DT-Web

DB00907 - Cocaine


Identification
Name Cocaine
Accession Number DB00907 (APRD00080)
Type small molecule
Description An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 303.3529
Groups illicit
Monoisotopic Weight 303.147058165
Pharmacology
Indication For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
Mechanism of action Cocaine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by reversibly binding to and inactivating sodium channels. Sodium influx through these channels is necessary for the depolarization of nerve cell membranes and subsequent propagation of impulses along the course of the nerve. Cocaine is the only local anesthetic with vasoconstrictive properties. This is a result of its blockade of norepinephrine reuptake in the autonomic nervous system. Cocaine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. Its effect on dopamine levels is most responsible for the addictive property of cocaine.
Absorption Cocaine is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. By oral or intra-nasal route, 60 to 80% of cocaine is absorbed.
Protein binding Not Available
Biotransformation Hepatic. Cocaine is metabolized to benzoylecgonine and ecgonine methyl ester, which are both excreted in the urine. In the presence of alcohol, a further active metabolite, cocaethylene is formed, and is more toxic then cocaine itself.
Route of elimination Not Available
Toxicity Intense agitation, convulsions, hypertension, rhythm disturbance, coronary insufficiency, hyperthermia, rhabdomyolysis, and renal impairment. Oral mouse LD50 = 96 mg/kg
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Atomoxetine CYP2D6 Inhibitors (Strong) such as cocaine may increase the serum concentration of atomoxetine. Initiate atomoxetine at a reduced dose (patients up to 70kg: 0.5mg/kg/day; patients 70kg or more: 40mg/day) in patients receiving a strong CYP2D6 inhibitor. The dose should only be increased to usual doses if symptoms fail to improve after 4 weeks. Patients established on atomoxetine therapy may require dosage reductions and should be monitored for increased levels/adverse effects with initiation/dose increase of a strong CYP2D6 inhibitor.
Disulfiram Increases the cardiac toxicity of cocaine
Iloperidone CYP2D6 Inhibitors (Strong) such as cocaine may increase serum concentrations of the active metabolite(s) of Iloperidone. Specifically, concentrations of the metabolite P88 may be increased. CYP2D6 Inhibitors (Strong) may decrease serum concentrations of the active metabolite(s) of Iloperidone. Specifically, concentrations of the metabolite P95 may be decreased. CYP2D6 Inhibitors (Strong) may increase the serum concentration of Iloperidone. Reduce iloperidone dose by half when administered with a strong CYP2D6 inhibitor.
Iobenguane Sympathomimetic that increase chances of producing a false negative imaging result
Tamoxifen Cocaine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Tamsulosin Cocaine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Cocaine is initiated, discontinued, or dose changed.
Telithromycin Telithromycin may reduce clearance of Cocaine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cocaine if Telithromycin is initiated, discontinued or dose changed.
Tetrabenazine CYP2D6 Inhibitors (Strong) such as cocaine may increase the serum concentration of tetrabenazine. Specifically, concentrations of the active alpha- and beta-dihydrotetrabenazine metabolites may be increased. Patients receiving a strong inhibitor of CYP2D6 together with tetrabenazine should not exceed 50mg of tetrabenazine. Also, patients already taking tetrabenazine prior to starting a strong CYP2D6 inhibitor should have their tetrabenazine dose reduced by 50% upon initiation of the strong CYP2D6 inhibitor.
Tolterodine Cocaine may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Tramadol Cocaine may decrease the effect of Tramadol by decreasing active metabolite production.
Trimipramine The strong CYP2D6 inhibitor, Cocaine, may decrease the metabolism and clearance of Trimipramine, a CYP2D6 substrate.
Venlafaxine Cocaine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Cocaine is initiated, discontinued, or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of cocaine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of cocaine if voriconazole is initiated, discontinued or dose changed.
