DT-Web

DB04868 - Nilotinib


Identification
Name Nilotinib
Accession Number DB04868
Type small molecule
Description Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). In June 2006, a Phase I clinical trial found nilotinib has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib (Gleevec®), another tyrosine kinase inhibitor currently used as a first-line treatment. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 529.5158
Groups approved
Monoisotopic Weight 529.183792976
Pharmacology
Indication For the potential treatment of various leukemias, including chronic myeloid leukemia (CML).
Mechanism of action Chronic myelogenous leukaemia (CML) is caused by the BCR-ABL oncogene. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. Nilotinib fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib, over-riding resistance caused by mutations. The ability of AMN107 to inhibit TEL-platelet-derived growth factor receptor-beta (TEL-PDGFRbeta), which causes chronic myelomonocytic leukaemia, and FIP1-like-1-PDGFRalpha, which causes hypereosinophilic syndrome, suggests potential use of AMN107 for myeloproliferative diseases characterised by these kinase fusions (Stover et al, 2005; Weisberg et al, 2005). AMN107 also inhibits the c-Kit receptor kinase, including the D816V-mutated variant of KIT, at pharmacologically achievable concentrations, supporting potential utility in the treatment of mastocytosis, and gastrointestinal stromal tumours (Weisberg et al, 2005; von Bubnoff et al, 2005; Gleixner et al, 2006).
Absorption Orally available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Bendamustine P-glycoprotein (MDR-1) efflux transporter increases bendamustine levels.
Conivaptan CYP3A4 Inhibitors (Strong) may increase the serum concentration of Nilotinib. Nilotinib prescribing information recommends avoiding concurrent use of nilotinib with strong inhibitors of CYP3A4.
Etravirine Nilotinib, when used concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to avoid concurrent therapy.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Tacrolimus May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Tamoxifen Nilotinib may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin Nilotinib, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Nilotinib is initiated, discontinued, or dose changed.
Telithromycin Telithromycin may reduce clearance of Nilotinib. Concomitant therapy should be avoided.
Thiothixene May cause additive QTc-prolonging effects. Concomitant therapy should be avoided.
Topotecan The p-glycoprotein inhibitor, Nilotinib, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Toremifene May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Tramadol Nilotinib may decrease the effect of Tramadol by decreasing active metabolite production.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Tretinoin The moderate CYP2C8 inhibitor, Nilotinib, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Nilotinib is initiated, discontinued to dose changed.
Trimipramine May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Voriconazole Voriconazole may increase the serum concentration of nilotinib by inhibiting its metabolism by CYP3A4. Additive QTc prolongation may also occur. Concomitant therapy should be avoided.
Vorinostat Additive QTc prolongation may occur. Concomitant therapy should be avoided.
Ziprasidone Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Zuclopenthixol Additive QTc-prolonging effects increases risk of cardiac arrhythmias. Concomitant therapy should be avoided.
Food Interactions Not Available

Targets


Proto-oncogene tyrosine-protein kinase ABL1
Name Proto-oncogene tyrosine-protein kinase ABL1
Gene Name ABL1
Pharmacological action yes
Actions inhibitor
References
  • Maekawa T, Ashihara E, Kimura S: The Bcr-Abl tyrosine kinase inhibitor imatinib and promising new agents against Philadelphia chromosome-positive leukemias. Int J Clin Oncol. 2007 Oct;12(5):327-40. Epub 2007 Oct 22. - Pubmed
  • Kantarjian HM, Giles F, Gattermann N, Bhalla K, Alimena G, Palandri F, Ossenkoppele GJ, Nicolini FE, O'brien SG, Litzow M, Bhatia R, Cervantes F, Haque A, Shou Y, Resta DJ, Weitzman A, Hochhaus A, le Coutre P: Nilotinib (formerly AMN107), a highly selective Bcr-Abl tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood. 2007 Aug 22;. - Pubmed
  • Weisberg E, Manley P, Mestan J, Cowan-Jacob S, Ray A, Griffin JD: AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL. Br J Cancer. 2006 Jun 19;94(12):1765-9. Epub 2006 May 23. - Pubmed
  • Swords R, Mahalingam D, Padmanabhan S, Carew J, Giles F: Nilotinib: optimal therapy for patients with chronic myeloid leukemia and resistance or intolerance to imatinib. Drug Des Devel Ther. 2009 Sep 21;3:89-101. - Pubmed
  • Rosti G, Palandri F, Castagnetti F, Breccia M, Levato L, Gugliotta G, Capucci A, Cedrone M, Fava C, Intermesoli T, Cambrin GR, Stagno F, Tiribelli M, Amabile M, Luatti S, Poerio A, Soverini S, Testoni N, Martinelli G, Alimena G, Pane F, Saglio G, Baccarani M: Nilotinib for the frontline treatment of Ph(+) chronic myeloid leukemia. Blood. 2009 Dec 3;114(24):4933-8. Epub 2009 Oct 12. - Pubmed
DTHybrid score 0.8154
Mast/stem cell growth factor receptor
Name Mast/stem cell growth factor receptor
Gene Name KIT
Pharmacological action unknown
Actions antagonist
References
  • Guo T, Agaram NP, Wong GC, Hom G, D'Adamo D, Maki RG, Schwartz GK, Veach D, Clarkson BD, Singer S, DeMatteo RP, Besmer P, Antonescu CR: Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor. Clin Cancer Res. 2007 Aug 15;13(16):4874-81. - Pubmed
DTHybrid score 0.2019

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Tanaka C, Yin OQ, Smith T, Sethuraman V, Grouss K, Galitz L, Harrell R, Schran H: Effects of rifampin and ketoconazole on the pharmacokinetics of nilotinib in healthy participants. J Clin Pharmacol. 2011 Jan;51(1):75-83. Epub 2010 Aug 11. - Pubmed
