DT-Web

DB00822 - Disulfiram


Identification
Name Disulfiram
Accession Number DB00822 (APRD00767)
Type small molecule
Description A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 296.539
Groups approved
Monoisotopic Weight 296.05093141
Pharmacology
Indication For the treatment and management of chronic alcoholism
Mechanism of action Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in the blood producing highly unpleasant symptoms. Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase, which acts in the second step of ethanol utilization. In addition, disulfiram competitively binds and inhibits the peripheral benzodiazepine receptor, which may indicate some value in the treatment of the symptoms of alcohol withdrawal, however this activity has not been extensively studied.
Absorption Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Disulfiram may increase the anticoagulant effect of acenocoumarol.
Aminophylline Disulfiram may increase the effect and toxicity of aminophylline.
Amprenavir Increased irsk of side effects (oral solution)
Anisindione Disulfiram may increase the anticoagulant effect of anisindione.
Chlorzoxazone Disulfiram may increase the serum level of chlorzoxazone by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of chlorzoxazone if diltiazem is initiated, discontinued or dose changed.
Cocaine Increases the cardiac toxicity of cocaine
Dicumarol Disulfiram may increase the anticoagulant effect of dicumarol.
Dyphylline Increases the effect and toxicity of theophylline
Ethotoin Increases the effect of phenytoin
Fosphenytoin Disulfiram may increase the effect of fosphenytoin.
Isoniazid Increased risk of CNS adverse effects
Mephenytoin Increases the effect of phenytoin
Metronidazole Possible acute psychosis and confusion
Oxtriphylline Disulfiram may increase the effect and toxicity of oxtriphylline.
Phenytoin Disulfiram may increase the therapeutic and adverse effects of phenytoin.
Theophylline Disulfiram may increase the effect and toxicity of theophylline.
Tipranavir Disulfiram may cause Tipranavir (Aptivus brand) toxicity by inhibiting alcohol metabolism. Aptivus capsules contain alcohol.
Trimethadione Disulfiram, a strong CYP2E1 inhibitor, may decrease the metabolism and clearance of Trimethadione, a CYP2E1 substrate. Consider alternate therapy or monitor for changes in Trimethadione therapeutic and adverse effects if Disulfiram is initiated, discontinued or dose changed.
Warfarin Disulfiram may increase the anticoagulant effect of warfarin.
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol for up to 14 days after treatment has been stopped.

Targets


Aldehyde dehydrogenase, mitochondrial
Name Aldehyde dehydrogenase, mitochondrial
Gene Name ALDH2
Pharmacological action yes
Actions inhibitor
References
  • Mackenzie IS, Maki-Petaja KM, McEniery CM, Bao YP, Wallace SM, Cheriyan J, Monteith S, Brown MJ, Wilkinson IB: Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans. Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1891-5. Epub 2005 Jul 28. - Pubmed
  • Ho MP, Yo CH, Liu CM, Chen CL, Lee CC: Refractive hypotension in a patient with disulfiram-ethanol reaction. Am J Med Sci. 2007 Jan;333(1):53-5. - Pubmed
DTHybrid score 0.5258
Dopamine beta-hydroxylase
Name Dopamine beta-hydroxylase
Gene Name DBH
Pharmacological action yes
Actions inhibitor
References
  • Gaval-Cruz M, Weinshenker D: mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse. Mol Interv. 2009 Aug;9(4):175-87. - Pubmed
DTHybrid score 0.2522

Enzymes


Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2696
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.344
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5089
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2717

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2006
6016 Cytochrome P450 2C19 CYP2C19 0.1993
4200 Cytochrome P450 1A2 CYP1A2 0.1864
4924 Cytochrome P450 2C8 CYP2C8 0.165
1588 Multidrug resistance protein 1 ABCB1 0.1485
6107 Cytochrome P450 3A7 CYP3A7 0.1471
613 Atrial natriuretic peptide receptor A NPR1 0.1438
6030 Cytochrome P450 2B6 CYP2B6 0.128
563 Thyroid peroxidase TPO 0.0962
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0863
6024 Cytochrome P450 1A1 CYP1A1 0.0815
1757 Myeloperoxidase MPO 0.0731
5718 Cytochrome P450 2A6 CYP2A6 0.0706
20 Prostaglandin G/H synthase 1 PTGS1 0.0591
587 Serum albumin ALB 0.055
6145 Solute carrier family 22 member 1 SLC22A1 0.0379
492 Histamine H1 receptor HRH1 0.0358
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0358
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0357
6144 Solute carrier family 22 member 2 SLC22A2 0.0342
290 Prostaglandin G/H synthase 2 PTGS2 0.034
862 Multidrug resistance-associated protein 1 ABCC1 0.0325
3811 Cytochrome P450 19A1 CYP19A1 0.0324
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0314
6106 Cytochrome P450 2C18 CYP2C18 0.0306
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0299
831 D(2) dopamine receptor DRD2 0.0297
6147 Solute carrier family 22 member 3 SLC22A3 0.0294
118 Organic cation/carnitine transporter 2 SLC22A5 0.0282
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0282
824 Sodium-dependent serotonin transporter SLC6A4 0.0282
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0281
1729 Solute carrier family 22 member 6 SLC22A6 0.0269
1898 Cytochrome P450 1B1 CYP1B1 0.0261
23 D(1A) dopamine receptor DRD1 0.0242
