DT-Web: DB06209

Identification

Name

Prasugrel

Accession Number

DB06209

Type

small molecule

Description

Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversibly binds to P2Y12 type ADP receptors on platelets thus preventing activation of the GPIIb/IIIa receptor complex. As a result, inhibition of ADP-mediated platelet activation and aggregation occurs. Prasugrel was developed by Daiichi Sankyo Co. and is currently marketed in the United States and Canada in cooperation with Eli Lilly and Company for acute coronary syndromes planned for percutaneous coronary intervention (PCI). FDA approved in 2009.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antiplatelet Agents

Molecular Weight

373.441

Groups

approved

Monoisotopic Weight

373.114792406

Pharmacology

Indication

Indicated in combination with acetylsalicylic acid (ASA) to prevent atherothrombotic events in patients with acute coronary syndrome (ACS) who are to be managed with percutaneous coronary intervention (PCI). May be used in patients with unstable angina (UA), non-ST elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarction (STEMI) who are to be managed with PCI. Prasugrel is not recommended in patients 75 years of age or greater, those that weigh<60kg, and patients with a history of stroke or transient ischemic attack due to increased risk of fatal and intracranial bleeding.

Mechanism of action

Prasugrel is an thienopyridine and a prodrug which inhibits ADP receptors by irreversibly acting on the P2Y12 receptor on platelets. The active metabolite of prasugrel prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. Prasugrel is proposed to have a similar mechanism of action to clopidogrel.

Absorption

79% or greater of the dose is absorbed after oral administration. Absorption and metabolism occur rapidly and peak plasma concentrations (C_max) are reached approximately 30 minutes following oral administration. Administration with a high fat, high calorie meal did not affect the AUC of the active metabolite in healthy individuals, but the C_max was decreased by ~49% and the T_max was increased to 0.5 to 1.5 hours. Prasugrel may be administered with or without food.

Protein binding

Approximately 98% of the active metabolite was bound to human serum albumin in a 4% buffered solution. The major inactive metabolites are also highly bound to human plasma proteins.

Biotransformation

Prasugrel is not detected in plasma following oral administration. It is rapidly hydrolyzed in the intestine to thiolactone by human carboxylesterase (hCE) 2. This intermediate is further metabolized to its active metabolite, R-138727, in a single step by cytochrome P450 enzymes in the liver (primarily CYP3A4 and CYP2B6 and to a lesser extent by CYP2C9 and CYP2C19). The active metabolite is further metabolized by S-methylation or cysteine conjugation to two inactive metabolites. Unlike clopidogrel, transformation of prasugrel to its active metabolite does not appear to be affected by cytochrome P450 polymorphisms.

Route of elimination

Approximately 68% of the orally administered dose is excreted in urine and 27% in the feces, as inactive metabolites. The active metabolite is not expected to be removed by dialysis.

Toxicity

LD50 (rat) 1,000 - 2,000 mg/kg; LD50 (rabbit) > 1,000 mg/kg

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Ibuprofen	Coadministration with NSAIDS used chronically may increase the risk of bleeding.
Ketoconazole	Ketoconazole is a potent inhibitor of CYP3A4 which decreases the Cmax of prasugrel due to a reduction of prasugrel bioactivation. However, there was no reduction of inhibition of platelet aggregation.
Lansoprazole	Lansoprazole is a CYP2C19 substrate which decreases AUC and Cmax of prasugrel. Despite these decreases, there was no significant reduction of inhibition of platelet aggregation.
Ritonavir	Ritonavir is a inhibitor of CYP3A4, thus blocking the bioactivation of prasugrel. As a result, a reduction in prasugrel efficiency may be observed in patients.
Warfarin	Coadministration with warfarin may increase the risk of bleeding.

