DT-Web

DB00934 - Maprotiline


Identification
Name Maprotiline
Accession Number DB00934 (APRD00747)
Type small molecule
Description Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 277.4033
Groups approved
Monoisotopic Weight 277.183049741
Pharmacology
Indication For treatment of depression, including the depressed phase of bipolar depression, psychotic depression, and involutional melancholia, and may also be helpful in treating certain patients suffering severe depressive neurosis.
Mechanism of action Maprotiline exerts its antidepressant action by inhibition of presynaptic uptake of catecholamines, thereby increasing their concentration at the synaptic clefts of the brain. In single doses, the effect of maprotiline on the EEG revealed a rise in the alpha-wave density, a reduction of the alpha-wave frequency and an increase in the alpha-wave amplitude. However, as with other tricyclic antidepressants, maprotiline lowers the convulsive threshold. Maprotiline acts as an antagonist at central presynaptic α2-adrenergic inhibitory autoreceptors and hetero-receptors, an action that is postulated to result in an increase in central noradrenergic and serotonergic activity. Maprotiline is also a moderate peripheral α1 adrenergic antagonist, which may explain the occasional orthostatic hypotension reported in association with its use. Maprotiline also inhibits the amine transporter, delaying the reuptake of noradrenaline and norepinephrine. Lastly, maprotiline is a strong inhibitor of the histamine H1 receptor, which explains its sedative actions.
Absorption Slowly, but completely absorbed from the GI tract following oral administration.
Protein binding 88%
Biotransformation Hepatic. Maprotiline is metabolized by N-demethylation, deamination, aliphatic and aromatic hydroxylations and by formation of aromatic methoxy derivatives. It is slowly metabolized primarily to desmethylmaprotiline, a pharmacologically active metabolite. Desmethylmaprotiline may undergo further metabolism to maprotiline-N-oxide.
Route of elimination Approximately 60% of a single orally administered dose is excreted in urine as conjugated metabolites within 21 days; 30% is eliminated in feces.
Toxicity LD50=~900 mg/kg (Orally in rats); LD50=90 mg/kg (Orally in women); Signs of overdose include motor unrest, muscular twitching and rigidity, tremor, ataxia, convulsions, hyperpyrexia, vertigo, mydriasis, vomiting, cyanosis, hypotension, shock, tachycardia, cardiac arrhythmias, impaired cardiac conduction, respiratory depression, and disturbances of consciousness up to deep coma.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Propranolol Propranolol increases the serum levels of cisapride
Rivastigmine Possible antagonism of action
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Maprotiline, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Terbinafine Terbinafine may reduce the metabolism and clearance of Maprotiline. Consider alternate therapy or monitor for therapeutic/adverse effects of Maprotiline if Terbinafine is initiated, discontinued or dose changed.
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine Maprotiline may increase the adverse effects of the MAO inhibitor, Tranylcypromine. These agents should not be administered within 14 days of each other.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimethobenzamide Trimethobenzamide and Maprotiline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome. Additive QTc-prolongation may also occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine Triprolidine and Maprotiline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Maprotiline, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolmitriptan Use of two serotonin modulators, such as zolmitriptan and maprotiline, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Take without regard to meals. Limit caffeine intake.

