DT-Web

DB00347 - Trimethadione


Identification
Name Trimethadione
Accession Number DB00347 (APRD00315)
Type small molecule
Description An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 143.1406
Groups approved
Monoisotopic Weight 143.058243159
Pharmacology
Indication Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.
Mechanism of action Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
Absorption Not Available
Protein binding 90%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Symptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Disulfiram Disulfiram, a strong CYP2E1 inhibitor, may decrease the metabolism and clearance of Trimethadione, a CYP2E1 substrate. Consider alternate therapy or monitor for changes in Trimethadione therapeutic and adverse effects if Disulfiram is initiated, discontinued or dose changed.
Triprolidine The CNS depressants, Triprolidine and Trimethadione, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Food Interactions Not Available

Targets


Voltage-dependent T-type calcium channel subunit alpha-1G
Name Voltage-dependent T-type calcium channel subunit alpha-1G
Gene Name CACNA1G
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Shen H, Zhang B, Shin JH, Lei D, Du Y, Gao X, Wang Q, Ohlemiller KK, Piccirillo J, Bao J: Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss. Hear Res. 2007 Apr;226(1-2):52-60. Epub 2006 Dec 31. - Pubmed
  • Barton ME, Eberle EL, Shannon HE: The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil. Eur J Pharmacol. 2005 Oct 3;521(1-3):79-85. Epub 2005 Sep 19. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.2239

Enzymes


Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Tanaka E, Kurata N, Yasuhara H: Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes. J Clin Pharm Ther. 2003 Dec;28(6):493-6. - Pubmed
  • Kurata N, Nishimura Y, Iwase M, Fischer NE, Tang BK, Inaba T, Yasuhara H: Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica. 1998 Nov;28(11):1041-7. - Pubmed
DTHybrid score 0.2927
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Tanaka E, Kurata N, Yasuhara H: Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes. J Clin Pharm Ther. 2003 Dec;28(6):493-6. - Pubmed
  • Kurata N, Nishimura Y, Iwase M, Fischer NE, Tang BK, Inaba T, Yasuhara H: Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica. 1998 Nov;28(11):1041-7. - Pubmed
DTHybrid score 0.5355
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Kurata N, Nishimura Y, Iwase M, Fischer NE, Tang BK, Inaba T, Yasuhara H: Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica. 1998 Nov;28(11):1041-7. - Pubmed
DTHybrid score 0.3207
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Tanaka E, Kurata N, Yasuhara H: Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes. J Clin Pharm Ther. 2003 Dec;28(6):493-6. - Pubmed
  • Kurata N, Nishimura Y, Iwase M, Fischer NE, Tang BK, Inaba T, Yasuhara H: Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica. 1998 Nov;28(11):1041-7. - Pubmed
DTHybrid score 0.4607
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Kurata N, Nishimura Y, Iwase M, Fischer NE, Tang BK, Inaba T, Yasuhara H: Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica. 1998 Nov;28(11):1041-7. - Pubmed
DTHybrid score 0.4177

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2579
4200 Cytochrome P450 1A2 CYP1A2 0.2251
1588 Multidrug resistance protein 1 ABCB1 0.1757
4118 Cytochrome P450 3A5 CYP3A5 0.1738
6030 Cytochrome P450 2B6 CYP2B6 0.1616
6107 Cytochrome P450 3A7 CYP3A7 0.1298
5718 Cytochrome P450 2A6 CYP2A6 0.1095
6024 Cytochrome P450 1A1 CYP1A1 0.1037
20 Prostaglandin G/H synthase 1 PTGS1 0.0899
587 Serum albumin ALB 0.078
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0647
492 Histamine H1 receptor HRH1 0.0576
6106 Cytochrome P450 2C18 CYP2C18 0.0566
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0538
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0483
290 Prostaglandin G/H synthase 2 PTGS2 0.0482
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0445
3811 Cytochrome P450 19A1 CYP19A1 0.042
6031 Cytochrome P450 3A43 CYP3A43 0.0415
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.041
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0407
824 Sodium-dependent serotonin transporter SLC6A4 0.04
1729 Solute carrier family 22 member 6 SLC22A6 0.0399
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0382
862 Multidrug resistance-associated protein 1 ABCC1 0.037
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0355
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.035
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0343
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0335
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0327
1898 Cytochrome P450 1B1 CYP1B1 0.0315
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0315
260 Cytochrome P450 51 ERG11 0.0309
761 Cytochrome P450 51 ERG11 0.0309
3163 Cytochrome P450 51 cyp51 0.0309
831 D(2) dopamine receptor DRD2 0.0303
540 Sodium-dependent noradrenaline transporter SLC6A2 0.03
136 Estrogen receptor ESR1 0.0288
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0285
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0283
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0282
502 5-hydroxytryptamine 2A receptor HTR2A 0.0279
776 Bile salt export pump ABCB11 0.0279
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0273
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0272
6145 Solute carrier family 22 member 1 SLC22A1 0.027
2164 Multidrug resistance-associated protein 4 ABCC4 0.027
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0261