  • Haouala A, Widmer N, Duchosal MA, Montemurro M, Buclin T, Decosterd LA: Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood. 2011 Feb 24;117(8):e75-87. Epub 2010 Sep 1. - Pubmed
  • Yin OQ, Gallagher N, Tanaka C, Fisher D, Sethuraman V, Zhou W, Lin TH, Heuman D, Schran H: Effects of hepatic impairment on the pharmacokinetics of nilotinib: an open-label, single-dose, parallel-group study. Clin Ther. 2009;31 Pt 2:2459-69. - Pubmed
  • Deremer DL, Ustun C, Natarajan K: Nilotinib: a second-generation tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia. Clin Ther. 2008 Nov;30(11):1956-75. - Pubmed
DTHybrid score 0.7008
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Haouala A, Widmer N, Duchosal MA, Montemurro M, Buclin T, Decosterd LA: Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood. 2011 Feb 24;117(8):e75-87. Epub 2010 Sep 1. - Pubmed
  • Deremer DL, Ustun C, Natarajan K: Nilotinib: a second-generation tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia. Clin Ther. 2008 Nov;30(11):1956-75. - Pubmed
DTHybrid score 0.4131
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Yin OQ, Gallagher N, Fischer D, Zhao L, Zhou W, Leroy E, Golor G, Schran H: Effects of nilotinib on single-dose warfarin pharmacokinetics and pharmacodynamics: a randomized, single-blind, two-period crossover study in healthy subjects. Clin Drug Investig. 2011;31(3):169-7http://www.drugbank.ca/lims/molecules/45129. doi: 10.2165/11538700-000000000-00000. - Pubmed
  • Haouala A, Widmer N, Duchosal MA, Montemurro M, Buclin T, Decosterd LA: Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood. 2011 Feb 24;117(8):e75-87. Epub 2010 Sep 1. - Pubmed
DTHybrid score 0.5075
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Haouala A, Widmer N, Duchosal MA, Montemurro M, Buclin T, Decosterd LA: Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood. 2011 Feb 24;117(8):e75-87. Epub 2010 Sep 1. - Pubmed
  • Deremer DL, Ustun C, Natarajan K: Nilotinib: a second-generation tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia. Clin Ther. 2008 Nov;30(11):1956-75. - Pubmed
DTHybrid score 0.5017
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inducer
References
  • Haouala A, Widmer N, Duchosal MA, Montemurro M, Buclin T, Decosterd LA: Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood. 2011 Feb 24;117(8):e75-87. Epub 2010 Sep 1. - Pubmed
DTHybrid score 0.3475

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. Epub 2009 Apr 11. - Pubmed
  • Hegedus C, Ozvegy-Laczka C, Apati A, Magocsi M, Nemet K, Orfi L, Keri G, Katona M, Takats Z, Varadi A, Szakacs G, Sarkadi B: Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. Epub 2009 Sep 28. - Pubmed
  • Haouala A, Widmer N, Duchosal MA, Montemurro M, Buclin T, Decosterd LA: Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood. 2011 Feb 24;117(8):e75-87. Epub 2010 Sep 1. - Pubmed
DTHybrid score 0.5222
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate,inhibitor
References
  • Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. Epub 2009 Apr 11. - Pubmed
  • Hegedus C, Ozvegy-Laczka C, Apati A, Magocsi M, Nemet K, Orfi L, Keri G, Katona M, Takats Z, Varadi A, Szakacs G, Sarkadi B: Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. Epub 2009 Sep 28. - Pubmed
  • Haouala A, Widmer N, Duchosal MA, Montemurro M, Buclin T, Decosterd LA: Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood. 2011 Feb 24;117(8):e75-87. Epub 2010 Sep 1. - Pubmed
DTHybrid score 0.3079
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions inhibitor
References
  • Haouala A, Widmer N, Duchosal MA, Montemurro M, Buclin T, Decosterd LA: Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood. 2011 Feb 24;117(8):e75-87. Epub 2010 Sep 1. - Pubmed
DTHybrid score 0.2326

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.3318
4200 Cytochrome P450 1A2 CYP1A2 0.2913
4118 Cytochrome P450 3A5 CYP3A5 0.2614
6107 Cytochrome P450 3A7 CYP3A7 0.1753
6013 Cytochrome P450 2E1 CYP2E1 0.1516
587 Serum albumin ALB 0.1271
6024 Cytochrome P450 1A1 CYP1A1 0.127
5718 Cytochrome P450 2A6 CYP2A6 0.1134
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1121
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1115
20 Prostaglandin G/H synthase 1 PTGS1 0.1107
862 Multidrug resistance-associated protein 1 ABCC1 0.0884
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0836
228 Beta platelet-derived growth factor receptor PDGFRB 0.0831
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.083
2599 Tyrosine-protein kinase HCK HCK 0.0787
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0784
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0776
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0774
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0763
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0717
492 Histamine H1 receptor HRH1 0.0714
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0705
407 Vascular endothelial growth factor receptor 2 KDR 0.0684
26 Vascular endothelial growth factor receptor 3 FLT4 0.0667
6106 Cytochrome P450 2C18 CYP2C18 0.0651
32 Vascular endothelial growth factor receptor 1 FLT1 0.0644
824 Sodium-dependent serotonin transporter SLC6A4 0.0638
1898 Cytochrome P450 1B1 CYP1B1 0.0634
290 Prostaglandin G/H synthase 2 PTGS2 0.063
1729 Solute carrier family 22 member 6 SLC22A6 0.0595
776 Bile salt export pump ABCB11 0.0573
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0566
6145 Solute carrier family 22 member 1 SLC22A1 0.0542
2164 Multidrug resistance-associated protein 4 ABCC4 0.0532
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0515
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0493
556 Alpha-1A adrenergic receptor ADRA1A 0.0477
