DT-Web

DB00163 - Vitamin E


Identification
Name Vitamin E
Accession Number DB00163 (EXPT03227, NUTR00061)
Type small molecule
Description A generic descriptor for all tocopherols and tocotrienols that exhibit alpha-tocopherol activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of isoprenoids. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 430.7061
Groups approved
Monoisotopic Weight 430.381080844
Pharmacology
Indication Vitamin E, known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. It may be of limited benefit in some with asthma and rheumatoid arthritis. It may be helpful in some neurological diseases including Alzheimer's, some eye disorders including cataracts, and diabetes and premenstrual syndrome. It may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported. It may help relieve some muscle cramps.
Mechanism of action Although all forms of Vitamin E exhibit antioxidant activity, it is known that the antioxidant activity of vitamin E is not sufficient to explain the vitamin's biological activity.
Vitamin E's anti-atherogenic activity involves the inhibition of the oxidation of LDL and the accumulation of oxLDL in the arterial wall. It also appears to reduce oxLDL-induced apoptosis in human endothelial cells. Oxidation of LDL is a key early step in atherogenesis as it triggers a number of events which lead to the formation of atherosclerotic plaque. In addition, vitamin E inhibits protein kinase C (PKC) activity. PKC plays a role in smooth muscle cell proliferation, and, thus, the inhibition of PKC results in inhibition of smooth muscle cell proliferation, which is involved in atherogenesis.
Vitamin E's antithrombotic and anticoagulant activities involves the downregulation of the expression of intracellular cell adhesion molecule(ICAM)-1 and vascular cell adhesion molecule(VCAM)-1 which lowers the adhesion of blood components to the endothelium. In addition, vitamin E upregulates the expression of cytosolic phospholipase A2 and cyclooxygenase (COX)-1 which in turn enhances the release of prostacyclin. Prostacyclin is a vasodilating factor and inhibitor of platelet aggregation and platelet release. It is also known that platelet aggregation is mediated by a mechanism involving the binding of fibrinogen to the glycoprotein IIb/IIIa (GPIIb/IIIa) complex of platelets. GPIIb/IIIa is the major membrane receptor protein that is key to the role of the platelet aggregation response. GPIIb is the alpha-subunit of this platelet membrane protein. Alpha-tocopherol downregulates GPIIb promoter activity which results in reduction of GPIIb protein expression and decreased platelet aggregation. Vitamin E has also been found in culture to decrease plasma production of thrombin, a protein which binds to platelets and induces aggregation. A metabolite of vitamin E called vitamin E quinone or alpha-tocopheryl quinone (TQ) is a potent anticoagulant. This metabolite inhibits vitamin K-dependent carboxylase, which is a major enzyme in the coagulation cascade.
The neuroprotective effects of vitamin E are explained by its antioxidant effects. Many disorders of the nervous system are caused by oxidative stress. Vitamin E protects against this stress, thereby protecting the nervouse system.
The immunomodulatory effects of Vitamin E have been demonstrated in vitro, where alpha-tocopherol increases mitogenic response of T lymphocytes from aged mice. The mechanism of this response by vitamin E is not well understood, however it has been suggested that vitamin E itself may have mitogenic activity independent of its antioxidant activity.
Lastly, the mechanism of action of vitamin E's antiviral effects (primarily against HIV-1) involves its antioxidant activity. Vitamin E reduces oxidative stress, which is thought to contribute to HIV-1 pathogenesis, as well as to the pathogenesis of other viral infections. Vitamin E also affects membrane integrity and fluidity and, since HIV-1 is a membraned virus, altering membrane fluidity of HIV-1 may interfere with its ability to bind to cell-receptor sites, thus decreasing its infectivity.
Absorption 50 to 80% absorbed from gastrointestinal tract.
Protein binding Bound to beta-lipoproteins in blood.
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amprenavir Increased serum levels of vitamin E
Orlistat Orlistat may impair the absorption of vitamin E, a fat soluble vitamin. Oral vitamin E should be administered 2 hours prior to or post orlistat administration.
