DT-Web: DB00471

Identification

Name

Montelukast

Accession Number

DB00471 (APRD00434)

Type

small molecule

Description

Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation. Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific locus of operation, it does not interact with other allergy medications such as theophylline. Montelukast is marketed in United States and many other countries by Merck & Co. with the brand name Singulair(R). It is available as oral tablets, chewable tablets, and oral granules. In India and other countries, it is also marketed under the brand name Montair®, produced by Indian company Cipla.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

586.183

Groups

approved

Monoisotopic Weight

585.21044242

Pharmacology

Indication

For the treatment of asthma

Mechanism of action

Montelukast selectively antagonizes leukotriene D₄ (LTD₄) at the cysteinyl leukotriene receptor, CysLT₁, in the human airway. Montelukast inhibits the actions of LTD₄ at the CysLT₁ receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.

Absorption

Rapidly absorbed following oral administration (bioavailability is 64%)

Protein binding

99% (to plasma proteins)

Biotransformation

Hepatic

Route of elimination

Coupled with estimates of montelukast oral bioavailability, this indicates that montelukast and its metabolites are excreted almost exclusively via the bile.

Toxicity

Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Tolbutamide	Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Montelukast. Consider alternate therapy or monitor for changes in Montelukast therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.

Food Interactions

Take without regard to meals.

Cysteinyl leukotriene receptor 1
Name	Cysteinyl leukotriene receptor 1
Gene Name	CYSLTR1
Pharmacological action	yes
Actions	antagonist
References	Nayak A: A review of montelukast in the treatment of asthma and allergic rhinitis. Expert Opin Pharmacother. 2004 Mar;5(3):679-86. - Pubmed Zhang YJ, Zhang L, Wang SB, Shen HH, Wei EQ: Montelukast modulates lung CysLT(1) receptor expression and eosinophilic inflammation in asthmatic mice. Acta Pharmacol Sin. 2004 Oct;25(10):1341-6. - Pubmed Hamacher J, Eichert K, Braun C, Grebe T, Strub A, Lucas R, Eltze M, Wendel A: Montelukast exerts no acute direct effect on NO synthases. Pulm Pharmacol Ther. 2007;20(5):525-33. Epub 2006 May 19. - Pubmed Langlois A, Ferland C, Tremblay GM, Laviolette M: Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism. J Allergy Clin Immunol. 2006 Jul;118(1):113-9. Epub 2006 May 19. - Pubmed Alfieri AB, Tramontana M, Cialdai C, Lecci A, Giuliani S, Crea A, Manzini S, Maggi CA: Heterogeneous effect of leucotriene CysLT1 receptor antagonists on antigen-induced motor and inflammatory responses in guinea-pig airways. Auton Autacoid Pharmacol. 2007 Jan;27(1):39-46. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.4975
Arachidonate 5-lipoxygenase
Name	Arachidonate 5-lipoxygenase
Gene Name	ALOX5
Pharmacological action	unknown
Actions	other/unknown
References	Ramires R, Caiaffa MF, Tursi A, Haeggstrom JZ, Macchia L: Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast. Biochem Biophys Res Commun. 2004 Nov 12;324(2):815-21. - Pubmed
DTHybrid score	0.313

Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Schoch GA, Yano JK, Sansen S, Dansette PM, Stout CD, Johnson EF: Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J Biol Chem. 2008 Jun 20;283(25):17227-37. Epub 2008 Apr 15. - Pubmed Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3392
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5101
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.4795
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5688
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.306

Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions	substrate
References	Mougey EB, Feng H, Castro M, Irvin CG, Lima JJ: Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response. Pharmacogenet Genomics. 2009 Feb;19(2):129-38. - Pubmed
DTHybrid score	0.224

