DT-Web

DB00624 - Testosterone


Identification
Name Testosterone
Accession Number DB00624 (APRD00433)
Type small molecule
Description Testosterone is a steroid sex hormone found in both men and women. In men, testosterone is produced primarily by the Leydig (interstitial) cells of the testes when stimulated by luteinizing hormone (LH). It functions to stimulate spermatogenesis, promote physical and functional maturation of spermatozoa, maintain accessory organs of the male reproductive tract, support development of secondary sexual characteristics, stimulate growth and metabolism throughout the body and influence brain development by stimulating sexual behaviors and sexual drive. In women, testosterone is produced by the ovaries (25%), adrenals (25%) and via peripheral conversion from androstenedione (50%). Testerone in women functions to maintain libido and general wellbeing. Testosterone exerts a negative feedback mechanism on pituitary release of LH and follicle-stimulating hormone (FSH). Testosterone may be further converted to dihydrotestosterone or estradiol depending on the tissue.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 288.4244
Groups approved
Monoisotopic Weight 288.20893014
Pharmacology
Indication To be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast in women who are 1-5 years postmenopausal; testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone.
Mechanism of action The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
Absorption Approximately 10% of the testosterone dose applied on the skin surface is absorbed into systemic circulation
Protein binding 40% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound and the rest is bound to albumin and other proteins.
Biotransformation Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT).
Route of elimination About 90% of a dose of testosterone given intramuscularly is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6% of a dose is excreted in the feces, mostly in the unconjugated form.
Toxicity Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The androgen, Testosterone, may incrase the anticoagulant effect of the Vitamin K antagonist, Acenocoumarol. Monitor for changes in the therapeutic effect of Acenocoumarol if Testosterone is initiated, discontinued or dose changed.
Anisindione The androgen may increase the anticoagulant effect of anisindione.
Cyclosporine The androgen, Testosterone, may increase the hepatotoxicity of Cyclosporine. Testosterone may also elevate serum concentrations of Cyclosporine. Consider alternate therapy or monitor for signs of renal and hepatic toxicity.
Dicumarol The androgen may increase the anticoagulant effect of dicumarol.
Docetaxel Testosterone may increase the serum levels and toxicity of docetaxel.
Warfarin Testosterone may increase the serum concentration and anticoagulant effect of warfarin. Monitor for changes in prothrombin time and therapeutic effects of warfarin if testosterone is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Androgen receptor
Name Androgen receptor
Gene Name AR
Pharmacological action yes
Actions agonist
References
  • Small EJ, Ryan CJ: The case for secondary hormonal therapies in the chemotherapy age. J Urol. 2006 Dec;176(6 Pt 2):S66-71. - Pubmed
  • Omwancha J, Brown TR: Selective androgen receptor modulators: in pursuit of tissue-selective androgens. Curr Opin Investig Drugs. 2006 Oct;7(10):873-81. - Pubmed
  • Petraki CD, Sfikas CP: Histopathological changes induced by therapies in the benign prostate and prostate adenocarcinoma. Histol Histopathol. 2007 Jan;22(1):107-18. - Pubmed
  • Maudsley S, Davidson L, Pawson AJ, Freestone SH, Lopez de Maturana R, Thomson AA, Millar RP: Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5. Neuroendocrinology. 2006;84(5):285-300. Epub 2007 Jan 4. - Pubmed
  • Lapauw B, Goemaere S, Crabbe P, Kaufman JM, Ruige JB: Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men? Eur J Endocrinol. 2007 Mar;156(3):395-401. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.2536

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7085
Cytochrome P450 19A1
Name Cytochrome P450 19A1
Gene Name CYP19A1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5908
Cholesterol side-chain cleavage enzyme, mitochondrial
Name Cholesterol side-chain cleavage enzyme, mitochondrial
Gene Name CYP11A1
Actions inhibitor
References
  • Kostic TS, Stojkov NJ, Bjelic MM, Mihajlovic AI, Janjic MM, Andric SA: Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats. Toxicol Sci. 2011 Jun;121(2):397-407. Epub 2011 Apr 6. - Pubmed
DTHybrid score 0.286
Amine oxidase [flavin-containing] A
Name Amine oxidase [flavin-containing] A
Gene Name MAOA
Actions inducer
References
  • Sjoberg RL, Ducci F, Barr CS, Newman TK, Dell'osso L, Virkkunen M, Goldman D: A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior. Neuropsychopharmacology. 2008 Jan;33(2):425-30. Epub 2007 Apr 11. - Pubmed
  • Hoff KM: Interaction of testosterone with monoamineoxidase in mouse brain maturation. Gen Pharmacol. 1977;8(1):55-7. - Pubmed
DTHybrid score 0.4764
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5566
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • (C) Tianyi Zhang, Yongxin Zhu, and Chandrani Gunaratna. Simultaneous Determination of Metabolites from Multiple Cytochrome P450 Probe Substrates by Gradient Liquid Chromatography with UV Detection. - Source
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Zhang T, Zhu Y, Gunaratna C: Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 25;780(2):371-9. - Pubmed
DTHybrid score 1.2789
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4842
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2778
Cytochrome P450 2A13
Name Cytochrome P450 2A13
Gene Name CYP2A13
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1989
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5042
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7634
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6743
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8483
Cytochrome P450 3A43
Name Cytochrome P450 3A43
Gene Name CYP3A43
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2146

Transporters


Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor,inducer
References
  • Lu R, Kanai N, Bao Y, Wolkoff AW, Schuster VL: Regulation of renal oatp mRNA expression by testosterone. Am J Physiol. 1996 Feb;270(2 Pt 2):F332-7. - Pubmed
  • Kanai N, Lu R, Bao Y, Wolkoff AW, Vore M, Schuster VL: Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270(2 Pt 2):F326-31. - Pubmed
  • Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. - Pubmed
DTHybrid score 0.4626
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inducer
References
  • Kobayashi Y, Hirokawa N, Ohshiro N, Sekine T, Sasaki T, Tokuyama S, Endou H, Yamamoto T: Differential gene expression of organic anion transporters in male and female rats. Biochem Biophys Res Commun. 2002 Jan 11;290(1):482-7. - Pubmed
DTHybrid score 0.4204
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions inducer
References
  • Kobayashi Y, Hirokawa N, Ohshiro N, Sekine T, Sasaki T, Tokuyama S, Endou H, Yamamoto T: Differential gene expression of organic anion transporters in male and female rats. Biochem Biophys Res Commun. 2002 Jan 11;290(1):482-7. - Pubmed
DTHybrid score 0.2943
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score 0.4362
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Katoh M, Nakajima M, Yamazaki H, Yokoi T: Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport. Eur J Pharm Sci. 2001 Feb;12(4):505-13. - Pubmed
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
DTHybrid score 0.8784
Sodium/bile acid cotransporter