Food Interactions Not Available

Targets


Nuclear receptor subfamily 1 group I member 2
Name Nuclear receptor subfamily 1 group I member 2
Gene Name NR1I2
Pharmacological action unknown
Actions Not Available
References
  • Rabovsky A, Cuomo J, Eich N: Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects. Clin Chim Acta. 2006 Sep;371(1-2):55-60. Epub 2006 Mar 6. - Pubmed
  • Meijerman I, Beijnen JH, Schellens JH: Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist. 2006 Jul-Aug;11(7):742-52. - Pubmed
DTHybrid score 0.6443
Protein kinase C beta type
Name Protein kinase C beta type
Gene Name PRKCB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Wigg SJ, Tare M, Forbes J, Cooper ME, Thomas MC, Coleman HA, Parkington HC, O'Brien RC: Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-beta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats. Diabetologia. 2004 Jun;47(6):1038-46. Epub 2004 Jun 8. - Pubmed
  • Huang Y, Ishizuka T, Miura A, Kajita K, Ishizawa M, Kimura M, Yamamoto Y, Kawai Y, Morita H, Uno Y, Yasuda K: Effect of 1 alpha,25-dihydroxy vitamin D3 and vitamin E on insulin-induced glucose uptake in rat adipocytes. Diabetes Res Clin Pract. 2002 Mar;55(3):175-83. - Pubmed
  • Ganz MB, Seftel A: Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E. Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E146-52. - Pubmed
DTHybrid score 1.1112
Arachidonate 5-lipoxygenase
Name Arachidonate 5-lipoxygenase
Gene Name ALOX5
Pharmacological action unknown
Actions Not Available
References
  • Taccone-Gallucci M, Manca-di-Villahermosa S, Battistini L, Stuffler RG, Tedesco M, Maccarrone M: N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity. Kidney Int. 2006 Apr;69(8):1450-4. - Pubmed
DTHybrid score 0.5914
Protein kinase C alpha type
Name Protein kinase C alpha type
Gene Name PRKCA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Azzi A, Boscoboinik D, Clement S, Marilley D, Ozer NK, Ricciarelli R, Tasinato A: Alpha-tocopherol as a modulator of smooth muscle cell proliferation. Prostaglandins Leukot Essent Fatty Acids. 1997 Oct;57(4-5):507-14. - Pubmed
  • Sylvester PW, McIntyre BS, Gapor A, Briski KP: Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation. Cell Prolif. 2001 Dec;34(6):347-57. - Pubmed
  • Huang Y, Ishizuka T, Miura A, Kajita K, Ishizawa M, Kimura M, Yamamoto Y, Kawai Y, Morita H, Uno Y, Yasuda K: Effect of 1 alpha,25-dihydroxy vitamin D3 and vitamin E on insulin-induced glucose uptake in rat adipocytes. Diabetes Res Clin Pract. 2002 Mar;55(3):175-83. - Pubmed
DTHybrid score 0.7254
Diacylglycerol kinase alpha
Name Diacylglycerol kinase alpha
Gene Name DGKA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7115
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Name Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Gene Name PPP2CB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.718
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Gene Name PPP2CA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8114
SEC14-like protein 4
Name SEC14-like protein 4
Gene Name SEC14L4
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7191
SEC14-like protein 3
Name SEC14-like protein 3
Gene Name SEC14L3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Ye X, Ji C, Yin G, Tang R, Zeng L, Gu S, Ying K, Xie Y, Zhao RC, Mao Y: Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. Mol Biol Rep. 2004 Mar;31(1):59-63. - Pubmed
DTHybrid score 0.7206
SEC14-like protein 2
Name SEC14-like protein 2
Gene Name SEC14L2
Pharmacological action unknown
Actions Not Available
References
  • Neuzil J, Dong LF, Wang XF, Zingg JM: Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells. Biochem Biophys Res Commun. 2006 May 19;343(4):1113-7. Epub 2006 Mar 31. - Pubmed
  • Ni J, Pang ST, Yeh S: Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells. Prostate. 2007 Apr 1;67(5):463-71. - Pubmed
DTHybrid score 0.6224

Enzymes


Glutathione S-transferase A2
Name Glutathione S-transferase A2
Gene Name GSTA2
Actions inducer
References
  • Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31. Epub 2010 Feb 12. - Pubmed
DTHybrid score 0.5575
Glutathione S-transferase P
Name Glutathione S-transferase P
Gene Name GSTP1
Actions inhibitor
References
  • Ralat LA, Colman RF: Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi. Biochemistry. 2006 Oct 17;45(41):12491-9. - Pubmed
DTHybrid score 0.937
Glutathione transferase omega-1
Name Glutathione transferase omega-1
Gene Name GSTO1
Actions inhibitor
References
  • Sampayo-Reyes A, Zakharyan RA: Tocopherol esters inhibit human glutathione S-transferase omega. Acta Biochim Pol. 2006;53(3):547-52. Epub 2006 Oct 1. - Pubmed
DTHybrid score 0.5752
Glutathione S-transferase Mu 3
Name Glutathione S-transferase Mu 3
Gene Name GSTM3
Actions inducer
References
  • Mustacich DJ, Gohil K, Bruno RS, Yan M, Leonard SW, Ho E, Cross CE, Traber MG: Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice. J Nutr Biochem. 2009 Jun;20(6):469-76. Epub 2008 Sep 11. - Pubmed
DTHybrid score 0.5752
Glutamate--cysteine ligase catalytic subunit
Name Glutamate--cysteine ligase catalytic subunit
Gene Name GCLC
Actions inducer
References
  • Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31. Epub 2010 Feb 12. - Pubmed
DTHybrid score 0.505
NAD(P)H dehydrogenase [quinone] 1
Name NAD(P)H dehydrogenase [quinone] 1
Gene Name NQO1
Actions inducer
References
  • Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31. Epub 2010 Feb 12. - Pubmed
DTHybrid score 1.114
Heme oxygenase 1
Name Heme oxygenase 1
Gene Name HMOX1
Actions inducer
