	D(4) dopamine receptor	DRD4	0.0817
766	Beta-2 adrenergic receptor	ADRB2	0.0813
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0803
193	Beta-1 adrenergic receptor	ADRB1	0.0769
632	Alpha-1B adrenergic receptor	ADRA1B	0.0754
511	5-hydroxytryptamine 1F receptor	HTR1F	0.075
3941	Amine oxidase [flavin-containing] A	MAOA	0.0741
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0701
716	5-hydroxytryptamine 7 receptor	HTR7	0.0672
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0655
163	D(1B) dopamine receptor	DRD5	0.0653
6106	Cytochrome P450 2C18	CYP2C18	0.064
6144	Solute carrier family 22 member 2	SLC22A2	0.0617
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0605
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0605
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0597
713	Sodium-dependent dopamine transporter	SLC6A3	0.0578
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0573
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0558
3811	Cytochrome P450 19A1	CYP19A1	0.0547
862	Multidrug resistance-associated protein 1	ABCC1	0.0536
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0504
1898	Cytochrome P450 1B1	CYP1B1	0.0487
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0485
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0484
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0475
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0472
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0458
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0458
290	Prostaglandin G/H synthase 2	PTGS2	0.0456
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0447
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.044
1729	Solute carrier family 22 member 6	SLC22A6	0.0436
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0428
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0421
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0418
380	Cytochrome P450 17A1	CYP17A1	0.0416
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0402
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.04
6031	Cytochrome P450 3A43	CYP3A43	0.0394
789	Alpha-1D adrenergic receptor	ADRA1D	0.0381
776	Bile salt export pump	ABCB11	0.0378
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0349
3923	Cholinesterase	BCHE	0.0343
1716	Tripartite motif-containing protein 13	TRIM13	0.0335
118	Organic cation/carnitine transporter 2	SLC22A5	0.0331
871	Glucocorticoid receptor	NR3C1	0.0312
136	Estrogen receptor	ESR1	0.0311
260	Cytochrome P450 51	ERG11	0.0308
761	Cytochrome P450 51	ERG11	0.0308
3163	Cytochrome P450 51	cyp51	0.0308
1517	Beta-3 adrenergic receptor	ADRB3	0.0302
731	HIV-1 protease	HIV-1 protease	0.0302
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0293
817	DNA topoisomerase 2-alpha	TOP2A	0.029
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0286
465	Calmodulin	CALM1	0.0286
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0273
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0268
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0267
6143	Solute carrier family 22 member 7	SLC22A7	0.0264
36	Insulin receptor	INSR	0.0258
2164	Multidrug resistance-associated protein 4	ABCC4	0.0258
1262	Corticotropin-lipotropin	POMC	0.0257
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0255
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0254
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0243
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.024
6147	Solute carrier family 22 member 3	SLC22A3	0.0236
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0232
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0231
468	Cytochrome P450 4A11	CYP4A11	0.0227
3939	Amine oxidase [flavin-containing] B	MAOB	0.0222
833	Organic cation/carnitine transporter 1	SLC22A4	0.022
6142	Solute carrier family 22 member 8	SLC22A8	0.0219
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0219
174	Sigma 1-type opioid receptor	SIGMAR1	0.0216
474	Acetylcholinesterase	ACHE	0.0213
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0207
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0207
6182	Cytochrome P450 2J2	CYP2J2	0.0201
477	DNA topoisomerase 4 subunit A	parC	0.0201
886	DNA topoisomerase 4 subunit A	parC	0.0201
6226	DNA topoisomerase 4 subunit A	parC	0.0201
404	DNA gyrase subunit A	gyrA	0.0198
6224	DNA gyrase subunit A	gyrA	0.0198
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0195
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0194
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0193
6148	Multidrug resistance-associated protein 7	ABCC10	0.0193
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0192
614	Progesterone receptor	PGR	0.0189
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0188
16	Adenosine A1 receptor	ADORA1	0.0185
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0185
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.018
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0179
811	Translocator protein	TSPO	0.0179
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0175
6220	Aryl hydrocarbon receptor	AHR	0.0171
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0171
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.017
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0168
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0167
891	Dihydropteroate synthase	folP	0.0166
5359	Dihydropteroate synthase	folP	0.0166
7175	Dihydropteroate synthase	sulI	0.0166
