DT-Web

DB00205 - Pyrimethamine


Identification
Name Pyrimethamine
Accession Number DB00205 (APRD00599)
Type small molecule
Description One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 248.711
Groups approved
Monoisotopic Weight 248.082874143
Pharmacology
Indication For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Mechanism of action Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.
Absorption Well absorbed with peak levels occurring between 2 to 6 hours following administration
Protein binding 87%
Biotransformation Hepatic
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Plasmodium
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Pyrimethamine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Lumefantrine Pyrimethamine may increase the adverse effects of lumefantrine. Combination therapy is contraindicated unless there are no other treatment options.
Tamoxifen Pyrimethamine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin Pyrimethamine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Pyrimethamine is initiated, discontinued, or dose changed.
Tramadol Pyrimethamine may decrease the effect of Tramadol by decreasing active metabolite production.
Food Interactions
  • Take with food to reduce irritation.
  • Folic acid needs increased.

Targets


Dihydrofolate reductase
Name Dihydrofolate reductase
Gene Name DHFR
Pharmacological action yes
Actions inhibitor
References
  • Rastelli G, Pacchioni S, Parenti MD: Structure of Plasmodium vivax dihydrofolate reductase determined by homology modeling and molecular dynamics refinement. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3257-60. - Pubmed
  • Fidock DA, Wellems TE: Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6. - Pubmed
  • Wooden JM, Hartwell LH, Vasquez B, Sibley CH: Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum. Mol Biochem Parasitol. 1997 Mar;85(1):25-40. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1394
Bifunctional dihydrofolate reductase-thymidylate synthase
Name Bifunctional dihydrofolate reductase-thymidylate synthase
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Fohl LM, Roos DS: Fitness effects of DHFR-TS mutations associated with pyrimethamine resistance in apicomplexan parasites. Mol Microbiol. 2003 Nov;50(4):1319-27. - Pubmed
  • McKie JH, Douglas KT, Chan C, Roser SA, Yates R, Read M, Hyde JE, Dascombe MJ, Yuthavong Y, Sirawaraporn W: Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria. J Med Chem. 1998 Apr 23;41(9):1367-70. - Pubmed
  • Zolg JW, Plitt JR, Chen GX, Palmer S: Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum. Mol Biochem Parasitol. 1989 Oct;36(3):253-62. - Pubmed
  • Zhang K, Rathod PK: Divergent regulation of dihydrofolate reductase between malaria parasite and human host. Science. 2002 Apr 19;296(5567):545-7. - Pubmed
DTHybrid score 0.4765

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3737
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3627
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2742

Predictions


Id Partner name Gene Name Score
2381 Dihydrofolate reductase DFR1 1.1394
2833 Dihydrofolate reductase Not Available 1.1394
2931 Dihydrofolate reductase folA 1.1394
3544 Dihydrofolate reductase folA 1.1394
3682 Dihydrofolate reductase folA 1.1394
6642 Dihydrofolate reductase folA 1.1394
6756 Dihydrofolate reductase dfrA 1.1394
4512 Cytochrome P450 3A4 CYP3A4 0.2377
4116 Dihydropteroate synthetase Not Available 0.187
6016 Cytochrome P450 2C19 CYP2C19 0.1858
4200 Cytochrome P450 1A2 CYP1A2 0.142
1588 Multidrug resistance protein 1 ABCB1 0.1071
6013 Cytochrome P450 2E1 CYP2E1 0.0973
6236 Trimethoprim-sensitive dihydrofolate reductase dfrB 0.0961
4118 Cytochrome P450 3A5 CYP3A5 0.0869
6030 Cytochrome P450 2B6 CYP2B6 0.0856
6107 Cytochrome P450 3A7 CYP3A7 0.0669
20 Prostaglandin G/H synthase 1 PTGS1 0.0602
5718 Cytochrome P450 2A6 CYP2A6 0.0516
6024 Cytochrome P450 1A1 CYP1A1 0.0488
587 Serum albumin ALB 0.0474
1124 Sepiapterin reductase SPR 0.0413
492 Histamine H1 receptor HRH1 0.0403
24 Thymidylate synthase TMP1 0.039
359 Thymidylate synthase TYMS 0.039
2626 Thymidylate synthase thyA 0.039
2729 Thymidylate synthase thyA 0.039
5352 Thymidylate synthase THYA 0.039
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0374
1650 Heme carrier protein 1 SLC46A1 0.0345
824 Sodium-dependent serotonin transporter SLC6A4 0.0341
6106 Cytochrome P450 2C18 CYP2C18 0.0333
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0318
290 Prostaglandin G/H synthase 2 PTGS2 0.0313
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0296
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0281
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0267
502 5-hydroxytryptamine 2A receptor HTR2A 0.0266
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0265
831 D(2) dopamine receptor DRD2 0.026
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0249
1729 Solute carrier family 22 member 6 SLC22A6 0.0243
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0231
862 Multidrug resistance-associated protein 1 ABCC1 0.023
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.023
