DT-Web

DB01259 - Lapatinib


Identification
Name Lapatinib
Accession Number DB01259 (DB02584)
Type small molecule
Description Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug Capecitabine. Lapatinib is human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1) tyrosine kinases inhibitor. It binds to the intracellular phosphorylation domain to prevent receptor autophosphorylation upon ligand binding.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 581.058
Groups approved
Monoisotopic Weight 580.134731942
Pharmacology
Indication Indicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress the human epidermal receptor type 2 (HER2) protein and who have received prior therapy including an anthracycline, a taxane, and trastuzuma.
Mechanism of action Lapatinib is a 4-anilinoquinazoline kinase inhibitor of the intracellular tyrosine kinase domains of both epidermal growth factor receptor (HER1/EGFR/ERBB1) and human epidermal growth factor receptor type 2 (HER2/ERBB2)with a dissociation half-life of ≥300 minutes. Lapatinib inhibits ERBB-driven tumor cell growth in vitro and in various animal models. An additive effect was demonstrated in an in vitro study when lapatinib and 5-florouracil (the active metabolite of capecitabine) were used in combination in the 4 tumor cell lines tested. The growth inhibitory effects of lapatinib were evaluated in trastuzumab-conditioned cell lines. Lapatinib retained significant activity against breast cancer cell lines selected for long-term growth in trastuzumab-containing medium in vitro. These in vitro findings suggest non-cross-resistance between these two agents.
Absorption Absorption following oral administration of lapatinib is incomplete and variable.
Protein binding Highly bound (>99%) to albumin and alpha-1 acid glycoprotein
Biotransformation Lapatinib undergoes extensive metabolism, primarily by CYP3A4 and CYP3A5, with minor contributions from CYP2C19 and CYP2C8 to a variety of oxidated metabolites, none of which accounts for more than 14% of the dose recovered in the feces or 10% of lapatinib concentration in plasma.
Route of elimination Lapatinib undergoes extensive metabolism, primarily by CYP3A4 and CYP3A5, with minor contributions from CYP2C19 and CYP2C8 to a variety of oxidated metabolites, none of which accounts for more than 14% of the dose recovered in the feces or 10% of lapatinib concentration in plasma.
Toxicity There has been a report of one patient who took 3,000 mg of lapatinib for 10 days. This patient had grade 3 diarrhea and vomiting on day 10.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Etravirine Lapatinib, when used concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to avoid this combination.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Pazopanib Lapatinib is a weak inhibitor of CYP3A4, BCRP, and p-glycoprotein and may increase exposure of pazopanib. AUC and Cmax increase by 50-60%.
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Tamsulosin Lapatinib, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Lapatinib is initiated, discontinued, or dose changed.
Telithromycin Telithromycin may reduce clearance of Lapatinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Lapatinib if Telithromycin is initiated, discontinued or dose changed.
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tolterodine Lapatinib may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Topotecan The p-glycoprotein inhibitor, Lapatinib, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol Lapatinib may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inhibitor, Lapatinib, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Lapatinib is initiated, discontinued or dose changed.
Tretinoin The moderate CYP2C8 inhibitor, Lapatinib, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Lapatinib is initiated, discontinued to dose changed.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of lapatinib by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of lapatinib if voriconazole is initiated, discontinued or dose changed.
