DT-Web: DB00358

Identification

Name

Mefloquine

Accession Number

DB00358 (APRD00300)

Type

small molecule

Description

A phospholipid-interacting antimalarial drug (antimalarials). It is very effective against plasmodium falciparum with very few side effects. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antimalarials

Molecular Weight

378.3122

Groups

approved

Monoisotopic Weight

378.116682374

Pharmacology

Indication

For the treatment of mild to moderate acute malaria caused by Mefloquineuine-susceptible strains of Plasmodium falciparum (both chloroquine-susceptible and resistant strains) or by Plasmodium vivax. Also for the prophylaxis of Plasmodium falciparum and Plasmodium vivax malaria infections, including prophylaxis of chloroquine-resistant strains of Plasmodium falciparum.

Mechanism of action

Mefloquine has been found to produce swelling of the Plasmodium falciparum food vacuoles. It may act by forming toxic complexes with free heme that damage membranes and interact with other plasmodial components.

Absorption

Well absorbed from the gastrointestinal tract. The presence of food significantly enhances the rate and extent of absorption.

Protein binding

98%

Biotransformation

Hepatic. Two metabolites have been identified in humans. The main metabolite, 2,8-bis-trifluoromethyl-4-quinoline carboxylic acid, is inactive against Plasmodium falciparum. The second metabolite, an alcohol, is present in minute quantities.

Route of elimination

There is evidence that mefloquine is excreted mainly in the bile and feces. Urinary excretion of unchanged mefloquine and its main metabolite under steady-state condition accounted for about 9% and 4% of the dose, respectively.

Toxicity

Oral, rat: LD₅₀ = 880 mg/kg. Symptoms of overdose include nausea, vomiting, and weight loss.

Affected organisms

Plasmodium

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Mefloquine may increase the anticoagulant effect of acenocoumarol.
Anisindione	Mefloquine may increase the anticoagulant effect of anisindione.
Artemether	Mefloquine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Dicumarol	Mefloquine may increase the anticoagulant effect of dicumarol.
Halofantrine	Increased risk of cardiac toxicity
Lumefantrine	Mefloquine may increase the adverse effects of lumefantrine. Combination therapy is contraindicated unless there are no other treatment options.
Rifampin	Rifampin lowers mefloquine levels
Ritonavir	Mefloquine decreases the effect of ritonavir
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telithromycin	Telithromycin may reduce clearance of Mefloquine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Mefloquine if Telithromycin is initiated, discontinued or dose changed.
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tiagabine	Mefloquine increases the risk of seizure and is contraindicated in persons with a history of convulsions. Possible reduction in the therapeutic effect of Tiagabine when used for other indications may also occur.
Topotecan	The p-glycoprotein inhibitor, Mefloquine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimipramine	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Vigabatrin	Mefloquine may decrease the serum concentration of Vigabatrin. This may increase the risk of seizure in patients receiving Vigabatrin to prevent seizures. Consider alternate therapy or monitor for changes in Vigabatrin serum concentration, therapeutic or adverse effects if Mefloquin is initiated, discontinued or dose changed.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of mefloquine by decreasing its metabolism. Additive QTc prolongation may also occur. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of mefloquine if voriconazole is initiated, discontinued or dose changed.
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Warfarin	Mefloquine may increase the anticoagulant effect of warfarin.
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zonisamide	Mefloquine may decrease the serum concentration and therapeutic effect of zonisamide. Concomitant therapy is contraindicated in patients with history of convulsions.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Take with food.
Avoid alcohol.
Take with a full glass of water.

Ferriprotoporphyrin IX
Name	Ferriprotoporphyrin IX
Gene Name	Not Available
Pharmacological action	yes
Actions	antagonist
References	Fitch CD: Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs. Life Sci. 2004 Mar 5;74(16):1957-72. - Pubmed
DTHybrid score	Not Available
Hemoglobin subunit alpha
Name	Hemoglobin subunit alpha
Gene Name	HBA1
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.8533
Adenosine A2a receptor
Name	Adenosine A2a receptor
Gene Name	ADORA2A
Pharmacological action	unknown
Actions	antagonist
References	Gillespie RJ, Adams DR, Bebbington D, Benwell K, Cliffe IA, Dawson CE, Dourish CT, Fletcher A, Gaur S, Giles PR, Jordan AM, Knight AR, Knutsen LJ, Lawrence A, Lerpiniere J, Misra A, Porter RH, Pratt RM, Shepherd R, Upton R, Ward SE, Weiss SM, Williamson DS: Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2916-9. Epub 2008 Mar 30. - Pubmed
DTHybrid score	0.5384

