DT-Web

DB01138 - Sulfinpyrazone


Identification
Name Sulfinpyrazone
Accession Number DB01138 (APRD00620)
Type small molecule
Description A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 404.482
Groups approved
Monoisotopic Weight 404.119463206
Pharmacology
Indication For the treatment of gout and gouty arthritis.
Mechanism of action Sulfinpyrazone is an oral uricosuric agent (pyrazolone derivative) used to treat chronic or intermittent gouty arthritis. Sulfinpyrazone competitively inhibits the reabsorption of uric acid at the proximal convoluted tubule, thereby facilitating urinary excretion of uric acid and decreasing plasma urate concentrations. This is likely done through inhibition of the urate anion transporter (hURAT1) as well as the human organic anion transporter 4 (hOAT4). Sulfinpyrazone is not intended for the treatment of acute attacks because it lacks therapeutically useful analgesic and anti-inflammatory effects. Sulfinpyrazone and its sulfide metabolite possess COX inhibitory effects. Sulfinpyrazone has also been shown to be a UDP-glucuronsyltransferase inhibitor and a very potent CYP2C9 inhibitor. Sulfinpyrazone is also known to be a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor as well as an inhibitor of several multridrug resistance proteins (MRPs).
Absorption Not Available
Protein binding 98-99%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Symptoms of overdose include nausea, vomiting, diarrhea, epigastric pain, ataxia, labored respiration, convulsions, coma. Possible symptoms, seen after overdosage with other pyrazolone derivatives: anemia, jaundice, and ulceration.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Cyclosporine Sulfinpyrazone decreases the effect of cyclosporine
Tolbutamide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Sulfinpyrazone. Consider alternate therapy or monitor for changes in Sulfinpyrazone therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Warfarin Sulfinpyrazone may increase the anticoagulant effect of warfarin by decreasing its metabolism and protein binding.
Food Interactions Not Available

Targets


Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Pharmacological action yes
Actions inhibitor
References
  • Bakos E, Evers R, Sinko E, Varadi A, Borst P, Sarkadi B: Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. - Pubmed
  • Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. - Pubmed
  • Morrow CS, Smitherman PK, Townsend AJ: Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells. Mol Carcinog. 2000 Nov;29(3):170-8. - Pubmed
  • Ito K, Oleschuk CJ, Westlake C, Vasa MZ, Deeley RG, Cole SP: Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. J Biol Chem. 2001 Oct 12;276(41):38108-14. Epub 2001 Aug 10. - Pubmed
  • Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ: Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 2002;64(3):126-34. - Pubmed
  • Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A: Human renal organic anion transporter 4 operates as an asymmetric urate transporter. J Am Soc Nephrol. 2007 Feb;18(2):430-9. Epub 2007 Jan 17. - Pubmed
DTHybrid score 0.3658
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Pharmacological action yes
Actions inhibitor
References
  • Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. - Pubmed
  • Morrow CS, Smitherman PK, Diah SK, Schneider E, Townsend AJ: Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells. J Biol Chem. 1998 Aug 7;273(32):20114-20. - Pubmed
  • Bakos E, Evers R, Sinko E, Varadi A, Borst P, Sarkadi B: Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8. - Pubmed
  • Depeille P, Cuq P, Mary S, Passagne I, Evrard A, Cupissol D, Vian L: Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects. Mol Pharmacol. 2004 Apr;65(4):897-905. - Pubmed
  • Raggers RJ, van Helvoort A, Evers R, van Meer G: The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane. J Cell Sci. 1999 Feb;112 ( Pt 3):415-22. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3296

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5282
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6546
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3415
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4136

Transporters


Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions inhibitor
References
  • Zelcer N, Saeki T, Reid G, Beijnen JH, Borst P: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7. - Pubmed
DTHybrid score 0.2398
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions inhibitor
References
  • Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H, Kruh GD: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. - Pubmed
DTHybrid score 0.3157
Multidrug resistance-associated protein 5
Name Multidrug resistance-associated protein 5
Gene Name ABCC5
Actions inhibitor
References
  • Wijnholds J, Mol CA, van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J, Borst P: Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7476-81. - Pubmed
DTHybrid score 0.2028
Multidrug resistance-associated protein 6
Name Multidrug resistance-associated protein 6
Gene Name ABCC6
Actions inhibitor
References
  • Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed
DTHybrid score 0.1943