Name Sodium/bile acid cotransporter
Gene Name SLC10A1
Actions inhibitor
References
  • Schroeder A, Eckhardt U, Stieger B, Tynes R, Schteingart CD, Hofmann AF, Meier PJ, Hagenbuch B: Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. Am J Physiol. 1998 Feb;274(2 Pt 1):G370-5. - Pubmed
DTHybrid score 0.2246
Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions substrate
References
  • Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolic I, Koepsell H, Brockmoller J: The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther. 2009 Sep;86(3):299-306. Epub 2009 Jun 17. - Pubmed
DTHybrid score 0.2767
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions substrate
References
  • Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolic I, Koepsell H, Brockmoller J: The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther. 2009 Sep;86(3):299-306. Epub 2009 Jun 17. - Pubmed
DTHybrid score 0.2576
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Janvilisri T, Venter H, Shahi S, Reuter G, Balakrishnan L, van Veen HW: Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. Epub 2003 Mar 28. - Pubmed
DTHybrid score 0.4323

Carriers


Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions
References Not Available
DTHybrid score 0.4626
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions
References Not Available
DTHybrid score 0.4204
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions
References Not Available
DTHybrid score 0.2943
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions
References Not Available
DTHybrid score 0.4362
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.8784
Sodium/bile acid cotransporter
Name Sodium/bile acid cotransporter
Gene Name SLC10A1
Actions
References Not Available
DTHybrid score 0.2246
Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions
References Not Available
DTHybrid score 0.2767
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions
References Not Available
DTHybrid score 0.2576
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions
References Not Available
DTHybrid score 0.4323

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.6575
4200 Cytochrome P450 1A2 CYP1A2 0.6562
6013 Cytochrome P450 2E1 CYP2E1 0.3452
1729 Solute carrier family 22 member 6 SLC22A6 0.3077
5718 Cytochrome P450 2A6 CYP2A6 0.2977
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.2548
6144 Solute carrier family 22 member 2 SLC22A2 0.2501
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.2473
3939 Amine oxidase [flavin-containing] B MAOB 0.2272
862 Multidrug resistance-associated protein 1 ABCC1 0.2092
776 Bile salt export pump ABCB11 0.2073
118 Organic cation/carnitine transporter 2 SLC22A5 0.2073
20 Prostaglandin G/H synthase 1 PTGS1 0.1943
1024 Solute carrier family 22 member 11 SLC22A11 0.1888
136 Estrogen receptor ESR1 0.1809
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1493
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1479
6106 Cytochrome P450 2C18 CYP2C18 0.1366
2164 Multidrug resistance-associated protein 4 ABCC4 0.1309
290 Prostaglandin G/H synthase 2 PTGS2 0.129
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.126
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1216
871 Glucocorticoid receptor NR3C1 0.1137
824 Sodium-dependent serotonin transporter SLC6A4 0.1137
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.1109
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.1056
869 Estrogen receptor beta ESR2 0.1
614 Progesterone receptor PGR 0.0982
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0979
492 Histamine H1 receptor HRH1 0.0971
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0913
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0904
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0903
556 Alpha-1A adrenergic receptor ADRA1A 0.0901
380 Cytochrome P450 17A1 CYP17A1 0.0848
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0825
713 Sodium-dependent dopamine transporter SLC6A3 0.0785
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0781
6148 Multidrug resistance-associated protein 7 ABCC10 0.0781
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0775
502 5-hydroxytryptamine 2A receptor HTR2A 0.0764
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0732
260 Cytochrome P450 51 ERG11 0.0726
761 Cytochrome P450 51 ERG11 0.0726
3163 Cytochrome P450 51 cyp51 0.0726
468 Cytochrome P450 4A11 CYP4A11 0.0724
318 Alpha-2A adrenergic receptor ADRA2A 0.072
831 D(2) dopamine receptor DRD2 0.071
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0703
3947 Xanthine dehydrogenase/oxidase XDH 0.0681
320 5-hydroxytryptamine 1A receptor HTR1A 0.0668
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0668
6136 Multidrug resistance-associated protein 5 ABCC5 0.0661
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0647
737 Mineralocorticoid receptor NR3C2 0.0643
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0624
731 HIV-1 protease HIV-1 protease 0.0614
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0614
847 Mu-type opioid receptor OPRM1 0.0611
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0607
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0593
3923 Cholinesterase BCHE 0.059
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0569
23 D(1A) dopamine receptor DRD1 0.0566
766 Beta-2 adrenergic receptor ADRB2 0.0561
632 Alpha-1B adrenergic receptor ADRA1B 0.056
817 DNA topoisomerase 2-alpha TOP2A 0.0537
885 5-hydroxytryptamine 1B receptor HTR1B 0.0524
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0518
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0517
193 Beta-1 adrenergic receptor ADRB1 0.0511
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0505
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0505
378 Alpha-2C adrenergic receptor ADRA2C 0.0504
738 Monocarboxylate transporter 1 SLC16A1 0.0502
629 Alpha-2B adrenergic receptor ADRA2B 0.0499
725 5-hydroxytryptamine 1D receptor HTR1D 0.0491
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0489
4604 Liver carboxylesterase 1 CES1 0.0488
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0484
844 Epidermal growth factor receptor EGFR 0.048
381 Prolactin receptor PRLR 0.0477
6137 Multidrug resistance-associated protein 6 ABCC6 0.0474
3810 Catechol O-methyltransferase COMT 0.0466
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0454
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0452
467 Delta-type opioid receptor OPRD1 0.0451
341 5-hydroxytryptamine 3 receptor HTR3A 0.045
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0447
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0442
373 Transthyretin TTR 0.0442
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0441
789 Alpha-1D adrenergic receptor ADRA1D 0.0426
232 Corticosteroid-binding globulin SERPINA6 0.0423
469 Annexin A1 ANXA1 0.0418
696 Kappa-type opioid receptor OPRK1 0.0417
511 5-hydroxytryptamine 1F receptor HTR1F 0.0417
465 Calmodulin CALM1 0.0417
6182 Cytochrome P450 2J2 CYP2J2 0.0406
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0403
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0402
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0396
891 Dihydropteroate synthase folP 0.0395
5359 Dihydropteroate synthase folP 0.0395
7175 Dihydropteroate synthase sulI 0.0395
33 Cystine/glutamate transporter SLC7A11 0.0393
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0393
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0391
226 Gonadotropin-releasing hormone receptor GNRHR 0.0391
4120 NADPH--cytochrome P450 reductase POR 0.0389
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0388
6167 Organic solute transporter subunit beta OSTB 0.0387
6166 Organic solute transporter subunit alpha OSTA 0.0387
