DT-Web: DB00370

Identification

Name

Mirtazapine

Accession Number

DB00370 (APRD00685)

Type

small molecule

Description

Mirtazapine is an antidepressant introduced by Organon International in 1996 used for the treatment of moderate to severe depression. Mirtazapine has a tetracyclic chemical structure and is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA). It is the only tetracyclic antidepressant that has been approved by the Food and Drug Administration to treat depression. [Wikipedia]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

265.3529

Groups

approved

Monoisotopic Weight

265.157897623

Pharmacology

Indication

For the treatment of major depressive disorder.

Mechanism of action

Mirtazapine acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative feedback to the presynaptic nerve and causing an increase in NE release. Blockade of heteroreceptors, alpha(2)-receptors contained in serotenergic neurons, enhances the release of 5-HT, increasing the interactions between 5-HT and 5-HT₁ receptors and contributing to the anxiolytic effects of mirtazapine. Mirtazapine also acts as a weak antagonist at 5-HT₁ receptors and as a potent antagonist at 5-HT₂ (particularly subtypes 2A and 2C) and 5-HT₃ receptors. Blockade of these receptors may explain the lower incidence of adverse effects such as anxiety, insomnia, and nausea. Mirtazapine also exhibits significant antagonism at H1-receptors, resulting in sedation. Mirtazapine has no effects on the reuptake of either NE or 5-HT and has only minimal activity at dopaminergic and muscarinic receptors.

Absorption

Rapid and complete, but, due to first-pass metabolism, absolute bioavailability is 50%.

Protein binding

85%

Biotransformation

Mirtazapine is extensively metabolized by demethylation and hydroxylation followed by glucuronide conjugation. Cytochrome P450 2D6 and cytochrome P450 1A2 are involved in formation of the 8-hydroxy metabolite of mirtazapine, and cytochrome P450 3A4 is responsible for the formation of the N-desmethyl and N-oxide metabolites. Several metabolites possess pharmacological activity, but plasma levels are very low.

Route of elimination

This drug is known to be substantially excreted by the kidney (75%).

Toxicity

Symptoms of overdose include disorientation, drowsiness, impaired memory, and tachycardia. LD50 is 600-720mg/kg (oral, mice) and 320-490mg/kg (oral, rat) [PMID: 10333982]

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Clonidine	Possible hypertensive crisis
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Donepezil	Possible antagonism of action
Ethotoin	The hydantoins may reduce mirtazapine plasma concentrations and pharmacological effects
Fluvoxamine	Fluvoxamine may increase the therapeutic and adverse effects of mirtazapine.
Fosphenytoin	The hydantoins may reduce mirtazapine plasma concentrations and pharmacological effects
Galantamine	Possible antagonism of action
Isocarboxazid	Possible severe adverse reaction with this combination
Mephenytoin	The hydantoins may reduce mirtazapine plasma concentrations and pharmacological effects
Phenelzine	Possible severe adverse reaction with this combination
Phenytoin	The hydantoins may reduce mirtazapine plasma concentrations and pharmacological effects
Rasagiline	Possible severe adverse reaction with this combination
Rivastigmine	Possible antagonism of action
Telithromycin	Telithromycin may reduce clearance of Mirtazapine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Mirtazapine if Telithromycin is initiated, discontinued or dose changed.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Mirtazapine. Consider alternate therapy or monitor for therapeutic/adverse effects of Mirtazapine if Terbinafine is initiated, discontinued or dose changed.
Tramadol	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine	The MAO inhibitor, Tranylcypromine, may increase the central neurotoxic effects of the Mirtazapine. These agents should not be administered within 14 days of each other.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Triprolidine	The CNS depressants, Triprolidine and Mirtazapine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of mirtazapine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of mirtazapine if voriconazole is initiated, discontinued or dose changed.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and mirtazapine, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.

Food Interactions

Take without regard to meals. Avoid alcohol.