502 5-hydroxytryptamine 2A receptor HTR2A 0.0241
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0237
713 Sodium-dependent dopamine transporter SLC6A3 0.0237
776 Bile salt export pump ABCB11 0.0235
871 Glucocorticoid receptor NR3C1 0.023
6031 Cytochrome P450 3A43 CYP3A43 0.0227
260 Cytochrome P450 51 ERG11 0.0227
761 Cytochrome P450 51 ERG11 0.0227
3163 Cytochrome P450 51 cyp51 0.0227
556 Alpha-1A adrenergic receptor ADRA1A 0.0223
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0222
638 D(3) dopamine receptor DRD3 0.0221
136 Estrogen receptor ESR1 0.0221
6142 Solute carrier family 22 member 8 SLC22A8 0.022
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0216
3941 Amine oxidase [flavin-containing] A MAOA 0.0215
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0205
847 Mu-type opioid receptor OPRM1 0.0204
320 5-hydroxytryptamine 1A receptor HTR1A 0.0198
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0198
341 5-hydroxytryptamine 3 receptor HTR3A 0.0197
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0197
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0196
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0193
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0193
731 HIV-1 protease HIV-1 protease 0.0189
3939 Amine oxidase [flavin-containing] B MAOB 0.0189
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0188
3810 Catechol O-methyltransferase COMT 0.0185
432 D(4) dopamine receptor DRD4 0.0183
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0182
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0181
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0181
318 Alpha-2A adrenergic receptor ADRA2A 0.0179
2164 Multidrug resistance-associated protein 4 ABCC4 0.0172
833 Organic cation/carnitine transporter 1 SLC22A4 0.0172
3839 Phytanoyl-CoA dioxygenase, peroxisomal PHYH 0.0165
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0163
468 Cytochrome P450 4A11 CYP4A11 0.0162
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.016
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0159
590 5-hydroxytryptamine 2C receptor HTR2C 0.0159
632 Alpha-1B adrenergic receptor ADRA1B 0.0156
3954 Egl nine homolog 2 EGLN2 0.0155
3948 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 ALKBH2 0.0155
3956 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKBH3 0.0155
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0155
3946 Hypothetical protein DKFZp686H15154 OGFOD2 0.0155
189 Solute carrier family 23 member 1 SLC23A1 0.0155
3962 Egl nine homolog 3 EGLN3 0.0155
3935 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 PLOD2 0.0155
3966 Putative HIF-prolyl hydroxylase PH-4 P4HTM 0.0155
3953 2-oxoglutarate and iron-dependent oxygenase domain containing 1 OGFOD1 0.0155
3958 Jumonji/ARID domain-containing protein 1D KDM5D 0.0155
467 Delta-type opioid receptor OPRD1 0.0155
6143 Solute carrier family 22 member 7 SLC22A7 0.0152
5126 Arginase rocF 0.0151
740 Argininosuccinate synthase ASS1 0.0149
865 Argininosuccinate synthase ASS1 0.0149
2680 Argininosuccinate synthase argG 0.0149
3194 Argininosuccinate synthase argG 0.0149
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0149
163 D(1B) dopamine receptor DRD5 0.0148
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0147
891 Dihydropteroate synthase folP 0.0141
5359 Dihydropteroate synthase folP 0.0141
7175 Dihydropteroate synthase sulI 0.0141
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.014
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0138
122 P2Y purinoceptor 12 P2RY12 0.0138
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0137
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0137
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0136
696 Kappa-type opioid receptor OPRK1 0.0136
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0135
817 DNA topoisomerase 2-alpha TOP2A 0.0134
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0131
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0131
811 Translocator protein TSPO 0.0131
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.013
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0129
705 Glutamate receptor 1 GRIA1 0.0129
232 Corticosteroid-binding globulin SERPINA6 0.0127
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0126
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0126
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0126
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0126
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0125
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0124
6182 Cytochrome P450 2J2 CYP2J2 0.0124
465 Calmodulin CALM1 0.0124
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0122
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0122
624 Guanidinoacetate N-methyltransferase GAMT 0.0122
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
3943 Peptidyl-glycine alpha-amidating monooxygenase PAM 0.0119
614 Progesterone receptor PGR 0.0119
3960 Egl nine homolog 1 EGLN1 0.0116
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0113
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0113
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0113
766 Beta-2 adrenergic receptor ADRB2 0.0112
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.011
777 Tumor necrosis factor TNF 0.011
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0109
6148 Multidrug resistance-associated protein 7 ABCC10 0.0108