Food Interactions

Despite being a CYP3A4 inducer, grapefruit juice does not affect the pharmacokinetics of prasugrel

P2Y purinoceptor 12
Name	P2Y purinoceptor 12
Gene Name	P2RY12
Pharmacological action	yes
Actions	antagonist
References	Dovlatova NL, Jakubowski JA, Sugidachi A, Heptinstall S: The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function. J Thromb Haemost. 2008 Jul;6(7):1153-9. Epub 2008 Jul 1. - Pubmed
DTHybrid score	0.3357

Cocaine esterase
Name	Cocaine esterase
Gene Name	Not Available
Actions	substrate
References	Angiolillo DJ: The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012 Nov 12;72(16):2087-116. doi: 10.2165/11640880-000000000-00000. - Pubmed
DTHybrid score	Not Available
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Angiolillo DJ: The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012 Nov 12;72(16):2087-116. doi: 10.2165/11640880-000000000-00000. - Pubmed
DTHybrid score	0.5381
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Angiolillo DJ: The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012 Nov 12;72(16):2087-116. doi: 10.2165/11640880-000000000-00000. - Pubmed
DTHybrid score	0.3068
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Angiolillo DJ: The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012 Nov 12;72(16):2087-116. doi: 10.2165/11640880-000000000-00000. - Pubmed
DTHybrid score	0.4674
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Angiolillo DJ: The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012 Nov 12;72(16):2087-116. doi: 10.2165/11640880-000000000-00000. - Pubmed
DTHybrid score	0.3769