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions Not Available

Targets


Epidermal growth factor receptor
Name Epidermal growth factor receptor
Gene Name EGFR
Pharmacological action yes
Actions antagonist
References
  • Xia W, Mullin RJ, Keith BR, Liu LH, Ma H, Rusnak DW, Owens G, Alligood KJ, Spector NL: Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene. 2002 Sep 12;21(41):6255-63. - Pubmed
  • Grana TM, Sartor CI, Cox AD: Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance. Cancer Res. 2003 Nov 15;63(22):7807-14. - Pubmed
  • Xia W, Liu LH, Ho P, Spector NL: Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. Oncogene. 2004 Jan 22;23(3):646-53. - Pubmed
  • Zhou H, Kim YS, Peletier A, McCall W, Earp HS, Sartor CI: Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):344-52. - Pubmed
  • Langer CJ: Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC. Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):991-1002. - Pubmed
  • Burris HA 3rd: Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. Oncologist. 2004;9 Suppl 3:10-5. - Pubmed
  • Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Dickerson SH, Ellis B, Pennisi C, Horne E, Lackey K, Alligood KJ, Rusnak DW, Gilmer TM, Shewchuk L: A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004 Sep 15;64(18):6652-9. - Pubmed
  • Vazquez-Martin A, Oliveras-Ferraros C, Cufi S, Barco SD, Martin-Castillo B, Menendez JA: Lapatinib, a dual HER1/HER2 tyrosine kinase inhibitor, augments basal cleavage of HER2 extracellular domain (ECD) to inhibit HER2-driven cancer cell growth. J Cell Physiol. 2010 Jul 23. - Pubmed
  • Johnston SR, Leary A: Lapatinib: a novel EGFR/HER2 tyrosine kinase inhibitor for cancer. Drugs Today (Barc). 2006 Jul;42(7):441-53. - Pubmed
  • Tevaarwerk AJ, Kolesar JM: Lapatinib: a small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer. Clin Ther. 2009;31 Pt 2:2332-48. - Pubmed
  • Medina PJ, Goodin S: Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Ther. 2008 Aug;30(8):1426-47. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7311
Receptor tyrosine-protein kinase erbB-2
Name Receptor tyrosine-protein kinase erbB-2
Gene Name ERBB2
Pharmacological action yes
Actions antagonist
References
  • Xia W, Liu LH, Ho P, Spector NL: Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. Oncogene. 2004 Jan 22;23(3):646-53. - Pubmed
  • Zhou H, Kim YS, Peletier A, McCall W, Earp HS, Sartor CI: Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):344-52. - Pubmed
  • Langer CJ: Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC. Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):991-1002. - Pubmed
  • Burris HA 3rd: Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. Oncologist. 2004;9 Suppl 3:10-5. - Pubmed
  • Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Dickerson SH, Ellis B, Pennisi C, Horne E, Lackey K, Alligood KJ, Rusnak DW, Gilmer TM, Shewchuk L: A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004 Sep 15;64(18):6652-9. - Pubmed
  • Grana TM, Sartor CI, Cox AD: Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance. Cancer Res. 2003 Nov 15;63(22):7807-14. - Pubmed
  • Xia W, Mullin RJ, Keith BR, Liu LH, Ma H, Rusnak DW, Owens G, Alligood KJ, Spector NL: Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene. 2002 Sep 12;21(41):6255-63. - Pubmed
  • Vazquez-Martin A, Oliveras-Ferraros C, Cufi S, Barco SD, Martin-Castillo B, Menendez JA: Lapatinib, a dual HER1/HER2 tyrosine kinase inhibitor, augments basal cleavage of HER2 extracellular domain (ECD) to inhibit HER2-driven cancer cell growth. J Cell Physiol. 2010 Jul 23. - Pubmed
  • Johnston SR, Leary A: Lapatinib: a novel EGFR/HER2 tyrosine kinase inhibitor for cancer. Drugs Today (Barc). 2006 Jul;42(7):441-53. - Pubmed
  • Tevaarwerk AJ, Kolesar JM: Lapatinib: a small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer. Clin Ther. 2009;31 Pt 2:2332-48. - Pubmed
  • Medina PJ, Goodin S: Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Ther. 2008 Aug;30(8):1426-47. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.8451

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Medina PJ, Goodin S: Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Ther. 2008 Aug;30(8):1426-47. - Pubmed
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
  • Teng WC, Oh JW, New LS, Wahlin MD, Nelson SD, Ho HK, Chan EC: Mechanism-Based Inactivation of Cytochrome P450 3A4 by Lapatinib. Mol Pharmacol. 2010 Jul 12. - Pubmed
DTHybrid score 0.644
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Medina PJ, Goodin S: Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Ther. 2008 Aug;30(8):1426-47. - Pubmed
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
DTHybrid score 0.4104
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Medina PJ, Goodin S: Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Ther. 2008 Aug;30(8):1426-47. - Pubmed
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
DTHybrid score 0.3472
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Medina PJ, Goodin S: Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Ther. 2008 Aug;30(8):1426-47. - Pubmed
  • van Erp NP, Gelderblom H, Guchelaar HJ: Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5. - Pubmed
DTHybrid score 0.3846

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Dai CL, Tiwari AK, Wu CP, Su XD, Wang SR, Liu DG, Ashby CR Jr, Huang Y, Robey RW, Liang YJ, Chen LM, Shi CJ, Ambudkar SV, Chen ZS, Fu LW: Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Res. 2008 Oct 1;68(19):7905-14. - Pubmed