Zuclopenthixol Cocaine, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if cocaine is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Sodium-dependent dopamine transporter
Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Pharmacological action yes
Actions inhibitor
References
  • Wilson JM, Levey AI, Bergeron C, Kalasinsky K, Ang L, Peretti F, Adams VI, Smialek J, Anderson WR, Shannak K, Deck J, Niznik HB, Kish SJ: Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users. Ann Neurol. 1996 Sep;40(3):428-39. - Pubmed
  • Kim DI, Schweri MM, Deutsch HM: Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors. J Med Chem. 2003 Apr 10;46(8):1456-64. - Pubmed
  • Rothman RB, Baumann MH, Dersch CM, Appel J, Houghten RA: Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library. Synapse. 1999 Sep 1;33(3):239-46. - Pubmed
  • Carrera MR, Meijler MM, Janda KD: Cocaine pharmacology and current pharmacotherapies for its abuse. Bioorg Med Chem. 2004 Oct 1;12(19):5019-30. - Pubmed
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.6241
Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action yes
Actions inhibitor
References
  • Galli A, DeFelice LJ, Duke BJ, Moore KR, Blakely RD: Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants. J Exp Biol. 1995 Oct;198(Pt 10):2197-212. - Pubmed
  • Burchett SA, Bannon MJ: Serotonin, dopamine and norepinephrine transporter mRNAs: heterogeneity of distribution and response to 'binge' cocaine administration. Brain Res Mol Brain Res. 1997 Oct 3;49(1-2):95-102. - Pubmed
  • Zhao Y, Sun L: Perinatal cocaine exposure reduces myocardial norepinephrine transporter function in the neonatal rat. Neurotoxicol Teratol. 2004 May-Jun;26(3):443-50. - Pubmed
  • Carrera MR, Meijler MM, Janda KD: Cocaine pharmacology and current pharmacotherapies for its abuse. Bioorg Med Chem. 2004 Oct 1;12(19):5019-30. - Pubmed
DTHybrid score 0.6766
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action yes
Actions inhibitor
References
  • Patkar AA, Berrettini WH, Hoehe M, Thornton CC, Gottheil E, Hill K, Weinstein SP: Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals. Psychiatry Res. 2002 Jun 1;110(2):103-15. - Pubmed
  • Barker EL, Moore KR, Rakhshan F, Blakely RD: Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter. J Neurosci. 1999 Jun 15;19(12):4705-17. - Pubmed
  • Corey JL, Quick MW, Davidson N, Lester HA, Guastella J: A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization. Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1188-92. - Pubmed
  • Carrera MR, Meijler MM, Janda KD: Cocaine pharmacology and current pharmacotherapies for its abuse. Bioorg Med Chem. 2004 Oct 1;12(19):5019-30. - Pubmed
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.5198
Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Antzelevitch C: Brugada syndrome. Pacing Clin Electrophysiol. 2006 Oct;29(10):1130-59. - Pubmed
  • Satish OS, Yeh KH, Wen MS: Brugada syndrome--an update. Chang Gung Med J. 2005 Feb;28(2):69-76. - Pubmed
  • Wright SN, Wang SY, Xiao YF, Wang GK: State-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit. Biophys J. 1999 Jan;76(1 Pt 1):233-45. - Pubmed
DTHybrid score 0.5982
Sodium channel protein type 11 subunit alpha
Name Sodium channel protein type 11 subunit alpha
Gene Name SCN11A
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.1187
Sodium channel protein type 10 subunit alpha
Name Sodium channel protein type 10 subunit alpha
Gene Name SCN10A
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7023
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action unknown
Actions antagonist
References
  • Carrera MR, Meijler MM, Janda KD: Cocaine pharmacology and current pharmacotherapies for its abuse. Bioorg Med Chem. 2004 Oct 1;12(19):5019-30. - Pubmed
DTHybrid score 0.6258
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action unknown
Actions antagonist
References
  • Carrera MR, Meijler MM, Janda KD: Cocaine pharmacology and current pharmacotherapies for its abuse. Bioorg Med Chem. 2004 Oct 1;12(19):5019-30. - Pubmed
  • Sharkey J, Ritz MC, Schenden JA, Hanson RC, Kuhar MJ: Cocaine inhibits muscarinic cholinergic receptors in heart and brain. J Pharmacol Exp Ther. 1988 Sep;246(3):1048-52. - Pubmed
DTHybrid score 0.477

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Ladona MG, Gonzalez ML, Rane A, Peter RM, de la Torre R: Cocaine metabolism in human fetal and adult liver microsomes is related to cytochrome P450 3A expression. Life Sci. 2000 Dec 15;68(4):431-43. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8759
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.4696
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.3759
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.793