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.2279
4924	Cytochrome P450 2C8	CYP2C8	0.2147
4200	Cytochrome P450 1A2	CYP1A2	0.2075
1588	Multidrug resistance protein 1	ABCB1	0.2071
4118	Cytochrome P450 3A5	CYP3A5	0.1557
6013	Cytochrome P450 2E1	CYP2E1	0.1245
527	Prostacyclin receptor	PTGIR	0.1081
6107	Cytochrome P450 3A7	CYP3A7	0.0999
20	Prostaglandin G/H synthase 1	PTGS1	0.0877
5718	Cytochrome P450 2A6	CYP2A6	0.0802
6024	Cytochrome P450 1A1	CYP1A1	0.0763
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0604
130	Prostacyclin synthase	PTGIS	0.0603
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0597
1729	Solute carrier family 22 member 6	SLC22A6	0.0515
6106	Cytochrome P450 2C18	CYP2C18	0.0508
290	Prostaglandin G/H synthase 2	PTGS2	0.0508
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0497
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0466
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0435
492	Histamine H1 receptor	HRH1	0.0433
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0408
824	Sodium-dependent serotonin transporter	SLC6A4	0.0391
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0374
891	Dihydropteroate synthase	folP	0.0365
5359	Dihydropteroate synthase	folP	0.0365
7175	Dihydropteroate synthase	sulI	0.0365
862	Multidrug resistance-associated protein 1	ABCC1	0.0359
3811	Cytochrome P450 19A1	CYP19A1	0.0359
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0344
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0337
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0337
6142	Solute carrier family 22 member 8	SLC22A8	0.0323
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.032
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0317
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0314
6145	Solute carrier family 22 member 1	SLC22A1	0.0302
136	Estrogen receptor	ESR1	0.028
4604	Liver carboxylesterase 1	CES1	0.0278
556	Alpha-1A adrenergic receptor	ADRA1A	0.027
731	HIV-1 protease	HIV-1 protease	0.0268
831	D(2) dopamine receptor	DRD2	0.0262
2164	Multidrug resistance-associated protein 4	ABCC4	0.0246
260	Cytochrome P450 51	ERG11	0.0242
761	Cytochrome P450 51	ERG11	0.0242
3163	Cytochrome P450 51	cyp51	0.0242
1898	Cytochrome P450 1B1	CYP1B1	0.0238
6144	Solute carrier family 22 member 2	SLC22A2	0.023
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.023
713	Sodium-dependent dopamine transporter	SLC6A3	0.0226
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0225
6143	Solute carrier family 22 member 7	SLC22A7	0.0223
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0218
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0217
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0214
1024	Solute carrier family 22 member 11	SLC22A11	0.0214
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0213
1757	Myeloperoxidase	MPO	0.0206
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0205
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0204
776	Bile salt export pump	ABCB11	0.0203
847	Mu-type opioid receptor	OPRM1	0.0203
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.02
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.02
871	Glucocorticoid receptor	NR3C1	0.0197
23	D(1A) dopamine receptor	DRD1	0.0195
632	Alpha-1B adrenergic receptor	ADRA1B	0.0191
320	5-hydroxytryptamine 1A receptor	HTR1A	0.019
318	Alpha-2A adrenergic receptor	ADRA2A	0.0187
468	Cytochrome P450 4A11	CYP4A11	0.0185
118	Organic cation/carnitine transporter 2	SLC22A5	0.0181
617	Muscarinic acetylcholine receptor M2	CHRM2	0.018
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0179
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0177
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0175
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0173
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0173
146	Androgen receptor	AR	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0168
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0168
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0168
696	Kappa-type opioid receptor	OPRK1	0.0165
467	Delta-type opioid receptor	OPRD1	0.0165
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0158
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0155
3941	Amine oxidase [flavin-containing] A	MAOA	0.0155
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0155
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0154
482	Glycine receptor subunit alpha-1	GLRA1	0.0154
465	Calmodulin	CALM1	0.0153
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0153
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.015
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0148
70	Type-1 angiotensin II receptor	AGTR1	0.0147
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0146
756	Sex hormone-binding globulin	SHBG	0.0144
766	Beta-2 adrenergic receptor	ADRB2	0.0143
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
3923	Cholinesterase	BCHE	0.0142
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0141
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0139
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0139
6031	Cytochrome P450 3A43	CYP3A43	0.0136
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0134
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0133
705	Glutamate receptor 1	GRIA1	0.0131
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0129
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0129