References
  • Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31. Epub 2010 Feb 12. - Pubmed
DTHybrid score 1.3706
Superoxide dismutase [Cu-Zn]
Name Superoxide dismutase [Cu-Zn]
Gene Name SOD1
Actions inducer
References
  • Feng Z, Liu Z, Li X, Jia H, Sun L, Tian C, Jia L, Liu J: alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. J Nutr Biochem. 2010 Dec;21(12):1222-31. Epub 2010 Feb 12. - Pubmed
DTHybrid score 0.5194

Carriers


Predictions


Id Partner name Gene Name Score
3391 Heme oxygenase 1 pbsA1 1.3706
6250 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform PPP2R5C 0.2883
6251 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform PPP2R1A 0.2882
2421 Signal peptidase I lepB 0.2105
4184 Protein kinase C delta type PRKCD 0.2031
896 Glutathione S-transferase Mu 1 GSTM1 0.1768
2981 Phospholipase A2, membrane associated PLA2G2A 0.1581
4031 Glutathione S-transferase A1 GSTA1 0.144
6312 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit PPP1CA 0.1261
6313 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform PPP2R2A 0.1256
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1014
20 Prostaglandin G/H synthase 1 PTGS1 0.0993
908 Glutathione S-transferase theta-1 GSTT1 0.0958
4512 Cytochrome P450 3A4 CYP3A4 0.085
4041 Microsomal glutathione S-transferase 2 MGST2 0.083
654 Flavin reductase BLVRB 0.0798
1757 Myeloperoxidase MPO 0.0796
6163 Copper-transporting ATPase 2 ATP7B 0.0756
6165 Copper-transporting ATPase 1 ATP7A 0.0755
6146 High affinity copper uptake protein 1 SLC31A1 0.0702
901 Glutathione S-transferase Mu 4 GSTM4 0.0694
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0654
290 Prostaglandin G/H synthase 2 PTGS2 0.0645
3947 Xanthine dehydrogenase/oxidase XDH 0.0617
6024 Cytochrome P450 1A1 CYP1A1 0.0611
1588 Multidrug resistance protein 1 ABCB1 0.0605
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0559
5433 UPF0230 protein TM_1468 TM_1468 0.0533
3616 Fatty acid-binding protein, epidermal FABP5 0.0533
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0533
5431 Lipid binding protein Not Available 0.0532
6677 Myelin P2 protein PMP2 0.0529
4924 Cytochrome P450 2C8 CYP2C8 0.0527
207 Glutathione synthetase GSS 0.0524
5269 Glutathione synthetase gshB 0.0524
284 DNA-directed RNA polymerase beta chain rpoB 0.0495
5773 DNA-directed RNA polymerase beta chain rpoB 0.0495
6459 Glycodelin PAEP 0.0477
6013 Cytochrome P450 2E1 CYP2E1 0.0474
6182 Cytochrome P450 2J2 CYP2J2 0.0472
1729 Solute carrier family 22 member 6 SLC22A6 0.0471
587 Serum albumin ALB 0.0461
5241 Probable thiol peroxidase tpx 0.0454
5239 Exopolyphosphatase ppx 0.0453
4407 FMN-dependent NADH-azoreductase azoR 0.045
5169 FMN-dependent NADH-azoreductase azoR 0.045
4440 NADH peroxidase npr 0.044
4035 Glutathione S-transferase Mu 5 GSTM5 0.044
2211 Fatty acid-binding protein, heart FABP3 0.0437
903 Glutathione S-transferase A5 GSTA5 0.0436
4042 Glutathione transferase omega-2 GSTO2 0.0434
900 Glutathione S-transferase A4 GSTA4 0.0428
4034 Glutaredoxin-1 GLRX 0.0427
4040 Glutathione peroxidase 7 GPX7 0.0426
4032 Microsomal glutathione S-transferase 1 MGST1 0.0426
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0426
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0426
1928 Leukotriene C4 synthase LTC4S 0.0426
911 Glutathione peroxidase 3 GPX3 0.0426
4037 Hypothetical protein GPX1 0.0426
4297 Hypothetical protein SP_1951 0.0426
4521 Hypothetical protein BC_2969 0.0426
4540 Hypothetical protein TM_1070 0.0426
4555 Hypothetical protein MT1739 0.0426
4569 Hypothetical protein mshD 0.0426
4578 Hypothetical protein PA3270 0.0426
4747 Hypothetical protein PA3967 0.0426
5177 Hypothetical protein TM_0096 0.0426
5194 Hypothetical protein PA1204 0.0426
5240 Hypothetical protein Rv2991 0.0426
5370 Hypothetical protein TM_1158 0.0426
5710 Hypothetical protein Tb927.5.1360 0.0426
4029 Microsomal glutathione S-transferase 3 MGST3 0.0426
4036 Glutathione peroxidase 6 GPX6 0.0426
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0426
910 Epididymal secretory glutathione peroxidase GPX5 0.0426
4033 S-formylglutathione hydrolase ESD 0.0426
906 Glutathione peroxidase 1 GPX1 0.0426
907 Glutathione peroxidase 2 GPX2 0.0426
4038 Glutathione peroxidase 4 GPX4 0.0426
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0426
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0426
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0426
1313 Lactoylglutathione lyase GLO1 0.0415
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0409
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0402
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0398
743 Phosphatidylserine decarboxylase proenzyme PISD 0.0396
1848 Phosphatidylserine synthase 1 PTDSS1 0.0396
4051 Phosphatidylserine synthase 2 PTDSS2 0.0396
211 Scavenger receptor class B member 1 SCARB1 0.0395
4053 Sphingomyelin phosphodiesterase 3 SMPD3 0.0395
4047 Diacylglycerol kinase gamma DGKG 0.0395
4052 Sphingomyelin phosphodiesterase 4 SMPD4 0.0395
1477 Probable phospholipid-transporting ATPase IA ATP8A1 0.0395
4048 Diacylglycerol kinase delta DGKD 0.0395
2750 Aspartate 1-decarboxylase panD 0.0394
4200 Cytochrome P450 1A2 CYP1A2 0.0391
4757 Cytochrome P450 2C9 CYP2C9 0.0391
171 Cysteine dioxygenase CDO-1 0.0377
1314 Thiamine transporter 2 SLC19A3 0.0376
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0376
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0376
2408 Tyrosine-protein kinase SYK SYK 0.0374
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0372
898 Glutathione S-transferase A3 GSTA3 0.037
