DT-Web

DB00531 - Cyclophosphamide


Identification
Name Cyclophosphamide
Accession Number DB00531 (APRD00408)
Type small molecule
Description Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 261.086
Groups approved
Monoisotopic Weight 260.02481966
Pharmacology
Indication Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.
Mechanism of action Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Absorption After oral administration, peak concentrations occur at one hour.
Protein binding 20% of cyclophosphamide is protein bound with no dose dependent changes. Some metabolites are protein bound to an extent greater than 60%.
Biotransformation Metabolism and activation occurs at the liver. 75% of the drug is activated by cytochrome P450 isoforms, CYP2A6, 2B6, 3A4, 3A5, 2C9, 2C18, and 2C19. The CYP2B6 isoform is the enzyme with the highest 4-hydroxylase activity. Cyclophosphamide undergoes activation to eventually form active metabolites, phosphoramide mustard and acrolein. Cyclophosphamide appears to induce its own metabolism which results in an overall increase in clearance, increased formation of 4-hydroxyl metabolites, and shortened t1/2 values following repeated administration.
Route of elimination Cyclophosphamide is eliminated primarily in the form of metabolites. 10-20% is excreted unchanged in the urine and 4% is excreted in the bile following IV administration.
Toxicity Adverse reactions reported most often include neutropenia, febrile neutropenia, fever, alopecia, nausea, vomiting, and diarrhea.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The antineoplastic agent, cyclophosphamide may alter the anticoagulant effect of acenocoumarol.
Anisindione The antineoplastic agent, cyclophosphamide may alter the anticoagulant effect of anisindione.
Bendamustine Increases toxicity through pharmacodynamic synergism. Additive myelosuppression.
Dicumarol The antineoplastic agent, cyclophosphamide may alter the anticoagulant effect of dicumarol.
Digoxin The antineoplasic agent decreases the effect of digoxin
Fluconazole Fluconazole reduces metabolism and clearance of cyclophosphamide.
Pentostatin Increased toxicity of cyclophosphamide
Succinylcholine Cyclophosphamide may increase the effect of succinylcholine.
Thiotepa Thiotepa, a strong CYP2B6 inhibitor, may decrease the metabolism and clearance of Cyclophosphamide, a CYP2B6 substrate. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Cyclophosphamide if Thiotepa is initiated, discontinued or dose changed.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Warfarin The antineoplastic agent, cyclophosphamide may alter the anticoagulant effect of warfarin.
Food Interactions
  • Drink liberally- 2 to 3 liters/day.
  • Take with food to reduce irritation.

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions cross-linking/alkylation
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Khan O, Middleton MR: The therapeutic potential of O6-alkylguanine DNA alkyltransferase inhibitors. Expert Opin Investig Drugs. 2007 Oct;16(10):1573-84. - Pubmed
  • Schmidt E, Tony HP, Brocker EB, Kneitz C: Sun-induced life-threatening lupus nephritis. Ann N Y Acad Sci. 2007 Jun;1108:35-40. - Pubmed
  • Zhang QH, Wu CF, Duan L, Yang JY: Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells. Food Chem Toxicol. 2007 Aug 23;. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6711
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preiss R, Schmidt R, Baumann F, Hanschmann H, Hauss J, Geissler F, Pahlig H, Ratzewiss B: Measurement of 4-hydroxylation of ifosfamide in human liver microsomes using the estimation of free and protein-bound acrolein and codetermination of keto- and carboxyifosfamide. J Cancer Res Clin Oncol. 2002 Jul;128(7):385-92. Epub 2002 Jun 11. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9323
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preiss R, Schmidt R, Baumann F, Hanschmann H, Hauss J, Geissler F, Pahlig H, Ratzewiss B: Measurement of 4-hydroxylation of ifosfamide in human liver microsomes using the estimation of free and protein-bound acrolein and codetermination of keto- and carboxyifosfamide. J Cancer Res Clin Oncol. 2002 Jul;128(7):385-92. Epub 2002 Jun 11. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4374
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5968
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3771
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2515
