DT-Web

DB00544 - Fluorouracil


Identification
Name Fluorouracil
Accession Number DB00544 (APRD00516, EXPT03204)
Type small molecule
Description A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 130.0772
Groups approved
Monoisotopic Weight 130.017855555
Pharmacology
Indication For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
Mechanism of action The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the drug (FdUMP) and the folate cofactor, N5-10-methylenetetrahydrofolate, to thymidylate synthase (TS) to form a covalently bound ternary complex. This results in the inhibition of the formation of thymidylate from uracil, which leads to the inhibition of DNA and RNA synthesis and cell death. Fluorouracil can also be incorporated into RNA in place of uridine triphosphate (UTP), producing a fraudulent RNA and interfering with RNA processing and protein synthesis.
Absorption 28-100%
Protein binding 8-12%
Biotransformation Hepatic. The catabolic metabolism of fluorouracil results in degradation products ( e.g., CO2, urea and ?-fluoro-ss-alanine) which are inactive.
Route of elimination Seven percent to 20% of the parent drug is excreted unchanged in the urine in 6 hours; of this over 90% is excreted in the first hour. The remaining percentage of the administered dose is metabolized, primarily in the liver.
Toxicity LD50=230mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The antineoplasic agent, fluorouracil, may increase the anticoagulant effect of acenocoumarol.
Anisindione The antineoplasic agent, fluorouracil, may increase the anticoagulant effect of anisindione.
Dicumarol The antineoplasic agent, fluorouracil, may increase the anticoagulant effect of dicumarol.
Ethotoin Fluorouracil increases the effect of hydantoin
Fosphenytoin Fluorouracil increases the effect of hydantoin
Mephenytoin Fluorouracil increases the effect of hydantoin
Metronidazole Risk of 5-FU toxicity when associated with metronidazole
Phenytoin Fluorouracil increases the effect of hydantoin
Tamoxifen Fluorouracil may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Fluorouracil is initiated, discontinued or dose changed.
Temsirolimus Co-administration of Temsirolimus and Fluorouracil may result in serious adverse drug reactions.
Tolbutamide Fluorouracil, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Fluorouracil is initiated, discontinued or dose changed.
Torasemide Fluorouracil, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Fluorouracil is initiated, discontinued or dose changed.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Trimethoprim The strong CYP2C9 inhibitor, Fluorouracil, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Fluorouracil is initiated, discontinued or dose changed.
Voriconazole Fluorouracil, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of voriconazole if fluorouracil is initiated, discontinued or dose changed.
Warfarin Fluorouracil, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if fluorouracil is initiated, discontinued or dose changed.
Zafirlukast Fluorouracil, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of zafirlukast. Consider alternate therapy or monitor for changes in zafirlukast therapeutic and adverse effects if fluorouracil is initiated, discontinued or dose changed.
Food Interactions
  • Vitamin B1 needs increased with long term use.

Targets


Thymidylate synthase
Name Thymidylate synthase
Gene Name TYMS
Pharmacological action yes
Actions other/unknown
References
  • Formentini A, Sander S, Denzer S, Straeter J, Henne-Bruns D, Kornmann M: Thymidylate synthase expression in resectable and unresectable pancreatic cancer: role as predictive or prognostic marker? Int J Colorectal Dis. 2007 Jan;22(1):49-55. Epub 2006 Mar 15. - Pubmed
  • Huang CL, Yokomise H, Fukushima M, Kinoshita M: Tailor-made chemotherapy for non-small cell lung cancer patients. Future Oncol. 2006 Apr;2(2):289-99. - Pubmed
  • Fernandez-Contreras ME, Sanchez-Prudencio S, Sanchez-Hernandez JJ, Garcia de Paredes ML, Gisbert JP, Roda-Navarro P, Gamallo C: Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil. Int J Oncol. 2006 May;28(5):1303-10. - Pubmed
  • Garcia V, Garcia JM, Pena C, Silva J, Dominguez G, Hurtado A, Alonso I, Rodriguez R, Provencio M, Bonilla F: Thymidylate synthase messenger RNA expression in plasma from patients with colon cancer: prognostic potential. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2095-100. - Pubmed
  • Ploylearmsaeng SA, Fuhr U, Jetter A: How may anticancer chemotherapy with fluorouracil be individualised? Clin Pharmacokinet. 2006;45(6):567-92. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Rustum YM: Thymidylate synthase: a critical target in cancer therapy? Front Biosci. 2004 Sep 1;9:2467-73. - Pubmed
DTHybrid score 0.9226
DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions incorporation into and destabilization
References
  • Wyatt MD, Wilson DM 3rd: Participation of DNA repair in the response to 5-fluorouracil. Cell Mol Life Sci. 2009 Mar;66(5):788-99. - Pubmed
  • Ghoshal K, Jacob ST: An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol. 1997 Jun 1;53(11):1569-75. - Pubmed
  • Longley DB, Harkin DP, Johnston PG: 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003 May;3(5):330-8. - Pubmed
  • Petty RD, Cassidy J: Novel fluoropyrimidines: improving the efficacy and tolerability of cytotoxic therapy. Curr Cancer Drug Targets. 2004 Mar;4(2):191-204. - Pubmed
DTHybrid score Not Available
RNA
Name RNA
Gene Name Not Available
Pharmacological action yes
Actions incorporation into and destabilization
References
  • Wyatt MD, Wilson DM 3rd: Participation of DNA repair in the response to 5-fluorouracil. Cell Mol Life Sci. 2009 Mar;66(5):788-99. - Pubmed
  • Ghoshal K, Jacob ST: An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol. 1997 Jun 1;53(11):1569-75. - Pubmed
  • Longley DB, Harkin DP, Johnston PG: 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003 May;3(5):330-8. - Pubmed
  • Petty RD, Cassidy J: Novel fluoropyrimidines: improving the efficacy and tolerability of cytotoxic therapy. Curr Cancer Drug Targets. 2004 Mar;4(2):191-204. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5869
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.464
Thymidine phosphorylase
Name Thymidine phosphorylase
Gene Name TYMP
Actions substrate
References
  • Scartozzi M, Maccaroni E, Giampieri R, Pistelli M, Bittoni A, Del Prete M, Berardi R, Cascinu S: 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65. - Pubmed
DTHybrid score 0.884
Dihydropyrimidine dehydrogenase [NADP+]
Name Dihydropyrimidine dehydrogenase [NADP+]
Gene Name DPYD
Actions substrate
References
  • Ho DH, Townsend L, Luna MA, Bodey GP: Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate. Anticancer Res. 1986 Jul-Aug;6(4):781-4. - Pubmed
  • Keizer HJ, De Bruijn EA, Tjaden UR, De Clercq E: Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine. J Cancer Res Clin Oncol. 1994;120(9):545-9. - Pubmed
DTHybrid score 0.9182
Uridine phosphorylase 1
Name Uridine phosphorylase 1
Gene Name UPP1
Actions substrate
References
  • Yan R, Wan L, Pizzorno G, Cao D: Uridine phosphorylase in breast cancer: a new prognostic factor? Front Biosci. 2006 Sep 1;11:2759-66. - Pubmed
DTHybrid score 0.6758
Uridine phosphorylase 2
Name Uridine phosphorylase 2
Gene Name UPP2
Actions substrate
References
  • Yan R, Wan L, Pizzorno G, Cao D: Uridine phosphorylase in breast cancer: a new prognostic factor? Front Biosci. 2006 Sep 1;11:2759-66. - Pubmed
DTHybrid score 0.285
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3894
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4304
Methylenetetrahydrofolate reductase
Name Methylenetetrahydrofolate reductase
Gene Name MTHFR
Actions substrate
References
  • Scartozzi M, Maccaroni E, Giampieri R, Pistelli M, Bittoni A, Del Prete M, Berardi R, Cascinu S: 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65. - Pubmed
DTHybrid score 0.2845