5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	yes
Actions	antagonist
References	Westenberg HG: Pharmacology of antidepressants: selectivity or multiplicity? J Clin Psychiatry. 1999;60 Suppl 17:4-8; discussion 46-8. - Pubmed Gorman JM: Mirtazapine: clinical overview. J Clin Psychiatry. 1999;60 Suppl 17:9-13; discussion 46-8. - Pubmed Nutt DJ: Care of depressed patients with anxiety symptoms. J Clin Psychiatry. 1999;60 Suppl 17:23-7; discussion 46-8. - Pubmed Laakmann G, Schule C, Baghai T, Waldvogel E: Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy male subjects. Psychoneuroendocrinology. 1999 Oct;24(7):769-84. - Pubmed Waldinger MD, Berendsen HH, Schweitzer DH: Treatment of hot flushes with mirtazapine: four case reports. Maturitas. 2000 Oct 31;36(3):165-8. - Pubmed Anttila SA, Leinonen EV: A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. 2001 Fall;7(3):249-64. - Pubmed
DTHybrid score	0.354
5-hydroxytryptamine 3 receptor
Name	5-hydroxytryptamine 3 receptor
Gene Name	HTR3A
Pharmacological action	yes
Actions	antagonist
References	Westenberg HG: Pharmacology of antidepressants: selectivity or multiplicity? J Clin Psychiatry. 1999;60 Suppl 17:4-8; discussion 46-8. - Pubmed Gorman JM: Mirtazapine: clinical overview. J Clin Psychiatry. 1999;60 Suppl 17:9-13; discussion 46-8. - Pubmed Kast RE, Foley KF: Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. Eur J Cancer Care (Engl). 2007 Jul;16(4):351-4. - Pubmed de Boer T: The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission. Int Clin Psychopharmacol. 1995 Dec;10 Suppl 4:19-23. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Anttila SA, Leinonen EV: A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. 2001 Fall;7(3):249-64. - Pubmed
DTHybrid score	0.2376
Alpha-2A adrenergic receptor
Name	Alpha-2A adrenergic receptor
Gene Name	ADRA2A
Pharmacological action	yes
Actions	antagonist
References	Garcia-Sevilla JA, Ventayol P, Perez V, Rubovszky G, Puigdemont D, Ferrer-Alcon M, Andreoli A, Guimon J, Alvarez E: Regulation of platelet alpha 2A-adrenoceptors, Gi proteins and receptor kinases in major depression: effects of mirtazapine treatment. Neuropsychopharmacology. 2004 Mar;29(3):580-8. - Pubmed Anttila SA, Leinonen EV: A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. 2001 Fall;7(3):249-64. - Pubmed Besson A, Haddjeri N, Blier P, de Montigny C: Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain. Eur Neuropsychopharmacol. 2000 May;10(3):177-88. - Pubmed Schreiber S, Bleich A, Pick CG: Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects--a possible opioid involvement in severe depression? J Mol Neurosci. 2002 Feb-Apr;18(1-2):143-9. - Pubmed Rogoz Z, Wrobel A, Dlaboga D, Maj J, Dziedzicka-Wasylewska M: Effect of repeated treatment with mirtazapine on the central alpha1-adrenergic receptors. J Physiol Pharmacol. 2002 Mar;53(1):105-16. - Pubmed Rogoz Z, Wrobel A, Dlaboga D, Dziedzicka-Wasylewska M: Effect of repeated treatment with mirtazapine on the central dopaminergic D2/D3 receptors. Pol J Pharmacol. 2002 Jul-Aug;54(4):381-9. - Pubmed
DTHybrid score	0.3738
5-hydroxytryptamine 2C receptor
Name	5-hydroxytryptamine 2C receptor
Gene Name	HTR2C
Pharmacological action	unknown
Actions	antagonist
References	Benelli A, Frigeri C, Bertolini A, Genedani S: Influence of mirtazapine on the sexual behavior of male rats. Psychopharmacology (Berl). 2004 Jan;171(3):250-8. Epub 2003 Nov 13. - Pubmed Millan MJ, Gobert A, Rivet JM, Adhumeau-Auclair A, Cussac D, Newman-Tancredi A, Dekeyne A, Nicolas JP, Lejeune F: Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram. Eur J Neurosci. 2000 Mar;12(3):1079-95. - Pubmed Meert TF, Melis W, Aerts N, Clincke G: Antagonism of meta-chlorophenylpiperazine-induced inhibition of exploratory activity in an emergence procedure, the open field test, in rats. Behav Pharmacol. 1997 Aug;8(4):353-63. - Pubmed Millan MJ: Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie. 2005 Sep-Oct;60(5):441-60. - Pubmed Dekeyne A, Iob L, Millan MJ: Following long-term training with citalopram, both mirtazapine and mianserin block its discriminative stimulus properties in rats. Psychopharmacology (Berl). 2001 Jan;153(3):389-92. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.2721
Kappa-type opioid receptor
Name	Kappa-type opioid receptor
Gene Name	OPRK1
Pharmacological action	unknown
Actions	agonist
References	Schreiber S, Rigai T, Katz Y, Pick CG: The antinociceptive effect of mirtazapine in mice is mediated through serotonergic, noradrenergic and opioid mechanisms. Brain Res Bull. 2002 Sep 30;58(6):601-5. - Pubmed
DTHybrid score	0.3732
Histamine H1 receptor
Name	Histamine H1 receptor
Gene Name	HRH1
Pharmacological action	no
Actions	antagonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6244