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5462
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4068

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Grundemann D, Koster S, Kiefer N, Breidert T, Engelhardt M, Spitzenberger F, Obermuller N, Schomig E: Transport of monoamine transmitters by the organic cation transporter type 2, OCT2. J Biol Chem. 1998 Nov 20;273(47):30915-20. - Pubmed
DTHybrid score 0.2328

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.4179
1588 Multidrug resistance protein 1 ABCB1 0.3817
4200 Cytochrome P450 1A2 CYP1A2 0.3671
51 Muscarinic acetylcholine receptor M3 CHRM3 0.3141
6030 Cytochrome P450 2B6 CYP2B6 0.2553
492 Histamine H1 receptor HRH1 0.2021
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1872
6013 Cytochrome P450 2E1 CYP2E1 0.1783
556 Alpha-1A adrenergic receptor ADRA1A 0.1626
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1587
3923 Cholinesterase BCHE 0.1509
6145 Solute carrier family 22 member 1 SLC22A1 0.1444
502 5-hydroxytryptamine 2A receptor HTR2A 0.1409
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1393
6024 Cytochrome P450 1A1 CYP1A1 0.1276
587 Serum albumin ALB 0.1153
5718 Cytochrome P450 2A6 CYP2A6 0.1152
3941 Amine oxidase [flavin-containing] A MAOA 0.1117
590 5-hydroxytryptamine 2C receptor HTR2C 0.102
318 Alpha-2A adrenergic receptor ADRA2A 0.1004
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0979
831 D(2) dopamine receptor DRD2 0.0978
131 Synaptic vesicular amine transporter SLC18A2 0.0976
632 Alpha-1B adrenergic receptor ADRA1B 0.0963
3939 Amine oxidase [flavin-containing] B MAOB 0.0952
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0945
118 Organic cation/carnitine transporter 2 SLC22A5 0.0894
20 Prostaglandin G/H synthase 1 PTGS1 0.0878
341 5-hydroxytryptamine 3 receptor HTR3A 0.0873
6106 Cytochrome P450 2C18 CYP2C18 0.0839
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0821
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0795
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0789
6147 Solute carrier family 22 member 3 SLC22A3 0.0753
320 5-hydroxytryptamine 1A receptor HTR1A 0.074
766 Beta-2 adrenergic receptor ADRB2 0.0697
23 D(1A) dopamine receptor DRD1 0.0667
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0664
465 Calmodulin CALM1 0.0624
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0618
833 Organic cation/carnitine transporter 1 SLC22A4 0.0616
862 Multidrug resistance-associated protein 1 ABCC1 0.0613
193 Beta-1 adrenergic receptor ADRB1 0.0603
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0597
629 Alpha-2B adrenergic receptor ADRA2B 0.0576
436 5-hydroxytryptamine 2B receptor HTR2B 0.0573
847 Mu-type opioid receptor OPRM1 0.0573
378 Alpha-2C adrenergic receptor ADRA2C 0.0517
1729 Solute carrier family 22 member 6 SLC22A6 0.0506
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.049
789 Alpha-1D adrenergic receptor ADRA1D 0.0486
467 Delta-type opioid receptor OPRD1 0.048
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0475
776 Bile salt export pump ABCB11 0.0462
696 Kappa-type opioid receptor OPRK1 0.0452
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0441
1898 Cytochrome P450 1B1 CYP1B1 0.0434
290 Prostaglandin G/H synthase 2 PTGS2 0.0413
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0409
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0408
6142 Solute carrier family 22 member 8 SLC22A8 0.0408
638 D(3) dopamine receptor DRD3 0.0399
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0392
6031 Cytochrome P450 3A43 CYP3A43 0.0377
3811 Cytochrome P450 19A1 CYP19A1 0.0376
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0376
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0365
1656 CYP2B protein CYP2B 0.0362
1636 Trace amine-associated receptor 1 TAAR1 0.0344
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0337
871 Glucocorticoid receptor NR3C1 0.0337
432 D(4) dopamine receptor DRD4 0.0336
4604 Liver carboxylesterase 1 CES1 0.0334
6143 Solute carrier family 22 member 7 SLC22A7 0.0331
124 Histamine H2 receptor HRH2 0.0329
6182 Cytochrome P450 2J2 CYP2J2 0.0326
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.032
2164 Multidrug resistance-associated protein 4 ABCC4 0.032
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0316
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0305
474 Acetylcholinesterase ACHE 0.0295
731 HIV-1 protease HIV-1 protease 0.0295
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0292
885 5-hydroxytryptamine 1B receptor HTR1B 0.0288
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0288
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0288
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0284
