DT-Web: DB01075

Identification

Name

Diphenhydramine

Accession Number

DB01075 (APRD00587, DB06975)

Type

small molecule

Description

A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

255.3547

Groups

approved

Monoisotopic Weight

255.162314299

Pharmacology

Indication

For the treatment of symptoms associated with Vertigo/Meniere's disease, nausea and vomiting, motion sickness and insect bite.

Mechanism of action

Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.

Absorption

Quickly absorbed with maximum activity occurring in approximately one hour.

Protein binding

98 to 99%

Biotransformation

Hepatic and renal

Route of elimination

Little, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.

Toxicity

LD₅₀=500 mg/kg (orally in rats). Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atomoxetine	Diphenhydramine, a moderate CYP2D6 inhibitor, may increase the therapeutic and adverse effects of atomoxetine by decreasing its metabolism.
Donepezil	Possible antagonism of action
Galantamine	Possible antagonism of action
Mesoridazine	Increased risk of cardiotoxicity and arrhythmias
Rivastigmine	Possible antagonism of action
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Diphenhydramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Tamoxifen	Diphenhydramine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin	Diphenhydramine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Diphenhydramine is initiated, discontinued, or dose changed.
Thioridazine	Increased risk of cardiotoxicity and arrhythmias
Tramadol	Diphenhydramine may decrease the effect of Tramadol by decreasing active metabolite production.
Trimethobenzamide	Trimethobenzamide and Diphenhydramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine	Triprolidine and Diphenhydramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium	Trospium and Diphenhydramine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.

Food Interactions

Take with food.
Avoid alcohol.

Histamine H1 receptor
Name	Histamine H1 receptor
Gene Name	HRH1
Pharmacological action	yes
Actions	antagonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Piao H, Nagai S, Tsurumaki T, Niki T, Higuchi H: Potentiation by neuropeptide Y of histamine H1 receptor-mediated contraction in rat blood vessels. Vascul Pharmacol. 2007 Apr;46(4):260-70. Epub 2006 Oct 27. - Pubmed Kesiova M, Alexandrova A, Yordanova N, Kirkova M, Todorov S: Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues. Pharmacol Rep. 2006 Mar-Apr;58(2):221-8. - Pubmed Hasala H, Moilanen E, Janka-Junttila M, Giembycz MA, Kankaanranta H: First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis. Allergy Asthma Proc. 2007 Jan-Feb;28(1):79-86. - Pubmed Wang Z, Woolverton WL: Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects. Eur J Pharmacol. 2007 Feb 28;557(2-3):159-60. Epub 2006 Dec 1. - Pubmed Ishikawa T, Takechi K, Rahman A, Ago J, Matsumoto N, Murakami A, Kamei C: Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats. Biol Pharm Bull. 2007 Mar;30(3):477-80. - Pubmed Havas TE, Cole P, Parker L, Oprysk D, Ayiomamitis A: The effects of combined H1 and H2 histamine antagonists on alterations in nasal airflow resistance induced by topical histamine provocation. J Allergy Clin Immunol. 1986 Nov;78(5 Pt 1):856-60. - Pubmed
DTHybrid score	0.5691

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Hamelin BA, Bouayad A, Drolet B, Gravel A, Turgeon J: In vitro characterization of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug Metab Dispos. 1998 Jun;26(6):536-9. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5885
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5021
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5648
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.495
Cytochrome P450 2C18
Name	Cytochrome P450 2C18
Gene Name	CYP2C18
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.2244
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.3558
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.4752

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
DTHybrid score	0.2688
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
DTHybrid score	0.3296
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed
DTHybrid score	0.276