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Honda Y, Ushigome F, Koyabu N, Morimoto S, Shoyama Y, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. Br J Pharmacol. 2004 Dec;143(7):856-64. Epub 2004 Oct 25. - Pubmed
DTHybrid score 0.5438
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor
References
  • Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. - Pubmed
DTHybrid score 0.3296
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate,inhibitor
References
  • Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ: Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 2002;64(3):126-34. - Pubmed
  • Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. - Pubmed
DTHybrid score 0.3658

Carriers


Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions
References Not Available
DTHybrid score 0.2398
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions
References Not Available
DTHybrid score 0.3157
Multidrug resistance-associated protein 5
Name Multidrug resistance-associated protein 5
Gene Name ABCC5
Actions
References Not Available
DTHybrid score 0.2028
Multidrug resistance-associated protein 6
Name Multidrug resistance-associated protein 6
Gene Name ABCC6
Actions
References Not Available
DTHybrid score 0.1943
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.5438
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions
References Not Available
DTHybrid score 0.3296
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions
References Not Available
DTHybrid score 0.3658

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.3096
4119 Cytochrome P450 2D6 CYP2D6 0.2822
4118 Cytochrome P450 3A5 CYP3A5 0.2513
4200 Cytochrome P450 1A2 CYP1A2 0.247
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.2303
6107 Cytochrome P450 3A7 CYP3A7 0.1763
587 Serum albumin ALB 0.1712
6013 Cytochrome P450 2E1 CYP2E1 0.1574
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1383
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1364
20 Prostaglandin G/H synthase 1 PTGS1 0.1293
1729 Solute carrier family 22 member 6 SLC22A6 0.1287
6142 Solute carrier family 22 member 8 SLC22A8 0.1167
5718 Cytochrome P450 2A6 CYP2A6 0.1124
776 Bile salt export pump ABCB11 0.1092
6024 Cytochrome P450 1A1 CYP1A1 0.1084
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.096
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0923
290 Prostaglandin G/H synthase 2 PTGS2 0.0866
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0858
6143 Solute carrier family 22 member 7 SLC22A7 0.0853
6148 Multidrug resistance-associated protein 7 ABCC10 0.0842
6144 Solute carrier family 22 member 2 SLC22A2 0.0837
817 DNA topoisomerase 2-alpha TOP2A 0.079
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0778
1024 Solute carrier family 22 member 11 SLC22A11 0.0698
6145 Solute carrier family 22 member 1 SLC22A1 0.0667
118 Organic cation/carnitine transporter 2 SLC22A5 0.0663
1898 Cytochrome P450 1B1 CYP1B1 0.066
6106 Cytochrome P450 2C18 CYP2C18 0.0634
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0627
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0622
6141 Sodium/bile acid cotransporter SLC10A1 0.0605
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0564
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0544
136 Estrogen receptor ESR1 0.0541
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0523
6147 Solute carrier family 22 member 3 SLC22A3 0.0504
2183 Fatty acid-binding protein, adipocyte FABP4 0.0493
3811 Cytochrome P450 19A1 CYP19A1 0.0492
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0482
492 Histamine H1 receptor HRH1 0.0453
731 HIV-1 protease HIV-1 protease 0.0441
24 Thymidylate synthase TMP1 0.0438
359 Thymidylate synthase TYMS 0.0438
2626 Thymidylate synthase thyA 0.0438
2729 Thymidylate synthase thyA 0.0438
5352 Thymidylate synthase THYA 0.0438
2853 14 kDa fatty acid-binding protein Not Available 0.0424
3947 Xanthine dehydrogenase/oxidase XDH 0.0422
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0418
824 Sodium-dependent serotonin transporter SLC6A4 0.0416
468 Cytochrome P450 4A11 CYP4A11 0.0404
5626 Nucleoside diphosphate kinase B NME2 0.037
908 Glutathione S-transferase theta-1 GSTT1 0.0358
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0353
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0352
871 Glucocorticoid receptor NR3C1 0.035
220 Sodium channel protein type 5 subunit alpha SCN5A 0.035
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0349
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0347
4604 Liver carboxylesterase 1 CES1 0.0344
161 Tubulin beta chain TUBB 0.0337
312 Tubulin beta chain TUB2 0.0337
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0334
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0334
738 Monocarboxylate transporter 1 SLC16A1 0.0332
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.033
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0328
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0326
4120 NADPH--cytochrome P450 reductase POR 0.0315
70 Type-1 angiotensin II receptor AGTR1 0.0312
556 Alpha-1A adrenergic receptor ADRA1A 0.0297
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0296
904 Glutathione S-transferase P GSTP1 0.0296
5294 Nucleoside diphosphate kinase A NME1 0.0295
502 5-hydroxytryptamine 2A receptor HTR2A 0.0293
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0291