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Anttila SA, Leinonen EV: A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. 2001 Fall;7(3):249-64. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Stormer E, von Moltke LL, Shader RI, Greenblatt DJ: Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4. Drug Metab Dispos. 2000 Oct;28(10):1168-75. - Pubmed
DTHybrid score	0.712
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor,inducer
References	Anttila SA, Leinonen EV: A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. 2001 Fall;7(3):249-64. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Stormer E, von Moltke LL, Shader RI, Greenblatt DJ: Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4. Drug Metab Dispos. 2000 Oct;28(10):1168-75. - Pubmed
DTHybrid score	0.6543
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Anttila SA, Leinonen EV: A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. 2001 Fall;7(3):249-64. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Stormer E, von Moltke LL, Shader RI, Greenblatt DJ: Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4. Drug Metab Dispos. 2000 Oct;28(10):1168-75. - Pubmed
DTHybrid score	0.4947
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3352

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.3113
847	Mu-type opioid receptor	OPRM1	0.2868
1588	Multidrug resistance protein 1	ABCB1	0.2561
467	Delta-type opioid receptor	OPRD1	0.2473
556	Alpha-1A adrenergic receptor	ADRA1A	0.2247
4118	Cytochrome P450 3A5	CYP3A5	0.223
831	D(2) dopamine receptor	DRD2	0.2087
6030	Cytochrome P450 2B6	CYP2B6	0.1905
23	D(1A) dopamine receptor	DRD1	0.1728
6013	Cytochrome P450 2E1	CYP2E1	0.1706
6107	Cytochrome P450 3A7	CYP3A7	0.1703
320	5-hydroxytryptamine 1A receptor	HTR1A	0.1616
824	Sodium-dependent serotonin transporter	SLC6A4	0.1458
378	Alpha-2C adrenergic receptor	ADRA2C	0.1423
629	Alpha-2B adrenergic receptor	ADRA2B	0.1421
6024	Cytochrome P450 1A1	CYP1A1	0.126
103	Muscarinic acetylcholine receptor M1	CHRM1	0.1229
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.1179
632	Alpha-1B adrenergic receptor	ADRA1B	0.1169
638	D(3) dopamine receptor	DRD3	0.1157
436	5-hydroxytryptamine 2B receptor	HTR2B	0.11
5718	Cytochrome P450 2A6	CYP2A6	0.1087
432	D(4) dopamine receptor	DRD4	0.1048
617	Muscarinic acetylcholine receptor M2	CHRM2	0.1032
587	Serum albumin	ALB	0.0991
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0979
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0975
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0972
713	Sodium-dependent dopamine transporter	SLC6A3	0.0938
20	Prostaglandin G/H synthase 1	PTGS1	0.0903
716	5-hydroxytryptamine 7 receptor	HTR7	0.0845
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0829
163	D(1B) dopamine receptor	DRD5	0.0813
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0807
6145	Solute carrier family 22 member 1	SLC22A1	0.0804
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0743
789	Alpha-1D adrenergic receptor	ADRA1D	0.0704
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0644
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0595
6144	Solute carrier family 22 member 2	SLC22A2	0.0565
6106	Cytochrome P450 2C18	CYP2C18	0.0546
766	Beta-2 adrenergic receptor	ADRB2	0.0523
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0496
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0493
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.047
290	Prostaglandin G/H synthase 2	PTGS2	0.0464
3941	Amine oxidase [flavin-containing] A	MAOA	0.0462
193	Beta-1 adrenergic receptor	ADRB1	0.046
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0451
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.045
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.044
1729	Solute carrier family 22 member 6	SLC22A6	0.0431
94	5-hydroxytryptamine 4 receptor	HTR4	0.0427
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0419
1716	Tripartite motif-containing protein 13	TRIM13	0.0402
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0402
118	Organic cation/carnitine transporter 2	SLC22A5	0.0399
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0395
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0388
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0387
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0384
1898	Cytochrome P450 1B1	CYP1B1	0.0374
3923	Cholinesterase	BCHE	0.0369
174	Sigma 1-type opioid receptor	SIGMAR1	0.0368
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0365
3811	Cytochrome P450 19A1	CYP19A1	0.0362
862	Multidrug resistance-associated protein 1	ABCC1	0.0362
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0337
1262	Corticotropin-lipotropin	POMC	0.0317
136	Estrogen receptor	ESR1	0.0314
131	Synaptic vesicular amine transporter	SLC18A2	0.0303
474	Acetylcholinesterase	ACHE	0.0296
465	Calmodulin	CALM1	0.0293
3939	Amine oxidase [flavin-containing] B	MAOB	0.0278
6147	Solute carrier family 22 member 3	SLC22A3	0.0259
36	Insulin receptor	INSR	0.0258
