DT-Web: DB01173

Identification

Name

Orphenadrine

Accession Number

DB01173 (APRD00097)

Type

small molecule

Description

A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

269.3813

Groups

approved

Monoisotopic Weight

269.177964363

Pharmacology

Indication

Indicated for the treatment of Parkinson's disease.

Mechanism of action

Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect.

Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Protein binding

95%

Biotransformation

Biotransformation occurs mainly in the liver. Pharmacologically active metabolites are N-demethyl orphenadrine and N,N-didemethyl orphenadrine.

Route of elimination

Not Available

Toxicity

Oral, mouse LD₅₀ = 100 mg/kg; oral, rat LD₅₀ = 255 mg/kg

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Docetaxel	Orphenadrine may increase the serum levels and toxicity of docetaxel.
Donepezil	Possible antagonism of action
Galantamine	Possible antagonism of action
Haloperidol	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Rivastigmine	Possible antagonism of action
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Orphenadrine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Trimethobenzamide	Trimethobenzamide and Orphenadrine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine	Triprolidine and Orphenadrine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium	Trospium and Orphenadrine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.

Food Interactions

Take without regard to meals. Avoid alcohol.

Glutamate [NMDA] receptor subunit epsilon-4
Name	Glutamate [NMDA] receptor subunit epsilon-4
Gene Name	GRIN2D
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Kornhuber J, Parsons CG, Hartmann S, Retz W, Kamolz S, Thome J, Riederer P: Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995;102(3):237-46. - Pubmed
DTHybrid score	0.2674
Glutamate [NMDA] receptor subunit zeta-1
Name	Glutamate [NMDA] receptor subunit zeta-1
Gene Name	GRIN1
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Kornhuber J, Parsons CG, Hartmann S, Retz W, Kamolz S, Thome J, Riederer P: Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995;102(3):237-46. - Pubmed
DTHybrid score	0.7059
Glutamate [NMDA] receptor subunit 3B
Name	Glutamate [NMDA] receptor subunit 3B
Gene Name	GRIN3B
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Kornhuber J, Parsons CG, Hartmann S, Retz W, Kamolz S, Thome J, Riederer P: Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995;102(3):237-46. - Pubmed
DTHybrid score	0.2271
Glutamate [NMDA] receptor subunit 3A
Name	Glutamate [NMDA] receptor subunit 3A
Gene Name	GRIN3A
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Kornhuber J, Parsons CG, Hartmann S, Retz W, Kamolz S, Thome J, Riederer P: Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995;102(3):237-46. - Pubmed
DTHybrid score	0.391
Histamine H1 receptor
Name	Histamine H1 receptor
Gene Name	HRH1
Pharmacological action	yes
Actions	antagonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Rumore MM, Schlichting DA: Analgesic effects of antihistaminics. Life Sci. 1985 Feb 4;36(5):403-16. - Pubmed
DTHybrid score	0.5686
Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	yes
Actions	inhibitor
References	Pubill D, Canudas AM, Pallas M, Sureda FX, Escubedo E, Camins A, Camarasa J: Assessment of the adrenergic effects of orphenadrine in rat vas deferens. J Pharm Pharmacol. 1999 Mar;51(3):307-12. - Pubmed
DTHybrid score	0.4452
Sodium channel protein type 10 subunit alpha
Name	Sodium channel protein type 10 subunit alpha
Gene Name	SCN10A
Pharmacological action	unknown
Actions	inhibitor
References	Pubill D, Canudas AM, Pallas M, Sureda FX, Escubedo E, Camins A, Camarasa J: Assessment of the adrenergic effects of orphenadrine in rat vas deferens. J Pharm Pharmacol. 1999 Mar;51(3):307-12. - Pubmed
DTHybrid score	0.6899

Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inhibitor,inducer
References	Peng FC, Lin Wu SW: Metabolism of territrem a in liver microsomes from male wistar rats: 3. Cytochrome p-450 isoforms catalyzing tra metabolism. J Toxicol Environ Health A. 2002 Dec 27;65(24):2163-75. - Pubmed Lin Wu SW, Jean WC, Peng FC, Edwards RJ: Cytochrome P-4503A1 catalyzes the formation of MA1 from territrem a in liver microsomes of 7-week-old female Wistar rats. J Toxicol Environ Health A. 2003 Mar 14;66(5):453-67. - Pubmed Chang TK, Weber GF, Crespi CL, Waxman DJ: Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Res. 1993 Dec 1;53(23):5629-37. - Pubmed Stresser DM, Dehal SS, Kupfer D: Ring hydroxylation of [o-3H]methoxychlor as a probe for liver microsomal CYP2B activity: potential for in vivo CYP2B assay. Anal Biochem. 1996 Jan 1;233(1):100-7. - Pubmed Murray M, Fiala-Beer E, Sutton D: Upregulation of cytochromes P450 2B in rat liver by orphenadrine. Br J Pharmacol. 2003 Jun;139(4):787-96. - Pubmed
DTHybrid score	0.3646
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Roos PH, Mahnke A: Metabolite complex formation of orphenadrine with cytochrome P450. Involvement of CYP2C11 and CYP3A isozymes. Biochem Pharmacol. 1996 Jul 12;52(1):73-84. - Pubmed
DTHybrid score	0.5419
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	Not Available
References	- Sai Y, Dai R, Yang TJ, Krausz KW, Gonzalez FJ, Gelboin HV, Shou M: Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450. Xenobiotica. 2000 Apr;30(4):327-43. - Pubmed
DTHybrid score	0.2928

