DT-Web: DB00468

Identification

Name

Quinine

Accession Number

DB00468 (APRD00563)

Type

small molecule

Description

An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

324.4168

Groups

approved

Monoisotopic Weight

324.183778022

Pharmacology

Indication

For the treatment of malaria and leg cramps

Mechanism of action

The theorized mechanism of action for quinine and related anti-malarial drugs is that these drugs are toxic to the malaria parasite. Specifically, the drugs interfere with the parasite's ability to break down and digest hemoglobin. Consequently, the parasite starves and/or builds up toxic levels of partially degraded hemoglobin in itself.

Absorption

76 - 88%

Protein binding

Approximately 70%

Biotransformation

Hepatic, over 80% metabolized by the liver.

Route of elimination

Quinine is eliminated primarily via hepatic biotransformation. Approximately 20% of quinine is excreted unchanged in urine.

Toxicity

Quinine is a documented causative agent of drug induced thrombocytopenia (DIT). Thrombocytopenia is a low amount of platelets in the blood. Quinine induces production of antibodies against glycoprotein (GP) Ib-IX complex in the majority of cases of DIT, or more rarely, the platelet-glycoprotein complex GPIIb-IIIa. Increased antibodies against these complexes increases platelet clearance, leading to the observed thrombocytopenia.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Quinine, a moderate CYP2C9 inhibitor, may increase the serum concentration of acenocoumarol by decreasing its metabolism via CYP2C9.
Anisindione	Quinine may increase the anticoagulant effect of anisindione.
Artemether	Quinine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Astemizole	Increased risk of cardiotoxicity and arrhythmias
Atomoxetine	The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Atracurium	The quinine derivative increases the effect of the muscle relaxant
Dicumarol	Quinine may increase the anticoagulant effect of dicumarol.
Digitoxin	Quinine/quinidine increases the effect of digoxin
Digoxin	Quinine/quinidine increases the effect of digoxin
Lumefantrine	Quinine may increase the adverse effects of lumefantrine. Combination therapy is contraindicated unless there are no other treatment options.
Mesoridazine	Increased risk of cardiotoxicity and arrhythmias
Metocurine	The quinine derivative increases the effect of the muscle relaxant
Pancuronium	The quinine derivative increases the effect of the muscle relaxant
Succinylcholine	The quinine derivative increases the effect of the muscle relaxant
Tamoxifen	Quinine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin	Quinine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Quinine is initiated, discontinued, or dose changed.
Telithromycin	Telithromycin may reduce clearance of Quinine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Quinine if Telithromycin is initiated, discontinued or dose changed.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Thiothixene	May cause additive QTc-prolonging effects. Concomitant therapy should be avoided.
Toremifene	May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Tramadol	Quinine may decrease the effect of Tramadol by decreasing active metabolite production.
Trandolapril	May cause additive hypotensive effects. Monitor for changes in blood pressure if Quinine is initiated, discontinued or dose changed.
Tretinoin	The moderate CYP2C8 inhibitor, Quinine, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Quinine is initiated, discontinued to dose changed.
Vecuronium	Quinine may increase the neuromuscular blocking action of Vecuronium. Risk of respiratory depression and apnea. Concurrent therapy should be avoided.
Voriconazole	Additive QTc prolongation may occur. Concomitant therapy should be avoided.
Vorinostat	Additive QTc prolongation may occur. Concomitant therapy should be avoided.
Warfarin	Quinine, a moderate CYP2C9 inhibitor, may increase the serum concentration of S-warfarin by decreasing its metabolism via CYP2C9.
Ziprasidone	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Zuclopenthixol	Additive QTc-prolonging effects increases risk of cardiac arrhythmias. Concomitant therapy should be avoided.

Food Interactions

Take with food to reduce irritation.

Ferriprotoporphyrin IX
Name	Ferriprotoporphyrin IX
Gene Name	Not Available
Pharmacological action	yes
Actions	antagonist
References	Alumasa JN, Gorka AP, Casabianca LB, Comstock E, de Dios AC, Roepe PD: The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex. J Inorg Biochem. 2010 Sep 21. - Pubmed Fitch CD: Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs. Life Sci. 2004 Mar 5;74(16):1957-72. - Pubmed
DTHybrid score	Not Available
Platelet glycoprotein IX
Name	Platelet glycoprotein IX
Gene Name	GP9
Pharmacological action	unknown
Actions	other
References	Asvadi P, Ahmadi Z, Chong BH: Drug-induced thrombocytopenia: localization of the binding site of GPIX-specific quinine-dependent antibodies. Blood. 2003 Sep 1;102(5):1670-7. Epub 2003 May 8. - Pubmed
DTHybrid score	0.1578
Intermediate conductance calcium-activated potassium channel protein 4
Name	Intermediate conductance calcium-activated potassium channel protein 4
Gene Name	KCNN4
Pharmacological action	unknown
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.1515

Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.6063
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor,inducer
References	AR Scientific, Inc. Qualaquin® (quinine sulfate) capsules prescribing information. Philadelphia, PA; 2008 Jun. - Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7284
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inhibitor
References	AR Scientific, Inc. Qualaquin® (quinine sulfate) capsules prescribing information. Philadelphia, PA; 2008 Jun. - Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5601
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	AR Scientific, Inc. Qualaquin® (quinine sulfate) capsules prescribing information. Philadelphia, PA; 2008 Jun. - Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T: Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. J Pharmacol Exp Ther. 1996 Dec;279(3):1327-34. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7538
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	AR Scientific, Inc. Qualaquin® (quinine sulfate) capsules prescribing information. Philadelphia, PA; 2008 Jun. - Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score	0.6765
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	AR Scientific, Inc. Qualaquin® (quinine sulfate) capsules prescribing information. Philadelphia, PA; 2008 Jun. -
DTHybrid score	0.4659
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4861
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inhibitor,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4102
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	AR Scientific, Inc. Qualaquin® (quinine sulfate) capsules prescribing information. Philadelphia, PA; 2008 Jun. - Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T: Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. J Pharmacol Exp Ther. 1996 Dec;279(3):1327-34. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score	1.0906
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	AR Scientific, Inc. Qualaquin® (quinine sulfate) capsules prescribing information. Philadelphia, PA; 2008 Jun. - Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8206

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Sweet DH, Miller DS, Pritchard JB: Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus. J Biol Chem. 2001 Nov 9;276(45):41611-9. Epub 2001 Sep 11. - Pubmed Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H: Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. - Pubmed Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50. - Pubmed Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS: The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther. 2002 Dec;303(3):959-68. - Pubmed Sweet DH, Pritchard JB: rOCT2 is a basolateral potential-driven carrier, not an organic cation/proton exchanger. Am J Physiol. 1999 Dec;277(6 Pt 2):F890-8. - Pubmed
DTHybrid score	0.3629
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	substrate,inhibitor
References	Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. - Pubmed Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50. - Pubmed Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed Sweet DH, Miller DS, Pritchard JB: Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus. J Biol Chem. 2001 Nov 9;276(45):41611-9. Epub 2001 Sep 11. - Pubmed Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS: The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther. 2002 Dec;303(3):959-68. - Pubmed Grundemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H: Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 1994 Dec 8;372(6506):549-52. - Pubmed Martel F, Vetter T, Russ H, Grundemann D, Azevedo I, Koepsell H, Schomig E: Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):320-6. - Pubmed Busch AE, Quester S, Ulzheimer JC, Gorboulev V, Akhoundova A, Waldegger S, Lang F, Koepsell H: Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1. FEBS Lett. 1996 Oct 21;395(2-3):153-6. - Pubmed Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H: Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem. 1996 Dec 20;271(51):32599-604. - Pubmed
DTHybrid score	0.4473
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score	0.3888
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed van der Sandt IC, Blom-Roosemalen MC, de Boer AG, Breimer DD: Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines. Eur J Pharm Sci. 2000 Sep;11(3):207-14. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Borgnia MJ, Eytan GD, Assaraf YG: Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. - Pubmed
DTHybrid score	0.7174
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed Kullak-Ublick, G.A. et al. Organic anion-transporting polypeptide B (OATP- B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120, 525-533 (2001). - Pubmed
DTHybrid score	0.3083
Organic cation/carnitine transporter 1
Name	Organic cation/carnitine transporter 1
Gene Name	SLC22A4
Actions	inhibitor
References	Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score	0.3016