871	Glucocorticoid receptor	NR3C1	0.0255
124	Histamine H2 receptor	HRH2	0.0254
776	Bile salt export pump	ABCB11	0.0252
833	Organic cation/carnitine transporter 1	SLC22A4	0.0246
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0241
731	HIV-1 protease	HIV-1 protease	0.0236
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0233
2164	Multidrug resistance-associated protein 4	ABCC4	0.0228
1656	CYP2B protein	CYP2B	0.0226
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0226
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0223
6142	Solute carrier family 22 member 8	SLC22A8	0.0212
6182	Cytochrome P450 2J2	CYP2J2	0.0199
1341	Histamine H3 receptor	HRH3	0.0198
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0197
817	DNA topoisomerase 2-alpha	TOP2A	0.0196
571	Melatonin receptor type 1A	MTNR1A	0.0193
362	Melatonin receptor type 1B	MTNR1B	0.0193
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0192
6143	Solute carrier family 22 member 7	SLC22A7	0.0188
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0185
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0184
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.018
5838	Transient receptor potential cation channel subfamily V member 3	TRPV3	0.0176
2162	Transient receptor potential cation channel subfamily M member 8	TRPM8	0.0176
1944	Transient receptor potential cation channel subfamily A member 1	TRPA1	0.0176
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0173
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0172
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0171
891	Dihydropteroate synthase	folP	0.0171
5359	Dihydropteroate synthase	folP	0.0171
7175	Dihydropteroate synthase	sulI	0.0171
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0171
516	Neurotensin receptor type 2	NTSR2	0.0168
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0166
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0165
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0163
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0162
6031	Cytochrome P450 3A43	CYP3A43	0.0161
260	Cytochrome P450 51	ERG11	0.016
761	Cytochrome P450 51	ERG11	0.016
3163	Cytochrome P450 51	cyp51	0.016
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0159
122	P2Y purinoceptor 12	P2RY12	0.0159
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0157
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0156
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0154
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0154
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0153
3810	Catechol O-methyltransferase	COMT	0.0152
468	Cytochrome P450 4A11	CYP4A11	0.015
70	Type-1 angiotensin II receptor	AGTR1	0.0149
319	Opioid receptor, sigma 1	OPRS1	0.0148
477	DNA topoisomerase 4 subunit A	parC	0.0146
886	DNA topoisomerase 4 subunit A	parC	0.0146
6226	DNA topoisomerase 4 subunit A	parC	0.0146
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0145
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0145
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0144
404	DNA gyrase subunit A	gyrA	0.0144
6224	DNA gyrase subunit A	gyrA	0.0144
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0143
1275	Estrogen sulfotransferase	SULT1E1	0.0141
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0139
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0139
4137	Nociceptin receptor	OPRL1	0.0136
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0132
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0131
6020	Aldehyde oxidase	AOX1	0.013
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0129
6432	Transporter	snf	0.0129
1024	Solute carrier family 22 member 11	SLC22A11	0.0129
146	Androgen receptor	AR	0.0128
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0126
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0126
164	Histamine H4 receptor	HRH4	0.0122
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0117
504	Mast/stem cell growth factor receptor	KIT	0.0115
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0112
1517	Beta-3 adrenergic receptor	ADRB3	0.0112
380	Cytochrome P450 17A1	CYP17A1	0.0112
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0111
4120	NADPH--cytochrome P450 reductase	POR	0.0111
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0111
16	Adenosine A1 receptor	ADORA1	0.011
614	Progesterone receptor	PGR	0.011
6102	Arylamine N-acetyltransferase 2	NAT2	0.0109
777	Tumor necrosis factor	TNF	0.0109
6220	Aryl hydrocarbon receptor	AHR	0.0109
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0108
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0108
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0108
811	Translocator protein	TSPO	0.0108
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0106
365	Dihydrofolate reductase	DHFR	0.0105
2381	Dihydrofolate reductase	DFR1	0.0105
2833	Dihydrofolate reductase	Not Available	0.0105
2931	Dihydrofolate reductase	folA	0.0105
3544	Dihydrofolate reductase	folA	0.0105
3682	Dihydrofolate reductase	folA	0.0105