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5072
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6482
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4081
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Ekhart C, Doodeman VD, Rodenhuis S, Smits PH, Beijnen JH, Huitema AD: Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide. Pharmacogenet Genomics. 2008 Jun;18(6):515-23. doi: 10.1097/FPC.0b013e3282fc9766. - Pubmed
DTHybrid score 0.5161

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. - Pubmed
DTHybrid score 0.5486

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.3968
6013 Cytochrome P450 2E1 CYP2E1 0.2399
6024 Cytochrome P450 1A1 CYP1A1 0.1789
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1398
587 Serum albumin ALB 0.1392
20 Prostaglandin G/H synthase 1 PTGS1 0.1357
492 Histamine H1 receptor HRH1 0.1029
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1024
824 Sodium-dependent serotonin transporter SLC6A4 0.0973
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0945
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.09
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0885
862 Multidrug resistance-associated protein 1 ABCC1 0.0834
1729 Solute carrier family 22 member 6 SLC22A6 0.0727
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0726
3811 Cytochrome P450 19A1 CYP19A1 0.0722
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0712
6145 Solute carrier family 22 member 1 SLC22A1 0.0702
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0676
1898 Cytochrome P450 1B1 CYP1B1 0.0675
831 D(2) dopamine receptor DRD2 0.0671
502 5-hydroxytryptamine 2A receptor HTR2A 0.0665
847 Mu-type opioid receptor OPRM1 0.0653
6144 Solute carrier family 22 member 2 SLC22A2 0.0632
556 Alpha-1A adrenergic receptor ADRA1A 0.0629
290 Prostaglandin G/H synthase 2 PTGS2 0.0607
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0587
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0586
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0583
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0582
776 Bile salt export pump ABCB11 0.0577
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.055
766 Beta-2 adrenergic receptor ADRB2 0.0547
320 5-hydroxytryptamine 1A receptor HTR1A 0.0534
118 Organic cation/carnitine transporter 2 SLC22A5 0.0527
6031 Cytochrome P450 3A43 CYP3A43 0.0525
467 Delta-type opioid receptor OPRD1 0.0516
468 Cytochrome P450 4A11 CYP4A11 0.0504
713 Sodium-dependent dopamine transporter SLC6A3 0.0501
51 Muscarinic acetylcholine receptor M3 CHRM3 0.05
871 Glucocorticoid receptor NR3C1 0.0486
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0468
731 HIV-1 protease HIV-1 protease 0.0466
696 Kappa-type opioid receptor OPRK1 0.0465
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0454
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0454
136 Estrogen receptor ESR1 0.0453
617 Muscarinic acetylcholine receptor M2 CHRM2 0.045
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0441
590 5-hydroxytryptamine 2C receptor HTR2C 0.0434
260 Cytochrome P450 51 ERG11 0.0431
761 Cytochrome P450 51 ERG11 0.0431
3163 Cytochrome P450 51 cyp51 0.0431
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0428
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0423
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0421
6143 Solute carrier family 22 member 7 SLC22A7 0.0413
318 Alpha-2A adrenergic receptor ADRA2A 0.041
2164 Multidrug resistance-associated protein 4 ABCC4 0.0406
6142 Solute carrier family 22 member 8 SLC22A8 0.0405
193 Beta-1 adrenergic receptor ADRB1 0.04
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0396
23 D(1A) dopamine receptor DRD1 0.0394
465 Calmodulin CALM1 0.0389
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0386
341 5-hydroxytryptamine 3 receptor HTR3A 0.0386
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0386
632 Alpha-1B adrenergic receptor ADRA1B 0.0381
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0379
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0378
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0369
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0368
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0365
6147 Solute carrier family 22 member 3 SLC22A3 0.0362
3941 Amine oxidase [flavin-containing] A MAOA 0.0345
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.034
6182 Cytochrome P450 2J2 CYP2J2 0.0336