6144 Solute carrier family 22 member 2 SLC22A2 0.0471
3811 Cytochrome P450 19A1 CYP19A1 0.0469
831 D(2) dopamine receptor DRD2 0.0467
502 5-hydroxytryptamine 2A receptor HTR2A 0.0466
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0459
847 Mu-type opioid receptor OPRM1 0.0453
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0436
165 FL cytokine receptor FLT3 0.0436
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0435
766 Beta-2 adrenergic receptor ADRB2 0.0424
136 Estrogen receptor ESR1 0.0416
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0413
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0412
3856 Fibroblast growth factor receptor 3 FGFR3 0.0404
467 Delta-type opioid receptor OPRD1 0.0402
5787 Angiopoietin-1 receptor TEK 0.0401
696 Kappa-type opioid receptor OPRK1 0.0386
6824 Tyrosine-protein kinase Lyn LYN 0.0382
936 Ephrin type-A receptor 2 EPHA2 0.0381
6142 Solute carrier family 22 member 8 SLC22A8 0.038
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0374
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0367
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0367
871 Glucocorticoid receptor NR3C1 0.0355
713 Sodium-dependent dopamine transporter SLC6A3 0.0354
731 HIV-1 protease HIV-1 protease 0.0351
823 Fibroblast growth factor receptor 2 FGFR2 0.0346
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0341
1618 High affinity nerve growth factor receptor NTRK1 0.0338
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0328
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0328
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0325
118 Organic cation/carnitine transporter 2 SLC22A5 0.0321
193 Beta-1 adrenergic receptor ADRB1 0.0316
844 Epidermal growth factor receptor EGFR 0.0313
318 Alpha-2A adrenergic receptor ADRA2A 0.0308
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0304
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0299
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0298
6143 Solute carrier family 22 member 7 SLC22A7 0.0292
320 5-hydroxytryptamine 1A receptor HTR1A 0.029
6147 Solute carrier family 22 member 3 SLC22A3 0.0287
146 Androgen receptor AR 0.0285
590 5-hydroxytryptamine 2C receptor HTR2C 0.0284
632 Alpha-1B adrenergic receptor ADRA1B 0.0282
6137 Multidrug resistance-associated protein 6 ABCC6 0.0279
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0278
465 Calmodulin CALM1 0.0277
817 DNA topoisomerase 2-alpha TOP2A 0.0276
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0275
6026 Alcohol dehydrogenase 6 ADH6 0.0266
3923 Cholinesterase BCHE 0.0262
468 Cytochrome P450 4A11 CYP4A11 0.0262
274 Muscarinic acetylcholine receptor M5 CHRM5 0.026
23 D(1A) dopamine receptor DRD1 0.0258
1024 Solute carrier family 22 member 11 SLC22A11 0.0254
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0254
6148 Multidrug resistance-associated protein 7 ABCC10 0.0247
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0246
5798 Mitogen-activated protein kinase 11 MAPK11 0.0245
3941 Amine oxidase [flavin-containing] A MAOA 0.0245
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0242
4604 Liver carboxylesterase 1 CES1 0.0241
122 P2Y purinoceptor 12 P2RY12 0.0237
1353 DNA topoisomerase 1 TOP1 0.0234
3552 DNA topoisomerase 1 topA 0.0234
341 5-hydroxytryptamine 3 receptor HTR3A 0.0234
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0231
2216 Fibroblast growth factor receptor 4 FGFR4 0.023
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0229
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0228
484 Tyrosine-protein kinase ABL2 ABL2 0.0227
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0226
260 Cytochrome P450 51 ERG11 0.0226
761 Cytochrome P450 51 ERG11 0.0226
3163 Cytochrome P450 51 cyp51 0.0226
6182 Cytochrome P450 2J2 CYP2J2 0.0226
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0225
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0223
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0223
4120 NADPH--cytochrome P450 reductase POR 0.0221
70 Type-1 angiotensin II receptor AGTR1 0.022
3810 Catechol O-methyltransferase COMT 0.0217
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0213
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0212
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.021
1063 Signal transducer and activator of transcription 5B STAT5B 0.021
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0207
6031 Cytochrome P450 3A43 CYP3A43 0.0206
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0205
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0205
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0204
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0202
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0198
891 Dihydropteroate synthase folP 0.0196
5359 Dihydropteroate synthase folP 0.0196
7175 Dihydropteroate synthase sulI 0.0196
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0194
6136 Multidrug resistance-associated protein 5 ABCC5 0.0193
789 Alpha-1D adrenergic receptor ADRA1D 0.0192
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0192
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0189
833 Organic cation/carnitine transporter 1 SLC22A4 0.0188
869 Estrogen receptor beta ESR2 0.0188
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0186
6141 Sodium/bile acid cotransporter SLC10A1 0.0186
638 D(3) dopamine receptor DRD3 0.0184
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0184
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0181
885 5-hydroxytryptamine 1B receptor HTR1B 0.0181
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0178
3939 Amine oxidase [flavin-containing] B MAOB 0.0177
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0176
1864 RET proto-oncogene RET 0.0172
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0172