6642	Dihydrofolate reductase	folA	0.0105
6756	Dihydrofolate reductase	dfrA	0.0105
1178	Adenosine A2a receptor	ADORA2A	0.0105
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0104
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0103
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0102
921	Glutamate receptor 2	GRIA2	0.0102
6070	Nischarin	NISCH	0.0099
844	Epidermal growth factor receptor	EGFR	0.0099
4116	Dihydropteroate synthetase	Not Available	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
6148	Multidrug resistance-associated protein 7	ABCC10	0.0096
3426	Glutamine synthetase	glnA	0.0096
3987	Glutamine synthetase	GLUL	0.0096
407	Vascular endothelial growth factor receptor 2	KDR	0.0094
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0093
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0093
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0093
232	Corticosteroid-binding globulin	SERPINA6	0.0093
4604	Liver carboxylesterase 1	CES1	0.0091
6136	Multidrug resistance-associated protein 5	ABCC5	0.0091
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0091
869	Estrogen receptor beta	ESR2	0.0091
6014	Cytochrome P450 2A13	CYP2A13	0.0091
1757	Myeloperoxidase	MPO	0.0091
4203	Histamine N-methyltransferase	HNMT	0.009
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0089
818	50S ribosomal protein L10	rplJ	0.0089
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0088
952	Dipeptidyl peptidase 4	DPP4	0.0088
1618	High affinity nerve growth factor receptor	NTRK1	0.0088
6141	Sodium/bile acid cotransporter	SLC10A1	0.0088
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0087
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0084
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0084
6137	Multidrug resistance-associated protein 6	ABCC6	0.0083
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0083
29	Tubulin beta-1 chain	TUBB1	0.0081
3947	Xanthine dehydrogenase/oxidase	XDH	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
295	Carbonic anhydrase 1	CA1	0.008
904	Glutathione S-transferase P	GSTP1	0.008
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0079
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0079
173	Toll-like receptor 7	TLR7	0.0079
828	Phenylalanine-4-hydroxylase	PAH	0.0078
3109	Phenylalanine-4-hydroxylase	phhA	0.0078
4122	Histone deacetylase 2	HDAC2	0.0078
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0077
1291	cAMP response element-binding protein	CREB1	0.0077
1010	Cytochrome P450 51A1	CYP51A1	0.0077
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0077
26	Vascular endothelial growth factor receptor 3	FLT4	0.0077
161	Tubulin beta chain	TUBB	0.0076
312	Tubulin beta chain	TUB2	0.0076
373	Transthyretin	TTR	0.0076
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0076
923	Glutamate receptor 3	GRIA3	0.0075
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0075
275	Arachidonate 5-lipoxygenase	ALOX5	0.0075
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0075
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0074
1541	Metalloproteinase	mmp20	0.0074
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0074
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0074
32	Vascular endothelial growth factor receptor 1	FLT1	0.0073
592	Carbonic anhydrase 4	CA4	0.0073
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0072
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0072
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0072
756	Sex hormone-binding globulin	SHBG	0.0072
427	Substance-P receptor	TACR1	0.0072
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0071
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0071
4210	Toll-like receptor 4	TLR4	0.0071
49	Endothelin B receptor	EDNRB	0.0069
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0069
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0069
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0069
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0068
1629	Transcription factor AP-1	JUN	0.0068
2112	Toll-like receptor 9	TLR9	0.0068
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0067
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0066
88	Retinoic acid receptor RXR-beta	RXRB	0.0066
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0065
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0065
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0065
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0065
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0065
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0065
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0065
737	Mineralocorticoid receptor	NR3C2	0.0065
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0065
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
1648	Elastin	ELN	0.0063
1050	Bile salt sulfotransferase	SULT2A1	0.0063
133	Dihydropterate synthase	sulI	0.0063
6085	Fatty acid-binding protein, intestinal	FABP2	0.0063
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
814	Ryanodine receptor 1	RYR1	0.0062
