DT-Web

DB01169 - Arsenic trioxide


Identification
Name Arsenic trioxide
Accession Number DB01169 (APRD00171)
Type small molecule
Description Arsenic trioxide is a chemotheraputic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. Due to the toxic nature of arsenic, this drug carries significant health risks. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 197.8414
Groups approved
Monoisotopic Weight 197.8279367
Pharmacology
Indication For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression
Mechanism of action The mechanism of action of Arsenic Trioxide is not completely understood. Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro. Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR-alpha. It is suspected that arsenic trioxide induces cancer cells to undergo apoptosis.
Absorption Not Available
Protein binding 75% bound
Biotransformation The metabolism of arsenic trioxide involves reduction of pentavalent arsenic to trivalent arsenic by arsenate reductase and methylation of trivalent arsenic to monomethylarsonic acid and monomethylarsonic acid to dimethylarsinic acid by methyltransferases. The main site of methylation reactions appears to be the liver. Arsenic is stored mainly in liver, kidney, heart, lung, hair and nails.
Route of elimination Trivalent arsenic is mostly methylated in humans and excreted in urine.
Toxicity Symptoms of overdose include convulsions, muscle weakness and confusion.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Quinupristin This combination presents an increased risk of toxicity
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telavancin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions Not Available

Targets


Inhibitor of nuclear factor kappa-B kinase subunit beta
Name Inhibitor of nuclear factor kappa-B kinase subunit beta
Gene Name IKBKB
Pharmacological action yes
Actions inducer
References
  • Ouyang W, Ma Q, Li J, Zhang D, Liu ZG, Rustgi AK, Huang C: Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes. Cancer Res. 2005 Oct 15;65(20):9287-93. - Pubmed
  • Ouyang W, Li J, Ma Q, Huang C: Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells. Carcinogenesis. 2006 Apr;27(4):864-73. Epub 2005 Dec 29. - Pubmed
  • Ouyang W, Zhang D, Ma Q, Li J, Huang C: Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells. Environ Health Perspect. 2007 Apr;115(4):513-8. Epub 2006 Dec 14. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4358
Thioredoxin reductase 1, cytoplasmic
Name Thioredoxin reductase 1, cytoplasmic
Gene Name TXNRD1
Pharmacological action yes
Actions inhibitor
References
  • Lu J, Chew EH, Holmgren A: Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12288-93. Epub 2007 Jul 18. - Pubmed
DTHybrid score 0.7059
Transcription factor AP-1
Name Transcription factor AP-1
Gene Name JUN
Pharmacological action yes
Actions inducer
References
  • Muscarella DE, Bloom SE: Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines. Toxicol Sci. 2002 Jul;68(1):82-92. - Pubmed
  • Dong Z: The molecular mechanisms of arsenic-induced cell transformation and apoptosis. Environ Health Perspect. 2002 Oct;110 Suppl 5:757-9. - Pubmed
  • Drobna Z, Jaspers I, Thomas DJ, Styblo M: Differential activation of AP-1 in human bladder epithelial cells by inorganic and methylated arsenicals. FASEB J. 2003 Jan;17(1):67-9. Epub 2002 Nov 15. - Pubmed
  • Li J, Gorospe M, Barnes J, Liu Y: Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. J Biol Chem. 2003 Apr 11;278(15):13183-91. Epub 2003 Jan 23. - Pubmed
  • Kietzmann T, Samoylenko A, Immenschuh S: Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. J Biol Chem. 2003 May 16;278(20):17927-36. Epub 2003 Mar 11. - Pubmed
DTHybrid score 0.3292
G1/S-specific cyclin-D1
Name G1/S-specific cyclin-D1
Gene Name CCND1
Pharmacological action yes
Actions antagonist
References
  • Hyun Park W, Hee Cho Y, Won Jung C, Oh Park J, Kim K, Hyuck Im Y, Lee MH, Ki Kang W, Park K: Arsenic trioxide inhibits the growth of A498 renal cell carcinoma cells via cell cycle arrest or apoptosis. Biochem Biophys Res Commun. 2003 Jan 3;300(1):230-5. - Pubmed
  • Ouyang W, Ma Q, Li J, Zhang D, Liu ZG, Rustgi AK, Huang C: Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes. Cancer Res. 2005 Oct 15;65(20):9287-93. - Pubmed
  • Ouyang W, Li J, Ma Q, Huang C: Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells. Carcinogenesis. 2006 Apr;27(4):864-73. Epub 2005 Dec 29. - Pubmed
  • Hwang BJ, Utti C, Steinberg M: Induction of cyclin D1 by submicromolar concentrations of arsenite in human epidermal keratinocytes. Toxicol Appl Pharmacol. 2006 Dec 1;217(2):161-7. Epub 2006 Aug 11. - Pubmed
  • Ouyang W, Li J, Zhang D, Jiang BH, Huang DC: PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1. J Cell Biochem. 2007 Jul 1;101(4):969-78. - Pubmed
DTHybrid score 0.3495
Mitogen-activated protein kinase 3
Name Mitogen-activated protein kinase 3
Gene Name MAPK3
Pharmacological action yes
Actions inducer
References
  • Fauconneau B, Petegnief V, Sanfeliu C, Piriou A, Planas AM: Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide-induced cell death. J Neurochem. 2002 Dec;83(6):1338-48. - Pubmed
