DT-Web

DB00804 - Dicyclomine


Identification
Name Dicyclomine
Accession Number DB00804 (APRD00113)
Type small molecule
Description A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 309.4867
Groups approved
Monoisotopic Weight 309.266779369
Pharmacology
Indication For the treatment of functional bowel/irritable bowel syndrome including Colicky abdominal pain; diverticulitis
Mechanism of action Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Absorption Not Available
Protein binding >99%
Biotransformation Not Available
Route of elimination The principal route of elimination is via the urine (79.5% of the dose). Excretion also occurs in the feces, but to a lesser extent (8.4%).
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
Rivastigmine Possible antagonism of action
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Dicyclomine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Trimethobenzamide Trimethobenzamide and Dicyclomine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine Triprolidine and Dicyclomine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trospium Trospium and Dicyclomine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Food Interactions
  • Avoid alcohol.
  • Take this medication 30 minutes before meals.

Targets


Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Jin CH, Shin EJ, Park JB, Jang CG, Li Z, Kim MS, Koo KH, Yoon HJ, Park SJ, Choi WC, Yamada K, Nabeshima T, Kim HC: Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment. J Neurosci Res. 2009 Dec;87(16):3658-70. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5216
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action unknown
Actions antagonist
References
  • Pavia J, Munoz M, Jimenez E, Martos F, Gonzalez-Correa JA, De la Cruz JP, Garcia V, Sanchez de la Cuesta F: Pharmacological characterization and distribution of muscarinic receptors in human placental syncytiotrophoblast brush-border and basal plasma membranes. Eur J Pharmacol. 1997 Feb 12;320(2-3):209-14. - Pubmed
DTHybrid score 0.4015