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0062
273	Apoptosis regulator Bcl-2	BCL2	0.0061
6097	Protein S100-A2	S100A2	0.006
1810	Protein S100-A1	S100A1	0.006
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.006
5251	Carbonyl reductase [NADPH] 1	CBR1	0.006
24	Thymidylate synthase	TMP1	0.0059
359	Thymidylate synthase	TYMS	0.0059
2626	Thymidylate synthase	thyA	0.0059
2729	Thymidylate synthase	thyA	0.0059
5352	Thymidylate synthase	THYA	0.0059
738	Monocarboxylate transporter 1	SLC16A1	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0058
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0058
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0058
1636	Trace amine-associated receptor 1	TAAR1	0.0058
518	Peroxidase/catalase T	katG	0.0056
284	DNA-directed RNA polymerase beta chain	rpoB	0.0056
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0056
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0056
482	Glycine receptor subunit alpha-1	GLRA1	0.0055
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0055
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0055
6506	Stathmin-4	STMN4	0.0055
357	Carbonic anhydrase 2	CA2	0.0055
856	Vitamin D3 receptor	VDR	0.0054
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0053
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0052
712	Tubulin alpha chain	TUB1	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
1048	Protein S100-A13	S100A13	0.0052
2226	Protein S100-A12	S100A12	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0051
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0051
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.005
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
6044	Serum paraoxonase/lactonase 3	PON3	0.005
2132	Protein S100-B	S100B	0.0049
780	Retinoic acid receptor RXR-gamma	RXRG	0.0049
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0049
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0048
634	Squalene monooxygenase	SQLE	0.0047
7196	Squalene monooxygenase	ERG1	0.0047
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0047
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0047
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
6126	Carbonic anhydrase 7	CA7	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
4237	50S ribosomal protein L22	rplV	0.0046
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0045
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
3086	Plasmepsin-2	Not Available	0.0045
3856	Fibroblast growth factor receptor 3	FGFR3	0.0045
1192	Sulfotransferase 1A1	SULT1A1	0.0045
4311	tRNA	TRDMT1	0.0045
4325	tRNA	trmD	0.0045
4328	tRNA	trmD	0.0045
6043	Putative G-protein coupled receptor 44	GPR44	0.0044
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0044
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
183	Vascular endothelial growth factor A	VEGFA	0.0044
823	Fibroblast growth factor receptor 2	FGFR2	0.0044
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0043
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0043
705	Glutamate receptor 1	GRIA1	0.0043
714	Glutathione reductase, mitochondrial	GSR	0.0042
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0042
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
6146	High affinity copper uptake protein 1	SLC31A1	0.0041
233	Potassium channel subfamily K member 2	KCNK2	0.0041
2449	Tubulin alpha-3 chain	TUBA1A	0.0041
581	Cytochrome P450 2R1	CYP2R1	0.0041
459	Retinoic acid receptor RXR-alpha	RXRA	0.0041
162	Retinoic acid receptor gamma-1	RARG	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.004
3932	Glutathione S-transferase A2	GSTA2	0.004
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
54	Prothrombin	F2	0.004
6138	Multidrug resistance protein 3	ABCB4	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0038
153	Dopamine beta-hydroxylase	DBH	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
3957	Adenosine deaminase	ADA	0.0038
165	FL cytokine receptor	FLT3	0.0038
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0037
239	Coagulation factor X	F10	0.0037
563	Thyroid peroxidase	TPO	0.0036
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0036
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0036
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0036
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0036
558	Solute carrier family 12 member 1	SLC12A1	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
2539	Tubulin alpha-1 chain	TUBA4A	0.0035
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0035
976	Platelet glycoprotein IX	GP9	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0035
4103	Proteasome subunit beta type 2	PSMB2	0.0034
4102	Proteasome subunit beta type 5	PSMB5	0.0034
4101	Proteasome subunit beta type 1	PSMB1	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
1483	Membrane copper amine oxidase	AOC3	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0034
5300	Antigen peptide transporter 1	TAP1	0.0034
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0033