465 Calmodulin CALM1 0.0259
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0259
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0255
556 Alpha-1A adrenergic receptor ADRA1A 0.0246
731 HIV-1 protease HIV-1 protease 0.0241
6144 Solute carrier family 22 member 2 SLC22A2 0.024
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0237
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0237
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0232
871 Glucocorticoid receptor NR3C1 0.0232
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0231
3941 Amine oxidase [flavin-containing] A MAOA 0.023
6142 Solute carrier family 22 member 8 SLC22A8 0.0225
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0219
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0215
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0211
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0206
468 Cytochrome P450 4A11 CYP4A11 0.02
341 5-hydroxytryptamine 3 receptor HTR3A 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
6143 Solute carrier family 22 member 7 SLC22A7 0.0188
891 Dihydropteroate synthase folP 0.0188
5359 Dihydropteroate synthase folP 0.0188
7175 Dihydropteroate synthase sulI 0.0188
3939 Amine oxidase [flavin-containing] B MAOB 0.0188
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0187
122 P2Y purinoceptor 12 P2RY12 0.0187
23 D(1A) dopamine receptor DRD1 0.0186
847 Mu-type opioid receptor OPRM1 0.0185
713 Sodium-dependent dopamine transporter SLC6A3 0.0185
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0184
590 5-hydroxytryptamine 2C receptor HTR2C 0.0183
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0182
318 Alpha-2A adrenergic receptor ADRA2A 0.018
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0179
118 Organic cation/carnitine transporter 2 SLC22A5 0.0177
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0176
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0173
632 Alpha-1B adrenergic receptor ADRA1B 0.0172
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0172
467 Delta-type opioid receptor OPRD1 0.0171
320 5-hydroxytryptamine 1A receptor HTR1A 0.0171
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0169
766 Beta-2 adrenergic receptor ADRB2 0.0165
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0163
696 Kappa-type opioid receptor OPRK1 0.0162
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0154
146 Androgen receptor AR 0.0152
80 Peroxisome proliferator-activated receptor alpha PPARA 0.015
70 Type-1 angiotensin II receptor AGTR1 0.0148
811 Translocator protein TSPO 0.0146
1024 Solute carrier family 22 member 11 SLC22A11 0.0146
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0145
592 Carbonic anhydrase 4 CA4 0.0145
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0144
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0144
6102 Arylamine N-acetyltransferase 2 NAT2 0.0143
833 Organic cation/carnitine transporter 1 SLC22A4 0.0141
6182 Cytochrome P450 2J2 CYP2J2 0.0138
6147 Solute carrier family 22 member 3 SLC22A3 0.0137
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0134
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0132
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0132
4116 Dihydropteroate synthetase Not Available 0.0131
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.013
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.013
295 Carbonic anhydrase 1 CA1 0.013
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.013
789 Alpha-1D adrenergic receptor ADRA1D 0.0127
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0126
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0125
6148 Multidrug resistance-associated protein 7 ABCC10 0.0124
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0124
777 Tumor necrosis factor TNF 0.0123
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0122
817 DNA topoisomerase 2-alpha TOP2A 0.012
6126 Carbonic anhydrase 7 CA7 0.012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0119
885 5-hydroxytryptamine 1B receptor HTR1B 0.0118
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0117
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0117
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0117
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0114
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0113
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0113
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0113
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0113
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0112
638 D(3) dopamine receptor DRD3 0.0111
614 Progesterone receptor PGR 0.011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.011
6141 Sodium/bile acid cotransporter SLC10A1 0.0109
357 Carbonic anhydrase 2 CA2 0.0109
6136 Multidrug resistance-associated protein 5 ABCC5 0.0109
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0108
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0108
482 Glycine receptor subunit alpha-1 GLRA1 0.0108
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0107
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0107
4604 Liver carboxylesterase 1 CES1 0.0107
16 Adenosine A1 receptor ADORA1 0.0106
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0105
1010 Cytochrome P450 51A1 CYP51A1 0.0102
365 Dihydrofolate reductase DHFR 0.0102
2381 Dihydrofolate reductase DFR1 0.0102
2833 Dihydrofolate reductase Not Available 0.0102
2931 Dihydrofolate reductase folA 0.0102
3544 Dihydrofolate reductase folA 0.0102
3682 Dihydrofolate reductase folA 0.0102
6642 Dihydrofolate reductase folA 0.0102
6756 Dihydrofolate reductase dfrA 0.0102