Thymidylate synthase
Name Thymidylate synthase
Gene Name TYMS
Actions substrate
References
  • Scartozzi M, Maccaroni E, Giampieri R, Pistelli M, Bittoni A, Del Prete M, Berardi R, Cascinu S: 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65. - Pubmed
DTHybrid score 0.9226
Uridine 5'-monophosphate synthase
Name Uridine 5'-monophosphate synthase
Gene Name UMPS
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150653776 -
DTHybrid score Not Available
Amidophosphoribosyltransferase
Name Amidophosphoribosyltransferase
Gene Name PPAT
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150653776 -
DTHybrid score 0.2445

Transporters


Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions substrate
References
  • Kobayashi Y, Ohshiro N, Sakai R, Ohbayashi M, Kohyama N, Yamamoto T: Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8. - Pubmed
DTHybrid score 0.2944
Equilibrative nucleoside transporter 1
Name Equilibrative nucleoside transporter 1
Gene Name SLC29A1
Actions substrate
References
  • Tsujie M, Nakamori S, Nakahira S, Takahashi Y, Hayashi N, Okami J, Nagano H, Dono K, Umeshita K, Sakon M, Monden M: Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 2007 Jul-Aug;27(4B):2241-9. - Pubmed
DTHybrid score 0.4252
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Yuan J, Lv H, Peng B, Wang C, Yu Y, He Z: Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10. doi: 10.1007/s00280-008-0838-z. Epub 2008 Sep 27. - Pubmed
DTHybrid score 0.3521
Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions substrate
References
  • Hagmann W, Jesnowski R, Faissner R, Guo C, Lohr JM: ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44. doi: 10.1159/000178884. Epub 2008 Dec 13. - Pubmed
DTHybrid score 0.299
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions substrate
References
  • Hagmann W, Jesnowski R, Faissner R, Guo C, Lohr JM: ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44. doi: 10.1159/000178884. Epub 2008 Dec 13. - Pubmed
DTHybrid score 0.3992
Multidrug resistance-associated protein 5
Name Multidrug resistance-associated protein 5
Gene Name ABCC5
Actions substrate
References
  • Hagmann W, Jesnowski R, Faissner R, Guo C, Lohr JM: ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44. doi: 10.1159/000178884. Epub 2008 Dec 13. - Pubmed
DTHybrid score 0.2931

Carriers


Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions
References Not Available
DTHybrid score 0.2944
Equilibrative nucleoside transporter 1
Name Equilibrative nucleoside transporter 1
Gene Name SLC29A1
Actions
References Not Available
DTHybrid score 0.4252
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions
References Not Available
DTHybrid score 0.3521
Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions
References Not Available
DTHybrid score 0.299
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions
References Not Available
DTHybrid score 0.3992
Multidrug resistance-associated protein 5
Name Multidrug resistance-associated protein 5
Gene Name ABCC5
Actions
References Not Available
DTHybrid score 0.2931

Predictions


Id Partner name Gene Name Score
24 Thymidylate synthase TMP1 0.9226
2626 Thymidylate synthase thyA 0.9226
2729 Thymidylate synthase thyA 0.9226
5352 Thymidylate synthase THYA 0.9226
3639 Thymidine phosphorylase deoA 0.884
4512 Cytochrome P450 3A4 CYP3A4 0.4045
1588 Multidrug resistance protein 1 ABCB1 0.3003
1729 Solute carrier family 22 member 6 SLC22A6 0.2944
6016 Cytochrome P450 2C19 CYP2C19 0.2858
2257 Uridine phosphorylase udp 0.2633
5132 Uridine phosphorylase udp 0.2633
2515 Amidophosphoribosyltransferase purF 0.2445
3714 Amidophosphoribosyltransferase purF 0.2445
4119 Cytochrome P450 2D6 CYP2D6 0.2362
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1839
4118 Cytochrome P450 3A5 CYP3A5 0.1786
6030 Cytochrome P450 2B6 CYP2B6 0.1725
6142 Solute carrier family 22 member 8 SLC22A8 0.17
6013 Cytochrome P450 2E1 CYP2E1 0.1695
6107 Cytochrome P450 3A7 CYP3A7 0.1352
6024 Cytochrome P450 1A1 CYP1A1 0.1342
862 Multidrug resistance-associated protein 1 ABCC1 0.1279
20 Prostaglandin G/H synthase 1 PTGS1 0.1278
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1195
3611 Cytidine deaminase cdd 0.1188
3707 Cytidine deaminase cdd 0.1188
4211 Cytidine deaminase CDA 0.1188
4773 Deoxycytidine kinase DCK 0.1168
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1167
1024 Solute carrier family 22 member 11 SLC22A11 0.1097
2320 Thymidine kinase, cytosolic TK1 0.0972
290 Prostaglandin G/H synthase 2 PTGS2 0.0948
6171 Solute carrier family 28 member 3 SLC28A3 0.0936
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0859
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.085
6148 Multidrug resistance-associated protein 7 ABCC10 0.0814
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0801
4604 Liver carboxylesterase 1 CES1 0.0779
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0747
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0742
365 Dihydrofolate reductase DHFR 0.0734
2381 Dihydrofolate reductase DFR1 0.0734
2833 Dihydrofolate reductase Not Available 0.0734
2931 Dihydrofolate reductase folA 0.0734
3544 Dihydrofolate reductase folA 0.0734
3682 Dihydrofolate reductase folA 0.0734
6642 Dihydrofolate reductase folA 0.0734
6756 Dihydrofolate reductase dfrA 0.0734
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0721
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0693
6145 Solute carrier family 22 member 1 SLC22A1 0.0664
776 Bile salt export pump ABCB11 0.0652
6144 Solute carrier family 22 member 2 SLC22A2 0.0642
6106 Cytochrome P450 2C18 CYP2C18 0.0626
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0609
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0565
1898 Cytochrome P450 1B1 CYP1B1 0.0546
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0541
6020 Aldehyde oxidase AOX1 0.0525
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0523
6137 Multidrug resistance-associated protein 6 ABCC6 0.0517
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0507
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0504
3947 Xanthine dehydrogenase/oxidase XDH 0.0499
3811 Cytochrome P450 19A1 CYP19A1 0.0492
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0477
3496 Uracil-DNA glycosylase UL2 0.0469
3512 Uracil-DNA glycosylase ung 0.0469
5257 Uracil-DNA glycosylase udg 0.0469
6272 Uracil-DNA glycosylase UNG 0.0469
5258 Pyrimidine-nucleoside phosphorylase pdp 0.0469
6141 Sodium/bile acid cotransporter SLC10A1 0.0467
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0453
293 Gamma-glutamyl hydrolase GGH 0.0445
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0424
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0422
3941 Amine oxidase [flavin-containing] A MAOA 0.0421
6147 Solute carrier family 22 member 3 SLC22A3 0.0415
1650 Heme carrier protein 1 SLC46A1 0.0406
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.0404
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.0404
118 Organic cation/carnitine transporter 2 SLC22A5 0.0392
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.039
738 Monocarboxylate transporter 1 SLC16A1 0.039
891 Dihydropteroate synthase folP 0.0379
5359 Dihydropteroate synthase folP 0.0379
7175 Dihydropteroate synthase sulI 0.0379
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0376
603 DNA polymerase alpha catalytic subunit POLA1 0.036
220 Sodium channel protein type 5 subunit alpha SCN5A 0.036
6031 Cytochrome P450 3A43 CYP3A43 0.0357
408 Riboflavin kinase RFK 0.0349
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0348
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0348
2826 Glucose--fructose oxidoreductase gfo 0.0347
468 Cytochrome P450 4A11 CYP4A11 0.0346
277 Purine nucleoside phosphorylase PNP 0.0343
2870 Purine nucleoside phosphorylase punA 0.0343
2945 Purine nucleoside phosphorylase punA 0.0343
4659 Purine nucleoside phosphorylase TM_1596 0.0343
4825 Purine nucleoside phosphorylase TTHA1435 0.0343
2675 Pteridine reductase 1 PTR1 0.0343