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.2428
290	Prostaglandin G/H synthase 2	PTGS2	0.23
4119	Cytochrome P450 2D6	CYP2D6	0.2187
4200	Cytochrome P450 1A2	CYP1A2	0.201
1588	Multidrug resistance protein 1	ABCB1	0.1715
4118	Cytochrome P450 3A5	CYP3A5	0.1436
6013	Cytochrome P450 2E1	CYP2E1	0.1384
6030	Cytochrome P450 2B6	CYP2B6	0.1372
6107	Cytochrome P450 3A7	CYP3A7	0.0961
587	Serum albumin	ALB	0.096
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0886
1729	Solute carrier family 22 member 6	SLC22A6	0.0867
6024	Cytochrome P450 1A1	CYP1A1	0.0865
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0795
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0789
111	Cysteinyl leukotriene receptor 2	CYSLTR2	0.0672
1448	fMet-Leu-Phe receptor	FPR1	0.0671
325	Prostaglandin D2 receptor	PTGDR	0.067
6106	Cytochrome P450 2C18	CYP2C18	0.0595
6142	Solute carrier family 22 member 8	SLC22A8	0.0593
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0586
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0585
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0585
6182	Cytochrome P450 2J2	CYP2J2	0.0578
738	Monocarboxylate transporter 1	SLC16A1	0.049
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0485
862	Multidrug resistance-associated protein 1	ABCC1	0.0483
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0448
1757	Myeloperoxidase	MPO	0.0439
2164	Multidrug resistance-associated protein 4	ABCC4	0.0436
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0433
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0424
3811	Cytochrome P450 19A1	CYP19A1	0.0398
2232	Interleukin-5	IL5	0.0397
1593	Mucin-2	MUC2	0.0395
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0394
1024	Solute carrier family 22 member 11	SLC22A11	0.0394
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0369
492	Histamine H1 receptor	HRH1	0.0367
703	NADPH azoreductase	azr	0.0352
6143	Solute carrier family 22 member 7	SLC22A7	0.0344
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0336
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0328
777	Tumor necrosis factor	TNF	0.0326
136	Estrogen receptor	ESR1	0.0321
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0316
776	Bile salt export pump	ABCB11	0.0314
3923	Cholinesterase	BCHE	0.0312
6145	Solute carrier family 22 member 1	SLC22A1	0.0309
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0304
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0304
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0304
1123	Eosinophil cationic protein	RNASE3	0.0299
1898	Cytochrome P450 1B1	CYP1B1	0.0295
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0293
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0288
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0282
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0275
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0256
871	Glucocorticoid receptor	NR3C1	0.0249
118	Organic cation/carnitine transporter 2	SLC22A5	0.0244
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0235
824	Sodium-dependent serotonin transporter	SLC6A4	0.0233
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0228
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0226
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0226
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0223
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0222
6144	Solute carrier family 22 member 2	SLC22A2	0.0217
556	Alpha-1A adrenergic receptor	ADRA1A	0.0215
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0214
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0208
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0206
6136	Multidrug resistance-associated protein 5	ABCC5	0.0206
468	Cytochrome P450 4A11	CYP4A11	0.0206
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0203
891	Dihydropteroate synthase	folP	0.0203
5359	Dihydropteroate synthase	folP	0.0203
7175	Dihydropteroate synthase	sulI	0.0203
1507	Cytochrome c	CYCS	0.0201
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0201
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0198
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0193
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0192
6102	Arylamine N-acetyltransferase 2	NAT2	0.019
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0188
847	Mu-type opioid receptor	OPRM1	0.0187
318	Alpha-2A adrenergic receptor	ADRA2A	0.0187
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0185
260	Cytochrome P450 51	ERG11	0.0179
761	Cytochrome P450 51	ERG11	0.0179
3163	Cytochrome P450 51	cyp51	0.0179
467	Delta-type opioid receptor	OPRD1	0.0178
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0176
766	Beta-2 adrenergic receptor	ADRB2	0.0176
6014	Cytochrome P450 2A13	CYP2A13	0.0175
70	Type-1 angiotensin II receptor	AGTR1	0.0174
831	D(2) dopamine receptor	DRD2	0.0173
672	Prostaglandin F2-alpha receptor	PTGFR	0.0171
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0171
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0171
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.017
341	5-hydroxytryptamine 3 receptor	HTR3A	0.017
6031	Cytochrome P450 3A43	CYP3A43	0.017
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0168
696	Kappa-type opioid receptor	OPRK1	0.0167
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0165
731	HIV-1 protease	HIV-1 protease	0.0163
33	Cystine/glutamate transporter	SLC7A11	0.0161
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0158
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0158
811	Translocator protein	TSPO	0.0154
373	Transthyretin	TTR	0.0153
