DT-Web

DB00921 - Buprenorphine


Identification
Name Buprenorphine
Accession Number DB00921 (APRD00670)
Type small molecule
Description Buprenorphine is a derivative of the opioid alkaloid thebaine that is a more potent (25 - 40 times) and longer lasting analgesic than morphine. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 467.6401
Groups illicit
Monoisotopic Weight 467.303558805
Pharmacology
Indication For the treatment of moderate to severe pain, peri-operative analgesia, and opioid dependence.
Mechanism of action Buprenorphine's analgesic effect is due to partial agonist activity at mu-opioid receptors. Buprenorphine is also a kappa-opioid receptor antagonist. The partial agonist activity means that opioid receptor antagonists (e.g., an antidote such as naloxone) only partially reverse the effects of buprenorphine. The binding to the mu and kappa receptors results in hyperpolarization and reduced neuronal excitability. Furthermore, buprenorphine slowly dissociates from its receptor. This observation would account for the longer duration of action compared to morphine, the unpredictability of its reversal by opioid antagonists, and its low level of manifest physical dependence. Its receptor fixation half life is 40 minutes which is significantly longer than morphine (milliseconds).
Absorption 31% bioavailability (sublingual). Sublingual absorption is also dependent on pH. The length of time the tablet is under the tongue has little effect on absorption. Although buprenorphine is rapidly absorbed from the oral mucosa, the absorption into the systemic is slower. The time to reach peak plasma concentration (Tmax) varies between individuals (range of 40 minutes to 3.5 hours). How buprenorphine is formulated does not affect this pharmacokinetic parameter. It also undergoes extensive first-pass metabolism and as a consequence, has very low oral bioavailability. Coadministration with naloxone does not effect the pharmacokinetics of buprenorphine.
Protein binding 96% protein bound to alpha- and beta-globulin.
Biotransformation Hepatic. Buprenorphine undergoes both N-dealkylation to norbuprenorphine and glucuronidation. The N-dealkylation pathway is mediated by cytochrome P-450 3A4 isozyme. Norbuprenorphine, an active metabolite and has one-fifth of the pharmacologic activity of the parent compound, can further undergo glucuronidation.
Route of elimination Buprenorphine, like morphine and other phenolic opioid analgesics, is metabolized by the liver and its clearance is related to hepatic blood flow. It is primarily eliminated via feces (as free forms of buprenorphine and norbuprenorphine) while 10 - 30% of the dose is excreted in urine (as conjugated forms of buprenorphine and norbuprenorphine).
Toxicity Manifestations of acute overdose include pinpoint pupils, sedation, hypotension, respiratory depression and death.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Alvimopan Opioids like buprenorphine may enhance the adverse/toxic effect of Alvimopan. This is most notable for patients receiving long-term (i.e., more than 7 days) opiates prior to alvimopan initiation. Consider therapy modification.
Atazanavir Atazanavir may increase the serum concentration of Buprenorphine. Buprenorphine may decrease the serum concentration of Atazanavir. Avoid use of buprenorphine in patients receiving atazanavir without ritonavir boosting due to possible decreases in atazanavir exposure. In patients receiving buprenorphine with atazanavir/ritonavir, monitor for increased buprenorphine effects and consider dose reductions if patients experience adverse effects.
Conivaptan Conivaptan may increase the serum concentration of CYP3A4 Substrates like buprenorphine. Upon completion/discontinuation of conivaptan, allow at least 7 days before initiating therapy with drugs that are CYP3A4 substrates.
Droperidol Droperidol may enhance the CNS depressant effect of CNS Depressants like buprenorphine. Consider dose reductions of droperidol or of other CNS agents (e.g., opioids, barbiturates) with concomitant use.
Etravirine Buprenorphine, when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to monitor for a decrease in buprenorphine levels (ie. reduced analgesia, and signs of opioid withdrawal).
Isocarboxazid Buprenorphine may enhance the adverse/toxic effect of MAO Inhibitors like isocarboxazid. When possible, avoid use of buprenorphine in patients who have used a monoamine oxidase inhibitor within the past 14 days due to possible severe adverse effects.
Linezolid Buprenorphine may enhance the adverse/toxic effect of MAO Inhibitors like linezolid. When possible, avoid use of buprenorphine in patients who have used a monoamine oxidase inhibitor within the past 14 days due to possible severe adverse effects.
Moclobemide Buprenorphine may enhance the adverse/toxic effect of MAO Inhibitors like moclobemide. When possible, avoid use of buprenorphine in patients who have used a monoamine oxidase inhibitor within the past 14 days due to possible severe adverse effects.
Phenelzine Buprenorphine may enhance the adverse/toxic effect of MAO Inhibitors like phenelzine. When possible, avoid use of buprenorphine in patients who have used a monoamine oxidase inhibitor within the past 14 days due to possible severe adverse effects.