5698 Riboflavin synthase alpha chain ribE 0.0336
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0331
136 Estrogen receptor ESR1 0.033
244 Angiotensin-converting enzyme ACE 0.0325
36 Insulin receptor INSR 0.0325
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0324
5626 Nucleoside diphosphate kinase B NME2 0.0323
718 Folate receptor gamma FOLR3 0.032
804 Mitochondrial folate transporter/carrier SLC25A32 0.032
299 Folate receptor beta FOLR2 0.032
702 UMP-CMP kinase CMPK1 0.032
492 Histamine H1 receptor HRH1 0.031
1405 Thiopurine S-methyltransferase TPMT 0.0308
809 Methionine synthase MTR 0.0307
2935 Methionine synthase metH 0.0307
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0299
1008 CTP synthase 1 CTPS 0.0299
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0299
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0299
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0299
3989 Glutaminyl-tRNA synthetase QARS 0.0299
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0299
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0299
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0295
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0295
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0291
502 5-hydroxytryptamine 2A receptor HTR2A 0.029
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0289
6085 Fatty acid-binding protein, intestinal FABP2 0.0282
824 Sodium-dependent serotonin transporter SLC6A4 0.028
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0278
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.027
817 DNA topoisomerase 2-alpha TOP2A 0.0269
3426 Glutamine synthetase glnA 0.0266
3987 Glutamine synthetase GLUL 0.0266
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0265
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0263
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.026
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.026
5294 Nucleoside diphosphate kinase A NME1 0.0257
3685 Catabolite gene activator crp 0.0254
4655 Adenylate cyclase cyaC 0.0254
4759 Adenylate cyclase cyaB2 0.0254
844 Epidermal growth factor receptor EGFR 0.0249
654 Flavin reductase BLVRB 0.0247
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0246
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0246
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0243
5261 Phosphoribosylformylglycinamidine synthase purL 0.0243
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0243
5 Glutaminase liver isoform, mitochondrial GLS2 0.0243
917 Glutaminase kidney isoform, mitochondrial GLS 0.0243
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0243
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0243
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0243
831 D(2) dopamine receptor DRD2 0.0241
263 Neutral amino acid transporter B(0) SLC1A5 0.024
840 Methionine synthase reductase, mitochondrial MTRR 0.0238
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0233
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0233
342 P protein [Includes: DNA-directed DNA polymerase P 0.023
612 P protein [Includes: DNA-directed DNA polymerase P 0.023
6149 Solute carrier family 22 member 10 SLC22A10 0.0228
311 RNA-directed RNA polymerase catalytic subunit PB1 0.0227
752 Large structural protein L 0.0227
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0224
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0223
504 Mast/stem cell growth factor receptor KIT 0.0216
314 System N amino acid transporter 1 SLC38A3 0.0216
4760 Mll3241 protein mll3241 0.0216
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0215
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0212
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0211
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.021
6 Coagulation factor XIII A chain F13A1 0.0209
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0206
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0204
6014 Cytochrome P450 2A13 CYP2A13 0.0202
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0202
4217 Telomerase reverse transcriptase TERT 0.0202
6151 Monocarboxylate transporter 10 SLC16A10 0.0202
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0201
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.02
540 Sodium-dependent noradrenaline transporter SLC6A2 0.02
908 Glutathione S-transferase theta-1 GSTT1 0.0199
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0198
556 Alpha-1A adrenergic receptor ADRA1A 0.0197
3957 Adenosine deaminase ADA 0.0196
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0196
590 5-hydroxytryptamine 2C receptor HTR2C 0.0196
23 D(1A) dopamine receptor DRD1 0.0196
1830 5'-nucleotidase NT5E 0.0192
5818 Folate receptor alpha FOLR1 0.0192
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0191
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0189
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0189
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0188
70 Type-1 angiotensin II receptor AGTR1 0.0186
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0183
6167 Organic solute transporter subunit beta OSTB 0.0182
6166 Organic solute transporter subunit alpha OSTA 0.0182
341 5-hydroxytryptamine 3 receptor HTR3A 0.0181
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.018
508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 0.0179
33 Cystine/glutamate transporter SLC7A11 0.0179
3939 Amine oxidase [flavin-containing] B MAOB 0.0179
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0177
117 Sterol O-acyltransferase 1 SOAT1 0.0177
320 5-hydroxytryptamine 1A receptor HTR1A 0.0176
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0176
904 Glutathione S-transferase P GSTP1 0.0174
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0173
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0173
318 Alpha-2A adrenergic receptor ADRA2A 0.0172
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0171
228 Beta platelet-derived growth factor receptor PDGFRB 0.0171
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0171
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0171
6220 Aryl hydrocarbon receptor AHR 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0169
16 Adenosine A1 receptor ADORA1 0.0169
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0169
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0168
766 Beta-2 adrenergic receptor ADRB2 0.0167
465 Calmodulin CALM1 0.0165
833 Organic cation/carnitine transporter 1 SLC22A4 0.0164
6102 Arylamine N-acetyltransferase 2 NAT2 0.0164
125 DNA polymerase beta POLB 0.0163
713 Sodium-dependent dopamine transporter SLC6A3 0.0162
632 Alpha-1B adrenergic receptor ADRA1B 0.0162
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0161
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0161
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0161
6021 Adenosine kinase ADK 0.0159
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0159
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0158
1757 Myeloperoxidase MPO 0.0158
4120 NADPH--cytochrome P450 reductase POR 0.0157
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0157
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0155
1178 Adenosine A2a receptor ADORA2A 0.0155
2567 Thymidylate synthase thyX thyX 0.0154
26 Vascular endothelial growth factor receptor 3 FLT4 0.0154
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0153
885 5-hydroxytryptamine 1B receptor HTR1B 0.0153
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0152
507 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial MMAB 0.0152
3916 Methylmalonic aciduria and homocystinuria type C protein MMACHC 0.0152
354 Methylmalonic aciduria type A protein, mitochondrial MMAA 0.0152
398 Transcobalamin-2 TCN2 0.0152
265 Transcobalamin-1 TCN1 0.0152
376 Amnionless protein AMN 0.0152
854 Methylmalonyl-CoA mutase, mitochondrial MUT 0.0152
275 Arachidonate 5-lipoxygenase ALOX5 0.0152
1224 Cubilin CUBN 0.0152