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0171
29 Tubulin beta-1 chain TUBB1 0.017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.017
6102 Arylamine N-acetyltransferase 2 NAT2 0.0169
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0168
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0162
319 Opioid receptor, sigma 1 OPRS1 0.0161
6220 Aryl hydrocarbon receptor AHR 0.0161
6085 Fatty acid-binding protein, intestinal FABP2 0.0158
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0158
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0157
725 5-hydroxytryptamine 1D receptor HTR1D 0.0157
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0157
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0157
756 Sex hormone-binding globulin SHBG 0.0155
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0155
5880 Thrombopoietin receptor MPL 0.0153
811 Translocator protein TSPO 0.0152
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0151
117 Sterol O-acyltransferase 1 SOAT1 0.015
629 Alpha-2B adrenergic receptor ADRA2B 0.0149
614 Progesterone receptor PGR 0.0148
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0147
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0147
161 Tubulin beta chain TUBB 0.0146
312 Tubulin beta chain TUB2 0.0146
436 5-hydroxytryptamine 2B receptor HTR2B 0.0146
952 Dipeptidyl peptidase 4 DPP4 0.0143
380 Cytochrome P450 17A1 CYP17A1 0.0142
760 Fibroblast growth factor 1 FGF1 0.0138
474 Acetylcholinesterase ACHE 0.0137
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0136
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0136
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0135
1192 Sulfotransferase 1A1 SULT1A1 0.0134
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0133
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0131
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
373 Transthyretin TTR 0.0126
378 Alpha-2C adrenergic receptor ADRA2C 0.0124
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0124
124 Histamine H2 receptor HRH2 0.0121
4773 Deoxycytidine kinase DCK 0.0121
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0118
818 50S ribosomal protein L10 rplJ 0.0117
432 D(4) dopamine receptor DRD4 0.0117
365 Dihydrofolate reductase DHFR 0.0115
2381 Dihydrofolate reductase DFR1 0.0115
2833 Dihydrofolate reductase Not Available 0.0115
2931 Dihydrofolate reductase folA 0.0115
3544 Dihydrofolate reductase folA 0.0115
3682 Dihydrofolate reductase folA 0.0115
6642 Dihydrofolate reductase folA 0.0115
6756 Dihydrofolate reductase dfrA 0.0115
174 Sigma 1-type opioid receptor SIGMAR1 0.0114
738 Monocarboxylate transporter 1 SLC16A1 0.0113
3947 Xanthine dehydrogenase/oxidase XDH 0.0113
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0111
1656 CYP2B protein CYP2B 0.011
1757 Myeloperoxidase MPO 0.0107
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0107
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0107
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0107
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0107
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0107
716 5-hydroxytryptamine 7 receptor HTR7 0.0106
6599 HTH-type transcriptional regulator ttgR ttgR 0.0105
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0105
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0104
904 Glutathione S-transferase P GSTP1 0.0103
232 Corticosteroid-binding globulin SERPINA6 0.0103
2240 Cell division protein kinase 2 CDK2 0.0102
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0101
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.01
1010 Cytochrome P450 51A1 CYP51A1 0.0099
908 Glutathione S-transferase theta-1 GSTT1 0.0099
94 5-hydroxytryptamine 4 receptor HTR4 0.0099
275 Arachidonate 5-lipoxygenase ALOX5 0.0098
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0097
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0097
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0097
2539 Tubulin alpha-1 chain TUBA4A 0.0096
33 Cystine/glutamate transporter SLC7A11 0.0096
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0096
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0095
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0095
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0095
482 Glycine receptor subunit alpha-1 GLRA1 0.0095
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0095
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0093
992 Protein tyrosine kinase 2 beta PTK2B 0.0092
777 Tumor necrosis factor TNF 0.0092
24 Thymidylate synthase TMP1 0.0092
359 Thymidylate synthase TYMS 0.0092
2626 Thymidylate synthase thyA 0.0092
2729 Thymidylate synthase thyA 0.0092
5352 Thymidylate synthase THYA 0.0092
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0091
131 Synaptic vesicular amine transporter SLC18A2 0.0091
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.009
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
737 Mineralocorticoid receptor NR3C2 0.0088
427 Substance-P receptor TACR1 0.0088
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0088
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0088
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0088
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0088
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0087
1050 Bile salt sulfotransferase SULT2A1 0.0087
295 Carbonic anhydrase 1 CA1 0.0086
6138 Multidrug resistance protein 3 ABCB4 0.0086
273 Apoptosis regulator Bcl-2 BCL2 0.0085
1760 Aminopeptidase N ANPEP 0.0085
6843 Aminopeptidase N pepN 0.0085
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0085
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0085
3809 Estrogen-related receptor gamma ESRRG 0.0084
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0084