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0228
766 Beta-2 adrenergic receptor ADRB2 0.0227
556 Alpha-1A adrenergic receptor ADRA1A 0.0215
713 Sodium-dependent dopamine transporter SLC6A3 0.0197
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0196
1898 Cytochrome P450 1B1 CYP1B1 0.0191
6145 Solute carrier family 22 member 1 SLC22A1 0.0191
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0191
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0189
847 Mu-type opioid receptor OPRM1 0.0189
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0188
193 Beta-1 adrenergic receptor ADRB1 0.0186
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0175
2164 Multidrug resistance-associated protein 4 ABCC4 0.0174
590 5-hydroxytryptamine 2C receptor HTR2C 0.0167
696 Kappa-type opioid receptor OPRK1 0.0167
467 Delta-type opioid receptor OPRD1 0.0166
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0164
891 Dihydropteroate synthase folP 0.0158
5359 Dihydropteroate synthase folP 0.0158
7175 Dihydropteroate synthase sulI 0.0158
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0158
118 Organic cation/carnitine transporter 2 SLC22A5 0.0157
6144 Solute carrier family 22 member 2 SLC22A2 0.0154
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0152
341 5-hydroxytryptamine 3 receptor HTR3A 0.0152
3811 Cytochrome P450 19A1 CYP19A1 0.0146
320 5-hydroxytryptamine 1A receptor HTR1A 0.0145
23 D(1A) dopamine receptor DRD1 0.0144
318 Alpha-2A adrenergic receptor ADRA2A 0.0144
776 Bile salt export pump ABCB11 0.0144
6142 Solute carrier family 22 member 8 SLC22A8 0.0143
3941 Amine oxidase [flavin-containing] A MAOA 0.0139
632 Alpha-1B adrenergic receptor ADRA1B 0.0137
136 Estrogen receptor ESR1 0.0134
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0133
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0128
731 HIV-1 protease HIV-1 protease 0.0128
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0126
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0126
465 Calmodulin CALM1 0.0126
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0126
6143 Solute carrier family 22 member 7 SLC22A7 0.0124
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0123
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0116
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0116
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0116
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0111
70 Type-1 angiotensin II receptor AGTR1 0.0111
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0108
3939 Amine oxidase [flavin-containing] B MAOB 0.0106
122 P2Y purinoceptor 12 P2RY12 0.0105
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0105
1024 Solute carrier family 22 member 11 SLC22A11 0.0104
6031 Cytochrome P450 3A43 CYP3A43 0.0104
6182 Cytochrome P450 2J2 CYP2J2 0.0103
638 D(3) dopamine receptor DRD3 0.01
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0097
4773 Deoxycytidine kinase DCK 0.0095
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0094
833 Organic cation/carnitine transporter 1 SLC22A4 0.0093
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0093
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0092
6147 Solute carrier family 22 member 3 SLC22A3 0.0092
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0092
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.009
146 Androgen receptor AR 0.0089
468 Cytochrome P450 4A11 CYP4A11 0.0088
380 Cytochrome P450 17A1 CYP17A1 0.0088
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0086
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0083
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0083
885 5-hydroxytryptamine 1B receptor HTR1B 0.0082
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0079
436 5-hydroxytryptamine 2B receptor HTR2B 0.0078
94 5-hydroxytryptamine 4 receptor HTR4 0.0078
6102 Arylamine N-acetyltransferase 2 NAT2 0.0077
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0077
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0077
504 Mast/stem cell growth factor receptor KIT 0.0074
629 Alpha-2B adrenergic receptor ADRA2B 0.0074
432 D(4) dopamine receptor DRD4 0.0074
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0072
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
871 Glucocorticoid receptor NR3C1 0.0071
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.007
260 Cytochrome P450 51 ERG11 0.007
761 Cytochrome P450 51 ERG11 0.007
3163 Cytochrome P450 51 cyp51 0.007
789 Alpha-1D adrenergic receptor ADRA1D 0.0069
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0069
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0068
6136 Multidrug resistance-associated protein 5 ABCC5 0.0067
6141 Sodium/bile acid cotransporter SLC10A1 0.0067
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0067
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0066
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0065
811 Translocator protein TSPO 0.0065
474 Acetylcholinesterase ACHE 0.0064
817 DNA topoisomerase 2-alpha TOP2A 0.0063
738 Monocarboxylate transporter 1 SLC16A1 0.0063
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0063
844 Epidermal growth factor receptor EGFR 0.0063
