DT-Web

DB00608 - Chloroquine


Identification
Name Chloroquine
Accession Number DB00608 (APRD00468)
Type small molecule
Description The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 319.872
Groups approved
Monoisotopic Weight 319.181525554
Pharmacology
Indication For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis
Mechanism of action The mechanism of plasmodicidal action of chloroquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites. nside red blood cells, the malarial parasite must degrade hemoglobin to acquire essential amino acids, which the parasite requires to construct its own protein and for energy metabolism. Digestion is carried out in a vacuole of the parasite cell. During this process, the parasite produces the toxic and soluble molecule heme. The heme moiety consists of a porphyrin ring called Fe(II)-protoporphyrin IX (FP). To avoid destruction by this molecule, the parasite biocrystallizes heme to form hemozoin, a non-toxic molecule. Hemozoin collects in the digestive vacuole as insoluble crystals. Chloroquine enters the red blood cell, inhabiting parasite cell, and digestive vacuole by simple diffusion. Chloroquine then becomes protonated (to CQ2+), as the digestive vacuole is known to be acidic (pH 4.7); chloroquine then cannot leave by diffusion. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme (or FP) to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products.
Absorption Completely absorbed from gastrointestinal tract
Protein binding ~55% of the drug in the plasma is bound to nondiffusible plasma constituents
Biotransformation Hepatic (partially)
Route of elimination Excretion of chloroquine is quite slow, but is increased by acidification of the urine.
Toxicity Not Available
Affected organisms
  • Plasmodium
Interactions
Drug Interactions
Drug Mechanism of interaction
Aluminium The antiacid decreases the absorption of chloroquine
Artemether Chloroquine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Atomoxetine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Attapulgite The antiacid decreases the absorption of chloroquine
Calcium The antiacid decreases the absorption of chloroquine
Cyclosporine Chloroquine may increase the therapeutic and adverse effects of cyclosporine.
Dihydroxyaluminium The antiacid decreases the absorption of chloroquine
Kaolin The antiacid decreases the absorption of chloroquine
Lumefantrine Chloroquine may increase the adverse effects of lumefantrine. Combination therapy is contraindicated unless there are no other treatment options.
Magnesium The antiacid decreases the absorption of chloroquine
Magnesium oxide The antiacid decreases the absorption of chloroquine
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Praziquantel Markedly lower praziquantel levels
Tamoxifen Chloroquine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin Chloroquine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Chloroquine is initiated, discontinued, or dose changed.
Telithromycin Telithromycin may reduce clearance of Chloroquine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Chloroquine if Telithromycin is initiated, discontinued or dose changed.
Terbinafine Terbinafine may reduce the metabolism and clearance of Chloroquine. Consider alternate therapy or monitor for therapeutic/adverse effects of Chloroquine if Terbinafine is initiated, discontinued or dose changed.
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Tramadol Chloroquine may decrease the effect of Tramadol by decreasing active metabolite production.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of chloroquine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of chloroquine if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take with food to reduce irritation and increase bioavailability.