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.304
6016	Cytochrome P450 2C19	CYP2C19	0.203
824	Sodium-dependent serotonin transporter	SLC6A4	0.2013
4200	Cytochrome P450 1A2	CYP1A2	0.2012
4757	Cytochrome P450 2C9	CYP2C9	0.19
713	Sodium-dependent dopamine transporter	SLC6A3	0.1799
1588	Multidrug resistance protein 1	ABCB1	0.1713
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.1679
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.1558
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.1502
4924	Cytochrome P450 2C8	CYP2C8	0.1284
4118	Cytochrome P450 3A5	CYP3A5	0.1152
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.1083
3923	Cholinesterase	BCHE	0.1015
556	Alpha-1A adrenergic receptor	ADRA1A	0.0891
6107	Cytochrome P450 3A7	CYP3A7	0.0885
5718	Cytochrome P450 2A6	CYP2A6	0.0879
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0802
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0761
831	D(2) dopamine receptor	DRD2	0.0705
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0685
6024	Cytochrome P450 1A1	CYP1A1	0.0675
587	Serum albumin	ALB	0.0648
482	Glycine receptor subunit alpha-1	GLRA1	0.0643
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0634
1181	Alpha-1-acid glycoprotein 1	ORM1	0.062
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0605
5469	Head decoration protein	shp	0.0562
6144	Solute carrier family 22 member 2	SLC22A2	0.0504
318	Alpha-2A adrenergic receptor	ADRA2A	0.05
51	Muscarinic acetylcholine receptor M3	CHRM3	0.049
696	Kappa-type opioid receptor	OPRK1	0.0455
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0453
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0449
6145	Solute carrier family 22 member 1	SLC22A1	0.0416
174	Sigma 1-type opioid receptor	SIGMAR1	0.0416
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0398
632	Alpha-1B adrenergic receptor	ADRA1B	0.0396
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0383
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0381
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0373
6106	Cytochrome P450 2C18	CYP2C18	0.0368
6151	Monocarboxylate transporter 10	SLC16A10	0.0365
20	Prostaglandin G/H synthase 1	PTGS1	0.0362
378	Alpha-2C adrenergic receptor	ADRA2C	0.0356
3811	Cytochrome P450 19A1	CYP19A1	0.0348
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.034
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0337
465	Calmodulin	CALM1	0.0332
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0306
6147	Solute carrier family 22 member 3	SLC22A3	0.0306
4604	Liver carboxylesterase 1	CES1	0.0291
3939	Amine oxidase [flavin-containing] B	MAOB	0.0287
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0276
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0274
131	Synaptic vesicular amine transporter	SLC18A2	0.0274
3941	Amine oxidase [flavin-containing] A	MAOA	0.0268
23	D(1A) dopamine receptor	DRD1	0.0265
6070	Nischarin	NISCH	0.0261
916	Metabotropic glutamate receptor 1	GRM1	0.0261
847	Mu-type opioid receptor	OPRM1	0.0257
629	Alpha-2B adrenergic receptor	ADRA2B	0.0246
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0242
467	Delta-type opioid receptor	OPRD1	0.0242
789	Alpha-1D adrenergic receptor	ADRA1D	0.024
118	Organic cation/carnitine transporter 2	SLC22A5	0.0238
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.023
537	ATP synthase delta chain, mitochondrial	ATP5D	0.023
705	Glutamate receptor 1	GRIA1	0.0218
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0218
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0214
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0209
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0204
260	Cytochrome P450 51	ERG11	0.0202
761	Cytochrome P450 51	ERG11	0.0202
3163	Cytochrome P450 51	cyp51	0.0202
2178	Metabotropic glutamate receptor 5	GRM5	0.0201
862	Multidrug resistance-associated protein 1	ABCC1	0.0198
468	Cytochrome P450 4A11	CYP4A11	0.0196
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0196
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0195
1268	Neuropeptide S receptor	NPSR1	0.0195
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0195
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0195
1729	Solute carrier family 22 member 6	SLC22A6	0.0181
1341	Histamine H3 receptor	HRH3	0.0181
136	Estrogen receptor	ESR1	0.018
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0178
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0177
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0175
4096	Metabotropic glutamate receptor 3	GRM3	0.0174
1362	Metabotropic glutamate receptor 2	GRM2	0.0174
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0172
871	Glucocorticoid receptor	NR3C1	0.0172
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0171
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0171
1898	Cytochrome P450 1B1	CYP1B1	0.017
6073	Potassium channel subfamily K member 9	KCNK9	0.0169
6072	Potassium channel subfamily K member 3	KCNK3	0.0169
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0168
516	Neurotensin receptor type 2	NTSR2	0.0168
638	D(3) dopamine receptor	DRD3	0.0164
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0163
1656	CYP2B protein	CYP2B	0.0163
766	Beta-2 adrenergic receptor	ADRB2	0.0158
833	Organic cation/carnitine transporter 1	SLC22A4	0.0154
776	Bile salt export pump	ABCB11	0.0154
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0151
922	Glutamate receptor 4	GRIA4	0.0148
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0148
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0148
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0148
4018	Glutamate receptor delta-2 subunit	GRID2	0.0148
4027	Glutamate receptor delta-1 subunit	GRID1	0.0148
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0148
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0148
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0148
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0148
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0148
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0148
4016	Excitatory amino acid transporter 5	SLC1A7	0.0148
4026	Aspartyl aminopeptidase	DNPEP	0.0148
1912	Excitatory amino acid transporter 1	SLC1A3	0.0148
664	Glutamate decarboxylase 2	GAD2	0.0148
3890	Glutamate decarboxylase 2	GAD2	0.0148
4019	Excitatory amino acid transporter 4	SLC1A6	0.0148
925	Metabotropic glutamate receptor 4	GRM4	0.0148