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0107
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0107
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0107
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0106
4116 Dihydropteroate synthetase Not Available 0.0106
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0106
885 5-hydroxytryptamine 1B receptor HTR1B 0.0105
789 Alpha-1D adrenergic receptor ADRA1D 0.0104
6220 Aryl hydrocarbon receptor AHR 0.0102
482 Glycine receptor subunit alpha-1 GLRA1 0.0101
16 Adenosine A1 receptor ADORA1 0.01
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0099
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0099
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0099
4604 Liver carboxylesterase 1 CES1 0.0099
70 Type-1 angiotensin II receptor AGTR1 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
6102 Arylamine N-acetyltransferase 2 NAT2 0.0096
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0096
378 Alpha-2C adrenergic receptor ADRA2C 0.0096
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0096
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0096
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0096
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0096
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0095
629 Alpha-2B adrenergic receptor ADRA2B 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
1024 Solute carrier family 22 member 11 SLC22A11 0.0094
29 Tubulin beta-1 chain TUBB1 0.0094
2485 Hyaluronate lyase SP_0314 0.0093
3172 Hyaluronate lyase hylB 0.0093
6847 Lactase-phlorizin hydrolase LCT 0.0093
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0093
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0092
2245 Xylose isomerase xylA 0.0091
2253 Xylose isomerase xylA 0.0091
2260 Xylose isomerase xylA 0.0091
2431 Xylose isomerase xylA 0.0091
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.009
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0089
5682 Ribonuclease pancreatic RNASE1 0.0088
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0088
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0087
146 Androgen receptor AR 0.0087
295 Carbonic anhydrase 1 CA1 0.0086
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0086
592 Carbonic anhydrase 4 CA4 0.0086
737 Mineralocorticoid receptor NR3C2 0.0086
2300 Lysozyme E 0.0086
3633 Lysozyme R 0.0086
5597 Lysozyme 17 0.0086
1010 Cytochrome P450 51A1 CYP51A1 0.0084
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0084
725 5-hydroxytryptamine 1D receptor HTR1D 0.0084
6137 Multidrug resistance-associated protein 6 ABCC6 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
94 5-hydroxytryptamine 4 receptor HTR4 0.0083
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0082
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0082
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0082
844 Epidermal growth factor receptor EGFR 0.0081
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.008
3923 Cholinesterase BCHE 0.0079
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0078
537 ATP synthase delta chain, mitochondrial ATP5D 0.0077
1178 Adenosine A2a receptor ADORA2A 0.0077
723 Cytosolic phospholipase A2 PLA2G4A 0.0077
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0077
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0075
407 Vascular endothelial growth factor receptor 2 KDR 0.0075
818 50S ribosomal protein L10 rplJ 0.0074
756 Sex hormone-binding globulin SHBG 0.0074
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0074
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0074
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0074
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0074
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0073
6136 Multidrug resistance-associated protein 5 ABCC5 0.0073
3947 Xanthine dehydrogenase/oxidase XDH 0.0073
504 Mast/stem cell growth factor receptor KIT 0.0072
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0071
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0071
251 Alcohol dehydrogenase 1A ADH1A 0.007
444 Alcohol dehydrogenase 1B ADH1B 0.007
49 Endothelin B receptor EDNRB 0.0069
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0069
193 Beta-1 adrenergic receptor ADRB1 0.0068
716 5-hydroxytryptamine 7 receptor HTR7 0.0068
54 Prothrombin F2 0.0067
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0067
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0067
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0066
365 Dihydrofolate reductase DHFR 0.0066
2381 Dihydrofolate reductase DFR1 0.0066
2833 Dihydrofolate reductase Not Available 0.0066
2931 Dihydrofolate reductase folA 0.0066
3544 Dihydrofolate reductase folA 0.0066
3682 Dihydrofolate reductase folA 0.0066
6642 Dihydrofolate reductase folA 0.0066
6756 Dihydrofolate reductase dfrA 0.0066
6020 Aldehyde oxidase AOX1 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
161 Tubulin beta chain TUBB 0.0065
312 Tubulin beta chain TUB2 0.0065
357 Carbonic anhydrase 2 CA2 0.0065
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0065
6014 Cytochrome P450 2A13 CYP2A13 0.0064
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0064
6141 Sodium/bile acid cotransporter SLC10A1 0.0063
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0063
4122 Histone deacetylase 2 HDAC2 0.0063
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0063