122	P2Y purinoceptor 12	P2RY12	0.0163
777	Tumor necrosis factor	TNF	0.0163
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0162
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0162
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.016
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0159
737	Mineralocorticoid receptor	NR3C2	0.0158
1178	Adenosine A2a receptor	ADORA2A	0.0158
319	Opioid receptor, sigma 1	OPRS1	0.0157
232	Corticosteroid-binding globulin	SERPINA6	0.0156
124	Histamine H2 receptor	HRH2	0.0152
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.015
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0148
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0145
4120	NADPH--cytochrome P450 reductase	POR	0.0144
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0144
705	Glutamate receptor 1	GRIA1	0.0141
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.014
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0139
1010	Cytochrome P450 51A1	CYP51A1	0.0139
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0138
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0137
4604	Liver carboxylesterase 1	CES1	0.0137
504	Mast/stem cell growth factor receptor	KIT	0.0136
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0135
6102	Arylamine N-acetyltransferase 2	NAT2	0.0133
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0132
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0132
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0132
1656	CYP2B protein	CYP2B	0.013
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0129
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0129
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0129
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0129
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0128
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0128
756	Sex hormone-binding globulin	SHBG	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
818	50S ribosomal protein L10	rplJ	0.0126
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0125
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0124
844	Epidermal growth factor receptor	EGFR	0.0122
482	Glycine receptor subunit alpha-1	GLRA1	0.0121
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.012
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
1024	Solute carrier family 22 member 11	SLC22A11	0.012
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.012
70	Type-1 angiotensin II receptor	AGTR1	0.0119
1757	Myeloperoxidase	MPO	0.0119
407	Vascular endothelial growth factor receptor 2	KDR	0.0118
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0117
6014	Cytochrome P450 2A13	CYP2A13	0.0116
3947	Xanthine dehydrogenase/oxidase	XDH	0.0116
146	Androgen receptor	AR	0.0115
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0115
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0115
4122	Histone deacetylase 2	HDAC2	0.0114
4137	Nociceptin receptor	OPRL1	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
29	Tubulin beta-1 chain	TUBB1	0.0112
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0112
6136	Multidrug resistance-associated protein 5	ABCC5	0.0111
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.011
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.011
26	Vascular endothelial growth factor receptor 3	FLT4	0.0108
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0108
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0107
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
4116	Dihydropteroate synthetase	Not Available	0.0106
295	Carbonic anhydrase 1	CA1	0.0106
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0105
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0105
427	Substance-P receptor	TACR1	0.0105
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0104
32	Vascular endothelial growth factor receptor 1	FLT1	0.0103
161	Tubulin beta chain	TUBB	0.0102
312	Tubulin beta chain	TUB2	0.0102
6020	Aldehyde oxidase	AOX1	0.0102
6137	Multidrug resistance-associated protein 6	ABCC6	0.0101
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0099
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0099
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0097
723	Cytosolic phospholipase A2	PLA2G4A	0.0096
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0096
869	Estrogen receptor beta	ESR2	0.0094
6141	Sodium/bile acid cotransporter	SLC10A1	0.0094
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0093
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0093
592	Carbonic anhydrase 4	CA4	0.0093
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0093
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0092
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0092
571	Melatonin receptor type 1A	MTNR1A	0.009
362	Melatonin receptor type 1B	MTNR1B	0.009
164	Histamine H4 receptor	HRH4	0.009
153	Dopamine beta-hydroxylase	DBH	0.0089
3810	Catechol O-methyltransferase	COMT	0.0089
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0088
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0088
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0088
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0088
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0087
365	Dihydrofolate reductase	DHFR	0.0087
2381	Dihydrofolate reductase	DFR1	0.0087
2833	Dihydrofolate reductase	Not Available	0.0087
2931	Dihydrofolate reductase	folA	0.0087
3544	Dihydrofolate reductase	folA	0.0087