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.028
136 Estrogen receptor ESR1 0.0279
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0278
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0278
6133 Sodium channel subunit beta-2 SCN2B 0.027
6134 Sodium channel subunit beta-3 SCN3B 0.027
6132 Sodium channel subunit beta-1 SCN1B 0.027
6135 Sodium channel subunit beta-4 SCN4B 0.027
6127 Carbonic anhydrase-related protein CA8 0.027
6128 Carbonic anhydrase-related protein 10 CA10 0.027
6129 Carbonic anhydrase-related protein 11 CA11 0.027
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.026
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0254
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0252
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0248
6148 Multidrug resistance-associated protein 7 ABCC10 0.0243
723 Cytosolic phospholipase A2 PLA2G4A 0.0238
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0237
725 5-hydroxytryptamine 1D receptor HTR1D 0.0237
844 Epidermal growth factor receptor EGFR 0.0227
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0223
260 Cytochrome P450 51 ERG11 0.0221
761 Cytochrome P450 51 ERG11 0.0221
3163 Cytochrome P450 51 cyp51 0.0221
163 D(1B) dopamine receptor DRD5 0.022
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0218
1517 Beta-3 adrenergic receptor ADRB3 0.0217
1024 Solute carrier family 22 member 11 SLC22A11 0.0217
6020 Aldehyde oxidase AOX1 0.0217
614 Progesterone receptor PGR 0.0217
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0216
817 DNA topoisomerase 2-alpha TOP2A 0.0215
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0214
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0213
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0213
6130 Carbonic anhydrase 13 CA13 0.021
94 5-hydroxytryptamine 4 receptor HTR4 0.0208
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0205
295 Carbonic anhydrase 1 CA1 0.0203
6131 Carbonic anhydrase 14 CA14 0.0202
6126 Carbonic anhydrase 7 CA7 0.0201
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0201
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0201
1757 Myeloperoxidase MPO 0.02
6432 Transporter snf 0.0198
592 Carbonic anhydrase 4 CA4 0.0196
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0194
6122 Carbonic anhydrase 3 CA3 0.0192
737 Mineralocorticoid receptor NR3C2 0.0192
468 Cytochrome P450 4A11 CYP4A11 0.0191
6220 Aryl hydrocarbon receptor AHR 0.0189
172 Potassium channel subfamily K member 1 KCNK1 0.0187
380 Cytochrome P450 17A1 CYP17A1 0.0184
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0183
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0183
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0182
716 5-hydroxytryptamine 7 receptor HTR7 0.018
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0177
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0173
4120 NADPH--cytochrome P450 reductase POR 0.0173
811 Translocator protein TSPO 0.0171
1256 5-hydroxytryptamine 6 receptor HTR6 0.0171
891 Dihydropteroate synthase folP 0.0171
5359 Dihydropteroate synthase folP 0.0171
7175 Dihydropteroate synthase sulI 0.0171
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.017
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0166
4205 Carbonic anhydrase 9 CA9 0.0166
3007 Carbonic anhydrase 12 CA12 0.0166
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0165
504 Mast/stem cell growth factor receptor KIT 0.0164
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0162
6136 Multidrug resistance-associated protein 5 ABCC5 0.0161
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.016
6137 Multidrug resistance-associated protein 6 ABCC6 0.0159
4148 Serine/threonine-protein kinase mTOR MTOR 0.0159
232 Corticosteroid-binding globulin SERPINA6 0.0156
528 5-hydroxytryptamine 1E receptor HTR1E 0.0155
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0154
122 P2Y purinoceptor 12 P2RY12 0.0154
4203 Histamine N-methyltransferase HNMT 0.0148
146 Androgen receptor AR 0.0148
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0147
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0144
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0144
70 Type-1 angiotensin II receptor AGTR1 0.0141
357 Carbonic anhydrase 2 CA2 0.0141
756 Sex hormone-binding globulin SHBG 0.014
7 Nitric oxide synthase, inducible NOS2 0.0138
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0137
6141 Sodium/bile acid cotransporter SLC10A1 0.0133
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0132
477 DNA topoisomerase 4 subunit A parC 0.013
886 DNA topoisomerase 4 subunit A parC 0.013
6226 DNA topoisomerase 4 subunit A parC 0.013
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.013
