DT-Web

DB00238 - Nevirapine


Identification
Name Nevirapine
Accession Number DB00238 (APRD00705, DB08311)
Type small molecule
Description A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. [PubChem] Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 266.2979
Groups approved
Monoisotopic Weight 266.11676109
Pharmacology
Indication For use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.
Mechanism of action Nevirapine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of nevirapine does not compete with template or nucleoside triphosphates.
Absorption Nevirapine is readily absorbed (greater than 90%) after oral administration in healthy subjects and adults with HIV-1 infection. The absolute bioavailability in healthy adults following a single dose administration is 93 ? 9% (mean ? SD) for a 50 mg tablet and 91 ? 8% for an oral solution. Peak plasma nevirapine concentrations of 2 ? 0.4 mcg/mL (7.5 micromolar) were attained by 4 hours following a single 200 mg dose. Nevirapine tablets and suspension have been shown to be comparably bioavailable and interchangeable at doses up to 200 mg. When the oral tablet is given with a high-fat meal, the extent of absorption is compared to that of the fasted-state.
Protein binding 60% bound to plasma protein.
Biotransformation Hepatic. In vivo studies in humans and in vitro studies with human liver microsomes have shown that nevirapine is extensively biotransformed via cytochrome P450 3A4 metabolism to several hydroxylated metabolites.
Route of elimination Thus cytochrome P450 metabolism, glucuronide conjugation, and urinary excretion of glucuronidated metabolites represent the primary route of nevirapine biotransformation and elimination in humans. Only a small fraction (<5%) of the radioactivity in urine (representing <3% of the total dose) was made up of parent compound; therefore, renal excretion plays a minor role in elimination of the parent compound.
Toxicity Symptoms of overdose include edema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonaryinfiltrates, rash, vertigo, vomiting, and weight decrease. The most common adverse reaction is rash.
Affected organisms
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Nevirapine may decrease the anticoagulant effect of acenocoumarol.
Anisindione Nevirapine may decrease the anticoagulant effect of anisindione.
Atazanavir Nevirapine, a strong CYP3A4 inducer, may decrease the serum concentration of atazanavir by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of atazanavir if nevirapine is initiated, discontinued or dose changed.
Atorvastatin Nevirapine, a strong CYP3A4 inducer, may decrease the serum concentration of atorvastatin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of atorvastatin if nevirapine is initiated, discontinued or dose changed.
Dicumarol Nevirapine may decrease the anticoagulant effect of dicumarol.
Estradiol valerate/Dienogest Affects CYP3A4 metabolism, decreases or effects levels of Estradiol valerate/Dienogest.
Etravirine Nevirapine may cause a significant decrease in plasma levels of etravirine and a loss of efficacy. Combination of two NNRTIs has not been demonstrated to be of benefit to HIV therapy.
Ketoconazole Nevirapine, a strong CYP3A4 inducer, may decrease the serum concentration of ketoconazole by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of ketoconazole if nevirapine is initiated, discontinued or dose changed.
Lovastatin The strong CYP3A4 inducer, nevirapine, may decrase the effect of lovastatin by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of lovastatin if nevirapine is initiated, discontinued or dose changed.
Methadone The antiretroviral agent decreases the effect of methadone
Nelfinavir Nevirapine may decrease the effect of nelfinavir.
Quinupristin This combination presents an increased risk of toxicity
Roflumilast Affects CYP3A4 metabolism, decreases level or effect of roflumilast.
Saquinavir Decreases the effect of saquinavir
Simvastatin The strong CYP3A4 inducer, nevirapine, may decrase the effect of simvastatin by increasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of simvastatin if nevirapine is initiated, discontinued or dose changed.
St. John's Wort St. John's Wort decreases nevirapine effect
Telithromycin Nevirapine may decrease the plasma concentration of Telithromycin. Consider alternate therapy.