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0063
133 Dihydropterate synthase sulI 0.0063
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0062
6126 Carbonic anhydrase 7 CA7 0.0062
869 Estrogen receptor beta ESR2 0.0062
427 Substance-P receptor TACR1 0.0062
814 Ryanodine receptor 1 RYR1 0.0061
952 Dipeptidyl peptidase 4 DPP4 0.0061
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0059
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0058
26 Vascular endothelial growth factor receptor 3 FLT4 0.0057
1656 CYP2B protein CYP2B 0.0056
275 Arachidonate 5-lipoxygenase ALOX5 0.0055
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0055
436 5-hydroxytryptamine 2B receptor HTR2B 0.0055
517 Alcohol dehydrogenase 1C ADH1C 0.0054
228 Beta platelet-derived growth factor receptor PDGFRB 0.0054
32 Vascular endothelial growth factor receptor 1 FLT1 0.0054
823 Fibroblast growth factor receptor 2 FGFR2 0.0054
380 Cytochrome P450 17A1 CYP17A1 0.0054
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0054
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0054
1256 5-hydroxytryptamine 6 receptor HTR6 0.0053
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0053
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0053
124 Histamine H2 receptor HRH2 0.0052
473 L-lactate dehydrogenase A chain LDHA 0.0052
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0052
3932 Glutathione S-transferase A2 GSTA2 0.0052
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0052
239 Coagulation factor X F10 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
768 FK506-binding protein 1A FKBP1A 0.005
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.005
4237 50S ribosomal protein L22 rplV 0.0049
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0049
1483 Membrane copper amine oxidase AOC3 0.0048
921 Glutamate receptor 2 GRIA2 0.0048
1275 Estrogen sulfotransferase SULT1E1 0.0048
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0047
4203 Histamine N-methyltransferase HNMT 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0047
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
2539 Tubulin alpha-1 chain TUBA4A 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
208 DNA-directed RNA polymerase beta' chain rpoC 0.0046
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0046
527 Prostacyclin receptor PTGIR 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
474 Acetylcholinesterase ACHE 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
2230 Catalase CAT 0.0044
3249 Catalase katA 0.0044
3625 Catalase katA 0.0044
4539 Catalase katA 0.0044
4941 Catalase katB 0.0044
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0044
284 DNA-directed RNA polymerase beta chain rpoB 0.0044
5773 DNA-directed RNA polymerase beta chain rpoB 0.0044
6138 Multidrug resistance protein 3 ABCB4 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0043
183 Vascular endothelial growth factor A VEGFA 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
477 DNA topoisomerase 4 subunit A parC 0.0042
886 DNA topoisomerase 4 subunit A parC 0.0042
6226 DNA topoisomerase 4 subunit A parC 0.0042
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0042
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0042
404 DNA gyrase subunit A gyrA 0.0042
6224 DNA gyrase subunit A gyrA 0.0042
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0042
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0041
3601 Dihydropteroate synthase 1 folP1 0.0041
3807 Dihydropteroate synthase 1 folP1 0.0041
3808 Dihydropteroate synthase 2 folP2 0.0041
856 Vitamin D3 receptor VDR 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
4120 NADPH--cytochrome P450 reductase POR 0.004
738 Monocarboxylate transporter 1 SLC16A1 0.004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.004
780 Retinoic acid receptor RXR-gamma RXRG 0.004
904 Glutathione S-transferase P GSTP1 0.0039
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
1541 Metalloproteinase mmp20 0.0039
373 Transthyretin TTR 0.0039
528 5-hydroxytryptamine 1E receptor HTR1E 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
518 Peroxidase/catalase T katG 0.0039
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
569 Retinal dehydrogenase 2 ALDH1A2 0.0038
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0037
1852 Microtubule-associated protein 2 MAP2 0.0037
1192 Sulfotransferase 1A1 SULT1A1 0.0037
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
6085 Fatty acid-binding protein, intestinal FABP2 0.0036
88 Retinoic acid receptor RXR-beta RXRB 0.0036
611 Retinal dehydrogenase 1 ALDH1A1 0.0036
319 Opioid receptor, sigma 1 OPRS1 0.0036
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0036
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0036
165 FL cytokine receptor FLT3 0.0036
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0036
3404 Exotoxin A eta 0.0036
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0035
84 Nuclear receptor 0B1 NR0B1 0.0035
5300 Antigen peptide transporter 1 TAP1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
469 Annexin A1 ANXA1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
3809 Estrogen-related receptor gamma ESRRG 0.0035
976 Platelet glycoprotein IX GP9 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
1618 High affinity nerve growth factor receptor NTRK1 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
24 Thymidylate synthase TMP1 0.0034