DTHybrid score 0.5207
Antigen peptide transporter 1
Name Antigen peptide transporter 1
Gene Name TAP1
Actions inhibitor
References
  • Dai CL, Tiwari AK, Wu CP, Su XD, Wang SR, Liu DG, Ashby CR Jr, Huang Y, Robey RW, Liang YJ, Chen LM, Shi CJ, Ambudkar SV, Chen ZS, Fu LW: Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Res. 2008 Oct 1;68(19):7905-14. - Pubmed
DTHybrid score 0.2166

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.2799
4119 Cytochrome P450 2D6 CYP2D6 0.2447
6107 Cytochrome P450 3A7 CYP3A7 0.1875
4200 Cytochrome P450 1A2 CYP1A2 0.1853
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1719
6030 Cytochrome P450 2B6 CYP2B6 0.1333
6013 Cytochrome P450 2E1 CYP2E1 0.103
587 Serum albumin ALB 0.0967
6024 Cytochrome P450 1A1 CYP1A1 0.0919
5718 Cytochrome P450 2A6 CYP2A6 0.0721
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0697
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0595
20 Prostaglandin G/H synthase 1 PTGS1 0.0593
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0587
862 Multidrug resistance-associated protein 1 ABCC1 0.0565
6106 Cytochrome P450 2C18 CYP2C18 0.0558
3811 Cytochrome P450 19A1 CYP19A1 0.0556
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0524
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0515
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0461
2782 Complement C1s subcomponent C1S 0.0427
492 Histamine H1 receptor HRH1 0.0408
1898 Cytochrome P450 1B1 CYP1B1 0.0395
3817 Complement C1q subcomponent subunit C C1QC 0.0391
3816 Complement C1q subcomponent subunit B C1QB 0.0391
3815 Complement C1q subcomponent subunit A C1QA 0.0391
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0387
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0386
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0386
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0386
3814 Complement C1r subcomponent C1R 0.0386
871 Glucocorticoid receptor NR3C1 0.0385
824 Sodium-dependent serotonin transporter SLC6A4 0.0385
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0382
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.037
1729 Solute carrier family 22 member 6 SLC22A6 0.0369
6145 Solute carrier family 22 member 1 SLC22A1 0.0343
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0336
776 Bile salt export pump ABCB11 0.0326
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0322
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0313
6144 Solute carrier family 22 member 2 SLC22A2 0.0311
556 Alpha-1A adrenergic receptor ADRA1A 0.0304
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0298
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0295
290 Prostaglandin G/H synthase 2 PTGS2 0.0294
831 D(2) dopamine receptor DRD2 0.0292
502 5-hydroxytryptamine 2A receptor HTR2A 0.0285
136 Estrogen receptor ESR1 0.0272
731 HIV-1 protease HIV-1 protease 0.0271
847 Mu-type opioid receptor OPRM1 0.0269
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0268
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0261
260 Cytochrome P450 51 ERG11 0.0258
761 Cytochrome P450 51 ERG11 0.0258
3163 Cytochrome P450 51 cyp51 0.0258
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0256
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0254
6142 Solute carrier family 22 member 8 SLC22A8 0.025
6031 Cytochrome P450 3A43 CYP3A43 0.0247
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0242
6143 Solute carrier family 22 member 7 SLC22A7 0.0235
320 5-hydroxytryptamine 1A receptor HTR1A 0.0233
118 Organic cation/carnitine transporter 2 SLC22A5 0.0232
6182 Cytochrome P450 2J2 CYP2J2 0.0232
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0232
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0232
467 Delta-type opioid receptor OPRD1 0.0231
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0221
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0221
766 Beta-2 adrenergic receptor ADRB2 0.0218
2164 Multidrug resistance-associated protein 4 ABCC4 0.0217
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0216
696 Kappa-type opioid receptor OPRK1 0.021
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0209
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0209
632 Alpha-1B adrenergic receptor ADRA1B 0.0209
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0206
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0205
318 Alpha-2A adrenergic receptor ADRA2A 0.0202
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0202
5787 Angiopoietin-1 receptor TEK 0.0201
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0198
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0197
23 D(1A) dopamine receptor DRD1 0.019
504 Mast/stem cell growth factor receptor KIT 0.0184
193 Beta-1 adrenergic receptor ADRB1 0.0182
817 DNA topoisomerase 2-alpha TOP2A 0.0181
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0181
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.018
614 Progesterone receptor PGR 0.018
713 Sodium-dependent dopamine transporter SLC6A3 0.0178
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0176
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0176
468 Cytochrome P450 4A11 CYP4A11 0.0175
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0172
3950 Cell division protein kinase 9 CDK9 0.0171