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0102
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.01
193 Beta-1 adrenergic receptor ADRB1 0.0099
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0097
1757 Myeloperoxidase MPO 0.0096
725 5-hydroxytryptamine 1D receptor HTR1D 0.0096
29 Tubulin beta-1 chain TUBB1 0.0096
49 Endothelin B receptor EDNRB 0.0096
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0095
6020 Aldehyde oxidase AOX1 0.0094
6137 Multidrug resistance-associated protein 6 ABCC6 0.0094
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0094
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0093
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0093
94 5-hydroxytryptamine 4 receptor HTR4 0.0092
6220 Aryl hydrocarbon receptor AHR 0.0092
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0092
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0091
844 Epidermal growth factor receptor EGFR 0.0091
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0091
3810 Catechol O-methyltransferase COMT 0.0091
578 Endothelin-1 receptor EDNRA 0.009
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0089
380 Cytochrome P450 17A1 CYP17A1 0.0089
3923 Cholinesterase BCHE 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
869 Estrogen receptor beta ESR2 0.0088
6014 Cytochrome P450 2A13 CYP2A13 0.0088
504 Mast/stem cell growth factor receptor KIT 0.0087
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0086
161 Tubulin beta chain TUBB 0.0086
312 Tubulin beta chain TUB2 0.0086
705 Glutamate receptor 1 GRIA1 0.0086
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0085
629 Alpha-2B adrenergic receptor ADRA2B 0.0084
407 Vascular endothelial growth factor receptor 2 KDR 0.0084
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0083
1178 Adenosine A2a receptor ADORA2A 0.0083
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0083
921 Glutamate receptor 2 GRIA2 0.0083
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0082
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0081
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
373 Transthyretin TTR 0.008
436 5-hydroxytryptamine 2B receptor HTR2B 0.008
124 Histamine H2 receptor HRH2 0.008
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0078
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0078
6131 Carbonic anhydrase 14 CA14 0.0078
537 ATP synthase delta chain, mitochondrial ATP5D 0.0077
756 Sex hormone-binding globulin SHBG 0.0077
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0077
432 D(4) dopamine receptor DRD4 0.0076
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0076
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0076
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0076
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0076
4122 Histone deacetylase 2 HDAC2 0.0075
378 Alpha-2C adrenergic receptor ADRA2C 0.0075
1541 Metalloproteinase mmp20 0.0074
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0074
427 Substance-P receptor TACR1 0.0074
4120 NADPH--cytochrome P450 reductase POR 0.0073
6122 Carbonic anhydrase 3 CA3 0.0073
6133 Sodium channel subunit beta-2 SCN2B 0.0073
6135 Sodium channel subunit beta-4 SCN4B 0.0073
6134 Sodium channel subunit beta-3 SCN3B 0.0073
6132 Sodium channel subunit beta-1 SCN1B 0.0073
6127 Carbonic anhydrase-related protein CA8 0.0073
6129 Carbonic anhydrase-related protein 11 CA11 0.0073
6128 Carbonic anhydrase-related protein 10 CA10 0.0073
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0073
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
818 50S ribosomal protein L10 rplJ 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
952 Dipeptidyl peptidase 4 DPP4 0.007
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0068
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0068
518 Peroxidase/catalase T katG 0.0068
26 Vascular endothelial growth factor receptor 3 FLT4 0.0068
716 5-hydroxytryptamine 7 receptor HTR7 0.0067
6085 Fatty acid-binding protein, intestinal FABP2 0.0067
275 Arachidonate 5-lipoxygenase ALOX5 0.0067
183 Vascular endothelial growth factor A VEGFA 0.0066
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0066
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
6130 Carbonic anhydrase 13 CA13 0.0065
32 Vascular endothelial growth factor receptor 1 FLT1 0.0065
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0064
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0064
153 Dopamine beta-hydroxylase DBH 0.0063
133 Dihydropterate synthase sulI 0.0063
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0062
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0062
823 Fibroblast growth factor receptor 2 FGFR2 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0062
814 Ryanodine receptor 1 RYR1 0.0061
3947 Xanthine dehydrogenase/oxidase XDH 0.006
3007 Carbonic anhydrase 12 CA12 0.006
4205 Carbonic anhydrase 9 CA9 0.006
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
737 Mineralocorticoid receptor NR3C2 0.0059
444 Alcohol dehydrogenase 1B ADH1B 0.0059
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0058
228 Beta platelet-derived growth factor receptor PDGFRB 0.0058
251 Alcohol dehydrogenase 1A ADH1A 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
6138 Multidrug resistance protein 3 ABCB4 0.0058
88 Retinoic acid receptor RXR-beta RXRB 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0056
856 Vitamin D3 receptor VDR 0.0055
24 Thymidylate synthase TMP1 0.0055
359 Thymidylate synthase TYMS 0.0055
2626 Thymidylate synthase thyA 0.0055
2729 Thymidylate synthase thyA 0.0055
5352 Thymidylate synthase THYA 0.0055
1656 CYP2B protein CYP2B 0.0055