Targets


Ferriprotoporphyrin IX
Name Ferriprotoporphyrin IX
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Fitch CD: Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs. Life Sci. 2004 Mar 5;74(16):1957-72. - Pubmed
  • Dorn A, Vippagunta SR, Matile H, Jaquet C, Vennerstrom JL, Ridley RG: An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials. Biochem Pharmacol. 1998 Mar 15;55(6):727-36. - Pubmed
  • Stoller TJ, Shields D: The propeptide of preprosomatostatin mediates intracellular transport and secretion of alpha-globin from mammalian cells. J Cell Biol. 1989 May;108(5):1647-55. - Pubmed
  • Mockenhaupt FP, May J, Bergqvist Y, Meyer CG, Falusi AG, Bienzle U: Evidence for a reduced effect of chloroquine against Plasmodium falciparum in alpha-thalassaemic children. Trop Med Int Health. 2001 Feb;6(2):102-7. - Pubmed
DTHybrid score Not Available
Glutathione S-transferase A2
Name Glutathione S-transferase A2
Gene Name GSTA2
Pharmacological action unknown
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.2496
Tumor necrosis factor
Name Tumor necrosis factor
Gene Name TNF
Pharmacological action unknown
Actions Not Available
References
  • Jang CH, Choi JH, Byun MS, Jue DM: Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes. Rheumatology (Oxford). 2006 Jun;45(6):703-10. Epub 2006 Jan 17. - Pubmed
  • Rachmilewitz D, Karmeli F, Shteingart S, Lee J, Takabayashi K, Raz E: Immunostimulatory oligonucleotides inhibit colonic proinflammatory cytokine production in ulcerative colitis. Inflamm Bowel Dis. 2006 May;12(5):339-45. - Pubmed
  • Wozniacka A, Lesiak A, Narbutt J, McCauliffe DP, Sysa-Jedrzejowska A: Chloroquine treatment influences proinflammatory cytokine levels in systemic lupus erythematosus patients. Lupus. 2006;15(5):268-75. - Pubmed
  • Lim EJ, Lee SH, Lee JG, Chin BR, Bae YS, Kim JR, Lee CH, Baek SH: Activation of toll-like receptor-9 induces matrix metalloproteinase-9 expression through Akt and tumor necrosis factor-alpha signaling. FEBS Lett. 2006 Aug 7;580(18):4533-8. Epub 2006 Jul 17. - Pubmed
  • Dias-Melicio LA, Calvi SA, Bordon AP, Golim MA, Peracoli MT, Soares AM: Chloroquine is therapeutic in murine experimental model of paracoccidioidomycosis. FEMS Immunol Med Microbiol. 2007 Jun;50(1):133-43. Epub 2007 Apr 23. - Pubmed
DTHybrid score 0.7422
Toll-like receptor 9
Name Toll-like receptor 9
Gene Name TLR9
Pharmacological action unknown
Actions Not Available
References
  • Trevani AS, Chorny A, Salamone G, Vermeulen M, Gamberale R, Schettini J, Raiden S, Geffner J: Bacterial DNA activates human neutrophils by a CpG-independent pathway. Eur J Immunol. 2003 Nov;33(11):3164-74. - Pubmed
  • Rutz M, Metzger J, Gellert T, Luppa P, Lipford GB, Wagner H, Bauer S: Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur J Immunol. 2004 Sep;34(9):2541-50. - Pubmed
  • Lenert P: Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases? Clin Exp Immunol. 2005 Apr;140(1):1-10. - Pubmed
  • Huang LY, Ishii KJ, Akira S, Aliberti J, Golding B: Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9. J Immunol. 2005 Sep 15;175(6):3964-70. - Pubmed
  • Merrell MA, Ilvesaro JM, Lehtonen N, Sorsa T, Gehrs B, Rosenthal E, Chen D, Shackley B, Harris KW, Selander KS: Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity. Mol Cancer Res. 2006 Jul;4(7):437-47. - Pubmed
DTHybrid score 0.4955

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6706
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5349
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3131
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3315
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3677

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
DTHybrid score 0.4546

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.2746
4200 Cytochrome P450 1A2 CYP1A2 0.2707
6016 Cytochrome P450 2C19 CYP2C19 0.2405
173 Toll-like receptor 7 TLR7 0.2381
6107 Cytochrome P450 3A7 CYP3A7 0.1991
6013 Cytochrome P450 2E1 CYP2E1 0.1534
6030 Cytochrome P450 2B6 CYP2B6 0.1531
5718 Cytochrome P450 2A6 CYP2A6 0.0997
587 Serum albumin ALB 0.0948
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0944
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0713
4031 Glutathione S-transferase A1 GSTA1 0.0666
20 Prostaglandin G/H synthase 1 PTGS1 0.0657
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0619
492 Histamine H1 receptor HRH1 0.0609
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0593
290 Prostaglandin G/H synthase 2 PTGS2 0.059
1898 Cytochrome P450 1B1 CYP1B1 0.0579
1729 Solute carrier family 22 member 6 SLC22A6 0.0575
862 Multidrug resistance-associated protein 1 ABCC1 0.0565
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0552
896 Glutathione S-transferase Mu 1 GSTM1 0.0522
824 Sodium-dependent serotonin transporter SLC6A4 0.0518
766 Beta-2 adrenergic receptor ADRB2 0.0517
193 Beta-1 adrenergic receptor ADRB1 0.0506
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0483
6106 Cytochrome P450 2C18 CYP2C18 0.0478