Id	Partner name	Gene Name	Score
6030	Cytochrome P450 2B6	CYP2B6	0.3316
5718	Cytochrome P450 2A6	CYP2A6	0.2228
587	Serum albumin	ALB	0.1932
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1918
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1766
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1661
1729	Solute carrier family 22 member 6	SLC22A6	0.1498
6147	Solute carrier family 22 member 3	SLC22A3	0.147
20	Prostaglandin G/H synthase 1	PTGS1	0.1462
492	Histamine H1 receptor	HRH1	0.1391
862	Multidrug resistance-associated protein 1	ABCC1	0.137
6142	Solute carrier family 22 member 8	SLC22A8	0.1357
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1178
6106	Cytochrome P450 2C18	CYP2C18	0.1165
776	Bile salt export pump	ABCB11	0.1077
824	Sodium-dependent serotonin transporter	SLC6A4	0.1058
1898	Cytochrome P450 1B1	CYP1B1	0.1034
3811	Cytochrome P450 19A1	CYP19A1	0.0979
556	Alpha-1A adrenergic receptor	ADRA1A	0.0946
831	D(2) dopamine receptor	DRD2	0.0938
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0926
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0912
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0908
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0879
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0875
766	Beta-2 adrenergic receptor	ADRB2	0.0855
6143	Solute carrier family 22 member 7	SLC22A7	0.0837
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0811
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0804
51	Muscarinic acetylcholine receptor M3	CHRM3	0.08
290	Prostaglandin G/H synthase 2	PTGS2	0.0787
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0787
193	Beta-1 adrenergic receptor	ADRB1	0.077
318	Alpha-2A adrenergic receptor	ADRA2A	0.0759
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0755
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0746
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0715
260	Cytochrome P450 51	ERG11	0.0703
761	Cytochrome P450 51	ERG11	0.0703
3163	Cytochrome P450 51	cyp51	0.0703
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0696
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0686
817	DNA topoisomerase 2-alpha	TOP2A	0.0676
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0666
1024	Solute carrier family 22 member 11	SLC22A11	0.0664
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0664
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0661
136	Estrogen receptor	ESR1	0.0657
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0649
2164	Multidrug resistance-associated protein 4	ABCC4	0.0648
23	D(1A) dopamine receptor	DRD1	0.0646
632	Alpha-1B adrenergic receptor	ADRA1B	0.0627
871	Glucocorticoid receptor	NR3C1	0.0612
847	Mu-type opioid receptor	OPRM1	0.0611
713	Sodium-dependent dopamine transporter	SLC6A3	0.0596
477	DNA topoisomerase 4 subunit A	parC	0.0593
886	DNA topoisomerase 4 subunit A	parC	0.0593
6226	DNA topoisomerase 4 subunit A	parC	0.0593
404	DNA gyrase subunit A	gyrA	0.0583
6224	DNA gyrase subunit A	gyrA	0.0583
3941	Amine oxidase [flavin-containing] A	MAOA	0.0575
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0565
6031	Cytochrome P450 3A43	CYP3A43	0.0562
731	HIV-1 protease	HIV-1 protease	0.0559
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0557
6141	Sodium/bile acid cotransporter	SLC10A1	0.0551
629	Alpha-2B adrenergic receptor	ADRA2B	0.0522
3923	Cholinesterase	BCHE	0.0513
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0513
378	Alpha-2C adrenergic receptor	ADRA2C	0.051
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0491
468	Cytochrome P450 4A11	CYP4A11	0.0485
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.048
467	Delta-type opioid receptor	OPRD1	0.0479
3939	Amine oxidase [flavin-containing] B	MAOB	0.0459
789	Alpha-1D adrenergic receptor	ADRA1D	0.0455
6148	Multidrug resistance-associated protein 7	ABCC10	0.0453
638	D(3) dopamine receptor	DRD3	0.0452
696	Kappa-type opioid receptor	OPRK1	0.045
274	Muscarinic acetylcholine receptor M5	CHRM5	0.045
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0446
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0438
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0437
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0436
465	Calmodulin	CALM1	0.0431
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.043
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0415
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0408
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0406
124	Histamine H2 receptor	HRH2	0.0399
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0398
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0382
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0377
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0372
474	Acetylcholinesterase	ACHE	0.0368
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0366
737	Mineralocorticoid receptor	NR3C2	0.036
756	Sex hormone-binding globulin	SHBG	0.035
6182	Cytochrome P450 2J2	CYP2J2	0.0348
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0347
6137	Multidrug resistance-associated protein 6	ABCC6	0.0345
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0345
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0345
380	Cytochrome P450 17A1	CYP17A1	0.0339
146	Androgen receptor	AR	0.0338
738	Monocarboxylate transporter 1	SLC16A1	0.0334
6014	Cytochrome P450 2A13	CYP2A13	0.0332
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0329
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0322
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.032
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0318
1757	Myeloperoxidase	MPO	0.0316
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0313
6136	Multidrug resistance-associated protein 5	ABCC5	0.0311
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.031
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.031
3947	Xanthine dehydrogenase/oxidase	XDH	0.031
777	Tumor necrosis factor	TNF	0.0308
432	D(4) dopamine receptor	DRD4	0.0308
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0307
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0301
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0295
7	Nitric oxide synthase, inducible	NOS2	0.0295
4604	Liver carboxylesterase 1	CES1	0.0293
614	Progesterone receptor	PGR	0.0292
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.029
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0288
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0285