Targets


Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action yes
Actions inhibitor
References
  • Saba W, Valette H, Schollhorn-Peyronneau MA, Coulon C, Ottaviani M, Chalon S, Dolle F, Emond P, Halldin C, Helfenbein J, Madelmont JC, Deloye JB, Guilloteau D, Bottlaender M: [11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET. Synapse. 2007 Jan;61(1):17-23. - Pubmed
  • Arai S, Morita K, Kitayama S, Kumagai K, Kumagai M, Kihira K, Dohi T: Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics. Brain Res. 2003 Feb 21;964(1):83-90. - Pubmed
  • Cloonan SM, Drozgowska A, Fayne D, Williams DC: The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters. Leuk Lymphoma. 2010 Mar;51(3):523-39. - Pubmed
  • Dronjak S, Spasojevic N, Gavrilovic L, Varagic V: Effects of noradrenaline and serotonin reuptake inhibitors on pituitary-adrenocortical and sympatho-adrenomedullar system of adult rats. Neuro Endocrinol Lett. 2007 Oct;28(5):614-20. - Pubmed
  • Mochizucki D: Serotonin and noradrenaline reuptake inhibitors in animal models of pain. Hum Psychopharmacol. 2004 Oct;19 Suppl 1:S15-9. - Pubmed
DTHybrid score 0.4668
Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action no
Actions antagonist
References
  • Noguchi S, Inukai T, Kuno T, Tanaka C: The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking. Physiol Behav. 1992 Jun;51(6):1123-7. - Pubmed
  • Cavero I, Lefevre-Borg F, Roach AG: Effects of mianserin, desipramine and maprotiline on blood pressure responses evoked by acetylcholine, histamine and 5-hydroxytryptamine in rats. Br J Pharmacol. 1981 Sep;74(1):143-8. - Pubmed
  • Kanba S, Richelson E: Histamine H1 receptors in human brain labelled with [3H]doxepin. Brain Res. 1984 Jun 18;304(1):1-7. - Pubmed
DTHybrid score 0.715
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action no
Actions antagonist
References
  • El-Fakahany E, Richelson E: Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain. Br J Pharmacol. 1983 Jan;78(1):97-102. - Pubmed
  • Golds PR, Przyslo FR, Strange PG: The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors. Br J Pharmacol. 1980 Mar;68(3):541-9. - Pubmed
  • Doggrell SA, Vincent L: The postsynaptic effects of antidepressant drugs in the rat anococcygeus muscle. J Pharm Pharmacol. 1981 Nov;33(11):720-4. - Pubmed
DTHybrid score 0.9661
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action no
Actions antagonist
References
  • El-Fakahany E, Richelson E: Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain. Br J Pharmacol. 1983 Jan;78(1):97-102. - Pubmed
  • Golds PR, Przyslo FR, Strange PG: The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors. Br J Pharmacol. 1980 Mar;68(3):541-9. - Pubmed
  • Doggrell SA, Vincent L: The postsynaptic effects of antidepressant drugs in the rat anococcygeus muscle. J Pharm Pharmacol. 1981 Nov;33(11):720-4. - Pubmed
DTHybrid score 0.8247
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action no
Actions antagonist
References
  • El-Fakahany E, Richelson E: Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain. Br J Pharmacol. 1983 Jan;78(1):97-102. - Pubmed
  • Golds PR, Przyslo FR, Strange PG: The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors. Br J Pharmacol. 1980 Mar;68(3):541-9. - Pubmed
  • Doggrell SA, Vincent L: The postsynaptic effects of antidepressant drugs in the rat anococcygeus muscle. J Pharm Pharmacol. 1981 Nov;33(11):720-4. - Pubmed
DTHybrid score 0.8251
Muscarinic acetylcholine receptor M4
Name Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Pharmacological action no
Actions antagonist
References
  • El-Fakahany E, Richelson E: Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain. Br J Pharmacol. 1983 Jan;78(1):97-102. - Pubmed
  • Golds PR, Przyslo FR, Strange PG: The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors. Br J Pharmacol. 1980 Mar;68(3):541-9. - Pubmed
  • Doggrell SA, Vincent L: The postsynaptic effects of antidepressant drugs in the rat anococcygeus muscle. J Pharm Pharmacol. 1981 Nov;33(11):720-4. - Pubmed
DTHybrid score 0.5997
Muscarinic acetylcholine receptor M5
Name Muscarinic acetylcholine receptor M5
Gene Name CHRM5
Pharmacological action no
Actions antagonist
References
  • El-Fakahany E, Richelson E: Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain. Br J Pharmacol. 1983 Jan;78(1):97-102. - Pubmed
  • Golds PR, Przyslo FR, Strange PG: The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors. Br J Pharmacol. 1980 Mar;68(3):541-9. - Pubmed
  • Doggrell SA, Vincent L: The postsynaptic effects of antidepressant drugs in the rat anococcygeus muscle. J Pharm Pharmacol. 1981 Nov;33(11):720-4. - Pubmed
DTHybrid score 0.501
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action no