1047	Excitatory amino acid transporter 2	SLC1A2	0.0148
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0148
4017	5-oxoprolinase	OPLAH	0.0148
4020	Glutamyl aminopeptidase	ENPEP	0.0148
926	Metabotropic glutamate receptor 7	GRM7	0.0148
927	Metabotropic glutamate receptor 8	GRM8	0.0148
731	HIV-1 protease	HIV-1 protease	0.0147
193	Beta-1 adrenergic receptor	ADRB1	0.0146
432	D(4) dopamine receptor	DRD4	0.0145
290	Prostaglandin G/H synthase 2	PTGS2	0.0144
6182	Cytochrome P450 2J2	CYP2J2	0.0141
820	Glycine receptor subunit alpha-2	GLRA2	0.0139
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0138
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0136
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0136
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0135
427	Substance-P receptor	TACR1	0.0135
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0134
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0131
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.013
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.013
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0128
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0128
716	5-hydroxytryptamine 7 receptor	HTR7	0.0128
625	Glutamate carboxypeptidase 2	FOLH1	0.0126
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0126
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0126
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0126
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0126
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0126
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0126
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0126
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0126
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0126
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0125
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0125
3904	Alanine aminotransferase 2	GPT2	0.0123
735	Alanine aminotransferase 1	GPT	0.0123
665	Phosphoserine aminotransferase	PSAT1	0.0122
4652	Phosphoserine aminotransferase	serC	0.0122
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0122
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0122
420	Glutamate decarboxylase 1	GAD1	0.0122
3900	Glutamate decarboxylase 1	GAD1	0.0122
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0122
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0121
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0121
694	Matrix protein 2	M	0.0121
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0121
2207	Rhodopsin	RHO	0.012
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
921	Glutamate receptor 2	GRIA2	0.0118
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0118
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0117
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0117
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0115
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0115
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0114
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0114
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0113
1671	Excitatory amino acid transporter 3	SLC1A1	0.0113
923	Glutamate receptor 3	GRIA3	0.0112
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0112
3877	Growth-inhibiting protein 18	GIG18	0.0112
122	P2Y purinoceptor 12	P2RY12	0.011
251	Alcohol dehydrogenase 1A	ADH1A	0.011
763	Tyrosine aminotransferase	TAT	0.0109
5493	Tyrosine aminotransferase	Not Available	0.0109
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0109
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0108
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0107
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0107
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0106
444	Alcohol dehydrogenase 1B	ADH1B	0.0104
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0104
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0104
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0104
6031	Cytochrome P450 3A43	CYP3A43	0.0104
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0103
6432	Transporter	snf	0.0103
124	Histamine H2 receptor	HRH2	0.0103
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0103
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0102
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0102
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0101
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.01
3426	Glutamine synthetase	glnA	0.01
3987	Glutamine synthetase	GLUL	0.01
319	Opioid receptor, sigma 1	OPRS1	0.0098
1275	Estrogen sulfotransferase	SULT1E1	0.0098
33	Cystine/glutamate transporter	SLC7A11	0.0097
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0096
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0096
1757	Myeloperoxidase	MPO	0.0095
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0094
2164	Multidrug resistance-associated protein 4	ABCC4	0.0094
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0094
4061	Peroxisomal sarcosine oxidase	PIPOX	0.0093
4057	Glycine N-acyltransferase	GLYAT	0.0093
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.0093
4056	N-arachidonyl glycine receptor	GPR18	0.0093
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.0093
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.0093
1466	Glycyl-tRNA synthetase	GARS	0.0093
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.0093
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.0093
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.0093
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.0093
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0092
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0092
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0092
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0091
818	50S ribosomal protein L10	rplJ	0.009
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.009
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0089
1636	Trace amine-associated receptor 1	TAAR1	0.0088
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0088
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0088
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0088
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0088
738	Monocarboxylate transporter 1	SLC16A1	0.0088
411	Glycine N-methyltransferase	GNMT	0.0088