Procarbazine Buprenorphine may enhance the adverse/toxic effect of MAO Inhibitors like procarbazine. When possible, avoid use of buprenorphine in patients who have used a monoamine oxidase inhibitor within the past 14 days due to possible severe adverse effects.
Rasagiline Buprenorphine may enhance the adverse/toxic effect of MAO Inhibitors like rasagiline. When possible, avoid use of buprenorphine in patients who have used a monoamine oxidase inhibitor within the past 14 days due to possible severe adverse effects.
Selegiline Buprenorphine may enhance the adverse/toxic effect of MAO Inhibitors like selegiline. When possible, avoid use of buprenorphine in patients who have used a monoamine oxidase inhibitor within the past 14 days due to possible severe adverse effects.
Telithromycin Telithromycin may reduce clearance of Buprenorphine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Buprenorphine if Telithromycin is initiated, discontinued or dose changed.
Tranylcypromine Buprenorphine may enhance the adverse/toxic effect of MAO Inhibitors like tranylcypromine. When possible, avoid use of buprenorphine in patients who have used a monoamine oxidase inhibitor within the past 14 days due to possible severe adverse effects.
Triprolidine The CNS depressants, Triprolidine and Buprenorphine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of buprenorphine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of buprenorphine if voriconazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Mu-type opioid receptor
Name Mu-type opioid receptor
Gene Name OPRM1
Pharmacological action yes
Actions partial agonist
References
  • Kishioka S, Paronis CA, Lewis JW, Woods JH: Buprenorphine and methoclocinnamox: agonist and antagonist effects on respiratory function in rhesus monkeys. Eur J Pharmacol. 2000 Mar 17;391(3):289-97. - Pubmed
  • Zubieta J, Greenwald MK, Lombardi U, Woods JH, Kilbourn MR, Jewett DM, Koeppe RA, Schuster CR, Johanson CE: Buprenorphine-induced changes in mu-opioid receptor availability in male heroin-dependent volunteers: a preliminary study. Neuropsychopharmacology. 2000 Sep;23(3):326-34. - Pubmed
  • Sanchez-Blazquez P, Gomez-Serranillos P, Garzon J: Agonists determine the pattern of G-protein activation in mu-opioid receptor-mediated supraspinal analgesia. Brain Res Bull. 2001 Jan 15;54(2):229-35. - Pubmed
  • Mizoguchi H, Wu HE, Narita M, Hall FS, Sora I, Uhl GR, Nagase H, Tseng LF: Antagonistic property of buprenorphine for putative epsilon-opioid receptor-mediated G-protein activation by beta-endorphin in pons/medulla of the mu-opioid receptor knockout mouse. Neuroscience. 2002;115(3):715-21. - Pubmed
  • Ide S, Minami M, Satoh M, Uhl GR, Sora I, Ikeda K: Buprenorphine antinociception is abolished, but naloxone-sensitive reward is retained, in mu-opioid receptor knockout mice. Neuropsychopharmacology. 2004 Sep;29(9):1656-63. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.0309
Kappa-type opioid receptor
Name Kappa-type opioid receptor
Gene Name OPRK1
Pharmacological action yes
Actions antagonist
References
  • Boothby LA, Doering PL: Buprenorphine for the treatment of opioid dependence. Am J Health Syst Pharm. 2007 Feb 1;64(3):266-72. - Pubmed
  • Robinson SE: Buprenorphine-containing treatments: place in the management of opioid addiction. CNS Drugs. 2006;20(9):697-712. - Pubmed
DTHybrid score 0.8161
Delta-type opioid receptor
Name Delta-type opioid receptor
Gene Name OPRD1
Pharmacological action unknown
Actions antagonist
References
  • Induru RR, Davis MP: Buprenorphine for neuropathic pain--targeting hyperalgesia. Am J Hosp Palliat Care. 2009 Dec-2010 Jan;26(6):470-3. Epub 2009 Aug 7. - Pubmed
  • Lester PA, Traynor JR: Comparison of the in vitro efficacy of mu, delta, kappa and ORL1 receptor agonists and non-selective opioid agonists in dog brain membranes. Brain Res. 2006 Feb 16;1073-1074:290-6. Epub 2006 Jan 27. - Pubmed
  • Megarbane B, Marie N, Pirnay S, Borron SW, Gueye PN, Risede P, Monier C, Noble F, Baud FJ: Buprenorphine is protective against the depressive effects of norbuprenorphine on ventilation. Toxicol Appl Pharmacol. 2006 May 1;212(3):256-67. Epub 2005 Sep 16. - Pubmed
DTHybrid score 0.8442

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Kobayashi K, Yamamoto T, Chiba K, Tani M, Shimada N, Ishizaki T, Kuroiwa Y: Human buprenorphine N-dealkylation is catalyzed by cytochrome P450 3A4. Drug Metab Dispos. 1998 Aug;26(8):818-21. - Pubmed
DTHybrid score 1.1034
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5958
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.7723
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5728
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4882
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.2971
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7859
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2662
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6568
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6147
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3907

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Tournier N, Chevillard L, Megarbane B, Pirnay S, Scherrmann JM, Decleves X: Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15. Epub 2009 Nov 4. - Pubmed
DTHybrid score 0.6732
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Tournier N, Chevillard L, Megarbane B, Pirnay S, Scherrmann JM, Decleves X: Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15. Epub 2009 Nov 4. - Pubmed