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.5191
4924	Cytochrome P450 2C8	CYP2C8	0.295
1588	Multidrug resistance protein 1	ABCB1	0.2704
4118	Cytochrome P450 3A5	CYP3A5	0.2091
6013	Cytochrome P450 2E1	CYP2E1	0.1819
290	Prostaglandin G/H synthase 2	PTGS2	0.1817
6107	Cytochrome P450 3A7	CYP3A7	0.1638
6024	Cytochrome P450 1A1	CYP1A1	0.1463
5718	Cytochrome P450 2A6	CYP2A6	0.1454
587	Serum albumin	ALB	0.1259
1729	Solute carrier family 22 member 6	SLC22A6	0.1185
833	Organic cation/carnitine transporter 1	SLC22A4	0.1108
6147	Solute carrier family 22 member 3	SLC22A3	0.1037
824	Sodium-dependent serotonin transporter	SLC6A4	0.0927
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0912
556	Alpha-1A adrenergic receptor	ADRA1A	0.0883
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0841
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0836
6142	Solute carrier family 22 member 8	SLC22A8	0.0831
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0827
831	D(2) dopamine receptor	DRD2	0.0782
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.077
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0733
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0715
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0695
713	Sodium-dependent dopamine transporter	SLC6A3	0.0688
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0679
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0666
318	Alpha-2A adrenergic receptor	ADRA2A	0.0664
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0655
862	Multidrug resistance-associated protein 1	ABCC1	0.0626
766	Beta-2 adrenergic receptor	ADRB2	0.0625
23	D(1A) dopamine receptor	DRD1	0.0568
193	Beta-1 adrenergic receptor	ADRB1	0.0555
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0543
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0539
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0515
632	Alpha-1B adrenergic receptor	ADRA1B	0.0508
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0493
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.049
274	Muscarinic acetylcholine receptor M5	CHRM5	0.048
1898	Cytochrome P450 1B1	CYP1B1	0.047
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0467
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0453
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0441
629	Alpha-2B adrenergic receptor	ADRA2B	0.0425
1024	Solute carrier family 22 member 11	SLC22A11	0.0419
3923	Cholinesterase	BCHE	0.0418
6143	Solute carrier family 22 member 7	SLC22A7	0.0413
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0411
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.041
378	Alpha-2C adrenergic receptor	ADRA2C	0.0403
776	Bile salt export pump	ABCB11	0.0399
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0384
3811	Cytochrome P450 19A1	CYP19A1	0.0381
3941	Amine oxidase [flavin-containing] A	MAOA	0.038
789	Alpha-1D adrenergic receptor	ADRA1D	0.0375
2164	Multidrug resistance-associated protein 4	ABCC4	0.0372
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0369
817	DNA topoisomerase 2-alpha	TOP2A	0.0366
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0362
477	DNA topoisomerase 4 subunit A	parC	0.0361
886	DNA topoisomerase 4 subunit A	parC	0.0361
6226	DNA topoisomerase 4 subunit A	parC	0.0361
404	DNA gyrase subunit A	gyrA	0.0356
6224	DNA gyrase subunit A	gyrA	0.0356
124	Histamine H2 receptor	HRH2	0.0354
3939	Amine oxidase [flavin-containing] B	MAOB	0.0351
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0344
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0342
465	Calmodulin	CALM1	0.034
1757	Myeloperoxidase	MPO	0.0335
468	Cytochrome P450 4A11	CYP4A11	0.0333
275	Arachidonate 5-lipoxygenase	ALOX5	0.0324
638	D(3) dopamine receptor	DRD3	0.0322
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0312
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0311
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0309
847	Mu-type opioid receptor	OPRM1	0.03
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0299
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0295
731	HIV-1 protease	HIV-1 protease	0.0294
432	D(4) dopamine receptor	DRD4	0.0288
1341	Histamine H3 receptor	HRH3	0.0287
474	Acetylcholinesterase	ACHE	0.0278
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0277
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0272
467	Delta-type opioid receptor	OPRD1	0.0267
696	Kappa-type opioid receptor	OPRK1	0.0263
36	Insulin receptor	INSR	0.0258
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0257
738	Monocarboxylate transporter 1	SLC16A1	0.0251
136	Estrogen receptor	ESR1	0.0249
6010	Thiamine transporter 1	SLC19A2	0.0248
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0246
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0246
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0242
6137	Multidrug resistance-associated protein 6	ABCC6	0.0233
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0232
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0229
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0229
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0228
260	Cytochrome P450 51	ERG11	0.0223
761	Cytochrome P450 51	ERG11	0.0223
3163	Cytochrome P450 51	cyp51	0.0223
175	Thiamin pyrophosphokinase 1	TPK1	0.0222
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0221
131	Synaptic vesicular amine transporter	SLC18A2	0.0206
7	Nitric oxide synthase, inducible	NOS2	0.0204
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0204
380	Cytochrome P450 17A1	CYP17A1	0.0199
122	P2Y purinoceptor 12	P2RY12	0.0198
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0195
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0195
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0194
6148	Multidrug resistance-associated protein 7	ABCC10	0.0194
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0194