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0083
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0083
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0083
1630 Integrin beta-2 ITGB2 0.0083
6014 Cytochrome P450 2A13 CYP2A13 0.0083
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0082
68 Cannabinoid receptor 1 CNR1 0.0081
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0081
1852 Microtubule-associated protein 2 MAP2 0.0081
163 D(1B) dopamine receptor DRD5 0.0081
4203 Histamine N-methyltransferase HNMT 0.0081
606 Cytochrome P450 27, mitochondrial CYP27A1 0.008
1275 Estrogen sulfotransferase SULT1E1 0.008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0079
6146 High affinity copper uptake protein 1 SLC31A1 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
2112 Toll-like receptor 9 TLR9 0.0079
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0078
2616 Ganglioside GM2 activator GM2A 0.0078
469 Annexin A1 ANXA1 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
6020 Aldehyde oxidase AOX1 0.0076
705 Glutamate receptor 1 GRIA1 0.0076
4122 Histone deacetylase 2 HDAC2 0.0075
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0075
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
1541 Metalloproteinase mmp20 0.0074
592 Carbonic anhydrase 4 CA4 0.0073
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0073
4192 DNA topoisomerase 2-beta TOP2B 0.0072
88 Retinoic acid receptor RXR-beta RXRB 0.0072
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0072
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0071
537 ATP synthase delta chain, mitochondrial ATP5D 0.007
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.007
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.007
1629 Transcription factor AP-1 JUN 0.007
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.007
49 Endothelin B receptor EDNRB 0.0069
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0069
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0069
5300 Antigen peptide transporter 1 TAP1 0.0068
3932 Glutathione S-transferase A2 GSTA2 0.0068
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0068
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0068
183 Vascular endothelial growth factor A VEGFA 0.0067
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0067
1178 Adenosine A2a receptor ADORA2A 0.0067
284 DNA-directed RNA polymerase beta chain rpoB 0.0066
5773 DNA-directed RNA polymerase beta chain rpoB 0.0066
340 Apoptotic protease-activating factor 1 APAF1 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0065
856 Vitamin D3 receptor VDR 0.0064
768 FK506-binding protein 1A FKBP1A 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
2981 Phospholipase A2, membrane associated PLA2G2A 0.0063
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0063
133 Dihydropterate synthase sulI 0.0063
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0063
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0063
4237 50S ribosomal protein L22 rplV 0.0062
239 Coagulation factor X F10 0.0062
921 Glutamate receptor 2 GRIA2 0.0062
2449 Tubulin alpha-3 chain TUBA1A 0.0062
84 Nuclear receptor 0B1 NR0B1 0.0061
814 Ryanodine receptor 1 RYR1 0.0061
5923 Microtubule-associated protein tau MAPT 0.006
5924 Microtubule-associated protein 4 MAP4 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.006
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
322 Vasopressin V2 receptor AVPR2 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
1256 5-hydroxytryptamine 6 receptor HTR6 0.0058
6163 Copper-transporting ATPase 2 ATP7B 0.0057
6165 Copper-transporting ATPase 1 ATP7A 0.0057
6044 Serum paraoxonase/lactonase 3 PON3 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
4210 Toll-like receptor 4 TLR4 0.0057
511 5-hydroxytryptamine 1F receptor HTR1F 0.0057
6043 Putative G-protein coupled receptor 44 GPR44 0.0056
528 5-hydroxytryptamine 1E receptor HTR1E 0.0056
581 Cytochrome P450 2R1 CYP2R1 0.0056
780 Retinoic acid receptor RXR-gamma RXRG 0.0055
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0055
7 Nitric oxide synthase, inducible NOS2 0.0055
6506 Stathmin-4 STMN4 0.0055
357 Carbonic anhydrase 2 CA2 0.0055
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0055
896 Glutathione S-transferase Mu 1 GSTM1 0.0055
106 Cannabinoid receptor 2 CNR2 0.0054
477 DNA topoisomerase 4 subunit A parC 0.0054
886 DNA topoisomerase 4 subunit A parC 0.0054
6226 DNA topoisomerase 4 subunit A parC 0.0054
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0053
404 DNA gyrase subunit A gyrA 0.0053
6224 DNA gyrase subunit A gyrA 0.0053
1650 Heme carrier protein 1 SLC46A1 0.0053
572 Integrin alpha-L ITGAL 0.0053
1262 Corticotropin-lipotropin POMC 0.0052
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
267 Plasminogen activator inhibitor 1 SERPINE1 0.0051
6755 Poliovirus receptor PVR 0.0051
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0051
461 Glycine receptor subunit alpha-3 GLRA3 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4103 Proteasome subunit beta type 2 PSMB2 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
4102 Proteasome subunit beta type 5 PSMB5 0.005
4101 Proteasome subunit beta type 1 PSMB1 0.005
3937 Fatty-acid amide hydrolase FAAH 0.005
16 Adenosine A1 receptor ADORA1 0.005
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0049
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0049
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0049
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0049
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0049
173 Toll-like receptor 7 TLR7 0.0049
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0049
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0049
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0047
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