DTHybrid score 0.3105

Predictions


Id Partner name Gene Name Score
6030 Cytochrome P450 2B6 CYP2B6 0.3387
6013 Cytochrome P450 2E1 CYP2E1 0.2576
6024 Cytochrome P450 1A1 CYP1A1 0.2222
20 Prostaglandin G/H synthase 1 PTGS1 0.1948
587 Serum albumin ALB 0.1894
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1385
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1358
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.1236
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1214
824 Sodium-dependent serotonin transporter SLC6A4 0.1196
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1185
1716 Tripartite motif-containing protein 13 TRIM13 0.115
862 Multidrug resistance-associated protein 1 ABCC1 0.1142
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1104
492 Histamine H1 receptor HRH1 0.1075
1729 Solute carrier family 22 member 6 SLC22A6 0.1
290 Prostaglandin G/H synthase 2 PTGS2 0.0963
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0946
6145 Solute carrier family 22 member 1 SLC22A1 0.0904
1898 Cytochrome P450 1B1 CYP1B1 0.088
1262 Corticotropin-lipotropin POMC 0.0867
3811 Cytochrome P450 19A1 CYP19A1 0.0854
502 5-hydroxytryptamine 2A receptor HTR2A 0.0785
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0772
831 D(2) dopamine receptor DRD2 0.0747
6144 Solute carrier family 22 member 2 SLC22A2 0.0725
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0707
776 Bile salt export pump ABCB11 0.0702
556 Alpha-1A adrenergic receptor ADRA1A 0.0694
320 5-hydroxytryptamine 1A receptor HTR1A 0.0652
341 5-hydroxytryptamine 3 receptor HTR3A 0.0624
118 Organic cation/carnitine transporter 2 SLC22A5 0.0607
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0597
590 5-hydroxytryptamine 2C receptor HTR2C 0.0593
2164 Multidrug resistance-associated protein 4 ABCC4 0.0592
766 Beta-2 adrenergic receptor ADRB2 0.059
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0589
136 Estrogen receptor ESR1 0.0587
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0585
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0581
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0574
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0565
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0557
6031 Cytochrome P450 3A43 CYP3A43 0.0556
318 Alpha-2A adrenergic receptor ADRA2A 0.0534
871 Glucocorticoid receptor NR3C1 0.052
6143 Solute carrier family 22 member 7 SLC22A7 0.0519
6142 Solute carrier family 22 member 8 SLC22A8 0.0519
468 Cytochrome P450 4A11 CYP4A11 0.0513
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0505
713 Sodium-dependent dopamine transporter SLC6A3 0.0495
23 D(1A) dopamine receptor DRD1 0.0495
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0493
731 HIV-1 protease HIV-1 protease 0.0472
817 DNA topoisomerase 2-alpha TOP2A 0.0469
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0469
465 Calmodulin CALM1 0.0464
193 Beta-1 adrenergic receptor ADRB1 0.0459
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0446
6147 Solute carrier family 22 member 3 SLC22A3 0.0445
3941 Amine oxidase [flavin-containing] A MAOA 0.0442
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0442
632 Alpha-1B adrenergic receptor ADRA1B 0.0436
319 Opioid receptor, sigma 1 OPRS1 0.043
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0427
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0418
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0417
174 Sigma 1-type opioid receptor SIGMAR1 0.041
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0409
844 Epidermal growth factor receptor EGFR 0.0408
260 Cytochrome P450 51 ERG11 0.0407
761 Cytochrome P450 51 ERG11 0.0407
3163 Cytochrome P450 51 cyp51 0.0407
274 Muscarinic acetylcholine receptor M5 CHRM5 0.04
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0399
885 5-hydroxytryptamine 1B receptor HTR1B 0.0393
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0392
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0391
450 Muscarinic acetylcholine receptor M4 CHRM4 0.039
4137 Nociceptin receptor OPRL1 0.0389
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0384
6102 Arylamine N-acetyltransferase 2 NAT2 0.0383
638 D(3) dopamine receptor DRD3 0.0381
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0376
4604 Liver carboxylesterase 1 CES1 0.0364
504 Mast/stem cell growth factor receptor KIT 0.0357
6148 Multidrug resistance-associated protein 7 ABCC10 0.0356
6182 Cytochrome P450 2J2 CYP2J2 0.0354
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.035
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0345
3810 Catechol O-methyltransferase COMT 0.0343
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0341
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.034
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0329
3923 Cholinesterase BCHE 0.0329
3939 Amine oxidase [flavin-containing] B MAOB 0.0324
833 Organic cation/carnitine transporter 1 SLC22A4 0.0322
789 Alpha-1D adrenergic receptor ADRA1D 0.0318
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0315
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0315
725 5-hydroxytryptamine 1D receptor HTR1D 0.0313
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.031
1024 Solute carrier family 22 member 11 SLC22A11 0.0307
6137 Multidrug resistance-associated protein 6 ABCC6 0.0296
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0292
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.029
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0286