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4717

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Brachtendorf L, Jetter A, Beckurts KT, Holscher AH, Fuhr U: Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacol Toxicol. 2002 Mar;90(3):144-9. - Pubmed
DTHybrid score 0.633
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4072

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
DTHybrid score 0.4507

Carriers


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.4507

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.4864
824 Sodium-dependent serotonin transporter SLC6A4 0.24
4757 Cytochrome P450 2C9 CYP2C9 0.2376
6016 Cytochrome P450 2C19 CYP2C19 0.2329
502 5-hydroxytryptamine 2A receptor HTR2A 0.215
632 Alpha-1B adrenergic receptor ADRA1B 0.1888
318 Alpha-2A adrenergic receptor ADRA2A 0.1797
713 Sodium-dependent dopamine transporter SLC6A3 0.1754
831 D(2) dopamine receptor DRD2 0.1695
4118 Cytochrome P450 3A5 CYP3A5 0.1584
4924 Cytochrome P450 2C8 CYP2C8 0.1537
6030 Cytochrome P450 2B6 CYP2B6 0.1533
789 Alpha-1D adrenergic receptor ADRA1D 0.145
590 5-hydroxytryptamine 2C receptor HTR2C 0.1376
6013 Cytochrome P450 2E1 CYP2E1 0.1376
23 D(1A) dopamine receptor DRD1 0.1313
587 Serum albumin ALB 0.1159
6107 Cytochrome P450 3A7 CYP3A7 0.1138
3923 Cholinesterase BCHE 0.1123
320 5-hydroxytryptamine 1A receptor HTR1A 0.1108
6024 Cytochrome P450 1A1 CYP1A1 0.105
629 Alpha-2B adrenergic receptor ADRA2B 0.0867
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0832
6145 Solute carrier family 22 member 1 SLC22A1 0.0815
378 Alpha-2C adrenergic receptor ADRA2C 0.0789
432 D(4) dopamine receptor DRD4 0.0788
193 Beta-1 adrenergic receptor ADRB1 0.0759
766 Beta-2 adrenergic receptor ADRB2 0.0745
638 D(3) dopamine receptor DRD3 0.0717
6144 Solute carrier family 22 member 2 SLC22A2 0.0714
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0699
5718 Cytochrome P450 2A6 CYP2A6 0.0678
118 Organic cation/carnitine transporter 2 SLC22A5 0.0563
131 Synaptic vesicular amine transporter SLC18A2 0.0552
220 Sodium channel protein type 5 subunit alpha SCN5A 0.055
3941 Amine oxidase [flavin-containing] A MAOA 0.0544
885 5-hydroxytryptamine 1B receptor HTR1B 0.0539
725 5-hydroxytryptamine 1D receptor HTR1D 0.0522
341 5-hydroxytryptamine 3 receptor HTR3A 0.0519
833 Organic cation/carnitine transporter 1 SLC22A4 0.0511
436 5-hydroxytryptamine 2B receptor HTR2B 0.051
465 Calmodulin CALM1 0.0481
716 5-hydroxytryptamine 7 receptor HTR7 0.0472
163 D(1B) dopamine receptor DRD5 0.046
1256 5-hydroxytryptamine 6 receptor HTR6 0.046
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0456
528 5-hydroxytryptamine 1E receptor HTR1E 0.0405
6106 Cytochrome P450 2C18 CYP2C18 0.0396
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0382
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0382
20 Prostaglandin G/H synthase 1 PTGS1 0.0378
6147 Solute carrier family 22 member 3 SLC22A3 0.0374
862 Multidrug resistance-associated protein 1 ABCC1 0.0373
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0372
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.037
124 Histamine H2 receptor HRH2 0.0368
3939 Amine oxidase [flavin-containing] B MAOB 0.0363
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0335
2129 Sucrase-isomaltase, intestinal SI 0.0331
696 Kappa-type opioid receptor OPRK1 0.0302
1656 CYP2B protein CYP2B 0.0301
6432 Transporter snf 0.0291
847 Mu-type opioid receptor OPRM1 0.0271
1898 Cytochrome P450 1B1 CYP1B1 0.0269
467 Delta-type opioid receptor OPRD1 0.0269
474 Acetylcholinesterase ACHE 0.0264
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0262
36 Insulin receptor INSR 0.0258
1729 Solute carrier family 22 member 6 SLC22A6 0.0256
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0244
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0236
1517 Beta-3 adrenergic receptor ADRB3 0.023
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0223
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0219
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0219
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0216
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0215
6182 Cytochrome P450 2J2 CYP2J2 0.0214
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0207
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0204
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.02
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0196
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0195
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0195
817 DNA topoisomerase 2-alpha TOP2A 0.0193
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0191
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.019