6141	Sodium/bile acid cotransporter	SLC10A1	0.0152
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0151
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0147
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0146
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0144
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0142
713	Sodium-dependent dopamine transporter	SLC6A3	0.0141
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0141
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.014
6085	Fatty acid-binding protein, intestinal	FABP2	0.0135
122	P2Y purinoceptor 12	P2RY12	0.0134
3941	Amine oxidase [flavin-containing] A	MAOA	0.0133
6147	Solute carrier family 22 member 3	SLC22A3	0.0133
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0129
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0129
146	Androgen receptor	AR	0.0127
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0126
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0126
183	Vascular endothelial growth factor A	VEGFA	0.0125
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0125
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0123
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0122
489	Monocarboxylate transporter 2	SLC16A7	0.0122
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0122
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0118
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0118
1650	Heme carrier protein 1	SLC46A1	0.0116
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0115
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0115
3939	Amine oxidase [flavin-containing] B	MAOB	0.0113
232	Corticosteroid-binding globulin	SERPINA6	0.0113
500	Monocarboxylate transporter 4	SLC16A3	0.0111
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.011
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.011
3932	Glutathione S-transferase A2	GSTA2	0.011
833	Organic cation/carnitine transporter 1	SLC22A4	0.0109
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0109
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0108
465	Calmodulin	CALM1	0.0107
6167	Organic solute transporter subunit beta	OSTB	0.0107
6166	Organic solute transporter subunit alpha	OSTA	0.0106
632	Alpha-1B adrenergic receptor	ADRA1B	0.0105
6149	Solute carrier family 22 member 10	SLC22A10	0.0105
614	Progesterone receptor	PGR	0.0105
23	D(1A) dopamine receptor	DRD1	0.0103
140	30S ribosomal protein S9	rpsI	0.0103
6719	30S ribosomal protein S9	rpsI	0.0103
6725	30S ribosomal protein S9	rpsI	0.0103
869	Estrogen receptor beta	ESR2	0.0103
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0102
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0102
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0101
1654	Interleukin-1 beta	IL1B	0.01
6148	Multidrug resistance-associated protein 7	ABCC10	0.0098
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0098
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0098
68	Cannabinoid receptor 1	CNR1	0.0098
5650	NimA-related protein	DR_0842	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
527	Prostacyclin receptor	PTGIR	0.0097
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0095
1792	Tissue-type plasminogen activator	PLAT	0.0095
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0094
817	DNA topoisomerase 2-alpha	TOP2A	0.0093
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0093
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0093
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0092
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0091
3810	Catechol O-methyltransferase	COMT	0.0091
4237	50S ribosomal protein L22	rplV	0.009
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.009
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0088
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0088
3312	Fatty acid-binding protein, brain	FABP7	0.0086
952	Dipeptidyl peptidase 4	DPP4	0.0085
380	Cytochrome P450 17A1	CYP17A1	0.0085
22	30S ribosomal protein S4	rpsD	0.0084
6714	30S ribosomal protein S4	rpsD	0.0084
2230	Catalase	CAT	0.0084
3249	Catalase	katA	0.0084
3625	Catalase	katA	0.0084
4539	Catalase	katA	0.0084
4941	Catalase	katB	0.0084
844	Epidermal growth factor receptor	EGFR	0.0084
494	Caspase-1	CASP1	0.0083
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0083
504	Mast/stem cell growth factor receptor	KIT	0.0083
4604	Liver carboxylesterase 1	CES1	0.0082
185	Vasopressin V1a receptor	AVPR1A	0.0082
427	Substance-P receptor	TACR1	0.0082
29	Tubulin beta-1 chain	TUBB1	0.0081
6137	Multidrug resistance-associated protein 6	ABCC6	0.0081
1648	Elastin	ELN	0.0081
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0081
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.008
322	Vasopressin V2 receptor	AVPR2	0.008
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0079
482	Glycine receptor subunit alpha-1	GLRA1	0.0079
518	Peroxidase/catalase T	katG	0.0079
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0079
789	Alpha-1D adrenergic receptor	ADRA1D	0.0079
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0078
860	Nicotinamide N-methyltransferase	NNMT	0.0078
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0078
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
699	Nicotinic acid receptor 1	GPR109A	0.0078
928	Nicotinic acid receptor 2	GPR109B	0.0078
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0078
295	Carbonic anhydrase 1	CA1	0.0077
365	Dihydrofolate reductase	DHFR	0.0077
2381	Dihydrofolate reductase	DFR1	0.0077
2833	Dihydrofolate reductase	Not Available	0.0077