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0386
124 Histamine H2 receptor HRH2 0.0384
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0383
6020 Aldehyde oxidase AOX1 0.0382
1757 Myeloperoxidase MPO 0.038
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0374
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0373
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.037
274 Muscarinic acetylcholine receptor M5 CHRM5 0.037
131 Synaptic vesicular amine transporter SLC18A2 0.0367
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0366
590 5-hydroxytryptamine 2C receptor HTR2C 0.0363
29 Tubulin beta-1 chain TUBB1 0.0361
4773 Deoxycytidine kinase DCK 0.0361
450 Muscarinic acetylcholine receptor M4 CHRM4 0.036
504 Mast/stem cell growth factor receptor KIT 0.0359
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0358
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0355
6220 Aryl hydrocarbon receptor AHR 0.035
269 Adrenodoxin, mitochondrial FDX1 0.0348
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0347
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0342
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0342
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0332
122 P2Y purinoceptor 12 P2RY12 0.0326
208 DNA-directed RNA polymerase beta' chain rpoC 0.0326
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0326
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0322
638 D(3) dopamine receptor DRD3 0.032
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0319
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0317
1010 Cytochrome P450 51A1 CYP51A1 0.0316
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.031
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0308
1649 Small inducible cytokine A2 CCL2 0.0299
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0298
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0296
4116 Dihydropteroate synthetase Not Available 0.0296
6085 Fatty acid-binding protein, intestinal FABP2 0.0293
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0287
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0287
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0284
594 Thyroxine-binding globulin SERPINA7 0.0283
6149 Solute carrier family 22 member 10 SLC22A10 0.0283
904 Glutathione S-transferase P GSTP1 0.0281
228 Beta platelet-derived growth factor receptor PDGFRB 0.0281
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0279
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0274
84 Nuclear receptor 0B1 NR0B1 0.0273
1178 Adenosine A2a receptor ADORA2A 0.027
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.027
474 Acetylcholinesterase ACHE 0.0266
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0266
1353 DNA topoisomerase 1 TOP1 0.0264
3552 DNA topoisomerase 1 topA 0.0264
758 Thyroid hormone receptor alpha THRA 0.0263
1656 CYP2B protein CYP2B 0.0261
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0261
244 Angiotensin-converting enzyme ACE 0.026
3587 Gastrotropin FABP6 0.0259
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0256
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0256
338 DNA polymerase UL30 0.0255
379 DNA polymerase UL54 0.0255
697 DNA polymerase ORF28 0.0255
2482 DNA polymerase 43 0.0255
4104 DNA polymerase BALF5 0.0255
4203 Histamine N-methyltransferase HNMT 0.0254
563 Thyroid peroxidase TPO 0.0254
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0253
70 Type-1 angiotensin II receptor AGTR1 0.0252
1517 Beta-3 adrenergic receptor ADRB3 0.0251
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0249
161 Tubulin beta chain TUBB 0.0249
312 Tubulin beta chain TUB2 0.0249
273 Apoptosis regulator Bcl-2 BCL2 0.0248
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0247
558 Solute carrier family 12 member 1 SLC12A1 0.0243
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0242
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0242
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0241
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.024
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.024
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.024
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.024
811 Translocator protein TSPO 0.0237
1852 Microtubule-associated protein 2 MAP2 0.0236
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0236
346 Thyroid hormone receptor beta-1 THRB 0.0236
449 Ornithine decarboxylase ODC1 0.0233
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0232
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0232
2472 Voltage-gated potassium channel kcsA 0.0232
6366 Voltage-gated potassium channel kcsA 0.0232
6151 Monocarboxylate transporter 10 SLC16A10 0.0231
477 DNA topoisomerase 4 subunit A parC 0.0231
886 DNA topoisomerase 4 subunit A parC 0.0231
6226 DNA topoisomerase 4 subunit A parC 0.0231
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0231
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0231
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0231
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0231
6174 50S ribosomal protein L32 rpmF 0.023
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.023
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0228
404 DNA gyrase subunit A gyrA 0.0228
6224 DNA gyrase subunit A gyrA 0.0228
5923 Microtubule-associated protein tau MAPT 0.0228
5924 Microtubule-associated protein 4 MAP4 0.0228
140 30S ribosomal protein S9 rpsI 0.0225
6719 30S ribosomal protein S9 rpsI 0.0225
6725 30S ribosomal protein S9 rpsI 0.0225
5934 Cytochrome P450 26A1 CYP26A1 0.0223
818 50S ribosomal protein L10 rplJ 0.022
16 Adenosine A1 receptor ADORA1 0.022
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0218
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0218
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0218
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0218
26 Vascular endothelial growth factor receptor 3 FLT4 0.0217
407 Vascular endothelial growth factor receptor 2 KDR 0.0217
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0217
777 Tumor necrosis factor TNF 0.0214
7 Nitric oxide synthase, inducible NOS2 0.0214
22 30S ribosomal protein S4 rpsD 0.0214
6714 30S ribosomal protein S4 rpsD 0.0214
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0211
3560 Gentamicin 3'-acetyltransferase aacC1 0.021
5626 Nucleoside diphosphate kinase B NME2 0.021
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.021
183 Vascular endothelial growth factor A VEGFA 0.0208
32 Vascular endothelial growth factor receptor 1 FLT1 0.0208
4122 Histone deacetylase 2 HDAC2 0.0207
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0207
2429 Putrescine-binding periplasmic protein potF 0.0206
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0205
432 D(4) dopamine receptor DRD4 0.0204
1483 Membrane copper amine oxidase AOC3 0.0203
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0203
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0201
3913 Glutamic acid decarboxylase GAD65 0.02
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.02
2539 Tubulin alpha-1 chain TUBA4A 0.0198
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0194
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0194
3809 Estrogen-related receptor gamma ESRRG 0.0193
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0193
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.019
634 Squalene monooxygenase SQLE 0.0188
7196 Squalene monooxygenase ERG1 0.0188
645 Penicillin-binding protein 1A mrcA 0.0187
5805 Penicillin-binding protein 1A ponA 0.0187
6185 Penicillin-binding protein 1A mrcA 0.0187
6799 Penicillin-binding protein 1A pbpA 0.0187
6044 Serum paraoxonase/lactonase 3 PON3 0.0186
