DT-Web

DB00509 - Dextrothyroxine


Identification
Name Dextrothyroxine
Accession Number DB00509 (APRD00911)
Type small molecule
Description The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 776.87
Groups approved
Monoisotopic Weight 776.686681525
Pharmacology
Indication Used to lower high cholesterol levels in the blood.
Mechanism of action Dextrothyroxine is a antihyperlipidemic. The mechanism of action is not completely understood, but dextrothyroxine apparently acts in the liver to stimulate formation of low-density lipoprotein (LDL) and, to a much greater extent, to increase catabolism of LDL. This leads to increased excretion of cholesterol and bile acids via the biliary route into the feces, with a resulting reduction in serum cholesterol and LDL. Dextrothyroxine has no significant effect on high-density lipoproteins (HDL). Inherently, it will also bind to thyroid receptors and as it is a prohormone, it will bind as a substrate to iodide peroxidase.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Symptoms of dextrothyroxine overdose are unknown.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of acenocoumarol.
Anisindione The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of anisindione.
Dicumarol The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of dicumarol.
Digoxin The thyroid hormone, dextrothyroxine, decreases the effect of digoxin.
Warfarin The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of warfarin.
Food Interactions
  • Take without regard to meals.

Targets


Thyroid hormone receptor alpha
Name Thyroid hormone receptor alpha
Gene Name THRA
Pharmacological action yes
Actions agonist
References
  • Jiang W, Miyamoto T, Kakizawa T, Sakuma T, Nishio S, Takeda T, Suzuki S, Hashizume K: Expression of thyroid hormone receptor alpha in 3T3-L1 adipocytes; triiodothyronine increases the expression of lipogenic enzyme and triglyceride accumulation. J Endocrinol. 2004 Aug;182(2):295-302. - Pubmed
  • Kariv R, Enden A, Zvibel I, Rosner G, Brill S, Shafritz DA, Halpern Z, Oren R: Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line. Liver Int. 2003 Jun;23(3):187-93. - Pubmed
  • Mai W, Janier MF, Allioli N, Quignodon L, Chuzel T, Flamant F, Samarut J: Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10332-7. Epub 2004 Jul 6. - Pubmed
  • Sciaudone MP, Yao L, Schaller M, Zinn SA, Freake HC: Diethylenetriaminepentaacetic acid enhances thyroid hormone action by a transcriptional mechanism. Biol Trace Elem Res. 2004 Summer;99(1-3):219-31. - Pubmed
  • Timmer DC, Bakker O, Wiersinga WM: Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA. J Endocrinol. 2003 Nov;179(2):217-25. - Pubmed
  • Bernal J: Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59. - Pubmed
DTHybrid score 0.6384
Thyroid hormone receptor beta-1
Name Thyroid hormone receptor beta-1
Gene Name THRB
Pharmacological action yes
Actions agonist
References
  • Bernal J: Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59. - Pubmed
  • Gonzalez-Sancho JM, Garcia V, Bonilla F, Munoz A: Thyroid hormone receptors/THR genes in human cancer. Cancer Lett. 2003 Mar 31;192(2):121-32. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Yen PM, Feng X, Flamant F, Chen Y, Walker RL, Weiss RE, Chassande O, Samarut J, Refetoff S, Meltzer PS: Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. EMBO Rep. 2003 Jun;4(6):581-7. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
  • Wu SY, Sadow PM, Refetoff S, Weiss RE: Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor beta gene (P453T). J Lab Clin Med. 2005 Aug;146(2):85-94. - Pubmed
DTHybrid score 1.4064
Thyroid peroxidase
Name Thyroid peroxidase
Gene Name TPO
Pharmacological action unknown
Actions Not Available
References
  • Visser TJ: The elemental importance of sufficient iodine intake: a trace is not enough. Endocrinology. 2006 May;147(5):2095-7. - Pubmed
DTHybrid score 0.5406

Transporters


Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions Not Available
References
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score 0.4045
Solute carrier organic anion transporter family member 1C1
Name Solute carrier organic anion transporter family member 1C1
Gene Name SLCO1C1
Actions Not Available
References
  • Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. - Pubmed
DTHybrid score 0.3765
Solute carrier organic anion transporter family member 4A1
Name Solute carrier organic anion transporter family member 4A1
Gene Name SLCO4A1
Actions Not Available
References
  • Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. - Pubmed
DTHybrid score 0.3689
Solute carrier organic anion transporter family member 4C1
Name Solute carrier organic anion transporter family member 4C1
Gene Name SLCO4C1
Actions Not Available
References
  • Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. - Pubmed
DTHybrid score 0.4156
Large neutral amino acids transporter small subunit 1
Name Large neutral amino acids transporter small subunit 1
Gene Name SLC7A5
Actions Not Available
References
  • Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H: Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr;61(4):729-37. - Pubmed
DTHybrid score 0.6272