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0033
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0033
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0033
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0033
229	Retinoic acid receptor beta	RARB	0.0033
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0033
730	Retinoic acid receptor alpha	RARA	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0031
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0031
5787	Angiopoietin-1 receptor	TEK	0.0031
1196	Complement decay-accelerating factor	CD55	0.0031
3809	Estrogen-related receptor gamma	ESRRG	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
84	Nuclear receptor 0B1	NR0B1	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
3639	Thymidine phosphorylase	deoA	0.003
3936	Thymidine phosphorylase	TYMP	0.003
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
469	Annexin A1	ANXA1	0.003
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.003
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.003
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.003
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.003
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0029
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0029
1992	Vitamin D-binding protein	GC	0.0029
268	Adenosine A2b receptor	ADORA2B	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1852	Microtubule-associated protein 2	MAP2	0.0028
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0027
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0027
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0027
2808	Chloramphenicol acetyltransferase 3	cat3	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
1630	Integrin beta-2	ITGB2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
33	Cystine/glutamate transporter	SLC7A11	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0027
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0026
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0026
6149	Solute carrier family 22 member 10	SLC22A10	0.0026
6151	Monocarboxylate transporter 10	SLC16A10	0.0026
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
3937	Fatty-acid amide hydrolase	FAAH	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
2417	Chloramphenicol acetyltransferase	cat	0.0025
3278	Chloramphenicol acetyltransferase	cat	0.0025
3808	Dihydropteroate synthase 2	folP2	0.0025
3601	Dihydropteroate synthase 1	folP1	0.0025
3807	Dihydropteroate synthase 1	folP1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
2810	Dr hemagglutinin structural subunit	draA	0.0025
1374	Natriuretic peptides B	NPPB	0.0025
1827	Gap junction alpha-1 protein	GJA1	0.0025
1908	Vascular cell adhesion protein 1	VCAM1	0.0025
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0025
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0024
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4773	Deoxycytidine kinase	DCK	0.0024
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
4226	Uridine phosphorylase 2	UPP2	0.0023
6048	Troponin C, skeletal muscle	TNNC2	0.0023
4192	DNA topoisomerase 2-beta	TOP2B	0.0023
7	Nitric oxide synthase, inducible	NOS2	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0023
1830	5'-nucleotidase	NT5E	0.0023
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0023
5934	Cytochrome P450 26A1	CYP26A1	0.0023
751	Potassium channel subfamily K member 6	KCNK6	0.0023
908	Glutathione S-transferase theta-1	GSTT1	0.0023
3404	Exotoxin A	eta	0.0022
936	Ephrin type-A receptor 2	EPHA2	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
6824	Tyrosine-protein kinase Lyn	LYN	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
4225	Uridine phosphorylase 1	UPP1	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0021
172	Potassium channel subfamily K member 1	KCNK1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
572	Integrin alpha-L	ITGAL	0.0021
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.002
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.002
3868	Calcineurin subunit B isoform 2	PPP3R2	0.002
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.002
594	Thyroxine-binding globulin	SERPINA7	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
413	Amidophosphoribosyltransferase	PPAT	0.002
2515	Amidophosphoribosyltransferase	purF	0.002
3714	Amidophosphoribosyltransferase	purF	0.002
4217	Telomerase reverse transcriptase	TERT	0.002
1820	Beta-nerve growth factor	NGF	0.002
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
5923	Microtubule-associated protein tau	MAPT	0.0019
5924	Microtubule-associated protein 4	MAP4	0.0019
2216	Fibroblast growth factor receptor 4	FGFR4	0.0019
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
760	Fibroblast growth factor 1	FGF1	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
1039	Histone deacetylase 9	HDAC9	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1864	RET proto-oncogene	RET	0.0018
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0018