359 Thymidylate synthase TYMS 0.0034
2626 Thymidylate synthase thyA 0.0034
2729 Thymidylate synthase thyA 0.0034
5352 Thymidylate synthase THYA 0.0034
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0034
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0034
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0034
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0034
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0034
4238 50S ribosomal protein L4 rplD 0.0033
5578 50S ribosomal protein L4 rplD 0.0033
6173 50S ribosomal protein L4 rplD 0.0033
6219 50S ribosomal protein L4 rplD 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
6174 50S ribosomal protein L32 rpmF 0.0033
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0033
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0033
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0032
1196 Complement decay-accelerating factor CD55 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
3086 Plasmepsin-2 Not Available 0.0032
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
3937 Fatty-acid amide hydrolase FAAH 0.0031
4311 tRNA TRDMT1 0.0031
4325 tRNA trmD 0.0031
4328 tRNA trmD 0.0031
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0031
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3913 Glutamic acid decarboxylase GAD65 0.0031
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0031
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0031
174 Sigma 1-type opioid receptor SIGMAR1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
1050 Bile salt sulfotransferase SULT2A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
908 Glutathione S-transferase theta-1 GSTT1 0.003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.003
273 Apoptosis regulator Bcl-2 BCL2 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
5923 Microtubule-associated protein tau MAPT 0.003
4192 DNA topoisomerase 2-beta TOP2B 0.0029
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0029
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
4773 Deoxycytidine kinase DCK 0.0028
33 Cystine/glutamate transporter SLC7A11 0.0028
2808 Chloramphenicol acetyltransferase 3 cat3 0.0028
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0028
2298 Cytochrome P450-cam camC 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0028
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
1650 Heme carrier protein 1 SLC46A1 0.0027
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0027
816 Biliverdin reductase A BLVRA 0.0027
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0027
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0026
3904 Alanine aminotransferase 2 GPT2 0.0026
735 Alanine aminotransferase 1 GPT 0.0026
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0026
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
1629 Transcription factor AP-1 JUN 0.0025
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0025
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0025
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0025
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
2112 Toll-like receptor 9 TLR9 0.0025
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0025
1648 Elastin ELN 0.0024
646 Malate dehydrogenase, cytoplasmic MDH1 0.0024
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0024
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0024
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0024
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0024
597 Dihydropteridine reductase QDPR 0.0024
396 Alcohol dehydrogenase 4 ADH4 0.0024
328 Sorbitol dehydrogenase SORD 0.0024
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0024
358 Cystathionine beta-synthase CBS 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0024
3917 Methylenetetrahydrofolate reductase MTHFR 0.0024
634 Squalene monooxygenase SQLE 0.0024
7196 Squalene monooxygenase ERG1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1374 Natriuretic peptides B NPPB 0.0024
2981 Phospholipase A2, membrane associated PLA2G2A 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0024
164 Histamine H4 receptor HRH4 0.0023
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0023
6146 High affinity copper uptake protein 1 SLC31A1 0.0023
131 Synaptic vesicular amine transporter SLC18A2 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0023
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0023
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0023
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0023
12 Alcohol dehydrogenase class 3 ADH5 0.0023
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0023
581 Cytochrome P450 2R1 CYP2R1 0.0023
7 Nitric oxide synthase, inducible NOS2 0.0022
77 L-lactate dehydrogenase B chain LDHB 0.0022
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0022
5787 Angiopoietin-1 receptor TEK 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0022
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
2232 Interleukin-5 IL5 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
2449 Tubulin alpha-3 chain TUBA1A 0.0021
1630 Integrin beta-2 ITGB2 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0021
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0021
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
3191 Histidinol dehydrogenase hisD 0.0021
1353 DNA topoisomerase 1 TOP1 0.0021
3552 DNA topoisomerase 1 topA 0.0021