2931	Dihydrofolate reductase	folA	0.0077
3544	Dihydrofolate reductase	folA	0.0077
3682	Dihydrofolate reductase	folA	0.0077
6642	Dihydrofolate reductase	folA	0.0077
6756	Dihydrofolate reductase	dfrA	0.0077
4238	50S ribosomal protein L4	rplD	0.0077
5578	50S ribosomal protein L4	rplD	0.0077
6173	50S ribosomal protein L4	rplD	0.0077
6219	50S ribosomal protein L4	rplD	0.0077
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0077
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0076
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0076
86	SEC14-like protein 4	SEC14L4	0.0075
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.0075
375	SEC14-like protein 3	SEC14L3	0.0075
4076	Diacylglycerol kinase alpha	DGKA	0.0075
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0074
283	SEC14-like protein 2	SEC14L2	0.0074
716	5-hydroxytryptamine 7 receptor	HTR7	0.0074
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0074
1541	Metalloproteinase	mmp20	0.0074
756	Sex hormone-binding globulin	SHBG	0.0074
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0074
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0073
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0073
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0073
106	Cannabinoid receptor 2	CNR2	0.0072
7	Nitric oxide synthase, inducible	NOS2	0.0072
130	Prostacyclin synthase	PTGIS	0.0072
94	5-hydroxytryptamine 4 receptor	HTR4	0.0072
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0071
1275	Estrogen sulfotransferase	SULT1E1	0.0071
921	Glutamate receptor 2	GRIA2	0.007
6220	Aryl hydrocarbon receptor	AHR	0.007
558	Solute carrier family 12 member 1	SLC12A1	0.007
2077	Caspase-3	CASP3	0.0069
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0069
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0069
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0069
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0069
49	Endothelin B receptor	EDNRB	0.0069
705	Glutamate receptor 1	GRIA1	0.0069
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0069
88	Retinoic acid receptor RXR-beta	RXRB	0.0068
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0068
65	Matrix metalloproteinase-9	Not Available	0.0068
1050	Bile salt sulfotransferase	SULT2A1	0.0068
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0068
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0068
904	Glutathione S-transferase P	GSTP1	0.0068
638	D(3) dopamine receptor	DRD3	0.0067
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0067
284	DNA-directed RNA polymerase beta chain	rpoB	0.0067
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0067
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0067
407	Vascular endothelial growth factor receptor 2	KDR	0.0067
592	Carbonic anhydrase 4	CA4	0.0067
629	Alpha-2B adrenergic receptor	ADRA2B	0.0066
24	Thymidylate synthase	TMP1	0.0066
359	Thymidylate synthase	TYMS	0.0066
2626	Thymidylate synthase	thyA	0.0066
2729	Thymidylate synthase	thyA	0.0066
5352	Thymidylate synthase	THYA	0.0066
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0066
6043	Putative G-protein coupled receptor 44	GPR44	0.0065
708	Alpha-tocopherol transfer protein	TTPA	0.0065
6103	Arylamine N-acetyltransferase 1	NAT1	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
193	Beta-1 adrenergic receptor	ADRB1	0.0065
1192	Sulfotransferase 1A1	SULT1A1	0.0065
737	Mineralocorticoid receptor	NR3C2	0.0064
1629	Transcription factor AP-1	JUN	0.0064
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0064
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0063
905	Glutathione transferase omega-1	GSTO1	0.0063
899	Glutathione S-transferase Mu 3	GSTM3	0.0063
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0063
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0063
133	Dihydropterate synthase	sulI	0.0063
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0063
6174	50S ribosomal protein L32	rpmF	0.0062
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0062
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
1010	Cytochrome P450 51A1	CYP51A1	0.0062
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0061
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.0061
810	Heme oxygenase 1	HMOX1	0.006
3391	Heme oxygenase 1	pbsA1	0.006
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.006
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0059
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0059
997	Protein kinase C beta type	PRKCB	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
6020	Aldehyde oxidase	AOX1	0.0058
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0058
818	50S ribosomal protein L10	rplJ	0.0058
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0058
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0058
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0058
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0057
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0057
2021	Thrombomodulin	THBD	0.0057
273	Apoptosis regulator Bcl-2	BCL2	0.0055
1970	Protein kinase C alpha type	PRKCA	0.0055
378	Alpha-2C adrenergic receptor	ADRA2C	0.0055
4120	NADPH--cytochrome P450 reductase	POR	0.0055
251	Alcohol dehydrogenase 1A	ADH1A	0.0055
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0055
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0053
84	Nuclear receptor 0B1	NR0B1	0.0053
850	Vasopressin V1b receptor	AVPR1B	0.0053
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0052
161	Tubulin beta chain	TUBB	0.0052
312	Tubulin beta chain	TUB2	0.0052
6837	Serine/threonine-protein kinase 17B	STK17B	0.0052