638 D(3) dopamine receptor DRD3 0.0316
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0313
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0305
833 Organic cation/carnitine transporter 1 SLC22A4 0.0298
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0298
3923 Cholinesterase BCHE 0.0297
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0293
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0293
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0293
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.029
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.029
817 DNA topoisomerase 2-alpha TOP2A 0.029
122 P2Y purinoceptor 12 P2RY12 0.0288
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0282
3939 Amine oxidase [flavin-containing] B MAOB 0.0281
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0272
844 Epidermal growth factor receptor EGFR 0.0272
614 Progesterone receptor PGR 0.0269
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0269
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0266
885 5-hydroxytryptamine 1B receptor HTR1B 0.0261
380 Cytochrome P450 17A1 CYP17A1 0.0258
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0256
891 Dihydropteroate synthase folP 0.0251
5359 Dihydropteroate synthase folP 0.0251
7175 Dihydropteroate synthase sulI 0.0251
146 Androgen receptor AR 0.0251
6148 Multidrug resistance-associated protein 7 ABCC10 0.025
789 Alpha-1D adrenergic receptor ADRA1D 0.0246
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0243
811 Translocator protein TSPO 0.024
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0237
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0234
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0234
6102 Arylamine N-acetyltransferase 2 NAT2 0.0233
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0233
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0233
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0233
504 Mast/stem cell growth factor receptor KIT 0.0229
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0227
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0225
6136 Multidrug resistance-associated protein 5 ABCC5 0.0224
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0224
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0224
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0224
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0224
737 Mineralocorticoid receptor NR3C2 0.0221
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0221
4604 Liver carboxylesterase 1 CES1 0.022
725 5-hydroxytryptamine 1D receptor HTR1D 0.0218
6014 Cytochrome P450 2A13 CYP2A13 0.0215
1024 Solute carrier family 22 member 11 SLC22A11 0.0213
4120 NADPH--cytochrome P450 reductase POR 0.0213
629 Alpha-2B adrenergic receptor ADRA2B 0.0212
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0211
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0211
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0203
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
756 Sex hormone-binding globulin SHBG 0.0202
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0201
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0201
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0199
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0199
232 Corticosteroid-binding globulin SERPINA6 0.0198
378 Alpha-2C adrenergic receptor ADRA2C 0.0196
70 Type-1 angiotensin II receptor AGTR1 0.0191
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0191
6137 Multidrug resistance-associated protein 6 ABCC6 0.0191
432 D(4) dopamine receptor DRD4 0.019
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0188
6141 Sodium/bile acid cotransporter SLC10A1 0.0187
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0186
124 Histamine H2 receptor HRH2 0.0184
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0183
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0181
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0181
716 5-hydroxytryptamine 7 receptor HTR7 0.0181
869 Estrogen receptor beta ESR2 0.0179
1010 Cytochrome P450 51A1 CYP51A1 0.0176
407 Vascular endothelial growth factor receptor 2 KDR 0.0176
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0176
436 5-hydroxytryptamine 2B receptor HTR2B 0.0176
26 Vascular endothelial growth factor receptor 3 FLT4 0.0173
94 5-hydroxytryptamine 4 receptor HTR4 0.0173
161 Tubulin beta chain TUBB 0.0172
312 Tubulin beta chain TUB2 0.0172