897 Glutathione S-transferase kappa 1 GSTK1 0.0369
6131 Carbonic anhydrase 14 CA14 0.0369
6085 Fatty acid-binding protein, intestinal FABP2 0.0367
468 Cytochrome P450 4A11 CYP4A11 0.0361
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.036
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.036
6136 Multidrug resistance-associated protein 5 ABCC5 0.0358
3319 Hydroxyacylglutathione hydrolase HAGH 0.0357
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0353
6122 Carbonic anhydrase 3 CA3 0.0351
909 Maleylacetoacetate isomerase GSTZ1 0.0337
6030 Cytochrome P450 2B6 CYP2B6 0.0333
634 Squalene monooxygenase SQLE 0.0328
7196 Squalene monooxygenase ERG1 0.0328
3759 Glutathione S-transferase gst 0.0325
4541 Glutathione S-transferase GST 0.0325
2183 Fatty acid-binding protein, adipocyte FABP4 0.032
2165 Glutathione S-transferase Mu 2 GSTM2 0.0316
3923 Cholinesterase BCHE 0.0314
2207 Rhodopsin RHO 0.0313
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0311
3873 Prolyl endopeptidase PREP 0.031
6928 Prolyl endopeptidase Not Available 0.031
3007 Carbonic anhydrase 12 CA12 0.0307
4205 Carbonic anhydrase 9 CA9 0.0307
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
1024 Solute carrier family 22 member 11 SLC22A11 0.0301
2159 Quinone oxidoreductase CRYZ 0.0297
626 Cysteine dioxygenase type 1 CDO1 0.0296
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0295
703 NADPH azoreductase azr 0.0295
89 Cysteine sulfinic acid decarboxylase CSAD 0.0289
6126 Carbonic anhydrase 7 CA7 0.0289
1898 Cytochrome P450 1B1 CYP1B1 0.0288
862 Multidrug resistance-associated protein 1 ABCC1 0.0285
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0284
2236 Casein kinase II subunit alpha CSNK2A1 0.0284
358 Cystathionine beta-synthase CBS 0.0282
558 Solute carrier family 12 member 1 SLC12A1 0.0278
169 Cysteine desulfurase, mitochondrial NFS1 0.0276
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0275
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.027
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0269
4118 Cytochrome P450 3A5 CYP3A5 0.0266
1405 Thiopurine S-methyltransferase TPMT 0.0265
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0252
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0252
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0252
6144 Solute carrier family 22 member 2 SLC22A2 0.0246
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0245
5718 Cytochrome P450 2A6 CYP2A6 0.0244
714 Glutathione reductase, mitochondrial GSR 0.0242
2907 Oxysterols receptor LXR-beta NR1H2 0.0242
6283 Oxysterols receptor LXR-alpha NR1H3 0.0242
2112 Toll-like receptor 9 TLR9 0.0237
868 Cystathionine gamma-lyase CTH 0.0231
592 Carbonic anhydrase 4 CA4 0.0226
357 Carbonic anhydrase 2 CA2 0.0222
295 Carbonic anhydrase 1 CA1 0.022
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.021
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0203
6151 Monocarboxylate transporter 10 SLC16A10 0.0203
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0198
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0196
6137 Multidrug resistance-associated protein 6 ABCC6 0.0196
776 Bile salt export pump ABCB11 0.0193
777 Tumor necrosis factor TNF 0.0191
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0191
2164 Multidrug resistance-associated protein 4 ABCC4 0.0188
88 Retinoic acid receptor RXR-beta RXRB 0.0176
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0174
6228 Nuclear receptor coactivator 1 NCOA1 0.0173
6241 Nuclear receptor coactivator 2 NCOA2 0.0171
6147 Solute carrier family 22 member 3 SLC22A3 0.0171
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0167
4119 Cytochrome P450 2D6 CYP2D6 0.0156
5898 Complement C3 C3 0.0154
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0146
6145 Solute carrier family 22 member 1 SLC22A1 0.0144
6016 Cytochrome P450 2C19 CYP2C19 0.0144
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0139
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0133
6148 Multidrug resistance-associated protein 7 ABCC10 0.0133
33 Cystine/glutamate transporter SLC7A11 0.0129
136 Estrogen receptor ESR1 0.0126
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0124
6141 Sodium/bile acid cotransporter SLC10A1 0.0122
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.012
2517 Subtilisin BPN' apr 0.0116
2596 Acetyl-CoA acetyltransferase phbA 0.0105
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0104
1507 Cytochrome c CYCS 0.0101
1654 Interleukin-1 beta IL1B 0.01
2443 Azurin azu 0.0097
1650 Heme carrier protein 1 SLC46A1 0.0096
6142 Solute carrier family 22 member 8 SLC22A8 0.0088
844 Epidermal growth factor receptor EGFR 0.0086
76 Nitric-oxide synthase, brain NOS1 0.0083
494 Caspase-1 CASP1 0.0083
183 Vascular endothelial growth factor A VEGFA 0.008
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.008
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.008
4026 Aspartyl aminopeptidase DNPEP 0.008
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.008
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.008
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.008
1912 Excitatory amino acid transporter 1 SLC1A3 0.008
4016 Excitatory amino acid transporter 5 SLC1A7 0.008
4019 Excitatory amino acid transporter 4 SLC1A6 0.008
1047 Excitatory amino acid transporter 2 SLC1A2 0.008
664 Glutamate decarboxylase 2 GAD2 0.008
3890 Glutamate decarboxylase 2 GAD2 0.008
4020 Glutamyl aminopeptidase ENPEP 0.008
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.008
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.008