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5022
Cholinesterase
Name	Cholinesterase
Gene Name	BCHE
Actions	inhibitor
References	Lim LY, Go ML: The anticholinesterase activity of mefloquine. Clin Exp Pharmacol Physiol. 1985 Sep-Oct;12(5):527-31. - Pubmed Zhou C, Xiao C, McArdle JJ, Ye JH: Mefloquine enhances nigral gamma-aminobutyric acid release via inhibition of cholinesterase. J Pharmacol Exp Ther. 2006 Jun;317(3):1155-60. Epub 2006 Feb 24. - Pubmed McArdle JJ, Sellin LC, Coakley KM, Potian JG, Quinones-Lopez MC, Rosenfeld CA, Sultatos LG, Hognason K: Mefloquine inhibits cholinesterases at the mouse neuromuscular junction. Neuropharmacology. 2005 Dec;49(8):1132-9. Epub 2005 Aug 2. - Pubmed
DTHybrid score	0.7163
Cytochrome P450 19A1
Name	Cytochrome P450 19A1
Gene Name	CYP19A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3659
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3639
Acetylcholinesterase
Name	Acetylcholinesterase
Gene Name	ACHE
Actions	inhibitor
References	Lim LY, Go ML: The anticholinesterase activity of mefloquine. Clin Exp Pharmacol Physiol. 1985 Sep-Oct;12(5):527-31. - Pubmed
DTHybrid score	1.1201

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Fujita R, Ishikawa M, Takayanagi M, Takayanagi Y, Sasaki K: Enhancement of doxorubicin activity in multidrug-resistant cells by mefloquine. Methods Find Exp Clin Pharmacol. 2000 Jun;22(5):281-4. - Pubmed
DTHybrid score	0.3556