869	Estrogen receptor beta	ESR2	0.0283
844	Epidermal growth factor receptor	EGFR	0.0281
122	P2Y purinoceptor 12	P2RY12	0.028
33	Cystine/glutamate transporter	SLC7A11	0.0276
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0275
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0274
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0262
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0262
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0262
1517	Beta-3 adrenergic receptor	ADRB3	0.026
36	Insulin receptor	INSR	0.0258
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0255
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0253
504	Mast/stem cell growth factor receptor	KIT	0.0252
6010	Thiamine transporter 1	SLC19A2	0.0248
904	Glutathione S-transferase P	GSTP1	0.0243
6220	Aryl hydrocarbon receptor	AHR	0.0243
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0242
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.024
4203	Histamine N-methyltransferase	HNMT	0.0239
1010	Cytochrome P450 51A1	CYP51A1	0.0237
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0236
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0236
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0236
482	Glycine receptor subunit alpha-1	GLRA1	0.0235
811	Translocator protein	TSPO	0.0235
449	Ornithine decarboxylase	ODC1	0.0233
436	5-hydroxytryptamine 2B receptor	HTR2B	0.023
16	Adenosine A1 receptor	ADORA1	0.0227
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0227
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0225
175	Thiamin pyrophosphokinase 1	TPK1	0.0222
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0222
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0219
131	Synaptic vesicular amine transporter	SLC18A2	0.0219
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0218
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0217
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0217
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0217
163	D(1B) dopamine receptor	DRD5	0.0214
891	Dihydropteroate synthase	folP	0.0213
5359	Dihydropteroate synthase	folP	0.0213
7175	Dihydropteroate synthase	sulI	0.0213
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0211
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0211
3560	Gentamicin 3'-acetyltransferase	aacC1	0.021
1178	Adenosine A2a receptor	ADORA2A	0.021
2472	Voltage-gated potassium channel	kcsA	0.021
6366	Voltage-gated potassium channel	kcsA	0.021
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0209
70	Type-1 angiotensin II receptor	AGTR1	0.0206
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0206
2429	Putrescine-binding periplasmic protein	potF	0.0206
232	Corticosteroid-binding globulin	SERPINA6	0.0206
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0206
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0206
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0205
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0205
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0205
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0205
6102	Arylamine N-acetyltransferase 2	NAT2	0.0204
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0203
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0199
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0199
94	5-hydroxytryptamine 4 receptor	HTR4	0.0199
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0198
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0195
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0195
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0195
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0195
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0194
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0194
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0194
4120	NADPH--cytochrome P450 reductase	POR	0.0194
161	Tubulin beta chain	TUBB	0.0193
312	Tubulin beta chain	TUB2	0.0193
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0193
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0193
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0192
373	Transthyretin	TTR	0.0192
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0192
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0192
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0192
159	Penicillin-binding protein 2B	penA	0.0187
6121	Penicillin-binding protein 2B	penA	0.0187
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0187
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0187
4773	Deoxycytidine kinase	DCK	0.0186
244	Angiotensin-converting enzyme	ACE	0.0184
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0184
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0183
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0183
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0183
1268	Neuropeptide S receptor	NPSR1	0.0183
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0183
716	5-hydroxytryptamine 7 receptor	HTR7	0.0182
407	Vascular endothelial growth factor receptor 2	KDR	0.0181
26	Vascular endothelial growth factor receptor 3	FLT4	0.018
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0179
613	Atrial natriuretic peptide receptor A	NPR1	0.0179
624	Guanidinoacetate N-methyltransferase	GAMT	0.0178
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0178
6432	Transporter	snf	0.0174
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0174
150	Cationic amino acid transporter 3	SLC7A3	0.0173
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.0173
58	Cationic amino acid transporter 4	SLC7A4	0.0173
32	Vascular endothelial growth factor receptor 1	FLT1	0.0171
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0171
2449	Tubulin alpha-3 chain	TUBA1A	0.017
29	Tubulin beta-1 chain	TUBB1	0.0167
4122	Histone deacetylase 2	HDAC2	0.0167
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0166
818	50S ribosomal protein L10	rplJ	0.0165
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0164
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0163
5126	Arginase	rocF	0.0162
6164	POU domain, class 5, transcription factor 1	POU5F1	0.016
952	Dipeptidyl peptidase 4	DPP4	0.016
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.016
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.016
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0158
3810	Catechol O-methyltransferase	COMT	0.0158
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0156