Temsirolimus Nevirapine may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Tipranavir Nevirapine, a CYP3A4 inducer, may decrease the serum concentration of Tipranavir, a CYP3A4 substrate. Monitor for changesin Tipranavir effect if Nevirapine is initiated, discontinued or dose changed.
Tramadol Nevirapine may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inducer, Nevirapine, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Nevirapine is initiated, discontinued or dose changed.
Vandetanib Decreases levels of vandetanib by affecting CYP3A4 metabolism. Contraindicated.
Warfarin Nevirapine may decrease the anticoagulant effect of warfarin by increasing metabolism of R-warfarin via CYP3A4.
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol.

Targets


Reverse transcriptase
Name Reverse transcriptase
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Ambrose Z, Herman BD, Sheen CW, Zelina S, Moore KL, Tachedjian G, Nissley DV, Sluis-Cremer N: The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs. J Virol. 2009 Apr;83(8):3826-33. Epub 2009 Feb 4. - Pubmed
  • Nikolenko GN, Delviks-Frankenberry KA, Pathak VK: A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors. J Virol. 2010 May;84(10):5238-49. Epub 2010 Mar 10. - Pubmed
  • Ghosn J, Chaix ML, Delaugerre C: HIV-1 resistance to first- and second-generation non-nucleoside reverse transcriptase inhibitors. AIDS Rev. 2009 Jul-Sep;11(3):165-73. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inducer
References
  • Boehringer Ingelheim. Viramune® (nevirapine) tablets and oral suspension prescribing information. Ridgefield, CT; 2008 Jun. -
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3341
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Boehringer Ingelheim. Viramune® (nevirapine) tablets and oral suspension prescribing information. Ridgefield, CT; 2008 Jun. -
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6645
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.318
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4519
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3201
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.495
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4412

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.3181
4924 Cytochrome P450 2C8 CYP2C8 0.2503
1588 Multidrug resistance protein 1 ABCB1 0.2463
6107 Cytochrome P450 3A7 CYP3A7 0.2073
6013 Cytochrome P450 2E1 CYP2E1 0.182
6024 Cytochrome P450 1A1 CYP1A1 0.1456
20 Prostaglandin G/H synthase 1 PTGS1 0.0882
587 Serum albumin ALB 0.0855
492 Histamine H1 receptor HRH1 0.08
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0785
6106 Cytochrome P450 2C18 CYP2C18 0.0665
824 Sodium-dependent serotonin transporter SLC6A4 0.0652
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0544
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0542
502 5-hydroxytryptamine 2A receptor HTR2A 0.0542
3811 Cytochrome P450 19A1 CYP19A1 0.054
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0538
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0523
831 D(2) dopamine receptor DRD2 0.0515
556 Alpha-1A adrenergic receptor ADRA1A 0.0485
862 Multidrug resistance-associated protein 1 ABCC1 0.0475
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0471
6145 Solute carrier family 22 member 1 SLC22A1 0.0447
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0442
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0434
1898 Cytochrome P450 1B1 CYP1B1 0.0426
713 Sodium-dependent dopamine transporter SLC6A3 0.0425
290 Prostaglandin G/H synthase 2 PTGS2 0.042
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0414
1729 Solute carrier family 22 member 6 SLC22A6 0.041
318 Alpha-2A adrenergic receptor ADRA2A 0.0409
766 Beta-2 adrenergic receptor ADRB2 0.0405
6144 Solute carrier family 22 member 2 SLC22A2 0.0394
590 5-hydroxytryptamine 2C receptor HTR2C 0.0393
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0391
847 Mu-type opioid receptor OPRM1 0.0378
118 Organic cation/carnitine transporter 2 SLC22A5 0.0372
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.037
320 5-hydroxytryptamine 1A receptor HTR1A 0.0366
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0366
341 5-hydroxytryptamine 3 receptor HTR3A 0.0358
136 Estrogen receptor ESR1 0.0335
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0334
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0331
776 Bile salt export pump ABCB11 0.0331
617 Muscarinic acetylcholine receptor M2 CHRM2 0.032
23 D(1A) dopamine receptor DRD1 0.0316
3941 Amine oxidase [flavin-containing] A MAOA 0.0313
731 HIV-1 protease HIV-1 protease 0.0306
632 Alpha-1B adrenergic receptor ADRA1B 0.0305
871 Glucocorticoid receptor NR3C1 0.0303
193 Beta-1 adrenergic receptor ADRB1 0.0299
467 Delta-type opioid receptor OPRD1 0.0292