4017 5-oxoprolinase OPLAH 0.008
922 Glutamate receptor 4 GRIA4 0.008
927 Metabotropic glutamate receptor 8 GRM8 0.008
925 Metabotropic glutamate receptor 4 GRM4 0.008
926 Metabotropic glutamate receptor 7 GRM7 0.008
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.008
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.008
4018 Glutamate receptor delta-2 subunit GRID2 0.008
4027 Glutamate receptor delta-1 subunit GRID1 0.008
6143 Solute carrier family 22 member 7 SLC22A7 0.0079
22 30S ribosomal protein S4 rpsD 0.0076
6714 30S ribosomal protein S4 rpsD 0.0076
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0075
6107 Cytochrome P450 3A7 CYP3A7 0.0074
140 30S ribosomal protein S9 rpsI 0.0072
6719 30S ribosomal protein S9 rpsI 0.0072
6725 30S ribosomal protein S9 rpsI 0.0072
3221 Cytochrome c4 cc4 0.0071
5923 Microtubule-associated protein tau MAPT 0.0071
5924 Microtubule-associated protein 4 MAP4 0.007
2077 Caspase-3 CASP3 0.0069
65 Matrix metalloproteinase-9 Not Available 0.0068
400 Coagulation factor IX F9 0.0068
5461 Coagulation factor IX F9 0.0068
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0066
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0066
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0066
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0066
5 Glutaminase liver isoform, mitochondrial GLS2 0.0066
917 Glutaminase kidney isoform, mitochondrial GLS 0.0066
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0066
5261 Phosphoribosylformylglycinamidine synthase purL 0.0066
1852 Microtubule-associated protein 2 MAP2 0.0066
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0064
604 Vitamin K-dependent protein Z PROZ 0.0064
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0064
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0064
273 Apoptosis regulator Bcl-2 BCL2 0.0061
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0061
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0061
665 Phosphoserine aminotransferase PSAT1 0.0061
4652 Phosphoserine aminotransferase serC 0.0061
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0061
420 Glutamate decarboxylase 1 GAD1 0.0061
3900 Glutamate decarboxylase 1 GAD1 0.0061
6432 Transporter snf 0.0061
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0061
1671 Excitatory amino acid transporter 3 SLC1A1 0.0059
625 Glutamate carboxypeptidase 2 FOLH1 0.0059
29 Tubulin beta-1 chain TUBB1 0.0059
3877 Growth-inhibiting protein 18 GIG18 0.0057
1245 Vitamin K-dependent protein S PROS1 0.0057
422 Vitamin K-dependent protein C PROC 0.0057
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0056
916 Metabotropic glutamate receptor 1 GRM1 0.0056
3709 Glycerol uptake facilitator protein glpF 0.0055
3116 Bacterioferritin bfr 0.0055
4906 Bacterioferritin bfr 0.0055
4965 Bacterioferritin bfr 0.0055
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0055
3173 Enolase eno 0.0055
3393 TGF-beta receptor type-2 TGFBR2 0.0055
3238 Multidrug resistance protein mexA mexA 0.0055
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0055
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0053
763 Tyrosine aminotransferase TAT 0.0053
5493 Tyrosine aminotransferase Not Available 0.0053
923 Glutamate receptor 3 GRIA3 0.0053
735 Alanine aminotransferase 1 GPT 0.0053
3904 Alanine aminotransferase 2 GPT2 0.0053
426 Aspartate aminotransferase, mitochondrial GOT2 0.0052
798 Osteocalcin BGLAP 0.0052
4608 Putative cytochrome P450 SCO1207 0.0052
4963 Putative cytochrome P450 SCO2884 0.0052
6254 Putative cytochrome P450 SCO6998 0.0052
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0052
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0052
817 DNA topoisomerase 2-alpha TOP2A 0.0051
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0051
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0051
4527 Putative hydrolase ycdX ycdX 0.0051
4546 Aminotransferase, putative TM_1131 0.0051
4545 Molybdopterin-converting factor subunit 2 moaE 0.0051
4524 Mannose-6-phosphate isomerase yvyI 0.0051
4547 Iron binding protein FbpA fbpA 0.0051
4514 Citrate lyase beta subunit-like protein citE 0.0051
4781 Citrate lyase beta subunit-like protein DR_1240 0.0051
4106 Guanylate kinase GUK1 0.0051
4516 Guanylate kinase gmk 0.0051
4538 Hypothetical protein VC1899 VC_1899 0.0051
4529 Oxalate decarboxylase oxdC oxdC 0.0051
4536 Transcriptional regulator, IclR family TM_0065 0.0051
2501 Protein ygbM ygbM 0.0051
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0051
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0051
4522 Arginine N-succinyltransferase subunit alpha astA 0.0051
4548 Gyrase B gyrB 0.0051
658 Para-aminobenzoate synthase component 1 pabB 0.0051
4515 Peripheral plasma membrane protein CASK CASK 0.0051
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.005
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0049
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0049
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0049
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0049
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0048
2852 DNA mismatch repair protein mutL mutL 0.0048
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0048
369 Coagulation factor VII F7 0.0048
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0048
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0047
4496 C-terminal-binding protein 1 CTBP1 0.0046
705 Glutamate receptor 1 GRIA1 0.0046
3102 Flavohemoprotein hmp 0.0046
4969 Flavohemoprotein hmp 0.0046