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0021
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.002
166 NAD-dependent malic enzyme, mitochondrial ME2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
820 Glycine receptor subunit alpha-2 GLRA2 0.002
268 Adenosine A2b receptor ADORA2B 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
6432 Transporter snf 0.002
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0019
1525 Heparin-binding growth factor 2 FGF2 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
4423 Levodione reductase lvr 0.0019
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0019
4428 Redox-sensing transcriptional repressor rex rex 0.0019
4447 Hypothetical protein yhfP yhfP 0.0019
4449 ADP-ribosyltransferase Not Available 0.0019
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0019
4455 Glycerol dehydrogenase gldA 0.0019
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0019
4435 L-aspartate dehydrogenase nadX 0.0019
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0019
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0019
4487 Transcriptional regulator nadR nadR 0.0019
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0019
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0019
4500 L-lactate dehydrogenase 2 ldh2 0.0019
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0019
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0019
3381 Alcohol dehydrogenase Not Available 0.0019
4508 Alcohol dehydrogenase adhA 0.0019
4414 Dehydrogenase TT_P0035 0.0019
2350 3-isopropylmalate dehydrogenase leuB 0.0019
3092 3-isopropylmalate dehydrogenase leuB 0.0019
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0019
4418 AGR_L_3209p AGR_L_3209 0.0019
4507 Alanine dehydrogenase ald 0.0019
4443 Quinate/shikimate dehydrogenase ydiB 0.0019
4497 Benzyl alcohol dehydrogenase xylB 0.0019
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0019
4502 Formate dehydrogenase Not Available 0.0019
3729 Citrate synthase gltA 0.0019
4575 Citrate synthase cit 0.0019
4580 Citrate synthase gltA 0.0019
4451 Vip2Ac vip2Ac 0.0019
4472 Glucose 1-dehydrogenase Not Available 0.0019
4467 Alpha-glucosidase, putative TM_0752 0.0019
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0019
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
896 Glutathione S-transferase Mu 1 GSTM1 0.0019
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0018
719 Retinoic acid receptor responder protein 1 RARRES1 0.0018
770 Retinoic acid-induced protein 3 GPRC5A 0.0018
712 Tubulin alpha chain TUB1 0.0018
936 Ephrin type-A receptor 2 EPHA2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
683 Potassium transporter GK0582 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6044 Serum paraoxonase/lactonase 3 PON3 0.0017
1517 Beta-3 adrenergic receptor ADRB3 0.0017
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0017
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
106 Cannabinoid receptor 2 CNR2 0.0017
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
1268 Neuropeptide S receptor NPSR1 0.0017
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0017
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0017
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0017
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0017
714 Glutathione reductase, mitochondrial GSR 0.0017
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0017
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0017
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0016
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
572 Integrin alpha-L ITGAL 0.0016
6149 Solute carrier family 22 member 10 SLC22A10 0.0016
3856 Fibroblast growth factor receptor 3 FGFR3 0.0016
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0016
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0016
173 Toll-like receptor 7 TLR7 0.0016
267 Plasminogen activator inhibitor 1 SERPINE1 0.0016
751 Potassium channel subfamily K member 6 KCNK6 0.0016
1864 RET proto-oncogene RET 0.0016
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0016
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0016
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0016
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
3221 Cytochrome c4 cc4 0.0015
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0015
4486 Phenol 2-hydroxylase component B pheA2 0.0015
4439 Ferredoxin reductase bphA4 0.0015
4477 Dihydrolipoyl dehydrogenase lpdV 0.0015
5077 Dihydrolipoyl dehydrogenase Not Available 0.0015
5117 Dihydrolipoyl dehydrogenase lpd 0.0015
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0015
4427 TDP-glucose-4,6-dehydratase desIV 0.0015
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0015
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0015
4503 NADPH-flavin oxidoreductase frp 0.0015
4482 UDP-galactose 4-epimerase galE 0.0015
2967 CDP-paratose 2-epimerase rfbE 0.0015
2507 Diphtheria toxin Not Available 0.0015
2538 6-phospho-beta-glucosidase bglT bglT 0.0015
2393 Maltose-6'-phosphate glucosidase glvA 0.0015
2018 Deoxyhypusine synthase DHPS 0.0015
4509 Acetoin(diacetyl) reductase budC 0.0015
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0015
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0015
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0015
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0015
3081 3-dehydroquinate synthase aroB 0.0015