  • Jung DK, Bae GU, Kim YK, Han SH, Choi WS, Kang H, Seo DW, Lee HY, Cho EJ, Lee HW, Han JW: Hydrogen peroxide mediates arsenite activation of p70(s6k) and extracellular signal-regulated kinase. Exp Cell Res. 2003 Oct 15;290(1):144-54. - Pubmed
  • Tanaka-Kagawa T, Hanioka N, Yoshida H, Jinno H, Ando M: Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes. Br J Dermatol. 2003 Dec;149(6):1116-27. - Pubmed
  • Felix K, Manna SK, Wise K, Barr J, Ramesh GT: Low levels of arsenite activates nuclear factor-kappaB and activator protein-1 in immortalized mesencephalic cells. J Biochem Mol Toxicol. 2005 Mar-Apr;19(2):67-77. - Pubmed
  • Mousa SA, O'Connor L, Rossman TG, Block E: Pro-angiogenesis action of arsenic and its reversal by selenium-derived compounds. Carcinogenesis. 2007 May;28(5):962-7. Epub 2006 Dec 8. - Pubmed
DTHybrid score 0.4874
Mitogen-activated protein kinase 1
Name Mitogen-activated protein kinase 1
Gene Name MAPK1
Pharmacological action yes
Actions inducer
References
  • Dong Z: The molecular mechanisms of arsenic-induced cell transformation and apoptosis. Environ Health Perspect. 2002 Oct;110 Suppl 5:757-9. - Pubmed
  • He Z, Ma WY, Liu G, Zhang Y, Bode AM, Dong Z: Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. J Biol Chem. 2003 Mar 21;278(12):10588-93. Epub 2003 Jan 14. - Pubmed
DTHybrid score 1.2001
RAC-alpha serine/threonine-protein kinase
Name RAC-alpha serine/threonine-protein kinase
Gene Name AKT1
Pharmacological action unknown
Actions inducer
References
  • Fauconneau B, Petegnief V, Sanfeliu C, Piriou A, Planas AM: Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide-induced cell death. J Neurochem. 2002 Dec;83(6):1338-48. - Pubmed
  • He Z, Ma WY, Liu G, Zhang Y, Bode AM, Dong Z: Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. J Biol Chem. 2003 Mar 21;278(12):10588-93. Epub 2003 Jan 14. - Pubmed
  • Ivanov VN, Hei TK: Combined treatment with EGFR inhibitors and arsenite upregulated apoptosis in human EGFR-positive melanomas: a role of suppression of the PI3K-AKT pathway. Oncogene. 2005 Jan 20;24(4):616-26. - Pubmed
  • Wang ZX, Jiang CS, Liu L, Wang XH, Jin HJ, Wu Q, Chen Q: The role of Akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation. Cell Res. 2005 May;15(5):379-86. - Pubmed
  • Tsou TC, Tsai FY, Hsieh YW, Li LA, Yeh SC, Chang LW: Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase. Toxicol Appl Pharmacol. 2005 Nov 1;208(3):277-84. - Pubmed
DTHybrid score 0.5966

Enzymes


Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3567
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.283
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5085

Transporters


Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inducer
References
  • Kauffmann HM, Pfannschmidt S, Zoller H, Benz A, Vorderstemann B, Webster JI, Schrenk D: Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46. - Pubmed
DTHybrid score 0.3229
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Hu XM, Hirano T, Oka K: Arsenic trioxide induces apoptosis equally in T lymphoblastoid leukemia MOLT-4 cells and P-gp-expressing daunorubicin-resistant MOLT-4 cells. Cancer Chemother Pharmacol. 2003 Feb;51(2):119-26. Epub 2002 Nov 20. - Pubmed
  • Wei HL, Yao XJ, Li YN, Wang P, Zhao HS, Bai DC, Peng X, Ma LF: [Arsenic trioxide inhibits P-glycoprotein expression in multidrug-resistant human leukemia K562/ADM cell line that overexpresses mdr-1 gene and enhances their chemotherapeutic sensitivity] Zhonghua Xue Ye Xue Za Zhi. 2003 Jan;24(1):28-31. - Pubmed
  • Wei H, Su H, Bai D, Zhao H, Ge J, Wang B, Yao X, Ma L: Arsenic trioxide inhibits p-glycoprotein expression in multidrug-resistant human leukemia cells that overexpress the MDR1 gene. Chin Med J (Engl). 2003 Nov;116(11):1644-8. - Pubmed
  • Kimura A, Ishida Y, Wada T, Yokoyama H, Mukaida N, Kondo T: MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice. Toxicol Appl Pharmacol. 2005 Feb 15;203(1):53-61. - Pubmed
  • Cronin CJ, Mendel JE, Mukhtar S, Kim YM, Stirbl RC, Bruck J, Sternberg PW: An automated system for measuring parameters of nematode sinusoidal movement. BMC Genet. 2005 Feb 7;6(1):5. - Pubmed
DTHybrid score 0.4416

Predictions


Id Partner name Gene Name Score
1721 Glycogen synthase kinase-3 beta GSK3B 0.2173
4200 Cytochrome P450 1A2 CYP1A2 0.2107
4119 Cytochrome P450 2D6 CYP2D6 0.188
4118 Cytochrome P450 3A5 CYP3A5 0.1636
4757 Cytochrome P450 2C9 CYP2C9 0.1593
4924 Cytochrome P450 2C8 CYP2C8 0.1475
6016 Cytochrome P450 2C19 CYP2C19 0.1265
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1229
5716 Casein kinase I isoform gamma-2 CSNK1G2 0.1225
6296 Serine/threonine-protein kinase haspin GSG2 0.1143
587 Serum albumin ALB 0.114
20 Prostaglandin G/H synthase 1 PTGS1 0.1051
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.1013
6107 Cytochrome P450 3A7 CYP3A7 0.0994
3959 Cell division protein kinase 4 CDK4 0.0942
6013 Cytochrome P450 2E1 CYP2E1 0.0902
1540 Mitogen-activated protein kinase 14 MAPK14 0.09
6030 Cytochrome P450 2B6 CYP2B6 0.0878
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0863
862 Multidrug resistance-associated protein 1 ABCC1 0.0843
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.081
290 Prostaglandin G/H synthase 2 PTGS2 0.0787
776 Bile salt export pump ABCB11 0.0774