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0455
831 D(2) dopamine receptor DRD2 0.0454
6145 Solute carrier family 22 member 1 SLC22A1 0.0446
871 Glucocorticoid receptor NR3C1 0.0443
556 Alpha-1A adrenergic receptor ADRA1A 0.0443
468 Cytochrome P450 4A11 CYP4A11 0.0429
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0427
502 5-hydroxytryptamine 2A receptor HTR2A 0.0418
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0412
4041 Microsomal glutathione S-transferase 2 MGST2 0.0402
776 Bile salt export pump ABCB11 0.0401
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.039
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0384
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0379
6144 Solute carrier family 22 member 2 SLC22A2 0.0376
847 Mu-type opioid receptor OPRM1 0.0366
3811 Cytochrome P450 19A1 CYP19A1 0.0361
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0359
904 Glutathione S-transferase P GSTP1 0.0351
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0333
320 5-hydroxytryptamine 1A receptor HTR1A 0.0329
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0326
136 Estrogen receptor ESR1 0.0324
318 Alpha-2A adrenergic receptor ADRA2A 0.0318
1820 Beta-nerve growth factor NGF 0.0317
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0316
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0307
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0302
558 Solute carrier family 12 member 1 SLC12A1 0.0299
467 Delta-type opioid receptor OPRD1 0.0299
3947 Xanthine dehydrogenase/oxidase XDH 0.0296
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0296
118 Organic cation/carnitine transporter 2 SLC22A5 0.0292
1517 Beta-3 adrenergic receptor ADRB3 0.0286
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0278
632 Alpha-1B adrenergic receptor ADRA1B 0.0274
696 Kappa-type opioid receptor OPRK1 0.0273
3090 Chitosanase csn 0.0265
1405 Thiopurine S-methyltransferase TPMT 0.0265
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0265
23 D(1A) dopamine receptor DRD1 0.0263
590 5-hydroxytryptamine 2C receptor HTR2C 0.0262
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0259
6142 Solute carrier family 22 member 8 SLC22A8 0.0258
713 Sodium-dependent dopamine transporter SLC6A3 0.0255
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0255
731 HIV-1 protease HIV-1 protease 0.0253
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0252
6031 Cytochrome P450 3A43 CYP3A43 0.025
6182 Cytochrome P450 2J2 CYP2J2 0.0249
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0245
2164 Multidrug resistance-associated protein 4 ABCC4 0.0243
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0237
341 5-hydroxytryptamine 3 receptor HTR3A 0.0237
1253 Interferon gamma IFNG 0.023
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0228
638 D(3) dopamine receptor DRD3 0.0223
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0223
6147 Solute carrier family 22 member 3 SLC22A3 0.0223
6143 Solute carrier family 22 member 7 SLC22A7 0.0222
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0221
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.022
2232 Interleukin-5 IL5 0.0219
1593 Mucin-2 MUC2 0.0218
465 Calmodulin CALM1 0.0215
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0214
2782 Complement C1s subcomponent C1S 0.0213
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0211
817 DNA topoisomerase 2-alpha TOP2A 0.021
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0203
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0202
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0202
844 Epidermal growth factor receptor EGFR 0.0202
833 Organic cation/carnitine transporter 1 SLC22A4 0.0198
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0198
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0197
823 Fibroblast growth factor receptor 2 FGFR2 0.0197
3815 Complement C1q subcomponent subunit A C1QA 0.0197
3816 Complement C1q subcomponent subunit B C1QB 0.0197
3817 Complement C1q subcomponent subunit C C1QC 0.0196
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0194
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0194
3814 Complement C1r subcomponent C1R 0.0194
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0194
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0194
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0192
65 Matrix metalloproteinase-9 Not Available 0.019
885 5-hydroxytryptamine 1B receptor HTR1B 0.0187
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0186
260 Cytochrome P450 51 ERG11 0.0186
761 Cytochrome P450 51 ERG11 0.0186
3163 Cytochrome P450 51 cyp51 0.0186
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0185
3923 Cholinesterase BCHE 0.0184
614 Progesterone receptor PGR 0.0184
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.018
6148 Multidrug resistance-associated protein 7 ABCC10 0.0178
629 Alpha-2B adrenergic receptor ADRA2B 0.0176
1123 Eosinophil cationic protein RNASE3 0.0175
789 Alpha-1D adrenergic receptor ADRA1D 0.0174