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.019
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.019
163	D(1B) dopamine receptor	DRD5	0.019
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0188
1656	CYP2B protein	CYP2B	0.0188
891	Dihydropteroate synthase	folP	0.0188
5359	Dihydropteroate synthase	folP	0.0188
7175	Dihydropteroate synthase	sulI	0.0188
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0187
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0184
6031	Cytochrome P450 3A43	CYP3A43	0.0181
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0181
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0178
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0174
159	Penicillin-binding protein 2B	penA	0.0171
6121	Penicillin-binding protein 2B	penA	0.0171
716	5-hydroxytryptamine 7 receptor	HTR7	0.017
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0169
4203	Histamine N-methyltransferase	HNMT	0.0169
516	Neurotensin receptor type 2	NTSR2	0.0168
6136	Multidrug resistance-associated protein 5	ABCC5	0.0165
146	Androgen receptor	AR	0.0164
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0163
6432	Transporter	snf	0.0163
6164	POU domain, class 5, transcription factor 1	POU5F1	0.016
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.016
6182	Cytochrome P450 2J2	CYP2J2	0.016
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0159
70	Type-1 angiotensin II receptor	AGTR1	0.0159
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0158
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0158
6014	Cytochrome P450 2A13	CYP2A13	0.0157
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0155
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0154
164	Histamine H4 receptor	HRH4	0.015
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0149
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0149
6102	Arylamine N-acetyltransferase 2	NAT2	0.0148
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0147
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0145
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0145
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0145
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0145
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0145
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0145
85	Growth hormone receptor	GHR	0.0144
373	Transthyretin	TTR	0.0143
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0143
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0143
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0143
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0143
1275	Estrogen sulfotransferase	SULT1E1	0.0142
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0142
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0141
3947	Xanthine dehydrogenase/oxidase	XDH	0.0141
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.014
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0139
4773	Deoxycytidine kinase	DCK	0.0138
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0137
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0137
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0137
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0136
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0135
6220	Aryl hydrocarbon receptor	AHR	0.0134
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0132
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0132
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0132
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0131
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0131
504	Mast/stem cell growth factor receptor	KIT	0.0131
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.013
844	Epidermal growth factor receptor	EGFR	0.0129
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0128
624	Guanidinoacetate N-methyltransferase	GAMT	0.0128
2472	Voltage-gated potassium channel	kcsA	0.0128
6366	Voltage-gated potassium channel	kcsA	0.0128
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0126
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
811	Translocator protein	TSPO	0.0125
6141	Sodium/bile acid cotransporter	SLC10A1	0.0125
828	Phenylalanine-4-hydroxylase	PAH	0.0124
3109	Phenylalanine-4-hydroxylase	phhA	0.0124
756	Sex hormone-binding globulin	SHBG	0.0121
633	Penicillin-binding proteins 1A/1B	pbpA	0.012
1507	Cytochrome c	CYCS	0.012
4120	NADPH--cytochrome P450 reductase	POR	0.0119
777	Tumor necrosis factor	TNF	0.0117
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0117
1517	Beta-3 adrenergic receptor	ADRB3	0.0115
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0115
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0114
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0114
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0114
4604	Liver carboxylesterase 1	CES1	0.0113
6070	Nischarin	NISCH	0.0113
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0111
571	Melatonin receptor type 1A	MTNR1A	0.011
362	Melatonin receptor type 1B	MTNR1B	0.011
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0109
869	Estrogen receptor beta	ESR2	0.0109
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0108
6085	Fatty acid-binding protein, intestinal	FABP2	0.0107
427	Substance-P receptor	TACR1	0.0105
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0105
1636	Trace amine-associated receptor 1	TAAR1	0.0104
6146	High affinity copper uptake protein 1	SLC31A1	0.0104
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0104
174	Sigma 1-type opioid receptor	SIGMAR1	0.0104
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0104
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0103
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0103
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0103
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0102
94	5-hydroxytryptamine 4 receptor	HTR4	0.0102