Id	Partner name	Gene Name	Score
693	Hemoglobin subunit beta	HBB	0.6983
4200	Cytochrome P450 1A2	CYP1A2	0.1842
16	Adenosine A1 receptor	ADORA1	0.1568
4757	Cytochrome P450 2C9	CYP2C9	0.1482
6016	Cytochrome P450 2C19	CYP2C19	0.1352
4118	Cytochrome P450 3A5	CYP3A5	0.127
4924	Cytochrome P450 2C8	CYP2C8	0.1163
6013	Cytochrome P450 2E1	CYP2E1	0.1023
6030	Cytochrome P450 2B6	CYP2B6	0.0956
6107	Cytochrome P450 3A7	CYP3A7	0.0952
268	Adenosine A2b receptor	ADORA2B	0.0886
146	Androgen receptor	AR	0.073
6024	Cytochrome P450 1A1	CYP1A1	0.0649
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0641
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0582
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.056
5718	Cytochrome P450 2A6	CYP2A6	0.0559
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0558
443	Ferritin heavy chain	FTH1	0.0541
766	Beta-2 adrenergic receptor	ADRB2	0.0529
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0523
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0522
136	Estrogen receptor	ESR1	0.0498
556	Alpha-1A adrenergic receptor	ADRA1A	0.0495
587	Serum albumin	ALB	0.0488
492	Histamine H1 receptor	HRH1	0.0475
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0474
6145	Solute carrier family 22 member 1	SLC22A1	0.0464
831	D(2) dopamine receptor	DRD2	0.0464
95	Ferritin light chain	FTL	0.0463
824	Sodium-dependent serotonin transporter	SLC6A4	0.0433
871	Glucocorticoid receptor	NR3C1	0.0397
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0397
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0393
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0392
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0384
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0375
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0371
3454	Esterase	estA	0.0353
6144	Solute carrier family 22 member 2	SLC22A2	0.0346
1898	Cytochrome P450 1B1	CYP1B1	0.0345
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0344
566	Serotransferrin	TF	0.0336
260	Cytochrome P450 51	ERG11	0.0336
761	Cytochrome P450 51	ERG11	0.0336
3163	Cytochrome P450 51	cyp51	0.0336
756	Sex hormone-binding globulin	SHBG	0.0334
862	Multidrug resistance-associated protein 1	ABCC1	0.0328
5259	Transcriptional regulator	ntrC1	0.0327
6699	Transcriptional regulator	Cgl2612	0.0327
20	Prostaglandin G/H synthase 1	PTGS1	0.0325
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0316
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0306
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0305
847	Mu-type opioid receptor	OPRM1	0.0301
3957	Adenosine deaminase	ADA	0.0296
4122	Histone deacetylase 2	HDAC2	0.0295
193	Beta-1 adrenergic receptor	ADRB1	0.0295
6143	Solute carrier family 22 member 7	SLC22A7	0.0292
118	Organic cation/carnitine transporter 2	SLC22A5	0.0287
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0279
4264	Alpha-L-fucosidase, putative	TM_0306	0.0278
713	Sodium-dependent dopamine transporter	SLC6A3	0.0274
318	Alpha-2A adrenergic receptor	ADRA2A	0.0271
290	Prostaglandin G/H synthase 2	PTGS2	0.0269
23	D(1A) dopamine receptor	DRD1	0.0266
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0261
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0258
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0256
614	Progesterone receptor	PGR	0.0252
390	Adenosine A3 receptor	ADORA3	0.0241
1830	5'-nucleotidase	NT5E	0.0241
776	Bile salt export pump	ABCB11	0.0241
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0235
6106	Cytochrome P450 2C18	CYP2C18	0.0231
3941	Amine oxidase [flavin-containing] A	MAOA	0.0228
563	Thyroid peroxidase	TPO	0.0222
632	Alpha-1B adrenergic receptor	ADRA1B	0.022
467	Delta-type opioid receptor	OPRD1	0.0218
638	D(3) dopamine receptor	DRD3	0.0217
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0216
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0214
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0213
6794	Uncharacterized lipoprotein ybbD	ybbD	0.0213
2662	Glutamate racemase	murI	0.0213
6299	Glutamate racemase	murI	0.0213
6641	Glutamate racemase	murI	0.0213
6771	Glutamate racemase	murI	0.0213
6892	Glutamate racemase	murI	0.0213
6795	Phosphoenolpyruvate-protein phosphotransferase	ptsP	0.0213
435	Kynureninase	KYNU	0.0213
4654	Kynureninase	kynU	0.0213
2433	Capsid protein P40	UL80	0.0213
3569	Capsid protein P40	BVRF2	0.0213
4116	Dihydropteroate synthetase	Not Available	0.0209
244	Angiotensin-converting enzyme	ACE	0.0209
1729	Solute carrier family 22 member 6	SLC22A6	0.0207
465	Calmodulin	CALM1	0.0203
226	Gonadotropin-releasing hormone receptor	GNRHR	0.02
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0199
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0195
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0195
2049	Gastrin/cholecystokinin type B receptor	CCKBR	0.0191
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0189
731	HIV-1 protease	HIV-1 protease	0.0188
6171	Solute carrier family 28 member 3	SLC28A3	0.0188
6021	Adenosine kinase	ADK	0.0187
3076	Antigen 85-C	fbpC	0.0187
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0185
6142	Solute carrier family 22 member 8	SLC22A8	0.0185
131	Synaptic vesicular amine transporter	SLC18A2	0.0184
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0184
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0182
436	5-hydroxytryptamine 2B receptor	HTR2B	0.018
629	Alpha-2B adrenergic receptor	ADRA2B	0.0179
696	Kappa-type opioid receptor	OPRK1	0.0178
1656	CYP2B protein	CYP2B	0.0176
148	Lutropin-choriogonadotropic hormone receptor	LHCGR	0.0175
6147	Solute carrier family 22 member 3	SLC22A3	0.0174
833	Organic cation/carnitine transporter 1	SLC22A4	0.0172
124	Histamine H2 receptor	HRH2	0.0171
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0169