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0286
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0285
4120 NADPH--cytochrome P450 reductase POR 0.0285
228 Beta platelet-derived growth factor receptor PDGFRB 0.0284
26 Vascular endothelial growth factor receptor 3 FLT4 0.0282
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0279
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0279
891 Dihydropteroate synthase folP 0.0275
5359 Dihydropteroate synthase folP 0.0275
7175 Dihydropteroate synthase sulI 0.0275
629 Alpha-2B adrenergic receptor ADRA2B 0.0274
380 Cytochrome P450 17A1 CYP17A1 0.0273
614 Progesterone receptor PGR 0.0273
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0272
407 Vascular endothelial growth factor receptor 2 KDR 0.0271
32 Vascular endothelial growth factor receptor 1 FLT1 0.027
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0267
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0261
36 Insulin receptor INSR 0.0258
477 DNA topoisomerase 4 subunit A parC 0.0256
886 DNA topoisomerase 4 subunit A parC 0.0256
6226 DNA topoisomerase 4 subunit A parC 0.0256
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0254
1757 Myeloperoxidase MPO 0.0254
738 Monocarboxylate transporter 1 SLC16A1 0.0254
404 DNA gyrase subunit A gyrA 0.0252
6224 DNA gyrase subunit A gyrA 0.0252
6141 Sodium/bile acid cotransporter SLC10A1 0.0248
1353 DNA topoisomerase 1 TOP1 0.0247
3552 DNA topoisomerase 1 topA 0.0247
122 P2Y purinoceptor 12 P2RY12 0.0246
378 Alpha-2C adrenergic receptor ADRA2C 0.0246
6014 Cytochrome P450 2A13 CYP2A13 0.0245
70 Type-1 angiotensin II receptor AGTR1 0.0238
146 Androgen receptor AR 0.0235
6136 Multidrug resistance-associated protein 5 ABCC5 0.0234
275 Arachidonate 5-lipoxygenase ALOX5 0.0232
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0231
432 D(4) dopamine receptor DRD4 0.023
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0229
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0229
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0229
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0229
811 Translocator protein TSPO 0.0229
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0228
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0227
737 Mineralocorticoid receptor NR3C2 0.0225
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0224
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0222
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0222
94 5-hydroxytryptamine 4 receptor HTR4 0.0222
756 Sex hormone-binding globulin SHBG 0.0221
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.022
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.022
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.022
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.022
869 Estrogen receptor beta ESR2 0.0219
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0217
6220 Aryl hydrocarbon receptor AHR 0.0214
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0213
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0211
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0211
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0208
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0208
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0206
436 5-hydroxytryptamine 2B receptor HTR2B 0.0203
29 Tubulin beta-1 chain TUBB1 0.0201
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0199
232 Corticosteroid-binding globulin SERPINA6 0.0198
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0197
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0196
1291 cAMP response element-binding protein CREB1 0.0195
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0194
3866 Serum amyloid A protein SAA1 0.019
1200 AMBP protein AMBP 0.019
1932 Apolipoprotein E APOE 0.019
777 Tumor necrosis factor TNF 0.019
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0189
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0189
124 Histamine H2 receptor HRH2 0.0188
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0187
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0186
716 5-hydroxytryptamine 7 receptor HTR7 0.0186
1192 Sulfotransferase 1A1 SULT1A1 0.0186
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0183
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.018
4210 Toll-like receptor 4 TLR4 0.0177
5838 Transient receptor potential cation channel subfamily V member 3 TRPV3 0.0176
2162 Transient receptor potential cation channel subfamily M member 8 TRPM8 0.0176
1944 Transient receptor potential cation channel subfamily A member 1 TRPA1 0.0176
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0175
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0175
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0175
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0174
161 Tubulin beta chain TUBB 0.0174
312 Tubulin beta chain TUB2 0.0174
373 Transthyretin TTR 0.0173
102 DNA topoisomerase I, mitochondrial TOP1MT 0.017
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.017
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0167
1010 Cytochrome P450 51A1 CYP51A1 0.0167
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0166
1618 High affinity nerve growth factor receptor NTRK1 0.0166
818 50S ribosomal protein L10 rplJ 0.0165
6174 50S ribosomal protein L32 rpmF 0.0165
165 FL cytokine receptor FLT3 0.0165
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0164
273 Apoptosis regulator Bcl-2 BCL2 0.0164
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0163