3941 Amine oxidase [flavin-containing] A MAOA 0.0171
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0167
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0167
378 Alpha-2C adrenergic receptor ADRA2C 0.0166
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0162
146 Androgen receptor AR 0.016
504 Mast/stem cell growth factor receptor KIT 0.0157
899 Glutathione S-transferase Mu 3 GSTM3 0.0156
905 Glutathione transferase omega-1 GSTO1 0.0156
1789 Lymphotoxin-alpha LTA 0.0156
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0156
725 5-hydroxytryptamine 1D receptor HTR1D 0.0155
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0153
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0151
232 Corticosteroid-binding globulin SERPINA6 0.015
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0149
737 Mineralocorticoid receptor NR3C2 0.0146
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0146
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0146
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0145
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0145
4604 Liver carboxylesterase 1 CES1 0.0143
952 Dipeptidyl peptidase 4 DPP4 0.014
380 Cytochrome P450 17A1 CYP17A1 0.014
6136 Multidrug resistance-associated protein 5 ABCC5 0.0137
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0137
432 D(4) dopamine receptor DRD4 0.0136
2449 Tubulin alpha-3 chain TUBA1A 0.0135
122 P2Y purinoceptor 12 P2RY12 0.0134
4148 Serine/threonine-protein kinase mTOR MTOR 0.0134
6014 Cytochrome P450 2A13 CYP2A13 0.0134
6141 Sodium/bile acid cotransporter SLC10A1 0.0133
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0132
6137 Multidrug resistance-associated protein 6 ABCC6 0.0132
436 5-hydroxytryptamine 2B receptor HTR2B 0.0131
1024 Solute carrier family 22 member 11 SLC22A11 0.0131
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0131
2499 Tubulin beta-2C chain TUBB2C 0.0129
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0127
375 SEC14-like protein 3 SEC14L3 0.0127
86 SEC14-like protein 4 SEC14L4 0.0127
4076 Diacylglycerol kinase alpha DGKA 0.0127
275 Arachidonate 5-lipoxygenase ALOX5 0.0126
474 Acetylcholinesterase ACHE 0.0126
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0125
3939 Amine oxidase [flavin-containing] B MAOB 0.0124
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0124
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0124
283 SEC14-like protein 2 SEC14L2 0.0123
29 Tubulin beta-1 chain TUBB1 0.0123
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0121
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.012
756 Sex hormone-binding globulin SHBG 0.0119
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0118
161 Tubulin beta chain TUBB 0.0117
312 Tubulin beta chain TUB2 0.0117
48 Pyridoxal kinase PDXK 0.0116
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0115
4120 NADPH--cytochrome P450 reductase POR 0.0115
869 Estrogen receptor beta ESR2 0.0113
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0112
1010 Cytochrome P450 51A1 CYP51A1 0.0112
124 Histamine H2 receptor HRH2 0.0112
6220 Aryl hydrocarbon receptor AHR 0.0111
228 Beta platelet-derived growth factor receptor PDGFRB 0.0111
407 Vascular endothelial growth factor receptor 2 KDR 0.0111
811 Translocator protein TSPO 0.0109
4203 Histamine N-methyltransferase HNMT 0.0109
1192 Sulfotransferase 1A1 SULT1A1 0.0108
997 Protein kinase C beta type PRKCB 0.0108
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0108
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0108
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0107
708 Alpha-tocopherol transfer protein TTPA 0.0107
26 Vascular endothelial growth factor receptor 3 FLT4 0.0107
716 5-hydroxytryptamine 7 receptor HTR7 0.0105
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0105
70 Type-1 angiotensin II receptor AGTR1 0.0103
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0102
32 Vascular endothelial growth factor receptor 1 FLT1 0.0102
1970 Protein kinase C alpha type PRKCA 0.0101
818 50S ribosomal protein L10 rplJ 0.0101
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.01
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0099
373 Transthyretin TTR 0.0098
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0098
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0097
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0096
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0095
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0095
477 DNA topoisomerase 4 subunit A parC 0.0094
886 DNA topoisomerase 4 subunit A parC 0.0094
6226 DNA topoisomerase 4 subunit A parC 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0094
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0094
404 DNA gyrase subunit A gyrA 0.0093
6224 DNA gyrase subunit A gyrA 0.0093
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0093
6102 Arylamine N-acetyltransferase 2 NAT2 0.0092
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0091