3939	Amine oxidase [flavin-containing] B	MAOB	0.0127
6147	Solute carrier family 22 member 3	SLC22A3	0.0127
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0126
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0126
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0126
789	Alpha-1D adrenergic receptor	ADRA1D	0.0123
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0123
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0123
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0123
811	Translocator protein	TSPO	0.0122
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0121
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0119
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0116
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0116
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0114
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0112
844	Epidermal growth factor receptor	EGFR	0.0111
6136	Multidrug resistance-associated protein 5	ABCC5	0.0109
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0109
183	Vascular endothelial growth factor A	VEGFA	0.0108
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0107
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0106
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0106
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0106
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0106
614	Progesterone receptor	PGR	0.0105
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0105
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0105
818	50S ribosomal protein L10	rplJ	0.0104
6182	Cytochrome P450 2J2	CYP2J2	0.0103
6085	Fatty acid-binding protein, intestinal	FABP2	0.0103
1656	CYP2B protein	CYP2B	0.0102
4120	NADPH--cytochrome P450 reductase	POR	0.0102
6137	Multidrug resistance-associated protein 6	ABCC6	0.0101
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0101
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.01
2211	Fatty acid-binding protein, heart	FABP3	0.0098
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0097
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0097
49	Endothelin B receptor	EDNRB	0.0096
817	DNA topoisomerase 2-alpha	TOP2A	0.0096
6141	Sodium/bile acid cotransporter	SLC10A1	0.0095
373	Transthyretin	TTR	0.0095
566	Serotransferrin	TF	0.0094
6220	Aryl hydrocarbon receptor	AHR	0.0094
833	Organic cation/carnitine transporter 1	SLC22A4	0.0093
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0093
193	Beta-1 adrenergic receptor	ADRB1	0.0092
578	Endothelin-1 receptor	EDNRA	0.009
592	Carbonic anhydrase 4	CA4	0.009
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.009
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.009
638	D(3) dopamine receptor	DRD3	0.0089
869	Estrogen receptor beta	ESR2	0.0089
504	Mast/stem cell growth factor receptor	KIT	0.0088
174	Sigma 1-type opioid receptor	SIGMAR1	0.0087
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0087
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0086
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0086
6102	Arylamine N-acetyltransferase 2	NAT2	0.0085
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0085
124	Histamine H2 receptor	HRH2	0.0084
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0084
629	Alpha-2B adrenergic receptor	ADRA2B	0.0082
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0082
232	Corticosteroid-binding globulin	SERPINA6	0.008
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.008
295	Carbonic anhydrase 1	CA1	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
427	Substance-P receptor	TACR1	0.0079
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0079
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0079
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0079
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
357	Carbonic anhydrase 2	CA2	0.0077
738	Monocarboxylate transporter 1	SLC16A1	0.0076
161	Tubulin beta chain	TUBB	0.0076
312	Tubulin beta chain	TUB2	0.0076
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0076
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0076
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0075
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0075
407	Vascular endothelial growth factor receptor 2	KDR	0.0075
6014	Cytochrome P450 2A13	CYP2A13	0.0075
558	Solute carrier family 12 member 1	SLC12A1	0.0073
6148	Multidrug resistance-associated protein 7	ABCC10	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
380	Cytochrome P450 17A1	CYP17A1	0.0072
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0072
1010	Cytochrome P450 51A1	CYP51A1	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
716	5-hydroxytryptamine 7 receptor	HTR7	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.007
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.007
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.007
921	Glutamate receptor 2	GRIA2	0.0069
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0068
777	Tumor necrosis factor	TNF	0.0068
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0068
3932	Glutathione S-transferase A2	GSTA2	0.0068
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0067
29	Tubulin beta-1 chain	TUBB1	0.0066
36	Insulin receptor	INSR	0.0066
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0066
378	Alpha-2C adrenergic receptor	ADRA2C	0.0066
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0066
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0065