3923 Cholinesterase BCHE 0.0287
831 D(2) dopamine receptor DRD2 0.0278
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0271
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0266
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0264
6149 Solute carrier family 22 member 10 SLC22A10 0.0258
4192 DNA topoisomerase 2-beta TOP2B 0.0256
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0255
465 Calmodulin CALM1 0.0254
260 Cytochrome P450 51 ERG11 0.0253
761 Cytochrome P450 51 ERG11 0.0253
3163 Cytochrome P450 51 cyp51 0.0253
847 Mu-type opioid receptor OPRM1 0.0253
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0253
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0249
614 Progesterone receptor PGR 0.0243
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0243
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0241
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0241
3616 Fatty acid-binding protein, epidermal FABP5 0.0239
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0239
5433 UPF0230 protein TM_1468 TM_1468 0.0239
5431 Lipid binding protein Not Available 0.0239
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0236
3917 Methylenetetrahydrofolate reductase MTHFR 0.0235
6020 Aldehyde oxidase AOX1 0.0232
342 P protein [Includes: DNA-directed DNA polymerase P 0.023
612 P protein [Includes: DNA-directed DNA polymerase P 0.023
122 P2Y purinoceptor 12 P2RY12 0.0229
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0229
833 Organic cation/carnitine transporter 1 SLC22A4 0.0228
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0226
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0225
477 DNA topoisomerase 4 subunit A parC 0.0225
886 DNA topoisomerase 4 subunit A parC 0.0225
6226 DNA topoisomerase 4 subunit A parC 0.0225
467 Delta-type opioid receptor OPRD1 0.0224
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0224
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0223
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0221
404 DNA gyrase subunit A gyrA 0.0221
6224 DNA gyrase subunit A gyrA 0.0221
6031 Cytochrome P450 3A43 CYP3A43 0.0221
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0218
273 Apoptosis regulator Bcl-2 BCL2 0.0217
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0217
869 Estrogen receptor beta ESR2 0.0216
1629 Transcription factor AP-1 JUN 0.0216
696 Kappa-type opioid receptor OPRK1 0.0212
29 Tubulin beta-1 chain TUBB1 0.0211
6218 Pannexin-1 PANX1 0.0211
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.021
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.021
504 Mast/stem cell growth factor receptor KIT 0.0206
318 Alpha-2A adrenergic receptor ADRA2A 0.0206
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0205
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0205
6167 Organic solute transporter subunit beta OSTB 0.0202
6166 Organic solute transporter subunit alpha OSTA 0.0202
896 Glutathione S-transferase Mu 1 GSTM1 0.0202
952 Dipeptidyl peptidase 4 DPP4 0.0201
713 Sodium-dependent dopamine transporter SLC6A3 0.0199
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0197
6146 High affinity copper uptake protein 1 SLC31A1 0.0196
6210 Tubulin delta chain TUBD1 0.0196
6212 Tubulin gamma-1 chain TUBG1 0.0196
6211 Tubulin epsilon chain TUBE1 0.0196
6459 Glycodelin PAEP 0.0196
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0195
1757 Myeloperoxidase MPO 0.0195
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0192
2211 Fatty acid-binding protein, heart FABP3 0.0192
3685 Catabolite gene activator crp 0.0191
4655 Adenylate cyclase cyaC 0.0191
4759 Adenylate cyclase cyaB2 0.0191
450 Muscarinic acetylcholine receptor M4 CHRM4 0.019
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0186
2021 Thrombomodulin THBD 0.0186
6163 Copper-transporting ATPase 2 ATP7B 0.0186
6165 Copper-transporting ATPase 1 ATP7A 0.0186
283 SEC14-like protein 2 SEC14L2 0.0185
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0184
146 Androgen receptor AR 0.0182
2449 Tubulin alpha-3 chain TUBA1A 0.0182
6677 Myelin P2 protein PMP2 0.0181
632 Alpha-1B adrenergic receptor ADRA1B 0.0177
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0176
590 5-hydroxytryptamine 2C receptor HTR2C 0.0176
1405 Thiopurine S-methyltransferase TPMT 0.0172
891 Dihydropteroate synthase folP 0.0171
5359 Dihydropteroate synthase folP 0.0171
7175 Dihydropteroate synthase sulI 0.0171
6182 Cytochrome P450 2J2 CYP2J2 0.0171
1650 Heme carrier protein 1 SLC46A1 0.0171
26 Vascular endothelial growth factor receptor 3 FLT4 0.0171
6220 Aryl hydrocarbon receptor AHR 0.017
4152 Superoxide dismutase [Cu-Zn] SOD1 0.017
756 Sex hormone-binding globulin SHBG 0.017
766 Beta-2 adrenergic receptor ADRB2 0.017
293 Gamma-glutamyl hydrolase GGH 0.0168
489 Monocarboxylate transporter 2 SLC16A7 0.0167
3957 Adenosine deaminase ADA 0.0166
407 Vascular endothelial growth factor receptor 2 KDR 0.0166
32 Vascular endothelial growth factor receptor 1 FLT1 0.0163
4760 Mll3241 protein mll3241 0.0163
4226 Uridine phosphorylase 2 UPP2 0.0162
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0161
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0161
844 Epidermal growth factor receptor EGFR 0.016
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.016
380 Cytochrome P450 17A1 CYP17A1 0.016