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.009
613 Atrial natriuretic peptide receptor A NPR1 0.009
1178 Adenosine A2a receptor ADORA2A 0.0089
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0087
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0087
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0087
131 Synaptic vesicular amine transporter SLC18A2 0.0086
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0086
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0085
163 D(1B) dopamine receptor DRD5 0.0085
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0085
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0084
94 5-hydroxytryptamine 4 receptor HTR4 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
1656 CYP2B protein CYP2B 0.0081
810 Heme oxygenase 1 HMOX1 0.008
3391 Heme oxygenase 1 pbsA1 0.008
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.008
4311 tRNA TRDMT1 0.008
4325 tRNA trmD 0.008
4328 tRNA trmD 0.008
814 Ryanodine receptor 1 RYR1 0.008
1629 Transcription factor AP-1 JUN 0.0079
365 Dihydrofolate reductase DHFR 0.0077
2381 Dihydrofolate reductase DFR1 0.0077
2833 Dihydrofolate reductase Not Available 0.0077
2931 Dihydrofolate reductase folA 0.0077
3544 Dihydrofolate reductase folA 0.0077
3682 Dihydrofolate reductase folA 0.0077
6642 Dihydrofolate reductase folA 0.0077
6756 Dihydrofolate reductase dfrA 0.0077
1256 5-hydroxytryptamine 6 receptor HTR6 0.0077
6020 Aldehyde oxidase AOX1 0.0077
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0077
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0077
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0077
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0077
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0077
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0077
2539 Tubulin alpha-1 chain TUBA4A 0.0076
4237 50S ribosomal protein L22 rplV 0.0076
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0076
244 Angiotensin-converting enzyme ACE 0.0076
738 Monocarboxylate transporter 1 SLC16A1 0.0075
5300 Antigen peptide transporter 1 TAP1 0.0075
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0075
239 Coagulation factor X F10 0.0075
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0074
705 Glutamate receptor 1 GRIA1 0.0072
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0072
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0072
16 Adenosine A1 receptor ADORA1 0.0071
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
1757 Myeloperoxidase MPO 0.0071
1353 DNA topoisomerase 1 TOP1 0.007
3552 DNA topoisomerase 1 topA 0.007
4228 Keratin, type II cytoskeletal 7 KRT7 0.007
908 Glutathione S-transferase theta-1 GSTT1 0.007
68 Cannabinoid receptor 1 CNR1 0.007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.007
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.007
1050 Bile salt sulfotransferase SULT2A1 0.0069
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0069
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0069
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0069
3086 Plasmepsin-2 Not Available 0.0068
891 Dihydropteroate synthase folP 0.0067
5359 Dihydropteroate synthase folP 0.0067
7175 Dihydropteroate synthase sulI 0.0067
723 Cytosolic phospholipase A2 PLA2G4A 0.0067
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0067
768 FK506-binding protein 1A FKBP1A 0.0067
165 FL cytokine receptor FLT3 0.0067
2183 Fatty acid-binding protein, adipocyte FABP4 0.0066
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0066
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0066
33 Cystine/glutamate transporter SLC7A11 0.0065
208 DNA-directed RNA polymerase beta' chain rpoC 0.0065
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0065
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0065
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0065
1852 Microtubule-associated protein 2 MAP2 0.0065
295 Carbonic anhydrase 1 CA1 0.0064
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0064
469 Annexin A1 ANXA1 0.0064
6085 Fatty acid-binding protein, intestinal FABP2 0.0064
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0063
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
528 5-hydroxytryptamine 1E receptor HTR1E 0.0063
903 Glutathione S-transferase A5 GSTA5 0.0063
4238 50S ribosomal protein L4 rplD 0.0063
5578 50S ribosomal protein L4 rplD 0.0063
6173 50S ribosomal protein L4 rplD 0.0063
6219 50S ribosomal protein L4 rplD 0.0063
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0063
427 Substance-P receptor TACR1 0.0062
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0062
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0062
856 Vitamin D3 receptor VDR 0.0061
84 Nuclear receptor 0B1 NR0B1 0.0061
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0061
88 Retinoic acid receptor RXR-beta RXRB 0.0061
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.006
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.006
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.006