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0129
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0128
404 DNA gyrase subunit A gyrA 0.0128
6224 DNA gyrase subunit A gyrA 0.0128
29 Tubulin beta-1 chain TUBB1 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
33 Cystine/glutamate transporter SLC7A11 0.0125
228 Beta platelet-derived growth factor receptor PDGFRB 0.0123
407 Vascular endothelial growth factor receptor 2 KDR 0.0121
161 Tubulin beta chain TUBB 0.0119
312 Tubulin beta chain TUB2 0.0119
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0118
4773 Deoxycytidine kinase DCK 0.0117
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0116
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0116
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0116
921 Glutamate receptor 2 GRIA2 0.0116
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0116
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0116
6102 Arylamine N-acetyltransferase 2 NAT2 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0115
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0114
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0113
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0113
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0113
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0113
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0113
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0113
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0112
952 Dipeptidyl peptidase 4 DPP4 0.0111
1618 High affinity nerve growth factor receptor NTRK1 0.0111
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0111
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0111
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0111
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.011
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0109
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0108
1010 Cytochrome P450 51A1 CYP51A1 0.0107
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0107
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0107
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0106
26 Vascular endothelial growth factor receptor 3 FLT4 0.0106
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0105
427 Substance-P receptor TACR1 0.0105
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0104
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0103
738 Monocarboxylate transporter 1 SLC16A1 0.0102
32 Vascular endothelial growth factor receptor 1 FLT1 0.0101
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0101
3876 Aromatic-L-amino-acid decarboxylase DDC 0.01
153 Dopamine beta-hydroxylase DBH 0.0098
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0097
365 Dihydrofolate reductase DHFR 0.0097
2381 Dihydrofolate reductase DFR1 0.0097
2833 Dihydrofolate reductase Not Available 0.0097
2931 Dihydrofolate reductase folA 0.0097
3544 Dihydrofolate reductase folA 0.0097
3682 Dihydrofolate reductase folA 0.0097
6642 Dihydrofolate reductase folA 0.0097
6756 Dihydrofolate reductase dfrA 0.0097
818 50S ribosomal protein L10 rplJ 0.0095
904 Glutathione S-transferase P GSTP1 0.0095
3810 Catechol O-methyltransferase COMT 0.0095
2129 Sucrase-isomaltase, intestinal SI 0.0094
869 Estrogen receptor beta ESR2 0.0094
777 Tumor necrosis factor TNF 0.0093
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0092
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0092
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0092
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0091
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.009
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0089
828 Phenylalanine-4-hydroxylase PAH 0.0089
3109 Phenylalanine-4-hydroxylase phhA 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0088
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0088
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0088
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0087
1770 Phospholipase C PLCL1 0.0087
2841 Phospholipase C plc 0.0087
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0087
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0087
6010 Thiamine transporter 1 SLC19A2 0.0086
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0086
2112 Toll-like receptor 9 TLR9 0.0086
174 Sigma 1-type opioid receptor SIGMAR1 0.0085
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0085
319 Opioid receptor, sigma 1 OPRS1 0.0084
1360 Sphingomyelin phosphodiesterase SMPD1 0.0084
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0084
482 Glycine receptor subunit alpha-1 GLRA1 0.0084
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0083
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0083