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0151
869 Estrogen receptor beta ESR2 0.0149
3809 Estrogen-related receptor gamma ESRRG 0.0148
407 Vascular endothelial growth factor receptor 2 KDR 0.0148
509 Thymidine kinase TK 0.0147
570 Thymidine kinase TK 0.0147
2559 Thymidine kinase TK 0.0147
3430 Thymidine kinase tdk 0.0147
3518 Thymidine kinase TK 0.0147
5301 Thymidine kinase tdk 0.0147
5771 Thymidine kinase ORF36 0.0147
7009 Thymidine kinase ORF36 0.0147
756 Sex hormone-binding globulin SHBG 0.0147
32 Vascular endothelial growth factor receptor 1 FLT1 0.0147
477 DNA topoisomerase 4 subunit A parC 0.0147
886 DNA topoisomerase 4 subunit A parC 0.0147
6226 DNA topoisomerase 4 subunit A parC 0.0147
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
1353 DNA topoisomerase 1 TOP1 0.0144
3552 DNA topoisomerase 1 topA 0.0144
4122 Histone deacetylase 2 HDAC2 0.0143
6033 High affinity interleukin-8 receptor A CXCR1 0.0143
122 P2Y purinoceptor 12 P2RY12 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
183 Vascular endothelial growth factor A VEGFA 0.0142
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0141
731 HIV-1 protease HIV-1 protease 0.014
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.014
696 Kappa-type opioid receptor OPRK1 0.0139
482 Glycine receptor subunit alpha-1 GLRA1 0.0139
6218 Pannexin-1 PANX1 0.0139
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0139
871 Glucocorticoid receptor NR3C1 0.0138
260 Cytochrome P450 51 ERG11 0.0138
761 Cytochrome P450 51 ERG11 0.0138
3163 Cytochrome P450 51 cyp51 0.0138
373 Transthyretin TTR 0.0137
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0137
725 5-hydroxytryptamine 1D receptor HTR1D 0.0137
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0137
400 Coagulation factor IX F9 0.0135
5461 Coagulation factor IX F9 0.0135
6146 High affinity copper uptake protein 1 SLC31A1 0.0135
847 Mu-type opioid receptor OPRM1 0.0134
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0134
273 Apoptosis regulator Bcl-2 BCL2 0.0133
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0132
896 Glutathione S-transferase Mu 1 GSTM1 0.0131
3810 Catechol O-methyltransferase COMT 0.013
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0129
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0129
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0129
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0129
4275 PCZA361.16 Not Available 0.0128
4276 DNA polymerase III subunit epsilon dnaQ 0.0128
3923 Cholinesterase BCHE 0.0128
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0127
146 Androgen receptor AR 0.0127
543 Penicillin-binding protein 1B mrcB 0.0126
6186 Penicillin-binding protein 1B ponB 0.0126
6822 Penicillin-binding protein 1b pbp1b 0.0126
6844 Penicillin-binding protein 1b pbp1b 0.0126
1648 Elastin ELN 0.0126
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0126
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0125
604 Vitamin K-dependent protein Z PROZ 0.0125
1 Peptidoglycan synthetase ftsI ftsI 0.0125
4155 Peptidoglycan synthetase ftsI ftsI 0.0125
537 ATP synthase delta chain, mitochondrial ATP5D 0.0125
467 Delta-type opioid receptor OPRD1 0.0124
645 Penicillin-binding protein 1A mrcA 0.0124
5805 Penicillin-binding protein 1A ponA 0.0124
6185 Penicillin-binding protein 1A mrcA 0.0124
6799 Penicillin-binding protein 1A pbpA 0.0124
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0124
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0123
317 Methionine-R-sulfoxide reductase SEPX1 0.0123
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0122
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0122
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0122
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0122
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0122
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0122
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0122
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0122
4238 50S ribosomal protein L4 rplD 0.0122
5578 50S ribosomal protein L4 rplD 0.0122
6173 50S ribosomal protein L4 rplD 0.0122
6219 50S ribosomal protein L4 rplD 0.0122
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0121
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0121
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.012
2183 Fatty acid-binding protein, adipocyte FABP4 0.0119
6165 Copper-transporting ATPase 1 ATP7A 0.0118
6163 Copper-transporting ATPase 2 ATP7B 0.0118
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0117
29 Tubulin beta-1 chain TUBB1 0.0115
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0114
2555 Pol polyprotein pol 0.0114
3242 Pol polyprotein gag-pol 0.0114
3471 Pol polyprotein gag-pro-pol 0.0114
5256 Pol polyprotein pol 0.0114
6469 Pol polyprotein gag-pol 0.0114
6565 Pol polyprotein Not Available 0.0114
284 DNA-directed RNA polymerase beta chain rpoB 0.0114
5773 DNA-directed RNA polymerase beta chain rpoB 0.0114
1245 Vitamin K-dependent protein S PROS1 0.0113
422 Vitamin K-dependent protein C PROC 0.0113
992 Protein tyrosine kinase 2 beta PTK2B 0.0112
4237 50S ribosomal protein L22 rplV 0.0112
705 Glutamate receptor 1 GRIA1 0.0112
811 Translocator protein TSPO 0.0111
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0111
165 FL cytokine receptor FLT3 0.011
380 Cytochrome P450 17A1 CYP17A1 0.011
3932 Glutathione S-transferase A2 GSTA2 0.0109
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0109
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0109
59 AMT protein AMT 0.0109
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0109
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0108
2211 Fatty acid-binding protein, heart FABP3 0.0108
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0107
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0107
558 Solute carrier family 12 member 1 SLC12A1 0.0106
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0106
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0106
22 30S ribosomal protein S4 rpsD 0.0104
6714 30S ribosomal protein S4 rpsD 0.0104
489 Monocarboxylate transporter 2 SLC16A7 0.0104
2539 Tubulin alpha-1 chain TUBA4A 0.0103
789 Alpha-1D adrenergic receptor ADRA1D 0.0102
191 Peptide methionine sulfoxide reductase MSRA 0.0102
115 Penicillin-binding protein 2 mrdA 0.0102
6069 Penicillin-binding protein 2 mrdA 0.0102
6118 Penicillin-binding protein 2 penA 0.0102
6187 Penicillin-binding protein 2 pbpA 0.0102
6686 Penicillin-binding protein 2 pbp2 0.0102
6939 Penicillin-binding protein 2 mrdA 0.0102
7163 Penicillin-binding protein 2 pbpA 0.0102
2298 Cytochrome P450-cam camC 0.0102
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0102
6182 Cytochrome P450 2J2 CYP2J2 0.0101
3587 Gastrotropin FABP6 0.0101
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0101
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0101
448 Vitamin K-dependent gamma-carboxylase GGCX 0.01
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0099
6043 Putative G-protein coupled receptor 44 GPR44 0.0099
140 30S ribosomal protein S9 rpsI 0.0098
6719 30S ribosomal protein S9 rpsI 0.0098
6725 30S ribosomal protein S9 rpsI 0.0098
2251 Thymidylate kinase tmk 0.0098
2254 Thymidylate kinase DTYMK 0.0098
3522 Thymidylate kinase tmk 0.0098
239 Coagulation factor X F10 0.0098
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0097
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0097
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
1313 Lactoylglutathione lyase GLO1 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
714 Glutathione reductase, mitochondrial GSR 0.0097
527 Prostacyclin receptor PTGIR 0.0096
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0096
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0096
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0095
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0095
566 Serotransferrin TF 0.0094
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0094