844 Epidermal growth factor receptor EGFR 0.0187
1341 Histamine H3 receptor HRH3 0.0184
776 Bile salt export pump ABCB11 0.0184
290 Prostaglandin G/H synthase 2 PTGS2 0.0179
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0179
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0173
3811 Cytochrome P450 19A1 CYP19A1 0.0169
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0169
516 Neurotensin receptor type 2 NTSR2 0.0168
1360 Sphingomyelin phosphodiesterase SMPD1 0.0167
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0165
477 DNA topoisomerase 4 subunit A parC 0.0163
886 DNA topoisomerase 4 subunit A parC 0.0163
6226 DNA topoisomerase 4 subunit A parC 0.0163
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0162
404 DNA gyrase subunit A gyrA 0.016
6224 DNA gyrase subunit A gyrA 0.016
1636 Trace amine-associated receptor 1 TAAR1 0.0159
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0155
380 Cytochrome P450 17A1 CYP17A1 0.0154
1618 High affinity nerve growth factor receptor NTRK1 0.0151
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.015
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0147
731 HIV-1 protease HIV-1 protease 0.0142
2164 Multidrug resistance-associated protein 4 ABCC4 0.0141
1757 Myeloperoxidase MPO 0.0138
871 Glucocorticoid receptor NR3C1 0.0138
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0135
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0134
723 Cytosolic phospholipase A2 PLA2G4A 0.0134
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.013
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0127
136 Estrogen receptor ESR1 0.0125
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0124
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0124
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0123
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0122
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0118
6142 Solute carrier family 22 member 8 SLC22A8 0.0117
6143 Solute carrier family 22 member 7 SLC22A7 0.0113
164 Histamine H4 receptor HRH4 0.0112
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0111
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0111
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0105
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0104
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0101
828 Phenylalanine-4-hydroxylase PAH 0.0101
3109 Phenylalanine-4-hydroxylase phhA 0.0101
1275 Estrogen sulfotransferase SULT1E1 0.01
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0098
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
3947 Xanthine dehydrogenase/oxidase XDH 0.0096
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0096
94 5-hydroxytryptamine 4 receptor HTR4 0.0095
504 Mast/stem cell growth factor receptor KIT 0.0092
4120 NADPH--cytochrome P450 reductase POR 0.0092
1178 Adenosine A2a receptor ADORA2A 0.0085
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0085
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0084
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0084
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0083
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0082
777 Tumor necrosis factor TNF 0.008
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.008
16 Adenosine A1 receptor ADORA1 0.008
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0079
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0079
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0078
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0078
6141 Sodium/bile acid cotransporter SLC10A1 0.0078
4604 Liver carboxylesterase 1 CES1 0.0078
1050 Bile salt sulfotransferase SULT2A1 0.0076
6148 Multidrug resistance-associated protein 7 ABCC10 0.0076
228 Beta platelet-derived growth factor receptor PDGFRB 0.0075
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0074
260 Cytochrome P450 51 ERG11 0.0074
761 Cytochrome P450 51 ERG11 0.0074
3163 Cytochrome P450 51 cyp51 0.0074
183 Vascular endothelial growth factor A VEGFA 0.0074
1192 Sulfotransferase 1A1 SULT1A1 0.0073
244 Angiotensin-converting enzyme ACE 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
6138 Multidrug resistance protein 3 ABCB4 0.0071
468 Cytochrome P450 4A11 CYP4A11 0.007
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0067
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0065
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0065
6220 Aryl hydrocarbon receptor AHR 0.0065
869 Estrogen receptor beta ESR2 0.0065
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0065
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0065
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0064