Enzymes


Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1643

Predictions


Id Partner name Gene Name Score
51 Muscarinic acetylcholine receptor M3 CHRM3 0.2566
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1513
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1219
4119 Cytochrome P450 2D6 CYP2D6 0.0957
4512 Cytochrome P450 3A4 CYP3A4 0.0893
4200 Cytochrome P450 1A2 CYP1A2 0.0867
492 Histamine H1 receptor HRH1 0.0671
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.061
1588 Multidrug resistance protein 1 ABCB1 0.0606
3923 Cholinesterase BCHE 0.05
6013 Cytochrome P450 2E1 CYP2E1 0.0454
6016 Cytochrome P450 2C19 CYP2C19 0.0449
4757 Cytochrome P450 2C9 CYP2C9 0.0447
502 5-hydroxytryptamine 2A receptor HTR2A 0.038
4118 Cytochrome P450 3A5 CYP3A5 0.0374
4924 Cytochrome P450 2C8 CYP2C8 0.037
831 D(2) dopamine receptor DRD2 0.0349
556 Alpha-1A adrenergic receptor ADRA1A 0.0312
6030 Cytochrome P450 2B6 CYP2B6 0.0312
5718 Cytochrome P450 2A6 CYP2A6 0.03
23 D(1A) dopamine receptor DRD1 0.0263
590 5-hydroxytryptamine 2C receptor HTR2C 0.0258
1898 Cytochrome P450 1B1 CYP1B1 0.0254
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0231
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0225
6107 Cytochrome P450 3A7 CYP3A7 0.0199
824 Sodium-dependent serotonin transporter SLC6A4 0.0196
6145 Solute carrier family 22 member 1 SLC22A1 0.0178
833 Organic cation/carnitine transporter 1 SLC22A4 0.0176
6144 Solute carrier family 22 member 2 SLC22A2 0.0172
789 Alpha-1D adrenergic receptor ADRA1D 0.0171
632 Alpha-1B adrenergic receptor ADRA1B 0.0162
341 5-hydroxytryptamine 3 receptor HTR3A 0.015
118 Organic cation/carnitine transporter 2 SLC22A5 0.0149
320 5-hydroxytryptamine 1A receptor HTR1A 0.0149
318 Alpha-2A adrenergic receptor ADRA2A 0.0148
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0147
432 D(4) dopamine receptor DRD4 0.0137
436 5-hydroxytryptamine 2B receptor HTR2B 0.0129
723 Cytosolic phospholipase A2 PLA2G4A 0.0124
638 D(3) dopamine receptor DRD3 0.0123
124 Histamine H2 receptor HRH2 0.0122
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0118
48 Pyridoxal kinase PDXK 0.0116
378 Alpha-2C adrenergic receptor ADRA2C 0.0108
629 Alpha-2B adrenergic receptor ADRA2B 0.0106
468 Cytochrome P450 4A11 CYP4A11 0.0106
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0103
20 Prostaglandin G/H synthase 1 PTGS1 0.01
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0099
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0099
587 Serum albumin ALB 0.0096
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0096
713 Sodium-dependent dopamine transporter SLC6A3 0.0096
2129 Sucrase-isomaltase, intestinal SI 0.0094
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0094
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0093
6106 Cytochrome P450 2C18 CYP2C18 0.0093
528 5-hydroxytryptamine 1E receptor HTR1E 0.0088
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0087
1656 CYP2B protein CYP2B 0.0087
6014 Cytochrome P450 2A13 CYP2A13 0.0084
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
6147 Solute carrier family 22 member 3 SLC22A3 0.0082
1256 5-hydroxytryptamine 6 receptor HTR6 0.0082
776 Bile salt export pump ABCB11 0.008
193 Beta-1 adrenergic receptor ADRB1 0.008
474 Acetylcholinesterase ACHE 0.0079
2499 Tubulin beta-2C chain TUBB2C 0.0079
465 Calmodulin CALM1 0.0078
777 Tumor necrosis factor TNF 0.0077
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0075
885 5-hydroxytryptamine 1B receptor HTR1B 0.0075
163 D(1B) dopamine receptor DRD5 0.0075
716 5-hydroxytryptamine 7 receptor HTR7 0.0074
136 Estrogen receptor ESR1 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0072
2449 Tubulin alpha-3 chain TUBA1A 0.0072
1729 Solute carrier family 22 member 6 SLC22A6 0.0072
766 Beta-2 adrenergic receptor ADRB2 0.0068
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0067
1517 Beta-3 adrenergic receptor ADRB3 0.0067
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0066
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0066
725 5-hydroxytryptamine 1D receptor HTR1D 0.0066
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0062
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.006
790 DNA polymerase subunit alpha B POLA2 0.0058
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0056
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0055
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0054
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
871 Glucocorticoid receptor NR3C1 0.0052
290 Prostaglandin G/H synthase 2 PTGS2 0.0051
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0051
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.005
862 Multidrug resistance-associated protein 1 ABCC1 0.005
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.005
820 Glycine receptor subunit alpha-2 GLRA2 0.005
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0049
380 Cytochrome P450 17A1 CYP17A1 0.0049
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0048
3932 Glutathione S-transferase A2 GSTA2 0.0047
3811 Cytochrome P450 19A1 CYP19A1 0.0047
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0047
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0046
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0045
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0045
1820 Beta-nerve growth factor NGF 0.0044