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0087
811	Translocator protein	TSPO	0.0087
6142	Solute carrier family 22 member 8	SLC22A8	0.0087
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0087
844	Epidermal growth factor receptor	EGFR	0.0086
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0085
517	Alcohol dehydrogenase 1C	ADH1C	0.0084
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0084
16	Adenosine A1 receptor	ADORA1	0.0082
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0082
1517	Beta-3 adrenergic receptor	ADRB3	0.0081
232	Corticosteroid-binding globulin	SERPINA6	0.008
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.008
6220	Aryl hydrocarbon receptor	AHR	0.008
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0079
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
474	Acetylcholinesterase	ACHE	0.0078
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0078
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0076
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0076
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0076
1010	Cytochrome P450 51A1	CYP51A1	0.0075
62	Glycine receptor subunit beta	GLRB	0.0075
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0075
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0074
613	Atrial natriuretic peptide receptor A	NPR1	0.0074
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.007
461	Glycine receptor subunit alpha-3	GLRA3	0.007
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.007
3884	SHMT2 protein	SHMT2	0.007
3901	SHMT2 protein	SHMT2	0.007
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.007
3879	Serine hydroxymethyltransferase 2	Not Available	0.007
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.007
29	Tubulin beta-1 chain	TUBB1	0.0069
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0069
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0069
4120	NADPH--cytochrome P450 reductase	POR	0.0068
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0068
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0067
817	DNA topoisomerase 2-alpha	TOP2A	0.0066
207	Glutathione synthetase	GSS	0.0066
5269	Glutathione synthetase	gshB	0.0066
383	Glycine amidinotransferase, mitochondrial	GATM	0.0064
3947	Xanthine dehydrogenase/oxidase	XDH	0.0064
777	Tumor necrosis factor	TNF	0.0064
891	Dihydropteroate synthase	folP	0.0063
5359	Dihydropteroate synthase	folP	0.0063
7175	Dihydropteroate synthase	sulI	0.0063
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0063
6143	Solute carrier family 22 member 7	SLC22A7	0.0063
161	Tubulin beta chain	TUBB	0.0062
312	Tubulin beta chain	TUB2	0.0062
614	Progesterone receptor	PGR	0.0062
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0062
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0061
146	Androgen receptor	AR	0.0061
6102	Arylamine N-acetyltransferase 2	NAT2	0.006
6097	Protein S100-A2	S100A2	0.006
1810	Protein S100-A1	S100A1	0.006
869	Estrogen receptor beta	ESR2	0.006
349	Serine--pyruvate aminotransferase	AGXT	0.006
163	D(1B) dopamine receptor	DRD5	0.006
1178	Adenosine A2a receptor	ADORA2A	0.006
6020	Aldehyde oxidase	AOX1	0.006
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0058
3932	Glutathione S-transferase A2	GSTA2	0.0058
904	Glutathione S-transferase P	GSTP1	0.0057
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0057
6014	Cytochrome P450 2A13	CYP2A13	0.0056
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0056
6136	Multidrug resistance-associated protein 5	ABCC5	0.0055
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0054
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0053
6138	Multidrug resistance protein 3	ABCB4	0.0053
6137	Multidrug resistance-associated protein 6	ABCC6	0.0052
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0052
756	Sex hormone-binding globulin	SHBG	0.0052
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0052
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0052
94	5-hydroxytryptamine 4 receptor	HTR4	0.0052
1048	Protein S100-A13	S100A13	0.0052
2226	Protein S100-A12	S100A12	0.0052
592	Carbonic anhydrase 4	CA4	0.0052
295	Carbonic anhydrase 1	CA1	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
504	Mast/stem cell growth factor receptor	KIT	0.0051
6148	Multidrug resistance-associated protein 7	ABCC10	0.0051
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
2132	Protein S100-B	S100B	0.0049
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0048
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0047
828	Phenylalanine-4-hydroxylase	PAH	0.0047
3109	Phenylalanine-4-hydroxylase	phhA	0.0047
723	Cytosolic phospholipase A2	PLA2G4A	0.0047
1618	High affinity nerve growth factor receptor	NTRK1	0.0046
4122	Histone deacetylase 2	HDAC2	0.0046
856	Vitamin D3 receptor	VDR	0.0046
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0046
2230	Catalase	CAT	0.0045
3249	Catalase	katA	0.0045
3625	Catalase	katA	0.0045
4539	Catalase	katA	0.0045
4941	Catalase	katB	0.0045
814	Ryanodine receptor 1	RYR1	0.0045
952	Dipeptidyl peptidase 4	DPP4	0.0045
790	DNA polymerase subunit alpha B	POLA2	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
563	Thyroid peroxidase	TPO	0.0044
4116	Dihydropteroate synthetase	Not Available	0.0044
164	Histamine H4 receptor	HRH4	0.0043
1024	Solute carrier family 22 member 11	SLC22A11	0.0043
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0042
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0042
284	DNA-directed RNA polymerase beta chain	rpoB	0.0042
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0042
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0039
357	Carbonic anhydrase 2	CA2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0038
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0038
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0038
1483	Membrane copper amine oxidase	AOC3	0.0038
153	Dopamine beta-hydroxylase	DBH	0.0037
407	Vascular endothelial growth factor receptor 2	KDR	0.0037
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0037
390	Adenosine A3 receptor	ADORA3	0.0037
6126	Carbonic anhydrase 7	CA7	0.0036
373	Transthyretin	TTR	0.0036
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
6141	Sodium/bile acid cotransporter	SLC10A1	0.0036
3404	Exotoxin A	eta	0.0036
3937	Fatty-acid amide hydrolase	FAAH	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0034