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0168
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0168
818 50S ribosomal protein L10 rplJ 0.0167
29 Tubulin beta-1 chain TUBB1 0.0167
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0166
32 Vascular endothelial growth factor receptor 1 FLT1 0.0165
6174 50S ribosomal protein L32 rpmF 0.0165
6220 Aryl hydrocarbon receptor AHR 0.0163
228 Beta platelet-derived growth factor receptor PDGFRB 0.0163
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0161
1656 CYP2B protein CYP2B 0.016
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0159
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0159
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0158
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0158
85 Growth hormone receptor GHR 0.0156
705 Glutamate receptor 1 GRIA1 0.0156
952 Dipeptidyl peptidase 4 DPP4 0.0156
427 Substance-P receptor TACR1 0.0154
4237 50S ribosomal protein L22 rplV 0.015
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0149
777 Tumor necrosis factor TNF 0.0146
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0146
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0145
482 Glycine receptor subunit alpha-1 GLRA1 0.0144
84 Nuclear receptor 0B1 NR0B1 0.0144
174 Sigma 1-type opioid receptor SIGMAR1 0.0143
4238 50S ribosomal protein L4 rplD 0.0142
5578 50S ribosomal protein L4 rplD 0.0142
6173 50S ribosomal protein L4 rplD 0.0142
6219 50S ribosomal protein L4 rplD 0.0142
1192 Sulfotransferase 1A1 SULT1A1 0.0141
1757 Myeloperoxidase MPO 0.0137
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0137
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0137
474 Acetylcholinesterase ACHE 0.0137
131 Synaptic vesicular amine transporter SLC18A2 0.0136
373 Transthyretin TTR 0.0134
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0134
738 Monocarboxylate transporter 1 SLC16A1 0.0134
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0133
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0131
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0129
477 DNA topoisomerase 4 subunit A parC 0.0129
886 DNA topoisomerase 4 subunit A parC 0.0129
6226 DNA topoisomerase 4 subunit A parC 0.0129
275 Arachidonate 5-lipoxygenase ALOX5 0.0128
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0127
404 DNA gyrase subunit A gyrA 0.0127
6224 DNA gyrase subunit A gyrA 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0126
528 5-hydroxytryptamine 1E receptor HTR1E 0.0126
921 Glutamate receptor 2 GRIA2 0.0126
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0126
6020 Aldehyde oxidase AOX1 0.0124
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0123
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.012
365 Dihydrofolate reductase DHFR 0.0119
2381 Dihydrofolate reductase DFR1 0.0119
2833 Dihydrofolate reductase Not Available 0.0119
2931 Dihydrofolate reductase folA 0.0119
3544 Dihydrofolate reductase folA 0.0119
3682 Dihydrofolate reductase folA 0.0119
6642 Dihydrofolate reductase folA 0.0119
6756 Dihydrofolate reductase dfrA 0.0119
88 Retinoic acid receptor RXR-beta RXRB 0.0119
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0117
295 Carbonic anhydrase 1 CA1 0.0117
537 ATP synthase delta chain, mitochondrial ATP5D 0.0116
1256 5-hydroxytryptamine 6 receptor HTR6 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
163 D(1B) dopamine receptor DRD5 0.0114
6432 Transporter snf 0.0114
3808 Dihydropteroate synthase 2 folP2 0.0113
3601 Dihydropteroate synthase 1 folP1 0.0113
3807 Dihydropteroate synthase 1 folP1 0.0113
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0113
2539 Tubulin alpha-1 chain TUBA4A 0.0112
3932 Glutathione S-transferase A2 GSTA2 0.0111
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0111
6085 Fatty acid-binding protein, intestinal FABP2 0.011
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0109
780 Retinoic acid receptor RXR-gamma RXRG 0.0107
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0107
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0106
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0105
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0104
469 Annexin A1 ANXA1 0.0104
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0104
165 FL cytokine receptor FLT3 0.0104
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0102
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0101