3968 Cell division protein kinase 8 CDK8 0.0171
590 5-hydroxytryptamine 2C receptor HTR2C 0.017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.017
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0169
146 Androgen receptor AR 0.0168
183 Vascular endothelial growth factor A VEGFA 0.0167
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0162
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.016
3923 Cholinesterase BCHE 0.0157
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0155
638 D(3) dopamine receptor DRD3 0.0154
341 5-hydroxytryptamine 3 receptor HTR3A 0.0154
6148 Multidrug resistance-associated protein 7 ABCC10 0.0153
3941 Amine oxidase [flavin-containing] A MAOA 0.0151
6147 Solute carrier family 22 member 3 SLC22A3 0.0151
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0151
3959 Cell division protein kinase 4 CDK4 0.015
789 Alpha-1D adrenergic receptor ADRA1D 0.0148
3482 Cell division protein kinase 7 CDK7 0.0148
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0147
122 P2Y purinoceptor 12 P2RY12 0.0146
885 5-hydroxytryptamine 1B receptor HTR1B 0.0141
465 Calmodulin CALM1 0.0141
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0139
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0138
3955 Cell division protein kinase 6 CDK6 0.0138
232 Corticosteroid-binding globulin SERPINA6 0.0137
4604 Liver carboxylesterase 1 CES1 0.0136
737 Mineralocorticoid receptor NR3C2 0.0136
6137 Multidrug resistance-associated protein 6 ABCC6 0.0134
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0133
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0132
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0132
725 5-hydroxytryptamine 1D receptor HTR1D 0.013
6141 Sodium/bile acid cotransporter SLC10A1 0.013
1024 Solute carrier family 22 member 11 SLC22A11 0.0129
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0128
756 Sex hormone-binding globulin SHBG 0.0124
833 Organic cation/carnitine transporter 1 SLC22A4 0.0124
124 Histamine H2 receptor HRH2 0.0123
952 Dipeptidyl peptidase 4 DPP4 0.0123
29 Tubulin beta-1 chain TUBB1 0.0123
811 Translocator protein TSPO 0.0121
4148 Serine/threonine-protein kinase mTOR MTOR 0.0121
26 Vascular endothelial growth factor receptor 3 FLT4 0.012
1742 D-HSCDK2 CDK2deltaT 0.0119
1771 Cell division control protein 2 homolog CDK1 0.0119
3321 Cell division control protein 2 homolog CRK2 0.0119
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0119
777 Tumor necrosis factor TNF 0.0118
3939 Amine oxidase [flavin-containing] B MAOB 0.0118
70 Type-1 angiotensin II receptor AGTR1 0.0117
407 Vascular endothelial growth factor receptor 2 KDR 0.0117
629 Alpha-2B adrenergic receptor ADRA2B 0.0117
1058 Cell division protein kinase 5 CDK5 0.0116
32 Vascular endothelial growth factor receptor 1 FLT1 0.0115
818 50S ribosomal protein L10 rplJ 0.0114
161 Tubulin beta chain TUBB 0.0113
312 Tubulin beta chain TUB2 0.0113
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0113
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0112
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0111
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.011
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.011
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.011
6136 Multidrug resistance-associated protein 5 ABCC5 0.011
4120 NADPH--cytochrome P450 reductase POR 0.0108
380 Cytochrome P450 17A1 CYP17A1 0.0108
378 Alpha-2C adrenergic receptor ADRA2C 0.0107
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0107
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0106
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0106
869 Estrogen receptor beta ESR2 0.0105
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0103
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0103
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0102
228 Beta platelet-derived growth factor receptor PDGFRB 0.0101
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.01
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.01
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.01
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.01
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.01
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.01
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0099
2539 Tubulin alpha-1 chain TUBA4A 0.0098
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0097
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0096
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
436 5-hydroxytryptamine 2B receptor HTR2B 0.0093
5288 Shikimate kinase aroK 0.0092
5304 UPF0166 protein TM_0021 TM_0021 0.0092
5293 Shikimate kinase 2 aroL 0.0092
5287 Signaling protein Not Available 0.0092
2874 Nitrogenase iron protein 1 nifH1 0.0092
4346 Polynucleotide kinase pseT 0.0092
5292 Putative partitioning protein TT_C1605 0.0092
3199 Phosphopantetheine adenylyltransferase coaD 0.0092
3543 Phosphopantetheine adenylyltransferase coaD 0.0092
3567 Phosphopantetheine adenylyltransferase coaD 0.0092
5289 Phosphopantetheine adenylyltransferase coaD 0.0092
5266 Activator of hgdC 0.0092
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0092
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0092
5259 Transcriptional regulator ntrC1 0.0092
6699 Transcriptional regulator Cgl2612 0.0092
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0092