133 Dihydropterate synthase sulI 0.0063
6148 Multidrug resistance-associated protein 7 ABCC10 0.0062
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0062
725 5-hydroxytryptamine 1D receptor HTR1D 0.0061
378 Alpha-2C adrenergic receptor ADRA2C 0.0061
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0061
2112 Toll-like receptor 9 TLR9 0.0061
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.006
4203 Histamine N-methyltransferase HNMT 0.006
1541 Metalloproteinase mmp20 0.006
4120 NADPH--cytochrome P450 reductase POR 0.006
3810 Catechol O-methyltransferase COMT 0.0057
4604 Liver carboxylesterase 1 CES1 0.0056
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0056
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0055
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0054
6085 Fatty acid-binding protein, intestinal FABP2 0.0053
163 D(1B) dopamine receptor DRD5 0.0053
131 Synaptic vesicular amine transporter SLC18A2 0.0053
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0052
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0052
6137 Multidrug resistance-associated protein 6 ABCC6 0.0052
407 Vascular endothelial growth factor receptor 2 KDR 0.0052
1757 Myeloperoxidase MPO 0.005
295 Carbonic anhydrase 1 CA1 0.005
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0049
208 DNA-directed RNA polymerase beta' chain rpoC 0.0049
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0049
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0049
3923 Cholinesterase BCHE 0.0049
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0049
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0048
952 Dipeptidyl peptidase 4 DPP4 0.0048
869 Estrogen receptor beta ESR2 0.0047
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0047
1010 Cytochrome P450 51A1 CYP51A1 0.0047
1275 Estrogen sulfotransferase SULT1E1 0.0047
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0046
88 Retinoic acid receptor RXR-beta RXRB 0.0046
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0045
527 Prostacyclin receptor PTGIR 0.0045
614 Progesterone receptor PGR 0.0045
124 Histamine H2 receptor HRH2 0.0045
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0044
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0044
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0044
49 Endothelin B receptor EDNRB 0.0044
275 Arachidonate 5-lipoxygenase ALOX5 0.0043
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0043
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0043
161 Tubulin beta chain TUBB 0.0043
312 Tubulin beta chain TUB2 0.0043
777 Tumor necrosis factor TNF 0.0042
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0042
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0042
6220 Aryl hydrocarbon receptor AHR 0.0042
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0041
1629 Transcription factor AP-1 JUN 0.0041
29 Tubulin beta-1 chain TUBB1 0.0041
592 Carbonic anhydrase 4 CA4 0.0041
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0041
1050 Bile salt sulfotransferase SULT2A1 0.0041
427 Substance-P receptor TACR1 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
1178 Adenosine A2a receptor ADORA2A 0.0041
716 5-hydroxytryptamine 7 receptor HTR7 0.0041
373 Transthyretin TTR 0.0041
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0041
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0041
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.004
2159 Quinone oxidoreductase CRYZ 0.004
228 Beta platelet-derived growth factor receptor PDGFRB 0.004
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0039
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0038
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0038
518 Peroxidase/catalase T katG 0.0038
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0038
1648 Elastin ELN 0.0037
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0037
26 Vascular endothelial growth factor receptor 3 FLT4 0.0037
130 Prostacyclin synthase PTGIS 0.0037
6014 Cytochrome P450 2A13 CYP2A13 0.0036
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
3086 Plasmepsin-2 Not Available 0.0036
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0036
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0035
32 Vascular endothelial growth factor receptor 1 FLT1 0.0035
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0035
1656 CYP2B protein CYP2B 0.0035
174 Sigma 1-type opioid receptor SIGMAR1 0.0035
1256 5-hydroxytryptamine 6 receptor HTR6 0.0034
6126 Carbonic anhydrase 7 CA7 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
6506 Stathmin-4 STMN4 0.0033
6020 Aldehyde oxidase AOX1 0.0033
173 Toll-like receptor 7 TLR7 0.0033
5880 Thrombopoietin receptor MPL 0.0033
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0032
4122 Histone deacetylase 2 HDAC2 0.0032
482 Glycine receptor subunit alpha-1 GLRA1 0.0032
16 Adenosine A1 receptor ADORA1 0.0032
528 5-hydroxytryptamine 1E receptor HTR1E 0.0032
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0032
634 Squalene monooxygenase SQLE 0.0031
7196 Squalene monooxygenase ERG1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