3560 Gentamicin 3'-acetyltransferase aacC1 0.0751
275 Arachidonate 5-lipoxygenase ALOX5 0.0658
1372 Insulin receptor substrate 1 IRS1 0.065
6145 Solute carrier family 22 member 1 SLC22A1 0.0626
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0594
5718 Cytochrome P450 2A6 CYP2A6 0.0584
2379 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide DAPP1 0.0569
2348 Pleckstrin homology domain-containing family A member 4 PLEKHA4 0.0569
2355 Tyrosine-protein kinase BTK BTK 0.0568
2240 Cell division protein kinase 2 CDK2 0.0566
2826 Glucose--fructose oxidoreductase gfo 0.0557
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0557
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0557
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0556
1836 Mitogen-activated protein kinase 10 MAPK10 0.0554
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0549
2675 Pteridine reductase 1 PTR1 0.0545
70 Type-1 angiotensin II receptor AGTR1 0.0527
6144 Solute carrier family 22 member 2 SLC22A2 0.0504
1729 Solute carrier family 22 member 6 SLC22A6 0.0488
833 Organic cation/carnitine transporter 1 SLC22A4 0.0472
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0467
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0461
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0458
1757 Myeloperoxidase MPO 0.0451
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.043
36 Insulin receptor INSR 0.0421
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0419
4534 Cytohesin-2 CYTH2 0.041
6210 Tubulin delta chain TUBD1 0.0409
6212 Tubulin gamma-1 chain TUBG1 0.0409
6211 Tubulin epsilon chain TUBE1 0.0409
136 Estrogen receptor ESR1 0.0408
6137 Multidrug resistance-associated protein 6 ABCC6 0.0407
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0401
6043 Putative G-protein coupled receptor 44 GPR44 0.039
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0386
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0372
2449 Tubulin alpha-3 chain TUBA1A 0.0369
3947 Xanthine dehydrogenase/oxidase XDH 0.0359
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0346
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0344
3811 Cytochrome P450 19A1 CYP19A1 0.0343
161 Tubulin beta chain TUBB 0.0333
312 Tubulin beta chain TUB2 0.0333
871 Glucocorticoid receptor NR3C1 0.0333
817 DNA topoisomerase 2-alpha TOP2A 0.0328
6148 Multidrug resistance-associated protein 7 ABCC10 0.0315
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0314
2164 Multidrug resistance-associated protein 4 ABCC4 0.03
6106 Cytochrome P450 2C18 CYP2C18 0.0293
33 Cystine/glutamate transporter SLC7A11 0.0292
468 Cytochrome P450 4A11 CYP4A11 0.0287
1650 Heme carrier protein 1 SLC46A1 0.0284
193 Beta-1 adrenergic receptor ADRB1 0.028
1742 D-HSCDK2 CDK2deltaT 0.0274
1771 Cell division control protein 2 homolog CDK1 0.0274
3321 Cell division control protein 2 homolog CRK2 0.0274
6142 Solute carrier family 22 member 8 SLC22A8 0.0273
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0271
1058 Cell division protein kinase 5 CDK5 0.0266
118 Organic cation/carnitine transporter 2 SLC22A5 0.0262
766 Beta-2 adrenergic receptor ADRB2 0.0257
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0253
822 Aldose reductase AKR1B1 0.0244
492 Histamine H1 receptor HRH1 0.0244
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0243
6147 Solute carrier family 22 member 3 SLC22A3 0.0229
556 Alpha-1A adrenergic receptor ADRA1A 0.0227
6143 Solute carrier family 22 member 7 SLC22A7 0.0226
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0226
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0221
1517 Beta-3 adrenergic receptor ADRB3 0.0218
4750 Protein S100-A11 S100A11 0.0216
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0214
6141 Sodium/bile acid cotransporter SLC10A1 0.0214
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0212
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0212
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0212
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0206
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.02
824 Sodium-dependent serotonin transporter SLC6A4 0.0196
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0193
614 Progesterone receptor PGR 0.0192
831 D(2) dopamine receptor DRD2 0.019
3482 Cell division protein kinase 7 CDK7 0.0189
4751 Mitogen-activated protein kinase 12 MAPK12 0.0189
3005 Threonine-phosphate decarboxylase cobD 0.0188
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0184
477 DNA topoisomerase 4 subunit A parC 0.0184
886 DNA topoisomerase 4 subunit A parC 0.0184
6226 DNA topoisomerase 4 subunit A parC 0.0184
2530 Protein kinase C theta type PRKCQ 0.0181
404 DNA gyrase subunit A gyrA 0.0181
6224 DNA gyrase subunit A gyrA 0.0181
731 HIV-1 protease HIV-1 protease 0.0177
318 Alpha-2A adrenergic receptor ADRA2A 0.0174
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0174
502 5-hydroxytryptamine 2A receptor HTR2A 0.0167
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0164
4120 NADPH--cytochrome P450 reductase POR 0.016
146 Androgen receptor AR 0.0159
4228 Keratin, type II cytoskeletal 7 KRT7 0.0158
777 Tumor necrosis factor TNF 0.0156
260 Cytochrome P450 51 ERG11 0.0154