126 D-lactate dehydrogenase dld 0.0015
3545 D-lactate dehydrogenase Not Available 0.0015
4510 D-lactate dehydrogenase ldhA 0.0015
2591 Urocanate hydratase hutU 0.0015
3615 Dihydrodipicolinate reductase dapB 0.0015
3618 Dihydrodipicolinate reductase dapB 0.0015
4462 Dihydrodipicolinate reductase dapB 0.0015
4498 Ornithine cyclodeaminase PP3533 0.0015
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0015
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0015
2424 L-lactate dehydrogenase ldh 0.0015
2641 L-lactate dehydrogenase Not Available 0.0015
4437 L-lactate dehydrogenase ldh 0.0015
4442 L-lactate dehydrogenase ldh 0.0015
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0015
4450 Iota toxin component Ia Not Available 0.0015
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0015
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0015
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0015
4496 C-terminal-binding protein 1 CTBP1 0.0015
2336 2,3-diketo-L-gulonate reductase dlgD 0.0015
1341 Histamine H3 receptor HRH3 0.0014
172 Potassium channel subfamily K member 1 KCNK1 0.0014
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0014
5934 Cytochrome P450 26A1 CYP26A1 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
2683 Mono-ADP-ribosyltransferase C3 C3 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0014
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1039 Histone deacetylase 9 HDAC9 0.0014
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0014
2216 Fibroblast growth factor receptor 4 FGFR4 0.0014
6163 Copper-transporting ATPase 2 ATP7B 0.0014
6165 Copper-transporting ATPase 1 ATP7A 0.0014
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0014
4476 Mannitol dehydrogenase mtlD 0.0014
63 Malate dehydrogenase mdh 0.0014
2329 Malate dehydrogenase mdh 0.0014
3445 Malate dehydrogenase mdh 0.0014
4420 Malate dehydrogenase mdh 0.0014
4438 Malate dehydrogenase mdh 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0013
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0013
3957 Adenosine deaminase ADA 0.0013
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
4504 WbpP Not Available 0.0013
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0013
3367 GDP-mannose 6-dehydrogenase algD 0.0013
4318 Siroheme synthase cysG 0.0013
4440 NADH peroxidase npr 0.0013
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0013
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0013
4343 Alpha-glucosidase aglA 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0013
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0012
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0012
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0012
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0012
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0012
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0012
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0012
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0012
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0012
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0012
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0012
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0012
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0012
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0012
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0012
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0012
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0012
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0012
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0012
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0012
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0012
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0012
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0012
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0012
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0012
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0012
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0012
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0012
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0012
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0012
644 Heme oxygenase 2 HMOX2 0.0012
4982 Heme oxygenase 2 pbsA2 0.0012
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0012
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0012
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0012
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0012
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0012
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0012
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0012
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0012
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0012
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0012
327 Glutathione reductase gor 0.0012
5110 Glutathione reductase GR2 0.0012
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0012
107 C-4 methylsterol oxidase SC4MOL 0.0012
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0012
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0012
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0012
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0012
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0012