3939	Amine oxidase [flavin-containing] B	MAOB	0.0167
2517	Subtilisin BPN'	apr	0.0155
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0155
3947	Xanthine dehydrogenase/oxidase	XDH	0.0154
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0154
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0153
380	Cytochrome P450 17A1	CYP17A1	0.0147
2796	Parathion hydrolase	opd	0.0147
6539	Parathion hydrolase	opd	0.0147
869	Estrogen receptor beta	ESR2	0.0146
232	Corticosteroid-binding globulin	SERPINA6	0.0146
814	Ryanodine receptor 1	RYR1	0.0143
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0141
789	Alpha-1D adrenergic receptor	ADRA1D	0.0141
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0138
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0136
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0135
817	DNA topoisomerase 2-alpha	TOP2A	0.0135
6044	Serum paraoxonase/lactonase 3	PON3	0.0132
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0126
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0125
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0124
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0124
2929	(S)-2-haloacid dehalogenase	dhlB	0.0124
2995	(S)-2-haloacid dehalogenase	Not Available	0.0124
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0124
468	Cytochrome P450 4A11	CYP4A11	0.0124
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0124
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0124
6182	Cytochrome P450 2J2	CYP2J2	0.0121
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0121
4604	Liver carboxylesterase 1	CES1	0.0121
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0119
844	Epidermal growth factor receptor	EGFR	0.0119
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0116
378	Alpha-2C adrenergic receptor	ADRA2C	0.0116
6031	Cytochrome P450 3A43	CYP3A43	0.0112
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0111
2164	Multidrug resistance-associated protein 4	ABCC4	0.0109
737	Mineralocorticoid receptor	NR3C2	0.0104
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0104
432	D(4) dopamine receptor	DRD4	0.0103
952	Dipeptidyl peptidase 4	DPP4	0.01
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0097
161	Tubulin beta chain	TUBB	0.0097
312	Tubulin beta chain	TUB2	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
275	Arachidonate 5-lipoxygenase	ALOX5	0.0097
6148	Multidrug resistance-associated protein 7	ABCC10	0.0095
4787	Envelope glycoprotein gp160	env	0.0094
4820	Envelope glycoprotein gp160	env	0.0094
5727	Envelope glycoprotein gp160	env	0.0094
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0093
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0092
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0091
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0089
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0089
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0088
3176	Trypsin-1	PRSS1	0.0086
1192	Sulfotransferase 1A1	SULT1A1	0.0086
1010	Cytochrome P450 51A1	CYP51A1	0.0085
29	Tubulin beta-1 chain	TUBB1	0.0085
818	50S ribosomal protein L10	rplJ	0.0085
6137	Multidrug resistance-associated protein 6	ABCC6	0.0084
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0083
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0083
6020	Aldehyde oxidase	AOX1	0.0083
504	Mast/stem cell growth factor receptor	KIT	0.0081
716	5-hydroxytryptamine 7 receptor	HTR7	0.008
1353	DNA topoisomerase 1	TOP1	0.008
3552	DNA topoisomerase 1	topA	0.008
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0079
122	P2Y purinoceptor 12	P2RY12	0.0079
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0078
373	Transthyretin	TTR	0.0078
85	Growth hormone receptor	GHR	0.0077
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0076
4120	NADPH--cytochrome P450 reductase	POR	0.0076
6141	Sodium/bile acid cotransporter	SLC10A1	0.0075
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0075
163	D(1B) dopamine receptor	DRD5	0.0075
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0075
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0073
6136	Multidrug resistance-associated protein 5	ABCC5	0.0073
1517	Beta-3 adrenergic receptor	ADRB3	0.0072
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0072
1024	Solute carrier family 22 member 11	SLC22A11	0.0072
3626	Probable polysaccharide deacetylase pdaA	pdaA	0.0071
1649	Small inducible cytokine A2	CCL2	0.007
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0069
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0067
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0067
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0067
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0067
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0067
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0067
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0066
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0064
1852	Microtubule-associated protein 2	MAP2	0.0064
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0064
780	Retinoic acid receptor RXR-gamma	RXRG	0.0063
3809	Estrogen-related receptor gamma	ESRRG	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
4237	50S ribosomal protein L22	rplV	0.0062
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0062
2449	Tubulin alpha-3 chain	TUBA1A	0.0062
2112	Toll-like receptor 9	TLR9	0.0062
407	Vascular endothelial growth factor receptor 2	KDR	0.0062
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0062
4666	Fucose-binding lectin PA-IIL	lecB	0.0062
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0061
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.006
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.006