161 Tubulin beta chain TUBB 0.0063
312 Tubulin beta chain TUB2 0.0063
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0063
173 Toll-like receptor 7 TLR7 0.0063
565 Extracellular calcium-sensing receptor CASR 0.0062
122 P2Y purinoceptor 12 P2RY12 0.0062
6137 Multidrug resistance-associated protein 6 ABCC6 0.0061
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0061
26 Vascular endothelial growth factor receptor 3 FLT4 0.006
6859 Protein S100-A4 S100A4 0.006
5787 Angiopoietin-1 receptor TEK 0.006
768 FK506-binding protein 1A FKBP1A 0.006
482 Glycine receptor subunit alpha-1 GLRA1 0.006
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0059
6031 Cytochrome P450 3A43 CYP3A43 0.0058
511 5-hydroxytryptamine 1F receptor HTR1F 0.0058
738 Monocarboxylate transporter 1 SLC16A1 0.0058
32 Vascular endothelial growth factor receptor 1 FLT1 0.0058
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0057
952 Dipeptidyl peptidase 4 DPP4 0.0057
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0057
818 50S ribosomal protein L10 rplJ 0.0057
2112 Toll-like receptor 9 TLR9 0.0055
614 Progesterone receptor PGR 0.0055
2449 Tubulin alpha-3 chain TUBA1A 0.0054
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0054
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0054
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0054
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0054
407 Vascular endothelial growth factor receptor 2 KDR 0.0053
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0053
904 Glutathione S-transferase P GSTP1 0.0053
373 Transthyretin TTR 0.0053
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0053
2981 Phospholipase A2, membrane associated PLA2G2A 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
70 Type-1 angiotensin II receptor AGTR1 0.0051
6097 Protein S100-A2 S100A2 0.005
1810 Protein S100-A1 S100A1 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
146 Androgen receptor AR 0.0049
4203 Histamine N-methyltransferase HNMT 0.0049
1024 Solute carrier family 22 member 11 SLC22A11 0.0049
6014 Cytochrome P450 2A13 CYP2A13 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0048
273 Apoptosis regulator Bcl-2 BCL2 0.0048
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0047
6136 Multidrug resistance-associated protein 5 ABCC5 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
4122 Histone deacetylase 2 HDAC2 0.0046
2499 Tubulin beta-2C chain TUBB2C 0.0046
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0044
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0044
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0043
756 Sex hormone-binding globulin SHBG 0.0043
1048 Protein S100-A13 S100A13 0.0043
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0043
2226 Protein S100-A12 S100A12 0.0043
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
6151 Monocarboxylate transporter 10 SLC16A10 0.0042
1629 Transcription factor AP-1 JUN 0.0041
365 Dihydrofolate reductase DHFR 0.0041
2381 Dihydrofolate reductase DFR1 0.0041
2833 Dihydrofolate reductase Not Available 0.0041
2931 Dihydrofolate reductase folA 0.0041
3544 Dihydrofolate reductase folA 0.0041
3682 Dihydrofolate reductase folA 0.0041
6642 Dihydrofolate reductase folA 0.0041
6756 Dihydrofolate reductase dfrA 0.0041
1010 Cytochrome P450 51A1 CYP51A1 0.0041
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0041
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0041
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0041
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0041
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0041
4238 50S ribosomal protein L4 rplD 0.004
5578 50S ribosomal protein L4 rplD 0.004
6173 50S ribosomal protein L4 rplD 0.004
6219 50S ribosomal protein L4 rplD 0.004
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.004
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.004
2132 Protein S100-B S100B 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0039
1374 Natriuretic peptides B NPPB 0.0039
1827 Gap junction alpha-1 protein GJA1 0.0039
1908 Vascular cell adhesion protein 1 VCAM1 0.0039
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0039
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0038
6044 Serum paraoxonase/lactonase 3 PON3 0.0038
1864 RET proto-oncogene RET 0.0038
117 Sterol O-acyltransferase 1 SOAT1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0038
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0038
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0038
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0038
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0038
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0038
737 Mineralocorticoid receptor NR3C2 0.0038