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0161
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0161
4237 50S ribosomal protein L22 rplV 0.016
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0159
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0157
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0157
2539 Tubulin alpha-1 chain TUBA4A 0.0156
85 Growth hormone receptor GHR 0.0156
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0156
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0155
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0153
4238 50S ribosomal protein L4 rplD 0.0153
5578 50S ribosomal protein L4 rplD 0.0153
6173 50S ribosomal protein L4 rplD 0.0153
6219 50S ribosomal protein L4 rplD 0.0153
474 Acetylcholinesterase ACHE 0.0153
3947 Xanthine dehydrogenase/oxidase XDH 0.0152
952 Dipeptidyl peptidase 4 DPP4 0.0151
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.015
427 Substance-P receptor TACR1 0.0149
723 Cytosolic phospholipase A2 PLA2G4A 0.0148
1656 CYP2B protein CYP2B 0.0143
163 D(1B) dopamine receptor DRD5 0.0142
33 Cystine/glutamate transporter SLC7A11 0.014
1178 Adenosine A2a receptor ADORA2A 0.0138
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0137
54 Prothrombin F2 0.0137
84 Nuclear receptor 0B1 NR0B1 0.0137
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0137
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0137
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0136
4773 Deoxycytidine kinase DCK 0.0136
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0136
1050 Bile salt sulfotransferase SULT2A1 0.0134
528 5-hydroxytryptamine 1E receptor HTR1E 0.0134
365 Dihydrofolate reductase DHFR 0.0134
2381 Dihydrofolate reductase DFR1 0.0134
2833 Dihydrofolate reductase Not Available 0.0134
2931 Dihydrofolate reductase folA 0.0134
3544 Dihydrofolate reductase folA 0.0134
3682 Dihydrofolate reductase folA 0.0134
6642 Dihydrofolate reductase folA 0.0134
6756 Dihydrofolate reductase dfrA 0.0134
117 Sterol O-acyltransferase 1 SOAT1 0.0134
16 Adenosine A1 receptor ADORA1 0.0134
823 Fibroblast growth factor receptor 2 FGFR2 0.0133
1256 5-hydroxytryptamine 6 receptor HTR6 0.0133
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0132
6020 Aldehyde oxidase AOX1 0.0131
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.013
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.013
6085 Fatty acid-binding protein, intestinal FABP2 0.0128
469 Annexin A1 ANXA1 0.0127
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
5787 Angiopoietin-1 receptor TEK 0.0126
68 Cannabinoid receptor 1 CNR1 0.0123
705 Glutamate receptor 1 GRIA1 0.0123
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0122
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0121
992 Protein tyrosine kinase 2 beta PTK2B 0.0121
921 Glutamate receptor 2 GRIA2 0.0121
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0121
511 5-hydroxytryptamine 1F receptor HTR1F 0.012
88 Retinoic acid receptor RXR-beta RXRB 0.012
1852 Microtubule-associated protein 2 MAP2 0.0119
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0118
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0118
239 Coagulation factor X F10 0.0118
3809 Estrogen-related receptor gamma ESRRG 0.0117
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0116
6432 Transporter snf 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
131 Synaptic vesicular amine transporter SLC18A2 0.0115
295 Carbonic anhydrase 1 CA1 0.0115
3808 Dihydropteroate synthase 2 folP2 0.0113
3601 Dihydropteroate synthase 1 folP1 0.0113
3807 Dihydropteroate synthase 1 folP1 0.0113
6103 Arylamine N-acetyltransferase 1 NAT1 0.0113
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0111
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
780 Retinoic acid receptor RXR-gamma RXRG 0.0108
24 Thymidylate synthase TMP1 0.0107
359 Thymidylate synthase TYMS 0.0107
2626 Thymidylate synthase thyA 0.0107
2729 Thymidylate synthase thyA 0.0107
5352 Thymidylate synthase THYA 0.0107
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0107
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0107
518 Peroxidase/catalase T katG 0.0106
4122 Histone deacetylase 2 HDAC2 0.0106
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0106
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0106
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0105
6599 HTH-type transcriptional regulator ttgR ttgR 0.0105
482 Glycine receptor subunit alpha-1 GLRA1 0.0105
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0105
904 Glutathione S-transferase P GSTP1 0.0104
4132 Chloride channel protein ClC-Ka CLCNKA 0.0104
1275 Estrogen sulfotransferase SULT1E1 0.0104
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0102
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0101
5923 Microtubule-associated protein tau MAPT 0.0101
5924 Microtubule-associated protein 4 MAP4 0.0101
768 FK506-binding protein 1A FKBP1A 0.01
3856 Fibroblast growth factor receptor 3 FGFR3 0.0099
106 Cannabinoid receptor 2 CNR2 0.0099
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0099
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0099
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0099
1039 Histone deacetylase 9 HDAC9 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
489 Monocarboxylate transporter 2 SLC16A7 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
183 Vascular endothelial growth factor A VEGFA 0.0097
4203 Histamine N-methyltransferase HNMT 0.0096