26	Vascular endothelial growth factor receptor 3	FLT4	0.0063
6043	Putative G-protein coupled receptor 44	GPR44	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
133	Dihydropterate synthase	sulI	0.0063
459	Retinoic acid receptor RXR-alpha	RXRA	0.0062
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0061
432	D(4) dopamine receptor	DRD4	0.0061
32	Vascular endothelial growth factor receptor 1	FLT1	0.0061
6020	Aldehyde oxidase	AOX1	0.006
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.006
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
1618	High affinity nerve growth factor receptor	NTRK1	0.0058
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0058
68	Cannabinoid receptor 1	CNR1	0.0058
780	Retinoic acid receptor RXR-gamma	RXRG	0.0058
856	Vitamin D3 receptor	VDR	0.0058
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0058
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0058
365	Dihydrofolate reductase	DHFR	0.0057
2381	Dihydrofolate reductase	DFR1	0.0057
2833	Dihydrofolate reductase	Not Available	0.0057
2931	Dihydrofolate reductase	folA	0.0057
3544	Dihydrofolate reductase	folA	0.0057
3682	Dihydrofolate reductase	folA	0.0057
6642	Dihydrofolate reductase	folA	0.0057
6756	Dihydrofolate reductase	dfrA	0.0057
275	Arachidonate 5-lipoxygenase	ALOX5	0.0056
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0055
3810	Catechol O-methyltransferase	COMT	0.0055
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0054
1992	Vitamin D-binding protein	GC	0.0054
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0054
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0054
88	Retinoic acid receptor RXR-beta	RXRB	0.0053
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0053
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0052
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0052
6126	Carbonic anhydrase 7	CA7	0.0052
94	5-hydroxytryptamine 4 receptor	HTR4	0.0051
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0051
952	Dipeptidyl peptidase 4	DPP4	0.0051
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
6432	Transporter	snf	0.0049
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0048
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
563	Thyroid peroxidase	TPO	0.0047
581	Cytochrome P450 2R1	CYP2R1	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
5787	Angiopoietin-1 receptor	TEK	0.0046
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0045
768	FK506-binding protein 1A	FKBP1A	0.0045
24	Thymidylate synthase	TMP1	0.0045
359	Thymidylate synthase	TYMS	0.0045
2626	Thymidylate synthase	thyA	0.0045
2729	Thymidylate synthase	thyA	0.0045
5352	Thymidylate synthase	THYA	0.0045
474	Acetylcholinesterase	ACHE	0.0045
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0045
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0044
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
6138	Multidrug resistance protein 3	ABCB4	0.0044
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0044
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0043
284	DNA-directed RNA polymerase beta chain	rpoB	0.0043
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0043
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0043
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0043
2539	Tubulin alpha-1 chain	TUBA4A	0.0043
1050	Bile salt sulfotransferase	SULT2A1	0.0042
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0042
6103	Arylamine N-acetyltransferase 1	NAT1	0.0042
3947	Xanthine dehydrogenase/oxidase	XDH	0.0042
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0042
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0041
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0041
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0041
6149	Solute carrier family 22 member 10	SLC22A10	0.0041
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0041
823	Fibroblast growth factor receptor 2	FGFR2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
163	D(1B) dopamine receptor	DRD5	0.004
5934	Cytochrome P450 26A1	CYP26A1	0.004
814	Ryanodine receptor 1	RYR1	0.0039
1541	Metalloproteinase	mmp20	0.0039
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
1275	Estrogen sulfotransferase	SULT1E1	0.0038
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0038
85	Growth hormone receptor	GHR	0.0038
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0037
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0037
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0037
3426	Glutamine synthetase	glnA	0.0037
3987	Glutamine synthetase	GLUL	0.0037
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0037
54	Prothrombin	F2	0.0037
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0037
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0037
904	Glutathione S-transferase P	GSTP1	0.0036
84	Nuclear receptor 0B1	NR0B1	0.0036
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0036
594	Thyroxine-binding globulin	SERPINA7	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
4237	50S ribosomal protein L22	rplV	0.0035
518	Peroxidase/catalase T	katG	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
1517	Beta-3 adrenergic receptor	ADRB3	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0035
153	Dopamine beta-hydroxylase	DBH	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0034
319	Opioid receptor, sigma 1	OPRS1	0.0034
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0034