482	Glycine receptor subunit alpha-1	GLRA1	0.0101
976	Platelet glycoprotein IX	GP9	0.0101
958	Insulin-like growth factor 1 receptor	IGF1R	0.0101
5126	Arginase	rocF	0.01
3810	Catechol O-methyltransferase	COMT	0.01
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
1618	High affinity nerve growth factor receptor	NTRK1	0.0098
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
558	Solute carrier family 12 member 1	SLC12A1	0.0095
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0094
921	Glutamate receptor 2	GRIA2	0.0094
1830	5'-nucleotidase	NT5E	0.0094
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0092
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0092
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0091
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0091
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.009
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.009
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0089
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0088
161	Tubulin beta chain	TUBB	0.0088
312	Tubulin beta chain	TUB2	0.0088
3808	Dihydropteroate synthase 2	folP2	0.0087
3601	Dihydropteroate synthase 1	folP1	0.0087
3807	Dihydropteroate synthase 1	folP1	0.0087
6174	50S ribosomal protein L32	rpmF	0.0087
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0087
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0087
1010	Cytochrome P450 51A1	CYP51A1	0.0086
1629	Transcription factor AP-1	JUN	0.0086
3312	Fatty acid-binding protein, brain	FABP7	0.0086
694	Matrix protein 2	M	0.0086
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0085
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0085
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0085
153	Dopamine beta-hydroxylase	DBH	0.0084
16	Adenosine A1 receptor	ADORA1	0.0084
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0084
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0084
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0083
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0083
1	Peptidoglycan synthetase ftsI	ftsI	0.0083
4155	Peptidoglycan synthetase ftsI	ftsI	0.0083
737	Mineralocorticoid receptor	NR3C2	0.0082
527	Prostacyclin receptor	PTGIR	0.0082
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0081
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0081
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0081
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0081
2300	Lysozyme	E	0.0081
3633	Lysozyme	R	0.0081
5597	Lysozyme	17	0.0081
1178	Adenosine A2a receptor	ADORA2A	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
3611	Cytidine deaminase	cdd	0.008
3707	Cytidine deaminase	cdd	0.008
4211	Cytidine deaminase	CDA	0.008
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
1039	Histone deacetylase 9	HDAC9	0.0078
867	Penicillin-binding protein 3	pbpC	0.0077
6119	Penicillin-binding protein 3	pbp3	0.0077
7154	Penicillin-binding protein 3	pbp3	0.0077
7157	Penicillin-binding protein 3	LMHCC_2184	0.0077
7162	Penicillin-binding protein 3	pbpB	0.0077
7172	Penicillin-binding protein 3	pbp3	0.0077
407	Vascular endothelial growth factor receptor 2	KDR	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
904	Glutathione S-transferase P	GSTP1	0.0076
26	Vascular endothelial growth factor receptor 3	FLT4	0.0076
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0076
6149	Solute carrier family 22 member 10	SLC22A10	0.0076
818	50S ribosomal protein L10	rplJ	0.0076
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0075
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0075
908	Glutathione S-transferase theta-1	GSTT1	0.0075
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0075
125	DNA polymerase beta	POLB	0.0074
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0074
338	DNA polymerase	UL30	0.0073
379	DNA polymerase	UL54	0.0073
697	DNA polymerase	ORF28	0.0073
2482	DNA polymerase	43	0.0073
4104	DNA polymerase	BALF5	0.0073
32	Vascular endothelial growth factor receptor 1	FLT1	0.0073
3426	Glutamine synthetase	glnA	0.0073
3987	Glutamine synthetase	GLUL	0.0073
645	Penicillin-binding protein 1A	mrcA	0.0073
5805	Penicillin-binding protein 1A	ponA	0.0073
6185	Penicillin-binding protein 1A	mrcA	0.0073
6799	Penicillin-binding protein 1A	pbpA	0.0073
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0072
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0071
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0071
365	Dihydrofolate reductase	DHFR	0.007
2381	Dihydrofolate reductase	DFR1	0.007
2833	Dihydrofolate reductase	Not Available	0.007
2931	Dihydrofolate reductase	folA	0.007
3544	Dihydrofolate reductase	folA	0.007
3682	Dihydrofolate reductase	folA	0.007
6642	Dihydrofolate reductase	folA	0.007
6756	Dihydrofolate reductase	dfrA	0.007
6171	Solute carrier family 28 member 3	SLC28A3	0.007
183	Vascular endothelial growth factor A	VEGFA	0.007
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.007
49	Endothelin B receptor	EDNRB	0.007
823	Fibroblast growth factor receptor 2	FGFR2	0.007
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.007
751	Potassium channel subfamily K member 6	KCNK6	0.0068
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0068
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0068
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0068
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0067
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0067
1648	Elastin	ELN	0.0067
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
357	Carbonic anhydrase 2	CA2	0.0067
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0067
1864	RET proto-oncogene	RET	0.0067
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0066
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0066
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0066
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0066