4228 Keratin, type II cytoskeletal 7 KRT7 0.0044
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0043
1714 Mitogen-activated protein kinase 3 MAPK3 0.0041
6142 Solute carrier family 22 member 8 SLC22A8 0.0041
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0041
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.004
33 Cystine/glutamate transporter SLC7A11 0.004
6766 O-GlcNAcase BT_4395 BT_4395 0.004
6432 Transporter snf 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1176 Mitogen-activated protein kinase 1 MAPK1 0.0038
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0037
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0037
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0037
94 5-hydroxytryptamine 4 receptor HTR4 0.0036
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
844 Epidermal growth factor receptor EGFR 0.0034
4203 Histamine N-methyltransferase HNMT 0.0034
1757 Myeloperoxidase MPO 0.0034
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0034
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0033
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0033
1010 Cytochrome P450 51A1 CYP51A1 0.0033
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0033
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0032
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0032
198 Sodium channel protein type 10 subunit alpha SCN10A 0.003
2112 Toll-like receptor 9 TLR9 0.0029
6220 Aryl hydrocarbon receptor AHR 0.0029
3941 Amine oxidase [flavin-containing] A MAOA 0.0029
6148 Multidrug resistance-associated protein 7 ABCC10 0.0028
6146 High affinity copper uptake protein 1 SLC31A1 0.0028
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0027
1360 Sphingomyelin phosphodiesterase SMPD1 0.0027
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0027
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0027
4311 tRNA TRDMT1 0.0027
4325 tRNA trmD 0.0027
4328 tRNA trmD 0.0027
2236 Casein kinase II subunit alpha CSNK2A1 0.0027
3947 Xanthine dehydrogenase/oxidase XDH 0.0026
106 Cannabinoid receptor 2 CNR2 0.0026
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0026
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0026
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0025
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0025
68 Cannabinoid receptor 1 CNR1 0.0025
6043 Putative G-protein coupled receptor 44 GPR44 0.0024
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0024
817 DNA topoisomerase 2-alpha TOP2A 0.0024
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0024
16 Adenosine A1 receptor ADORA1 0.0024
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0024
1178 Adenosine A2a receptor ADORA2A 0.0023
146 Androgen receptor AR 0.0023
164 Histamine H4 receptor HRH4 0.0023
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0023
1569 G1/S-specific cyclin-D1 CCND1 0.0023
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0023
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0023
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0023
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
84 Nuclear receptor 0B1 NR0B1 0.0022
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0022
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0022
1192 Sulfotransferase 1A1 SULT1A1 0.0022
5934 Cytochrome P450 26A1 CYP26A1 0.0022
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0021
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0021
373 Transthyretin TTR 0.0021
823 Fibroblast growth factor receptor 2 FGFR2 0.0021
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0021
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.002
606 Cytochrome P450 27, mitochondrial CYP27A1 0.002
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0019
1629 Transcription factor AP-1 JUN 0.0019
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0019
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
122 P2Y purinoceptor 12 P2RY12 0.0019
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0019
1618 High affinity nerve growth factor receptor NTRK1 0.0019
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0019
3830 Calreticulin CALR 0.0018
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0018
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0018
1992 Vitamin D-binding protein GC 0.0018
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0018
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0018
1024 Solute carrier family 22 member 11 SLC22A11 0.0017
6034 Hydroxyindole O-methyltransferase ASMT 0.0017
6035 Nuclear receptor ROR-beta RORB 0.0017
6036 Eosinophil peroxidase EPX 0.0017
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0017
976 Platelet glycoprotein IX GP9 0.0017
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
477 DNA topoisomerase 4 subunit A parC 0.0016
886 DNA topoisomerase 4 subunit A parC 0.0016
6226 DNA topoisomerase 4 subunit A parC 0.0016
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0016
1063 Signal transducer and activator of transcription 5B STAT5B 0.0016
4103 Proteasome subunit beta type 2 PSMB2 0.0016
4102 Proteasome subunit beta type 5 PSMB5 0.0016
4101 Proteasome subunit beta type 1 PSMB1 0.0016
404 DNA gyrase subunit A gyrA 0.0016
6224 DNA gyrase subunit A gyrA 0.0016
295 Carbonic anhydrase 1 CA1 0.0016
814 Ryanodine receptor 1 RYR1 0.0016