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0092
5283 D-alanine--D-alanine ligase B ddlB 0.0092
5291 Glycogen synthase 1 glgA1 0.0092
5281 Plasmid segregation protein parM parM 0.0092
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0092
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0092
5299 D-alanine--D-alanine ligase ddl 0.0092
6598 D-alanine--D-alanine ligase ddl 0.0092
5276 Chromosomal replication initiator protein dnaA dnaA 0.0092
5315 Chaperone protein htpG htpG 0.0092
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0092
5284 Large T antigen Not Available 0.0092
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0092
5264 DNA replication protein REP 0.0092
5277 Preprotein translocase subunit secA secA 0.0092
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0092
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0092
5261 Phosphoribosylformylglycinamidine synthase purL 0.0092
5308 Preprotein translocase secA 1 subunit secA1 0.0092
5285 Kinesin heavy chain KIF5B 0.0092
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0092
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0089
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0089
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0088
432 D(4) dopamine receptor DRD4 0.0087
6102 Arylamine N-acetyltransferase 2 NAT2 0.0086
6220 Aryl hydrocarbon receptor AHR 0.0086
716 5-hydroxytryptamine 7 receptor HTR7 0.0085
1010 Cytochrome P450 51A1 CYP51A1 0.0085
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0084
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
373 Transthyretin TTR 0.0083
1192 Sulfotransferase 1A1 SULT1A1 0.0083
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0083
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0082
427 Substance-P receptor TACR1 0.008
1656 CYP2B protein CYP2B 0.008
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0079
4773 Deoxycytidine kinase DCK 0.0079
477 DNA topoisomerase 4 subunit A parC 0.0078
886 DNA topoisomerase 4 subunit A parC 0.0078
6226 DNA topoisomerase 4 subunit A parC 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
1152 Glycogen phosphorylase, muscle form PYGM 0.0077
404 DNA gyrase subunit A gyrA 0.0077
6224 DNA gyrase subunit A gyrA 0.0077
340 Apoptotic protease-activating factor 1 APAF1 0.0077
4237 50S ribosomal protein L22 rplV 0.0076
2240 Cell division protein kinase 2 CDK2 0.0076
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0075
239 Coagulation factor X F10 0.0075
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0075
3470 Hypothetical protein MG245 homolog MPN_348 0.0073
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0073
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0073
6277 Heat shock cognate 71 kDa protein HSPA8 0.0073
4837 Cag-alfa cag-alfa 0.0073
4774 NTPase P4 Not Available 0.0073
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0073
5646 Galactokinase GALK1 0.0073
5265 FtsH ftsH 0.0073
4839 DNA polymerase III subunit tau dnaX 0.0073
5189 Trimethylamine dehydrogenase tmd 0.0073
5302 TrwB trwB 0.0073
4838 PMS1 protein homolog 2 PMS2 0.0073
474 Acetylcholinesterase ACHE 0.0073
2270 Dephospho-CoA kinase coaE 0.0073
4106 Guanylate kinase GUK1 0.0073
4516 Guanylate kinase gmk 0.0073
2284 Adenylate kinase adk 0.0073
2296 Adenylate kinase adk 0.0073
2311 Adenylate kinase adk 0.0073
2312 Adenylate kinase Not Available 0.0073
3175 Glutamate--cysteine ligase gshA 0.0073
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0072
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0072
3426 Glutamine synthetase glnA 0.0072
3987 Glutamine synthetase GLUL 0.0072
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0072
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0071
6020 Aldehyde oxidase AOX1 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.007
1353 DNA topoisomerase 1 TOP1 0.007
3552 DNA topoisomerase 1 topA 0.007
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.007
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.007
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0069
2683 Mono-ADP-ribosyltransferase C3 C3 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
738 Monocarboxylate transporter 1 SLC16A1 0.0068
365 Dihydrofolate reductase DHFR 0.0068
2381 Dihydrofolate reductase DFR1 0.0068
2833 Dihydrofolate reductase Not Available 0.0068
2931 Dihydrofolate reductase folA 0.0068
3544 Dihydrofolate reductase folA 0.0068
3682 Dihydrofolate reductase folA 0.0068
6642 Dihydrofolate reductase folA 0.0068
6756 Dihydrofolate reductase dfrA 0.0068
702 UMP-CMP kinase CMPK1 0.0067
723 Cytosolic phospholipase A2 PLA2G4A 0.0067
768 FK506-binding protein 1A FKBP1A 0.0067
705 Glutamate receptor 1 GRIA1 0.0067
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0067
2183 Fatty acid-binding protein, adipocyte FABP4 0.0066
5271 Focal adhesion kinase 1 PTK2 0.0065
2390 Nonsecretory ribonuclease RNASE2 0.0065
408 Riboflavin kinase RFK 0.0065
2282 Protein recA recA 0.0065
2315 Protein recA recA 0.0065
2332 Protein recA recA 0.0065
5263 Protein recA recA 0.0065
5312 Kinesin-like protein KIF1A KIF1A 0.0065
1852 Microtubule-associated protein 2 MAP2 0.0065
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0065
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0064
2922 Glycerol kinase glpK 0.0064
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0064
6085 Fatty acid-binding protein, intestinal FABP2 0.0064