578	Endothelin-1 receptor	EDNRA	0.0066
6165	Copper-transporting ATPase 1	ATP7A	0.0066
6163	Copper-transporting ATPase 2	ATP7B	0.0066
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0066
295	Carbonic anhydrase 1	CA1	0.0066
130	Prostacyclin synthase	PTGIS	0.0065
592	Carbonic anhydrase 4	CA4	0.0065
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0065
84	Nuclear receptor 0B1	NR0B1	0.0064
860	Nicotinamide N-methyltransferase	NNMT	0.0064
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0064
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
699	Nicotinic acid receptor 1	GPR109A	0.0064
928	Nicotinic acid receptor 2	GPR109B	0.0064
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0064
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0063
780	Retinoic acid receptor RXR-gamma	RXRG	0.0063
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
173	Toll-like receptor 7	TLR7	0.0063
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0063
133	Dihydropterate synthase	sulI	0.0063
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0063
172	Potassium channel subfamily K member 1	KCNK1	0.0063
565	Extracellular calcium-sensing receptor	CASR	0.0062
614	Progesterone receptor	PGR	0.0062
4116	Dihydropteroate synthetase	Not Available	0.0062
634	Squalene monooxygenase	SQLE	0.0062
7196	Squalene monooxygenase	ERG1	0.0062
563	Thyroid peroxidase	TPO	0.0062
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0061
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0061
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0061
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0061
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.006
332	Beta-lactamase	blaZ	0.0059
2478	Beta-lactamase	ampC	0.0059
2613	Beta-lactamase	ampC	0.0059
2635	Beta-lactamase	ampC	0.0059
2700	Beta-lactamase	penP	0.0059
5445	Beta-lactamase	blaB	0.0059
6019	Beta-lactamase	SHV-7	0.0059
6701	Beta-lactamase	cphA	0.0059
489	Monocarboxylate transporter 2	SLC16A7	0.0059
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
723	Cytosolic phospholipase A2	PLA2G4A	0.0059
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0058
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0058
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0058
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0058
871	Glucocorticoid receptor	NR3C1	0.0058
6067	Penicillin binding protein 2a	mecA	0.0058
705	Glutamate receptor 1	GRIA1	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0058
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
6218	Pannexin-1	PANX1	0.0058
4122	Histone deacetylase 2	HDAC2	0.0057
88	Retinoic acid receptor RXR-beta	RXRB	0.0057
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0057
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0057
33	Cystine/glutamate transporter	SLC7A11	0.0057
788	Creatine kinase M-type	CKM	0.0057
703	NADPH azoreductase	azr	0.0056
5682	Ribonuclease pancreatic	RNASE1	0.0056
518	Peroxidase/catalase T	katG	0.0056
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0056
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0056
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0056
3926	Choline transporter-like protein 2	SLC44A2	0.0056
861	Choline kinase alpha	CHKA	0.0056
1686	Choline transporter-like protein 1	SLC44A1	0.0056
769	High-affinity choline transporter 1	SLC5A7	0.0056
3927	Choline transporter-like protein 3	SLC44A3	0.0056
3925	Choline transporter-like protein 4	SLC44A4	0.0056
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0056
700	Choline dehydrogenase, mitochondrial	CHDH	0.0056
576	Choline O-acetyltransferase	CHAT	0.0056
3922	Phospholipase D2	PLD2	0.0056
3924	Phospholipase D1	PLD1	0.0056
273	Apoptosis regulator Bcl-2	BCL2	0.0056
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0055
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0055
1770	Phospholipase C	PLCL1	0.0055
2841	Phospholipase C	plc	0.0055
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0055
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0054
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0054
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0053
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0053
896	Glutathione S-transferase Mu 1	GSTM1	0.0053
850	Vasopressin V1b receptor	AVPR1B	0.0053
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0052
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0052
719	Retinoic acid receptor responder protein 1	RARRES1	0.0052
6043	Putative G-protein coupled receptor 44	GPR44	0.0052
770	Retinoic acid-induced protein 3	GPRC5A	0.0052
1192	Sulfotransferase 1A1	SULT1A1	0.0051
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0051
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0051
5626	Nucleoside diphosphate kinase B	NME2	0.0051
3937	Fatty-acid amide hydrolase	FAAH	0.005
6097	Protein S100-A2	S100A2	0.005
1810	Protein S100-A1	S100A1	0.005
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
459	Retinoic acid receptor RXR-alpha	RXRA	0.0049
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0049
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0049
106	Cannabinoid receptor 2	CNR2	0.0048
6126	Carbonic anhydrase 7	CA7	0.0047
185	Vasopressin V1a receptor	AVPR1A	0.0046
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
322	Vasopressin V2 receptor	AVPR2	0.0046
6044	Serum paraoxonase/lactonase 3	PON3	0.0046
291	Nitric-oxide synthase, endothelial	NOS3	0.0045
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0045
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
4103	Proteasome subunit beta type 2	PSMB2	0.0045
4102	Proteasome subunit beta type 5	PSMB5	0.0045
4101	Proteasome subunit beta type 1	PSMB1	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
569	Retinal dehydrogenase 2	ALDH1A2	0.0045
6167	Organic solute transporter subunit beta	OSTB	0.0044
6166	Organic solute transporter subunit alpha	OSTA	0.0044