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0282
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0281
468 Cytochrome P450 4A11 CYP4A11 0.0279
6031 Cytochrome P450 3A43 CYP3A43 0.0279
465 Calmodulin CALM1 0.0276
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0276
696 Kappa-type opioid receptor OPRK1 0.0274
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0272
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0263
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0262
817 DNA topoisomerase 2-alpha TOP2A 0.026
36 Insulin receptor INSR 0.0258
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0257
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0256
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0249
638 D(3) dopamine receptor DRD3 0.0248
885 5-hydroxytryptamine 1B receptor HTR1B 0.0245
260 Cytochrome P450 51 ERG11 0.0245
761 Cytochrome P450 51 ERG11 0.0245
3163 Cytochrome P450 51 cyp51 0.0245
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0243
3939 Amine oxidase [flavin-containing] B MAOB 0.0243
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0242
6147 Solute carrier family 22 member 3 SLC22A3 0.0239
6143 Solute carrier family 22 member 7 SLC22A7 0.0236
6142 Solute carrier family 22 member 8 SLC22A8 0.0234
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0232
2164 Multidrug resistance-associated protein 4 ABCC4 0.0232
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0224
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0222
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0218
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0217
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0217
629 Alpha-2B adrenergic receptor ADRA2B 0.0211
6014 Cytochrome P450 2A13 CYP2A13 0.0209
122 P2Y purinoceptor 12 P2RY12 0.0208
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0207
725 5-hydroxytryptamine 1D receptor HTR1D 0.0206
891 Dihydropteroate synthase folP 0.0204
5359 Dihydropteroate synthase folP 0.0204
7175 Dihydropteroate synthase sulI 0.0204
833 Organic cation/carnitine transporter 1 SLC22A4 0.02
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0198
3923 Cholinesterase BCHE 0.0193
477 DNA topoisomerase 4 subunit A parC 0.0189
886 DNA topoisomerase 4 subunit A parC 0.0189
6226 DNA topoisomerase 4 subunit A parC 0.0189
789 Alpha-1D adrenergic receptor ADRA1D 0.0188
378 Alpha-2C adrenergic receptor ADRA2C 0.0188
404 DNA gyrase subunit A gyrA 0.0186
6224 DNA gyrase subunit A gyrA 0.0186
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0183
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0179
6182 Cytochrome P450 2J2 CYP2J2 0.0179
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0179
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0178
432 D(4) dopamine receptor DRD4 0.0174
6220 Aryl hydrocarbon receptor AHR 0.0171
232 Corticosteroid-binding globulin SERPINA6 0.0171
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0168
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0167
705 Glutamate receptor 1 GRIA1 0.0163
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0162
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0162
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0162
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0152
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.015
482 Glycine receptor subunit alpha-1 GLRA1 0.0149
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0148
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0144
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0142
94 5-hydroxytryptamine 4 receptor HTR4 0.0142
614 Progesterone receptor PGR 0.0142
6102 Arylamine N-acetyltransferase 2 NAT2 0.0141
146 Androgen receptor AR 0.0141
504 Mast/stem cell growth factor receptor KIT 0.0141
716 5-hydroxytryptamine 7 receptor HTR7 0.0139
844 Epidermal growth factor receptor EGFR 0.0138
436 5-hydroxytryptamine 2B receptor HTR2B 0.0138
811 Translocator protein TSPO 0.0137
818 50S ribosomal protein L10 rplJ 0.0137
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0137
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0135
6148 Multidrug resistance-associated protein 7 ABCC10 0.0134
6136 Multidrug resistance-associated protein 5 ABCC5 0.0133
4604 Liver carboxylesterase 1 CES1 0.0131
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.013
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0129
1656 CYP2B protein CYP2B 0.0127
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0127
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0126
131 Synaptic vesicular amine transporter SLC18A2 0.0126
537 ATP synthase delta chain, mitochondrial ATP5D 0.0122
777 Tumor necrosis factor TNF 0.0122
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0122
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0122