319 Opioid receptor, sigma 1 OPRS1 0.0101
719 Retinoic acid receptor responder protein 1 RARRES1 0.01
770 Retinoic acid-induced protein 3 GPRC5A 0.01
1050 Bile salt sulfotransferase SULT2A1 0.01
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.01
768 FK506-binding protein 1A FKBP1A 0.01
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0099
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0099
4116 Dihydropteroate synthetase Not Available 0.0097
68 Cannabinoid receptor 1 CNR1 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
518 Peroxidase/catalase T katG 0.0096
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0096
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0096
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0096
4203 Histamine N-methyltransferase HNMT 0.0096
5300 Antigen peptide transporter 1 TAP1 0.0096
49 Endothelin B receptor EDNRB 0.0096
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0095
162 Retinoic acid receptor gamma-1 RARG 0.0092
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0092
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0092
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0091
3947 Xanthine dehydrogenase/oxidase XDH 0.0091
1618 High affinity nerve growth factor receptor NTRK1 0.0091
1852 Microtubule-associated protein 2 MAP2 0.0091
3810 Catechol O-methyltransferase COMT 0.0091
239 Coagulation factor X F10 0.009
578 Endothelin-1 receptor EDNRA 0.009
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.009
1353 DNA topoisomerase 1 TOP1 0.0089
3552 DNA topoisomerase 1 topA 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0088
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0088
569 Retinal dehydrogenase 2 ALDH1A2 0.0087
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0087
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0087
24 Thymidylate synthase TMP1 0.0087
359 Thymidylate synthase TYMS 0.0087
2626 Thymidylate synthase thyA 0.0087
2729 Thymidylate synthase thyA 0.0087
5352 Thymidylate synthase THYA 0.0087
6138 Multidrug resistance protein 3 ABCB4 0.0086
563 Thyroid peroxidase TPO 0.0085
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0085
1178 Adenosine A2a receptor ADORA2A 0.0085
823 Fibroblast growth factor receptor 2 FGFR2 0.0085
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0085
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
3809 Estrogen-related receptor gamma ESRRG 0.0084
814 Ryanodine receptor 1 RYR1 0.0083
611 Retinal dehydrogenase 1 ALDH1A1 0.0082
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0081
273 Apoptosis regulator Bcl-2 BCL2 0.0081
1196 Complement decay-accelerating factor CD55 0.008
1630 Integrin beta-2 ITGB2 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0079
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0079
3426 Glutamine synthetase glnA 0.0079
3987 Glutamine synthetase GLUL 0.0079
54 Prothrombin F2 0.0079
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0078
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
2230 Catalase CAT 0.0078
3249 Catalase katA 0.0078
3625 Catalase katA 0.0078
4539 Catalase katA 0.0078
4941 Catalase katB 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0076
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0076
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0075
1541 Metalloproteinase mmp20 0.0074
1039 Histone deacetylase 9 HDAC9 0.0074
251 Alcohol dehydrogenase 1A ADH1A 0.0074
284 DNA-directed RNA polymerase beta chain rpoB 0.0074
5773 DNA-directed RNA polymerase beta chain rpoB 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
7 Nitric oxide synthase, inducible NOS2 0.0073
4122 Histone deacetylase 2 HDAC2 0.0073
357 Carbonic anhydrase 2 CA2 0.0072
106 Cannabinoid receptor 2 CNR2 0.0072
5923 Microtubule-associated protein tau MAPT 0.0071
5924 Microtubule-associated protein 4 MAP4 0.0071
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0071
856 Vitamin D3 receptor VDR 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
1629 Transcription factor AP-1 JUN 0.007
3937 Fatty-acid amide hydrolase FAAH 0.007
444 Alcohol dehydrogenase 1B ADH1B 0.0069
2808 Chloramphenicol acetyltransferase 3 cat3 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
1275 Estrogen sulfotransferase SULT1E1 0.0068
16 Adenosine A1 receptor ADORA1 0.0068
3086 Plasmepsin-2 Not Available 0.0068
1483 Membrane copper amine oxidase AOC3 0.0067
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