341 5-hydroxytryptamine 3 receptor HTR3A 0.0158
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0158
228 Beta platelet-derived growth factor receptor PDGFRB 0.0157
23 D(1A) dopamine receptor DRD1 0.0157
320 5-hydroxytryptamine 1A receptor HTR1A 0.0156
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0155
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0155
3941 Amine oxidase [flavin-containing] A MAOA 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0154
6043 Putative G-protein coupled receptor 44 GPR44 0.0154
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0153
2207 Rhodopsin RHO 0.0152
1313 Lactoylglutathione lyase GLO1 0.0152
275 Arachidonate 5-lipoxygenase ALOX5 0.015
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.015
6599 HTH-type transcriptional regulator ttgR ttgR 0.015
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0149
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0149
6171 Solute carrier family 28 member 3 SLC28A3 0.0149
193 Beta-1 adrenergic receptor ADRB1 0.0149
2981 Phospholipase A2, membrane associated PLA2G2A 0.0146
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0146
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0145
4225 Uridine phosphorylase 1 UPP1 0.0145
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0142
2539 Tubulin alpha-1 chain TUBA4A 0.0141
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.014
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.014
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0139
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0139
413 Amidophosphoribosyltransferase PPAT 0.0138
2515 Amidophosphoribosyltransferase purF 0.0138
3714 Amidophosphoribosyltransferase purF 0.0138
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0137
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0137
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0136
789 Alpha-1D adrenergic receptor ADRA1D 0.0135
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0135
33 Cystine/glutamate transporter SLC7A11 0.0135
6042 Prostaglandin reductase 2 PTGR2 0.0134
1792 Tissue-type plasminogen activator PLAT 0.0133
185 Vasopressin V1a receptor AVPR1A 0.0131
4217 Telomerase reverse transcriptase TERT 0.013
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.013
3307 Acriflavine resistance protein B acrB 0.013
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.013
3587 Gastrotropin FABP6 0.0129
284 DNA-directed RNA polymerase beta chain rpoB 0.0129
5773 DNA-directed RNA polymerase beta chain rpoB 0.0129
811 Translocator protein TSPO 0.0129
3939 Amine oxidase [flavin-containing] B MAOB 0.0128
365 Dihydrofolate reductase DHFR 0.0128
2381 Dihydrofolate reductase DFR1 0.0128
2833 Dihydrofolate reductase Not Available 0.0128
2931 Dihydrofolate reductase folA 0.0128
3544 Dihydrofolate reductase folA 0.0128
3682 Dihydrofolate reductase folA 0.0128
6642 Dihydrofolate reductase folA 0.0128
6756 Dihydrofolate reductase dfrA 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
165 FL cytokine receptor FLT3 0.0127
3639 Thymidine phosphorylase deoA 0.0127
3936 Thymidine phosphorylase TYMP 0.0127
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0126
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0125
737 Mineralocorticoid receptor NR3C2 0.0124
1852 Microtubule-associated protein 2 MAP2 0.0124
6138 Multidrug resistance protein 3 ABCB4 0.0123
950 Alpha platelet-derived growth factor receptor PDGFRA 0.012
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.012
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.012
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0119
6168 Solute carrier family 22 member 16 SLC22A16 0.0119
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0119
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0118
1648 Elastin ELN 0.0118
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
818 50S ribosomal protein L10 rplJ 0.0117
3810 Catechol O-methyltransferase COMT 0.0117
299 Folate receptor beta FOLR2 0.0117
718 Folate receptor gamma FOLR3 0.0117
804 Mitochondrial folate transporter/carrier SLC25A32 0.0116
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0116
702 UMP-CMP kinase CMPK1 0.0115
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0115
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0113
4773 Deoxycytidine kinase DCK 0.0112
373 Transthyretin TTR 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0112
777 Tumor necrosis factor TNF 0.0111
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0111
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0111
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.011
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.011
890 Niemann-Pick C1-like protein 1 NPC1L1 0.011
3932 Glutathione S-transferase A2 GSTA2 0.011
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0109
2443 Azurin azu 0.0108
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0107
5923 Microtubule-associated protein tau MAPT 0.0107
5924 Microtubule-associated protein 4 MAP4 0.0107
638 D(3) dopamine receptor DRD3 0.0106
1353 DNA topoisomerase 1 TOP1 0.0106
3552 DNA topoisomerase 1 topA 0.0106
885 5-hydroxytryptamine 1B receptor HTR1B 0.0105
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0104
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0104