6182 Cytochrome P450 2J2 CYP2J2 0.0016
822 Aldose reductase AKR1B1 0.0016
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
2164 Multidrug resistance-associated protein 4 ABCC4 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
765 Indoleamine 2,3-dioxygenase IDO1 0.0015
251 Alcohol dehydrogenase 1A ADH1A 0.0015
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0015
6141 Sodium/bile acid cotransporter SLC10A1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0014
6031 Cytochrome P450 3A43 CYP3A43 0.0014
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
422 Vitamin K-dependent protein C PROC 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
571 Melatonin receptor type 1A MTNR1A 0.0014
362 Melatonin receptor type 1B MTNR1B 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0013
6143 Solute carrier family 22 member 7 SLC22A7 0.0013
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0013
856 Vitamin D3 receptor VDR 0.0013
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0013
484 Tyrosine-protein kinase ABL2 ABL2 0.0013
444 Alcohol dehydrogenase 1B ADH1B 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0013
756 Sex hormone-binding globulin SHBG 0.0013
183 Vascular endothelial growth factor A VEGFA 0.0013
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0013
4192 DNA topoisomerase 2-beta TOP2B 0.0013
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
6136 Multidrug resistance-associated protein 5 ABCC5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
4122 Histone deacetylase 2 HDAC2 0.0012
467 Delta-type opioid receptor OPRD1 0.0012
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0012
696 Kappa-type opioid receptor OPRK1 0.0012
1275 Estrogen sulfotransferase SULT1E1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0012
869 Estrogen receptor beta ESR2 0.0012
634 Squalene monooxygenase SQLE 0.0011
7196 Squalene monooxygenase ERG1 0.0011
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0011
908 Glutathione S-transferase theta-1 GSTT1 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
517 Alcohol dehydrogenase 1C ADH1C 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0011
798 Osteocalcin BGLAP 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
6102 Arylamine N-acetyltransferase 2 NAT2 0.0011
504 Mast/stem cell growth factor receptor KIT 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
1050 Bile salt sulfotransferase SULT2A1 0.0011
751 Potassium channel subfamily K member 6 KCNK6 0.0011
3007 Carbonic anhydrase 12 CA12 0.0011
4205 Carbonic anhydrase 9 CA9 0.0011
6137 Multidrug resistance-associated protein 6 ABCC6 0.0011
4120 NADPH--cytochrome P450 reductase POR 0.0011
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0011
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0011
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0011
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0011
6126 Carbonic anhydrase 7 CA7 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
780 Retinoic acid receptor RXR-gamma RXRG 0.001
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
369 Coagulation factor VII F7 0.001
172 Potassium channel subfamily K member 1 KCNK1 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
3937 Fatty-acid amide hydrolase FAAH 0.001
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.001
345 Plasma retinol-binding protein RBP4 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
88 Retinoic acid receptor RXR-beta RXRB 0.0009
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0009
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0009
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0009
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0009
260 Cytochrome P450 51 ERG11 0.0009
761 Cytochrome P450 51 ERG11 0.0009
3163 Cytochrome P450 51 cyp51 0.0009
3957 Adenosine deaminase ADA 0.0009
162 Retinoic acid receptor gamma-1 RARG 0.0009
904 Glutathione S-transferase P GSTP1 0.0009
469 Annexin A1 ANXA1 0.0009
6020 Aldehyde oxidase AOX1 0.0009
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0008
592 Carbonic anhydrase 4 CA4 0.0008
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0008
737 Mineralocorticoid receptor NR3C2 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0008
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0008
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0008
239 Coagulation factor X F10 0.0008
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0008
614 Progesterone receptor PGR 0.0007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0007
6085 Fatty acid-binding protein, intestinal FABP2 0.0007
2981 Phospholipase A2, membrane associated PLA2G2A 0.0007
275 Arachidonate 5-lipoxygenase ALOX5 0.0007
4604 Liver carboxylesterase 1 CES1 0.0006
54 Prothrombin F2 0.0006
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0006
357 Carbonic anhydrase 2 CA2 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
7 Nitric oxide synthase, inducible NOS2 0.0006
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0005
3939 Amine oxidase [flavin-containing] B MAOB 0.0005
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0005
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0005
921 Glutamate receptor 2 GRIA2 0.0005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0005
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