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0186
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0186
3917 Methylenetetrahydrofolate reductase MTHFR 0.0185
543 Penicillin-binding protein 1B mrcB 0.0184
6186 Penicillin-binding protein 1B ponB 0.0184
6822 Penicillin-binding protein 1b pbp1b 0.0184
6844 Penicillin-binding protein 1b pbp1b 0.0184
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0183
6146 High affinity copper uptake protein 1 SLC31A1 0.0183
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.018
5126 Arginase rocF 0.0179
1192 Sulfotransferase 1A1 SULT1A1 0.0178
663 Solute carrier family 12 member 4 SLC12A4 0.0178
53 Solute carrier family 12 member 5 SLC12A5 0.0178
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0175
148 Lutropin-choriogonadotropic hormone receptor LHCGR 0.0175
4237 50S ribosomal protein L22 rplV 0.0174
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0174
705 Glutamate receptor 1 GRIA1 0.0173
952 Dipeptidyl peptidase 4 DPP4 0.0173
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0172
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0171
5294 Nucleoside diphosphate kinase A NME1 0.017
4148 Serine/threonine-protein kinase mTOR MTOR 0.0169
4238 50S ribosomal protein L4 rplD 0.0169
5578 50S ribosomal protein L4 rplD 0.0169
6173 50S ribosomal protein L4 rplD 0.0169
6219 50S ribosomal protein L4 rplD 0.0169
6043 Putative G-protein coupled receptor 44 GPR44 0.0169
1389 Transforming growth factor beta-1 TGFB1 0.0169
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0169
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0169
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0168
672 Prostaglandin F2-alpha receptor PTGFR 0.0167
3904 Alanine aminotransferase 2 GPT2 0.0167
735 Alanine aminotransferase 1 GPT 0.0167
482 Glycine receptor subunit alpha-1 GLRA1 0.0166
310 Solute carrier family 12 member 2 SLC12A2 0.0166
6432 Transporter snf 0.0166
976 Platelet glycoprotein IX GP9 0.0165
436 5-hydroxytryptamine 2B receptor HTR2B 0.0165
908 Glutathione S-transferase theta-1 GSTT1 0.0165
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0164
1636 Trace amine-associated receptor 1 TAAR1 0.0164
275 Arachidonate 5-lipoxygenase ALOX5 0.0163
581 Cytochrome P450 2R1 CYP2R1 0.0162
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0161
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0161
1992 Vitamin D-binding protein GC 0.016
571 Melatonin receptor type 1A MTNR1A 0.0159
362 Melatonin receptor type 1B MTNR1B 0.0159
6102 Arylamine N-acetyltransferase 2 NAT2 0.0159
4228 Keratin, type II cytoskeletal 7 KRT7 0.0158
6033 High affinity interleukin-8 receptor A CXCR1 0.0158
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0157
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0157
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0154
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0154
427 Substance-P receptor TACR1 0.0154
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0154
6241 Nuclear receptor coactivator 2 NCOA2 0.0153
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0152
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0152
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0151
716 5-hydroxytryptamine 7 receptor HTR7 0.015
3932 Glutathione S-transferase A2 GSTA2 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
88 Retinoic acid receptor RXR-beta RXRB 0.0149
3957 Adenosine deaminase ADA 0.0149
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0148
24 Thymidylate synthase TMP1 0.0148
359 Thymidylate synthase TYMS 0.0148
2626 Thymidylate synthase thyA 0.0148
2729 Thymidylate synthase thyA 0.0148
5352 Thymidylate synthase THYA 0.0148
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0148
6138 Multidrug resistance protein 3 ABCB4 0.0147
6163 Copper-transporting ATPase 2 ATP7B 0.0147
6165 Copper-transporting ATPase 1 ATP7A 0.0147
284 DNA-directed RNA polymerase beta chain rpoB 0.0146
5773 DNA-directed RNA polymerase beta chain rpoB 0.0146
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0145
150 Cationic amino acid transporter 3 SLC7A3 0.0144
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0144
58 Cationic amino acid transporter 4 SLC7A4 0.0144
199 Monocarboxylate transporter 8 SLC16A2 0.0143
624 Guanidinoacetate N-methyltransferase GAMT 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
303 Diamine acetyltransferase 2 SAT2 0.0141
1317 Spermine synthase SMS 0.0141
623 Spermine oxidase SMOX 0.0141
5353 Glutamate decarboxylase alpha gadA 0.0141
6218 Pannexin-1 PANX1 0.0141
1867 Major prion protein PRNP 0.014
780 Retinoic acid receptor RXR-gamma RXRG 0.014
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.014
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.014
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0138
856 Vitamin D3 receptor VDR 0.0137
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0137
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0136
163 D(1B) dopamine receptor DRD5 0.0136
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0136
165 FL cytokine receptor FLT3 0.0135
3830 Calreticulin CALR 0.0135
342 P protein [Includes: DNA-directed DNA polymerase P 0.0134
612 P protein [Includes: DNA-directed DNA polymerase P 0.0134
365 Dihydrofolate reductase DHFR 0.0134
2381 Dihydrofolate reductase DFR1 0.0134
2833 Dihydrofolate reductase Not Available 0.0134
2931 Dihydrofolate reductase folA 0.0134
3544 Dihydrofolate reductase folA 0.0134
3682 Dihydrofolate reductase folA 0.0134
6642 Dihydrofolate reductase folA 0.0134
6756 Dihydrofolate reductase dfrA 0.0134
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0133
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0133
1618 High affinity nerve growth factor receptor NTRK1 0.0131
164 Histamine H4 receptor HRH4 0.0131
814 Ryanodine receptor 1 RYR1 0.013
1 Peptidoglycan synthetase ftsI ftsI 0.0129
4155 Peptidoglycan synthetase ftsI ftsI 0.0129
2499 Tubulin beta-2C chain TUBB2C 0.0129
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0129
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0129
2449 Tubulin alpha-3 chain TUBA1A 0.0129
633 Penicillin-binding proteins 1A/1B pbpA 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
2981 Phospholipase A2, membrane associated PLA2G2A 0.0128
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0127
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0127
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0127
2300 Lysozyme E 0.0127
3633 Lysozyme R 0.0127
5597 Lysozyme 17 0.0127
123 Diamine acetyltransferase 1 SAT1 0.0127
896 Glutathione S-transferase Mu 1 GSTM1 0.0127
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0126
153 Dopamine beta-hydroxylase DBH 0.0126
537 ATP synthase delta chain, mitochondrial ATP5D 0.0126
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0126
295 Carbonic anhydrase 1 CA1 0.0125
6034 Hydroxyindole O-methyltransferase ASMT 0.0125
6035 Nuclear receptor ROR-beta RORB 0.0125
6036 Eosinophil peroxidase EPX 0.0125
527 Prostacyclin receptor PTGIR 0.0125
6070 Nischarin NISCH 0.0124
823 Fibroblast growth factor receptor 2 FGFR2 0.0124
2183 Fatty acid-binding protein, adipocyte FABP4 0.0124
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0123
174 Sigma 1-type opioid receptor SIGMAR1 0.0123
162 Retinoic acid receptor gamma-1 RARG 0.0123
5787 Angiopoietin-1 receptor TEK 0.0123
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0122
94 5-hydroxytryptamine 4 receptor HTR4 0.0121
6207 30S ribosomal protein S14 rpsN 0.0121
6209 30S ribosomal protein S19 rpsS 0.0121
6712 30S ribosomal protein S19 rpsS 0.0121
6726 30S ribosomal protein S19 rpsS 0.0121
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0121
1629 Transcription factor AP-1 JUN 0.012