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0104
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0104
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0103
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0103
7 Nitric oxide synthase, inducible NOS2 0.0103
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0102
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0101
2616 Ganglioside GM2 activator GM2A 0.01
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.01
461 Glycine receptor subunit alpha-3 GLRA3 0.01
1192 Sulfotransferase 1A1 SULT1A1 0.01
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0098
2320 Thymidine kinase, cytosolic TK1 0.0098
725 5-hydroxytryptamine 1D receptor HTR1D 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
1760 Aminopeptidase N ANPEP 0.0097
6843 Aminopeptidase N pepN 0.0097
723 Cytosolic phospholipase A2 PLA2G4A 0.0097
4237 50S ribosomal protein L22 rplV 0.0097
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0095
117 Sterol O-acyltransferase 1 SOAT1 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0095
174 Sigma 1-type opioid receptor SIGMAR1 0.0094
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0094
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0094
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0094
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0094
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0093
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0093
124 Histamine H2 receptor HRH2 0.0093
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
3809 Estrogen-related receptor gamma ESRRG 0.0092
436 5-hydroxytryptamine 2B receptor HTR2B 0.0092
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.0091
629 Alpha-2B adrenergic receptor ADRA2B 0.009
1656 CYP2B protein CYP2B 0.009
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.009
1050 Bile salt sulfotransferase SULT2A1 0.009
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0089
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0088
6102 Arylamine N-acetyltransferase 2 NAT2 0.0088
427 Substance-P receptor TACR1 0.0088
2808 Chloramphenicol acetyltransferase 3 cat3 0.0088
921 Glutamate receptor 2 GRIA2 0.0088
482 Glycine receptor subunit alpha-1 GLRA1 0.0087
1010 Cytochrome P450 51A1 CYP51A1 0.0087
4238 50S ribosomal protein L4 rplD 0.0085
5578 50S ribosomal protein L4 rplD 0.0085
6173 50S ribosomal protein L4 rplD 0.0085
6219 50S ribosomal protein L4 rplD 0.0085
474 Acetylcholinesterase ACHE 0.0084
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0082
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0082
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0081
850 Vasopressin V1b receptor AVPR1B 0.0081
768 FK506-binding protein 1A FKBP1A 0.0081
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0081
4210 Toll-like receptor 4 TLR4 0.008
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
5787 Angiopoietin-1 receptor TEK 0.008
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.008
291 Nitric-oxide synthase, endothelial NOS3 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
76 Nitric-oxide synthase, brain NOS1 0.0078
2298 Cytochrome P450-cam camC 0.0077
6755 Poliovirus receptor PVR 0.0077
295 Carbonic anhydrase 1 CA1 0.0077
716 5-hydroxytryptamine 7 receptor HTR7 0.0077
5818 Folate receptor alpha FOLR1 0.0076
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0075
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0075
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0074
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0074
1541 Metalloproteinase mmp20 0.0074
6033 High affinity interleukin-8 receptor A CXCR1 0.0074
4034 Glutaredoxin-1 GLRX 0.0074
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0074
1928 Leukotriene C4 synthase LTC4S 0.0074
4037 Hypothetical protein GPX1 0.0074
4297 Hypothetical protein SP_1951 0.0074
4521 Hypothetical protein BC_2969 0.0074
4540 Hypothetical protein TM_1070 0.0074
4555 Hypothetical protein MT1739 0.0074
4569 Hypothetical protein mshD 0.0074
4578 Hypothetical protein PA3270 0.0074
4747 Hypothetical protein PA3967 0.0074
5177 Hypothetical protein TM_0096 0.0074
5194 Hypothetical protein PA1204 0.0074
5240 Hypothetical protein Rv2991 0.0074
5370 Hypothetical protein TM_1158 0.0074
5710 Hypothetical protein Tb927.5.1360 0.0074
4029 Microsomal glutathione S-transferase 3 MGST3 0.0074
4032 Microsomal glutathione S-transferase 1 MGST1 0.0074
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0074
910 Epididymal secretory glutathione peroxidase GPX5 0.0074
4035 Glutathione S-transferase Mu 5 GSTM5 0.0074
4040 Glutathione peroxidase 7 GPX7 0.0074
4036 Glutathione peroxidase 6 GPX6 0.0074
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0074
903 Glutathione S-transferase A5 GSTA5 0.0074
911 Glutathione peroxidase 3 GPX3 0.0074
906 Glutathione peroxidase 1 GPX1 0.0074
907 Glutathione peroxidase 2 GPX2 0.0074
900 Glutathione S-transferase A4 GSTA4 0.0074
4038 Glutathione peroxidase 4 GPX4 0.0074
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0074
4042 Glutathione transferase omega-2 GSTO2 0.0074
4033 S-formylglutathione hydrolase ESD 0.0074
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0074
183 Vascular endothelial growth factor A VEGFA 0.0073
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0073