165 FL cytokine receptor FLT3 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4238 50S ribosomal protein L4 rplD 0.0063
5578 50S ribosomal protein L4 rplD 0.0063
6173 50S ribosomal protein L4 rplD 0.0063
6219 50S ribosomal protein L4 rplD 0.0063
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0062
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0061
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0061
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0061
823 Fibroblast growth factor receptor 2 FGFR2 0.006
6174 50S ribosomal protein L32 rpmF 0.006
2615 Chemotaxis protein cheA cheA 0.006
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.006
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.006
2371 Pantothenate kinase coaA 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
2892 Acetylglutamate kinase argB 0.006
3550 Acetylglutamate kinase argB 0.006
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.006
3669 Ribokinase rbsK 0.006
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0059
1881 Hexokinase-1 HK1 0.0059
891 Dihydropteroate synthase folP 0.0059
5359 Dihydropteroate synthase folP 0.0059
7175 Dihydropteroate synthase sulI 0.0059
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0059
788 Creatine kinase M-type CKM 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
94 5-hydroxytryptamine 4 receptor HTR4 0.0059
319 Opioid receptor, sigma 1 OPRS1 0.0058
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0058
6014 Cytochrome P450 2A13 CYP2A13 0.0058
2091 Endoplasmin HSP90B1 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
814 Ryanodine receptor 1 RYR1 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
6138 Multidrug resistance protein 3 ABCB4 0.0057
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0057
528 5-hydroxytryptamine 1E receptor HTR1E 0.0057
2449 Tubulin alpha-3 chain TUBA1A 0.0056
2727 S-adenosylmethionine synthetase metK 0.0056
469 Annexin A1 ANXA1 0.0056
4311 tRNA TRDMT1 0.0056
4325 tRNA trmD 0.0056
4328 tRNA trmD 0.0056
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0056
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0056
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0056
4203 Histamine N-methyltransferase HNMT 0.0056
592 Carbonic anhydrase 4 CA4 0.0055
48 Pyridoxal kinase PDXK 0.0055
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0055
921 Glutamate receptor 2 GRIA2 0.0054
3932 Glutathione S-transferase A2 GSTA2 0.0054
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0054
1256 5-hydroxytryptamine 6 receptor HTR6 0.0054
2697 Uridine-cytidine kinase 2 UCK2 0.0054
207 Glutathione synthetase GSS 0.0054
5269 Glutathione synthetase gshB 0.0054
2334 Dethiobiotin synthetase bioD 0.0054
6555 Dethiobiotin synthetase bioD 0.0054
1483 Membrane copper amine oxidase AOC3 0.0054
3086 Plasmepsin-2 Not Available 0.0053
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0053
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0053
2112 Toll-like receptor 9 TLR9 0.0053
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0053
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0053
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0053
49 Endothelin B receptor EDNRB 0.0052
1618 High affinity nerve growth factor receptor NTRK1 0.0052
208 DNA-directed RNA polymerase beta' chain rpoC 0.0052
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0052
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0052
273 Apoptosis regulator Bcl-2 BCL2 0.0052
88 Retinoic acid receptor RXR-beta RXRB 0.0051
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0051
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0051
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0051
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0051
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0051
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0051
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
295 Carbonic anhydrase 1 CA1 0.005
856 Vitamin D3 receptor VDR 0.005
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.005
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.005
3947 Xanthine dehydrogenase/oxidase XDH 0.0049
6395 Myosin-14 MYH14 0.0049
1541 Metalloproteinase mmp20 0.0049
1757 Myeloperoxidase MPO 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
2251 Thymidylate kinase tmk 0.0049
2254 Thymidylate kinase DTYMK 0.0049
3522 Thymidylate kinase tmk 0.0049
1196 Complement decay-accelerating factor CD55 0.0049
24 Thymidylate synthase TMP1 0.0049
359 Thymidylate synthase TYMS 0.0049
2626 Thymidylate synthase thyA 0.0049
2729 Thymidylate synthase thyA 0.0049
5352 Thymidylate synthase THYA 0.0049
275 Arachidonate 5-lipoxygenase ALOX5 0.0049
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
163 D(1B) dopamine receptor DRD5 0.0048
1721 Glycogen synthase kinase-3 beta GSK3B 0.0047
1422 Serine/threonine-protein kinase 6 AURKA 0.0047
1178 Adenosine A2a receptor ADORA2A 0.0047
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0047
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
284 DNA-directed RNA polymerase beta chain rpoB 0.0047
5773 DNA-directed RNA polymerase beta chain rpoB 0.0047
683 Potassium transporter GK0582 0.0047
3379 Kinesin-like protein KIF11 KIF11 0.0046
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
3856 Fibroblast growth factor receptor 3 FGFR3 0.0046
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0046