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0094
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0094
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0094
2981 Phospholipase A2, membrane associated PLA2G2A 0.0093
1867 Major prion protein PRNP 0.0093
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0092
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0092
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0092
193 Beta-1 adrenergic receptor ADRB1 0.0092
629 Alpha-2B adrenergic receptor ADRA2B 0.0091
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0091
798 Osteocalcin BGLAP 0.009
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.009
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.009
94 5-hydroxytryptamine 4 receptor HTR4 0.0089
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0088
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0087
5353 Glutamate decarboxylase alpha gadA 0.0087
4116 Dihydropteroate synthetase Not Available 0.0087
511 5-hydroxytryptamine 1F receptor HTR1F 0.0087
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0085
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0085
13 Aminomethyltransferase, mitochondrial AMT 0.0084
5787 Angiopoietin-1 receptor TEK 0.0084
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0084
3361 Serpin B5 SERPINB5 0.0084
5694 Transcription antiterminator licT licT 0.0084
818 50S ribosomal protein L10 rplJ 0.0083
638 D(3) dopamine receptor DRD3 0.0082
3884 SHMT2 protein SHMT2 0.0081
3901 SHMT2 protein SHMT2 0.0081
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0081
3879 Serine hydroxymethyltransferase 2 Not Available 0.0081
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0081
1760 Aminopeptidase N ANPEP 0.0081
6843 Aminopeptidase N pepN 0.0081
88 Retinoic acid receptor RXR-beta RXRB 0.0081
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0081
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
6207 30S ribosomal protein S14 rpsN 0.008
6209 30S ribosomal protein S19 rpsS 0.008
6712 30S ribosomal protein S19 rpsS 0.008
6726 30S ribosomal protein S19 rpsS 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
267 Plasminogen activator inhibitor 1 SERPINE1 0.0079
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0079
6599 HTH-type transcriptional regulator ttgR ttgR 0.0079
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0079
369 Coagulation factor VII F7 0.0079
571 Melatonin receptor type 1A MTNR1A 0.0078
921 Glutamate receptor 2 GRIA2 0.0078
362 Melatonin receptor type 1B MTNR1B 0.0078
517 Alcohol dehydrogenase 1C ADH1C 0.0078
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0077
777 Tumor necrosis factor TNF 0.0077
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0077
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0076
6042 Prostaglandin reductase 2 PTGR2 0.0076
436 5-hydroxytryptamine 2B receptor HTR2B 0.0075
161 Tubulin beta chain TUBB 0.0075
312 Tubulin beta chain TUB2 0.0075
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0075
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0075
5924 Microtubule-associated protein 4 MAP4 0.0075
5923 Microtubule-associated protein tau MAPT 0.0075
54 Prothrombin F2 0.0075
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0075
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0074
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0074
4192 DNA topoisomerase 2-beta TOP2B 0.0073
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0072
518 Peroxidase/catalase T katG 0.0072
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
378 Alpha-2C adrenergic receptor ADRA2C 0.0071
6221 Steroid hormone receptor ERR1 ESRRA 0.007
2230 Catalase CAT 0.007
3249 Catalase katA 0.007
3625 Catalase katA 0.007
4539 Catalase katA 0.007
4941 Catalase katB 0.007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.007
1852 Microtubule-associated protein 2 MAP2 0.0069
338 DNA polymerase UL30 0.0069
379 DNA polymerase UL54 0.0069
697 DNA polymerase ORF28 0.0069
2482 DNA polymerase 43 0.0069
4104 DNA polymerase BALF5 0.0069
106 Cannabinoid receptor 2 CNR2 0.0069
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0069
76 Nitric-oxide synthase, brain NOS1 0.0068
2853 14 kDa fatty acid-binding protein Not Available 0.0068
1192 Sulfotransferase 1A1 SULT1A1 0.0068
56 Delta-aminolevulinic acid dehydratase ALAD 0.0067
2356 Delta-aminolevulinic acid dehydratase hemB 0.0067
3613 Delta-aminolevulinic acid dehydratase hemB 0.0067
3674 Delta-aminolevulinic acid dehydratase hemB 0.0067
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0067
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0067
2795 Methionine aminopeptidase 2 METAP2 0.0066
1050 Bile salt sulfotransferase SULT2A1 0.0066
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0066
68 Cannabinoid receptor 1 CNR1 0.0065
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0065
780 Retinoic acid receptor RXR-gamma RXRG 0.0065
819 Penicillin-binding protein 4 dacB 0.0065
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0065
162 Retinoic acid receptor gamma-1 RARG 0.0065
952 Dipeptidyl peptidase 4 DPP4 0.0065
6501 Fatty acid-binding protein, liver FABP1 0.0065
1198 Serum paraoxonase/arylesterase 1 PON1 0.0065
6223 Penicillin-binding protein 1C pbpC 0.0065
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0064
1010 Cytochrome P450 51A1 CYP51A1 0.0064
3760 Penicillin-binding protein 5 precursor dacA 0.0063
2286 Isocitrate dehydrogenase [NADP] icd 0.0063
2302 Isocitrate dehydrogenase [NADP] icd 0.0063
2771 Isocitrate dehydrogenase [NADP] icd 0.0063
1618 High affinity nerve growth factor receptor NTRK1 0.0063
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
133 Dihydropterate synthase sulI 0.0063
5482 Sialidase-2 NEU2 0.0062
1275 Estrogen sulfotransferase SULT1E1 0.0062
614 Progesterone receptor PGR 0.0062
459 Retinoic acid receptor RXR-alpha RXRA 0.0062
432 D(4) dopamine receptor DRD4 0.0062
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0061
4534 Cytohesin-2 CYTH2 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
469 Annexin A1 ANXA1 0.006
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.006
3868 Calcineurin subunit B isoform 2 PPP3R2 0.006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.006
1541 Metalloproteinase mmp20 0.006
2391 Ferrochelatase hemH 0.0059
6502 Ferrochelatase DKFZp686P18130 0.0059
1591 Ferrochelatase, mitochondrial FECH 0.0059
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0059
3856 Fibroblast growth factor receptor 3 FGFR3 0.0059
3668 Maltose-binding periplasmic protein precursor malE 0.0059
5880 Thrombopoietin receptor MPL 0.0058
84 Nuclear receptor 0B1 NR0B1 0.0058
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0058
251 Alcohol dehydrogenase 1A ADH1A 0.0058
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0057
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0057
427 Substance-P receptor TACR1 0.0057
4034 Glutaredoxin-1 GLRX 0.0057
1928 Leukotriene C4 synthase LTC4S 0.0057
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0057
4037 Hypothetical protein GPX1 0.0057
4297 Hypothetical protein SP_1951 0.0057
4521 Hypothetical protein BC_2969 0.0057
4540 Hypothetical protein TM_1070 0.0057
4555 Hypothetical protein MT1739 0.0057
4569 Hypothetical protein mshD 0.0057
4578 Hypothetical protein PA3270 0.0057
4747 Hypothetical protein PA3967 0.0057
5177 Hypothetical protein TM_0096 0.0057
5194 Hypothetical protein PA1204 0.0057
5240 Hypothetical protein Rv2991 0.0057
5370 Hypothetical protein TM_1158 0.0057
5710 Hypothetical protein Tb927.5.1360 0.0057
4029 Microsomal glutathione S-transferase 3 MGST3 0.0057
4032 Microsomal glutathione S-transferase 1 MGST1 0.0057
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0057
4035 Glutathione S-transferase Mu 5 GSTM5 0.0057
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0057
4040 Glutathione peroxidase 7 GPX7 0.0057
910 Epididymal secretory glutathione peroxidase GPX5 0.0057