4041 Microsomal glutathione S-transferase 2 MGST2 0.0073
88 Retinoic acid receptor RXR-beta RXRB 0.0072
394 Calcineurin subunit B isoform 1 PPP3R1 0.0071
6753 Apolipoprotein M APOM 0.0071
6742 Recoverin RCVRN 0.0071
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0071
6743 Non-fluorescent flavoprotein luxF 0.0071
2528 Fatty acid metabolism regulator protein fadR 0.0071
6740 Fatty acid metabolism regulator protein fadR 0.0071
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0071
6751 Gag polyprotein gag 0.0071
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0071
6747 Chalcone/stilbene synthase family protein MT1417 0.0071
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0071
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0071
6749 Polyprotein Not Available 0.0071
378 Alpha-2C adrenergic receptor ADRA2C 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
705 Glutamate receptor 1 GRIA1 0.007
2391 Ferrochelatase hemH 0.007
6502 Ferrochelatase DKFZp686P18130 0.007
1591 Ferrochelatase, mitochondrial FECH 0.007
131 Synaptic vesicular amine transporter SLC18A2 0.0069
6228 Nuclear receptor coactivator 1 NCOA1 0.0069
49 Endothelin B receptor EDNRB 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0068
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0068
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0068
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0068
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0068
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0067
592 Carbonic anhydrase 4 CA4 0.0067
3319 Hydroxyacylglutathione hydrolase HAGH 0.0066
897 Glutathione S-transferase kappa 1 GSTK1 0.0066
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0066
898 Glutathione S-transferase A3 GSTA3 0.0066
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0066
94 5-hydroxytryptamine 4 receptor HTR4 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0065
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0065
909 Maleylacetoacetate isomerase GSTZ1 0.0065
357 Carbonic anhydrase 2 CA2 0.0064
5961 Insulin INS 0.0064
2599 Tyrosine-protein kinase HCK HCK 0.0064
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0064
905 Glutathione transferase omega-1 GSTO1 0.0064
899 Glutathione S-transferase Mu 3 GSTM3 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
6014 Cytochrome P450 2A13 CYP2A13 0.0063
5482 Sialidase-2 NEU2 0.0062
3270 Elongation factor G fusA 0.0062
6527 Lymphocyte antigen 96 LY96 0.0062
537 ATP synthase delta chain, mitochondrial ATP5D 0.0062
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0062
6837 Serine/threonine-protein kinase 17B STK17B 0.0062
4203 Histamine N-methyltransferase HNMT 0.0061
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0061
2297 Genome polyprotein Not Available 0.0061
2322 Genome polyprotein Not Available 0.0061
2694 Genome polyprotein Not Available 0.0061
2719 Genome polyprotein Not Available 0.0061
2860 Genome polyprotein Not Available 0.0061
2928 Genome polyprotein Not Available 0.0061
3160 Genome polyprotein Not Available 0.0061
3260 Genome polyprotein Not Available 0.0061
4783 Genome polyprotein Not Available 0.0061
5726 Genome polyprotein Not Available 0.0061
5779 Genome polyprotein Not Available 0.0061
5867 Genome polyprotein Not Available 0.0061
6253 Genome polyprotein Not Available 0.0061
6301 Genome polyprotein Not Available 0.0061
6380 Genome polyprotein Not Available 0.0061
6381 Genome polyprotein Not Available 0.0061
6437 Genome polyprotein Not Available 0.0061
6520 Genome polyprotein Not Available 0.0061
6521 Genome polyprotein Not Available 0.0061
6652 Genome polyprotein Not Available 0.0061
6734 Genome polyprotein Not Available 0.0061
6735 Genome polyprotein Not Available 0.0061
6736 Genome polyprotein Not Available 0.0061
6737 Genome polyprotein Not Available 0.0061
6738 Genome polyprotein Not Available 0.0061
6739 Genome polyprotein Not Available 0.0061
6744 Genome polyprotein Not Available 0.0061
6748 Genome polyprotein Not Available 0.0061
6894 Genome polyprotein Not Available 0.0061
6898 Genome polyprotein Not Available 0.0061
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0061
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0061
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0061
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0061
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.006
6493 Cytochrome c oxidase subunit 6C COX6C 0.006
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.006
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.006
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.006
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.006
6559 Cytochrome c oxidase subunit 2 ctaC 0.006
6669 Cytochrome c oxidase subunit 2 ctaC 0.006
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.006
371 Cytochrome c oxidase subunit 1 MT-CO1 0.006
6558 Cytochrome c oxidase subunit 1 ctaD 0.006
1630 Integrin beta-2 ITGB2 0.006
319 Opioid receptor, sigma 1 OPRS1 0.006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0059
856 Vitamin D3 receptor VDR 0.0059
992 Protein tyrosine kinase 2 beta PTK2B 0.0059
2232 Interleukin-5 IL5 0.0059
84 Nuclear receptor 0B1 NR0B1 0.0059
1593 Mucin-2 MUC2 0.0059
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0059