4103 Proteasome subunit beta type 2 PSMB2 0.006
4102 Proteasome subunit beta type 5 PSMB5 0.006
4101 Proteasome subunit beta type 1 PSMB1 0.006
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
4122 Histone deacetylase 2 HDAC2 0.0059
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
3856 Fibroblast growth factor receptor 3 FGFR3 0.0058
790 DNA polymerase subunit alpha B POLA2 0.0058
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0058
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0058
6043 Putative G-protein coupled receptor 44 GPR44 0.0058
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
6138 Multidrug resistance protein 3 ABCB4 0.0057
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0056
319 Opioid receptor, sigma 1 OPRS1 0.0056
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0056
6766 O-GlcNAcase BT_4395 BT_4395 0.0056
6506 Stathmin-4 STMN4 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0055
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0054
900 Glutathione S-transferase A4 GSTA4 0.0054
976 Platelet glycoprotein IX GP9 0.0054
898 Glutathione S-transferase A3 GSTA3 0.0054
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0054
1714 Mitogen-activated protein kinase 3 MAPK3 0.0054
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0053
4034 Glutaredoxin-1 GLRX 0.0053
820 Glycine receptor subunit alpha-2 GLRA2 0.0053
1928 Leukotriene C4 synthase LTC4S 0.0053
4035 Glutathione S-transferase Mu 5 GSTM5 0.0053
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0053
4040 Glutathione peroxidase 7 GPX7 0.0053
906 Glutathione peroxidase 1 GPX1 0.0053
4036 Glutathione peroxidase 6 GPX6 0.0053
4037 Hypothetical protein GPX1 0.0053
4297 Hypothetical protein SP_1951 0.0053
4521 Hypothetical protein BC_2969 0.0053
4540 Hypothetical protein TM_1070 0.0053
4555 Hypothetical protein MT1739 0.0053
4569 Hypothetical protein mshD 0.0053
4578 Hypothetical protein PA3270 0.0053
4747 Hypothetical protein PA3967 0.0053
5177 Hypothetical protein TM_0096 0.0053
5194 Hypothetical protein PA1204 0.0053
5240 Hypothetical protein Rv2991 0.0053
5370 Hypothetical protein TM_1158 0.0053
5710 Hypothetical protein Tb927.5.1360 0.0053
4029 Microsomal glutathione S-transferase 3 MGST3 0.0053
4032 Microsomal glutathione S-transferase 1 MGST1 0.0053
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0053
907 Glutathione peroxidase 2 GPX2 0.0053
4038 Glutathione peroxidase 4 GPX4 0.0053
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0053
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0053
910 Epididymal secretory glutathione peroxidase GPX5 0.0053
911 Glutathione peroxidase 3 GPX3 0.0053
4042 Glutathione transferase omega-2 GSTO2 0.0053
4033 S-formylglutathione hydrolase ESD 0.0053
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0053
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0053
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
581 Cytochrome P450 2R1 CYP2R1 0.0052
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0051
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0051
54 Prothrombin F2 0.0051
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0051
162 Retinoic acid receptor gamma-1 RARG 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6146 High affinity copper uptake protein 1 SLC31A1 0.005
1541 Metalloproteinase mmp20 0.0049
4192 DNA topoisomerase 2-beta TOP2B 0.0049
24 Thymidylate synthase TMP1 0.0049
359 Thymidylate synthase TYMS 0.0049
2626 Thymidylate synthase thyA 0.0049
2729 Thymidylate synthase thyA 0.0049
5352 Thymidylate synthase THYA 0.0049
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0049
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0048
1176 Mitogen-activated protein kinase 1 MAPK1 0.0047
6174 50S ribosomal protein L32 rpmF 0.0047
174 Sigma 1-type opioid receptor SIGMAR1 0.0047
273 Apoptosis regulator Bcl-2 BCL2 0.0047
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0047
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0047
592 Carbonic anhydrase 4 CA4 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
5934 Cytochrome P450 26A1 CYP26A1 0.0046
897 Glutathione S-transferase kappa 1 GSTK1 0.0046
3319 Hydroxyacylglutathione hydrolase HAGH 0.0046
6824 Tyrosine-protein kinase Lyn LYN 0.0045
1483 Membrane copper amine oxidase AOC3 0.0045
1618 High affinity nerve growth factor receptor NTRK1 0.0045
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0045
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0044
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0044
909 Maleylacetoacetate isomerase GSTZ1 0.0044
3809 Estrogen-related receptor gamma ESRRG 0.0044
106 Cannabinoid receptor 2 CNR2 0.0043
780 Retinoic acid receptor RXR-gamma RXRG 0.0043
5923 Microtubule-associated protein tau MAPT 0.0043
5924 Microtubule-associated protein 4 MAP4 0.0043
5787 Angiopoietin-1 receptor TEK 0.0043
936 Ephrin type-A receptor 2 EPHA2 0.0042
284 DNA-directed RNA polymerase beta chain rpoB 0.0042
5773 DNA-directed RNA polymerase beta chain rpoB 0.0042