4036 Glutathione peroxidase 6 GPX6 0.0057
903 Glutathione S-transferase A5 GSTA5 0.0057
906 Glutathione peroxidase 1 GPX1 0.0057
911 Glutathione peroxidase 3 GPX3 0.0057
907 Glutathione peroxidase 2 GPX2 0.0057
4038 Glutathione peroxidase 4 GPX4 0.0057
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0057
900 Glutathione S-transferase A4 GSTA4 0.0057
4042 Glutathione transferase omega-2 GSTO2 0.0057
4033 S-formylglutathione hydrolase ESD 0.0057
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0057
823 Fibroblast growth factor receptor 2 FGFR2 0.0057
6174 50S ribosomal protein L32 rpmF 0.0056
716 5-hydroxytryptamine 7 receptor HTR7 0.0056
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0055
2249 Aspartate aminotransferase aspC 0.0054
2671 Aspartate aminotransferase aspC 0.0054
5490 Aspartate aminotransferase Not Available 0.0054
7 Nitric oxide synthase, inducible NOS2 0.0054
295 Carbonic anhydrase 1 CA1 0.0054
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0054
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0054
2592 Beta-galactosidase lacZ 0.0053
6103 Arylamine N-acetyltransferase 1 NAT1 0.0052
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0052
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0052
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0052
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0052
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0052
6493 Cytochrome c oxidase subunit 6C COX6C 0.0052
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0052
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0052
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0052
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0052
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0052
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0052
6559 Cytochrome c oxidase subunit 2 ctaC 0.0052
6669 Cytochrome c oxidase subunit 2 ctaC 0.0052
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0052
6558 Cytochrome c oxidase subunit 1 ctaD 0.0052
1039 Histone deacetylase 9 HDAC9 0.0051
444 Alcohol dehydrogenase 1B ADH1B 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
5201 FMN-binding protein DvMF_2023 0.0051
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0051
5178 Protein nrdI nrdI 0.0051
5200 NADH dehydrogenase nox 0.0051
5131 PhzG phzG 0.0051
3293 Flavodoxin Not Available 0.0051
4614 Flavodoxin DVU_2680 0.0051
5172 Flavodoxin isiB 0.0051
5173 Flavodoxin isiB 0.0051
5182 Flavodoxin fldA 0.0051
5193 Phenazine biosynthesis protein phzG phzG 0.0051
5198 Flavodoxin-1 fldA 0.0051
5179 Probable aromatic acid decarboxylase pad1 0.0051
5175 Hypothetical protein SMU.260 SMU_260 0.0051
5202 Nitroreductase family protein BC_1844 0.0051
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0051
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0051
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0051
5191 Morphinone reductase morB 0.0051
5190 Rubredoxin-oxygen oxidoreductase roo 0.0051
5181 Hypothetical protein yhdA azr 0.0051
5170 Epidermin decarboxylase epiD 0.0051
4405 Nitric oxide reductase fprA 0.0051
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0051
3319 Hydroxyacylglutathione hydrolase HAGH 0.0051
528 5-hydroxytryptamine 1E receptor HTR1E 0.0051
897 Glutathione S-transferase kappa 1 GSTK1 0.0051
898 Glutathione S-transferase A3 GSTA3 0.005
563 Thyroid peroxidase TPO 0.005
229 Retinoic acid receptor beta RARB 0.005
315 Arginase-1 ARG1 0.005
909 Maleylacetoacetate isomerase GSTZ1 0.005
124 Histamine H2 receptor HRH2 0.005
268 Adenosine A2b receptor ADORA2B 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
2021 Thrombomodulin THBD 0.0049
594 Thyroxine-binding globulin SERPINA7 0.0049
730 Retinoic acid receptor alpha RARA 0.0049
905 Glutathione transferase omega-1 GSTO1 0.0049
899 Glutathione S-transferase Mu 3 GSTM3 0.0049
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0049
672 Prostaglandin F2-alpha receptor PTGFR 0.0049
4041 Microsomal glutathione S-transferase 2 MGST2 0.0048
65 Matrix metalloproteinase-9 Not Available 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0048
5934 Cytochrome P450 26A1 CYP26A1 0.0047
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
2540 Choloylglycine hydrolase cbh 0.0047
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0047
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0047
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0047
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0047
633 Penicillin-binding proteins 1A/1B pbpA 0.0047
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0047
4503 NADPH-flavin oxidoreductase frp 0.0046
5189 Trimethylamine dehydrogenase tmd 0.0046
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0046
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0046
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0046
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0046
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0046
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0046
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0046
867 Penicillin-binding protein 3 pbpC 0.0046
6119 Penicillin-binding protein 3 pbp3 0.0046
7154 Penicillin-binding protein 3 pbp3 0.0046
7157 Penicillin-binding protein 3 LMHCC_2184 0.0046
7162 Penicillin-binding protein 3 pbpB 0.0046
7172 Penicillin-binding protein 3 pbp3 0.0046
737 Mineralocorticoid receptor NR3C2 0.0046
758 Thyroid hormone receptor alpha THRA 0.0045
1656 CYP2B protein CYP2B 0.0045
1654 Interleukin-1 beta IL1B 0.0045
3680 Dihydroorotate dehydrogenase A pyrDA 0.0045
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0045
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0045
332 Beta-lactamase blaZ 0.0045
2478 Beta-lactamase ampC 0.0045
2613 Beta-lactamase ampC 0.0045
2635 Beta-lactamase ampC 0.0045
2700 Beta-lactamase penP 0.0045
5445 Beta-lactamase blaB 0.0045
6019 Beta-lactamase SHV-7 0.0045
6701 Beta-lactamase cphA 0.0045
2165 Glutathione S-transferase Mu 2 GSTM2 0.0044
5176 YtnJ moxC 0.0044
4407 FMN-dependent NADH-azoreductase azoR 0.0044
5169 FMN-dependent NADH-azoreductase azoR 0.0044
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0044
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0044
3507 Chorismate synthase aroC 0.0044
5171 Chorismate synthase aroC 0.0044
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0044
207 Glutathione synthetase GSS 0.0044
5269 Glutathione synthetase gshB 0.0044
49 Endothelin B receptor EDNRB 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0043
1517 Beta-3 adrenergic receptor ADRB3 0.0043
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0042
663 Solute carrier family 12 member 4 SLC12A4 0.0042
53 Solute carrier family 12 member 5 SLC12A5 0.0042
1507 Cytochrome c CYCS 0.0042
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0042
6044 Serum paraoxonase/lactonase 3 PON3 0.0041
901 Glutathione S-transferase Mu 4 GSTM4 0.0041
936 Ephrin type-A receptor 2 EPHA2 0.0041
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0041
2775 Dihydroorotate dehydrogenase pyrD 0.0041
6677 Myelin P2 protein PMP2 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0041
4203 Histamine N-methyltransferase HNMT 0.0041
346 Thyroid hormone receptor beta-1 THRB 0.0041
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0039
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0039
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0039
310 Solute carrier family 12 member 2 SLC12A2 0.0039
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0039
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0039
5180 L(+)-mandelate dehydrogenase mdlB 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0038
163 D(1B) dopamine receptor DRD5 0.0038
6500 Phospholipase A2 PLA2G1B 0.0037
4031 Glutathione S-transferase A1 GSTA1 0.0037
1992 Vitamin D-binding protein GC 0.0037
1629 Transcription factor AP-1 JUN 0.0037
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0037