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0034
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0034
26	Vascular endothelial growth factor receptor 3	FLT4	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0033
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0033
3810	Catechol O-methyltransferase	COMT	0.0033
32	Vascular endothelial growth factor receptor 1	FLT1	0.0032
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0032
6766	O-GlcNAcase BT_4395	BT_4395	0.0031
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0031
473	L-lactate dehydrogenase A chain	LDHA	0.0031
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0031
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
228	Beta platelet-derived growth factor receptor	PDGFRB	0.003
84	Nuclear receptor 0B1	NR0B1	0.003
1192	Sulfotransferase 1A1	SULT1A1	0.003
6043	Putative G-protein coupled receptor 44	GPR44	0.003
581	Cytochrome P450 2R1	CYP2R1	0.003
4203	Histamine N-methyltransferase	HNMT	0.003
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0029
823	Fibroblast growth factor receptor 2	FGFR2	0.0029
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0029
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0029
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0029
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0029
518	Peroxidase/catalase T	katG	0.0029
2290	ADP-ribosyl cyclase 2	BST1	0.0028
7	Nitric oxide synthase, inducible	NOS2	0.0028
2298	Cytochrome P450-cam	camC	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0028
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0028
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
908	Glutathione S-transferase theta-1	GSTT1	0.0027
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0027
380	Cytochrome P450 17A1	CYP17A1	0.0027
365	Dihydrofolate reductase	DHFR	0.0027
2381	Dihydrofolate reductase	DFR1	0.0027
2833	Dihydrofolate reductase	Not Available	0.0027
2931	Dihydrofolate reductase	folA	0.0027
3544	Dihydrofolate reductase	folA	0.0027
3682	Dihydrofolate reductase	folA	0.0027
6642	Dihydrofolate reductase	folA	0.0027
6756	Dihydrofolate reductase	dfrA	0.0027
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0027
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0027
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0026
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0026
275	Arachidonate 5-lipoxygenase	ALOX5	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
3809	Estrogen-related receptor gamma	ESRRG	0.0026
1050	Bile salt sulfotransferase	SULT2A1	0.0026
49	Endothelin B receptor	EDNRB	0.0026
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0025
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0025
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
358	Cystathionine beta-synthase	CBS	0.0025
578	Endothelin-1 receptor	EDNRA	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
1353	DNA topoisomerase 1	TOP1	0.0023
3552	DNA topoisomerase 1	topA	0.0023
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0023
70	Type-1 angiotensin II receptor	AGTR1	0.0023
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0023
1262	Corticotropin-lipotropin	POMC	0.0023
737	Mineralocorticoid receptor	NR3C2	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
896	Glutathione S-transferase Mu 1	GSTM1	0.0022
65	Matrix metalloproteinase-9	Not Available	0.0021
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0021
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0021
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0021
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0021
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0021
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0021
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0021
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0021
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0021
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0021
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0021
469	Annexin A1	ANXA1	0.0021
3601	Dihydropteroate synthase 1	folP1	0.0021
3807	Dihydropteroate synthase 1	folP1	0.0021
3808	Dihydropteroate synthase 2	folP2	0.0021
780	Retinoic acid receptor RXR-gamma	RXRG	0.002
6146	High affinity copper uptake protein 1	SLC31A1	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
6085	Fatty acid-binding protein, intestinal	FABP2	0.002
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.002
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.002
3917	Methylenetetrahydrofolate reductase	MTHFR	0.002
751	Potassium channel subfamily K member 6	KCNK6	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
3913	Glutamic acid decarboxylase	GAD65	0.0019
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0019
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0019
6131	Carbonic anhydrase 14	CA14	0.0019
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0019
183	Vascular endothelial growth factor A	VEGFA	0.0019
88	Retinoic acid receptor RXR-beta	RXRB	0.0019
5787	Angiopoietin-1 receptor	TEK	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
1992	Vitamin D-binding protein	GC	0.0019
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
172	Potassium channel subfamily K member 1	KCNK1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0018
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
683	Potassium transporter	GK0582	0.0018
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0018
6122	Carbonic anhydrase 3	CA3	0.0018
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
239	Coagulation factor X	F10	0.0017
291	Nitric-oxide synthase, endothelial	NOS3	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
6163	Copper-transporting ATPase 2	ATP7B	0.0017
6165	Copper-transporting ATPase 1	ATP7A	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
976	Platelet glycoprotein IX	GP9	0.0017
1630	Integrin beta-2	ITGB2	0.0017
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0017
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0017
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
293	Gamma-glutamyl hydrolase	GGH	0.0017
165	FL cytokine receptor	FLT3	0.0017
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0016
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0016
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0016
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0016