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0052
780	Retinoic acid receptor RXR-gamma	RXRG	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0051
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0051
3809	Estrogen-related receptor gamma	ESRRG	0.0051
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0051
723	Cytosolic phospholipase A2	PLA2G4A	0.005
823	Fibroblast growth factor receptor 2	FGFR2	0.005
459	Retinoic acid receptor RXR-alpha	RXRA	0.005
634	Squalene monooxygenase	SQLE	0.005
7196	Squalene monooxygenase	ERG1	0.005
357	Carbonic anhydrase 2	CA2	0.005
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.005
3947	Xanthine dehydrogenase/oxidase	XDH	0.0049
432	D(4) dopamine receptor	DRD4	0.0049
6033	High affinity interleukin-8 receptor A	CXCR1	0.0049
444	Alcohol dehydrogenase 1B	ADH1B	0.0049
6151	Monocarboxylate transporter 10	SLC16A10	0.0049
856	Vitamin D3 receptor	VDR	0.0049
814	Ryanodine receptor 1	RYR1	0.0048
2298	Cytochrome P450-cam	camC	0.0048
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0048
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0048
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0047
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0047
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0047
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0046
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0046
2599	Tyrosine-protein kinase HCK	HCK	0.0046
3014	Ribonuclease UK114	HRSP12	0.0046
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0046
5428	Replication protein	repA	0.0046
3617	Non-heme chloroperoxidase	cpo	0.0046
5426	Non-heme chloroperoxidase	cpo	0.0046
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0046
26	Vascular endothelial growth factor receptor 3	FLT4	0.0046
3018	HTH-type transcriptional regulator malT	malT	0.0046
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0045
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0045
563	Thyroid peroxidase	TPO	0.0045
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0045
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0045
474	Acetylcholinesterase	ACHE	0.0045
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0045
54	Prothrombin	F2	0.0044
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
32	Vascular endothelial growth factor receptor 1	FLT1	0.0044
3808	Dihydropteroate synthase 2	folP2	0.0044
3601	Dihydropteroate synthase 1	folP1	0.0044
3807	Dihydropteroate synthase 1	folP1	0.0044
162	Retinoic acid receptor gamma-1	RARG	0.0043
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0043
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0043
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0042
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0042
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0042
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0042
517	Alcohol dehydrogenase 1C	ADH1C	0.0042
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0042
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
2958	Probable tautomerase ydcE	pptA	0.004
2573	Cocaine esterase	cocE	0.004
7263	Cocaine esterase	Not Available	0.004
6138	Multidrug resistance protein 3	ABCB4	0.0039
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0039
4217	Telomerase reverse transcriptase	TERT	0.0039
3639	Thymidine phosphorylase	deoA	0.0039
3936	Thymidine phosphorylase	TYMP	0.0039
3115	Ras-related protein Rab-9	RAB9A	0.0039
2207	Rhodopsin	RHO	0.0039
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
477	DNA topoisomerase 4 subunit A	parC	0.0038
886	DNA topoisomerase 4 subunit A	parC	0.0038
6226	DNA topoisomerase 4 subunit A	parC	0.0038
6126	Carbonic anhydrase 7	CA7	0.0038
404	DNA gyrase subunit A	gyrA	0.0038
6224	DNA gyrase subunit A	gyrA	0.0038
1618	High affinity nerve growth factor receptor	NTRK1	0.0037
469	Annexin A1	ANXA1	0.0037
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0037
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0037
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0037
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0037
6146	High affinity copper uptake protein 1	SLC31A1	0.0037
4103	Proteasome subunit beta type 2	PSMB2	0.0037
4102	Proteasome subunit beta type 5	PSMB5	0.0037
4101	Proteasome subunit beta type 1	PSMB1	0.0037
1039	Histone deacetylase 9	HDAC9	0.0037
4122	Histone deacetylase 2	HDAC2	0.0037
1656	CYP2B protein	CYP2B	0.0036
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0036
239	Coagulation factor X	F10	0.0036
16	Adenosine A1 receptor	ADORA1	0.0036
1636	Trace amine-associated receptor 1	TAAR1	0.0036
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0036
4226	Uridine phosphorylase 2	UPP2	0.0035
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0035
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0035
131	Synaptic vesicular amine transporter	SLC18A2	0.0035
2539	Tubulin alpha-1 chain	TUBA4A	0.0035
1178	Adenosine A2a receptor	ADORA2A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0035
124	Histamine H2 receptor	HRH2	0.0034
719	Retinoic acid receptor responder protein 1	RARRES1	0.0034
770	Retinoic acid-induced protein 3	GPRC5A	0.0034
1483	Membrane copper amine oxidase	AOC3	0.0034
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0034
5300	Antigen peptide transporter 1	TAP1	0.0034
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0034
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0034
581	Cytochrome P450 2R1	CYP2R1	0.0034
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0033
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0033