761 Cytochrome P450 51 ERG11 0.0154
3163 Cytochrome P450 51 cyp51 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0153
3923 Cholinesterase BCHE 0.0153
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0148
320 5-hydroxytryptamine 1A receptor HTR1A 0.0147
29 Tubulin beta-1 chain TUBB1 0.0146
1024 Solute carrier family 22 member 11 SLC22A11 0.0145
484 Tyrosine-protein kinase ABL2 ABL2 0.0144
844 Epidermal growth factor receptor EGFR 0.0143
4604 Liver carboxylesterase 1 CES1 0.0141
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.014
632 Alpha-1B adrenergic receptor ADRA1B 0.0139
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0137
1852 Microtubule-associated protein 2 MAP2 0.0137
1422 Serine/threonine-protein kinase 6 AURKA 0.0135
4203 Histamine N-methyltransferase HNMT 0.0134
6220 Aryl hydrocarbon receptor AHR 0.0134
847 Mu-type opioid receptor OPRM1 0.0132
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
51 Muscarinic acetylcholine receptor M3 CHRM3 0.013
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0129
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0129
2499 Tubulin beta-2C chain TUBB2C 0.0129
6014 Cytochrome P450 2A13 CYP2A13 0.0129
2207 Rhodopsin RHO 0.0129
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0129
322 Vasopressin V2 receptor AVPR2 0.0128
465 Calmodulin CALM1 0.0127
23 D(1A) dopamine receptor DRD1 0.0125
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0123
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0122
6031 Cytochrome P450 3A43 CYP3A43 0.0121
5923 Microtubule-associated protein tau MAPT 0.0121
5924 Microtubule-associated protein 4 MAP4 0.0121
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0121
504 Mast/stem cell growth factor receptor KIT 0.0121
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0121
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0118
340 Apoptotic protease-activating factor 1 APAF1 0.0117
48 Pyridoxal kinase PDXK 0.0116
1192 Sulfotransferase 1A1 SULT1A1 0.0115
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0114
467 Delta-type opioid receptor OPRD1 0.0113
590 5-hydroxytryptamine 2C receptor HTR2C 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0111
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0111
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0111
733 Activin receptor type 1B ACVR1B 0.0111
825 Arsenical pump-driving ATPase ASNA1 0.0111
3435 Arsenical pump-driving ATPase arsA 0.0111
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0111
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0111
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0111
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0111
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0111
154 AFG3-like protein 2 AFG3L2 0.0111
395 ALK tyrosine kinase receptor Not Available 0.0111
869 Estrogen receptor beta ESR2 0.0111
273 Apoptosis regulator Bcl-2 BCL2 0.011
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.011
228 Beta platelet-derived growth factor receptor PDGFRB 0.011
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0109
789 Alpha-1D adrenergic receptor ADRA1D 0.0109
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0109
380 Cytochrome P450 17A1 CYP17A1 0.0109
908 Glutathione S-transferase theta-1 GSTT1 0.0109
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0108
2443 Azurin azu 0.0108
737 Mineralocorticoid receptor NR3C2 0.0108
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0108
6146 High affinity copper uptake protein 1 SLC31A1 0.0107
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0107
6136 Multidrug resistance-associated protein 5 ABCC5 0.0107
341 5-hydroxytryptamine 3 receptor HTR3A 0.0106
1178 Adenosine A2a receptor ADORA2A 0.0106
292 Activin receptor type-1 ACVR1 0.0105
849 Activated CDC42 kinase 1 TNK2 0.0105
885 5-hydroxytryptamine 1B receptor HTR1B 0.0104
6182 Cytochrome P450 2J2 CYP2J2 0.0104
904 Glutathione S-transferase P GSTP1 0.0104
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0103
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0103
756 Sex hormone-binding globulin SHBG 0.0103
373 Transthyretin TTR 0.0101
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0101
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0099
629 Alpha-2B adrenergic receptor ADRA2B 0.0099
16 Adenosine A1 receptor ADORA1 0.0098
3941 Amine oxidase [flavin-containing] A MAOA 0.0098
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0096
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0096
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0096
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0096
297 Adenylate cyclase type 1 ADCY1 0.0096
696 Kappa-type opioid receptor OPRK1 0.0095
638 D(3) dopamine receptor DRD3 0.0095
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0093
6163 Copper-transporting ATPase 2 ATP7B 0.0092
814 Ryanodine receptor 1 RYR1 0.0092
6165 Copper-transporting ATPase 1 ATP7A 0.0092
725 5-hydroxytryptamine 1D receptor HTR1D 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.0091
122 P2Y purinoceptor 12 P2RY12 0.0091
613 Atrial natriuretic peptide receptor A NPR1 0.009
461 Glycine receptor subunit alpha-3 GLRA3 0.009