4692 A/G-specific adenine glycosylase mutY 0.0047
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0047
162 Retinoic acid receptor gamma-1 RARG 0.0047
2021 Thrombomodulin THBD 0.0047
6221 Steroid hormone receptor ERR1 ESRRA 0.0047
3917 Methylenetetrahydrofolate reductase MTHFR 0.0047
518 Peroxidase/catalase T katG 0.0047
683 Potassium transporter GK0582 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
1648 Elastin ELN 0.0046
6149 Solute carrier family 22 member 10 SLC22A10 0.0046
6126 Carbonic anhydrase 7 CA7 0.0046
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0045
6228 Nuclear receptor coactivator 1 NCOA1 0.0045
54 Prothrombin F2 0.0045
527 Prostacyclin receptor PTGIR 0.0045
3086 Plasmepsin-2 Not Available 0.0045
6432 Transporter snf 0.0045
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0045
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0045
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0044
292 Activin receptor type-1 ACVR1 0.0044
849 Activated CDC42 kinase 1 TNK2 0.0044
702 UMP-CMP kinase CMPK1 0.0044
563 Thyroid peroxidase TPO 0.0044
130 Prostacyclin synthase PTGIS 0.0044
4217 Telomerase reverse transcriptase TERT 0.0043
1992 Vitamin D-binding protein GC 0.0043
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0042
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0042
395 ALK tyrosine kinase receptor Not Available 0.0042
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0042
733 Activin receptor type 1B ACVR1B 0.0042
825 Arsenical pump-driving ATPase ASNA1 0.0042
3435 Arsenical pump-driving ATPase arsA 0.0042
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0042
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0042
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0042
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0042
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0042
154 AFG3-like protein 2 AFG3L2 0.0042
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0042
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0042
6174 50S ribosomal protein L32 rpmF 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0041
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0041
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0041
394 Calcineurin subunit B isoform 1 PPP3R1 0.0041
6753 Apolipoprotein M APOM 0.0041
6742 Recoverin RCVRN 0.0041
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0041
6747 Chalcone/stilbene synthase family protein MT1417 0.0041
6743 Non-fluorescent flavoprotein luxF 0.0041
2528 Fatty acid metabolism regulator protein fadR 0.0041
6740 Fatty acid metabolism regulator protein fadR 0.0041
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0041
6751 Gag polyprotein gag 0.0041
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0041
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0041
6749 Polyprotein Not Available 0.0041
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.004
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.004
2297 Genome polyprotein Not Available 0.004
2322 Genome polyprotein Not Available 0.004
2694 Genome polyprotein Not Available 0.004
2719 Genome polyprotein Not Available 0.004
2860 Genome polyprotein Not Available 0.004
2928 Genome polyprotein Not Available 0.004
3160 Genome polyprotein Not Available 0.004
3260 Genome polyprotein Not Available 0.004
4783 Genome polyprotein Not Available 0.004
5726 Genome polyprotein Not Available 0.004
5779 Genome polyprotein Not Available 0.004
5867 Genome polyprotein Not Available 0.004
6253 Genome polyprotein Not Available 0.004
6301 Genome polyprotein Not Available 0.004
6380 Genome polyprotein Not Available 0.004
6381 Genome polyprotein Not Available 0.004
6437 Genome polyprotein Not Available 0.004
6520 Genome polyprotein Not Available 0.004
6521 Genome polyprotein Not Available 0.004
6652 Genome polyprotein Not Available 0.004
6734 Genome polyprotein Not Available 0.004
6735 Genome polyprotein Not Available 0.004
6736 Genome polyprotein Not Available 0.004
6737 Genome polyprotein Not Available 0.004
6738 Genome polyprotein Not Available 0.004
6739 Genome polyprotein Not Available 0.004
6744 Genome polyprotein Not Available 0.004
6748 Genome polyprotein Not Available 0.004
6894 Genome polyprotein Not Available 0.004
6898 Genome polyprotein Not Available 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
1517 Beta-3 adrenergic receptor ADRB3 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0039
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
3639 Thymidine phosphorylase deoA 0.0037
3936 Thymidine phosphorylase TYMP 0.0037
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
6167 Organic solute transporter subunit beta OSTB 0.0037
6166 Organic solute transporter subunit alpha OSTA 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
661 ADP/ATP translocase 1 SLC25A4 0.0037
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0037
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0037
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0037
297 Adenylate cyclase type 1 ADCY1 0.0037
4311 tRNA TRDMT1 0.0037
4325 tRNA trmD 0.0037
4328 tRNA trmD 0.0037
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0036
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
5961 Insulin INS 0.0036
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0036
6527 Lymphocyte antigen 96 LY96 0.0036
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0036
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
164 Histamine H4 receptor HRH4 0.0035
6837 Serine/threonine-protein kinase 17B STK17B 0.0035
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0035
939 50S ribosomal protein L3 rplC 0.0035
293 Gamma-glutamyl hydrolase GGH 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
2320 Thymidine kinase, cytosolic TK1 0.0034