3682	Dihydrofolate reductase	folA	0.0087
6642	Dihydrofolate reductase	folA	0.0087
6756	Dihydrofolate reductase	dfrA	0.0087
814	Ryanodine receptor 1	RYR1	0.0087
952	Dipeptidyl peptidase 4	DPP4	0.0087
273	Apoptosis regulator Bcl-2	BCL2	0.0085
768	FK506-binding protein 1A	FKBP1A	0.0083
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
173	Toll-like receptor 7	TLR7	0.0079
4237	50S ribosomal protein L22	rplV	0.0079
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0079
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0078
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0077
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0077
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0076
131	Synaptic vesicular amine transporter	SLC18A2	0.0076
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0074
1050	Bile salt sulfotransferase	SULT2A1	0.0074
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0074
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0073
275	Arachidonate 5-lipoxygenase	ALOX5	0.0072
790	DNA polymerase subunit alpha B	POLA2	0.0071
54	Prothrombin	F2	0.007
6126	Carbonic anhydrase 7	CA7	0.007
284	DNA-directed RNA polymerase beta chain	rpoB	0.007
5773	DNA-directed RNA polymerase beta chain	rpoB	0.007
1618	High affinity nerve growth factor receptor	NTRK1	0.007
357	Carbonic anhydrase 2	CA2	0.0069
49	Endothelin B receptor	EDNRB	0.0069
373	Transthyretin	TTR	0.0069
2112	Toll-like receptor 9	TLR9	0.0069
165	FL cytokine receptor	FLT3	0.0069
823	Fibroblast growth factor receptor 2	FGFR2	0.0068
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0068
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0068
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0068
921	Glutamate receptor 2	GRIA2	0.0067
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0066
4203	Histamine N-methyltransferase	HNMT	0.0066
578	Endothelin-1 receptor	EDNRA	0.0065
4238	50S ribosomal protein L4	rplD	0.0065
5578	50S ribosomal protein L4	rplD	0.0065
6173	50S ribosomal protein L4	rplD	0.0065
6219	50S ribosomal protein L4	rplD	0.0065
738	Monocarboxylate transporter 1	SLC16A1	0.0064
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0063
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0063
133	Dihydropterate synthase	sulI	0.0063
1192	Sulfotransferase 1A1	SULT1A1	0.0062
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
239	Coagulation factor X	F10	0.0062
1483	Membrane copper amine oxidase	AOC3	0.0062
976	Platelet glycoprotein IX	GP9	0.0062
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0062
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0062
6044	Serum paraoxonase/lactonase 3	PON3	0.0062
469	Annexin A1	ANXA1	0.0061
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0061
3932	Glutathione S-transferase A2	GSTA2	0.006
518	Peroxidase/catalase T	katG	0.006
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0059
2539	Tubulin alpha-1 chain	TUBA4A	0.0059
1852	Microtubule-associated protein 2	MAP2	0.0059
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0058
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0058
444	Alcohol dehydrogenase 1B	ADH1B	0.0058
904	Glutathione S-transferase P	GSTP1	0.0058
251	Alcohol dehydrogenase 1A	ADH1A	0.0057
1275	Estrogen sulfotransferase	SULT1E1	0.0057
780	Retinoic acid receptor RXR-gamma	RXRG	0.0057
3601	Dihydropteroate synthase 1	folP1	0.0057
3807	Dihydropteroate synthase 1	folP1	0.0057
3808	Dihydropteroate synthase 2	folP2	0.0057
84	Nuclear receptor 0B1	NR0B1	0.0057
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0056
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0056
563	Thyroid peroxidase	TPO	0.0055
6506	Stathmin-4	STMN4	0.0055
1291	cAMP response element-binding protein	CREB1	0.0054
183	Vascular endothelial growth factor A	VEGFA	0.0054
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0054
4311	tRNA	TRDMT1	0.0054
4325	tRNA	trmD	0.0054
4328	tRNA	trmD	0.0054
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0053
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0053
1629	Transcription factor AP-1	JUN	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
5923	Microtubule-associated protein tau	MAPT	0.0053
5924	Microtubule-associated protein 4	MAP4	0.0053
6432	Transporter	snf	0.0053
1196	Complement decay-accelerating factor	CD55	0.0052
712	Tubulin alpha chain	TUB1	0.0052
88	Retinoic acid receptor RXR-beta	RXRB	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
4773	Deoxycytidine kinase	DCK	0.005
6766	O-GlcNAcase BT_4395	BT_4395	0.0049
4210	Toll-like receptor 4	TLR4	0.0049
3404	Exotoxin A	eta	0.0049
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0048
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0047
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0047
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
33	Cystine/glutamate transporter	SLC7A11	0.0046
3086	Plasmepsin-2	Not Available	0.0046
856	Vitamin D3 receptor	VDR	0.0046
3913	Glutamic acid decarboxylase	GAD65	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
2808	Chloramphenicol acetyltransferase 3	cat3	0.0045
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6085	Fatty acid-binding protein, intestinal	FABP2	0.0045
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0045
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0045
2230	Catalase	CAT	0.0044
3249	Catalase	katA	0.0044
3625	Catalase	katA	0.0044
4539	Catalase	katA	0.0044
4941	Catalase	katB	0.0044