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0046
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0046
4103 Proteasome subunit beta type 2 PSMB2 0.0046
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0046
4102 Proteasome subunit beta type 5 PSMB5 0.0046
4101 Proteasome subunit beta type 1 PSMB1 0.0046
54 Prothrombin F2 0.0045
4122 Histone deacetylase 2 HDAC2 0.0045
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0044
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0044
3822 Actin, alpha skeletal muscle ACTA1 0.0044
509 Thymidine kinase TK 0.0044
570 Thymidine kinase TK 0.0044
2559 Thymidine kinase TK 0.0044
3430 Thymidine kinase tdk 0.0044
3518 Thymidine kinase TK 0.0044
5301 Thymidine kinase tdk 0.0044
5771 Thymidine kinase ORF36 0.0044
7009 Thymidine kinase ORF36 0.0044
571 Melatonin receptor type 1A MTNR1A 0.0044
362 Melatonin receptor type 1B MTNR1B 0.0044
1629 Transcription factor AP-1 JUN 0.0044
1050 Bile salt sulfotransferase SULT2A1 0.0044
5923 Microtubule-associated protein tau MAPT 0.0043
5924 Microtubule-associated protein 4 MAP4 0.0043
2808 Chloramphenicol acetyltransferase 3 cat3 0.0043
904 Glutathione S-transferase P GSTP1 0.0043
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0042
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0042
162 Retinoic acid receptor gamma-1 RARG 0.0042
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
357 Carbonic anhydrase 2 CA2 0.0041
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
84 Nuclear receptor 0B1 NR0B1 0.004
6824 Tyrosine-protein kinase Lyn LYN 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.004
3809 Estrogen-related receptor gamma ESRRG 0.004
558 Solute carrier family 12 member 1 SLC12A1 0.0039
1630 Integrin beta-2 ITGB2 0.0039
1517 Beta-3 adrenergic receptor ADRB3 0.0039
976 Platelet glycoprotein IX GP9 0.0039
3601 Dihydropteroate synthase 1 folP1 0.0039
3807 Dihydropteroate synthase 1 folP1 0.0039
3808 Dihydropteroate synthase 2 folP2 0.0039
2417 Chloramphenicol acetyltransferase cat 0.0039
3278 Chloramphenicol acetyltransferase cat 0.0039
16 Adenosine A1 receptor ADORA1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2810 Dr hemagglutinin structural subunit draA 0.0039
5682 Ribonuclease pancreatic RNASE1 0.0038
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0038
6043 Putative G-protein coupled receptor 44 GPR44 0.0038
85 Growth hormone receptor GHR 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0037
153 Dopamine beta-hydroxylase DBH 0.0037
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0037
6432 Transporter snf 0.0037
3913 Glutamic acid decarboxylase GAD65 0.0037
4192 DNA topoisomerase 2-beta TOP2B 0.0037
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0036
518 Peroxidase/catalase T katG 0.0036
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
581 Cytochrome P450 2R1 CYP2R1 0.0035
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0035
174 Sigma 1-type opioid receptor SIGMAR1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
936 Ephrin type-A receptor 2 EPHA2 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0034
5880 Thrombopoietin receptor MPL 0.0033
780 Retinoic acid receptor RXR-gamma RXRG 0.0033
33 Cystine/glutamate transporter SLC7A11 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
6044 Serum paraoxonase/lactonase 3 PON3 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0031
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0031
1648 Elastin ELN 0.0031
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0031
735 Alanine aminotransferase 1 GPT 0.0031
3904 Alanine aminotransferase 2 GPT2 0.0031
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
634 Squalene monooxygenase SQLE 0.003
7196 Squalene monooxygenase ERG1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
106 Cannabinoid receptor 2 CNR2 0.003
3868 Calcineurin subunit B isoform 2 PPP3R2 0.003
572 Integrin alpha-L ITGAL 0.003
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
2216 Fibroblast growth factor receptor 4 FGFR4 0.0029
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0029
6149 Solute carrier family 22 member 10 SLC22A10 0.0029
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
1525 Heparin-binding growth factor 2 FGF2 0.0028
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0028
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
4217 Telomerase reverse transcriptase TERT 0.0028
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0027
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
511 5-hydroxytryptamine 1F receptor HTR1F 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0027
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0026
6048 Troponin C, skeletal muscle TNNC2 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0026
5934 Cytochrome P450 26A1 CYP26A1 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
605 Fumarate reductase flavoprotein subunit frdA 0.0026
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0026
3673 Fumarate reductase flavoprotein subunit fccA 0.0026
4912 Fumarate reductase flavoprotein subunit ifcA 0.0026
6549 Fumarate reductase flavoprotein subunit frdA 0.0026
3810 Catechol O-methyltransferase COMT 0.0026
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
7 Nitric oxide synthase, inducible NOS2 0.0025
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0024