4225	Uridine phosphorylase 1	UPP1	0.0032
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0032
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
4992	Cytochrome c peroxidase	Not Available	0.0032
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0032
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0032
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0031
1196	Complement decay-accelerating factor	CD55	0.0031
3086	Plasmepsin-2	Not Available	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
2320	Thymidine kinase, cytosolic	TK1	0.003
1256	5-hydroxytryptamine 6 receptor	HTR6	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
413	Amidophosphoribosyltransferase	PPAT	0.003
2515	Amidophosphoribosyltransferase	purF	0.003
3714	Amidophosphoribosyltransferase	purF	0.003
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.003
2693	Heat-labile enterotoxin B chain	eltB	0.003
569	Retinal dehydrogenase 2	ALDH1A2	0.003
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.003
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.003
132	ATP-binding cassette sub-family A member 1	ABCA1	0.003
164	Histamine H4 receptor	HRH4	0.003
6645	D-amino-acid oxidase	DAO	0.0029
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0029
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0029
3937	Fatty-acid amide hydrolase	FAAH	0.0029
153	Dopamine beta-hydroxylase	DBH	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
611	Retinal dehydrogenase 1	ALDH1A1	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0028
1852	Microtubule-associated protein 2	MAP2	0.0028
6131	Carbonic anhydrase 14	CA14	0.0027
2808	Chloramphenicol acetyltransferase 3	cat3	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
5787	Angiopoietin-1 receptor	TEK	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0027
5934	Cytochrome P450 26A1	CYP26A1	0.0027
4943	Cytochrome c6	petJ	0.0027
4934	Cytochrome c-551	nirM	0.0027
5218	Cytochrome c-551	nirM	0.0027
4905	Cytochrome c2	Not Available	0.0027
4939	Cytochrome c2	cycA	0.0027
4964	Cytochrome c2	cycA	0.0027
4979	Cytochrome c2	cycA	0.0027
6673	Cytochrome c2	cycA	0.0027
4947	Bacterial hemoglobin	vhb	0.0027
4916	Cyanoglobin	glbN	0.0027
4954	Soluble cytochrome b558	Not Available	0.0027
4994	Hemoglobin-like protein HbO	glbO	0.0027
4975	Cytochrome c-556	RPA3973	0.0027
4909	CooA protein	cooA	0.0027
4942	Diheme cytochrome c napB	napB	0.0027
4915	Cytochrome c-550	psbV	0.0027
4959	Cytochrome c-550	psbV	0.0027
5216	Cytochrome c-550	psbV	0.0027
4925	Cytochrome c-type protein SHP	shp	0.0027
3116	Bacterioferritin	bfr	0.0027
4906	Bacterioferritin	bfr	0.0027
4965	Bacterioferritin	bfr	0.0027
4936	Cytochrome c2 iso-2	Not Available	0.0027
4981	Iron-starvation protein PigA	pigA	0.0027
4907	Cytochrome c-L	moxG	0.0027
6865	Cytochrome c-L	moxG	0.0027
4998	Hemoglobin-like protein yjbI	yjbI	0.0027
4984	Neuroglobin	NGB	0.0027
5000	HemO	hemO	0.0027
4989	Cytochrome c551 peroxidase	ccp	0.0027
5222	Cytochrome c551 peroxidase	ccpA	0.0027
644	Heme oxygenase 2	HMOX2	0.0027
4982	Heme oxygenase 2	pbsA2	0.0027
4935	Cytochrome c-554	cycA1	0.0027
4961	Hemophore HasA	hasA	0.0027
4999	Cytochrome P450 165B3	CYP165B3	0.0027
4764	Cytochrome P450 165C4	CYP165C4	0.0027
4971	Nonaheme cytochrome c	hmcA	0.0027
4904	Cytochrome c family protein	GSU1996	0.0027
4910	Cytoglobin	CYGB	0.0027
4976	Apocytochrome f	petA	0.0027
6407	Apocytochrome f	petA	0.0027
4937	Cytochrome oxidase subunit II	rcoxA	0.0027
4931	Cytochrome P450 167A1	CYP167A1	0.0027
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0027
4960	Putative cytochrome P450-family protein	SCO7417	0.0027
4903	Methyl-accepting chemotaxis protein	Tar4	0.0027
4972	P450cin	cinA	0.0027
163	D(1B) dopamine receptor	DRD5	0.0027
4922	Cytochrome c, putative	SO_4144	0.0027
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0027
4952	Catalase/peroxidase	katA	0.0027
4993	Hydroxylamine oxidoreductase	hao1	0.0027
3093	Catalase HPII	katE	0.0027
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0027
6500	Phospholipase A2	PLA2G1B	0.0026
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0026
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0026
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0026
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0026
1714	Mitogen-activated protein kinase 3	MAPK3	0.0026
1374	Natriuretic peptides B	NPPB	0.0026
1827	Gap junction alpha-1 protein	GJA1	0.0026
1908	Vascular cell adhesion protein 1	VCAM1	0.0026
3856	Fibroblast growth factor receptor 3	FGFR3	0.0026
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0026
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0026
4948	Cytochrome c-553	Not Available	0.0025
4923	Cytochrome c3	DvMF_2499	0.0025
4945	Cytochrome c3	Not Available	0.0025
4949	Cytochrome c3	DVU_3171	0.0025
4968	Cytochrome c3	cytc3	0.0025
4997	Cytochrome c3	SO_2727	0.0025
5219	Cytochrome c3	cyd	0.0025
4902	Nine-heme cytochrome c	Ddes_2038	0.0025
3189	High-molecular-weight cytochrome c	hmcA	0.0025
165	FL cytokine receptor	FLT3	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
2417	Chloramphenicol acetyltransferase	cat	0.0025
3278	Chloramphenicol acetyltransferase	cat	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
2810	Dr hemagglutinin structural subunit	draA	0.0025
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0025
3587	Gastrotropin	FABP6	0.0025
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0025
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0024
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0024
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