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0034
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0034
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0034
737	Mineralocorticoid receptor	NR3C2	0.0034
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0033
758	Thyroid hormone receptor alpha	THRA	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
1630	Integrin beta-2	ITGB2	0.0032
1353	DNA topoisomerase 1	TOP1	0.0032
3552	DNA topoisomerase 1	topA	0.0032
65	Matrix metalloproteinase-9	Not Available	0.0032
6677	Myelin P2 protein	PMP2	0.0032
1867	Major prion protein	PRNP	0.0032
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0032
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0032
3937	Fatty-acid amide hydrolase	FAAH	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
7	Nitric oxide synthase, inducible	NOS2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
4203	Histamine N-methyltransferase	HNMT	0.0031
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
5300	Antigen peptide transporter 1	TAP1	0.0031
4217	Telomerase reverse transcriptase	TERT	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
106	Cannabinoid receptor 2	CNR2	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
346	Thyroid hormone receptor beta-1	THRB	0.003
6174	50S ribosomal protein L32	rpmF	0.003
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.003
1196	Complement decay-accelerating factor	CD55	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
251	Alcohol dehydrogenase 1A	ADH1A	0.0029
6146	High affinity copper uptake protein 1	SLC31A1	0.0029
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0029
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0029
6033	High affinity interleukin-8 receptor A	CXCR1	0.0029
4122	Histone deacetylase 2	HDAC2	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
162	Retinoic acid receptor gamma-1	RARG	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0028
3809	Estrogen-related receptor gamma	ESRRG	0.0028
131	Synaptic vesicular amine transporter	SLC18A2	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1525	Heparin-binding growth factor 2	FGF2	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
2207	Rhodopsin	RHO	0.0027
820	Glycine receptor subunit alpha-2	GLRA2	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
3639	Thymidine phosphorylase	deoA	0.0027
3936	Thymidine phosphorylase	TYMP	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0027
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0027
634	Squalene monooxygenase	SQLE	0.0027
7196	Squalene monooxygenase	ERG1	0.0027
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
4210	Toll-like receptor 4	TLR4	0.0026
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0026
1192	Sulfotransferase 1A1	SULT1A1	0.0026
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0026
444	Alcohol dehydrogenase 1B	ADH1B	0.0026
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0026
273	Apoptosis regulator Bcl-2	BCL2	0.0026
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0026
2808	Chloramphenicol acetyltransferase 3	cat3	0.0026
165	FL cytokine receptor	FLT3	0.0025
33	Cystine/glutamate transporter	SLC7A11	0.0025
239	Coagulation factor X	F10	0.0025
1629	Transcription factor AP-1	JUN	0.0025
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0025
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0025
1268	Neuropeptide S receptor	NPSR1	0.0025
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0025
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0025
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0025
5798	Mitogen-activated protein kinase 11	MAPK11	0.0025
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0025
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0025
1648	Elastin	ELN	0.0024
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
267	Plasminogen activator inhibitor 1	SERPINE1	0.0024
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2320	Thymidine kinase, cytosolic	TK1	0.0024
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3808	Dihydropteroate synthase 2	folP2	0.0023
3601	Dihydropteroate synthase 1	folP1	0.0023
3807	Dihydropteroate synthase 1	folP1	0.0023
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0023
2417	Chloramphenicol acetyltransferase	cat	0.0023
3278	Chloramphenicol acetyltransferase	cat	0.0023
1864	RET proto-oncogene	RET	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0023
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0023
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0023
2810	Dr hemagglutinin structural subunit	draA	0.0023
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0023
6073	Potassium channel subfamily K member 9	KCNK9	0.0023
6072	Potassium channel subfamily K member 3	KCNK3	0.0023
1291	cAMP response element-binding protein	CREB1	0.0023
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0023
1262	Corticotropin-lipotropin	POMC	0.0023
517	Alcohol dehydrogenase 1C	ADH1C	0.0022
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0022
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0022
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0022
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0022
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0022
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0022
936	Ephrin type-A receptor 2	EPHA2	0.0022
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
2021	Thrombomodulin	THBD	0.0022