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0055
5300 Antigen peptide transporter 1 TAP1 0.0055
1275 Estrogen sulfotransferase SULT1E1 0.0054
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0054
558 Solute carrier family 12 member 1 SLC12A1 0.0054
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0053
1050 Bile salt sulfotransferase SULT2A1 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
3932 Glutathione S-transferase A2 GSTA2 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
3808 Dihydropteroate synthase 2 folP2 0.0051
3601 Dihydropteroate synthase 1 folP1 0.0051
3807 Dihydropteroate synthase 1 folP1 0.0051
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.005
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.005
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0049
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0049
634 Squalene monooxygenase SQLE 0.0049
7196 Squalene monooxygenase ERG1 0.0049
1192 Sulfotransferase 1A1 SULT1A1 0.0049
3809 Estrogen-related receptor gamma ESRRG 0.0048
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0048
284 DNA-directed RNA polymerase beta chain rpoB 0.0048
5773 DNA-directed RNA polymerase beta chain rpoB 0.0048
738 Monocarboxylate transporter 1 SLC16A1 0.0048
1618 High affinity nerve growth factor receptor NTRK1 0.0047
563 Thyroid peroxidase TPO 0.0047
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
1253 Interferon gamma IFNG 0.0046
1648 Elastin ELN 0.0046
2230 Catalase CAT 0.0046
3249 Catalase katA 0.0046
3625 Catalase katA 0.0046
4539 Catalase katA 0.0046
4941 Catalase katB 0.0046
528 5-hydroxytryptamine 1E receptor HTR1E 0.0046
1256 5-hydroxytryptamine 6 receptor HTR6 0.0046
904 Glutathione S-transferase P GSTP1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
474 Acetylcholinesterase ACHE 0.0045
517 Alcohol dehydrogenase 1C ADH1C 0.0045
6174 50S ribosomal protein L32 rpmF 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
319 Opioid receptor, sigma 1 OPRS1 0.0044
1196 Complement decay-accelerating factor CD55 0.0044
4311 tRNA TRDMT1 0.0044
4325 tRNA trmD 0.0044
4328 tRNA trmD 0.0044
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0044
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0044
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0044
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0044
130 Prostacyclin synthase PTGIS 0.0044
581 Cytochrome P450 2R1 CYP2R1 0.0043
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0042
3937 Fatty-acid amide hydrolase FAAH 0.0042
976 Platelet glycoprotein IX GP9 0.0042
163 D(1B) dopamine receptor DRD5 0.0042
54 Prothrombin F2 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
239 Coagulation factor X F10 0.004
1629 Transcription factor AP-1 JUN 0.004
3913 Glutamic acid decarboxylase GAD65 0.004
6146 High affinity copper uptake protein 1 SLC31A1 0.004
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.004
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.004
780 Retinoic acid receptor RXR-gamma RXRG 0.0039
84 Nuclear receptor 0B1 NR0B1 0.0039
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0039
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2808 Chloramphenicol acetyltransferase 3 cat3 0.0038
469 Annexin A1 ANXA1 0.0038
6043 Putative G-protein coupled receptor 44 GPR44 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0038
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0038
85 Growth hormone receptor GHR 0.0038
174 Sigma 1-type opioid receptor SIGMAR1 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0037
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0037
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0037
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
6432 Transporter snf 0.0036
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
3404 Exotoxin A eta 0.0036
65 Matrix metalloproteinase-9 Not Available 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2417 Chloramphenicol acetyltransferase cat 0.0035
3278 Chloramphenicol acetyltransferase cat 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0034
2981 Phospholipase A2, membrane associated PLA2G2A 0.0034
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0034
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
735 Alanine aminotransferase 1 GPT 0.0033
3904 Alanine aminotransferase 2 GPT2 0.0033
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0033
5880 Thrombopoietin receptor MPL 0.0033
162 Retinoic acid receptor gamma-1 RARG 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0032
5787 Angiopoietin-1 receptor TEK 0.0032
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1992 Vitamin D-binding protein GC 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
273 Apoptosis regulator Bcl-2 BCL2 0.0031
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
164 Histamine H4 receptor HRH4 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
106 Cannabinoid receptor 2 CNR2 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
165 FL cytokine receptor FLT3 0.003
3917 Methylenetetrahydrofolate reductase MTHFR 0.003
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.003
908 Glutathione S-transferase theta-1 GSTT1 0.003
1630 Integrin beta-2 ITGB2 0.0029
4103 Proteasome subunit beta type 2 PSMB2 0.0029
4102 Proteasome subunit beta type 5 PSMB5 0.0029
4101 Proteasome subunit beta type 1 PSMB1 0.0029
7 Nitric oxide synthase, inducible NOS2 0.0029
2298 Cytochrome P450-cam camC 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
268 Adenosine A2b receptor ADORA2B 0.0028
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0028
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