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0016
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3233	Bile acid receptor	NR1H4	0.0015
54	Prothrombin	F2	0.0015
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0015
1629	Transcription factor AP-1	JUN	0.0015
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0015
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0015
4311	tRNA	TRDMT1	0.0015
4325	tRNA	trmD	0.0015
4328	tRNA	trmD	0.0015
1650	Heme carrier protein 1	SLC46A1	0.0015
4192	DNA topoisomerase 2-beta	TOP2B	0.0015
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
634	Squalene monooxygenase	SQLE	0.0014
7196	Squalene monooxygenase	ERG1	0.0014
1541	Metalloproteinase	mmp20	0.0014
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0014
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0014
268	Adenosine A2b receptor	ADORA2B	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
936	Ephrin type-A receptor 2	EPHA2	0.0013
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0013
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
5798	Mitogen-activated protein kinase 11	MAPK11	0.0013
400	Coagulation factor IX	F9	0.0013
5461	Coagulation factor IX	F9	0.0013
569	Retinal dehydrogenase 2	ALDH1A2	0.0013
267	Plasminogen activator inhibitor 1	SERPINE1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
611	Retinal dehydrogenase 1	ALDH1A1	0.0012
1295	Fatty acid synthase	FASN	0.0012
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0012
604	Vitamin K-dependent protein Z	PROZ	0.0012
6221	Steroid hormone receptor ERR1	ESRRA	0.0012
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0012
605	Fumarate reductase flavoprotein subunit	frdA	0.0011
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0011
3673	Fumarate reductase flavoprotein subunit	fccA	0.0011
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0011
6549	Fumarate reductase flavoprotein subunit	frdA	0.0011
5934	Cytochrome P450 26A1	CYP26A1	0.0011
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
3221	Cytochrome c4	cc4	0.0011
2236	Casein kinase II subunit alpha	CSNK2A1	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
1039	Histone deacetylase 9	HDAC9	0.0011
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0011
422	Vitamin K-dependent protein C	PROC	0.0011
1245	Vitamin K-dependent protein S	PROS1	0.0011
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0011
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
3007	Carbonic anhydrase 12	CA12	0.001
4205	Carbonic anhydrase 9	CA9	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.001
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.001
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0009
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0009
3957	Adenosine deaminase	ADA	0.0009
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
162	Retinoic acid receptor gamma-1	RARG	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
6168	Solute carrier family 22 member 16	SLC22A16	0.0009
4773	Deoxycytidine kinase	DCK	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0009
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
798	Osteocalcin	BGLAP	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0008
6459	Glycodelin	PAEP	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
369	Coagulation factor VII	F7	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
76	Nitric-oxide synthase, brain	NOS1	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
2802	Endoglucanase G	celCCG	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
24	Thymidylate synthase	TMP1	0.0007
359	Thymidylate synthase	TYMS	0.0007
2626	Thymidylate synthase	thyA	0.0007
2729	Thymidylate synthase	thyA	0.0007
5352	Thymidylate synthase	THYA	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
125	DNA polymerase beta	POLB	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
273	Apoptosis regulator Bcl-2	BCL2	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
6149	Solute carrier family 22 member 10	SLC22A10	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4943	Cytochrome c6	petJ	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4909	CooA protein	cooA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
5000	HemO	hemO	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4935	Cytochrome c-554	cycA1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4972	P450cin	cinA	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4961	Hemophore HasA	hasA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
4952	Catalase/peroxidase	katA	0.0004
3093	Catalase HPII	katE	0.0004
4103	Proteasome subunit beta type 2	PSMB2	0.0004
4101	Proteasome subunit beta type 1	PSMB1	0.0004
4102	Proteasome subunit beta type 5	PSMB5	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
4217	Telomerase reverse transcriptase	TERT	0.0004
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
6044	Serum paraoxonase/lactonase 3	PON3	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
572	Integrin alpha-L	ITGAL	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0003
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0003
2320	Thymidine kinase, cytosolic	TK1	0.0003
4920	Peroxidase/catalase	katG	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4990	PpcA	ppcA	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
4037	Hypothetical protein	GPX1	0.0003
4297	Hypothetical protein	SP_1951	0.0003
4521	Hypothetical protein	BC_2969	0.0003
4540	Hypothetical protein	TM_1070	0.0003
4555	Hypothetical protein	MT1739	0.0003
4569	Hypothetical protein	mshD	0.0003
4578	Hypothetical protein	PA3270	0.0003
4747	Hypothetical protein	PA3967	0.0003
5177	Hypothetical protein	TM_0096	0.0003
5194	Hypothetical protein	PA1204	0.0003
5240	Hypothetical protein	Rv2991	0.0003
5370	Hypothetical protein	TM_1158	0.0003
5710	Hypothetical protein	Tb927.5.1360	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
1864	RET proto-oncogene	RET	0.0003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
6218	Pannexin-1	PANX1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0003
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0002
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
1507	Cytochrome c	CYCS	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
489	Monocarboxylate transporter 2	SLC16A7	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01173 - Orphenadrine

Targets

Enzymes

Predictions