1192	Sulfotransferase 1A1	SULT1A1	0.0156
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0156
6073	Potassium channel subfamily K member 9	KCNK9	0.0155
6072	Potassium channel subfamily K member 3	KCNK3	0.0155
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0154
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0154
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0153
365	Dihydrofolate reductase	DHFR	0.0151
2381	Dihydrofolate reductase	DFR1	0.0151
2833	Dihydrofolate reductase	Not Available	0.0151
2931	Dihydrofolate reductase	folA	0.0151
3544	Dihydrofolate reductase	folA	0.0151
3682	Dihydrofolate reductase	folA	0.0151
6642	Dihydrofolate reductase	folA	0.0151
6756	Dihydrofolate reductase	dfrA	0.0151
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.015
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.015
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0149
427	Substance-P receptor	TACR1	0.0149
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0148
6151	Monocarboxylate transporter 10	SLC16A10	0.0148
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0147
6085	Fatty acid-binding protein, intestinal	FABP2	0.0147
751	Potassium channel subfamily K member 6	KCNK6	0.0145
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0145
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0145
153	Dopamine beta-hydroxylase	DBH	0.0144
2499	Tubulin beta-2C chain	TUBB2C	0.0144
469	Annexin A1	ANXA1	0.0144
1656	CYP2B protein	CYP2B	0.0143
164	Histamine H4 receptor	HRH4	0.0143
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0143
723	Cytosolic phospholipase A2	PLA2G4A	0.0142
303	Diamine acetyltransferase 2	SAT2	0.0141
1317	Spermine synthase	SMS	0.0141
623	Spermine oxidase	SMOX	0.0141
705	Glutamate receptor 1	GRIA1	0.0141
291	Nitric-oxide synthase, endothelial	NOS3	0.0141
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.014
295	Carbonic anhydrase 1	CA1	0.014
633	Penicillin-binding proteins 1A/1B	pbpA	0.0139
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0139
6020	Aldehyde oxidase	AOX1	0.0138
4237	50S ribosomal protein L22	rplV	0.0138
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0137
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0136
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0136
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0136
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0136
571	Melatonin receptor type 1A	MTNR1A	0.0136
362	Melatonin receptor type 1B	MTNR1B	0.0136
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0136
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0136
6146	High affinity copper uptake protein 1	SLC31A1	0.0136
3587	Gastrotropin	FABP6	0.0135
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0134
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0133
172	Potassium channel subfamily K member 1	KCNK1	0.0133
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0132
4116	Dihydropteroate synthetase	Not Available	0.0131
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0129
3932	Glutathione S-transferase A2	GSTA2	0.0129
4238	50S ribosomal protein L4	rplD	0.0129
5578	50S ribosomal protein L4	rplD	0.0129
6173	50S ribosomal protein L4	rplD	0.0129
6219	50S ribosomal protein L4	rplD	0.0129
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0129
790	DNA polymerase subunit alpha B	POLA2	0.0129
828	Phenylalanine-4-hydroxylase	PAH	0.0128
3109	Phenylalanine-4-hydroxylase	phhA	0.0128
2300	Lysozyme	E	0.0128
3633	Lysozyme	R	0.0128
5597	Lysozyme	17	0.0128
273	Apoptosis regulator Bcl-2	BCL2	0.0127
123	Diamine acetyltransferase 1	SAT1	0.0127
2112	Toll-like receptor 9	TLR9	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0126
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
1629	Transcription factor AP-1	JUN	0.0125
823	Fibroblast growth factor receptor 2	FGFR2	0.0125
592	Carbonic anhydrase 4	CA4	0.0125
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0124
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0124
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0123
6167	Organic solute transporter subunit beta	OSTB	0.0123
6166	Organic solute transporter subunit alpha	OSTA	0.0123
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0123
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.012
528	5-hydroxytryptamine 1E receptor	HTR1E	0.012
1618	High affinity nerve growth factor receptor	NTRK1	0.0119
814	Ryanodine receptor 1	RYR1	0.0118
2207	Rhodopsin	RHO	0.0118
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0117
1341	Histamine H3 receptor	HRH3	0.0117
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0117
48	Pyridoxal kinase	PDXK	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0115
84	Nuclear receptor 0B1	NR0B1	0.0114
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0114
4311	tRNA	TRDMT1	0.0113
4325	tRNA	trmD	0.0113
4328	tRNA	trmD	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
6070	Nischarin	NISCH	0.0113
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0112
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0112
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0112
221	Lysyl-tRNA synthetase	KARS	0.0112
357	Carbonic anhydrase 2	CA2	0.0112
921	Glutamate receptor 2	GRIA2	0.0112
2539	Tubulin alpha-1 chain	TUBA4A	0.0112
1050	Bile salt sulfotransferase	SULT2A1	0.0111
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0111
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0111
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.011
908	Glutathione S-transferase theta-1	GSTT1	0.011
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0109
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0109
6149	Solute carrier family 22 member 10	SLC22A10	0.0109
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0108
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0107
6766	O-GlcNAcase BT_4395	BT_4395	0.0105
239	Coagulation factor X	F10	0.0105
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0105
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0105
1636	Trace amine-associated receptor 1	TAAR1	0.0104
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0103
275	Arachidonate 5-lipoxygenase	ALOX5	0.0103
558	Solute carrier family 12 member 1	SLC12A1	0.0102
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0101
1770	Phospholipase C	PLCL1	0.0101
2841	Phospholipase C	plc	0.0101
6044	Serum paraoxonase/lactonase 3	PON3	0.0101
165	FL cytokine receptor	FLT3	0.01