357 Carbonic anhydrase 2 CA2 0.0031
756 Sex hormone-binding globulin SHBG 0.0031
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.003
162 Retinoic acid receptor gamma-1 RARG 0.003
6103 Arylamine N-acetyltransferase 1 NAT1 0.003
1192 Sulfotransferase 1A1 SULT1A1 0.003
3856 Fibroblast growth factor receptor 3 FGFR3 0.003
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.003
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.003
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0029
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0029
183 Vascular endothelial growth factor A VEGFA 0.0029
823 Fibroblast growth factor receptor 2 FGFR2 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
921 Glutamate receptor 2 GRIA2 0.0029
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
1618 High affinity nerve growth factor receptor NTRK1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0027
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0027
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0027
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0027
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0027
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0027
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0027
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0027
5818 Folate receptor alpha FOLR1 0.0027
780 Retinoic acid receptor RXR-gamma RXRG 0.0027
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0027
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0027
3917 Methylenetetrahydrofolate reductase MTHFR 0.0026
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0026
54 Prothrombin F2 0.0026
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
581 Cytochrome P450 2R1 CYP2R1 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0026
4311 tRNA TRDMT1 0.0026
4325 tRNA trmD 0.0026
4328 tRNA trmD 0.0026
164 Histamine H4 receptor HRH4 0.0026
6174 50S ribosomal protein L32 rpmF 0.0025
4238 50S ribosomal protein L4 rplD 0.0025
5578 50S ribosomal protein L4 rplD 0.0025
6173 50S ribosomal protein L4 rplD 0.0025
6219 50S ribosomal protein L4 rplD 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
84 Nuclear receptor 0B1 NR0B1 0.0025
3947 Xanthine dehydrogenase/oxidase XDH 0.0025
1196 Complement decay-accelerating factor CD55 0.0025
3809 Estrogen-related receptor gamma ESRRG 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
6146 High affinity copper uptake protein 1 SLC31A1 0.0025
1992 Vitamin D-binding protein GC 0.0025
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0024
165 FL cytokine receptor FLT3 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
153 Dopamine beta-hydroxylase DBH 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
6138 Multidrug resistance protein 3 ABCB4 0.0024
5300 Antigen peptide transporter 1 TAP1 0.0024
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0024
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0024
229 Retinoic acid receptor beta RARB 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0024
730 Retinoic acid receptor alpha RARA 0.0023
293 Gamma-glutamyl hydrolase GGH 0.0023
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0023
469 Annexin A1 ANXA1 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
976 Platelet glycoprotein IX GP9 0.0023
1630 Integrin beta-2 ITGB2 0.0023
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0022
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0022
2808 Chloramphenicol acetyltransferase 3 cat3 0.0022
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0022
814 Ryanodine receptor 1 RYR1 0.0022
1262 Corticotropin-lipotropin POMC 0.0021
3932 Glutathione S-transferase A2 GSTA2 0.0021
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0021
2981 Phospholipase A2, membrane associated PLA2G2A 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.002
5787 Angiopoietin-1 receptor TEK 0.002
273 Apoptosis regulator Bcl-2 BCL2 0.002
3808 Dihydropteroate synthase 2 folP2 0.002
3601 Dihydropteroate synthase 1 folP1 0.002
3807 Dihydropteroate synthase 1 folP1 0.002
444 Alcohol dehydrogenase 1B ADH1B 0.002
2417 Chloramphenicol acetyltransferase cat 0.002
3278 Chloramphenicol acetyltransferase cat 0.002
6048 Troponin C, skeletal muscle TNNC2 0.002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.002
2810 Dr hemagglutinin structural subunit draA 0.002
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.002
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.002
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.002
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0019
563 Thyroid peroxidase TPO 0.0019
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0019
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0019
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0019
268 Adenosine A2b receptor ADORA2B 0.0019
646 Malate dehydrogenase, cytoplasmic MDH1 0.0019
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0019
666 NADP-dependent malic enzyme ME1 0.0019
6044 Serum paraoxonase/lactonase 3 PON3 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0018
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