4217 Telomerase reverse transcriptase TERT 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0027
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0027
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0027
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6149 Solute carrier family 22 member 10 SLC22A10 0.0026
3856 Fibroblast growth factor receptor 3 FGFR3 0.0026
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0026
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
358 Cystathionine beta-synthase CBS 0.0025
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0025
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6044 Serum paraoxonase/lactonase 3 PON3 0.0024
2112 Toll-like receptor 9 TLR9 0.0024
229 Retinoic acid receptor beta RARB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1374 Natriuretic peptides B NPPB 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
730 Retinoic acid receptor alpha RARA 0.0023
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0022
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0022
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0022
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0022
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0022
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0022
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
572 Integrin alpha-L ITGAL 0.0022
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0022
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0022
751 Potassium channel subfamily K member 6 KCNK6 0.0022
5798 Mitogen-activated protein kinase 11 MAPK11 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
267 Plasminogen activator inhibitor 1 SERPINE1 0.0022
2232 Interleukin-5 IL5 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
4192 DNA topoisomerase 2-beta TOP2B 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
936 Ephrin type-A receptor 2 EPHA2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.002
172 Potassium channel subfamily K member 1 KCNK1 0.002
2021 Thrombomodulin THBD 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
6218 Pannexin-1 PANX1 0.0019
6221 Steroid hormone receptor ERR1 ESRRA 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
5934 Cytochrome P450 26A1 CYP26A1 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
1039 Histone deacetylase 9 HDAC9 0.0019
2207 Rhodopsin RHO 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
3957 Adenosine deaminase ADA 0.0019
896 Glutathione S-transferase Mu 1 GSTM1 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
511 5-hydroxytryptamine 1F receptor HTR1F 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
1262 Corticotropin-lipotropin POMC 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
489 Monocarboxylate transporter 2 SLC16A7 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
683 Potassium transporter GK0582 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6459 Glycodelin PAEP 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0017
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0017
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
4773 Deoxycytidine kinase DCK 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
3830 Calreticulin CALR 0.0017
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0017
1268 Neuropeptide S receptor NPSR1 0.0017
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0017
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0016
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0016
3221 Cytochrome c4 cc4 0.0016
1517 Beta-3 adrenergic receptor ADRB3 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
173 Toll-like receptor 7 TLR7 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0016
3233 Bile acid receptor NR1H4 0.0015
33 Cystine/glutamate transporter SLC7A11 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
1341 Histamine H3 receptor HRH3 0.0014
611 Retinal dehydrogenase 1 ALDH1A1 0.0014
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0014
1864 RET proto-oncogene RET 0.0014
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0014
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0014
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
291 Nitric-oxide synthase, endothelial NOS3 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
6163 Copper-transporting ATPase 2 ATP7B 0.0014
6165 Copper-transporting ATPase 1 ATP7A 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0013
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0013
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0012
605 Fumarate reductase flavoprotein subunit frdA 0.0012
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0012
3673 Fumarate reductase flavoprotein subunit fccA 0.0012
4912 Fumarate reductase flavoprotein subunit ifcA 0.0012
6549 Fumarate reductase flavoprotein subunit frdA 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2236 Casein kinase II subunit alpha CSNK2A1 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
760 Fibroblast growth factor 1 FGF1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6677 Myelin P2 protein PMP2 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
798 Osteocalcin BGLAP 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
369 Coagulation factor VII F7 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
2802 Endoglucanase G celCCG 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
1507 Cytochrome c CYCS 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
693 Hemoglobin subunit beta HBB 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
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