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.012
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.012
70 Type-1 angiotensin II receptor AGTR1 0.0119
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0119
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0119
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0118
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0117
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0117
6137 Multidrug resistance-associated protein 6 ABCC6 0.0117
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0116
869 Estrogen receptor beta ESR2 0.0116
1010 Cytochrome P450 51A1 CYP51A1 0.0115
4237 50S ribosomal protein L22 rplV 0.0114
407 Vascular endothelial growth factor receptor 2 KDR 0.0114
474 Acetylcholinesterase ACHE 0.0113
380 Cytochrome P450 17A1 CYP17A1 0.0112
163 D(1B) dopamine receptor DRD5 0.0112
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0112
1024 Solute carrier family 22 member 11 SLC22A11 0.0111
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0111
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0111
4148 Serine/threonine-protein kinase mTOR MTOR 0.011
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.011
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.011
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.011
756 Sex hormone-binding globulin SHBG 0.011
4120 NADPH--cytochrome P450 reductase POR 0.0109
174 Sigma 1-type opioid receptor SIGMAR1 0.0109
124 Histamine H2 receptor HRH2 0.0108
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0107
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0107
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0107
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0107
3947 Xanthine dehydrogenase/oxidase XDH 0.0107
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0106
737 Mineralocorticoid receptor NR3C2 0.0106
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0105
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0105
16 Adenosine A1 receptor ADORA1 0.0105
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0104
4238 50S ribosomal protein L4 rplD 0.0104
5578 50S ribosomal protein L4 rplD 0.0104
6173 50S ribosomal protein L4 rplD 0.0104
6219 50S ribosomal protein L4 rplD 0.0104
26 Vascular endothelial growth factor receptor 3 FLT4 0.0103
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0103
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0103
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0102
6020 Aldehyde oxidase AOX1 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
275 Arachidonate 5-lipoxygenase ALOX5 0.0101
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.01
1757 Myeloperoxidase MPO 0.01
1178 Adenosine A2a receptor ADORA2A 0.01
228 Beta platelet-derived growth factor receptor PDGFRB 0.0099
427 Substance-P receptor TACR1 0.0099
32 Vascular endothelial growth factor receptor 1 FLT1 0.0098
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0098
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0096
295 Carbonic anhydrase 1 CA1 0.0096
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
29 Tubulin beta-1 chain TUBB1 0.0094
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0094
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0093
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0093
571 Melatonin receptor type 1A MTNR1A 0.009
362 Melatonin receptor type 1B MTNR1B 0.009
1256 5-hydroxytryptamine 6 receptor HTR6 0.009
3932 Glutathione S-transferase A2 GSTA2 0.009
161 Tubulin beta chain TUBB 0.009
312 Tubulin beta chain TUB2 0.009
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0088
952 Dipeptidyl peptidase 4 DPP4 0.0087
921 Glutamate receptor 2 GRIA2 0.0085
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0085
528 5-hydroxytryptamine 1E receptor HTR1E 0.0085
563 Thyroid peroxidase TPO 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0083
565 Extracellular calcium-sensing receptor CASR 0.008
173 Toll-like receptor 7 TLR7 0.0079
3810 Catechol O-methyltransferase COMT 0.0077
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0076
68 Cannabinoid receptor 1 CNR1 0.0075
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0075
84 Nuclear receptor 0B1 NR0B1 0.0075
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0075
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0075
6141 Sodium/bile acid cotransporter SLC10A1 0.0074
373 Transthyretin TTR 0.0074
284 DNA-directed RNA polymerase beta chain rpoB 0.0073
5773 DNA-directed RNA polymerase beta chain rpoB 0.0073
592 Carbonic anhydrase 4 CA4 0.0073
251 Alcohol dehydrogenase 1A ADH1A 0.0073
54 Prothrombin F2 0.0073
518 Peroxidase/catalase T katG 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
4122 Histone deacetylase 2 HDAC2 0.0072
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0072