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0042
569 Retinal dehydrogenase 2 ALDH1A2 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.004
4773 Deoxycytidine kinase DCK 0.004
2165 Glutathione S-transferase Mu 2 GSTM2 0.004
1992 Vitamin D-binding protein GC 0.0039
3426 Glutamine synthetase glnA 0.0039
3987 Glutamine synthetase GLUL 0.0039
611 Retinal dehydrogenase 1 ALDH1A1 0.0039
634 Squalene monooxygenase SQLE 0.0039
7196 Squalene monooxygenase ERG1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0039
207 Glutathione synthetase GSS 0.0038
5269 Glutathione synthetase gshB 0.0038
1569 G1/S-specific cyclin-D1 CCND1 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
1630 Integrin beta-2 ITGB2 0.0037
1313 Lactoylglutathione lyase GLO1 0.0037
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0037
1063 Signal transducer and activator of transcription 5B STAT5B 0.0037
901 Glutathione S-transferase Mu 4 GSTM4 0.0037
1196 Complement decay-accelerating factor CD55 0.0036
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0036
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0036
153 Dopamine beta-hydroxylase DBH 0.0036
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
921 Glutamate receptor 2 GRIA2 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
1262 Corticotropin-lipotropin POMC 0.0035
357 Carbonic anhydrase 2 CA2 0.0035
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0035
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0035
719 Retinoic acid receptor responder protein 1 RARRES1 0.0035
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0035
770 Retinoic acid-induced protein 3 GPRC5A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0034
758 Thyroid hormone receptor alpha THRA 0.0034
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0034
1374 Natriuretic peptides B NPPB 0.0034
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0034
1827 Gap junction alpha-1 protein GJA1 0.0033
1908 Vascular cell adhesion protein 1 VCAM1 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
518 Peroxidase/catalase T katG 0.0033
5880 Thrombopoietin receptor MPL 0.0033
6432 Transporter snf 0.0033
484 Tyrosine-protein kinase ABL2 ABL2 0.0033
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
6048 Troponin C, skeletal muscle TNNC2 0.0032
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0032
229 Retinoic acid receptor beta RARB 0.0032
482 Glycine receptor subunit alpha-1 GLRA1 0.0032
2808 Chloramphenicol acetyltransferase 3 cat3 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
183 Vascular endothelial growth factor A VEGFA 0.0031
7 Nitric oxide synthase, inducible NOS2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
714 Glutathione reductase, mitochondrial GSR 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
2236 Casein kinase II subunit alpha CSNK2A1 0.0031
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0031
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0031
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0031
268 Adenosine A2b receptor ADORA2B 0.0031
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0031
1648 Elastin ELN 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
1275 Estrogen sulfotransferase SULT1E1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
6126 Carbonic anhydrase 7 CA7 0.003
6044 Serum paraoxonase/lactonase 3 PON3 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
267 Plasminogen activator inhibitor 1 SERPINE1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
164 Histamine H4 receptor HRH4 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
3957 Adenosine deaminase ADA 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.003
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0029
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0029
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0029
2417 Chloramphenicol acetyltransferase cat 0.0029
3278 Chloramphenicol acetyltransferase cat 0.0029
3601 Dihydropteroate synthase 1 folP1 0.0029
3807 Dihydropteroate synthase 1 folP1 0.0029
3808 Dihydropteroate synthase 2 folP2 0.0029
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
2810 Dr hemagglutinin structural subunit draA 0.0029
1525 Heparin-binding growth factor 2 FGF2 0.0028
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0028
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0028
751 Potassium channel subfamily K member 6 KCNK6 0.0028
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
572 Integrin alpha-L ITGAL 0.0028
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0028
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
6221 Steroid hormone receptor ERR1 ESRRA 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
3913 Glutamic acid decarboxylase GAD65 0.0027
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3937 Fatty-acid amide hydrolase FAAH 0.0026
172 Potassium channel subfamily K member 1 KCNK1 0.0026
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