4785	Ig gamma-1 chain C region	IGHG1	0.006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
777	Tumor necrosis factor	TNF	0.0059
70	Type-1 angiotensin II receptor	AGTR1	0.0059
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0059
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0059
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
5934	Cytochrome P450 26A1	CYP26A1	0.0058
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0058
88	Retinoic acid receptor RXR-beta	RXRB	0.0058
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0058
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0058
634	Squalene monooxygenase	SQLE	0.0057
7196	Squalene monooxygenase	ERG1	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0057
26	Vascular endothelial growth factor receptor 3	FLT4	0.0057
1373	Glucosylceramidase	GBA	0.0056
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0056
459	Retinoic acid receptor RXR-alpha	RXRA	0.0056
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0056
904	Glutathione S-transferase P	GSTP1	0.0055
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0055
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0055
6506	Stathmin-4	STMN4	0.0055
32	Vascular endothelial growth factor receptor 1	FLT1	0.0054
477	DNA topoisomerase 4 subunit A	parC	0.0054
886	DNA topoisomerase 4 subunit A	parC	0.0054
6226	DNA topoisomerase 4 subunit A	parC	0.0054
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0054
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0054
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0053
404	DNA gyrase subunit A	gyrA	0.0053
6224	DNA gyrase subunit A	gyrA	0.0053
6014	Cytochrome P450 2A13	CYP2A13	0.0052
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0052
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0052
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0051
229	Retinoic acid receptor beta	RARB	0.0051
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
1256	5-hydroxytryptamine 6 receptor	HTR6	0.005
730	Retinoic acid receptor alpha	RARA	0.005
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.005
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.005
173	Toll-like receptor 7	TLR7	0.0049
162	Retinoic acid receptor gamma-1	RARG	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0048
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0047
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0047
4238	50S ribosomal protein L4	rplD	0.0047
5578	50S ribosomal protein L4	rplD	0.0047
6173	50S ribosomal protein L4	rplD	0.0047
6219	50S ribosomal protein L4	rplD	0.0047
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0047
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0047
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0047
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
4784	Beta-mannosidase	manB	0.0046
6695	Beta-mannosidase	BT_0458	0.0046
68	Cannabinoid receptor 1	CNR1	0.0045
1629	Transcription factor AP-1	JUN	0.0045
811	Translocator protein	TSPO	0.0044
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0044
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0044
738	Monocarboxylate transporter 1	SLC16A1	0.0044
365	Dihydrofolate reductase	DHFR	0.0044
2381	Dihydrofolate reductase	DFR1	0.0044
2833	Dihydrofolate reductase	Not Available	0.0044
2931	Dihydrofolate reductase	folA	0.0044
3544	Dihydrofolate reductase	folA	0.0044
3682	Dihydrofolate reductase	folA	0.0044
6642	Dihydrofolate reductase	folA	0.0044
6756	Dihydrofolate reductase	dfrA	0.0044
6138	Multidrug resistance protein 3	ABCB4	0.0043
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0043
5923	Microtubule-associated protein tau	MAPT	0.0042
5924	Microtubule-associated protein 4	MAP4	0.0042
3810	Catechol O-methyltransferase	COMT	0.0042
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0042
1757	Myeloperoxidase	MPO	0.0042
6220	Aryl hydrocarbon receptor	AHR	0.0042
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0042
768	FK506-binding protein 1A	FKBP1A	0.0042
94	5-hydroxytryptamine 4 receptor	HTR4	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0041
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0041
273	Apoptosis regulator Bcl-2	BCL2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
856	Vitamin D3 receptor	VDR	0.004
5251	Carbonyl reductase [NADPH] 1	CBR1	0.004
7	Nitric oxide synthase, inducible	NOS2	0.004
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.004
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.004
4203	Histamine N-methyltransferase	HNMT	0.004
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.004
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.004
469	Annexin A1	ANXA1	0.0039
3814	Complement C1r subcomponent	C1R	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
295	Carbonic anhydrase 1	CA1	0.0039
3426	Glutamine synthetase	glnA	0.0039
3987	Glutamine synthetase	GLUL	0.0039
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0039
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0039
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0039
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0039
861	Choline kinase alpha	CHKA	0.0039
700	Choline dehydrogenase, mitochondrial	CHDH	0.0039
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0039
1686	Choline transporter-like protein 1	SLC44A1	0.0039
3927	Choline transporter-like protein 3	SLC44A3	0.0039
3926	Choline transporter-like protein 2	SLC44A2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
576	Choline O-acetyltransferase	CHAT	0.0039
769	High-affinity choline transporter 1	SLC5A7	0.0039
3925	Choline transporter-like protein 4	SLC44A4	0.0039
3922	Phospholipase D2	PLD2	0.0039
3924	Phospholipase D1	PLD1	0.0039