365 Dihydrofolate reductase DHFR 0.0072
2381 Dihydrofolate reductase DFR1 0.0072
2833 Dihydrofolate reductase Not Available 0.0072
2931 Dihydrofolate reductase folA 0.0072
3544 Dihydrofolate reductase folA 0.0072
3682 Dihydrofolate reductase folA 0.0072
6642 Dihydrofolate reductase folA 0.0072
6756 Dihydrofolate reductase dfrA 0.0072
1192 Sulfotransferase 1A1 SULT1A1 0.0072
511 5-hydroxytryptamine 1F receptor HTR1F 0.0071
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0071
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.007
2230 Catalase CAT 0.0069
3249 Catalase katA 0.0069
3625 Catalase katA 0.0069
4539 Catalase katA 0.0069
4941 Catalase katB 0.0069
49 Endothelin B receptor EDNRB 0.0069
780 Retinoic acid receptor RXR-gamma RXRG 0.0069
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
2112 Toll-like receptor 9 TLR9 0.0069
738 Monocarboxylate transporter 1 SLC16A1 0.0068
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0068
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0066
4203 Histamine N-methyltransferase HNMT 0.0066
239 Coagulation factor X F10 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
444 Alcohol dehydrogenase 1B ADH1B 0.0065
273 Apoptosis regulator Bcl-2 BCL2 0.0064
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0064
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0064
6174 50S ribosomal protein L32 rpmF 0.0064
88 Retinoic acid receptor RXR-beta RXRB 0.0063
133 Dihydropterate synthase sulI 0.0063
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
1275 Estrogen sulfotransferase SULT1E1 0.0062
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0062
814 Ryanodine receptor 1 RYR1 0.0062
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0061
153 Dopamine beta-hydroxylase DBH 0.0061
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.006
208 DNA-directed RNA polymerase beta' chain rpoC 0.0059
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0059
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0059
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0059
823 Fibroblast growth factor receptor 2 FGFR2 0.0059
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0059
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0059
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0059
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0059
723 Cytosolic phospholipase A2 PLA2G4A 0.0058
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0057
1618 High affinity nerve growth factor receptor NTRK1 0.0057
1517 Beta-3 adrenergic receptor ADRB3 0.0057
856 Vitamin D3 receptor VDR 0.0056
517 Alcohol dehydrogenase 1C ADH1C 0.0056
165 FL cytokine receptor FLT3 0.0056
6432 Transporter snf 0.0056
6506 Stathmin-4 STMN4 0.0055
357 Carbonic anhydrase 2 CA2 0.0055
1050 Bile salt sulfotransferase SULT2A1 0.0055
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0054
6085 Fatty acid-binding protein, intestinal FABP2 0.0053
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0053
1629 Transcription factor AP-1 JUN 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0052
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
7 Nitric oxide synthase, inducible NOS2 0.0051
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0051
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.005
6044 Serum paraoxonase/lactonase 3 PON3 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
768 FK506-binding protein 1A FKBP1A 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0049
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0049
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0049
24 Thymidylate synthase TMP1 0.0049
359 Thymidylate synthase TYMS 0.0049
2626 Thymidylate synthase thyA 0.0049
2729 Thymidylate synthase thyA 0.0049
5352 Thymidylate synthase THYA 0.0049
469 Annexin A1 ANXA1 0.0049
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0049
3809 Estrogen-related receptor gamma ESRRG 0.0048
106 Cannabinoid receptor 2 CNR2 0.0048
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0047
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0047
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0047
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0047
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0047
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0046
33 Cystine/glutamate transporter SLC7A11 0.0046
3086 Plasmepsin-2 Not Available 0.0046
2539 Tubulin alpha-1 chain TUBA4A 0.0046
719 Retinoic acid receptor responder protein 1 RARRES1 0.0046
770 Retinoic acid-induced protein 3 GPRC5A 0.0046
6126 Carbonic anhydrase 7 CA7 0.0046
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
4311 tRNA TRDMT1 0.0045
4325 tRNA trmD 0.0045
4328 tRNA trmD 0.0045
5934 Cytochrome P450 26A1 CYP26A1 0.0045
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0045