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0089
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0088
378 Alpha-2C adrenergic receptor ADRA2C 0.0088
896 Glutathione S-transferase Mu 1 GSTM1 0.0086
4192 DNA topoisomerase 2-beta TOP2B 0.0086
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0086
1010 Cytochrome P450 51A1 CYP51A1 0.0085
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0085
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0085
661 ADP/ATP translocase 1 SLC25A4 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
952 Dipeptidyl peptidase 4 DPP4 0.0084
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0082
24 Thymidylate synthase TMP1 0.0082
359 Thymidylate synthase TYMS 0.0082
2626 Thymidylate synthase thyA 0.0082
2729 Thymidylate synthase thyA 0.0082
5352 Thymidylate synthase THYA 0.0082
738 Monocarboxylate transporter 1 SLC16A1 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0081
6021 Adenosine kinase ADK 0.0081
3932 Glutathione S-transferase A2 GSTA2 0.008
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0078
26 Vascular endothelial growth factor receptor 3 FLT4 0.0077
1353 DNA topoisomerase 1 TOP1 0.0077
3552 DNA topoisomerase 1 topA 0.0077
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0077
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0075
740 Argininosuccinate synthase ASS1 0.0075
865 Argininosuccinate synthase ASS1 0.0075
2680 Argininosuccinate synthase argG 0.0075
3194 Argininosuccinate synthase argG 0.0075
407 Vascular endothelial growth factor receptor 2 KDR 0.0074
2236 Casein kinase II subunit alpha CSNK2A1 0.0074
32 Vascular endothelial growth factor receptor 1 FLT1 0.0074
3939 Amine oxidase [flavin-containing] B MAOB 0.0074
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0074
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0074
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0074
474 Acetylcholinesterase ACHE 0.0073
4122 Histone deacetylase 2 HDAC2 0.0071
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0071
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0071
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.007
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.007
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
68 Cannabinoid receptor 1 CNR1 0.007
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.007
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0069
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0069
713 Sodium-dependent dopamine transporter SLC6A3 0.0069
6085 Fatty acid-binding protein, intestinal FABP2 0.0068
244 Angiotensin-converting enzyme ACE 0.0068
436 5-hydroxytryptamine 2B receptor HTR2B 0.0068
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0067
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
716 5-hydroxytryptamine 7 receptor HTR7 0.0066
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0066
1063 Signal transducer and activator of transcription 5B STAT5B 0.0066
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0066
2808 Chloramphenicol acetyltransferase 3 cat3 0.0066
84 Nuclear receptor 0B1 NR0B1 0.0066
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0066
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0065
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0063
3830 Calreticulin CALR 0.0063
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0063
3270 Elongation factor G fusA 0.0062
124 Histamine H2 receptor HRH2 0.0062
4237 50S ribosomal protein L22 rplV 0.0062
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0061
936 Ephrin type-A receptor 2 EPHA2 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
469 Annexin A1 ANXA1 0.0059
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0059
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0059
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0059
571 Melatonin receptor type 1A MTNR1A 0.0059
362 Melatonin receptor type 1B MTNR1B 0.0059
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0058
6034 Hydroxyindole O-methyltransferase ASMT 0.0058
6035 Nuclear receptor ROR-beta RORB 0.0058
6036 Eosinophil peroxidase EPX 0.0058
790 DNA polymerase subunit alpha B POLA2 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0058
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0057
7 Nitric oxide synthase, inducible NOS2 0.0057
432 D(4) dopamine receptor DRD4 0.0057
2268 Cholesterol oxidase choB 0.0056
2822 Cholesterol oxidase choA 0.0056
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0056
6766 O-GlcNAcase BT_4395 BT_4395 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0056
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0055
5934 Cytochrome P450 26A1 CYP26A1 0.0055
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0055
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0055
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0055
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0055
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0055
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0054
5109 Outer membrane protein p64k or PM-6 m-6 0.0054
5122 Mersacidin decarboxylase mrsD 0.0054
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0054
5115 FkbI fkbI 0.0054