768 FK506-binding protein 1A FKBP1A 0.0083
1050 Bile salt sulfotransferase SULT2A1 0.0082
527 Prostacyclin receptor PTGIR 0.0082
6014 Cytochrome P450 2A13 CYP2A13 0.0081
164 Histamine H4 receptor HRH4 0.008
1629 Transcription factor AP-1 JUN 0.008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.008
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.008
6085 Fatty acid-binding protein, intestinal FABP2 0.0079
705 Glutamate receptor 1 GRIA1 0.0078
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0078
3947 Xanthine dehydrogenase/oxidase XDH 0.0077
814 Ryanodine receptor 1 RYR1 0.0077
175 Thiamin pyrophosphokinase 1 TPK1 0.0077
165 FL cytokine receptor FLT3 0.0077
976 Platelet glycoprotein IX GP9 0.0076
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0076
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0075
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0075
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0074
1541 Metalloproteinase mmp20 0.0074
2539 Tubulin alpha-1 chain TUBA4A 0.0073
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0073
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
469 Annexin A1 ANXA1 0.0071
1178 Adenosine A2a receptor ADORA2A 0.0071
88 Retinoic acid receptor RXR-beta RXRB 0.007
751 Potassium channel subfamily K member 6 KCNK6 0.007
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.007
49 Endothelin B receptor EDNRB 0.0069
275 Arachidonate 5-lipoxygenase ALOX5 0.0068
4237 50S ribosomal protein L22 rplV 0.0068
3086 Plasmepsin-2 Not Available 0.0068
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0068
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0067
1196 Complement decay-accelerating factor CD55 0.0067
2981 Phospholipase A2, membrane associated PLA2G2A 0.0066
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0066
1852 Microtubule-associated protein 2 MAP2 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0065
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0065
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0064
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0063
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0063
16 Adenosine A1 receptor ADORA1 0.0063
133 Dihydropterate synthase sulI 0.0063
273 Apoptosis regulator Bcl-2 BCL2 0.0063
54 Prothrombin F2 0.0062
84 Nuclear receptor 0B1 NR0B1 0.0062
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
4122 Histone deacetylase 2 HDAC2 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0061
6146 High affinity copper uptake protein 1 SLC31A1 0.006
373 Transthyretin TTR 0.006
5923 Microtubule-associated protein tau MAPT 0.006
5924 Microtubule-associated protein 4 MAP4 0.006
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
5300 Antigen peptide transporter 1 TAP1 0.0059
1483 Membrane copper amine oxidase AOC3 0.0059
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0058
2808 Chloramphenicol acetyltransferase 3 cat3 0.0058
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0058
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0056
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0055
3611 Cytidine deaminase cdd 0.0055
3707 Cytidine deaminase cdd 0.0055
4211 Cytidine deaminase CDA 0.0055
24 Thymidylate synthase TMP1 0.0055
359 Thymidylate synthase TYMS 0.0055
2626 Thymidylate synthase thyA 0.0055
2729 Thymidylate synthase thyA 0.0055
5352 Thymidylate synthase THYA 0.0055
1341 Histamine H3 receptor HRH3 0.0055
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0055
239 Coagulation factor X F10 0.0055
6506 Stathmin-4 STMN4 0.0055
3932 Glutathione S-transferase A2 GSTA2 0.0054
780 Retinoic acid receptor RXR-gamma RXRG 0.0054
823 Fibroblast growth factor receptor 2 FGFR2 0.0054
4238 50S ribosomal protein L4 rplD 0.0054
5578 50S ribosomal protein L4 rplD 0.0054
6173 50S ribosomal protein L4 rplD 0.0054
6219 50S ribosomal protein L4 rplD 0.0054
856 Vitamin D3 receptor VDR 0.0054
3601 Dihydropteroate synthase 1 folP1 0.0053
3807 Dihydropteroate synthase 1 folP1 0.0053
3808 Dihydropteroate synthase 2 folP2 0.0053
2417 Chloramphenicol acetyltransferase cat 0.0053
3278 Chloramphenicol acetyltransferase cat 0.0053
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0053
2810 Dr hemagglutinin structural subunit draA 0.0052
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
1630 Integrin beta-2 ITGB2 0.0051
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
1275 Estrogen sulfotransferase SULT1E1 0.005
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.005
284 DNA-directed RNA polymerase beta chain rpoB 0.0049
5773 DNA-directed RNA polymerase beta chain rpoB 0.0049
908 Glutathione S-transferase theta-1 GSTT1 0.0049
2449 Tubulin alpha-3 chain TUBA1A 0.0049