4311 tRNA TRDMT1 0.0067
4325 tRNA trmD 0.0067
4328 tRNA trmD 0.0067
183 Vascular endothelial growth factor A VEGFA 0.0066
976 Platelet glycoprotein IX GP9 0.0066
5934 Cytochrome P450 26A1 CYP26A1 0.0066
581 Cytochrome P450 2R1 CYP2R1 0.0065
1517 Beta-3 adrenergic receptor ADRB3 0.0065
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0064
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0064
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0064
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1360 Sphingomyelin phosphodiesterase SMPD1 0.0063
133 Dihydropterate synthase sulI 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
2449 Tubulin alpha-3 chain TUBA1A 0.0062
4773 Deoxycytidine kinase DCK 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0061
153 Dopamine beta-hydroxylase DBH 0.0061
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.006
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6126 Carbonic anhydrase 7 CA7 0.006
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0059
517 Alcohol dehydrogenase 1C ADH1C 0.0059
5787 Angiopoietin-1 receptor TEK 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
4103 Proteasome subunit beta type 2 PSMB2 0.0059
4102 Proteasome subunit beta type 5 PSMB5 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0059
4101 Proteasome subunit beta type 1 PSMB1 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
3856 Fibroblast growth factor receptor 3 FGFR3 0.0058
511 5-hydroxytryptamine 1F receptor HTR1F 0.0058
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0058
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0058
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0057
2981 Phospholipase A2, membrane associated PLA2G2A 0.0056
904 Glutathione S-transferase P GSTP1 0.0056
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0056
6506 Stathmin-4 STMN4 0.0055
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0054
558 Solute carrier family 12 member 1 SLC12A1 0.0054
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0054
6044 Serum paraoxonase/lactonase 3 PON3 0.0054
4217 Telomerase reverse transcriptase TERT 0.0053
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
1992 Vitamin D-binding protein GC 0.0052
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0052
3913 Glutamic acid decarboxylase GAD65 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.005
572 Integrin alpha-L ITGAL 0.005
6048 Troponin C, skeletal muscle TNNC2 0.005
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0049
267 Plasminogen activator inhibitor 1 SERPINE1 0.0049
173 Toll-like receptor 7 TLR7 0.0049
634 Squalene monooxygenase SQLE 0.0049
7196 Squalene monooxygenase ERG1 0.0049
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0048
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0048
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
1648 Elastin ELN 0.0046
164 Histamine H4 receptor HRH4 0.0046
936 Ephrin type-A receptor 2 EPHA2 0.0046
527 Prostacyclin receptor PTGIR 0.0045
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0045
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0045
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0045
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0045
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0045
6824 Tyrosine-protein kinase Lyn LYN 0.0045
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0045
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0045
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0045
2298 Cytochrome P450-cam camC 0.0045
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0044
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0044
6221 Steroid hormone receptor ERR1 ESRRA 0.0044
130 Prostacyclin synthase PTGIS 0.0044
3904 Alanine aminotransferase 2 GPT2 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
2320 Thymidine kinase, cytosolic TK1 0.0042
6043 Putative G-protein coupled receptor 44 GPR44 0.0041
1864 RET proto-oncogene RET 0.0041
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0041
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0041
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6149 Solute carrier family 22 member 10 SLC22A10 0.004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
751 Potassium channel subfamily K member 6 KCNK6 0.0039
3639 Thymidine phosphorylase deoA 0.0039
3936 Thymidine phosphorylase TYMP 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0038