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0045
3426 Glutamine synthetase glnA 0.0045
3987 Glutamine synthetase GLUL 0.0045
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0045
3261 Signal recognition particle protein ffh 0.0045
4517 Probable butyrate kinase 2 buk2 0.0045
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0044
3191 Histidinol dehydrogenase hisD 0.0044
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0044
4542 Glutaminase 1 glsA1 0.0044
4544 Glutaminase 1 glsA1 0.0044
3237 Beta-lactamase OXA-2 bla 0.0044
4528 Phenazine biosynthesis protein PhzD phzD1 0.0044
56 Delta-aminolevulinic acid dehydratase ALAD 0.0044
2356 Delta-aminolevulinic acid dehydratase hemB 0.0044
3613 Delta-aminolevulinic acid dehydratase hemB 0.0044
3674 Delta-aminolevulinic acid dehydratase hemB 0.0044
2929 (S)-2-haloacid dehalogenase dhlB 0.0044
2995 (S)-2-haloacid dehalogenase Not Available 0.0044
4533 Glyoxalase family protein BC_1747 0.0044
4532 Gephyrin GPHN 0.0044
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0044
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0044
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0043
6020 Aldehyde oxidase AOX1 0.0043
444 Alcohol dehydrogenase 1B ADH1B 0.0043
7 Nitric oxide synthase, inducible NOS2 0.0043
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0042
291 Nitric-oxide synthase, endothelial NOS3 0.0042
436 5-hydroxytryptamine 2B receptor HTR2B 0.0042
4943 Cytochrome c6 petJ 0.0041
4947 Bacterial hemoglobin vhb 0.0041
4934 Cytochrome c-551 nirM 0.0041
5218 Cytochrome c-551 nirM 0.0041
4905 Cytochrome c2 Not Available 0.0041
4939 Cytochrome c2 cycA 0.0041
4964 Cytochrome c2 cycA 0.0041
4979 Cytochrome c2 cycA 0.0041
6673 Cytochrome c2 cycA 0.0041
4954 Soluble cytochrome b558 Not Available 0.0041
4910 Cytoglobin CYGB 0.0041
4916 Cyanoglobin glbN 0.0041
4984 Neuroglobin NGB 0.0041
4925 Cytochrome c-type protein SHP shp 0.0041
4994 Hemoglobin-like protein HbO glbO 0.0041
4907 Cytochrome c-L moxG 0.0041
6865 Cytochrome c-L moxG 0.0041
4981 Iron-starvation protein PigA pigA 0.0041
4975 Cytochrome c-556 RPA3973 0.0041
4936 Cytochrome c2 iso-2 Not Available 0.0041
4942 Diheme cytochrome c napB napB 0.0041
4961 Hemophore HasA hasA 0.0041
4915 Cytochrome c-550 psbV 0.0041
4959 Cytochrome c-550 psbV 0.0041
5216 Cytochrome c-550 psbV 0.0041
4998 Hemoglobin-like protein yjbI yjbI 0.0041
4935 Cytochrome c-554 cycA1 0.0041
4764 Cytochrome P450 165C4 CYP165C4 0.0041
4909 CooA protein cooA 0.0041
4989 Cytochrome c551 peroxidase ccp 0.0041
5222 Cytochrome c551 peroxidase ccpA 0.0041
4972 P450cin cinA 0.0041
4971 Nonaheme cytochrome c hmcA 0.0041
5000 HemO hemO 0.0041
4976 Apocytochrome f petA 0.0041
6407 Apocytochrome f petA 0.0041
4904 Cytochrome c family protein GSU1996 0.0041
4903 Methyl-accepting chemotaxis protein Tar4 0.0041
4960 Putative cytochrome P450-family protein SCO7417 0.0041
4931 Cytochrome P450 167A1 CYP167A1 0.0041
4926 Heme-based aerotactic transducer hemAT hemAT 0.0041
4937 Cytochrome oxidase subunit II rcoxA 0.0041
4922 Cytochrome c, putative SO_4144 0.0041
4999 Cytochrome P450 165B3 CYP165B3 0.0041
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0041
4993 Hydroxylamine oxidoreductase hao1 0.0041
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0041
4952 Catalase/peroxidase katA 0.0041
3093 Catalase HPII katE 0.0041
740 Argininosuccinate synthase ASS1 0.0041
865 Argininosuccinate synthase ASS1 0.0041
2680 Argininosuccinate synthase argG 0.0041
3194 Argininosuccinate synthase argG 0.0041
4192 DNA topoisomerase 2-beta TOP2B 0.0041
4531 Putative ketoacyl reductase actIII 0.0041
2775 Dihydroorotate dehydrogenase pyrD 0.0041
4311 tRNA TRDMT1 0.0041
4325 tRNA trmD 0.0041
4328 tRNA trmD 0.0041
3467 Methylglyoxal synthase mgsA 0.0041
597 Dihydropteridine reductase QDPR 0.0041
3583 6-phosphogluconolactonase pgl 0.0041
4692 A/G-specific adenine glycosylase mutY 0.004
605 Fumarate reductase flavoprotein subunit frdA 0.004
2709 Fumarate reductase flavoprotein subunit SO_0970 0.004
3673 Fumarate reductase flavoprotein subunit fccA 0.004
4912 Fumarate reductase flavoprotein subunit ifcA 0.004
6549 Fumarate reductase flavoprotein subunit frdA 0.004
6106 Cytochrome P450 2C18 CYP2C18 0.004
3811 Cytochrome P450 19A1 CYP19A1 0.004
4120 NADPH--cytochrome P450 reductase POR 0.0039
2802 Endoglucanase G celCCG 0.0039
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0038
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0038
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0038
6316 ADP-ribosylation factor 1 ARF1 0.0038
590 5-hydroxytryptamine 2C receptor HTR2C 0.0037
6168 Solute carrier family 22 member 16 SLC22A16 0.0037
6031 Cytochrome P450 3A43 CYP3A43 0.0037
3917 Methylenetetrahydrofolate reductase MTHFR 0.0037
824 Sodium-dependent serotonin transporter SLC6A4 0.0037
2688 Peptide deformylase def 0.0037
2708 Peptide deformylase def 0.0037
3004 Peptide deformylase def 0.0037
4337 Peptide deformylase def 0.0037
4338 Peptide deformylase def 0.0037
5368 Peptide deformylase def 0.0037
5371 Peptide deformylase def 0.0037
6375 Peptide deformylase def 0.0037
6378 Peptide deformylase def 0.0037
6379 Peptide deformylase def 0.0037
6776 Peptide deformylase def 0.0037
6900 Peptide deformylase def 0.0037
4534 Cytohesin-2 CYTH2 0.0037
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0037
239 Coagulation factor X F10 0.0037
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0036
2548 Subtilisin Carlsberg apr 0.0035
5448 Ribonuclease Z rnz 0.0035
5449 Hypothetical gliding protein mglB 0.0035