1830	5'-nucleotidase	NT5E	0.01
1360	Sphingomyelin phosphodiesterase	SMPD1	0.01
319	Opioid receptor, sigma 1	OPRS1	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
619	Low-affinity cationic amino acid transporter 2	SLC7A2	0.0098
694	Matrix protein 2	M	0.0098
594	Thyroxine-binding globulin	SERPINA7	0.0098
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0096
5300	Antigen peptide transporter 1	TAP1	0.0096
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
49	Endothelin B receptor	EDNRB	0.0096
88	Retinoic acid receptor RXR-beta	RXRB	0.0095
183	Vascular endothelial growth factor A	VEGFA	0.0095
3611	Cytidine deaminase	cdd	0.0095
3707	Cytidine deaminase	cdd	0.0095
4211	Cytidine deaminase	CDA	0.0095
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0094
284	DNA-directed RNA polymerase beta chain	rpoB	0.0094
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0094
6126	Carbonic anhydrase 7	CA7	0.0094
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0094
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0094
68	Cannabinoid receptor 1	CNR1	0.0092
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0092
5682	Ribonuclease pancreatic	RNASE1	0.0092
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0091
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0091
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0091
769	High-affinity choline transporter 1	SLC5A7	0.0091
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0091
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0091
3926	Choline transporter-like protein 2	SLC44A2	0.0091
1686	Choline transporter-like protein 1	SLC44A1	0.0091
861	Choline kinase alpha	CHKA	0.0091
3927	Choline transporter-like protein 3	SLC44A3	0.0091
700	Choline dehydrogenase, mitochondrial	CHDH	0.0091
3925	Choline transporter-like protein 4	SLC44A4	0.0091
576	Choline O-acetyltransferase	CHAT	0.0091
3922	Phospholipase D2	PLD2	0.0091
3924	Phospholipase D1	PLD1	0.0091
1852	Microtubule-associated protein 2	MAP2	0.0091
1630	Integrin beta-2	ITGB2	0.0091
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.009
758	Thyroid hormone receptor alpha	THRA	0.009
578	Endothelin-1 receptor	EDNRA	0.009
4228	Keratin, type II cytoskeletal 7	KRT7	0.009
6043	Putative G-protein coupled receptor 44	GPR44	0.0089
518	Peroxidase/catalase T	katG	0.0089
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0089
499	Arginine decarboxylase	ADC	0.0089
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0088
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
24	Thymidylate synthase	TMP1	0.0088
359	Thymidylate synthase	TYMS	0.0088
2626	Thymidylate synthase	thyA	0.0088
2729	Thymidylate synthase	thyA	0.0088
5352	Thymidylate synthase	THYA	0.0088
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0087
4192	DNA topoisomerase 2-beta	TOP2B	0.0087
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0087
3809	Estrogen-related receptor gamma	ESRRG	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
6218	Pannexin-1	PANX1	0.0086
6138	Multidrug resistance protein 3	ABCB4	0.0086
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
5934	Cytochrome P450 26A1	CYP26A1	0.0085
54	Prothrombin	F2	0.0085
577	Argininosuccinate lyase	ASL	0.0085
6168	Solute carrier family 22 member 16	SLC22A16	0.0084
834	Arginase-2, mitochondrial	ARG2	0.0084
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0084
6165	Copper-transporting ATPase 1	ATP7A	0.0084
6163	Copper-transporting ATPase 2	ATP7B	0.0084
174	Sigma 1-type opioid receptor	SIGMAR1	0.0084
820	Glycine receptor subunit alpha-2	GLRA2	0.0083
4103	Proteasome subunit beta type 2	PSMB2	0.0083
4102	Proteasome subunit beta type 5	PSMB5	0.0083
4101	Proteasome subunit beta type 1	PSMB1	0.0083
1	Peptidoglycan synthetase ftsI	ftsI	0.0083
4155	Peptidoglycan synthetase ftsI	ftsI	0.0083
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0082
527	Prostacyclin receptor	PTGIR	0.0082
780	Retinoic acid receptor RXR-gamma	RXRG	0.0082
444	Alcohol dehydrogenase 1B	ADH1B	0.0081
1483	Membrane copper amine oxidase	AOC3	0.0081
125	DNA polymerase beta	POLB	0.0081
1275	Estrogen sulfotransferase	SULT1E1	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
346	Thyroid hormone receptor beta-1	THRB	0.008
1864	RET proto-oncogene	RET	0.008
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.008
251	Alcohol dehydrogenase 1A	ADH1A	0.008
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.008
1353	DNA topoisomerase 1	TOP1	0.008
3552	DNA topoisomerase 1	topA	0.008
1196	Complement decay-accelerating factor	CD55	0.008
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.008
634	Squalene monooxygenase	SQLE	0.0079
7196	Squalene monooxygenase	ERG1	0.0079
645	Penicillin-binding protein 1A	mrcA	0.0079
5805	Penicillin-binding protein 1A	ponA	0.0079
6185	Penicillin-binding protein 1A	mrcA	0.0079
6799	Penicillin-binding protein 1A	pbpA	0.0079
3601	Dihydropteroate synthase 1	folP1	0.0079
3807	Dihydropteroate synthase 1	folP1	0.0079
3808	Dihydropteroate synthase 2	folP2	0.0079
6171	Solute carrier family 28 member 3	SLC28A3	0.0079
740	Argininosuccinate synthase	ASS1	0.0079
865	Argininosuccinate synthase	ASS1	0.0079
2680	Argininosuccinate synthase	argG	0.0079
3194	Argininosuccinate synthase	argG	0.0079
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0079
173	Toll-like receptor 7	TLR7	0.0079
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0078
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0078
867	Penicillin-binding protein 3	pbpC	0.0077
6119	Penicillin-binding protein 3	pbp3	0.0077
7154	Penicillin-binding protein 3	pbp3	0.0077
7157	Penicillin-binding protein 3	LMHCC_2184	0.0077
7162	Penicillin-binding protein 3	pbpB	0.0077
7172	Penicillin-binding protein 3	pbp3	0.0077
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0076
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0076
896	Glutathione S-transferase Mu 1	GSTM1	0.0075
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0075
1541	Metalloproteinase	mmp20	0.0074
856	Vitamin D3 receptor	VDR	0.0074
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0073
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0073
551	Carnitine O-acetyltransferase	CRAT	0.0073
5923	Microtubule-associated protein tau	MAPT	0.0071
5924	Microtubule-associated protein 4	MAP4	0.0071
6174	50S ribosomal protein L32	rpmF	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
1074	Urokinase-type plasminogen activator	PLAU	0.0071
517	Alcohol dehydrogenase 1C	ADH1C	0.007