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0022
16	Adenosine A1 receptor	ADORA1	0.0022
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0022
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0022
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0022
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
469	Annexin A1	ANXA1	0.0022
6221	Steroid hormone receptor ERR1	ESRRA	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
199	Monocarboxylate transporter 8	SLC16A2	0.0022
2232	Interleukin-5	IL5	0.0022
164	Histamine H4 receptor	HRH4	0.0021
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0021
707	72 kDa type IV collagenase	MMP2	0.0021
6218	Pannexin-1	PANX1	0.0021
1178	Adenosine A2a receptor	ADORA2A	0.0021
1039	Histone deacetylase 9	HDAC9	0.0021
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0021
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
244	Angiotensin-converting enzyme	ACE	0.0021
1852	Microtubule-associated protein 2	MAP2	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
719	Retinoic acid receptor responder protein 1	RARRES1	0.002
770	Retinoic acid-induced protein 3	GPRC5A	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
6501	Fatty acid-binding protein, liver	FABP1	0.002
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.002
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.002
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.002
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
4311	tRNA	TRDMT1	0.002
4325	tRNA	trmD	0.002
4328	tRNA	trmD	0.002
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
291	Nitric-oxide synthase, endothelial	NOS3	0.002
976	Platelet glycoprotein IX	GP9	0.0019
4103	Proteasome subunit beta type 2	PSMB2	0.0019
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0019
4102	Proteasome subunit beta type 5	PSMB5	0.0019
4101	Proteasome subunit beta type 1	PSMB1	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
4226	Uridine phosphorylase 2	UPP2	0.0018
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0018
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
1253	Interferon gamma	IFNG	0.0018
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
683	Potassium transporter	GK0582	0.0018
569	Retinal dehydrogenase 2	ALDH1A2	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
4225	Uridine phosphorylase 1	UPP1	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
896	Glutathione S-transferase Mu 1	GSTM1	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
4773	Deoxycytidine kinase	DCK	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
3830	Calreticulin	CALR	0.0017
611	Retinal dehydrogenase 1	ALDH1A1	0.0017
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
6042	Prostaglandin reductase 2	PTGR2	0.0016
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0016
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
413	Amidophosphoribosyltransferase	PPAT	0.0016
2515	Amidophosphoribosyltransferase	purF	0.0016
3714	Amidophosphoribosyltransferase	purF	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0016
6044	Serum paraoxonase/lactonase 3	PON3	0.0016
173	Toll-like receptor 7	TLR7	0.0016
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0016
751	Potassium channel subfamily K member 6	KCNK6	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
3233	Bile acid receptor	NR1H4	0.0015
1792	Tissue-type plasminogen activator	PLAT	0.0015
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0015
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0015
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0015
572	Integrin alpha-L	ITGAL	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
172	Potassium channel subfamily K member 1	KCNK1	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
605	Fumarate reductase flavoprotein subunit	frdA	0.0014
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0014
3673	Fumarate reductase flavoprotein subunit	fccA	0.0014
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0014
6549	Fumarate reductase flavoprotein subunit	frdA	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
2300	Lysozyme	E	0.0014
3633	Lysozyme	R	0.0014
5597	Lysozyme	17	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
489	Monocarboxylate transporter 2	SLC16A7	0.0014
908	Glutathione S-transferase theta-1	GSTT1	0.0013
6151	Monocarboxylate transporter 10	SLC16A10	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
6459	Glycodelin	PAEP	0.0013
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0013
1313	Lactoylglutathione lyase	GLO1	0.0013
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
822	Aldose reductase	AKR1B1	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
5924	Microtubule-associated protein 4	MAP4	0.0012
5923	Microtubule-associated protein tau	MAPT	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
6163	Copper-transporting ATPase 2	ATP7B	0.0012
6165	Copper-transporting ATPase 1	ATP7A	0.0012
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0011
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
1374	Natriuretic peptides B	NPPB	0.0011
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0011
1827	Gap junction alpha-1 protein	GJA1	0.0011
1908	Vascular cell adhesion protein 1	VCAM1	0.0011
4386	Hemoglobin-like protein HbN	glbN	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
2298	Cytochrome P450-cam	camC	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
3221	Cytochrome c4	cc4	0.001