49 Endothelin B receptor EDNRB 0.0026
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0026
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
3810 Catechol O-methyltransferase COMT 0.0024
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0023
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
735 Alanine aminotransferase 1 GPT 0.0023
3904 Alanine aminotransferase 2 GPT2 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
707 72 kDa type IV collagenase MMP2 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
6131 Carbonic anhydrase 14 CA14 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0022
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0022
3404 Exotoxin A eta 0.0022
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0022
298 Renin REN 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0021
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
6122 Carbonic anhydrase 3 CA3 0.002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.002
6459 Glycodelin PAEP 0.002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
1864 RET proto-oncogene RET 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
444 Alcohol dehydrogenase 1B ADH1B 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.002
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.002
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.002
4217 Telomerase reverse transcriptase TERT 0.002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
251 Alcohol dehydrogenase 1A ADH1A 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
3830 Calreticulin CALR 0.0018
489 Monocarboxylate transporter 2 SLC16A7 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
3917 Methylenetetrahydrofolate reductase MTHFR 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
2981 Phospholipase A2, membrane associated PLA2G2A 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
2207 Rhodopsin RHO 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6034 Hydroxyindole O-methyltransferase ASMT 0.0017
6035 Nuclear receptor ROR-beta RORB 0.0017
6036 Eosinophil peroxidase EPX 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0017
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
1039 Histone deacetylase 9 HDAC9 0.0016
822 Aldose reductase AKR1B1 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
5798 Mitogen-activated protein kinase 11 MAPK11 0.0016
3233 Bile acid receptor NR1H4 0.0015
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0015
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
6755 Poliovirus receptor PVR 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
563 Thyroid peroxidase TPO 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
765 Indoleamine 2,3-dioxygenase IDO1 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
422 Vitamin K-dependent protein C PROC 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1341 Histamine H3 receptor HRH3 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0014
6218 Pannexin-1 PANX1 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
2021 Thrombomodulin THBD 0.0013
3007 Carbonic anhydrase 12 CA12 0.0013
4205 Carbonic anhydrase 9 CA9 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
6859 Protein S100-A4 S100A4 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
798 Osteocalcin BGLAP 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.001
369 Coagulation factor VII F7 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
345 Plasma retinol-binding protein RBP4 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
4226 Uridine phosphorylase 2 UPP2 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
4225 Uridine phosphorylase 1 UPP1 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
413 Amidophosphoribosyltransferase PPAT 0.0008
2515 Amidophosphoribosyltransferase purF 0.0008
3714 Amidophosphoribosyltransferase purF 0.0008
1867 Major prion protein PRNP 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2298 Cytochrome P450-cam camC 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
76 Nitric-oxide synthase, brain NOS1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
3639 Thymidine phosphorylase deoA 0.0007
3936 Thymidine phosphorylase TYMP 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
3221 Cytochrome c4 cc4 0.0006
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4943 Cytochrome c6 petJ 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4961 Hemophore HasA hasA 0.0003
4909 CooA protein cooA 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
5000 HemO hemO 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4910 Cytoglobin CYGB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4972 P450cin cinA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
4920 Peroxidase/catalase katG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
4948 Cytochrome c-553 Not Available 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
6021 Adenosine kinase ADK 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
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