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.007
162	Retinoic acid receptor gamma-1	RARG	0.007
581	Cytochrome P450 2R1	CYP2R1	0.007
2808	Chloramphenicol acetyltransferase 3	cat3	0.0069
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0069
572	Integrin alpha-L	ITGAL	0.0068
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0068
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0068
3086	Plasmepsin-2	Not Available	0.0068
563	Thyroid peroxidase	TPO	0.0068
106	Cannabinoid receptor 2	CNR2	0.0067
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0067
3913	Glutamic acid decarboxylase	GAD65	0.0066
3856	Fibroblast growth factor receptor 3	FGFR3	0.0066
489	Monocarboxylate transporter 2	SLC16A7	0.0064
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0064
860	Nicotinamide N-methyltransferase	NNMT	0.0064
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0064
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
699	Nicotinic acid receptor 1	GPR109A	0.0064
928	Nicotinic acid receptor 2	GPR109B	0.0064
1714	Mitogen-activated protein kinase 3	MAPK3	0.0064
3957	Adenosine deaminase	ADA	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
1648	Elastin	ELN	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0063
133	Dihydropterate synthase	sulI	0.0063
2810	Dr hemagglutinin structural subunit	draA	0.0062
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
199	Monocarboxylate transporter 8	SLC16A2	0.0062
3937	Fatty-acid amide hydrolase	FAAH	0.0061
1374	Natriuretic peptides B	NPPB	0.0061
1827	Gap junction alpha-1 protein	GJA1	0.0061
1291	cAMP response element-binding protein	CREB1	0.0061
1908	Vascular cell adhesion protein 1	VCAM1	0.0061
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0061
564	Cellular retinoic acid-binding protein 1	CRABP1	0.006
3917	Methylenetetrahydrofolate reductase	MTHFR	0.006
2981	Phospholipase A2, membrane associated	PLA2G2A	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
6033	High affinity interleukin-8 receptor A	CXCR1	0.0059
332	Beta-lactamase	blaZ	0.0059
2478	Beta-lactamase	ampC	0.0059
2613	Beta-lactamase	ampC	0.0059
2635	Beta-lactamase	ampC	0.0059
2700	Beta-lactamase	penP	0.0059
5445	Beta-lactamase	blaB	0.0059
6019	Beta-lactamase	SHV-7	0.0059
6701	Beta-lactamase	cphA	0.0059
4210	Toll-like receptor 4	TLR4	0.0059
4217	Telomerase reverse transcriptase	TERT	0.0059
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0058
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0058
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0058
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
6067	Penicillin binding protein 2a	mecA	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0058
936	Ephrin type-A receptor 2	EPHA2	0.0057
569	Retinal dehydrogenase 2	ALDH1A2	0.0057
788	Creatine kinase M-type	CKM	0.0057
5626	Nucleoside diphosphate kinase B	NME2	0.0056
1992	Vitamin D-binding protein	GC	0.0056
3904	Alanine aminotransferase 2	GPT2	0.0056
735	Alanine aminotransferase 1	GPT	0.0056
6506	Stathmin-4	STMN4	0.0055
461	Glycine receptor subunit alpha-3	GLRA3	0.0055
65	Matrix metalloproteinase-9	Not Available	0.0054
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
268	Adenosine A2b receptor	ADORA2B	0.0054
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0053
611	Retinal dehydrogenase 1	ALDH1A1	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
702	UMP-CMP kinase	CMPK1	0.0053
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0052
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0052
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
719	Retinoic acid receptor responder protein 1	RARRES1	0.0052
770	Retinoic acid-induced protein 3	GPRC5A	0.0052
712	Tubulin alpha chain	TUB1	0.0052
3426	Glutamine synthetase	glnA	0.0052
3987	Glutamine synthetase	GLUL	0.0052
6211	Tubulin epsilon chain	TUBE1	0.0052
6212	Tubulin gamma-1 chain	TUBG1	0.0052
6210	Tubulin delta chain	TUBD1	0.0052
267	Plasminogen activator inhibitor 1	SERPINE1	0.0052
3090	Chitosanase	csn	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
5787	Angiopoietin-1 receptor	TEK	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
342	P protein [Includes: DNA-directed DNA polymerase	P	0.005
612	P protein [Includes: DNA-directed DNA polymerase	P	0.005
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.005
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
6048	Troponin C, skeletal muscle	TNNC2	0.005
3404	Exotoxin A	eta	0.0049
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0048
1039	Histone deacetylase 9	HDAC9	0.0048
1176	Mitogen-activated protein kinase 1	MAPK1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1525	Heparin-binding growth factor 2	FGF2	0.0046
1253	Interferon gamma	IFNG	0.0046
6221	Steroid hormone receptor ERR1	ESRRA	0.0046
2230	Catalase	CAT	0.0046
3249	Catalase	katA	0.0046
3625	Catalase	katA	0.0046
4539	Catalase	katA	0.0046
4941	Catalase	katB	0.0046
2236	Casein kinase II subunit alpha	CSNK2A1	0.0046
2320	Thymidine kinase, cytosolic	TK1	0.0045
5294	Nucleoside diphosphate kinase A	NME1	0.0045
6824	Tyrosine-protein kinase Lyn	LYN	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0045
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0044
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0044
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0044
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0044
2021	Thrombomodulin	THBD	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
3830	Calreticulin	CALR	0.0043
117	Sterol O-acyltransferase 1	SOAT1	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0042
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0042
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0041
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
1650	Heme carrier protein 1	SLC46A1	0.0041
6034	Hydroxyindole O-methyltransferase	ASMT	0.0041
6035	Nuclear receptor ROR-beta	RORB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6036	Eosinophil peroxidase	EPX	0.0041
730	Retinoic acid receptor alpha	RARA	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.004
500	Monocarboxylate transporter 4	SLC16A3	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
484	Tyrosine-protein kinase ABL2	ABL2	0.0039
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0039
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0038
1569	G1/S-specific cyclin-D1	CCND1	0.0038
85	Growth hormone receptor	GHR	0.0038
400	Coagulation factor IX	F9	0.0037