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0038
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
291 Nitric-oxide synthase, endothelial NOS3 0.0038
33 Cystine/glutamate transporter SLC7A11 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0037
5798 Mitogen-activated protein kinase 11 MAPK11 0.0037
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
4192 DNA topoisomerase 2-beta TOP2B 0.0037
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0037
3917 Methylenetetrahydrofolate reductase MTHFR 0.0036
2207 Rhodopsin RHO 0.0036
172 Potassium channel subfamily K member 1 KCNK1 0.0036
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
4226 Uridine phosphorylase 2 UPP2 0.0035
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0035
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0035
1268 Neuropeptide S receptor NPSR1 0.0035
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0034
758 Thyroid hormone receptor alpha THRA 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
908 Glutathione S-transferase theta-1 GSTT1 0.0034
605 Fumarate reductase flavoprotein subunit frdA 0.0034
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0034
3673 Fumarate reductase flavoprotein subunit fccA 0.0034
4912 Fumarate reductase flavoprotein subunit ifcA 0.0034
6549 Fumarate reductase flavoprotein subunit frdA 0.0034
5880 Thrombopoietin receptor MPL 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
4225 Uridine phosphorylase 1 UPP1 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
6073 Potassium channel subfamily K member 9 KCNK9 0.0032
6072 Potassium channel subfamily K member 3 KCNK3 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
413 Amidophosphoribosyltransferase PPAT 0.003
2515 Amidophosphoribosyltransferase purF 0.003
3714 Amidophosphoribosyltransferase purF 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
992 Protein tyrosine kinase 2 beta PTK2B 0.0026
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
489 Monocarboxylate transporter 2 SLC16A7 0.0025
3957 Adenosine deaminase ADA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6218 Pannexin-1 PANX1 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1374 Natriuretic peptides B NPPB 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
1341 Histamine H3 receptor HRH3 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
707 72 kDa type IV collagenase MMP2 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.002
1063 Signal transducer and activator of transcription 5B STAT5B 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
896 Glutathione S-transferase Mu 1 GSTM1 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.002
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
400 Coagulation factor IX F9 0.002
5461 Coagulation factor IX F9 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
3221 Cytochrome c4 cc4 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
4948 Cytochrome c-553 Not Available 0.0019
4923 Cytochrome c3 DvMF_2499 0.0019
4945 Cytochrome c3 Not Available 0.0019
4949 Cytochrome c3 DVU_3171 0.0019
4968 Cytochrome c3 cytc3 0.0019
4997 Cytochrome c3 SO_2727 0.0019
5219 Cytochrome c3 cyd 0.0019
4902 Nine-heme cytochrome c Ddes_2038 0.0019
3189 High-molecular-weight cytochrome c hmcA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0018
604 Vitamin K-dependent protein Z PROZ 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
4954 Soluble cytochrome b558 Not Available 0.0018
4925 Cytochrome c-type protein SHP shp 0.0018
4934 Cytochrome c-551 nirM 0.0018
5218 Cytochrome c-551 nirM 0.0018
4915 Cytochrome c-550 psbV 0.0018
4959 Cytochrome c-550 psbV 0.0018
5216 Cytochrome c-550 psbV 0.0018
4905 Cytochrome c2 Not Available 0.0018
4939 Cytochrome c2 cycA 0.0018
4964 Cytochrome c2 cycA 0.0018
4979 Cytochrome c2 cycA 0.0018
6673 Cytochrome c2 cycA 0.0018
4947 Bacterial hemoglobin vhb 0.0018
4975 Cytochrome c-556 RPA3973 0.0018
4916 Cyanoglobin glbN 0.0018
4943 Cytochrome c6 petJ 0.0018
4998 Hemoglobin-like protein yjbI yjbI 0.0018
4984 Neuroglobin NGB 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
4936 Cytochrome c2 iso-2 Not Available 0.0018
4994 Hemoglobin-like protein HbO glbO 0.0018
4907 Cytochrome c-L moxG 0.0018
6865 Cytochrome c-L moxG 0.0018
4909 CooA protein cooA 0.0018
644 Heme oxygenase 2 HMOX2 0.0018
4982 Heme oxygenase 2 pbsA2 0.0018
4942 Diheme cytochrome c napB napB 0.0018
4910 Cytoglobin CYGB 0.0018
4981 Iron-starvation protein PigA pigA 0.0018