76	Nitric-oxide synthase, brain	NOS1	0.001
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0009
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0009
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
6168	Solute carrier family 22 member 16	SLC22A16	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
4954	Soluble cytochrome b558	Not Available	0.0009
4943	Cytochrome c6	petJ	0.0009
4916	Cyanoglobin	glbN	0.0009
4925	Cytochrome c-type protein SHP	shp	0.0009
4947	Bacterial hemoglobin	vhb	0.0009
4994	Hemoglobin-like protein HbO	glbO	0.0009
4915	Cytochrome c-550	psbV	0.0009
4959	Cytochrome c-550	psbV	0.0009
5216	Cytochrome c-550	psbV	0.0009
4934	Cytochrome c-551	nirM	0.0009
5218	Cytochrome c-551	nirM	0.0009
4984	Neuroglobin	NGB	0.0009
4975	Cytochrome c-556	RPA3973	0.0009
5000	HemO	hemO	0.0009
4981	Iron-starvation protein PigA	pigA	0.0009
4905	Cytochrome c2	Not Available	0.0009
4939	Cytochrome c2	cycA	0.0009
4964	Cytochrome c2	cycA	0.0009
4979	Cytochrome c2	cycA	0.0009
6673	Cytochrome c2	cycA	0.0009
4942	Diheme cytochrome c napB	napB	0.0009
4910	Cytoglobin	CYGB	0.0009
3116	Bacterioferritin	bfr	0.0009
4906	Bacterioferritin	bfr	0.0009
4965	Bacterioferritin	bfr	0.0009
4936	Cytochrome c2 iso-2	Not Available	0.0009
4998	Hemoglobin-like protein yjbI	yjbI	0.0009
4935	Cytochrome c-554	cycA1	0.0009
4909	CooA protein	cooA	0.0009
4907	Cytochrome c-L	moxG	0.0009
6865	Cytochrome c-L	moxG	0.0009
644	Heme oxygenase 2	HMOX2	0.0009
4982	Heme oxygenase 2	pbsA2	0.0009
4961	Hemophore HasA	hasA	0.0009
4971	Nonaheme cytochrome c	hmcA	0.0009
4904	Cytochrome c family protein	GSU1996	0.0009
4976	Apocytochrome f	petA	0.0009
6407	Apocytochrome f	petA	0.0009
4931	Cytochrome P450 167A1	CYP167A1	0.0009
4903	Methyl-accepting chemotaxis protein	Tar4	0.0009
4937	Cytochrome oxidase subunit II	rcoxA	0.0009
4764	Cytochrome P450 165C4	CYP165C4	0.0009
4972	P450cin	cinA	0.0009
4960	Putative cytochrome P450-family protein	SCO7417	0.0009
4989	Cytochrome c551 peroxidase	ccp	0.0009
5222	Cytochrome c551 peroxidase	ccpA	0.0009
4999	Cytochrome P450 165B3	CYP165B3	0.0009
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0009
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0009
4922	Cytochrome c, putative	SO_4144	0.0009
4993	Hydroxylamine oxidoreductase	hao1	0.0009
4952	Catalase/peroxidase	katA	0.0009
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0009
3093	Catalase HPII	katE	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
1507	Cytochrome c	CYCS	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
5818	Folate receptor alpha	FOLR1	0.0007
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
4920	Peroxidase/catalase	katG	0.0007
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
293	Gamma-glutamyl hydrolase	GGH	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
3957	Adenosine deaminase	ADA	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
4192	DNA topoisomerase 2-beta	TOP2B	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
1650	Heme carrier protein 1	SLC46A1	0.0006
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0006
3411	Cytochrome P450 121	cyp121	0.0006
3670	Soluble cytochrome b562 precursor	cybC	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
3291	Cytochrome c-552	cycA	0.0006
4927	Cytochrome c-552	nrfA	0.0006
4938	Cytochrome c-552	cycA	0.0006
4953	Cytochrome c-552	nrfA	0.0006
5217	Cytochrome c-552	cycM	0.0006
2617	Nitric oxide synthase oxygenase	nos	0.0006
2701	Nitric oxide synthase oxygenase	nos	0.0006
3102	Flavohemoprotein	hmp	0.0006
4969	Flavohemoprotein	hmp	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
4608	Putative cytochrome P450	SCO1207	0.0005
4963	Putative cytochrome P450	SCO2884	0.0005
6254	Putative cytochrome P450	SCO6998	0.0005
5961	Insulin	INS	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
6755	Poliovirus receptor	PVR	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
2297	Genome polyprotein	Not Available	0.0004
2322	Genome polyprotein	Not Available	0.0004
2694	Genome polyprotein	Not Available	0.0004
2719	Genome polyprotein	Not Available	0.0004
2860	Genome polyprotein	Not Available	0.0004
2928	Genome polyprotein	Not Available	0.0004
3160	Genome polyprotein	Not Available	0.0004
3260	Genome polyprotein	Not Available	0.0004
4783	Genome polyprotein	Not Available	0.0004
5726	Genome polyprotein	Not Available	0.0004
5779	Genome polyprotein	Not Available	0.0004
5867	Genome polyprotein	Not Available	0.0004
6253	Genome polyprotein	Not Available	0.0004
6301	Genome polyprotein	Not Available	0.0004
6380	Genome polyprotein	Not Available	0.0004
6381	Genome polyprotein	Not Available	0.0004
6437	Genome polyprotein	Not Available	0.0004
6520	Genome polyprotein	Not Available	0.0004
6521	Genome polyprotein	Not Available	0.0004
6652	Genome polyprotein	Not Available	0.0004
6734	Genome polyprotein	Not Available	0.0004
6735	Genome polyprotein	Not Available	0.0004
6736	Genome polyprotein	Not Available	0.0004
6737	Genome polyprotein	Not Available	0.0004
6738	Genome polyprotein	Not Available	0.0004
6739	Genome polyprotein	Not Available	0.0004
6744	Genome polyprotein	Not Available	0.0004
6748	Genome polyprotein	Not Available	0.0004
6894	Genome polyprotein	Not Available	0.0004
6898	Genome polyprotein	Not Available	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6228	Nuclear receptor coactivator 1	NCOA1	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB06209 - Prasugrel

Targets

Enzymes

Carriers

Predictions