4311 tRNA TRDMT1 0.0049
4325 tRNA trmD 0.0049
4328 tRNA trmD 0.0049
173 Toll-like receptor 7 TLR7 0.0049
1830 5'-nucleotidase NT5E 0.0049
1864 RET proto-oncogene RET 0.0048
1192 Sulfotransferase 1A1 SULT1A1 0.0048
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0048
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0048
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0048
6070 Nischarin NISCH 0.0048
6174 50S ribosomal protein L32 rpmF 0.0048
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0047
694 Matrix protein 2 M 0.0047
125 DNA polymerase beta POLB 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
1648 Elastin ELN 0.0046
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0046
3856 Fibroblast growth factor receptor 3 FGFR3 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
4192 DNA topoisomerase 2-beta TOP2B 0.0046
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0045
162 Retinoic acid receptor gamma-1 RARG 0.0045
518 Peroxidase/catalase T katG 0.0045
4217 Telomerase reverse transcriptase TERT 0.0044
6048 Troponin C, skeletal muscle TNNC2 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6211 Tubulin epsilon chain TUBE1 0.0044
6212 Tubulin gamma-1 chain TUBG1 0.0044
6210 Tubulin delta chain TUBD1 0.0044
3809 Estrogen-related receptor gamma ESRRG 0.0043
2472 Voltage-gated potassium channel kcsA 0.0043
6366 Voltage-gated potassium channel kcsA 0.0043
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0043
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
3913 Glutamic acid decarboxylase GAD65 0.0042
6044 Serum paraoxonase/lactonase 3 PON3 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0041
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0041
581 Cytochrome P450 2R1 CYP2R1 0.0041
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
6138 Multidrug resistance protein 3 ABCB4 0.0039
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0039
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0039
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0039
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0039
572 Integrin alpha-L ITGAL 0.0038
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
5787 Angiopoietin-1 receptor TEK 0.0038
183 Vascular endothelial growth factor A VEGFA 0.0038
719 Retinoic acid receptor responder protein 1 RARRES1 0.0038
770 Retinoic acid-induced protein 3 GPRC5A 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
6163 Copper-transporting ATPase 2 ATP7B 0.0037
6165 Copper-transporting ATPase 1 ATP7A 0.0037
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
896 Glutathione S-transferase Mu 1 GSTM1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0036
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0036
672 Prostaglandin F2-alpha receptor PTGFR 0.0035
3904 Alanine aminotransferase 2 GPT2 0.0035
735 Alanine aminotransferase 1 GPT 0.0035
5126 Arginase rocF 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6149 Solute carrier family 22 member 10 SLC22A10 0.0034
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0034
2320 Thymidine kinase, cytosolic TK1 0.0034
5934 Cytochrome P450 26A1 CYP26A1 0.0034
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0033
569 Retinal dehydrogenase 2 ALDH1A2 0.0033
267 Plasminogen activator inhibitor 1 SERPINE1 0.0033
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0033
5880 Thrombopoietin receptor MPL 0.0033
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0031
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0031
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0031
6111 DNA polymerase epsilon subunit 4 POLE4 0.0031
6112 DNA polymerase epsilon subunit 3 POLE3 0.0031
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0031
6110 DNA polymerase epsilon subunit 2 POLE2 0.0031
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0031
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0031
740 Argininosuccinate synthase ASS1 0.0031
865 Argininosuccinate synthase ASS1 0.0031
2680 Argininosuccinate synthase argG 0.0031
3194 Argininosuccinate synthase argG 0.0031
611 Retinal dehydrogenase 1 ALDH1A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6218 Pannexin-1 PANX1 0.003
2300 Lysozyme E 0.003
3633 Lysozyme R 0.003
5597 Lysozyme 17 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.003
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.003
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.003
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
2216 Fibroblast growth factor receptor 4 FGFR4 0.0029
1992 Vitamin D-binding protein GC 0.0029
6824 Tyrosine-protein kinase Lyn LYN 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0029
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6151 Monocarboxylate transporter 10 SLC16A10 0.0028
