DT-Web

DB01324 - Polythiazide


Identification
Name Polythiazide
Accession Number DB01324
Type small molecule
Description A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 439.882
Groups approved
Monoisotopic Weight 438.970880311
Pharmacology
Indication Polythiazide is a thiazide diuretic used to decrease edema and decrease blood pressure.
Mechanism of action As a diuretic, polythiazide inhibits active chloride reabsorption at the early distal tubule via the thiazide-sensitive Na-Cl cotransporter (TSC), resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like polythiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of polythiazide may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Digoxin Possible electrolyte variations and arrhythmias
Lithium The thiazide diuretic, polythiazide, may increase serum levels of lithium.
Trandolapril The thiazide diuretic, Polythiazide, may increase the hypotensive effect of Trandolapril. Polythiazide may also increase the nephrotoxicity of Trandolapril. Monitor for postural hypotension at initiation of concomitant therapy and renal dysfunction during chronic therapy.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Food Interactions Not Available

Targets


Solute carrier family 12 member 3
Name Solute carrier family 12 member 3
Gene Name SLC12A3
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Monroy A, Plata C, Hebert SC, Gamba G: Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction. Am J Physiol Renal Physiol. 2000 Jul;279(1):F161-9. - Pubmed
  • Frindt G, McNair T, Dahlmann A, Jacobs-Palmer E, Palmer LG: Epithelial Na channels and short-term renal response to salt deprivation. Am J Physiol Renal Physiol. 2002 Oct;283(4):F717-26. - Pubmed
DTHybrid score 0.6195

Predictions


Id Partner name Gene Name Score
295 Carbonic anhydrase 1 CA1 0.1244
357 Carbonic anhydrase 2 CA2 0.0897
592 Carbonic anhydrase 4 CA4 0.0881
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0638
3007 Carbonic anhydrase 12 CA12 0.0507
4205 Carbonic anhydrase 9 CA9 0.0507
310 Solute carrier family 12 member 2 SLC12A2 0.0361
558 Solute carrier family 12 member 1 SLC12A1 0.0283
1729 Solute carrier family 22 member 6 SLC22A6 0.0263
1405 Thiopurine S-methyltransferase TPMT 0.0258
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0205
3426 Glutamine synthetase glnA 0.0198
3987 Glutamine synthetase GLUL 0.0198
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0181
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