768 FK506-binding protein 1A FKBP1A 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0119
68 Cannabinoid receptor 1 CNR1 0.0118
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0118
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0118
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0117
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0117
936 Ephrin type-A receptor 2 EPHA2 0.0116
4217 Telomerase reverse transcriptase TERT 0.0116
751 Potassium channel subfamily K member 6 KCNK6 0.0116
48 Pyridoxal kinase PDXK 0.0116
1714 Mitogen-activated protein kinase 3 MAPK3 0.0116
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
2016 Dipeptidase 1 DPEP1 0.0115
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0114
2211 Fatty acid-binding protein, heart FABP3 0.0114
6168 Solute carrier family 22 member 16 SLC22A16 0.0114
489 Monocarboxylate transporter 2 SLC16A7 0.0113
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0113
221 Lysyl-tRNA synthetase KARS 0.0112
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.011
459 Retinoic acid receptor RXR-alpha RXRA 0.0109
592 Carbonic anhydrase 4 CA4 0.0109
921 Glutamate receptor 2 GRIA2 0.0109
765 Indoleamine 2,3-dioxygenase IDO1 0.0108
887 DNA gyrase subunit B gyrB 0.0108
4150 DNA gyrase subunit B gyrB 0.0108
6225 DNA gyrase subunit B gyrB 0.0108
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0108
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0108
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0107
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0107
6042 Prostaglandin reductase 2 PTGR2 0.0107
528 5-hydroxytryptamine 1E receptor HTR1E 0.0107
115 Penicillin-binding protein 2 mrdA 0.0107
6069 Penicillin-binding protein 2 mrdA 0.0107
6118 Penicillin-binding protein 2 penA 0.0107
6187 Penicillin-binding protein 2 pbpA 0.0107
6686 Penicillin-binding protein 2 pbp2 0.0107
6939 Penicillin-binding protein 2 mrdA 0.0107
7163 Penicillin-binding protein 2 pbpA 0.0107
172 Potassium channel subfamily K member 1 KCNK1 0.0106
357 Carbonic anhydrase 2 CA2 0.0106
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0106
1650 Heme carrier protein 1 SLC46A1 0.0106
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0106
239 Coagulation factor X F10 0.0106
6599 HTH-type transcriptional regulator ttgR ttgR 0.0105
4192 DNA topoisomerase 2-beta TOP2B 0.0105
5698 Riboflavin synthase alpha chain ribE 0.0105
1256 5-hydroxytryptamine 6 receptor HTR6 0.0104
117 Sterol O-acyltransferase 1 SOAT1 0.0104
1050 Bile salt sulfotransferase SULT2A1 0.0104
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0103
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0103
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0102
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0102
408 Riboflavin kinase RFK 0.0101
5682 Ribonuclease pancreatic RNASE1 0.0101
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0101
3685 Catabolite gene activator crp 0.0101
4655 Adenylate cyclase cyaC 0.0101
4759 Adenylate cyclase cyaB2 0.0101
3426 Glutamine synthetase glnA 0.01
3987 Glutamine synthetase GLUL 0.01
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.01
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0099
6171 Solute carrier family 28 member 3 SLC28A3 0.0099
1341 Histamine H3 receptor HRH3 0.0099
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0098
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0097
1630 Integrin beta-2 ITGB2 0.0097
5300 Antigen peptide transporter 1 TAP1 0.0096
49 Endothelin B receptor EDNRB 0.0096
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0096
268 Adenosine A2b receptor ADORA2B 0.0095
566 Serotransferrin TF 0.0094
603 DNA polymerase alpha catalytic subunit POLA1 0.0094
106 Cannabinoid receptor 2 CNR2 0.0094
1569 G1/S-specific cyclin-D1 CCND1 0.0094
319 Opioid receptor, sigma 1 OPRS1 0.0094
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
1063 Signal transducer and activator of transcription 5B STAT5B 0.0093
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0093
992 Protein tyrosine kinase 2 beta PTK2B 0.0092
229 Retinoic acid receptor beta RARB 0.0092
2320 Thymidine kinase, cytosolic TK1 0.0091
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.009
578 Endothelin-1 receptor EDNRA 0.009
730 Retinoic acid receptor alpha RARA 0.009
613 Atrial natriuretic peptide receptor A NPR1 0.009
65 Matrix metalloproteinase-9 Not Available 0.009
2391 Ferrochelatase hemH 0.0089
6502 Ferrochelatase DKFZp686P18130 0.0089
1591 Ferrochelatase, mitochondrial FECH 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0088
1360 Sphingomyelin phosphodiesterase SMPD1 0.0088
2249 Aspartate aminotransferase aspC 0.0087
2671 Aspartate aminotransferase aspC 0.0087
5490 Aspartate aminotransferase Not Available 0.0087
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0087
291 Nitric-oxide synthase, endothelial NOS3 0.0087
461 Glycine receptor subunit alpha-3 GLRA3 0.0086
4760 Mll3241 protein mll3241 0.0086
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0086
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0086
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0086
769 High-affinity choline transporter 1 SLC5A7 0.0086
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0086
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0086
3927 Choline transporter-like protein 3 SLC44A3 0.0086
1686 Choline transporter-like protein 1 SLC44A1 0.0086
3926 Choline transporter-like protein 2 SLC44A2 0.0086
861 Choline kinase alpha CHKA 0.0086
700 Choline dehydrogenase, mitochondrial CHDH 0.0086
576 Choline O-acetyltransferase CHAT 0.0086
3925 Choline transporter-like protein 4 SLC44A4 0.0086
3922 Phospholipase D2 PLD2 0.0086
6501 Fatty acid-binding protein, liver FABP1 0.0086
3924 Phospholipase D1 PLD1 0.0086
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0085
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0085
267 Plasminogen activator inhibitor 1 SERPINE1 0.0084
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0084
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0084
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0083
4311 tRNA TRDMT1 0.0083
4325 tRNA trmD 0.0083
4328 tRNA trmD 0.0083
3760 Penicillin-binding protein 5 precursor dacA 0.0083
1176 Mitogen-activated protein kinase 1 MAPK1 0.0083
1313 Lactoylglutathione lyase GLO1 0.0083
2112 Toll-like receptor 9 TLR9 0.0082
819 Penicillin-binding protein 4 dacB 0.0082
702 UMP-CMP kinase CMPK1 0.0082
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0082
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0082
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0082
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0082
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0081
517 Alcohol dehydrogenase 1C ADH1C 0.0081
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0081
293 Gamma-glutamyl hydrolase GGH 0.008
4210 Toll-like receptor 4 TLR4 0.008
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.008
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.008
1196 Complement decay-accelerating factor CD55 0.008
3856 Fibroblast growth factor receptor 3 FGFR3 0.008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
130 Prostacyclin synthase PTGIS 0.0079
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0078
484 Tyrosine-protein kinase ABL2 ABL2 0.0078
4226 Uridine phosphorylase 2 UPP2 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
1291 cAMP response element-binding protein CREB1 0.0078
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0078
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0078
54 Prothrombin F2 0.0077
820 Glycine receptor subunit alpha-2 GLRA2 0.0077
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0076