4237 50S ribosomal protein L22 rplV 0.0037
4103 Proteasome subunit beta type 2 PSMB2 0.0037
4102 Proteasome subunit beta type 5 PSMB5 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
4101 Proteasome subunit beta type 1 PSMB1 0.0037
3426 Glutamine synthetase glnA 0.0037
3987 Glutamine synthetase GLUL 0.0037
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0037
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0037
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0036
3957 Adenosine deaminase ADA 0.0036
4228 Keratin, type II cytoskeletal 7 KRT7 0.0036
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
712 Tubulin alpha chain TUB1 0.0034
751 Potassium channel subfamily K member 6 KCNK6 0.0034
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0033
6506 Stathmin-4 STMN4 0.0033
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0033
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0032
3856 Fibroblast growth factor receptor 3 FGFR3 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
172 Potassium channel subfamily K member 1 KCNK1 0.0031
319 Opioid receptor, sigma 1 OPRS1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.003
6102 Arylamine N-acetyltransferase 2 NAT2 0.003
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
239 Coagulation factor X F10 0.0029
683 Potassium transporter GK0582 0.0029
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0028
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0028
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0027
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0027
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
165 FL cytokine receptor FLT3 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0027
4311 tRNA TRDMT1 0.0027
4325 tRNA trmD 0.0027
4328 tRNA trmD 0.0027
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
427 Substance-P receptor TACR1 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0026
174 Sigma 1-type opioid receptor SIGMAR1 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0026
29 Tubulin beta-1 chain TUBB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
24 Thymidylate synthase TMP1 0.0025
359 Thymidylate synthase TYMS 0.0025
2626 Thymidylate synthase thyA 0.0025
2729 Thymidylate synthase thyA 0.0025
5352 Thymidylate synthase THYA 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0024
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
6070 Nischarin NISCH 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
233 Potassium channel subfamily K member 2 KCNK2 0.0023
232 Corticosteroid-binding globulin SERPINA6 0.0023
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0023
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0022
6020 Aldehyde oxidase AOX1 0.0022
284 DNA-directed RNA polymerase beta chain rpoB 0.0022
5773 DNA-directed RNA polymerase beta chain rpoB 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
823 Fibroblast growth factor receptor 2 FGFR2 0.0022
6085 Fatty acid-binding protein, intestinal FABP2 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
6146 High affinity copper uptake protein 1 SLC31A1 0.0022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
518 Peroxidase/catalase T katG 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
33 Cystine/glutamate transporter SLC7A11 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
6167 Organic solute transporter subunit beta OSTB 0.0021
6166 Organic solute transporter subunit alpha OSTA 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0021
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0021
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0021
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0021
976 Platelet glycoprotein IX GP9 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.002
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.002
4192 DNA topoisomerase 2-beta TOP2B 0.002
144 Hemoglobin subunit alpha HBA1 0.002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.002
563 Thyroid peroxidase TPO 0.002
1820 Beta-nerve growth factor NGF 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
814 Ryanodine receptor 1 RYR1 0.0019
275 Arachidonate 5-lipoxygenase ALOX5 0.0019
4773 Deoxycytidine kinase DCK 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0019
634 Squalene monooxygenase SQLE 0.0019
7196 Squalene monooxygenase ERG1 0.0019
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
3810 Catechol O-methyltransferase COMT 0.0019
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0019
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
543 Penicillin-binding protein 1B mrcB 0.0018
6186 Penicillin-binding protein 1B ponB 0.0018
6822 Penicillin-binding protein 1b pbp1b 0.0018