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
624 Guanidinoacetate N-methyltransferase GAMT 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4103 Proteasome subunit beta type 2 PSMB2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0027
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
537 ATP synthase delta chain, mitochondrial ATP5D 0.0027
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0026
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0026
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0026
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0025
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
563 Thyroid peroxidase TPO 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0025
489 Monocarboxylate transporter 2 SLC16A7 0.0025
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
342 P protein [Includes: DNA-directed DNA polymerase P 0.0024
612 P protein [Includes: DNA-directed DNA polymerase P 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
229 Retinoic acid receptor beta RARB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0024
936 Ephrin type-A receptor 2 EPHA2 0.0024
603 DNA polymerase alpha catalytic subunit POLA1 0.0024
730 Retinoic acid receptor alpha RARA 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
3404 Exotoxin A eta 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6171 Solute carrier family 28 member 3 SLC28A3 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
5626 Nucleoside diphosphate kinase B NME2 0.0021
3937 Fatty-acid amide hydrolase FAAH 0.002
594 Thyroxine-binding globulin SERPINA7 0.002
702 UMP-CMP kinase CMPK1 0.002
1039 Histone deacetylase 9 HDAC9 0.002
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.002
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0019
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0019
3926 Choline transporter-like protein 2 SLC44A2 0.0019
3925 Choline transporter-like protein 4 SLC44A4 0.0019
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0019
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0019
3927 Choline transporter-like protein 3 SLC44A3 0.0019
1686 Choline transporter-like protein 1 SLC44A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
861 Choline kinase alpha CHKA 0.0019
769 High-affinity choline transporter 1 SLC5A7 0.0019
700 Choline dehydrogenase, mitochondrial CHDH 0.0019
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0019
576 Choline O-acetyltransferase CHAT 0.0019
3922 Phospholipase D2 PLD2 0.0019
3924 Phospholipase D1 PLD1 0.0019
5682 Ribonuclease pancreatic RNASE1 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
1074 Urokinase-type plasminogen activator PLAU 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
683 Potassium transporter GK0582 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
277 Purine nucleoside phosphorylase PNP 0.0018
2870 Purine nucleoside phosphorylase punA 0.0018
2945 Purine nucleoside phosphorylase punA 0.0018
4659 Purine nucleoside phosphorylase TM_1596 0.0018
4825 Purine nucleoside phosphorylase TTHA1435 0.0018
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0018
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
106 Cannabinoid receptor 2 CNR2 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
5294 Nucleoside diphosphate kinase A NME1 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
5798 Mitogen-activated protein kinase 11 MAPK11 0.0016
2207 Rhodopsin RHO 0.0016
3233 Bile acid receptor NR1H4 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
3957 Adenosine deaminase ADA 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
2021 Thrombomodulin THBD 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
605 Fumarate reductase flavoprotein subunit frdA 0.0012
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0012
3673 Fumarate reductase flavoprotein subunit fccA 0.0012
4912 Fumarate reductase flavoprotein subunit ifcA 0.0012
6549 Fumarate reductase flavoprotein subunit frdA 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
291 Nitric-oxide synthase, endothelial NOS3 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.001
3917 Methylenetetrahydrofolate reductase MTHFR 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6677 Myelin P2 protein PMP2 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
2298 Cytochrome P450-cam camC 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
3221 Cytochrome c4 cc4 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
1507 Cytochrome c CYCS 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
2240 Cell division protein kinase 2 CDK2 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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