459 Retinoic acid receptor RXR-alpha RXRA 0.0096
5300 Antigen peptide transporter 1 TAP1 0.0096
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0096
49 Endothelin B receptor EDNRB 0.0096
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0095
936 Ephrin type-A receptor 2 EPHA2 0.0095
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0095
162 Retinoic acid receptor gamma-1 RARG 0.0093
3937 Fatty-acid amide hydrolase FAAH 0.0093
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0093
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0093
6146 High affinity copper uptake protein 1 SLC31A1 0.0092
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0092
3932 Glutathione S-transferase A2 GSTA2 0.0092
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0092
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0091
578 Endothelin-1 receptor EDNRA 0.009
814 Ryanodine receptor 1 RYR1 0.009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0089
770 Retinoic acid-induced protein 3 GPRC5A 0.0089
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0089
1517 Beta-3 adrenergic receptor ADRB3 0.0089
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0089
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
908 Glutathione S-transferase theta-1 GSTT1 0.0086
284 DNA-directed RNA polymerase beta chain rpoB 0.0086
5773 DNA-directed RNA polymerase beta chain rpoB 0.0086
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0086
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0085
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0085
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0084
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0084
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0083
6044 Serum paraoxonase/lactonase 3 PON3 0.0082
1629 Transcription factor AP-1 JUN 0.0082
565 Extracellular calcium-sensing receptor CASR 0.008
1196 Complement decay-accelerating factor CD55 0.008
3917 Methylenetetrahydrofolate reductase MTHFR 0.0079
3426 Glutamine synthetase glnA 0.0079
3987 Glutamine synthetase GLUL 0.0079
4311 tRNA TRDMT1 0.0079
4325 tRNA trmD 0.0079
4328 tRNA trmD 0.0079
173 Toll-like receptor 7 TLR7 0.0079
537 ATP synthase delta chain, mitochondrial ATP5D 0.0079
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
569 Retinal dehydrogenase 2 ALDH1A2 0.0078
563 Thyroid peroxidase TPO 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0076
244 Angiotensin-converting enzyme ACE 0.0076
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0076
2449 Tubulin alpha-3 chain TUBA1A 0.0076
2230 Catalase CAT 0.0076
3249 Catalase katA 0.0076
3625 Catalase katA 0.0076
4539 Catalase katA 0.0076
4941 Catalase katB 0.0076
6043 Putative G-protein coupled receptor 44 GPR44 0.0076
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
5798 Mitogen-activated protein kinase 11 MAPK11 0.0074
1541 Metalloproteinase mmp20 0.0074
976 Platelet glycoprotein IX GP9 0.0074
7 Nitric oxide synthase, inducible NOS2 0.0074
4192 DNA topoisomerase 2-beta TOP2B 0.0073
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0073
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0073
611 Retinal dehydrogenase 1 ALDH1A1 0.0073
2981 Phospholipase A2, membrane associated PLA2G2A 0.0072
357 Carbonic anhydrase 2 CA2 0.0072
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0072
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
4217 Telomerase reverse transcriptase TERT 0.007
267 Plasminogen activator inhibitor 1 SERPINE1 0.0069
2808 Chloramphenicol acetyltransferase 3 cat3 0.0069
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0069
251 Alcohol dehydrogenase 1A ADH1A 0.0069
3086 Plasmepsin-2 Not Available 0.0068
1483 Membrane copper amine oxidase AOC3 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
6138 Multidrug resistance protein 3 ABCB4 0.0067
153 Dopamine beta-hydroxylase DBH 0.0067
1630 Integrin beta-2 ITGB2 0.0066
4103 Proteasome subunit beta type 2 PSMB2 0.0066
4102 Proteasome subunit beta type 5 PSMB5 0.0066
4101 Proteasome subunit beta type 1 PSMB1 0.0066
6500 Phospholipase A2 PLA2G1B 0.0066
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0066
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
1650 Heme carrier protein 1 SLC46A1 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
444 Alcohol dehydrogenase 1B ADH1B 0.0065
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0064
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0064
6221 Steroid hormone receptor ERR1 ESRRA 0.0064
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0063
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0063
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0063
133 Dihydropterate synthase sulI 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
5934 Cytochrome P450 26A1 CYP26A1 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0061
856 Vitamin D3 receptor VDR 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
1864 RET proto-oncogene RET 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
4226 Uridine phosphorylase 2 UPP2 0.006
6126 Carbonic anhydrase 7 CA7 0.006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0059
1360 Sphingomyelin phosphodiesterase SMPD1 0.0059
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0059
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0059
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0059
634 Squalene monooxygenase SQLE 0.0059
7196 Squalene monooxygenase ERG1 0.0059
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0059