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0054
5095 Putidaredoxin reductase camA 0.0054
3763 5,10-methylenetetrahydrofolate reductase metF 0.0054
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0054
5094 5,10-methylenetetrahydrofolate reductase metF 0.0054
5083 Cryptochrome DASH cry 0.0054
526 Thioredoxin reductase trxB 0.0054
3767 Thioredoxin reductase trxB 0.0054
5078 Amine oxidase, flavin-containing PSPTO1126 0.0054
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0054
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0054
5111 Phenylacetone monooxygenase pamO 0.0054
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0054
3133 UDP-galactopyranose mutase glf 0.0054
5099 UDP-galactopyranose mutase glf 0.0054
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0054
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0054
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0054
5081 L-aspartate oxidase nadB 0.0054
1410 Oxidoreductase HSD17B6 0.0054
4725 Oxidoreductase Not Available 0.0054
5124 Oxidoreductase Not Available 0.0054
5626 Nucleoside diphosphate kinase B NME2 0.0054
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0054
76 Nitric-oxide synthase, brain NOS1 0.0053
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0053
165 FL cytokine receptor FLT3 0.0053
820 Glycine receptor subunit alpha-2 GLRA2 0.0053
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0053
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0053
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0052
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
268 Adenosine A2b receptor ADORA2B 0.0052
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0051
6020 Aldehyde oxidase AOX1 0.0051
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0051
765 Indoleamine 2,3-dioxygenase IDO1 0.005
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.005
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.005
4477 Dihydrolipoyl dehydrogenase lpdV 0.0049
5077 Dihydrolipoyl dehydrogenase Not Available 0.0049
5117 Dihydrolipoyl dehydrogenase lpd 0.0049
4486 Phenol 2-hydroxylase component B pheA2 0.0049
4439 Ferredoxin reductase bphA4 0.0049
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0049
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0049
856 Vitamin D3 receptor VDR 0.0049
131 Synaptic vesicular amine transporter SLC18A2 0.0048
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0048
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0048
2112 Toll-like receptor 9 TLR9 0.0048
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0047
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0047
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0047
5073 Ferredoxin--NADP reductase petH 0.0047
5076 Ferredoxin--NADP reductase fpr 0.0047
5119 Ferredoxin--NADP reductase petH 0.0047
5121 Ferredoxin--NADP reductase fpr 0.0047
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0047
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0047
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0047
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0047
3594 Deoxyribodipyrimidine photo-lyase phr 0.0047
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0047
5080 Deoxyribodipyrimidine photo-lyase phr 0.0047
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0047
2526 NADPH-ferredoxin reductase fprA fprA 0.0047
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0047
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0047
2470 Pyruvate oxidase pox5 0.0047
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0047
5072 N,N-dimethylglycine oxidase dmg 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0047
683 Potassium transporter GK0582 0.0047
295 Carbonic anhydrase 1 CA1 0.0046
2232 Interleukin-5 IL5 0.0045
1593 Mucin-2 MUC2 0.0045
3102 Flavohemoprotein hmp 0.0045
4969 Flavohemoprotein hmp 0.0045
4440 NADH peroxidase npr 0.0045
357 Carbonic anhydrase 2 CA2 0.0045
811 Translocator protein TSPO 0.0044
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0044
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0044
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0044
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0044
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0044
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0044
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0044
4103 Proteasome subunit beta type 2 PSMB2 0.0044
4102 Proteasome subunit beta type 5 PSMB5 0.0044
4101 Proteasome subunit beta type 1 PSMB1 0.0044
1820 Beta-nerve growth factor NGF 0.0044
5294 Nucleoside diphosphate kinase A NME1 0.0044
2893 Glycine oxidase thiO 0.0043
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0043
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0043
106 Cannabinoid receptor 2 CNR2 0.0043
6138 Multidrug resistance protein 3 ABCB4 0.0043
3957 Adenosine deaminase ADA 0.0042
528 5-hydroxytryptamine 1E receptor HTR1E 0.0042
284 DNA-directed RNA polymerase beta chain rpoB 0.0042
5773 DNA-directed RNA polymerase beta chain rpoB 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0042
6599 HTH-type transcriptional regulator ttgR ttgR 0.0041
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0041