4935 Cytochrome c-554 cycA1 0.0018
5000 HemO hemO 0.0018
4961 Hemophore HasA hasA 0.0018
4971 Nonaheme cytochrome c hmcA 0.0018
4904 Cytochrome c family protein GSU1996 0.0018
76 Nitric-oxide synthase, brain NOS1 0.0018
4976 Apocytochrome f petA 0.0018
6407 Apocytochrome f petA 0.0018
4989 Cytochrome c551 peroxidase ccp 0.0018
5222 Cytochrome c551 peroxidase ccpA 0.0018
4999 Cytochrome P450 165B3 CYP165B3 0.0018
4764 Cytochrome P450 165C4 CYP165C4 0.0018
4960 Putative cytochrome P450-family protein SCO7417 0.0018
4931 Cytochrome P450 167A1 CYP167A1 0.0018
4926 Heme-based aerotactic transducer hemAT hemAT 0.0018
4937 Cytochrome oxidase subunit II rcoxA 0.0018
4903 Methyl-accepting chemotaxis protein Tar4 0.0018
4993 Hydroxylamine oxidoreductase hao1 0.0018
4972 P450cin cinA 0.0018
4922 Cytochrome c, putative SO_4144 0.0018
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0018
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0018
3093 Catalase HPII katE 0.0018
4952 Catalase/peroxidase katA 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
3830 Calreticulin CALR 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
6168 Solute carrier family 22 member 16 SLC22A16 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
4386 Hemoglobin-like protein HbN glbN 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
6163 Copper-transporting ATPase 2 ATP7B 0.0015
6165 Copper-transporting ATPase 1 ATP7A 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
6677 Myelin P2 protein PMP2 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
798 Osteocalcin BGLAP 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
4920 Peroxidase/catalase katG 0.0013
2119 Cytochrome b5 CYB5A 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
4990 PpcA ppcA 0.0013
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0013
3375 Acidic cytochrome c3 Not Available 0.0013
4988 Sulfite oxidase, mitochondrial SUOX 0.0013
4385 Cytochrome c' Not Available 0.0013
4967 Cytochrome c' cycA 0.0013
5038 Cytochrome c' Not Available 0.0013
5223 Cytochrome c' cycP 0.0013
2915 Sensor protein fixL fixL 0.0013
4944 Sensor protein fixL fixL 0.0013
3570 Cytochrome P450 152A1 cypC 0.0013
4037 Hypothetical protein GPX1 0.0013
4297 Hypothetical protein SP_1951 0.0013
4521 Hypothetical protein BC_2969 0.0013
4540 Hypothetical protein TM_1070 0.0013
4555 Hypothetical protein MT1739 0.0013
4569 Hypothetical protein mshD 0.0013
4578 Hypothetical protein PA3270 0.0013
4747 Hypothetical protein PA3967 0.0013
5177 Hypothetical protein TM_0096 0.0013
5194 Hypothetical protein PA1204 0.0013
5240 Hypothetical protein Rv2991 0.0013
5370 Hypothetical protein TM_1158 0.0013
5710 Hypothetical protein Tb927.5.1360 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
4813 Heme oxygenase hmuO 0.0013
5769 Heme oxygenase Not Available 0.0013
4289 Cytochrome P450 TT_P0059 0.0013
6262 Cytochrome P450 staP 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
1507 Cytochrome c CYCS 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
369 Coagulation factor VII F7 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
3670 Soluble cytochrome b562 precursor cybC 0.0011
3411 Cytochrome P450 121 cyp121 0.0011
3291 Cytochrome c-552 cycA 0.0011
4927 Cytochrome c-552 nrfA 0.0011
4938 Cytochrome c-552 cycA 0.0011
4953 Cytochrome c-552 nrfA 0.0011
5217 Cytochrome c-552 cycM 0.0011
2617 Nitric oxide synthase oxygenase nos 0.0011
2701 Nitric oxide synthase oxygenase nos 0.0011
3102 Flavohemoprotein hmp 0.0011
4969 Flavohemoprotein hmp 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.001
2972 6-deoxyerythronolide B hydroxylase eryF 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
1313 Lactoylglutathione lyase GLO1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
4608 Putative cytochrome P450 SCO1207 0.0009
4963 Putative cytochrome P450 SCO2884 0.0009
6254 Putative cytochrome P450 SCO6998 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
358 Cystathionine beta-synthase CBS 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
693 Hemoglobin subunit beta HBB 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
1867 Major prion protein PRNP 0.0008
6268 Hydroxyacid oxidase 1 HAO1 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
810 Heme oxygenase 1 HMOX1 0.0008
3391 Heme oxygenase 1 pbsA1 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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