2021 Thrombomodulin THBD 0.0058
6824 Tyrosine-protein kinase Lyn LYN 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0058
5880 Thrombopoietin receptor MPL 0.0058
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0058
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
3639 Thymidine phosphorylase deoA 0.0056
3936 Thymidine phosphorylase TYMP 0.0056
2320 Thymidine kinase, cytosolic TK1 0.0055
517 Alcohol dehydrogenase 1C ADH1C 0.0055
4225 Uridine phosphorylase 1 UPP1 0.0055
6163 Copper-transporting ATPase 2 ATP7B 0.0055
6165 Copper-transporting ATPase 1 ATP7A 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
6149 Solute carrier family 22 member 10 SLC22A10 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0054
896 Glutathione S-transferase Mu 1 GSTM1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
2216 Fibroblast growth factor receptor 4 FGFR4 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
712 Tubulin alpha chain TUB1 0.0052
3913 Glutamic acid decarboxylase GAD65 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0051
413 Amidophosphoribosyltransferase PPAT 0.0051
2515 Amidophosphoribosyltransferase purF 0.0051
3714 Amidophosphoribosyltransferase purF 0.0051
461 Glycine receptor subunit alpha-3 GLRA3 0.0051
581 Cytochrome P450 2R1 CYP2R1 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
572 Integrin alpha-L ITGAL 0.005
6048 Troponin C, skeletal muscle TNNC2 0.005
164 Histamine H4 receptor HRH4 0.0049
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0049
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0049
3957 Adenosine deaminase ADA 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0046
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0046
6167 Organic solute transporter subunit beta OSTB 0.0045
6166 Organic solute transporter subunit alpha OSTA 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0045
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0045
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0045
1063 Signal transducer and activator of transcription 5B STAT5B 0.0045
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0045
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0044
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
2298 Cytochrome P450-cam camC 0.0043
3904 Alanine aminotransferase 2 GPT2 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0042
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0042
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0042
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0041
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0041
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0041
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0041
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0041
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1792 Tissue-type plasminogen activator PLAT 0.004
730 Retinoic acid receptor alpha RARA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.004
484 Tyrosine-protein kinase ABL2 ABL2 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1992 Vitamin D-binding protein GC 0.0038
6042 Prostaglandin reductase 2 PTGR2 0.0038
1760 Aminopeptidase N ANPEP 0.0038
6843 Aminopeptidase N pepN 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
291 Nitric-oxide synthase, endothelial NOS3 0.0037
760 Fibroblast growth factor 1 FGF1 0.0036
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
751 Potassium channel subfamily K member 6 KCNK6 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
6837 Serine/threonine-protein kinase 17B STK17B 0.0035
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
293 Gamma-glutamyl hydrolase GGH 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0033
5626 Nucleoside diphosphate kinase B NME2 0.0033
172 Potassium channel subfamily K member 1 KCNK1 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1374 Natriuretic peptides B NPPB 0.0031
1827 Gap junction alpha-1 protein GJA1 0.0031
1908 Vascular cell adhesion protein 1 VCAM1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.003
6228 Nuclear receptor coactivator 1 NCOA1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
2207 Rhodopsin RHO 0.003
702 UMP-CMP kinase CMPK1 0.003
6241 Nuclear receptor coactivator 2 NCOA2 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
1313 Lactoylglutathione lyase GLO1 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
400 Coagulation factor IX F9 0.0027
5461 Coagulation factor IX F9 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
5294 Nucleoside diphosphate kinase A NME1 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0026
1268 Neuropeptide S receptor NPSR1 0.0026
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
6859 Protein S100-A4 S100A4 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0025
604 Vitamin K-dependent protein Z PROZ 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
3830 Calreticulin CALR 0.0025
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0025
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6218 Pannexin-1 PANX1 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
6073 Potassium channel subfamily K member 9 KCNK9 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
6072 Potassium channel subfamily K member 3 KCNK3 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
1245 Vitamin K-dependent protein S PROS1 0.0023
422 Vitamin K-dependent protein C PROC 0.0023
1341 Histamine H3 receptor HRH3 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