976 Platelet glycoprotein IX GP9 0.0034
6750 ADP-ribosylation factor 6 ARF6 0.0033
6021 Adenosine kinase ADK 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0033
153 Dopamine beta-hydroxylase DBH 0.0033
6524 Protein tonB tonB 0.0033
4226 Uridine phosphorylase 2 UPP2 0.0033
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0033
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0033
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0033
1792 Tissue-type plasminogen activator PLAT 0.0032
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0032
489 Monocarboxylate transporter 2 SLC16A7 0.0032
229 Retinoic acid receptor beta RARB 0.0032
6316 ADP-ribosylation factor 1 ARF1 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0031
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
291 Nitric-oxide synthase, endothelial NOS3 0.0031
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0031
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0031
5934 Cytochrome P450 26A1 CYP26A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
740 Argininosuccinate synthase ASS1 0.0031
865 Argininosuccinate synthase ASS1 0.0031
2680 Argininosuccinate synthase argG 0.0031
3194 Argininosuccinate synthase argG 0.0031
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
4225 Uridine phosphorylase 1 UPP1 0.003
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.003
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.003
751 Potassium channel subfamily K member 6 KCNK6 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.003
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.003
215 Sodium channel protein type 11 subunit alpha SCN11A 0.003
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.003
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.003
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
6048 Troponin C, skeletal muscle TNNC2 0.0029
6042 Prostaglandin reductase 2 PTGR2 0.0029
5294 Nucleoside diphosphate kinase A NME1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
719 Retinoic acid receptor responder protein 1 RARRES1 0.0028
770 Retinoic acid-induced protein 3 GPRC5A 0.0028
605 Fumarate reductase flavoprotein subunit frdA 0.0028
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0028
3673 Fumarate reductase flavoprotein subunit fccA 0.0028
4912 Fumarate reductase flavoprotein subunit ifcA 0.0028
6549 Fumarate reductase flavoprotein subunit frdA 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
413 Amidophosphoribosyltransferase PPAT 0.0028
2515 Amidophosphoribosyltransferase purF 0.0028
3714 Amidophosphoribosyltransferase purF 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
172 Potassium channel subfamily K member 1 KCNK1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
2207 Rhodopsin RHO 0.0027
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0026
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0026
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0026
864 Gag-Pol polyprotein gag-pol 0.0026
2237 Gag-Pol polyprotein gag-pol 0.0026
2326 Gag-Pol polyprotein gag-pol 0.0026
2451 Gag-Pol polyprotein gag-pol 0.0026
2901 Gag-Pol polyprotein gag-pol 0.0026
3165 Gag-Pol polyprotein gag-pol 0.0026
3722 Gag-Pol polyprotein gag-pol 0.0026
6306 Gag-Pol polyprotein gag-pol 0.0026
6624 Gag-Pol polyprotein gag-pol 0.0026
6168 Solute carrier family 22 member 16 SLC22A16 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0026
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0026
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0026
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0026
5304 UPF0166 protein TM_0021 TM_0021 0.0025
5293 Shikimate kinase 2 aroL 0.0025
5266 Activator of hgdC 0.0025
5287 Signaling protein Not Available 0.0025
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0025
5292 Putative partitioning protein TT_C1605 0.0025
3199 Phosphopantetheine adenylyltransferase coaD 0.0025
3543 Phosphopantetheine adenylyltransferase coaD 0.0025
3567 Phosphopantetheine adenylyltransferase coaD 0.0025
5289 Phosphopantetheine adenylyltransferase coaD 0.0025
5281 Plasmid segregation protein parM parM 0.0025
2874 Nitrogenase iron protein 1 nifH1 0.0025
4346 Polynucleotide kinase pseT 0.0025
5283 D-alanine--D-alanine ligase B ddlB 0.0025
5288 Shikimate kinase aroK 0.0025
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0025
5299 D-alanine--D-alanine ligase ddl 0.0025
6598 D-alanine--D-alanine ligase ddl 0.0025
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0025
5276 Chromosomal replication initiator protein dnaA dnaA 0.0025
5315 Chaperone protein htpG htpG 0.0025
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0025
5259 Transcriptional regulator ntrC1 0.0025
6699 Transcriptional regulator Cgl2612 0.0025
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5284 Large T antigen Not Available 0.0025
5291 Glycogen synthase 1 glgA1 0.0025
5264 DNA replication protein REP 0.0025
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0025
5285 Kinesin heavy chain KIF5B 0.0025
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0025
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0025
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0025
5261 Phosphoribosylformylglycinamidine synthase purL 0.0025
5277 Preprotein translocase subunit secA secA 0.0025
5308 Preprotein translocase secA 1 subunit secA1 0.0025
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0025
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0025
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0025
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0025
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0025
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
569 Retinal dehydrogenase 2 ALDH1A2 0.0025
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0025