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0037
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0037
130 Prostacyclin synthase PTGIS 0.0037
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0037
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0036
6432 Transporter snf 0.0036
494 Caspase-1 CASP1 0.0036
2207 Rhodopsin RHO 0.0036
208 DNA-directed RNA polymerase beta' chain rpoC 0.0036
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0036
357 Carbonic anhydrase 2 CA2 0.0036
6268 Hydroxyacid oxidase 1 HAO1 0.0036
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0035
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0035
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0035
592 Carbonic anhydrase 4 CA4 0.0035
1256 5-hydroxytryptamine 6 receptor HTR6 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
3937 Fatty-acid amide hydrolase FAAH 0.0035
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0035
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0034
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0034
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0034
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0034
4284 Pentaerythritol tetranitrate reductase onr 0.0034
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0034
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0034
6168 Solute carrier family 22 member 16 SLC22A16 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
291 Nitric-oxide synthase, endothelial NOS3 0.0034
712 Tubulin alpha chain TUB1 0.0034
4210 Toll-like receptor 4 TLR4 0.0034
1792 Tissue-type plasminogen activator PLAT 0.0034
5122 Mersacidin decarboxylase mrsD 0.0034
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0034
526 Thioredoxin reductase trxB 0.0034
3767 Thioredoxin reductase trxB 0.0034
5095 Putidaredoxin reductase camA 0.0034
3763 5,10-methylenetetrahydrofolate reductase metF 0.0034
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0034
5094 5,10-methylenetetrahydrofolate reductase metF 0.0034
5078 Amine oxidase, flavin-containing PSPTO1126 0.0034
5081 L-aspartate oxidase nadB 0.0034
5111 Phenylacetone monooxygenase pamO 0.0034
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0034
1410 Oxidoreductase HSD17B6 0.0034
4725 Oxidoreductase Not Available 0.0034
5124 Oxidoreductase Not Available 0.0034
5115 FkbI fkbI 0.0034
3133 UDP-galactopyranose mutase glf 0.0034
5099 UDP-galactopyranose mutase glf 0.0034
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0034
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0034
5083 Cryptochrome DASH cry 0.0034
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0034
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0034
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0034
5109 Outer membrane protein p64k or PM-6 m-6 0.0034
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0034
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0033
199 Monocarboxylate transporter 8 SLC16A2 0.0033
1864 RET proto-oncogene RET 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0032
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0032
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0032
3102 Flavohemoprotein hmp 0.0032
4969 Flavohemoprotein hmp 0.0032
232 Corticosteroid-binding globulin SERPINA6 0.0032
461 Glycine receptor subunit alpha-3 GLRA3 0.0032
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0032
595 Fibrinogen alpha chain FGA 0.0032
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0031
719 Retinoic acid receptor responder protein 1 RARRES1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
770 Retinoic acid-induced protein 3 GPRC5A 0.0031
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0031
4486 Phenol 2-hydroxylase component B pheA2 0.0031
4439 Ferredoxin reductase bphA4 0.0031
4477 Dihydrolipoyl dehydrogenase lpdV 0.0031
5077 Dihydrolipoyl dehydrogenase Not Available 0.0031
5117 Dihydrolipoyl dehydrogenase lpd 0.0031
1291 cAMP response element-binding protein CREB1 0.0031
2077 Caspase-3 CASP3 0.003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.003
3594 Deoxyribodipyrimidine photo-lyase phr 0.003
5079 Deoxyribodipyrimidine photo-lyase phrB 0.003
5080 Deoxyribodipyrimidine photo-lyase phr 0.003
173 Toll-like receptor 7 TLR7 0.003
158 Sodium channel protein type 1 subunit alpha SCN1A 0.003
2470 Pyruvate oxidase pox5 0.0029
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0029
5073 Ferredoxin--NADP reductase petH 0.0029
5076 Ferredoxin--NADP reductase fpr 0.0029
5119 Ferredoxin--NADP reductase petH 0.0029
5121 Ferredoxin--NADP reductase fpr 0.0029
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0029
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0029
2526 NADPH-ferredoxin reductase fprA fprA 0.0029
5072 N,N-dimethylglycine oxidase dmg 0.0029
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0029
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0029
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0029
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0029
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0029
2268 Cholesterol oxidase choB 0.0029
2822 Cholesterol oxidase choA 0.0029
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
131 Synaptic vesicular amine transporter SLC18A2 0.0029
6837 Serine/threonine-protein kinase 17B STK17B 0.0028
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
4440 NADH peroxidase npr 0.0028
4311 tRNA TRDMT1 0.0028
4325 tRNA trmD 0.0028
4328 tRNA trmD 0.0028
5431 Lipid binding protein Not Available 0.0028
3616 Fatty acid-binding protein, epidermal FABP5 0.0028
5433 UPF0230 protein TM_1468 TM_1468 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1714 Mitogen-activated protein kinase 3 MAPK3 0.0027
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0027
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0027
474 Acetylcholinesterase ACHE 0.0027
1268 Neuropeptide S receptor NPSR1 0.0027
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0027
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0027
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0027
569 Retinal dehydrogenase 2 ALDH1A2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0027
2893 Glycine oxidase thiO 0.0027
6228 Nuclear receptor coactivator 1 NCOA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
2216 Fibroblast growth factor receptor 4 FGFR4 0.0027
5798 Mitogen-activated protein kinase 11 MAPK11 0.0026
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0026
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
164 Histamine H4 receptor HRH4 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0026
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0026
611 Retinal dehydrogenase 1 ALDH1A1 0.0025
2823 Trypanothione reductase TPR 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
1196 Complement decay-accelerating factor CD55 0.0025
153 Dopamine beta-hydroxylase DBH 0.0025
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0025
327 Glutathione reductase gor 0.0025
5110 Glutathione reductase GR2 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0025
126 D-lactate dehydrogenase dld 0.0025
3545 D-lactate dehydrogenase Not Available 0.0025
4510 D-lactate dehydrogenase ldhA 0.0025
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0025
6073 Potassium channel subfamily K member 9 KCNK9 0.0025
760 Fibroblast growth factor 1 FGF1 0.0025
6072 Potassium channel subfamily K member 3 KCNK3 0.0025
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0024
2769 P-hydroxybenzoate hydroxylase pobA 0.0024
2809 P-hydroxybenzoate hydroxylase pobA 0.0024
1063 Signal transducer and activator of transcription 5B STAT5B 0.0024
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0024
976 Platelet glycoprotein IX GP9 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0024
4102 Proteasome subunit beta type 5 PSMB5 0.0024
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0024
4101 Proteasome subunit beta type 1 PSMB1 0.0024