6844 Penicillin-binding protein 1b pbp1b 0.0018
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
645 Penicillin-binding protein 1A mrcA 0.0018
5805 Penicillin-binding protein 1A ponA 0.0018
6185 Penicillin-binding protein 1A mrcA 0.0018
6799 Penicillin-binding protein 1A pbpA 0.0018
159 Penicillin-binding protein 2B penA 0.0018
6121 Penicillin-binding protein 2B penA 0.0018
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0018
908 Glutathione S-transferase theta-1 GSTT1 0.0018
1714 Mitogen-activated protein kinase 3 MAPK3 0.0018
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
811 Translocator protein TSPO 0.0018
229 Retinoic acid receptor beta RARB 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
921 Glutamate receptor 2 GRIA2 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
1648 Elastin ELN 0.0017
1262 Corticotropin-lipotropin POMC 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
3932 Glutathione S-transferase A2 GSTA2 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
1830 5'-nucleotidase NT5E 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0016
7 Nitric oxide synthase, inducible NOS2 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
6211 Tubulin epsilon chain TUBE1 0.0016
6212 Tubulin gamma-1 chain TUBG1 0.0016
6210 Tubulin delta chain TUBD1 0.0016
1243 Cathepsin D CTSD 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
295 Carbonic anhydrase 1 CA1 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
936 Ephrin type-A receptor 2 EPHA2 0.0015
162 Retinoic acid receptor gamma-1 RARG 0.0015
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
6043 Putative G-protein coupled receptor 44 GPR44 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
537 ATP synthase delta chain, mitochondrial ATP5D 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
469 Annexin A1 ANXA1 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
3086 Plasmepsin-2 Not Available 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0014
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0014
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0014
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0014
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0014
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
484 Tyrosine-protein kinase ABL2 ABL2 0.0014
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
2091 Endoplasmin HSP90B1 0.0014
5934 Cytochrome P450 26A1 CYP26A1 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
3404 Exotoxin A eta 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
1630 Integrin beta-2 ITGB2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0012
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
705 Glutamate receptor 1 GRIA1 0.0012
694 Matrix protein 2 M 0.0012
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
3917 Methylenetetrahydrofolate reductase MTHFR 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
54 Prothrombin F2 0.0011
291 Nitric-oxide synthase, endothelial NOS3 0.0011
6048 Troponin C, skeletal muscle TNNC2 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
6459 Glycodelin PAEP 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
572 Integrin alpha-L ITGAL 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
153 Dopamine beta-hydroxylase DBH 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.0009
6165 Copper-transporting ATPase 1 ATP7A 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
3937 Fatty-acid amide hydrolase FAAH 0.0008
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0008
3830 Calreticulin CALR 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
2207 Rhodopsin RHO 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
896 Glutathione S-transferase Mu 1 GSTM1 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
84 Nuclear receptor 0B1 NR0B1 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
517 Alcohol dehydrogenase 1C ADH1C 0.0007
822 Aldose reductase AKR1B1 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
6168 Solute carrier family 22 member 16 SLC22A16 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1992 Vitamin D-binding protein GC 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
592 Carbonic anhydrase 4 CA4 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
2021 Thrombomodulin THBD 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
798 Osteocalcin BGLAP 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
856 Vitamin D3 receptor VDR 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
357 Carbonic anhydrase 2 CA2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
6218 Pannexin-1 PANX1 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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