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0039
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0039
592	Carbonic anhydrase 4	CA4	0.0038
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0037
2539	Tubulin alpha-1 chain	TUBA4A	0.0037
891	Dihydropteroate synthase	folP	0.0037
5359	Dihydropteroate synthase	folP	0.0037
7175	Dihydropteroate synthase	sulI	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0037
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0037
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0037
2782	Complement C1s subcomponent	C1S	0.0037
6167	Organic solute transporter subunit beta	OSTB	0.0037
6166	Organic solute transporter subunit alpha	OSTA	0.0037
3932	Glutathione S-transferase A2	GSTA2	0.0036
1050	Bile salt sulfotransferase	SULT2A1	0.0036
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0035
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
319	Opioid receptor, sigma 1	OPRS1	0.0035
6131	Carbonic anhydrase 14	CA14	0.0035
939	50S ribosomal protein L3	rplC	0.0035
3815	Complement C1q subcomponent subunit A	C1QA	0.0034
3816	Complement C1q subcomponent subunit B	C1QB	0.0034
3817	Complement C1q subcomponent subunit C	C1QC	0.0034
2297	Genome polyprotein	Not Available	0.0034
2322	Genome polyprotein	Not Available	0.0034
2694	Genome polyprotein	Not Available	0.0034
2719	Genome polyprotein	Not Available	0.0034
2860	Genome polyprotein	Not Available	0.0034
2928	Genome polyprotein	Not Available	0.0034
3160	Genome polyprotein	Not Available	0.0034
3260	Genome polyprotein	Not Available	0.0034
4783	Genome polyprotein	Not Available	0.0034
5726	Genome polyprotein	Not Available	0.0034
5779	Genome polyprotein	Not Available	0.0034
5867	Genome polyprotein	Not Available	0.0034
6253	Genome polyprotein	Not Available	0.0034
6301	Genome polyprotein	Not Available	0.0034
6380	Genome polyprotein	Not Available	0.0034
6381	Genome polyprotein	Not Available	0.0034
6437	Genome polyprotein	Not Available	0.0034
6520	Genome polyprotein	Not Available	0.0034
6521	Genome polyprotein	Not Available	0.0034
6652	Genome polyprotein	Not Available	0.0034
6734	Genome polyprotein	Not Available	0.0034
6735	Genome polyprotein	Not Available	0.0034
6736	Genome polyprotein	Not Available	0.0034
6737	Genome polyprotein	Not Available	0.0034
6738	Genome polyprotein	Not Available	0.0034
6739	Genome polyprotein	Not Available	0.0034
6744	Genome polyprotein	Not Available	0.0034
6748	Genome polyprotein	Not Available	0.0034
6894	Genome polyprotein	Not Available	0.0034
6898	Genome polyprotein	Not Available	0.0034
2207	Rhodopsin	RHO	0.0034
6102	Arylamine N-acetyltransferase 2	NAT2	0.0034
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0034
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0034
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0034
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0034
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0034
3830	Calreticulin	CALR	0.0034
4103	Proteasome subunit beta type 2	PSMB2	0.0034
4102	Proteasome subunit beta type 5	PSMB5	0.0034
4101	Proteasome subunit beta type 1	PSMB1	0.0034
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0034
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.0034
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0034
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0034
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0034
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0034
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0034
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
6432	Transporter	snf	0.0033
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0033
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0033
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0033
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0033
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0032
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0032
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0032
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0032
284	DNA-directed RNA polymerase beta chain	rpoB	0.0032
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0032
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0032
165	FL cytokine receptor	FLT3	0.0032
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0032
3856	Fibroblast growth factor receptor 3	FGFR3	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
84	Nuclear receptor 0B1	NR0B1	0.0032
6035	Nuclear receptor ROR-beta	RORB	0.0032
6034	Hydroxyindole O-methyltransferase	ASMT	0.0032
6036	Eosinophil peroxidase	EPX	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
6824	Tyrosine-protein kinase Lyn	LYN	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
3437	Eosinophil lysophospholipase	CLC	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
239	Coagulation factor X	F10	0.003
705	Glutamate receptor 1	GRIA1	0.003
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.003
5449	Hypothetical gliding protein	mglB	0.003
5443	UPF0189 protein ymdB	ymdB	0.003
5440	UPF0067 protein yebR	yebR	0.003
5439	33 kDa chaperonin	hslO	0.003
4705	Manganese catalase	Not Available	0.003
2720	Copper-containing nitrite reductase	nirK	0.003
3781	Thiol:disulfide interchange protein dsbC precursor	dsbC	0.003
5446	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	HI_1679	0.003
5448	Ribonuclease Z	rnz	0.003
332	Beta-lactamase	blaZ	0.003
2478	Beta-lactamase	ampC	0.003
2613	Beta-lactamase	ampC	0.003
2635	Beta-lactamase	ampC	0.003
2700	Beta-lactamase	penP	0.003
5445	Beta-lactamase	blaB	0.003
6019	Beta-lactamase	SHV-7	0.003
6701	Beta-lactamase	cphA	0.003
5447	Lethal(3)malignant brain tumor-like protein	L3MBTL1	0.003
5454	Internalin-A	inlA	0.003