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0024
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0024
6138 Multidrug resistance protein 3 ABCB4 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
5300 Antigen peptide transporter 1 TAP1 0.0024
6231 Pepsin A PGA3 0.0024
6241 Nuclear receptor coactivator 2 NCOA2 0.0024
6070 Nischarin NISCH 0.0024
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0024
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0024
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0024
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0024
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0024
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0024
2380 Monomeric sarcosine oxidase soxA 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
283 SEC14-like protein 2 SEC14L2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0023
814 Ryanodine receptor 1 RYR1 0.0023
1525 Heparin-binding growth factor 2 FGF2 0.0022
6645 D-amino-acid oxidase DAO 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
6459 Glycodelin PAEP 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
2808 Chloramphenicol acetyltransferase 3 cat3 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
3086 Plasmepsin-2 Not Available 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2599 Tyrosine-protein kinase HCK HCK 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
707 72 kDa type IV collagenase MMP2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.002
6824 Tyrosine-protein kinase Lyn LYN 0.002
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
484 Tyrosine-protein kinase ABL2 ABL2 0.002
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.002
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.002
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
768 FK506-binding protein 1A FKBP1A 0.002
3808 Dihydropteroate synthase 2 folP2 0.002
3601 Dihydropteroate synthase 1 folP1 0.002
3807 Dihydropteroate synthase 1 folP1 0.002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
2417 Chloramphenicol acetyltransferase cat 0.002
3278 Chloramphenicol acetyltransferase cat 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
2810 Dr hemagglutinin structural subunit draA 0.002
1820 Beta-nerve growth factor NGF 0.002
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.002
1058 Cell division protein kinase 5 CDK5 0.002
6164 POU domain, class 5, transcription factor 1 POU5F1 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
822 Aldose reductase AKR1B1 0.002
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0019
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0018
319 Opioid receptor, sigma 1 OPRS1 0.0017
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
828 Phenylalanine-4-hydroxylase PAH 0.0017
3109 Phenylalanine-4-hydroxylase phhA 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0017
2112 Toll-like receptor 9 TLR9 0.0017
1630 Integrin beta-2 ITGB2 0.0017
390 Adenosine A3 receptor ADORA3 0.0016
1243 Cathepsin D CTSD 0.0016
751 Potassium channel subfamily K member 6 KCNK6 0.0016
3830 Calreticulin CALR 0.0016
2499 Tubulin beta-2C chain TUBB2C 0.0015
6034 Hydroxyindole O-methyltransferase ASMT 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6035 Nuclear receptor ROR-beta RORB 0.0015
174 Sigma 1-type opioid receptor SIGMAR1 0.0015
6036 Eosinophil peroxidase EPX 0.0015
172 Potassium channel subfamily K member 1 KCNK1 0.0014
1374 Natriuretic peptides B NPPB 0.0014
6048 Troponin C, skeletal muscle TNNC2 0.0014
1827 Gap junction alpha-1 protein GJA1 0.0014
1908 Vascular cell adhesion protein 1 VCAM1 0.0014
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
856 Vitamin D3 receptor VDR 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
765 Indoleamine 2,3-dioxygenase IDO1 0.0013
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0013
1262 Corticotropin-lipotropin POMC 0.0013
572 Integrin alpha-L ITGAL 0.0013
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0012
820 Glycine receptor subunit alpha-2 GLRA2 0.0012
4948 Cytochrome c-553 Not Available 0.0011
4923 Cytochrome c3 DvMF_2499 0.0011
4945 Cytochrome c3 Not Available 0.0011
4949 Cytochrome c3 DVU_3171 0.0011
4968 Cytochrome c3 cytc3 0.0011
4997 Cytochrome c3 SO_2727 0.0011
5219 Cytochrome c3 cyd 0.0011
4902 Nine-heme cytochrome c Ddes_2038 0.0011
3189 High-molecular-weight cytochrome c hmcA 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
1483 Membrane copper amine oxidase AOC3 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
735 Alanine aminotransferase 1 GPT 0.0009
3904 Alanine aminotransferase 2 GPT2 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
1341 Histamine H3 receptor HRH3 0.0009
3221 Cytochrome c4 cc4 0.0009
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0007
4943 Cytochrome c6 petJ 0.0007
4916 Cyanoglobin glbN 0.0007
4947 Bacterial hemoglobin vhb 0.0007
5000 HemO hemO 0.0007
4934 Cytochrome c-551 nirM 0.0007
5218 Cytochrome c-551 nirM 0.0007
4975 Cytochrome c-556 RPA3973 0.0007
4915 Cytochrome c-550 psbV 0.0007
4959 Cytochrome c-550 psbV 0.0007
5216 Cytochrome c-550 psbV 0.0007
4925 Cytochrome c-type protein SHP shp 0.0007
4942 Diheme cytochrome c napB napB 0.0007
4936 Cytochrome c2 iso-2 Not Available 0.0007
4905 Cytochrome c2 Not Available 0.0007
4939 Cytochrome c2 cycA 0.0007
4964 Cytochrome c2 cycA 0.0007
4979 Cytochrome c2 cycA 0.0007
6673 Cytochrome c2 cycA 0.0007
4994 Hemoglobin-like protein HbO glbO 0.0007
4984 Neuroglobin NGB 0.0007
4981 Iron-starvation protein PigA pigA 0.0007
4998 Hemoglobin-like protein yjbI yjbI 0.0007
4935 Cytochrome c-554 cycA1 0.0007
4961 Hemophore HasA hasA 0.0007
4909 CooA protein cooA 0.0007
4910 Cytoglobin CYGB 0.0007
3116 Bacterioferritin bfr 0.0007
4906 Bacterioferritin bfr 0.0007
4965 Bacterioferritin bfr 0.0007
644 Heme oxygenase 2 HMOX2 0.0007
4982 Heme oxygenase 2 pbsA2 0.0007
4937 Cytochrome oxidase subunit II rcoxA 0.0007
4971 Nonaheme cytochrome c hmcA 0.0007
4904 Cytochrome c family protein GSU1996 0.0007
4907 Cytochrome c-L moxG 0.0007
6865 Cytochrome c-L moxG 0.0007
4989 Cytochrome c551 peroxidase ccp 0.0007
5222 Cytochrome c551 peroxidase ccpA 0.0007
4976 Apocytochrome f petA 0.0007
6407 Apocytochrome f petA 0.0007
4931 Cytochrome P450 167A1 CYP167A1 0.0007
4999 Cytochrome P450 165B3 CYP165B3 0.0007
4903 Methyl-accepting chemotaxis protein Tar4 0.0007
4764 Cytochrome P450 165C4 CYP165C4 0.0007
4960 Putative cytochrome P450-family protein SCO7417 0.0007
4922 Cytochrome c, putative SO_4144 0.0007
4926 Heme-based aerotactic transducer hemAT hemAT 0.0007
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0007
4972 P450cin cinA 0.0007
4993 Hydroxylamine oxidoreductase hao1 0.0007
4952 Catalase/peroxidase katA 0.0007
3093 Catalase HPII katE 0.0007
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0007
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
4920 Peroxidase/catalase katG 0.0005
2119 Cytochrome b5 CYB5A 0.0005
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0005
4990 PpcA ppcA 0.0005
3375 Acidic cytochrome c3 Not Available 0.0005
4988 Sulfite oxidase, mitochondrial SUOX 0.0005
3570 Cytochrome P450 152A1 cypC 0.0005
2915 Sensor protein fixL fixL 0.0005
4944 Sensor protein fixL fixL 0.0005
4385 Cytochrome c' Not Available 0.0005
4967 Cytochrome c' cycA 0.0005
5038 Cytochrome c' Not Available 0.0005
5223 Cytochrome c' cycP 0.0005
4289 Cytochrome P450 TT_P0059 0.0005
6262 Cytochrome P450 staP 0.0005
4813 Heme oxygenase hmuO 0.0005
5769 Heme oxygenase Not Available 0.0005
4992 Cytochrome c peroxidase Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
5961 Insulin INS 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0004
2972 6-deoxyerythronolide B hydroxylase eryF 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
358 Cystathionine beta-synthase CBS 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
693 Hemoglobin subunit beta HBB 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
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