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0044
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0044
2112	Toll-like receptor 9	TLR9	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
1048	Protein S100-A13	S100A13	0.0043
2226	Protein S100-A12	S100A12	0.0043
714	Glutathione reductase, mitochondrial	GSR	0.0042
6020	Aldehyde oxidase	AOX1	0.0042
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0042
611	Retinal dehydrogenase 1	ALDH1A1	0.0042
2449	Tubulin alpha-3 chain	TUBA1A	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0041
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0041
162	Retinoic acid receptor gamma-1	RARG	0.0041
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0041
6103	Arylamine N-acetyltransferase 1	NAT1	0.0041
5294	Nucleoside diphosphate kinase A	NME1	0.0041
123	Diamine acetyltransferase 1	SAT1	0.004
2132	Protein S100-B	S100B	0.004
4192	DNA topoisomerase 2-beta	TOP2B	0.004
500	Monocarboxylate transporter 4	SLC16A3	0.004
581	Cytochrome P450 2R1	CYP2R1	0.004
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0039
4217	Telomerase reverse transcriptase	TERT	0.0039
6212	Tubulin gamma-1 chain	TUBG1	0.0039
6210	Tubulin delta chain	TUBD1	0.0039
6211	Tubulin epsilon chain	TUBE1	0.0039
6168	Solute carrier family 22 member 16	SLC22A16	0.0038
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
702	UMP-CMP kinase	CMPK1	0.0037
1992	Vitamin D-binding protein	GC	0.0037
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0037
319	Opioid receptor, sigma 1	OPRS1	0.0037
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0036
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0036
1374	Natriuretic peptides B	NPPB	0.0036
1827	Gap junction alpha-1 protein	GJA1	0.0036
1908	Vascular cell adhesion protein 1	VCAM1	0.0036
4228	Keratin, type II cytoskeletal 7	KRT7	0.0036
4311	tRNA	TRDMT1	0.0036
4325	tRNA	trmD	0.0036
4328	tRNA	trmD	0.0036
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
1074	Urokinase-type plasminogen activator	PLAU	0.0036
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0036
1050	Bile salt sulfotransferase	SULT2A1	0.0035
1630	Integrin beta-2	ITGB2	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0035
6033	High affinity interleukin-8 receptor A	CXCR1	0.0034
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0034
712	Tubulin alpha chain	TUB1	0.0034
952	Dipeptidyl peptidase 4	DPP4	0.0034
284	DNA-directed RNA polymerase beta chain	rpoB	0.0033
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0033
6506	Stathmin-4	STMN4	0.0033
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0033
277	Purine nucleoside phosphorylase	PNP	0.0033
2870	Purine nucleoside phosphorylase	punA	0.0033
2945	Purine nucleoside phosphorylase	punA	0.0033
4659	Purine nucleoside phosphorylase	TM_1596	0.0033
4825	Purine nucleoside phosphorylase	TTHA1435	0.0033
499	Arginine decarboxylase	ADC	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
251	Alcohol dehydrogenase 1A	ADH1A	0.0032
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0032
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0032
1714	Mitogen-activated protein kinase 3	MAPK3	0.0032
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
24	Thymidylate synthase	TMP1	0.0031
359	Thymidylate synthase	TYMS	0.0031
2626	Thymidylate synthase	thyA	0.0031
2729	Thymidylate synthase	thyA	0.0031
5352	Thymidylate synthase	THYA	0.0031
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0031
577	Argininosuccinate lyase	ASL	0.0031
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0031
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0031
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0031
834	Arginase-2, mitochondrial	ARG2	0.0031
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.003
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.003
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
820	Glycine receptor subunit alpha-2	GLRA2	0.003
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.003
3957	Adenosine deaminase	ADA	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
150	Cationic amino acid transporter 3	SLC7A3	0.003
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.003
58	Cationic amino acid transporter 4	SLC7A4	0.003
2320	Thymidine kinase, cytosolic	TK1	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.003
2207	Rhodopsin	RHO	0.0029
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0029
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0029
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0029
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0029
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0029
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0029
54	Prothrombin	F2	0.0029
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0029
6138	Multidrug resistance protein 3	ABCB4	0.0029
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0029
165	FL cytokine receptor	FLT3	0.0029
444	Alcohol dehydrogenase 1B	ADH1B	0.0029
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0028
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0028
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0028
5934	Cytochrome P450 26A1	CYP26A1	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
740	Argininosuccinate synthase	ASS1	0.0028
865	Argininosuccinate synthase	ASS1	0.0028
2680	Argininosuccinate synthase	argG	0.0028
3194	Argininosuccinate synthase	argG	0.0028
856	Vitamin D3 receptor	VDR	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
3932	Glutathione S-transferase A2	GSTA2	0.0028
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0027
2236	Casein kinase II subunit alpha	CSNK2A1	0.0027
551	Carnitine O-acetyltransferase	CRAT	0.0027
6500	Phospholipase A2	PLA2G1B	0.0026
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
29	Tubulin beta-1 chain	TUBB1	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0026