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0024
6146 High affinity copper uptake protein 1 SLC31A1 0.0024
267 Plasminogen activator inhibitor 1 SERPINE1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
1992 Vitamin D-binding protein GC 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
65 Matrix metalloproteinase-9 Not Available 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
908 Glutathione S-transferase theta-1 GSTT1 0.0023
5816 Cadherin-5 CDH5 0.0023
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0023
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0023
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0023
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0022
489 Monocarboxylate transporter 2 SLC16A7 0.0022
5798 Mitogen-activated protein kinase 11 MAPK11 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
6221 Steroid hormone receptor ERR1 ESRRA 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0022
1864 RET proto-oncogene RET 0.0022
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0021
298 Renin REN 0.0021
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0021
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0021
6506 Stathmin-4 STMN4 0.0021
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0021
1039 Histone deacetylase 9 HDAC9 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
719 Retinoic acid receptor responder protein 1 RARRES1 0.002
770 Retinoic acid-induced protein 3 GPRC5A 0.002
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.002
1063 Signal transducer and activator of transcription 5B STAT5B 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
2021 Thrombomodulin THBD 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
6218 Pannexin-1 PANX1 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0018
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0018
1253 Interferon gamma IFNG 0.0018
563 Thyroid peroxidase TPO 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
2981 Phospholipase A2, membrane associated PLA2G2A 0.0018
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
569 Retinal dehydrogenase 2 ALDH1A2 0.0018
482 Glycine receptor subunit alpha-1 GLRA1 0.0018
3937 Fatty-acid amide hydrolase FAAH 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
3957 Adenosine deaminase ADA 0.0017
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
611 Retinal dehydrogenase 1 ALDH1A1 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
164 Histamine H4 receptor HRH4 0.0016
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0016
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0016
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
3233 Bile acid receptor NR1H4 0.0015
6755 Poliovirus receptor PVR 0.0015
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
6677 Myelin P2 protein PMP2 0.0015
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
2207 Rhodopsin RHO 0.0014
1275 Estrogen sulfotransferase SULT1E1 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
444 Alcohol dehydrogenase 1B ADH1B 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0013
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0013
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0013
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0013
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0013
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
1360 Sphingomyelin phosphodiesterase SMPD1 0.0012
6151 Monocarboxylate transporter 10 SLC16A10 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
251 Alcohol dehydrogenase 1A ADH1A 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
291 Nitric-oxide synthase, endothelial NOS3 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
517 Alcohol dehydrogenase 1C ADH1C 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
820 Glycine receptor subunit alpha-2 GLRA2 0.0011
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
4226 Uridine phosphorylase 2 UPP2 0.0009
3830 Calreticulin CALR 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
4225 Uridine phosphorylase 1 UPP1 0.0009
2132 Protein S100-B S100B 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
413 Amidophosphoribosyltransferase PPAT 0.0008
2515 Amidophosphoribosyltransferase purF 0.0008
3714 Amidophosphoribosyltransferase purF 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2298 Cytochrome P450-cam camC 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0007
130 Prostacyclin synthase PTGIS 0.0007
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
125 DNA polymerase beta POLB 0.0007
3639 Thymidine phosphorylase deoA 0.0007
3936 Thymidine phosphorylase TYMP 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
3221 Cytochrome c4 cc4 0.0006
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4943 Cytochrome c6 petJ 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4961 Hemophore HasA hasA 0.0003
4909 CooA protein cooA 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
5000 HemO hemO 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4910 Cytoglobin CYGB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4972 P450cin cinA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
4920 Peroxidase/catalase katG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
4948 Cytochrome c-553 Not Available 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
6021 Adenosine kinase ADK 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
↑