759	Free fatty acid receptor 1	FFAR1	0.0024
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
2112	Toll-like receptor 9	TLR9	0.0024
229	Retinoic acid receptor beta	RARB	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0023
730	Retinoic acid receptor alpha	RARA	0.0023
4192	DNA topoisomerase 2-beta	TOP2B	0.0023
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0023
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0023
2236	Casein kinase II subunit alpha	CSNK2A1	0.0023
908	Glutathione S-transferase theta-1	GSTT1	0.0022
4311	tRNA	TRDMT1	0.0022
4325	tRNA	trmD	0.0022
4328	tRNA	trmD	0.0022
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
1992	Vitamin D-binding protein	GC	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
822	Aldose reductase	AKR1B1	0.0022
319	Opioid receptor, sigma 1	OPRS1	0.0022
4386	Hemoglobin-like protein HbN	glbN	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0022
1268	Neuropeptide S receptor	NPSR1	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0021
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0021
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0021
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0021
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0021
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0021
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0021
1053	BC269730_2	FADS1	0.0021
1395	Sodium/calcium exchanger 1	SLC8A1	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
976	Platelet glycoprotein IX	GP9	0.0021
1630	Integrin beta-2	ITGB2	0.0021
291	Nitric-oxide synthase, endothelial	NOS3	0.002
594	Thyroxine-binding globulin	SERPINA7	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
400	Coagulation factor IX	F9	0.002
5461	Coagulation factor IX	F9	0.002
4920	Peroxidase/catalase	katG	0.002
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.002
3221	Cytochrome c4	cc4	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
1864	RET proto-oncogene	RET	0.0019
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0019
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0019
2119	Cytochrome b5	CYB5A	0.0019
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0019
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0019
4037	Hypothetical protein	GPX1	0.0019
4297	Hypothetical protein	SP_1951	0.0019
4521	Hypothetical protein	BC_2969	0.0019
4540	Hypothetical protein	TM_1070	0.0019
4555	Hypothetical protein	MT1739	0.0019
4569	Hypothetical protein	mshD	0.0019
4578	Hypothetical protein	PA3270	0.0019
4747	Hypothetical protein	PA3967	0.0019
5177	Hypothetical protein	TM_0096	0.0019
5194	Hypothetical protein	PA1204	0.0019
5240	Hypothetical protein	Rv2991	0.0019
5370	Hypothetical protein	TM_1158	0.0019
5710	Hypothetical protein	Tb927.5.1360	0.0019
4990	PpcA	ppcA	0.0019
5923	Microtubule-associated protein tau	MAPT	0.0019
5924	Microtubule-associated protein 4	MAP4	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
3570	Cytochrome P450 152A1	cypC	0.0019
4289	Cytochrome P450	TT_P0059	0.0019
6262	Cytochrome P450	staP	0.0019
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0019
4988	Sulfite oxidase, mitochondrial	SUOX	0.0019
2915	Sensor protein fixL	fixL	0.0019
4944	Sensor protein fixL	fixL	0.0019
1291	cAMP response element-binding protein	CREB1	0.0019
3375	Acidic cytochrome c3	Not Available	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
4385	Cytochrome c'	Not Available	0.0019
4967	Cytochrome c'	cycA	0.0019
5038	Cytochrome c'	Not Available	0.0019
5223	Cytochrome c'	cycP	0.0019
4813	Heme oxygenase	hmuO	0.0019
5769	Heme oxygenase	Not Available	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
174	Sigma 1-type opioid receptor	SIGMAR1	0.0018
4210	Toll-like receptor 4	TLR4	0.0018
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0018
604	Vitamin K-dependent protein Z	PROZ	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
1262	Corticotropin-lipotropin	POMC	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
6048	Troponin C, skeletal muscle	TNNC2	0.0018
683	Potassium transporter	GK0582	0.0018
199	Monocarboxylate transporter 8	SLC16A2	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
268	Adenosine A2b receptor	ADORA2B	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0017
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0017
3670	Soluble cytochrome b562 precursor	cybC	0.0017
3411	Cytochrome P450 121	cyp121	0.0017
6044	Serum paraoxonase/lactonase 3	PON3	0.0017
6824	Tyrosine-protein kinase Lyn	LYN	0.0017
4773	Deoxycytidine kinase	DCK	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
2617	Nitric oxide synthase oxygenase	nos	0.0017
2701	Nitric oxide synthase oxygenase	nos	0.0017
6432	Transporter	snf	0.0017
3291	Cytochrome c-552	cycA	0.0017
4927	Cytochrome c-552	nrfA	0.0017
4938	Cytochrome c-552	cycA	0.0017
4953	Cytochrome c-552	nrfA	0.0017
5217	Cytochrome c-552	cycM	0.0017
1245	Vitamin K-dependent protein S	PROS1	0.0017
422	Vitamin K-dependent protein C	PROC	0.0017
3102	Flavohemoprotein	hmp	0.0017
4969	Flavohemoprotein	hmp	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0016
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
572	Integrin alpha-L	ITGAL	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0016
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0016
5798	Mitogen-activated protein kinase 11	MAPK11	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
936	Ephrin type-A receptor 2	EPHA2	0.0015
267	Plasminogen activator inhibitor 1	SERPINE1	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0015
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0015