6043	Putative G-protein coupled receptor 44	GPR44	0.0044
517	Alcohol dehydrogenase 1C	ADH1C	0.0044
6138	Multidrug resistance protein 3	ABCB4	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0044
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0044
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
634	Squalene monooxygenase	SQLE	0.0043
7196	Squalene monooxygenase	ERG1	0.0043
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0043
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
1630	Integrin beta-2	ITGB2	0.0042
3809	Estrogen-related receptor gamma	ESRRG	0.0041
1648	Elastin	ELN	0.0041
6146	High affinity copper uptake protein 1	SLC31A1	0.0041
2417	Chloramphenicol acetyltransferase	cat	0.0041
3278	Chloramphenicol acetyltransferase	cat	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0041
2449	Tubulin alpha-3 chain	TUBA1A	0.0041
459	Retinoic acid receptor RXR-alpha	RXRA	0.0041
2810	Dr hemagglutinin structural subunit	draA	0.0041
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.004
908	Glutathione S-transferase theta-1	GSTT1	0.004
4192	DNA topoisomerase 2-beta	TOP2B	0.004
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
3937	Fatty-acid amide hydrolase	FAAH	0.004
3957	Adenosine deaminase	ADA	0.004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0039
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0039
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
1541	Metalloproteinase	mmp20	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
3904	Alanine aminotransferase 2	GPT2	0.0038
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
735	Alanine aminotransferase 1	GPT	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
24	Thymidylate synthase	TMP1	0.0038
359	Thymidylate synthase	TYMS	0.0038
2626	Thymidylate synthase	thyA	0.0038
2729	Thymidylate synthase	thyA	0.0038
5352	Thymidylate synthase	THYA	0.0038
1374	Natriuretic peptides B	NPPB	0.0038
1827	Gap junction alpha-1 protein	GJA1	0.0037
1908	Vascular cell adhesion protein 1	VCAM1	0.0037
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
7	Nitric oxide synthase, inducible	NOS2	0.0036
1864	RET proto-oncogene	RET	0.0036
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0036
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0036
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
3856	Fibroblast growth factor receptor 3	FGFR3	0.0035
6048	Troponin C, skeletal muscle	TNNC2	0.0035
5300	Antigen peptide transporter 1	TAP1	0.0035
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0034
751	Potassium channel subfamily K member 6	KCNK6	0.0034
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0033
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0033
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0033
6174	50S ribosomal protein L32	rpmF	0.0033
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0033
5934	Cytochrome P450 26A1	CYP26A1	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0032
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0032
268	Adenosine A2b receptor	ADORA2B	0.0032
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0032
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0032
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0032
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0032
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0032
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0031
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0031
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0031
572	Integrin alpha-L	ITGAL	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
172	Potassium channel subfamily K member 1	KCNK1	0.0031
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0031
65	Matrix metalloproteinase-9	Not Available	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.003
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
581	Cytochrome P450 2R1	CYP2R1	0.003
719	Retinoic acid receptor responder protein 1	RARRES1	0.003
770	Retinoic acid-induced protein 3	GPRC5A	0.003
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0029
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
2298	Cytochrome P450-cam	camC	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1650	Heme carrier protein 1	SLC46A1	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
162	Retinoic acid receptor gamma-1	RARG	0.0027
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0027
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0027
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
820	Glycine receptor subunit alpha-2	GLRA2	0.0027
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0026
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0026
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0026
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0026
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0026
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0026
5787	Angiopoietin-1 receptor	TEK	0.0026
569	Retinal dehydrogenase 2	ALDH1A2	0.0026
267	Plasminogen activator inhibitor 1	SERPINE1	0.0026
5880	Thrombopoietin receptor	MPL	0.0025
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0025
4103	Proteasome subunit beta type 2	PSMB2	0.0025
4102	Proteasome subunit beta type 5	PSMB5	0.0025
4101	Proteasome subunit beta type 1	PSMB1	0.0025
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0024
611	Retinal dehydrogenase 1	ALDH1A1	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