6493 Cytochrome c oxidase subunit 6C COX6C 0.0076
6221 Steroid hormone receptor ERR1 ESRRA 0.0076
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0076
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0076
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0076
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0076
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0076
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0076
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0076
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0076
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0076
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0076
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0076
6559 Cytochrome c oxidase subunit 2 ctaC 0.0076
6669 Cytochrome c oxidase subunit 2 ctaC 0.0076
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0076
6558 Cytochrome c oxidase subunit 1 ctaD 0.0076
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0076
6126 Carbonic anhydrase 7 CA7 0.0075
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0075
654 Flavin reductase BLVRB 0.0075
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0074
1541 Metalloproteinase mmp20 0.0074
2236 Casein kinase II subunit alpha CSNK2A1 0.0074
1864 RET proto-oncogene RET 0.0074
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0073
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0073
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
867 Penicillin-binding protein 3 pbpC 0.0073
6119 Penicillin-binding protein 3 pbp3 0.0073
7154 Penicillin-binding protein 3 pbp3 0.0073
7157 Penicillin-binding protein 3 LMHCC_2184 0.0073
7162 Penicillin-binding protein 3 pbpB 0.0073
7172 Penicillin-binding protein 3 pbp3 0.0073
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0072
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0072
4225 Uridine phosphorylase 1 UPP1 0.0072
1654 Interleukin-1 beta IL1B 0.0072
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0071
3937 Fatty-acid amide hydrolase FAAH 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
438 Taste receptor type 1 member 2 TAS1R2 0.0071
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
2540 Choloylglycine hydrolase cbh 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
1039 Histone deacetylase 9 HDAC9 0.007
828 Phenylalanine-4-hydroxylase PAH 0.0069
3109 Phenylalanine-4-hydroxylase phhA 0.0069
2021 Thrombomodulin THBD 0.0069
3639 Thymidine phosphorylase deoA 0.0069
3936 Thymidine phosphorylase TYMP 0.0069
2808 Chloramphenicol acetyltransferase 3 cat3 0.0069
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0069
4103 Proteasome subunit beta type 2 PSMB2 0.0069
4102 Proteasome subunit beta type 5 PSMB5 0.0069
4101 Proteasome subunit beta type 1 PSMB1 0.0069
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0069
1525 Heparin-binding growth factor 2 FGF2 0.0069
2853 14 kDa fatty acid-binding protein Not Available 0.0068
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0068
551 Carnitine O-acetyltransferase CRAT 0.0067
413 Amidophosphoribosyltransferase PPAT 0.0067
2515 Amidophosphoribosyltransferase purF 0.0067
3714 Amidophosphoribosyltransferase purF 0.0067
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
569 Retinal dehydrogenase 2 ALDH1A2 0.0067
5818 Folate receptor alpha FOLR1 0.0067
36 Insulin receptor INSR 0.0066
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0066
144 Hemoglobin subunit alpha HBA1 0.0066
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0066
3686 Acyl-CoA thioesterase I precursor tesA 0.0065
1507 Cytochrome c CYCS 0.0064
3601 Dihydropteroate synthase 1 folP1 0.0063
3807 Dihydropteroate synthase 1 folP1 0.0063
3808 Dihydropteroate synthase 2 folP2 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
719 Retinoic acid receptor responder protein 1 RARRES1 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
572 Integrin alpha-L ITGAL 0.0063
770 Retinoic acid-induced protein 3 GPRC5A 0.0063
133 Dihydropterate synthase sulI 0.0063
611 Retinal dehydrogenase 1 ALDH1A1 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
1275 Estrogen sulfotransferase SULT1E1 0.0062
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0061
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
3611 Cytidine deaminase cdd 0.0059
3707 Cytidine deaminase cdd 0.0059
4211 Cytidine deaminase CDA 0.0059
6103 Arylamine N-acetyltransferase 1 NAT1 0.0059
1405 Thiopurine S-methyltransferase TPMT 0.0059
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0058
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0058
3382 Glycolipid transfer protein GLTP 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
494 Caspase-1 CASP1 0.0058
790 DNA polymerase subunit alpha B POLA2 0.0058
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
499 Arginine decarboxylase ADC 0.0057
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0056
6766 O-GlcNAcase BT_4395 BT_4395 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0055
577 Argininosuccinate lyase ASL 0.0054
6500 Phospholipase A2 PLA2G1B 0.0054
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0054
834 Arginase-2, mitochondrial ARG2 0.0054
6824 Tyrosine-protein kinase Lyn LYN 0.0054
3086 Plasmepsin-2 Not Available 0.0053
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0053
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
1074 Urokinase-type plasminogen activator PLAU 0.0052
518 Peroxidase/catalase T katG 0.0052
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0051
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0051
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
694 Matrix protein 2 M 0.0051
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0051
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0051
5798 Mitogen-activated protein kinase 11 MAPK11 0.0051
740 Argininosuccinate synthase ASS1 0.0051
865 Argininosuccinate synthase ASS1 0.0051
2680 Argininosuccinate synthase argG 0.0051
3194 Argininosuccinate synthase argG 0.0051
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0051
2616 Ganglioside GM2 activator GM2A 0.0051
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0049
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0049
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0049
1141 Sialidase-1 NEU1 0.0049
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0049
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0049
6111 DNA polymerase epsilon subunit 4 POLE4 0.0049
6112 DNA polymerase epsilon subunit 3 POLE3 0.0048
2077 Caspase-3 CASP3 0.0048
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0048
6110 DNA polymerase epsilon subunit 2 POLE2 0.0048
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0048
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0048
1792 Tissue-type plasminogen activator PLAT 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0047
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0047
6677 Myelin P2 protein PMP2 0.0047
1198 Serum paraoxonase/arylesterase 1 PON1 0.0047
6223 Penicillin-binding protein 1C pbpC 0.0047
2216 Fibroblast growth factor receptor 4 FGFR4 0.0047
2268 Cholesterol oxidase choB 0.0047
2822 Cholesterol oxidase choA 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1648 Elastin ELN 0.0046
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0046
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0046
332 Beta-lactamase blaZ 0.0046
2478 Beta-lactamase ampC 0.0046
2613 Beta-lactamase ampC 0.0046
2635 Beta-lactamase ampC 0.0046
2700 Beta-lactamase penP 0.0046
5445 Beta-lactamase blaB 0.0046
6019 Beta-lactamase SHV-7 0.0046
6701 Beta-lactamase cphA 0.0046
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0046