856 Vitamin D3 receptor VDR 0.0018
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0018
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0018
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0018
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0018
5332 MtdA bifunctional protein mtdA 0.0018
4403 Protein iolS iolS 0.0018
5322 Oxidoreductase ydhF ydhF 0.0018
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0018
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0018
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0018
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0018
5330 General stress protein 69 yhdN 0.0018
3778 NAD(P) transhydrogenase subunit beta pntB 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0018
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0018
1341 Histamine H3 receptor HRH3 0.0018
572 Integrin alpha-L ITGAL 0.0017
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0017
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0017
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
6149 Solute carrier family 22 member 10 SLC22A10 0.0017
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0017
569 Retinal dehydrogenase 2 ALDH1A2 0.0016
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0016
473 L-lactate dehydrogenase A chain LDHA 0.0016
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0016
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0016
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0016
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0016
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0016
7 Nitric oxide synthase, inducible NOS2 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
4217 Telomerase reverse transcriptase TERT 0.0016
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0016
4582 Putative pteridine reductase 2 ptr2 0.0016
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0016
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0016
5073 Ferredoxin--NADP reductase petH 0.0016
5076 Ferredoxin--NADP reductase fpr 0.0016
5119 Ferredoxin--NADP reductase petH 0.0016
5121 Ferredoxin--NADP reductase fpr 0.0016
611 Retinal dehydrogenase 1 ALDH1A1 0.0016
5328 Prostaglandin F synthase Tb11.02.2310 0.0016
989 L-xylulose reductase DCXR 0.0016
3446 NADP-dependent alcohol dehydrogenase adh 0.0016
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0016
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0016
2636 Shikimate dehydrogenase aroE 0.0016
3515 Shikimate dehydrogenase aroE 0.0016
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0016
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0016
2286 Isocitrate dehydrogenase [NADP] icd 0.0016
2302 Isocitrate dehydrogenase [NADP] icd 0.0016
2771 Isocitrate dehydrogenase [NADP] icd 0.0016
654 Flavin reductase BLVRB 0.0016
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
2216 Fibroblast growth factor receptor 4 FGFR4 0.0015
758 Thyroid hormone receptor alpha THRA 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
239 Coagulation factor X F10 0.0015
5934 Cytochrome P450 26A1 CYP26A1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
751 Potassium channel subfamily K member 6 KCNK6 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0015
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0015
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0015
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0015
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0015
6297 Prostaglandin reductase 1 PTGR1 0.0015
4531 Putative ketoacyl reductase actIII 0.0015
3062 Aspartate-semialdehyde dehydrogenase asd 0.0014
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0014
2539 Tubulin alpha-1 chain TUBA4A 0.0014
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
3937 Fatty-acid amide hydrolase FAAH 0.0014
2675 Pteridine reductase 1 PTR1 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0014
172 Potassium channel subfamily K member 1 KCNK1 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0014
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0014
2207 Rhodopsin RHO 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
2232 Interleukin-5 IL5 0.0014
1291 cAMP response element-binding protein CREB1 0.0014
1593 Mucin-2 MUC2 0.0014
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0013
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0013
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0013
2021 Thrombomodulin THBD 0.0013
3404 Exotoxin A eta 0.0013
1374 Natriuretic peptides B NPPB 0.0013
1827 Gap junction alpha-1 protein GJA1 0.0013
1908 Vascular cell adhesion protein 1 VCAM1 0.0013
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0013
4210 Toll-like receptor 4 TLR4 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0013
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0013
489 Monocarboxylate transporter 2 SLC16A7 0.0013
904 Glutathione S-transferase P GSTP1 0.0013
3957 Adenosine deaminase ADA 0.0013
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0013
822 Aldose reductase AKR1B1 0.0013
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
5798 Mitogen-activated protein kinase 11 MAPK11 0.0013