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.003
174	Sigma 1-type opioid receptor	SIGMAR1	0.0029
4498	Ornithine cyclodeaminase	PP3533	0.0029
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0029
357	Carbonic anhydrase 2	CA2	0.0029
4773	Deoxycytidine kinase	DCK	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
24	Thymidylate synthase	TMP1	0.0027
359	Thymidylate synthase	TYMS	0.0027
2626	Thymidylate synthase	thyA	0.0027
2729	Thymidylate synthase	thyA	0.0027
5352	Thymidylate synthase	THYA	0.0027
765	Indoleamine 2,3-dioxygenase	IDO1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
5450	Prolyl endopeptidase Pep	pep	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
267	Plasminogen activator inhibitor 1	SERPINE1	0.0026
5300	Antigen peptide transporter 1	TAP1	0.0026
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0026
3356	Diaminopimelate decarboxylase	lysA	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
4771	Dissimilatory copper-containing nitrite reductase	nir	0.0026
2714	Chorismate mutase	aroH	0.0026
4611	Chorismate mutase	aroG	0.0026
3274	Hydroxylamine reductase	hcp	0.0026
4804	Hydroxylamine reductase	hcp	0.0026
49	Endothelin B receptor	EDNRB	0.0026
427	Substance-P receptor	TACR1	0.0026
6146	High affinity copper uptake protein 1	SLC31A1	0.0025
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0025
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0025
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0025
6085	Fatty acid-binding protein, intestinal	FABP2	0.0025
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
597	Dihydropteridine reductase	QDPR	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1618	High affinity nerve growth factor receptor	NTRK1	0.0024
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6221	Steroid hormone receptor ERR1	ESRRA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
3399	Limonene-1,2-epoxide hydrolase	limA	0.0024
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
5787	Angiopoietin-1 receptor	TEK	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
4608	Putative cytochrome P450	SCO1207	0.0023
4963	Putative cytochrome P450	SCO2884	0.0023
6254	Putative cytochrome P450	SCO6998	0.0023
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0023
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0023
5180	L(+)-mandelate dehydrogenase	mdlB	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
3500	Putative family 31 glucosidase yicI	yicI	0.0023
291	Nitric-oxide synthase, endothelial	NOS3	0.0022
2599	Tyrosine-protein kinase HCK	HCK	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
1262	Corticotropin-lipotropin	POMC	0.0022
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
908	Glutathione S-transferase theta-1	GSTT1	0.0022
577	Argininosuccinate lyase	ASL	0.0022
1615	Chymase	CMA1	0.0022
581	Cytochrome P450 2R1	CYP2R1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0022
3404	Exotoxin A	eta	0.0022
298	Renin	REN	0.0021
896	Glutathione S-transferase Mu 1	GSTM1	0.0021
2300	Lysozyme	E	0.0021
3633	Lysozyme	R	0.0021
5597	Lysozyme	17	0.0021
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0021
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
4311	tRNA	TRDMT1	0.0021
4325	tRNA	trmD	0.0021
4328	tRNA	trmD	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
6126	Carbonic anhydrase 7	CA7	0.002
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.002
164	Histamine H4 receptor	HRH4	0.002
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.002
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.002
482	Glycine receptor subunit alpha-1	GLRA1	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
54	Prothrombin	F2	0.0019
6149	Solute carrier family 22 member 10	SLC22A10	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
65	Matrix metalloproteinase-9	Not Available	0.0019
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0019
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0019
183	Vascular endothelial growth factor A	VEGFA	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0018
823	Fibroblast growth factor receptor 2	FGFR2	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
1630	Integrin beta-2	ITGB2	0.0017
976	Platelet glycoprotein IX	GP9	0.0017
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
6163	Copper-transporting ATPase 2	ATP7B	0.0017
6165	Copper-transporting ATPase 1	ATP7A	0.0017
518	Peroxidase/catalase T	katG	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
6174	50S ribosomal protein L32	rpmF	0.0016
2216	Fibroblast growth factor receptor 4	FGFR4	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0016
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0016
3233	Bile acid receptor	NR1H4	0.0015
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0015
4192	DNA topoisomerase 2-beta	TOP2B	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
936	Ephrin type-A receptor 2	EPHA2	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0014
1541	Metalloproteinase	mmp20	0.0014
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0014
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
153	Dopamine beta-hydroxylase	DBH	0.0013
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0013
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0013
921	Glutamate receptor 2	GRIA2	0.0013
572	Integrin alpha-L	ITGAL	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0013
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
1864	RET proto-oncogene	RET	0.0012
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0012
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0012
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0012
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0012