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0046
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0046
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0046
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0045
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0044
6048 Troponin C, skeletal muscle TNNC2 0.0044
251 Alcohol dehydrogenase 1A ADH1A 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
1820 Beta-nerve growth factor NGF 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0044
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0043
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0043
444 Alcohol dehydrogenase 1B ADH1B 0.0043
6131 Carbonic anhydrase 14 CA14 0.0042
1830 5'-nucleotidase NT5E 0.0042
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0042
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0042
125 DNA polymerase beta POLB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
2207 Rhodopsin RHO 0.004
6122 Carbonic anhydrase 3 CA3 0.004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0039
5482 Sialidase-2 NEU2 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
76 Nitric-oxide synthase, brain NOS1 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
1760 Aminopeptidase N ANPEP 0.0038
6843 Aminopeptidase N pepN 0.0038
85 Growth hormone receptor GHR 0.0038
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
2782 Complement C1s subcomponent C1S 0.0037
3616 Fatty acid-binding protein, epidermal FABP5 0.0036
5431 Lipid binding protein Not Available 0.0036
5433 UPF0230 protein TM_1468 TM_1468 0.0036
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0036
6837 Serine/threonine-protein kinase 17B STK17B 0.0035
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0035
509 Thymidine kinase TK 0.0035
570 Thymidine kinase TK 0.0035
2559 Thymidine kinase TK 0.0035
3430 Thymidine kinase tdk 0.0035
3518 Thymidine kinase TK 0.0035
5301 Thymidine kinase tdk 0.0035
5771 Thymidine kinase ORF36 0.0035
7009 Thymidine kinase ORF36 0.0035
939 50S ribosomal protein L3 rplC 0.0035
3815 Complement C1q subcomponent subunit A C1QA 0.0034
3816 Complement C1q subcomponent subunit B C1QB 0.0034
3817 Complement C1q subcomponent subunit C C1QC 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
1374 Natriuretic peptides B NPPB 0.0034
1827 Gap junction alpha-1 protein GJA1 0.0034
1908 Vascular cell adhesion protein 1 VCAM1 0.0034
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0034
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0034
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0034
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0034
3814 Complement C1r subcomponent C1R 0.0034
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0034
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
233 Potassium channel subfamily K member 2 KCNK2 0.0033
6459 Glycodelin PAEP 0.0033
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0033
5880 Thrombopoietin receptor MPL 0.0033
707 72 kDa type IV collagenase MMP2 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
331 Retinol-binding protein I, cellular RBP1 0.0032
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
595 Fibrinogen alpha chain FGA 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.003
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.003
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.003
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.003
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
3007 Carbonic anhydrase 12 CA12 0.003
4205 Carbonic anhydrase 9 CA9 0.003
283 SEC14-like protein 2 SEC14L2 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0029
277 Purine nucleoside phosphorylase PNP 0.0029
2870 Purine nucleoside phosphorylase punA 0.0029
2945 Purine nucleoside phosphorylase punA 0.0029
4659 Purine nucleoside phosphorylase TM_1596 0.0029
4825 Purine nucleoside phosphorylase TTHA1435 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
822 Aldose reductase AKR1B1 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6134 Sodium channel subunit beta-3 SCN3B 0.0027
6133 Sodium channel subunit beta-2 SCN2B 0.0027
6132 Sodium channel subunit beta-1 SCN1B 0.0027
6135 Sodium channel subunit beta-4 SCN4B 0.0027
6127 Carbonic anhydrase-related protein CA8 0.0027
6129 Carbonic anhydrase-related protein 11 CA11 0.0027
6128 Carbonic anhydrase-related protein 10 CA10 0.0027
760 Fibroblast growth factor 1 FGF1 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6228 Nuclear receptor coactivator 1 NCOA1 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
1268 Neuropeptide S receptor NPSR1 0.0025
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0025
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0025
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0024
6130 Carbonic anhydrase 13 CA13 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
6073 Potassium channel subfamily K member 9 KCNK9 0.0023
6072 Potassium channel subfamily K member 3 KCNK3 0.0023
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
6645 D-amino-acid oxidase DAO 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6755 Poliovirus receptor PVR 0.002
1058 Cell division protein kinase 5 CDK5 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
1253 Interferon gamma IFNG 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
173 Toll-like receptor 7 TLR7 0.0016
2297 Genome polyprotein Not Available 0.0016
2322 Genome polyprotein Not Available 0.0016
2694 Genome polyprotein Not Available 0.0016
2719 Genome polyprotein Not Available 0.0016
2860 Genome polyprotein Not Available 0.0016
2928 Genome polyprotein Not Available 0.0016
3160 Genome polyprotein Not Available 0.0016
3260 Genome polyprotein Not Available 0.0016
4783 Genome polyprotein Not Available 0.0016
5726 Genome polyprotein Not Available 0.0016
5779 Genome polyprotein Not Available 0.0016
5867 Genome polyprotein Not Available 0.0016
6253 Genome polyprotein Not Available 0.0016
6301 Genome polyprotein Not Available 0.0016
6380 Genome polyprotein Not Available 0.0016
6381 Genome polyprotein Not Available 0.0016
6437 Genome polyprotein Not Available 0.0016
6520 Genome polyprotein Not Available 0.0016
6521 Genome polyprotein Not Available 0.0016
6652 Genome polyprotein Not Available 0.0016
6734 Genome polyprotein Not Available 0.0016
6735 Genome polyprotein Not Available 0.0016
6736 Genome polyprotein Not Available 0.0016
6737 Genome polyprotein Not Available 0.0016
6738 Genome polyprotein Not Available 0.0016
6739 Genome polyprotein Not Available 0.0016
6744 Genome polyprotein Not Available 0.0016
6748 Genome polyprotein Not Available 0.0016
6894 Genome polyprotein Not Available 0.0016
6898 Genome polyprotein Not Available 0.0016
3221 Cytochrome c4 cc4 0.0015
3233 Bile acid receptor NR1H4 0.0015
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
3102 Flavohemoprotein hmp 0.0015
4969 Flavohemoprotein hmp 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
4948 Cytochrome c-553 Not Available 0.0014
4923 Cytochrome c3 DvMF_2499 0.0014
4945 Cytochrome c3 Not Available 0.0014
4949 Cytochrome c3 DVU_3171 0.0014
4968 Cytochrome c3 cytc3 0.0014
4997 Cytochrome c3 SO_2727 0.0014
5219 Cytochrome c3 cyd 0.0014
4902 Nine-heme cytochrome c Ddes_2038 0.0014
3189 High-molecular-weight cytochrome c hmcA 0.0014
422 Vitamin K-dependent protein C PROC 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
4386 Hemoglobin-like protein HbN glbN 0.0012
997 Protein kinase C beta type PRKCB 0.0012
1295 Fatty acid synthase FASN 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
6859 Protein S100-A4 S100A4 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
798 Osteocalcin BGLAP 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
