DT-Web

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide


Partner ID 2379
Name Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide
Synonyms 4215
Gene name DAPP1
General function Involved in phosphoinositide 3-kinase regulator activity
Specific function May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K
Gene sequence + ...

ATGGGCAGAGCAGAACTTCTAGAAGGGAAGATGAGCACCCAGGATCCCTCAGATCTGTGGAGCAGATCCGATGGAGAGGCTGAGCTGCTCCAGGACTTGGGGTGGTATCACGGCAACCTCACACGCCATGCTGCTGAAGCTCTTCTCCTCTCAAATGGATGTGACGGCAGCTACCTTCTGAGGGACAGCAATGAGACCACCGGGCTGTACTCTCTCTCTGTGAGGGCCAAAGATTCTGTTAAACACTTTCATGTTGAATATACTGGATATTCATTTAAATTTGGCTTTAATGAATTCTCATCTTTGAAGGATTTTGTCAAGCATTTTGCAAATCAGCCTTTGATTGGAAGCGAGACAGGCACTCTGATGGTTCTAAAACATCCCTACCCAAGAAAAGTGGAAGAACCCTCCATTTATGAATCTGTCCGGGTTCACACAGCAATGCAGACAGGAAGAACAGAAGATGACCTTGTGCCCACAGCACCTTCTCTGGGCACCAAAGAAGGTTACCTCACCAAACAGGGAGGCCTGGTCAAGACCTGGAAAACAAGATGGTTTACTCTGCACAGGAATGAACTGAAATACTTCAAAGACCAGATGTCACCAGAACCAATTCGGATCCTAGACCTAACAGAATGTTCAGCTGTACAATTCGATTATTCACAAGAAAGGGTAAACTGTTTTTGTTTGGTATTTCCATTCAGGACATTTTATCTCTGTGCAAAGACCGGAGTAGAAGCTGATGAGTGGATCAAGATATTACGCTGGAAATTGTCACAAATAAGAAAACAGCTCAACCAAGGGGAAGGCACGATCCGATCTCGGTCGTTCATCTTTAAATAG
Protein sequence + ...

MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK
GO Classification
component
phosphoinositide 3-kinase complex
protein complex
function
lipid kinase activity
phosphoinositide 3-kinase activity
phosphatidylinositol 3-kinase activity
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
process
intracellular signaling cascade
cellular process
cell communication
signal transduction
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01863 Inositol 1,3,4,5-Tetrakisphosphate

Associated as Prediction

Id Name
DB00171 Adenosine triphosphate
DB00482 Celecoxib
DB01169 Arsenic trioxide
DB01863 Inositol 1,3,4,5-Tetrakisphosphate
DB01933 7-Hydroxystaurosporine
DB01942 Formic Acid
DB01946 3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione
DB02010 Staurosporine
DB03401 D-Myo-Inositol-1,4,5-Triphosphate
DB03431 Adenosine-5'-Diphosphate
DB03777 Rbt205 Inhibitor
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB04522 Phosphonoserine
DB04530 S,S-(2-Hydroxyethyl)Thiocysteine
DB06932 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
DB07033 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
DB07132 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
DB07300 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
DB07348 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE
DB07456 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
DB07457 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
DB07584 N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
DB07585 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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