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0015
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0015
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0015
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0015
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
4608	Putative cytochrome P450	SCO1207	0.0014
4963	Putative cytochrome P450	SCO2884	0.0014
6254	Putative cytochrome P450	SCO6998	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
6221	Steroid hormone receptor ERR1	ESRRA	0.0014
6218	Pannexin-1	PANX1	0.0014
358	Cystathionine beta-synthase	CBS	0.0014
76	Nitric-oxide synthase, brain	NOS1	0.0014
798	Osteocalcin	BGLAP	0.0014
751	Potassium channel subfamily K member 6	KCNK6	0.0013
6042	Prostaglandin reductase 2	PTGR2	0.0013
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0013
2216	Fibroblast growth factor receptor 4	FGFR4	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
3904	Alanine aminotransferase 2	GPT2	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
693	Hemoglobin subunit beta	HBB	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
172	Potassium channel subfamily K member 1	KCNK1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
369	Coagulation factor VII	F7	0.0012
5590	N utilization substance protein B homolog	nusB	0.0012
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0012
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0012
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0012
2300	Lysozyme	E	0.0012
3633	Lysozyme	R	0.0012
5597	Lysozyme	17	0.0012
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0012
2838	Ribose-5-phosphate isomerase A	rpiA	0.0012
2952	Ribose-5-phosphate isomerase A	rpiA	0.0012
5595	Ribose-5-phosphate isomerase A	rpiA	0.0012
4695	UPF0124 protein yfiH	yfiH	0.0012
5060	Intron-associated endonuclease 1	ITEVIR	0.0012
5593	Transferase	Not Available	0.0012
5588	Cell division protein FtsY	TM_0570	0.0012
5591	Complement component C8 gamma chain	C8G	0.0012
5587	Iron(III)-binding periplasmic protein	fbpA	0.0012
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0012
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0012
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0012
5581	Beta-fructosidase	bfrA	0.0012
5600	Pyruvate decarboxylase	pdc	0.0012
4375	Glutamine synthetase 1	glnA1	0.0012
5575	Short tail fiber protein	12	0.0012
5580	Hexon protein	PII	0.0012
5574	Invasin	YPTB1668	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0012
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0012
6268	Hydroxyacid oxidase 1	HAO1	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
3957	Adenosine deaminase	ADA	0.0011
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
5006	RNASE4 protein	RNASE4	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
5328	Prostaglandin F synthase	Tb11.02.2310	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
3729	Citrate synthase	gltA	0.0011
4575	Citrate synthase	cit	0.0011
4580	Citrate synthase	gltA	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
1313	Lactoylglutathione lyase	GLO1	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.001
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.001
5251	Carbonyl reductase [NADPH] 1	CBR1	0.001
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.001
2603	Beta-lactamase II	blm	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
2149	Angiogenin	ANG	0.001
3583	6-phosphogluconolactonase	pgl	0.001
857	Malate dehydrogenase, mitochondrial	MDH2	0.001
760	Fibroblast growth factor 1	FGF1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6459	Glycodelin	PAEP	0.0009
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
2942	Sialidase	nanH	0.0009
3546	Sialidase	nedA	0.0009
3486	Fumarate hydratase class II	fumC	0.0009
1517	Beta-3 adrenergic receptor	ADRB3	0.0009
332	Beta-lactamase	blaZ	0.0009
2478	Beta-lactamase	ampC	0.0009
2613	Beta-lactamase	ampC	0.0009
2635	Beta-lactamase	ampC	0.0009
2700	Beta-lactamase	penP	0.0009
5445	Beta-lactamase	blaB	0.0009
6019	Beta-lactamase	SHV-7	0.0009
6701	Beta-lactamase	cphA	0.0009
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0009
2286	Isocitrate dehydrogenase [NADP]	icd	0.0009
2302	Isocitrate dehydrogenase [NADP]	icd	0.0009
2771	Isocitrate dehydrogenase [NADP]	icd	0.0009
820	Glycine receptor subunit alpha-2	GLRA2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
2697	Uridine-cytidine kinase 2	UCK2	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
6677	Myelin P2 protein	PMP2	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
411	Glycine N-methyltransferase	GNMT	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
1184	Interferon beta	IFNB1	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
1867	Major prion protein	PRNP	0.0008
128	Adenine phosphoribosyltransferase	APRT	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
3830	Calreticulin	CALR	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
125	DNA polymerase beta	POLB	0.0007
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
442	Envelope glycoprotein	gp41	0.0006
4859	Envelope glycoprotein	env	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
5682	Ribonuclease pancreatic	RNASE1	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2430	Chondroitinase B	cslB	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
958	Insulin-like growth factor 1 receptor	IGF1R	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
1243	Cathepsin D	CTSD	0.0003
1439	Lactotransferrin	LTF	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00471 - Montelukast

Targets

Enzymes

Transporters

Predictions