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
2823 Trypanothione reductase TPR 0.0041
1656 CYP2B protein CYP2B 0.0041
2567 Thymidylate synthase thyX thyX 0.0041
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0041
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1256 5-hydroxytryptamine 6 receptor HTR6 0.0041
592 Carbonic anhydrase 4 CA4 0.004
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.004
6149 Solute carrier family 22 member 10 SLC22A10 0.004
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.004
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.004
3937 Fatty-acid amide hydrolase FAAH 0.004
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.004
327 Glutathione reductase gor 0.004
5110 Glutathione reductase GR2 0.004
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.004
1760 Aminopeptidase N ANPEP 0.0039
6843 Aminopeptidase N pepN 0.0039
3426 Glutamine synthetase glnA 0.0039
3987 Glutamine synthetase GLUL 0.0039
6168 Solute carrier family 22 member 16 SLC22A16 0.0039
2769 P-hydroxybenzoate hydroxylase pobA 0.0039
2809 P-hydroxybenzoate hydroxylase pobA 0.0039
6167 Organic solute transporter subunit beta OSTB 0.0039
6166 Organic solute transporter subunit alpha OSTA 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
126 D-lactate dehydrogenase dld 0.0039
3545 D-lactate dehydrogenase Not Available 0.0039
4510 D-lactate dehydrogenase ldhA 0.0039
117 Sterol O-acyltransferase 1 SOAT1 0.0038
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0038
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0038
1123 Eosinophil cationic protein RNASE3 0.0038
2380 Monomeric sarcosine oxidase soxA 0.0038
239 Coagulation factor X F10 0.0038
4311 tRNA TRDMT1 0.0037
4325 tRNA trmD 0.0037
4328 tRNA trmD 0.0037
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
2599 Tyrosine-protein kinase HCK HCK 0.0037
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0036
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0036
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0036
6645 D-amino-acid oxidase DAO 0.0036
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
4773 Deoxycytidine kinase DCK 0.0035
921 Glutamate receptor 2 GRIA2 0.0035
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
823 Fibroblast growth factor receptor 2 FGFR2 0.0034
714 Glutathione reductase, mitochondrial GSR 0.0034
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0034
581 Cytochrome P450 2R1 CYP2R1 0.0034
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0034
6102 Arylamine N-acetyltransferase 2 NAT2 0.0034
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0033
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
1050 Bile salt sulfotransferase SULT2A1 0.0033
2107 Microtubule-associated protein 1A MAP1A 0.0032
164 Histamine H4 receptor HRH4 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
702 UMP-CMP kinase CMPK1 0.0031
3809 Estrogen-related receptor gamma ESRRG 0.0031
780 Retinoic acid receptor RXR-gamma RXRG 0.0031
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0031
3917 Methylenetetrahydrofolate reductase MTHFR 0.0031
1630 Integrin beta-2 ITGB2 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
751 Potassium channel subfamily K member 6 KCNK6 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
365 Dihydrofolate reductase DHFR 0.003
2381 Dihydrofolate reductase DFR1 0.003
2833 Dihydrofolate reductase Not Available 0.003
2931 Dihydrofolate reductase folA 0.003
3544 Dihydrofolate reductase folA 0.003
3682 Dihydrofolate reductase folA 0.003
6642 Dihydrofolate reductase folA 0.003
6756 Dihydrofolate reductase dfrA 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
319 Opioid receptor, sigma 1 OPRS1 0.0028
489 Monocarboxylate transporter 2 SLC16A7 0.0028
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
88 Retinoic acid receptor RXR-beta RXRB 0.0028
172 Potassium channel subfamily K member 1 KCNK1 0.0028
976 Platelet glycoprotein IX GP9 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1374 Natriuretic peptides B NPPB 0.0027
1827 Gap junction alpha-1 protein GJA1 0.0027
1908 Vascular cell adhesion protein 1 VCAM1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
569 Retinal dehydrogenase 2 ALDH1A2 0.0027
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0027
183 Vascular endothelial growth factor A VEGFA 0.0027
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0027
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0026
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0026
3587 Gastrotropin FABP6 0.0026
291 Nitric-oxide synthase, endothelial NOS3 0.0026
6824 Tyrosine-protein kinase Lyn LYN 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0026
6837 Serine/threonine-protein kinase 17B STK17B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
49 Endothelin B receptor EDNRB 0.0026
427 Substance-P receptor TACR1 0.0026
54 Prothrombin F2 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
611 Retinal dehydrogenase 1 ALDH1A1 0.0025
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0025
6044 Serum paraoxonase/lactonase 3 PON3 0.0025
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0024
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0024