1262	Corticotropin-lipotropin	POMC	0.0026
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0026
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0025
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
3830	Calreticulin	CALR	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
1541	Metalloproteinase	mmp20	0.0025
517	Alcohol dehydrogenase 1C	ADH1C	0.0025
2021	Thrombomodulin	THBD	0.0025
239	Coagulation factor X	F10	0.0024
759	Free fatty acid receptor 1	FFAR1	0.0024
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
3639	Thymidine phosphorylase	deoA	0.0024
3936	Thymidine phosphorylase	TYMP	0.0024
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
6151	Monocarboxylate transporter 10	SLC16A10	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
1196	Complement decay-accelerating factor	CD55	0.0023
65	Matrix metalloproteinase-9	Not Available	0.0023
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0023
936	Ephrin type-A receptor 2	EPHA2	0.0023
822	Aldose reductase	AKR1B1	0.0023
6131	Carbonic anhydrase 14	CA14	0.0022
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
2539	Tubulin alpha-1 chain	TUBA4A	0.0022
3809	Estrogen-related receptor gamma	ESRRG	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
5798	Mitogen-activated protein kinase 11	MAPK11	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
267	Plasminogen activator inhibitor 1	SERPINE1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1053	BC269730_2	FADS1	0.0021
1395	Sodium/calcium exchanger 1	SLC8A1	0.0021
5300	Antigen peptide transporter 1	TAP1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
5787	Angiopoietin-1 receptor	TEK	0.0021
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.002
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.002
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
2808	Chloramphenicol acetyltransferase 3	cat3	0.002
1820	Beta-nerve growth factor	NGF	0.002
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.002
814	Ryanodine receptor 1	RYR1	0.002
1243	Cathepsin D	CTSD	0.0019
1650	Heme carrier protein 1	SLC46A1	0.0019
3856	Fibroblast growth factor receptor 3	FGFR3	0.0019
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0019
4948	Cytochrome c-553	Not Available	0.0019
4923	Cytochrome c3	DvMF_2499	0.0019
4945	Cytochrome c3	Not Available	0.0019
4949	Cytochrome c3	DVU_3171	0.0019
4968	Cytochrome c3	cytc3	0.0019
4997	Cytochrome c3	SO_2727	0.0019
5219	Cytochrome c3	cyd	0.0019
4902	Nine-heme cytochrome c	Ddes_2038	0.0019
3189	High-molecular-weight cytochrome c	hmcA	0.0019
6221	Steroid hormone receptor ERR1	ESRRA	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
2417	Chloramphenicol acetyltransferase	cat	0.0018
3278	Chloramphenicol acetyltransferase	cat	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
6042	Prostaglandin reductase 2	PTGR2	0.0018
469	Annexin A1	ANXA1	0.0018
1253	Interferon gamma	IFNG	0.0018
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0018
2810	Dr hemagglutinin structural subunit	draA	0.0018
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0018
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0018
1268	Neuropeptide S receptor	NPSR1	0.0018
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0018
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
4954	Soluble cytochrome b558	Not Available	0.0018
4934	Cytochrome c-551	nirM	0.0018
5218	Cytochrome c-551	nirM	0.0018
4925	Cytochrome c-type protein SHP	shp	0.0018
4905	Cytochrome c2	Not Available	0.0018
4939	Cytochrome c2	cycA	0.0018
4964	Cytochrome c2	cycA	0.0018
4979	Cytochrome c2	cycA	0.0018
6673	Cytochrome c2	cycA	0.0018
4915	Cytochrome c-550	psbV	0.0018
4959	Cytochrome c-550	psbV	0.0018
5216	Cytochrome c-550	psbV	0.0018
4947	Bacterial hemoglobin	vhb	0.0018
4943	Cytochrome c6	petJ	0.0018
4975	Cytochrome c-556	RPA3973	0.0018
4984	Neuroglobin	NGB	0.0018
4916	Cyanoglobin	glbN	0.0018
4998	Hemoglobin-like protein yjbI	yjbI	0.0018
4994	Hemoglobin-like protein HbO	glbO	0.0018
3116	Bacterioferritin	bfr	0.0018
4906	Bacterioferritin	bfr	0.0018
4965	Bacterioferritin	bfr	0.0018
4907	Cytochrome c-L	moxG	0.0018
6865	Cytochrome c-L	moxG	0.0018
4936	Cytochrome c2 iso-2	Not Available	0.0018
4909	CooA protein	cooA	0.0018
4942	Diheme cytochrome c napB	napB	0.0018
644	Heme oxygenase 2	HMOX2	0.0018
4982	Heme oxygenase 2	pbsA2	0.0018
4981	Iron-starvation protein PigA	pigA	0.0018
4910	Cytoglobin	CYGB	0.0018
4961	Hemophore HasA	hasA	0.0018
5000	HemO	hemO	0.0018
4976	Apocytochrome f	petA	0.0018
6407	Apocytochrome f	petA	0.0018
4971	Nonaheme cytochrome c	hmcA	0.0018
4935	Cytochrome c-554	cycA1	0.0018
4904	Cytochrome c family protein	GSU1996	0.0018
4989	Cytochrome c551 peroxidase	ccp	0.0018
5222	Cytochrome c551 peroxidase	ccpA	0.0018
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0018
4764	Cytochrome P450 165C4	CYP165C4	0.0018
4999	Cytochrome P450 165B3	CYP165B3	0.0018
4960	Putative cytochrome P450-family protein	SCO7417	0.0018
4931	Cytochrome P450 167A1	CYP167A1	0.0018
4937	Cytochrome oxidase subunit II	rcoxA	0.0018
4903	Methyl-accepting chemotaxis protein	Tar4	0.0018
4972	P450cin	cinA	0.0018
4993	Hydroxylamine oxidoreductase	hao1	0.0018
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0018
4922	Cytochrome c, putative	SO_4144	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0018
4952	Catalase/peroxidase	katA	0.0018
3093	Catalase HPII	katE	0.0018
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0018
268	Adenosine A2b receptor	ADORA2B	0.0017
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0017
1792	Tissue-type plasminogen activator	PLAT	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
6073	Potassium channel subfamily K member 9	KCNK9	0.0017
6072	Potassium channel subfamily K member 3	KCNK3	0.0017
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0016
572	Integrin alpha-L	ITGAL	0.0016
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0016