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1275	Estrogen sulfotransferase	SULT1E1	0.0012
1295	Fatty acid synthase	FASN	0.0012
6151	Monocarboxylate transporter 10	SLC16A10	0.0012
760	Fibroblast growth factor 1	FGF1	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6859	Protein S100-A4	S100A4	0.0012
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0012
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0011
484	Tyrosine-protein kinase ABL2	ABL2	0.0011
1992	Vitamin D-binding protein	GC	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
751	Potassium channel subfamily K member 6	KCNK6	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0011
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6459	Glycodelin	PAEP	0.0011
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3937	Fatty-acid amide hydrolase	FAAH	0.001
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.001
1063	Signal transducer and activator of transcription 5B	STAT5B	0.001
4217	Telomerase reverse transcriptase	TERT	0.001
76	Nitric-oxide synthase, brain	NOS1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
172	Potassium channel subfamily K member 1	KCNK1	0.001
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.001
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0009
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0009
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0009
6168	Solute carrier family 22 member 16	SLC22A16	0.0009
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0009
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0009
4878	Glycoprotein hormones alpha chain	CGA	0.0009
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0009
1072	Granzyme B	GZMB	0.0009
4889	Ig epsilon chain C region	IGHE	0.0009
4877	Beta-mannanase	man	0.0009
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0009
4189	Alpha-galactosidase A	GLA	0.0009
4850	Beta-2-glycoprotein 1	APOH	0.0009
4880	Membrane cofactor protein	CD46	0.0009
4856	CD209 antigen	CD209	0.0009
1354	Beta-glucuronidase	GUSB	0.0009
757	Fusion glycoprotein F0	F	0.0009
4875	Fusion glycoprotein F0	F	0.0009
4869	Major capsid protein	A430L	0.0009
4852	Reticulon-4 receptor	RTN4R	0.0009
4845	ADAM 33	ADAM33	0.0009
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0009
442	Envelope glycoprotein	gp41	0.0009
4859	Envelope glycoprotein	env	0.0009
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0009
4721	Beta-1,4-mannanase	manA	0.0009
3352	Structural polyprotein	Not Available	0.0009
3628	Structural polyprotein	Not Available	0.0009
4892	Structural polyprotein	Not Available	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
2132	Protein S100-B	S100B	0.0009
489	Monocarboxylate transporter 2	SLC16A7	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
1867	Major prion protein	PRNP	0.0008
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4861	Interleukin-6 receptor alpha chain	IL6R	0.0008
793	T-cell surface antigen CD2	CD2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0008
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0008
3837	Cytokine receptor common beta chain	CSF2RB	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0007
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0007
1268	Neuropeptide S receptor	NPSR1	0.0007
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0007
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0007
6218	Pannexin-1	PANX1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
4890	Hemagglutinin	HA	0.0007
6566	Hemagglutinin	Not Available	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
1379	Interleukin-12 subunit beta	IL12B	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0007
6858	Inactive carboxylesterase 4	CES1P1	0.0007
1184	Interferon beta	IFNB1	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0006
6072	Potassium channel subfamily K member 3	KCNK3	0.0006
6500	Phospholipase A2	PLA2G1B	0.0006
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
554	Low-density lipoprotein receptor	LDLR	0.0006
852	Heparin cofactor 2	SERPIND1	0.0006
33	Cystine/glutamate transporter	SLC7A11	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
1859	Prostatic acid phosphatase	ACPP	0.0006
3444	Cyanovirin-N	Not Available	0.0006
3140	Hemagglutinin-neuraminidase	HN	0.0006
3609	Hemagglutinin-neuraminidase	HN	0.0006
595	Fibrinogen alpha chain	FGA	0.0006
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0006
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0006
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0005
2372	Bifunctional tail protein	9	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
958	Insulin-like growth factor 1 receptor	IGF1R	0.0005
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2021	Thrombomodulin	THBD	0.0005
3221	Cytochrome c4	cc4	0.0005
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0005
64	Neuraminidase	NA	0.0005
641	Neuraminidase	NA	0.0005
2676	Neuraminidase	NA	0.0005
3026	Neuraminidase	NA	0.0005
3519	Neuraminidase	NA	0.0005
6007	Neuraminidase	NA	0.0005
1243	Cathepsin D	CTSD	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
517	Alcohol dehydrogenase 1C	ADH1C	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
1439	Lactotransferrin	LTF	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0005
309	Antithrombin-III	SERPINC1	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
2430	Chondroitinase B	cslB	0.0004
6307	Ig gamma-2 chain C region	IGHG2	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
2581	Chondroitinase AC	cslA	0.0004
6847	Lactase-phlorizin hydrolase	LCT	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
1650	Heme carrier protein 1	SLC46A1	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00358 - Mefloquine

Targets

Enzymes

Transporters

Predictions