5923 Microtubule-associated protein tau MAPT 0.0013
5924 Microtubule-associated protein 4 MAP4 0.0013
2320 Thymidine kinase, cytosolic TK1 0.0012
511 5-hydroxytryptamine 1F receptor HTR1F 0.0012
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
6432 Transporter snf 0.0012
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
1852 Microtubule-associated protein 2 MAP2 0.0012
705 Glutamate receptor 1 GRIA1 0.0012
6824 Tyrosine-protein kinase Lyn LYN 0.0012
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
6218 Pannexin-1 PANX1 0.0011
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
760 Fibroblast growth factor 1 FGF1 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
1039 Histone deacetylase 9 HDAC9 0.0011
106 Cannabinoid receptor 2 CNR2 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
1483 Membrane copper amine oxidase AOC3 0.001
68 Cannabinoid receptor 1 CNR1 0.001
283 SEC14-like protein 2 SEC14L2 0.001
144 Hemoglobin subunit alpha HBA1 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
1864 RET proto-oncogene RET 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
936 Ephrin type-A receptor 2 EPHA2 0.001
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.001
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.001
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
735 Alanine aminotransferase 1 GPT 0.0009
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0009
3904 Alanine aminotransferase 2 GPT2 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4948 Cytochrome c-553 Not Available 0.0009
4923 Cytochrome c3 DvMF_2499 0.0009
4945 Cytochrome c3 Not Available 0.0009
4949 Cytochrome c3 DVU_3171 0.0009
4968 Cytochrome c3 cytc3 0.0009
4997 Cytochrome c3 SO_2727 0.0009
5219 Cytochrome c3 cyd 0.0009
4902 Nine-heme cytochrome c Ddes_2038 0.0009
3189 High-molecular-weight cytochrome c hmcA 0.0009
6677 Myelin P2 protein PMP2 0.0009
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0009
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0009
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0008
284 DNA-directed RNA polymerase beta chain rpoB 0.0008
5773 DNA-directed RNA polymerase beta chain rpoB 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0008
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0008
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0008
291 Nitric-oxide synthase, endothelial NOS3 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
3830 Calreticulin CALR 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
3221 Cytochrome c4 cc4 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0007
4192 DNA topoisomerase 2-beta TOP2B 0.0007
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
1507 Cytochrome c CYCS 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
828 Phenylalanine-4-hydroxylase PAH 0.0006
3109 Phenylalanine-4-hydroxylase phhA 0.0006
816 Biliverdin reductase A BLVRA 0.0006
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0006
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0006
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
33 Cystine/glutamate transporter SLC7A11 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0005
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0005
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0005
328 Sorbitol dehydrogenase SORD 0.0005
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0005
597 Dihydropteridine reductase QDPR 0.0005
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0005
396 Alcohol dehydrogenase 4 ADH4 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
857 Malate dehydrogenase, mitochondrial MDH2 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0005
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0005
12 Alcohol dehydrogenase class 3 ADH5 0.0005
77 L-lactate dehydrogenase B chain LDHB 0.0005
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0005
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0005
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0005
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0005
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0005
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0005
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0005
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0005
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0005
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0005
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0005
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0005
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0005
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0005
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0005
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0005
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0005
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0005
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0005
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0005
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0005
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0005
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0005