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0058
2165 Glutathione S-transferase Mu 2 GSTM2 0.0058
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0058
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0058
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0058
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0057
207 Glutathione synthetase GSS 0.0057
5269 Glutathione synthetase gshB 0.0057
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0057
6750 ADP-ribosylation factor 6 ARF6 0.0057
6524 Protein tonB tonB 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
4031 Glutathione S-transferase A1 GSTA1 0.0057
558 Solute carrier family 12 member 1 SLC12A1 0.0056
432 D(4) dopamine receptor DRD4 0.0056
68 Cannabinoid receptor 1 CNR1 0.0055
517 Alcohol dehydrogenase 1C ADH1C 0.0055
2540 Choloylglycine hydrolase cbh 0.0055
780 Retinoic acid receptor RXR-gamma RXRG 0.0055
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0055
469 Annexin A1 ANXA1 0.0055
4122 Histone deacetylase 2 HDAC2 0.0055
814 Ryanodine receptor 1 RYR1 0.0055
901 Glutathione S-transferase Mu 4 GSTM4 0.0054
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0054
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0053
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0053
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0052
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0052
6501 Fatty acid-binding protein, liver FABP1 0.0052
1618 High affinity nerve growth factor receptor NTRK1 0.0052
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0052
6316 ADP-ribosylation factor 1 ARF1 0.0052
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0052
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0051
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.005
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.005
5300 Antigen peptide transporter 1 TAP1 0.005
1275 Estrogen sulfotransferase SULT1E1 0.005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0049
1178 Adenosine A2a receptor ADORA2A 0.0049
1123 Eosinophil cationic protein RNASE3 0.0049
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0049
581 Cytochrome P450 2R1 CYP2R1 0.0048
714 Glutathione reductase, mitochondrial GSR 0.0047
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0047
1198 Serum paraoxonase/arylesterase 1 PON1 0.0047
162 Retinoic acid receptor gamma-1 RARG 0.0047
6223 Penicillin-binding protein 1C pbpC 0.0047
683 Potassium transporter GK0582 0.0047
864 Gag-Pol polyprotein gag-pol 0.0046
2237 Gag-Pol polyprotein gag-pol 0.0046
2326 Gag-Pol polyprotein gag-pol 0.0046
2451 Gag-Pol polyprotein gag-pol 0.0046
2901 Gag-Pol polyprotein gag-pol 0.0046
3165 Gag-Pol polyprotein gag-pol 0.0046
3722 Gag-Pol polyprotein gag-pol 0.0046
6306 Gag-Pol polyprotein gag-pol 0.0046
6624 Gag-Pol polyprotein gag-pol 0.0046
823 Fibroblast growth factor receptor 2 FGFR2 0.0045
54 Prothrombin F2 0.0045
239 Coagulation factor X F10 0.0045
527 Prostacyclin receptor PTGIR 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
4103 Proteasome subunit beta type 2 PSMB2 0.0044
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0044
4102 Proteasome subunit beta type 5 PSMB5 0.0044
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0044
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0044
4101 Proteasome subunit beta type 1 PSMB1 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6500 Phospholipase A2 PLA2G1B 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0042
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0042
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0042
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0042
6174 50S ribosomal protein L32 rpmF 0.0042
1569 G1/S-specific cyclin-D1 CCND1 0.0041
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0041
16 Adenosine A1 receptor ADORA1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
2427 Ferrichrome-iron receptor fhuA 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
751 Potassium channel subfamily K member 6 KCNK6 0.0039
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0038
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0038
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0038
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
6044 Serum paraoxonase/lactonase 3 PON3 0.0038
528 5-hydroxytryptamine 1E receptor HTR1E 0.0038
3856 Fibroblast growth factor receptor 3 FGFR3 0.0038
6126 Carbonic anhydrase 7 CA7 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0037
518 Peroxidase/catalase T katG 0.0037
1992 Vitamin D-binding protein GC 0.0036
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0036
572 Integrin alpha-L ITGAL 0.0036
172 Potassium channel subfamily K member 1 KCNK1 0.0035
2112 Toll-like receptor 9 TLR9 0.0035
563 Thyroid peroxidase TPO 0.0035
939 50S ribosomal protein L3 rplC 0.0035
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0035
645 Penicillin-binding protein 1A mrcA 0.0035
5805 Penicillin-binding protein 1A ponA 0.0035
6185 Penicillin-binding protein 1A mrcA 0.0035
6799 Penicillin-binding protein 1A pbpA 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0034
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0034
1714 Mitogen-activated protein kinase 3 MAPK3 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