Predictions


Id Partner name Gene Name Score
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.231
594 Thyroxine-binding globulin SERPINA7 0.2037
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1972
6151 Monocarboxylate transporter 10 SLC16A10 0.1704
6142 Solute carrier family 22 member 8 SLC22A8 0.1491
1588 Multidrug resistance protein 1 ABCB1 0.1405
6369 Thyroid hormone receptor, alpha isoform 1 variant Not Available 0.1207
587 Serum albumin ALB 0.1197
373 Transthyretin TTR 0.1135
6141 Sodium/bile acid cotransporter SLC10A1 0.103
4512 Cytochrome P450 3A4 CYP3A4 0.1023
199 Monocarboxylate transporter 8 SLC16A2 0.1017
153 Dopamine beta-hydroxylase DBH 0.0927
3811 Cytochrome P450 19A1 CYP19A1 0.0925
4924 Cytochrome P450 2C8 CYP2C8 0.0858
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0771
1757 Myeloperoxidase MPO 0.068
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.0665
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0659
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.064
6147 Solute carrier family 22 member 3 SLC22A3 0.0608
6167 Organic solute transporter subunit beta OSTB 0.0597
6166 Organic solute transporter subunit alpha OSTA 0.0596
1566 Corticoliberin CRH 0.058
1729 Solute carrier family 22 member 6 SLC22A6 0.0535
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0507
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.049
862 Multidrug resistance-associated protein 1 ABCC1 0.0459
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0455
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0451
4757 Cytochrome P450 2C9 CYP2C9 0.0451
6016 Cytochrome P450 2C19 CYP2C19 0.0443
4200 Cytochrome P450 1A2 CYP1A2 0.0442
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.043
1024 Solute carrier family 22 member 11 SLC22A11 0.0413
4118 Cytochrome P450 3A5 CYP3A5 0.0383
2164 Multidrug resistance-associated protein 4 ABCC4 0.0366
4119 Cytochrome P450 2D6 CYP2D6 0.0337
6030 Cytochrome P450 2B6 CYP2B6 0.0318
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0311
776 Bile salt export pump ABCB11 0.0306
6024 Cytochrome P450 1A1 CYP1A1 0.0302
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0296
6145 Solute carrier family 22 member 1 SLC22A1 0.0273
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0252
6148 Multidrug resistance-associated protein 7 ABCC10 0.0225
3587 Gastrotropin FABP6 0.0214
6107 Cytochrome P450 3A7 CYP3A7 0.0212
6013 Cytochrome P450 2E1 CYP2E1 0.0199
5718 Cytochrome P450 2A6 CYP2A6 0.0189
275 Arachidonate 5-lipoxygenase ALOX5 0.0189
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0188
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0188
738 Monocarboxylate transporter 1 SLC16A1 0.0186
6143 Solute carrier family 22 member 7 SLC22A7 0.0183
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0174
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0164
20 Prostaglandin G/H synthase 1 PTGS1 0.016
952 Dipeptidyl peptidase 4 DPP4 0.016
6144 Solute carrier family 22 member 2 SLC22A2 0.0153
6149 Solute carrier family 22 member 10 SLC22A10 0.0151
118 Organic cation/carnitine transporter 2 SLC22A5 0.0147
833 Organic cation/carnitine transporter 1 SLC22A4 0.0144
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0136
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0134
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0127
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0127
136 Estrogen receptor ESR1 0.0126
6136 Multidrug resistance-associated protein 5 ABCC5 0.0125
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0124
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0123
5818 Folate receptor alpha FOLR1 0.012
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0119
70 Type-1 angiotensin II receptor AGTR1 0.0117
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0114
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0113
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0108
163 D(1B) dopamine receptor DRD5 0.0108
33 Cystine/glutamate transporter SLC7A11 0.0108
293 Gamma-glutamyl hydrolase GGH 0.0104
432 D(4) dopamine receptor DRD4 0.0103
638 D(3) dopamine receptor DRD3 0.01
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0099
290 Prostaglandin G/H synthase 2 PTGS2 0.0098
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0092
1650 Heme carrier protein 1 SLC46A1 0.0091
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.009
23 D(1A) dopamine receptor DRD1 0.0088
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0085
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
831 D(2) dopamine receptor DRD2 0.0083
6085 Fatty acid-binding protein, intestinal FABP2 0.0081
5880 Thrombopoietin receptor MPL 0.0081
3810 Catechol O-methyltransferase COMT 0.008
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0079
3917 Methylenetetrahydrofolate reductase MTHFR 0.0075
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0074