4386	Hemoglobin-like protein HbN	glbN	0.0016
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0016
76	Nitric-oxide synthase, brain	NOS1	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
4785	Ig gamma-1 chain C region	IGHG1	0.0015
3221	Cytochrome c4	cc4	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
3086	Plasmepsin-2	Not Available	0.0014
1313	Lactoylglutathione lyase	GLO1	0.0014
4226	Uridine phosphorylase 2	UPP2	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0014
2232	Interleukin-5	IL5	0.0014
1593	Mucin-2	MUC2	0.0014
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0013
4920	Peroxidase/catalase	katG	0.0013
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0013
3404	Exotoxin A	eta	0.0013
2119	Cytochrome b5	CYB5A	0.0013
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0013
4990	PpcA	ppcA	0.0013
4988	Sulfite oxidase, mitochondrial	SUOX	0.0013
3375	Acidic cytochrome c3	Not Available	0.0013
4037	Hypothetical protein	GPX1	0.0013
4297	Hypothetical protein	SP_1951	0.0013
4521	Hypothetical protein	BC_2969	0.0013
4540	Hypothetical protein	TM_1070	0.0013
4555	Hypothetical protein	MT1739	0.0013
4569	Hypothetical protein	mshD	0.0013
4578	Hypothetical protein	PA3270	0.0013
4747	Hypothetical protein	PA3967	0.0013
5177	Hypothetical protein	TM_0096	0.0013
5194	Hypothetical protein	PA1204	0.0013
5240	Hypothetical protein	Rv2991	0.0013
5370	Hypothetical protein	TM_1158	0.0013
5710	Hypothetical protein	Tb927.5.1360	0.0013
2915	Sensor protein fixL	fixL	0.0013
4944	Sensor protein fixL	fixL	0.0013
3570	Cytochrome P450 152A1	cypC	0.0013
4385	Cytochrome c'	Not Available	0.0013
4967	Cytochrome c'	cycA	0.0013
5038	Cytochrome c'	Not Available	0.0013
5223	Cytochrome c'	cycP	0.0013
4992	Cytochrome c peroxidase	Not Available	0.0013
4289	Cytochrome P450	TT_P0059	0.0013
6262	Cytochrome P450	staP	0.0013
4813	Heme oxygenase	hmuO	0.0013
5769	Heme oxygenase	Not Available	0.0013
2230	Catalase	CAT	0.0013
3249	Catalase	katA	0.0013
3625	Catalase	katA	0.0013
4539	Catalase	katA	0.0013
4941	Catalase	katB	0.0013
4225	Uridine phosphorylase 1	UPP1	0.0013
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0013
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0013
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0013
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0012
232	Corticosteroid-binding globulin	SERPINA6	0.0012
413	Amidophosphoribosyltransferase	PPAT	0.0012
2515	Amidophosphoribosyltransferase	purF	0.0012
3714	Amidophosphoribosyltransferase	purF	0.0012
3587	Gastrotropin	FABP6	0.0012
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0012
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0012
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0012
473	L-lactate dehydrogenase A chain	LDHA	0.0011
6048	Troponin C, skeletal muscle	TNNC2	0.0011
3670	Soluble cytochrome b562 precursor	cybC	0.0011
3411	Cytochrome P450 121	cyp121	0.0011
3291	Cytochrome c-552	cycA	0.0011
4927	Cytochrome c-552	nrfA	0.0011
4938	Cytochrome c-552	cycA	0.0011
4953	Cytochrome c-552	nrfA	0.0011
5217	Cytochrome c-552	cycM	0.0011
2617	Nitric oxide synthase oxygenase	nos	0.0011
2701	Nitric oxide synthase oxygenase	nos	0.0011
3102	Flavohemoprotein	hmp	0.0011
4969	Flavohemoprotein	hmp	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0011
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0011
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0011
2290	ADP-ribosyl cyclase 2	BST1	0.001
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.001
4237	50S ribosomal protein L22	rplV	0.001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
144	Hemoglobin subunit alpha	HBA1	0.001
1353	DNA topoisomerase 1	TOP1	0.001
3552	DNA topoisomerase 1	topA	0.001
3913	Glutamic acid decarboxylase	GAD65	0.001
4608	Putative cytochrome P450	SCO1207	0.001
4963	Putative cytochrome P450	SCO2884	0.001
6254	Putative cytochrome P450	SCO6998	0.001
760	Fibroblast growth factor 1	FGF1	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
358	Cystathionine beta-synthase	CBS	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
1483	Membrane copper amine oxidase	AOC3	0.0009
693	Hemoglobin subunit beta	HBB	0.0009
1184	Interferon beta	IFNB1	0.0008
6268	Hydroxyacid oxidase 1	HAO1	0.0008
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0008
735	Alanine aminotransferase 1	GPT	0.0008
3904	Alanine aminotransferase 2	GPT2	0.0008
244	Angiotensin-converting enzyme	ACE	0.0008
810	Heme oxygenase 1	HMOX1	0.0008
3391	Heme oxygenase 1	pbsA1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
2298	Cytochrome P450-cam	camC	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2430	Chondroitinase B	cslB	0.0005
5924	Microtubule-associated protein 4	MAP4	0.0005
5923	Microtubule-associated protein tau	MAPT	0.0005
798	Osteocalcin	BGLAP	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
1852	Microtubule-associated protein 2	MAP2	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
6133	Sodium channel subunit beta-2	SCN2B	0.0005
6134	Sodium channel subunit beta-3	SCN3B	0.0005
6129	Carbonic anhydrase-related protein 11	CA11	0.0005
6132	Sodium channel subunit beta-1	SCN1B	0.0005
6135	Sodium channel subunit beta-4	SCN4B	0.0005
6127	Carbonic anhydrase-related protein	CA8	0.0005
6128	Carbonic anhydrase-related protein 10	CA10	0.0005
369	Coagulation factor VII	F7	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
6824	Tyrosine-protein kinase Lyn	LYN	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0004
6130	Carbonic anhydrase 13	CA13	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
6122	Carbonic anhydrase 3	CA3	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
3007	Carbonic anhydrase 12	CA12	0.0003
4205	Carbonic anhydrase 9	CA9	0.0003
1439	Lactotransferrin	LTF	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01075 - Diphenhydramine

Targets

Enzymes

Transporters

Predictions