163 D(1B) dopamine receptor DRD5 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0033
6824 Tyrosine-protein kinase Lyn LYN 0.0033
5880 Thrombopoietin receptor MPL 0.0033
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0033
6432 Transporter snf 0.0033
936 Ephrin type-A receptor 2 EPHA2 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0031
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0031
1256 5-hydroxytryptamine 6 receptor HTR6 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
5798 Mitogen-activated protein kinase 11 MAPK11 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
115 Penicillin-binding protein 2 mrdA 0.003
6069 Penicillin-binding protein 2 mrdA 0.003
6118 Penicillin-binding protein 2 penA 0.003
6187 Penicillin-binding protein 2 pbpA 0.003
6686 Penicillin-binding protein 2 pbp2 0.003
6939 Penicillin-binding protein 2 mrdA 0.003
7163 Penicillin-binding protein 2 pbpA 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6241 Nuclear receptor coactivator 2 NCOA2 0.003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
719 Retinoic acid receptor responder protein 1 RARRES1 0.0028
770 Retinoic acid-induced protein 3 GPRC5A 0.0028
605 Fumarate reductase flavoprotein subunit frdA 0.0028
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0028
3673 Fumarate reductase flavoprotein subunit fccA 0.0028
4912 Fumarate reductase flavoprotein subunit ifcA 0.0028
6549 Fumarate reductase flavoprotein subunit frdA 0.0028
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
634 Squalene monooxygenase SQLE 0.0028
7196 Squalene monooxygenase ERG1 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0028
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0028
1 Peptidoglycan synthetase ftsI ftsI 0.0028
4155 Peptidoglycan synthetase ftsI ftsI 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
976 Platelet glycoprotein IX GP9 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0027
4311 tRNA TRDMT1 0.0026
4325 tRNA trmD 0.0026
4328 tRNA trmD 0.0026
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0026
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
511 5-hydroxytryptamine 1F receptor HTR1F 0.0026
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0026
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
569 Retinal dehydrogenase 2 ALDH1A2 0.0025
267 Plasminogen activator inhibitor 1 SERPINE1 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
3808 Dihydropteroate synthase 2 folP2 0.0025
3601 Dihydropteroate synthase 1 folP1 0.0025
3807 Dihydropteroate synthase 1 folP1 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0025
3937 Fatty-acid amide hydrolase FAAH 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
164 Histamine H4 receptor HRH4 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
444 Alcohol dehydrogenase 1B ADH1B 0.0023
6221 Steroid hormone receptor ERR1 ESRRA 0.0023
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0023
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0023
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0022
1039 Histone deacetylase 9 HDAC9 0.0022
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0022
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
251 Alcohol dehydrogenase 1A ADH1A 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0021
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0021
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0021
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0021
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0021
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0021
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0021
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
820 Glycine receptor subunit alpha-2 GLRA2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0019
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0019
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
5998 Toll-like receptor 8 TLR8 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
268 Adenosine A2b receptor ADORA2B 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0017
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0017
1268 Neuropeptide S receptor NPSR1 0.0017
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0017
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0017
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
1360 Sphingomyelin phosphodiesterase SMPD1 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1341 Histamine H3 receptor HRH3 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
3221 Cytochrome c4 cc4 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
1864 RET proto-oncogene RET 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
292 Activin receptor type-1 ACVR1 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
6151 Monocarboxylate transporter 10 SLC16A10 0.0012
6859 Protein S100-A4 S100A4 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
4920 Peroxidase/catalase katG 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
2230 Catalase CAT 0.0006
3249 Catalase katA 0.0006
3625 Catalase katA 0.0006
4539 Catalase katA 0.0006
4941 Catalase katB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
358 Cystathionine beta-synthase CBS 0.0004
693 Hemoglobin subunit beta HBB 0.0004
2802 Endoglucanase G celCCG 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
↑