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0018
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0018
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0018
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0018
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
199	Monocarboxylate transporter 8	SLC16A2	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
719	Retinoic acid receptor responder protein 1	RARRES1	0.0017
770	Retinoic acid-induced protein 3	GPRC5A	0.0017
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0017
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0017
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0017
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0017
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0017
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0017
106	Cannabinoid receptor 2	CNR2	0.0017
251	Alcohol dehydrogenase 1A	ADH1A	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
1243	Cathepsin D	CTSD	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0016
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0016
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0016
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0016
3830	Calreticulin	CALR	0.0016
5798	Mitogen-activated protein kinase 11	MAPK11	0.0016
820	Glycine receptor subunit alpha-2	GLRA2	0.0016
2207	Rhodopsin	RHO	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2320	Thymidine kinase, cytosolic	TK1	0.0015
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
569	Retinal dehydrogenase 2	ALDH1A2	0.0015
267	Plasminogen activator inhibitor 1	SERPINE1	0.0015
896	Glutathione S-transferase Mu 1	GSTM1	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0015
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0015
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0015
1714	Mitogen-activated protein kinase 3	MAPK3	0.0015
6034	Hydroxyindole O-methyltransferase	ASMT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6035	Nuclear receptor ROR-beta	RORB	0.0015
6036	Eosinophil peroxidase	EPX	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
444	Alcohol dehydrogenase 1B	ADH1B	0.0015
489	Monocarboxylate transporter 2	SLC16A7	0.0014
611	Retinal dehydrogenase 1	ALDH1A1	0.0014
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0014
6167	Organic solute transporter subunit beta	OSTB	0.0014
6166	Organic solute transporter subunit alpha	OSTA	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0014
6221	Steroid hormone receptor ERR1	ESRRA	0.0014
6218	Pannexin-1	PANX1	0.0014
6859	Protein S100-A4	S100A4	0.0014
291	Nitric-oxide synthase, endothelial	NOS3	0.0013
2021	Thrombomodulin	THBD	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
3904	Alanine aminotransferase 2	GPT2	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
765	Indoleamine 2,3-dioxygenase	IDO1	0.0013
517	Alcohol dehydrogenase 1C	ADH1C	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0011
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.001
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
283	SEC14-like protein 2	SEC14L2	0.001
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
6163	Copper-transporting ATPase 2	ATP7B	0.001
6165	Copper-transporting ATPase 1	ATP7A	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6459	Glycodelin	PAEP	0.0009
484	Tyrosine-protein kinase ABL2	ABL2	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
65	Matrix metalloproteinase-9	Not Available	0.0009
1792	Tissue-type plasminogen activator	PLAT	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0009
6677	Myelin P2 protein	PMP2	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
2298	Cytochrome P450-cam	camC	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
1867	Major prion protein	PRNP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
3221	Cytochrome c4	cc4	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
822	Aldose reductase	AKR1B1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
125	DNA polymerase beta	POLB	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
1507	Cytochrome c	CYCS	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
76	Nitric-oxide synthase, brain	NOS1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
798	Osteocalcin	BGLAP	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4916	Cyanoglobin	glbN	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4943	Cytochrome c6	petJ	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
5000	HemO	hemO	0.0005
4984	Neuroglobin	NGB	0.0005
4909	CooA protein	cooA	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4910	Cytoglobin	CYGB	0.0005
4961	Hemophore HasA	hasA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4972	P450cin	cinA	0.0005
4952	Catalase/peroxidase	katA	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
2240	Cell division protein kinase 2	CDK2	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
358	Cystathionine beta-synthase	CBS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00370 - Mirtazapine

Targets

Enzymes

Predictions