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
3808 Dihydropteroate synthase 2 folP2 0.0025
3601 Dihydropteroate synthase 1 folP1 0.0025
3807 Dihydropteroate synthase 1 folP1 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
3957 Adenosine deaminase ADA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
1374 Natriuretic peptides B NPPB 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
1827 Gap junction alpha-1 protein GJA1 0.0024
1908 Vascular cell adhesion protein 1 VCAM1 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
2427 Ferrichrome-iron receptor fhuA 0.0023
1341 Histamine H3 receptor HRH3 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
444 Alcohol dehydrogenase 1B ADH1B 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
1313 Lactoylglutathione lyase GLO1 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
1039 Histone deacetylase 9 HDAC9 0.0022
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2091 Endoplasmin HSP90B1 0.0022
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0022
251 Alcohol dehydrogenase 1A ADH1A 0.0022
2232 Interleukin-5 IL5 0.0022
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0021
76 Nitric-oxide synthase, brain NOS1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
3470 Hypothetical protein MG245 homolog MPN_348 0.0021
6277 Heat shock cognate 71 kDa protein HSPA8 0.0021
5189 Trimethylamine dehydrogenase tmd 0.002
4106 Guanylate kinase GUK1 0.002
4516 Guanylate kinase gmk 0.002
4837 Cag-alfa cag-alfa 0.002
5646 Galactokinase GALK1 0.002
3390 Aminoglycoside 3'-phosphotransferase aphA 0.002
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.002
5302 TrwB trwB 0.002
4774 NTPase P4 Not Available 0.002
4839 DNA polymerase III subunit tau dnaX 0.002
5265 FtsH ftsH 0.002
4838 PMS1 protein homolog 2 PMS2 0.002
2270 Dephospho-CoA kinase coaE 0.002
2284 Adenylate kinase adk 0.002
2296 Adenylate kinase adk 0.002
2311 Adenylate kinase adk 0.002
2312 Adenylate kinase Not Available 0.002
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.002
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
3426 Glutamine synthetase glnA 0.002
3987 Glutamine synthetase GLUL 0.002
3175 Glutamate--cysteine ligase gshA 0.002
5626 Nucleoside diphosphate kinase B NME2 0.002
6459 Glycodelin PAEP 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
820 Glycine receptor subunit alpha-2 GLRA2 0.002
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0019
2683 Mono-ADP-ribosyltransferase C3 C3 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0019
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
517 Alcohol dehydrogenase 1C ADH1C 0.0019
1360 Sphingomyelin phosphodiesterase SMPD1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
5271 Focal adhesion kinase 1 PTK2 0.0018
2390 Nonsecretory ribonuclease RNASE2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
5312 Kinesin-like protein KIF1A KIF1A 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
2922 Glycerol kinase glpK 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
6218 Pannexin-1 PANX1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
3587 Gastrotropin FABP6 0.0017
1721 Glycogen synthase kinase-3 beta GSK3B 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0017
408 Riboflavin kinase RFK 0.0017
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0017
2615 Chemotaxis protein cheA cheA 0.0017
2371 Pantothenate kinase coaA 0.0017
2282 Protein recA recA 0.0017
2315 Protein recA recA 0.0017
2332 Protein recA recA 0.0017
5263 Protein recA recA 0.0017
2892 Acetylglutamate kinase argB 0.0017
3550 Acetylglutamate kinase argB 0.0017
3669 Ribokinase rbsK 0.0017
1881 Hexokinase-1 HK1 0.0017
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0017
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
2727 S-adenosylmethionine synthetase metK 0.0016
788 Creatine kinase M-type CKM 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
2697 Uridine-cytidine kinase 2 UCK2 0.0015
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0015
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
2334 Dethiobiotin synthetase bioD 0.0015
6555 Dethiobiotin synthetase bioD 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
48 Pyridoxal kinase PDXK 0.0015
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0014
6395 Myosin-14 MYH14 0.0014
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0014
5818 Folate receptor alpha FOLR1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
2251 Thymidylate kinase tmk 0.0014
2254 Thymidylate kinase DTYMK 0.0014
3522 Thymidylate kinase tmk 0.0014
3221 Cytochrome c4 cc4 0.0014
1422 Serine/threonine-protein kinase 6 AURKA 0.0014
207 Glutathione synthetase GSS 0.0014
5269 Glutathione synthetase gshB 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
3379 Kinesin-like protein KIF11 KIF11 0.0013
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
3822 Actin, alpha skeletal muscle ACTA1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
509 Thymidine kinase TK 0.0012
570 Thymidine kinase TK 0.0012
2559 Thymidine kinase TK 0.0012
3430 Thymidine kinase tdk 0.0012
3518 Thymidine kinase TK 0.0012
5301 Thymidine kinase tdk 0.0012
5771 Thymidine kinase ORF36 0.0012
7009 Thymidine kinase ORF36 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
5682 Ribonuclease pancreatic RNASE1 0.0011
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2298 Cytochrome P450-cam camC 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
3830 Calreticulin CALR 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
2230 Catalase CAT 0.0006
3249 Catalase katA 0.0006
3625 Catalase katA 0.0006
4539 Catalase katA 0.0006
4941 Catalase katB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0004
2802 Endoglucanase G celCCG 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
↑