4954 Soluble cytochrome b558 Not Available 0.0011
4916 Cyanoglobin glbN 0.0011
4943 Cytochrome c6 petJ 0.0011
4925 Cytochrome c-type protein SHP shp 0.0011
4947 Bacterial hemoglobin vhb 0.0011
4915 Cytochrome c-550 psbV 0.0011
4959 Cytochrome c-550 psbV 0.0011
5216 Cytochrome c-550 psbV 0.0011
4994 Hemoglobin-like protein HbO glbO 0.0011
4975 Cytochrome c-556 RPA3973 0.0011
4934 Cytochrome c-551 nirM 0.0011
5218 Cytochrome c-551 nirM 0.0011
4984 Neuroglobin NGB 0.0011
5000 HemO hemO 0.0011
4936 Cytochrome c2 iso-2 Not Available 0.0011
4905 Cytochrome c2 Not Available 0.0011
4939 Cytochrome c2 cycA 0.0011
4964 Cytochrome c2 cycA 0.0011
4979 Cytochrome c2 cycA 0.0011
6673 Cytochrome c2 cycA 0.0011
4981 Iron-starvation protein PigA pigA 0.0011
4942 Diheme cytochrome c napB napB 0.0011
4998 Hemoglobin-like protein yjbI yjbI 0.0011
4910 Cytoglobin CYGB 0.0011
4909 CooA protein cooA 0.0011
4935 Cytochrome c-554 cycA1 0.0011
4961 Hemophore HasA hasA 0.0011
644 Heme oxygenase 2 HMOX2 0.0011
4982 Heme oxygenase 2 pbsA2 0.0011
4907 Cytochrome c-L moxG 0.0011
6865 Cytochrome c-L moxG 0.0011
4971 Nonaheme cytochrome c hmcA 0.0011
4904 Cytochrome c family protein GSU1996 0.0011
4976 Apocytochrome f petA 0.0011
6407 Apocytochrome f petA 0.0011
4931 Cytochrome P450 167A1 CYP167A1 0.0011
4937 Cytochrome oxidase subunit II rcoxA 0.0011
4989 Cytochrome c551 peroxidase ccp 0.0011
5222 Cytochrome c551 peroxidase ccpA 0.0011
4764 Cytochrome P450 165C4 CYP165C4 0.0011
4999 Cytochrome P450 165B3 CYP165B3 0.0011
4903 Methyl-accepting chemotaxis protein Tar4 0.0011
4960 Putative cytochrome P450-family protein SCO7417 0.0011
4972 P450cin cinA 0.0011
4926 Heme-based aerotactic transducer hemAT hemAT 0.0011
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0011
4922 Cytochrome c, putative SO_4144 0.0011
4993 Hydroxylamine oxidoreductase hao1 0.0011
4952 Catalase/peroxidase katA 0.0011
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0011
3093 Catalase HPII katE 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
2298 Cytochrome P450-cam camC 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
369 Coagulation factor VII F7 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
345 Plasma retinol-binding protein RBP4 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.001
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
4439 Ferredoxin reductase bphA4 0.0009
4486 Phenol 2-hydroxylase component B pheA2 0.0009
4477 Dihydrolipoyl dehydrogenase lpdV 0.0009
5077 Dihydrolipoyl dehydrogenase Not Available 0.0009
5117 Dihydrolipoyl dehydrogenase lpd 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
5078 Amine oxidase, flavin-containing PSPTO1126 0.0009
5095 Putidaredoxin reductase camA 0.0009
5122 Mersacidin decarboxylase mrsD 0.0009
526 Thioredoxin reductase trxB 0.0009
3767 Thioredoxin reductase trxB 0.0009
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0009
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5109 Outer membrane protein p64k or PM-6 m-6 0.0009
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0009
5115 FkbI fkbI 0.0009
3133 UDP-galactopyranose mutase glf 0.0009
5099 UDP-galactopyranose mutase glf 0.0009
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0009
5083 Cryptochrome DASH cry 0.0009
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0009
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0009
3763 5,10-methylenetetrahydrofolate reductase metF 0.0009
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0009
5094 5,10-methylenetetrahydrofolate reductase metF 0.0009
5081 L-aspartate oxidase nadB 0.0009
5111 Phenylacetone monooxygenase pamO 0.0009
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0008
3404 Exotoxin A eta 0.0008
4920 Peroxidase/catalase katG 0.0008
2119 Cytochrome b5 CYB5A 0.0008
4990 PpcA ppcA 0.0008
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0008
3375 Acidic cytochrome c3 Not Available 0.0008
4988 Sulfite oxidase, mitochondrial SUOX 0.0008
2915 Sensor protein fixL fixL 0.0008
4944 Sensor protein fixL fixL 0.0008
3570 Cytochrome P450 152A1 cypC 0.0008
4037 Hypothetical protein GPX1 0.0008
4297 Hypothetical protein SP_1951 0.0008
4521 Hypothetical protein BC_2969 0.0008
4540 Hypothetical protein TM_1070 0.0008
4555 Hypothetical protein MT1739 0.0008
4569 Hypothetical protein mshD 0.0008
4578 Hypothetical protein PA3270 0.0008
4747 Hypothetical protein PA3967 0.0008
5177 Hypothetical protein TM_0096 0.0008
5194 Hypothetical protein PA1204 0.0008
5240 Hypothetical protein Rv2991 0.0008
5370 Hypothetical protein TM_1158 0.0008
5710 Hypothetical protein Tb927.5.1360 0.0008
4385 Cytochrome c' Not Available 0.0008
4967 Cytochrome c' cycA 0.0008
5038 Cytochrome c' Not Available 0.0008
5223 Cytochrome c' cycP 0.0008
4813 Heme oxygenase hmuO 0.0008
5769 Heme oxygenase Not Available 0.0008
4289 Cytochrome P450 TT_P0059 0.0008
6262 Cytochrome P450 staP 0.0008
4992 Cytochrome c peroxidase Not Available 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
2230 Catalase CAT 0.0008
3249 Catalase katA 0.0008
3625 Catalase katA 0.0008
4539 Catalase katA 0.0008
4941 Catalase katB 0.0008
4440 NADH peroxidase npr 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
327 Glutathione reductase gor 0.0007
5110 Glutathione reductase GR2 0.0007
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
3594 Deoxyribodipyrimidine photo-lyase phr 0.0007
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0007
5080 Deoxyribodipyrimidine photo-lyase phr 0.0007
5072 N,N-dimethylglycine oxidase dmg 0.0007
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0007
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
2470 Pyruvate oxidase pox5 0.0007
5073 Ferredoxin--NADP reductase petH 0.0007
5076 Ferredoxin--NADP reductase fpr 0.0007
5119 Ferredoxin--NADP reductase petH 0.0007
5121 Ferredoxin--NADP reductase fpr 0.0007
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0007
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0007
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0007
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0007
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0007
2526 NADPH-ferredoxin reductase fprA fprA 0.0007
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0007
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
126 D-lactate dehydrogenase dld 0.0007
3545 D-lactate dehydrogenase Not Available 0.0007
4510 D-lactate dehydrogenase ldhA 0.0007
3411 Cytochrome P450 121 cyp121 0.0007
3670 Soluble cytochrome b562 precursor cybC 0.0007
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0007
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0007
2893 Glycine oxidase thiO 0.0007
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0006
2769 P-hydroxybenzoate hydroxylase pobA 0.0006
2809 P-hydroxybenzoate hydroxylase pobA 0.0006
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0006
2567 Thymidylate synthase thyX thyX 0.0006
2823 Trypanothione reductase TPR 0.0006
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0006
2972 6-deoxyerythronolide B hydroxylase eryF 0.0006
4608 Putative cytochrome P450 SCO1207 0.0006
4963 Putative cytochrome P450 SCO2884 0.0006
6254 Putative cytochrome P450 SCO6998 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2380 Monomeric sarcosine oxidase soxA 0.0006
358 Cystathionine beta-synthase CBS 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
693 Hemoglobin subunit beta HBB 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6749 Polyprotein Not Available 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5961 Insulin INS 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6524 Protein tonB tonB 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
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