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0045
581 Cytochrome P450 2R1 CYP2R1 0.0045
6043 Putative G-protein coupled receptor 44 GPR44 0.0044
6138 Multidrug resistance protein 3 ABCB4 0.0044
904 Glutathione S-transferase P GSTP1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
183 Vascular endothelial growth factor A VEGFA 0.0044
319 Opioid receptor, sigma 1 OPRS1 0.0043
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0042
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0042
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0042
1648 Elastin ELN 0.0041
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0041
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
1630 Integrin beta-2 ITGB2 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
569 Retinal dehydrogenase 2 ALDH1A2 0.004
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.004
1039 Histone deacetylase 9 HDAC9 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
2298 Cytochrome P450-cam camC 0.004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.004
164 Histamine H4 receptor HRH4 0.0039
6146 High affinity copper uptake protein 1 SLC31A1 0.0039
3937 Fatty-acid amide hydrolase FAAH 0.0039
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
1541 Metalloproteinase mmp20 0.0039
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0039
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0039
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0038
611 Retinal dehydrogenase 1 ALDH1A1 0.0038
162 Retinoic acid receptor gamma-1 RARG 0.0038
3639 Thymidine phosphorylase deoA 0.0037
3936 Thymidine phosphorylase TYMP 0.0037
1852 Microtubule-associated protein 2 MAP2 0.0037
3917 Methylenetetrahydrofolate reductase MTHFR 0.0037
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0037
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0037
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
3856 Fibroblast growth factor receptor 3 FGFR3 0.0035
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0035
976 Platelet glycoprotein IX GP9 0.0035
5300 Antigen peptide transporter 1 TAP1 0.0035
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0035
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
4773 Deoxycytidine kinase DCK 0.0035
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0035
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0035
1268 Neuropeptide S receptor NPSR1 0.0035
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0035
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1483 Membrane copper amine oxidase AOC3 0.0035
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0034
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
634 Squalene monooxygenase SQLE 0.0034
7196 Squalene monooxygenase ERG1 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0034
5787 Angiopoietin-1 receptor TEK 0.0034
4226 Uridine phosphorylase 2 UPP2 0.0033
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0033
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0033
1992 Vitamin D-binding protein GC 0.0033
3957 Adenosine deaminase ADA 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
1196 Complement decay-accelerating factor CD55 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
936 Ephrin type-A receptor 2 EPHA2 0.0032
1360 Sphingomyelin phosphodiesterase SMPD1 0.0032
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0032
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0032
6073 Potassium channel subfamily K member 9 KCNK9 0.0032
6072 Potassium channel subfamily K member 3 KCNK3 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
4192 DNA topoisomerase 2-beta TOP2B 0.0031
1262 Corticotropin-lipotropin POMC 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0031
4225 Uridine phosphorylase 1 UPP1 0.0031
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
908 Glutathione S-transferase theta-1 GSTT1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4217 Telomerase reverse transcriptase TERT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
5923 Microtubule-associated protein tau MAPT 0.003
291 Nitric-oxide synthase, endothelial NOS3 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
2808 Chloramphenicol acetyltransferase 3 cat3 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0028
400 Coagulation factor IX F9 0.0027
5461 Coagulation factor IX F9 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
2981 Phospholipase A2, membrane associated PLA2G2A 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
1864 RET proto-oncogene RET 0.0026
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0026
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0026
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0026
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0026