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0005
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0005
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0005
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0005
107 C-4 methylsterol oxidase SC4MOL 0.0005
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0005
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0005
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0005
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0005
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0005
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0005
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0005
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0005
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0005
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0005
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0005
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0005
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0005
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0005
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0005
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0005
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0005
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0005
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0005
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0005
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0005
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0005
3726 D-3-phosphoglycerate dehydrogenase serA 0.0005
4291 D-3-phosphoglycerate dehydrogenase serA 0.0005
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0005
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0005
729 GDP-L-fucose synthetase TSTA3 0.0005
3463 GDP-L-fucose synthetase fcl 0.0005
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0005
167 L-lactate dehydrogenase C chain LDHC 0.0005
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0005
206 3-keto-steroid reductase HSD17B7 0.0005
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0005
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0005
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0005
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0005
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0005
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0005
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0005
643 Peroxisomal bifunctional enzyme EHHADH 0.0005
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0005
34 7-dehydrocholesterol reductase DHCR7 0.0005
711 UDP-glucose 6-dehydrogenase UGDH 0.0005
3672 UDP-glucose 6-dehydrogenase hasB 0.0005
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0005
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0005
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0005
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0005
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0005
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0005
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0005
13 Aminomethyltransferase, mitochondrial AMT 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0005
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0005
6026 Alcohol dehydrogenase 6 ADH6 0.0004
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0004
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0004
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0004
626 Cysteine dioxygenase type 1 CDO1 0.0004
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0004
627 11-cis retinol dehydrogenase RDH5 0.0004
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4916 Cyanoglobin glbN 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4943 Cytochrome c6 petJ 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4984 Neuroglobin NGB 0.0004
4909 CooA protein cooA 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4961 Hemophore HasA hasA 0.0004
4910 Cytoglobin CYGB 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
3116 Bacterioferritin bfr 0.0004
4906 Bacterioferritin bfr 0.0004
4965 Bacterioferritin bfr 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4972 P450cin cinA 0.0004
3093 Catalase HPII katE 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4952 Catalase/peroxidase katA 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
714 Glutathione reductase, mitochondrial GSR 0.0004
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0004
6043 Putative G-protein coupled receptor 44 GPR44 0.0004
279 Tyrosinase TYR 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
4920 Peroxidase/catalase katG 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
605 Fumarate reductase flavoprotein subunit frdA 0.0002
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0002
3673 Fumarate reductase flavoprotein subunit fccA 0.0002
4912 Fumarate reductase flavoprotein subunit ifcA 0.0002
6549 Fumarate reductase flavoprotein subunit frdA 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
2298 Cytochrome P450-cam camC 0.0002
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