5461	Coagulation factor IX	F9	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0036
6131	Carbonic anhydrase 14	CA14	0.0036
2216	Fibroblast growth factor receptor 4	FGFR4	0.0035
765	Indoleamine 2,3-dioxygenase	IDO1	0.0035
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0035
1262	Corticotropin-lipotropin	POMC	0.0035
939	50S ribosomal protein L3	rplC	0.0035
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0034
604	Vitamin K-dependent protein Z	PROZ	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0034
6122	Carbonic anhydrase 3	CA3	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
277	Purine nucleoside phosphorylase	PNP	0.0033
2870	Purine nucleoside phosphorylase	punA	0.0033
2945	Purine nucleoside phosphorylase	punA	0.0033
4659	Purine nucleoside phosphorylase	TM_1596	0.0033
4825	Purine nucleoside phosphorylase	TTHA1435	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0032
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0032
293	Gamma-glutamyl hydrolase	GGH	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
422	Vitamin K-dependent protein C	PROC	0.0031
1245	Vitamin K-dependent protein S	PROS1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3639	Thymidine phosphorylase	deoA	0.003
3936	Thymidine phosphorylase	TYMP	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
1792	Tissue-type plasminogen activator	PLAT	0.003
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.003
2599	Tyrosine-protein kinase HCK	HCK	0.003
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0029
2298	Cytochrome P450-cam	camC	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
663	Solute carrier family 12 member 4	SLC12A4	0.0029
53	Solute carrier family 12 member 5	SLC12A5	0.0029
6459	Glycodelin	PAEP	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
5798	Mitogen-activated protein kinase 11	MAPK11	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6042	Prostaglandin reductase 2	PTGR2	0.0027
310	Solute carrier family 12 member 2	SLC12A2	0.0027
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
2408	Tyrosine-protein kinase SYK	SYK	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6859	Protein S100-A4	S100A4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
798	Osteocalcin	BGLAP	0.0025
358	Cystathionine beta-synthase	CBS	0.0025
3007	Carbonic anhydrase 12	CA12	0.0025
4205	Carbonic anhydrase 9	CA9	0.0025
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
760	Fibroblast growth factor 1	FGF1	0.0024
4226	Uridine phosphorylase 2	UPP2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0023
369	Coagulation factor VII	F7	0.0023
822	Aldose reductase	AKR1B1	0.0023
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0023
707	72 kDa type IV collagenase	MMP2	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
997	Protein kinase C beta type	PRKCB	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
4225	Uridine phosphorylase 1	UPP1	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
3221	Cytochrome c4	cc4	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.002
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.002
1313	Lactoylglutathione lyase	GLO1	0.002
413	Amidophosphoribosyltransferase	PPAT	0.002
2515	Amidophosphoribosyltransferase	purF	0.002
3714	Amidophosphoribosyltransferase	purF	0.002
1970	Protein kinase C alpha type	PRKCA	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
5818	Folate receptor alpha	FOLR1	0.0017
2391	Ferrochelatase	hemH	0.0017
6502	Ferrochelatase	DKFZp686P18130	0.0017
1591	Ferrochelatase, mitochondrial	FECH	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0016
6837	Serine/threonine-protein kinase 17B	STK17B	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
1243	Cathepsin D	CTSD	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
6677	Myelin P2 protein	PMP2	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0015
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0015
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0015
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0015
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0015
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0015
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0015
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0015
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0015
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0015
6559	Cytochrome c oxidase subunit 2	ctaC	0.0015
6669	Cytochrome c oxidase subunit 2	ctaC	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0015
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0015
6558	Cytochrome c oxidase subunit 1	ctaD	0.0015
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0014
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
2540	Choloylglycine hydrolase	cbh	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0013
6501	Fatty acid-binding protein, liver	FABP1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
4692	A/G-specific adenine glycosylase	mutY	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0012
1295	Fatty acid synthase	FASN	0.0012
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0012
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0012
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
2802	Endoglucanase G	celCCG	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
6500	Phospholipase A2	PLA2G1B	0.0011
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.001
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0009
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0009
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0009
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2132	Protein S100-B	S100B	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
76	Nitric-oxide synthase, brain	NOS1	0.0008
1867	Major prion protein	PRNP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1507	Cytochrome c	CYCS	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4916	Cyanoglobin	glbN	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4943	Cytochrome c6	petJ	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
5000	HemO	hemO	0.0005
4984	Neuroglobin	NGB	0.0005
4909	CooA protein	cooA	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4910	Cytoglobin	CYGB	0.0005
4961	Hemophore HasA	hasA	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4972	P450cin	cinA	0.0005
4952	Catalase/peroxidase	katA	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00468 - Quinine

Targets

Enzymes

Transporters

Predictions