6106 Cytochrome P450 2C18 CYP2C18 0.0072
1898 Cytochrome P450 1B1 CYP1B1 0.007
756 Sex hormone-binding globulin SHBG 0.007
731 HIV-1 protease HIV-1 protease 0.0069
6020 Aldehyde oxidase AOX1 0.0069
24 Thymidylate synthase TMP1 0.0066
359 Thymidylate synthase TYMS 0.0066
2626 Thymidylate synthase thyA 0.0066
2729 Thymidylate synthase thyA 0.0066
5352 Thymidylate synthase THYA 0.0066
365 Dihydrofolate reductase DHFR 0.0062
2381 Dihydrofolate reductase DFR1 0.0062
2833 Dihydrofolate reductase Not Available 0.0062
2931 Dihydrofolate reductase folA 0.0062
3544 Dihydrofolate reductase folA 0.0062
3682 Dihydrofolate reductase folA 0.0062
6642 Dihydrofolate reductase folA 0.0062
6756 Dihydrofolate reductase dfrA 0.0062
869 Estrogen receptor beta ESR2 0.0061
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0057
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0055
26 Vascular endothelial growth factor receptor 3 FLT4 0.0055
32 Vascular endothelial growth factor receptor 1 FLT1 0.0053
4604 Liver carboxylesterase 1 CES1 0.0051
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0049
6218 Pannexin-1 PANX1 0.0047
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
407 Vascular endothelial growth factor receptor 2 KDR 0.0043
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0042
1502 Peroxisome proliferator-activated receptor delta PPARD 0.004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0039
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0036
2539 Tubulin alpha-1 chain TUBA4A 0.0035
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0035
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0035
4148 Serine/threonine-protein kinase mTOR MTOR 0.0035
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0034
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0034
511 5-hydroxytryptamine 1F receptor HTR1F 0.0034
1525 Heparin-binding growth factor 2 FGF2 0.0033
29 Tubulin beta-1 chain TUBB1 0.0032
1760 Aminopeptidase N ANPEP 0.0032
6843 Aminopeptidase N pepN 0.0032
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0031
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0031
117 Sterol O-acyltransferase 1 SOAT1 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0029
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0029
489 Monocarboxylate transporter 2 SLC16A7 0.0029
768 FK506-binding protein 1A FKBP1A 0.0029
6137 Multidrug resistance-associated protein 6 ABCC6 0.0029
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
468 Cytochrome P450 4A11 CYP4A11 0.0026
6168 Solute carrier family 22 member 16 SLC22A16 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0025
492 Histamine H1 receptor HRH1 0.0025
3856 Fibroblast growth factor receptor 3 FGFR3 0.0025
725 5-hydroxytryptamine 1D receptor HTR1D 0.0024
1630 Integrin beta-2 ITGB2 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0024
3941 Amine oxidase [flavin-containing] A MAOA 0.0024
3809 Estrogen-related receptor gamma ESRRG 0.0022
320 5-hydroxytryptamine 1A receptor HTR1A 0.0022
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0021
6044 Serum paraoxonase/lactonase 3 PON3 0.002
950 Alpha platelet-derived growth factor receptor PDGFRA 0.002
572 Integrin alpha-L ITGAL 0.0018
228 Beta platelet-derived growth factor receptor PDGFRB 0.0018
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0018
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
1353 DNA topoisomerase 1 TOP1 0.0018
3552 DNA topoisomerase 1 topA 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
267 Plasminogen activator inhibitor 1 SERPINE1 0.0017
504 Mast/stem cell growth factor receptor KIT 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
4122 Histone deacetylase 2 HDAC2 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0016
6221 Steroid hormone receptor ERR1 ESRRA 0.0016
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0015
751 Potassium channel subfamily K member 6 KCNK6 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0014
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0014
172 Potassium channel subfamily K member 1 KCNK1 0.0014
6220 Aryl hydrocarbon receptor AHR 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0013
284 DNA-directed RNA polymerase beta chain rpoB 0.0012
5773 DNA-directed RNA polymerase beta chain rpoB 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0011
3923 Cholinesterase BCHE 0.0011
2540 Choloylglycine hydrolase cbh 0.0011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0011
6501 Fatty acid-binding protein, liver FABP1 0.001
6031 Cytochrome P450 3A43 CYP3A43 0.001
6500 Phospholipase A2 PLA2G1B 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0008
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0007
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0006
824 Sodium-dependent serotonin transporter SLC6A4 0.0005
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