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0024
705 Glutamate receptor 1 GRIA1 0.0024
342 P protein [Includes: DNA-directed DNA polymerase P 0.0024
612 P protein [Includes: DNA-directed DNA polymerase P 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
482 Glycine receptor subunit alpha-1 GLRA1 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0023
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0023
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0023
572 Integrin alpha-L ITGAL 0.0023
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0023
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0023
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0023
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0023
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
6126 Carbonic anhydrase 7 CA7 0.0023
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0022
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0022
1992 Vitamin D-binding protein GC 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0022
517 Alcohol dehydrogenase 1C ADH1C 0.0022
2981 Phospholipase A2, membrane associated PLA2G2A 0.0022
6131 Carbonic anhydrase 14 CA14 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
3810 Catechol O-methyltransferase COMT 0.0021
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
6432 Transporter snf 0.002
6122 Carbonic anhydrase 3 CA3 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.002
444 Alcohol dehydrogenase 1B ADH1B 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
6218 Pannexin-1 PANX1 0.002
5787 Angiopoietin-1 receptor TEK 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0019
1275 Estrogen sulfotransferase SULT1E1 0.0019
511 5-hydroxytryptamine 1F receptor HTR1F 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0019
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0019
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0019
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0019
251 Alcohol dehydrogenase 1A ADH1A 0.0019
162 Retinoic acid receptor gamma-1 RARG 0.0019
5998 Toll-like receptor 8 TLR8 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
770 Retinoic acid-induced protein 3 GPRC5A 0.0018
719 Retinoic acid receptor responder protein 1 RARRES1 0.0018
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0018
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
1618 High affinity nerve growth factor receptor NTRK1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
634 Squalene monooxygenase SQLE 0.0017
7196 Squalene monooxygenase ERG1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
1313 Lactoylglutathione lyase GLO1 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
6174 50S ribosomal protein L32 rpmF 0.0016
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0016
4041 Microsomal glutathione S-transferase 2 MGST2 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0016
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0016
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0016
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
6755 Poliovirus receptor PVR 0.0015
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0015
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0015
5818 Folate receptor alpha FOLR1 0.0015
6042 Prostaglandin reductase 2 PTGR2 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0015
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1541 Metalloproteinase mmp20 0.0014
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0014
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0014
422 Vitamin K-dependent protein C PROC 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
293 Gamma-glutamyl hydrolase GGH 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
4031 Glutathione S-transferase A1 GSTA1 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
3007 Carbonic anhydrase 12 CA12 0.0013
4205 Carbonic anhydrase 9 CA9 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
6859 Protein S100-A4 S100A4 0.0012
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0012
2540 Choloylglycine hydrolase cbh 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
798 Osteocalcin BGLAP 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
6501 Fatty acid-binding protein, liver FABP1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
4217 Telomerase reverse transcriptase TERT 0.001
369 Coagulation factor VII F7 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
345 Plasma retinol-binding protein RBP4 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
6500 Phospholipase A2 PLA2G1B 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
1864 RET proto-oncogene RET 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0008
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0008
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
760 Fibroblast growth factor 1 FGF1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
125 DNA polymerase beta POLB 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
563 Thyroid peroxidase TPO 0.0006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2021 Thrombomodulin THBD 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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