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0012
729 GDP-L-fucose synthetase TSTA3 0.0012
3463 GDP-L-fucose synthetase fcl 0.0012
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0012
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0012
167 L-lactate dehydrogenase C chain LDHC 0.0012
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0012
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0012
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0012
3726 D-3-phosphoglycerate dehydrogenase serA 0.0012
4291 D-3-phosphoglycerate dehydrogenase serA 0.0012
206 3-keto-steroid reductase HSD17B7 0.0012
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0012
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0012
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0012
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0012
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0012
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0012
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0012
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0012
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0012
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0012
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0012
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0012
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0012
34 7-dehydrocholesterol reductase DHCR7 0.0012
711 UDP-glucose 6-dehydrogenase UGDH 0.0012
3672 UDP-glucose 6-dehydrogenase hasB 0.0012
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0012
643 Peroxisomal bifunctional enzyme EHHADH 0.0012
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0012
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0012
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0012
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0012
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0012
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0012
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
2826 Glucose--fructose oxidoreductase gfo 0.0012
1295 Fatty acid synthase FASN 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
3070 Adenosylhomocysteinase AHCY 0.0012
4424 Adenosylhomocysteinase PFE1050w 0.0012
6278 Adenosylhomocysteinase ahcY 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0012
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0012
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0012
1992 Vitamin D-binding protein GC 0.0012
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0012
666 NADP-dependent malic enzyme ME1 0.0012
162 Retinoic acid receptor gamma-1 RARG 0.0012
2207 Rhodopsin RHO 0.0011
857 Malate dehydrogenase, mitochondrial MDH2 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2236 Casein kinase II subunit alpha CSNK2A1 0.0011
4103 Proteasome subunit beta type 2 PSMB2 0.0011
4101 Proteasome subunit beta type 1 PSMB1 0.0011
4102 Proteasome subunit beta type 5 PSMB5 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0011
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0011
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
2286 Isocitrate dehydrogenase [NADP] icd 0.0011
2302 Isocitrate dehydrogenase [NADP] icd 0.0011
2771 Isocitrate dehydrogenase [NADP] icd 0.0011
4491 DNA ligase, NAD-dependent ligA 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.0011
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0011
3673 Fumarate reductase flavoprotein subunit fccA 0.0011
4912 Fumarate reductase flavoprotein subunit ifcA 0.0011
6549 Fumarate reductase flavoprotein subunit frdA 0.0011
4217 Telomerase reverse transcriptase TERT 0.0011
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0011
6026 Alcohol dehydrogenase 6 ADH6 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
627 11-cis retinol dehydrogenase RDH5 0.001
626 Cysteine dioxygenase type 1 CDO1 0.001
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.001
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.001
2762 UDP-glucose 4-epimerase GALE 0.001
3461 UDP-glucose 4-epimerase galE 0.001
291 Nitric-oxide synthase, endothelial NOS3 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
511 5-hydroxytryptamine 1F receptor HTR1F 0.001
13 Aminomethyltransferase, mitochondrial AMT 0.001
3007 Carbonic anhydrase 12 CA12 0.001
4205 Carbonic anhydrase 9 CA9 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
810 Heme oxygenase 1 HMOX1 0.001
3391 Heme oxygenase 1 pbsA1 0.001
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.001
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
654 Flavin reductase BLVRB 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
279 Tyrosinase TYR 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0009
798 Osteocalcin BGLAP 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6459 Glycodelin PAEP 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
369 Coagulation factor VII F7 0.0008
1867 Major prion protein PRNP 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
6218 Pannexin-1 PANX1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
2802 Endoglucanase G celCCG 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
822 Aldose reductase AKR1B1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
125 DNA polymerase beta POLB 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1507 Cytochrome c CYCS 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
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