820 Glycine receptor subunit alpha-2 GLRA2 0.0023
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
448 Vitamin K-dependent gamma-carboxylase GGCX 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
1058 Cell division protein kinase 5 CDK5 0.002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0019
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0019
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
6168 Solute carrier family 22 member 16 SLC22A16 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
798 Osteocalcin BGLAP 0.0019
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
76 Nitric-oxide synthase, brain NOS1 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
3587 Gastrotropin FABP6 0.0017
3221 Cytochrome c4 cc4 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
369 Coagulation factor VII F7 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
4948 Cytochrome c-553 Not Available 0.0017
4923 Cytochrome c3 DvMF_2499 0.0017
4945 Cytochrome c3 Not Available 0.0017
4949 Cytochrome c3 DVU_3171 0.0017
4968 Cytochrome c3 cytc3 0.0017
4997 Cytochrome c3 SO_2727 0.0017
5219 Cytochrome c3 cyd 0.0017
4902 Nine-heme cytochrome c Ddes_2038 0.0017
3189 High-molecular-weight cytochrome c hmcA 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6677 Myelin P2 protein PMP2 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
4954 Soluble cytochrome b558 Not Available 0.0014
4934 Cytochrome c-551 nirM 0.0014
5218 Cytochrome c-551 nirM 0.0014
4905 Cytochrome c2 Not Available 0.0014
4939 Cytochrome c2 cycA 0.0014
4964 Cytochrome c2 cycA 0.0014
4979 Cytochrome c2 cycA 0.0014
6673 Cytochrome c2 cycA 0.0014
4915 Cytochrome c-550 psbV 0.0014
4959 Cytochrome c-550 psbV 0.0014
5216 Cytochrome c-550 psbV 0.0014
4925 Cytochrome c-type protein SHP shp 0.0014
4947 Bacterial hemoglobin vhb 0.0014
4998 Hemoglobin-like protein yjbI yjbI 0.0014
4975 Cytochrome c-556 RPA3973 0.0014
4943 Cytochrome c6 petJ 0.0014
4916 Cyanoglobin glbN 0.0014
4984 Neuroglobin NGB 0.0014
4936 Cytochrome c2 iso-2 Not Available 0.0014
4994 Hemoglobin-like protein HbO glbO 0.0014
4907 Cytochrome c-L moxG 0.0014
6865 Cytochrome c-L moxG 0.0014
4909 CooA protein cooA 0.0014
644 Heme oxygenase 2 HMOX2 0.0014
4982 Heme oxygenase 2 pbsA2 0.0014
4942 Diheme cytochrome c napB napB 0.0014
4935 Cytochrome c-554 cycA1 0.0014
4904 Cytochrome c family protein GSU1996 0.0014
4910 Cytoglobin CYGB 0.0014
4961 Hemophore HasA hasA 0.0014
4971 Nonaheme cytochrome c hmcA 0.0014
4981 Iron-starvation protein PigA pigA 0.0014
5000 HemO hemO 0.0014
4989 Cytochrome c551 peroxidase ccp 0.0014
5222 Cytochrome c551 peroxidase ccpA 0.0014
4976 Apocytochrome f petA 0.0014
6407 Apocytochrome f petA 0.0014
4999 Cytochrome P450 165B3 CYP165B3 0.0014
4764 Cytochrome P450 165C4 CYP165C4 0.0014
4960 Putative cytochrome P450-family protein SCO7417 0.0014
4931 Cytochrome P450 167A1 CYP167A1 0.0014
4926 Heme-based aerotactic transducer hemAT hemAT 0.0014
4937 Cytochrome oxidase subunit II rcoxA 0.0014
4993 Hydroxylamine oxidoreductase hao1 0.0014
4903 Methyl-accepting chemotaxis protein Tar4 0.0014
4922 Cytochrome c, putative SO_4144 0.0014
4972 P450cin cinA 0.0014
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0014
3093 Catalase HPII katE 0.0014
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0014
4952 Catalase/peroxidase katA 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
4386 Hemoglobin-like protein HbN glbN 0.0014
5818 Folate receptor alpha FOLR1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1507 Cytochrome c CYCS 0.0011
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0011
4920 Peroxidase/catalase katG 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
2119 Cytochrome b5 CYB5A 0.0011
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.001
4990 PpcA ppcA 0.001
4988 Sulfite oxidase, mitochondrial SUOX 0.001
3375 Acidic cytochrome c3 Not Available 0.001
4385 Cytochrome c' Not Available 0.001
4967 Cytochrome c' cycA 0.001
5038 Cytochrome c' Not Available 0.001
5223 Cytochrome c' cycP 0.001
2915 Sensor protein fixL fixL 0.001
4944 Sensor protein fixL fixL 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
3570 Cytochrome P450 152A1 cypC 0.001
4992 Cytochrome c peroxidase Not Available 0.001
4813 Heme oxygenase hmuO 0.001
5769 Heme oxygenase Not Available 0.001
4289 Cytochrome P450 TT_P0059 0.001
6262 Cytochrome P450 staP 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
3670 Soluble cytochrome b562 precursor cybC 0.0009
3411 Cytochrome P450 121 cyp121 0.0009
3291 Cytochrome c-552 cycA 0.0009
4927 Cytochrome c-552 nrfA 0.0009
4938 Cytochrome c-552 cycA 0.0009
4953 Cytochrome c-552 nrfA 0.0009
5217 Cytochrome c-552 cycM 0.0009
2617 Nitric oxide synthase oxygenase nos 0.0009
2701 Nitric oxide synthase oxygenase nos 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
3102 Flavohemoprotein hmp 0.0009
4969 Flavohemoprotein hmp 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2972 6-deoxyerythronolide B hydroxylase eryF 0.0008
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
4608 Putative cytochrome P450 SCO1207 0.0008
4963 Putative cytochrome P450 SCO2884 0.0008
6254 Putative cytochrome P450 SCO6998 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
358 Cystathionine beta-synthase CBS 0.0007
822 Aldose reductase AKR1B1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
693 Hemoglobin subunit beta HBB 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
6268 Hydroxyacid oxidase 1 HAO1 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
↑