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0035
4705 Manganese catalase Not Available 0.0035
5439 33 kDa chaperonin hslO 0.0035
332 Beta-lactamase blaZ 0.0035
2478 Beta-lactamase ampC 0.0035
2613 Beta-lactamase ampC 0.0035
2635 Beta-lactamase ampC 0.0035
2700 Beta-lactamase penP 0.0035
5445 Beta-lactamase blaB 0.0035
6019 Beta-lactamase SHV-7 0.0035
6701 Beta-lactamase cphA 0.0035
5443 UPF0189 protein ymdB ymdB 0.0035
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0035
5440 UPF0067 protein yebR yebR 0.0035
2720 Copper-containing nitrite reductase nirK 0.0035
5454 Internalin-A inlA 0.0035
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0035
738 Monocarboxylate transporter 1 SLC16A1 0.0035
756 Sex hormone-binding globulin SHBG 0.0035
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0034
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0034
4498 Ornithine cyclodeaminase PP3533 0.0034
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0034
502 5-hydroxytryptamine 2A receptor HTR2A 0.0033
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0033
4920 Peroxidase/catalase katG 0.0033
4990 PpcA ppcA 0.0033
4813 Heme oxygenase hmuO 0.0033
5769 Heme oxygenase Not Available 0.0033
4948 Cytochrome c-553 Not Available 0.0033
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0033
2119 Cytochrome b5 CYB5A 0.0033
4923 Cytochrome c3 DvMF_2499 0.0033
4945 Cytochrome c3 Not Available 0.0033
4949 Cytochrome c3 DVU_3171 0.0033
4968 Cytochrome c3 cytc3 0.0033
4997 Cytochrome c3 SO_2727 0.0033
5219 Cytochrome c3 cyd 0.0033
4902 Nine-heme cytochrome c Ddes_2038 0.0033
3570 Cytochrome P450 152A1 cypC 0.0033
3189 High-molecular-weight cytochrome c hmcA 0.0033
4988 Sulfite oxidase, mitochondrial SUOX 0.0033
4289 Cytochrome P450 TT_P0059 0.0033
6262 Cytochrome P450 staP 0.0033
4992 Cytochrome c peroxidase Not Available 0.0033
4385 Cytochrome c' Not Available 0.0033
4967 Cytochrome c' cycA 0.0033
5038 Cytochrome c' Not Available 0.0033
5223 Cytochrome c' cycP 0.0033
2915 Sensor protein fixL fixL 0.0033
4944 Sensor protein fixL fixL 0.0033
3375 Acidic cytochrome c3 Not Available 0.0033
869 Estrogen receptor beta ESR2 0.0032
5450 Prolyl endopeptidase Pep pep 0.0031
4771 Dissimilatory copper-containing nitrite reductase nir 0.0031
3356 Diaminopimelate decarboxylase lysA 0.0031
2714 Chorismate mutase aroH 0.0031
4611 Chorismate mutase aroG 0.0031
3274 Hydroxylamine reductase hcp 0.0031
4804 Hydroxylamine reductase hcp 0.0031
54 Prothrombin F2 0.0031
760 Fibroblast growth factor 1 FGF1 0.0031
921 Glutamate receptor 2 GRIA2 0.0031
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.003
2230 Catalase CAT 0.003
3249 Catalase katA 0.003
3625 Catalase katA 0.003
4539 Catalase katA 0.003
4941 Catalase katB 0.003
3027 Streptavidin Not Available 0.003
3670 Soluble cytochrome b562 precursor cybC 0.0029
3411 Cytochrome P450 121 cyp121 0.0029
2617 Nitric oxide synthase oxygenase nos 0.0029
2701 Nitric oxide synthase oxygenase nos 0.0029
3291 Cytochrome c-552 cycA 0.0029
4927 Cytochrome c-552 nrfA 0.0029
4938 Cytochrome c-552 cycA 0.0029
4953 Cytochrome c-552 nrfA 0.0029
5217 Cytochrome c-552 cycM 0.0029
4386 Hemoglobin-like protein HbN glbN 0.0029
500 Monocarboxylate transporter 4 SLC16A3 0.0029
3399 Limonene-1,2-epoxide hydrolase limA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0028
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0028
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0028
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0028
5180 L(+)-mandelate dehydrogenase mdlB 0.0027
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0027
3127 Nitrite reductase nirS 0.0027
3284 Nitrite reductase nirS 0.0027
3500 Putative family 31 glucosidase yicI yicI 0.0027
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0027
3480 Mannan endo-1,4-beta-mannosidase manA 0.0027
577 Argininosuccinate lyase ASL 0.0026
1615 Chymase CMA1 0.0026
5682 Ribonuclease pancreatic RNASE1 0.0026
2972 6-deoxyerythronolide B hydroxylase eryF 0.0026
518 Peroxidase/catalase T katG 0.0026
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0025
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0025
373 Transthyretin TTR 0.0024
260 Cytochrome P450 51 ERG11 0.0024
761 Cytochrome P450 51 ERG11 0.0024
3163 Cytochrome P450 51 cyp51 0.0024
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0024
693 Hemoglobin subunit beta HBB 0.0023
6268 Hydroxyacid oxidase 1 HAO1 0.0022
5122 Mersacidin decarboxylase mrsD 0.0019
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0019
5095 Putidaredoxin reductase camA 0.0019
3763 5,10-methylenetetrahydrofolate reductase metF 0.0019
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0019
5094 5,10-methylenetetrahydrofolate reductase metF 0.0019
526 Thioredoxin reductase trxB 0.0019
3767 Thioredoxin reductase trxB 0.0019
5078 Amine oxidase, flavin-containing PSPTO1126 0.0019
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0019
5109 Outer membrane protein p64k or PM-6 m-6 0.0019
5115 FkbI fkbI 0.0019
5083 Cryptochrome DASH cry 0.0019
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0019
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0019
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0019
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0019
5081 L-aspartate oxidase nadB 0.0019
1410 Oxidoreductase HSD17B6 0.0019
4725 Oxidoreductase Not Available 0.0019
5124 Oxidoreductase Not Available 0.0019
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0019
3133 UDP-galactopyranose mutase glf 0.0019