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
3601 Dihydropteroate synthase 1 folP1 0.0025
3807 Dihydropteroate synthase 1 folP1 0.0025
3808 Dihydropteroate synthase 2 folP2 0.0025
267 Plasminogen activator inhibitor 1 SERPINE1 0.0025
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0025
5880 Thrombopoietin receptor MPL 0.0025
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0025
604 Vitamin K-dependent protein Z PROZ 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
4103 Proteasome subunit beta type 2 PSMB2 0.0025
4102 Proteasome subunit beta type 5 PSMB5 0.0025
4101 Proteasome subunit beta type 1 PSMB1 0.0025
751 Potassium channel subfamily K member 6 KCNK6 0.0025
1374 Natriuretic peptides B NPPB 0.0025
1827 Gap junction alpha-1 protein GJA1 0.0025
1908 Vascular cell adhesion protein 1 VCAM1 0.0025
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2207 Rhodopsin RHO 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0023
2320 Thymidine kinase, cytosolic TK1 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
1245 Vitamin K-dependent protein S PROS1 0.0023
422 Vitamin K-dependent protein C PROC 0.0023
6221 Steroid hormone receptor ERR1 ESRRA 0.0023
1341 Histamine H3 receptor HRH3 0.0023
172 Potassium channel subfamily K member 1 KCNK1 0.0023
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
3404 Exotoxin A eta 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0022
896 Glutathione S-transferase Mu 1 GSTM1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0021
1063 Signal transducer and activator of transcription 5B STAT5B 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
2091 Endoplasmin HSP90B1 0.0021
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0021
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0021
572 Integrin alpha-L ITGAL 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
268 Adenosine A2b receptor ADORA2B 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
6149 Solute carrier family 22 member 10 SLC22A10 0.002
448 Vitamin K-dependent gamma-carboxylase GGCX 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
1820 Beta-nerve growth factor NGF 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
1525 Heparin-binding growth factor 2 FGF2 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0019
798 Osteocalcin BGLAP 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6163 Copper-transporting ATPase 2 ATP7B 0.0017
6165 Copper-transporting ATPase 1 ATP7A 0.0017
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
369 Coagulation factor VII F7 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0016
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0016
1243 Cathepsin D CTSD 0.0016
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3830 Calreticulin CALR 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
6034 Hydroxyindole O-methyltransferase ASMT 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6035 Nuclear receptor ROR-beta RORB 0.0015
6036 Eosinophil peroxidase EPX 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0015
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
6859 Protein S100-A4 S100A4 0.0014
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0014
3904 Alanine aminotransferase 2 GPT2 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
765 Indoleamine 2,3-dioxygenase IDO1 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
76 Nitric-oxide synthase, brain NOS1 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
1867 Major prion protein PRNP 0.0008
3221 Cytochrome c4 cc4 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
6218 Pannexin-1 PANX1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
822 Aldose reductase AKR1B1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1507 Cytochrome c CYCS 0.0007
125 DNA polymerase beta POLB 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4916 Cyanoglobin glbN 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4984 Neuroglobin NGB 0.0006
4943 Cytochrome c6 petJ 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
3116 Bacterioferritin bfr 0.0006
4906 Bacterioferritin bfr 0.0006
4965 Bacterioferritin bfr 0.0006
4910 Cytoglobin CYGB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
5000 HemO hemO 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4909 CooA protein cooA 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4942 Diheme cytochrome c napB napB 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4961 Hemophore HasA hasA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4972 P450cin cinA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
3093 Catalase HPII katE 0.0006
4952 Catalase/peroxidase katA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
358 Cystathionine beta-synthase CBS 0.0003
693 Hemoglobin subunit beta HBB 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
↑