936	Ephrin type-A receptor 2	EPHA2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
358	Cystathionine beta-synthase	CBS	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
3639	Thymidine phosphorylase	deoA	0.0024
3936	Thymidine phosphorylase	TYMP	0.0024
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0024
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0024
6070	Nischarin	NISCH	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0023
896	Glutathione S-transferase Mu 1	GSTM1	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0023
6221	Steroid hormone receptor ERR1	ESRRA	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0023
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
6824	Tyrosine-protein kinase Lyn	LYN	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0021
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0021
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0021
2091	Endoplasmin	HSP90B1	0.0021
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1268	Neuropeptide S receptor	NPSR1	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
400	Coagulation factor IX	F9	0.0021
5461	Coagulation factor IX	F9	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
6149	Solute carrier family 22 member 10	SLC22A10	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
1820	Beta-nerve growth factor	NGF	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
2236	Casein kinase II subunit alpha	CSNK2A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0019
6163	Copper-transporting ATPase 2	ATP7B	0.0019
6165	Copper-transporting ATPase 1	ATP7A	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
6131	Carbonic anhydrase 14	CA14	0.0019
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0019
604	Vitamin K-dependent protein Z	PROZ	0.0019
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0019
1039	Histone deacetylase 9	HDAC9	0.0019
1992	Vitamin D-binding protein	GC	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
6122	Carbonic anhydrase 3	CA3	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
484	Tyrosine-protein kinase ABL2	ABL2	0.0017
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0017
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0017
422	Vitamin K-dependent protein C	PROC	0.0017
1245	Vitamin K-dependent protein S	PROS1	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
291	Nitric-oxide synthase, endothelial	NOS3	0.0017
106	Cannabinoid receptor 2	CNR2	0.0017
293	Gamma-glutamyl hydrolase	GGH	0.0017
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0017
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0016
144	Hemoglobin subunit alpha	HBA1	0.0016
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0016
1243	Cathepsin D	CTSD	0.0016
3830	Calreticulin	CALR	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
558	Solute carrier family 12 member 1	SLC12A1	0.0015
3221	Cytochrome c4	cc4	0.0015
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0015
1714	Mitogen-activated protein kinase 3	MAPK3	0.0015
6034	Hydroxyindole O-methyltransferase	ASMT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6035	Nuclear receptor ROR-beta	RORB	0.0015
6036	Eosinophil peroxidase	EPX	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
2207	Rhodopsin	RHO	0.0014
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0014
4226	Uridine phosphorylase 2	UPP2	0.0014
6167	Organic solute transporter subunit beta	OSTB	0.0014
6166	Organic solute transporter subunit alpha	OSTA	0.0014
798	Osteocalcin	BGLAP	0.0014
6859	Protein S100-A4	S100A4	0.0014
244	Angiotensin-converting enzyme	ACE	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
765	Indoleamine 2,3-dioxygenase	IDO1	0.0013
4225	Uridine phosphorylase 1	UPP1	0.0013
369	Coagulation factor VII	F7	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0012
760	Fibroblast growth factor 1	FGF1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
413	Amidophosphoribosyltransferase	PPAT	0.0012
2515	Amidophosphoribosyltransferase	purF	0.0012
3714	Amidophosphoribosyltransferase	purF	0.0012
1295	Fatty acid synthase	FASN	0.0012
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0011
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0011
4217	Telomerase reverse transcriptase	TERT	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
3007	Carbonic anhydrase 12	CA12	0.001
4205	Carbonic anhydrase 9	CA9	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
997	Protein kinase C beta type	PRKCB	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
2132	Protein S100-B	S100B	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
6459	Glycodelin	PAEP	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
1867	Major prion protein	PRNP	0.0008
4948	Cytochrome c-553	Not Available	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
6218	Pannexin-1	PANX1	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
2802	Endoglucanase G	celCCG	0.0007
822	Aldose reductase	AKR1B1	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
125	DNA polymerase beta	POLB	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
2021	Thrombomodulin	THBD	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1507	Cytochrome c	CYCS	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
76	Nitric-oxide synthase, brain	NOS1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
489	Monocarboxylate transporter 2	SLC16A7	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00904 - Ondansetron

Targets

Enzymes

Predictions