5099 UDP-galactopyranose mutase glf 0.0019
5111 Phenylacetone monooxygenase pamO 0.0019
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0019
2298 Cytochrome P450-cam camC 0.0019
4486 Phenol 2-hydroxylase component B pheA2 0.0018
4477 Dihydrolipoyl dehydrogenase lpdV 0.0018
5077 Dihydrolipoyl dehydrogenase Not Available 0.0018
5117 Dihydrolipoyl dehydrogenase lpd 0.0018
4439 Ferredoxin reductase bphA4 0.0018
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0017
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0017
2268 Cholesterol oxidase choB 0.0017
2822 Cholesterol oxidase choA 0.0017
5072 N,N-dimethylglycine oxidase dmg 0.0017
5073 Ferredoxin--NADP reductase petH 0.0017
5076 Ferredoxin--NADP reductase fpr 0.0017
5119 Ferredoxin--NADP reductase petH 0.0017
5121 Ferredoxin--NADP reductase fpr 0.0017
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0017
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0017
3594 Deoxyribodipyrimidine photo-lyase phr 0.0017
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0017
5080 Deoxyribodipyrimidine photo-lyase phr 0.0017
2526 NADPH-ferredoxin reductase fprA fprA 0.0017
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0017
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0017
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0017
2470 Pyruvate oxidase pox5 0.0017
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0017
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0017
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0015
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0015
2893 Glycine oxidase thiO 0.0015
327 Glutathione reductase gor 0.0015
5110 Glutathione reductase GR2 0.0015
126 D-lactate dehydrogenase dld 0.0015
3545 D-lactate dehydrogenase Not Available 0.0015
4510 D-lactate dehydrogenase ldhA 0.0015
474 Acetylcholinesterase ACHE 0.0015
2567 Thymidylate synthase thyX thyX 0.0015
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0015
2823 Trypanothione reductase TPR 0.0015
2769 P-hydroxybenzoate hydroxylase pobA 0.0014
2809 P-hydroxybenzoate hydroxylase pobA 0.0014
816 Biliverdin reductase A BLVRA 0.0013
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0013
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0013
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0013
2380 Monomeric sarcosine oxidase soxA 0.0013
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0013
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0013
666 NADP-dependent malic enzyme ME1 0.0013
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0013
646 Malate dehydrogenase, cytoplasmic MDH1 0.0013
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0013
644 Heme oxygenase 2 HMOX2 0.0013
4982 Heme oxygenase 2 pbsA2 0.0013
6645 D-amino-acid oxidase DAO 0.0013
857 Malate dehydrogenase, mitochondrial MDH2 0.0013
396 Alcohol dehydrogenase 4 ADH4 0.0013
328 Sorbitol dehydrogenase SORD 0.0013
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0013
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0013
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0013
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0013
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0013
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0013
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0013
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0013
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0013
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0013
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0013
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0013
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0013
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0013
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0013
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0013
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0013
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0013
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0013
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0013
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0013
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0013
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0013
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0013
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0013
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0013
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0013
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0013
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0013
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0013
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0013
206 3-keto-steroid reductase HSD17B7 0.0013
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0013
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0013
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0013
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0013
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0013
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0013
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0013
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0013
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0013
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0013
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0013
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0013
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0013
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0013
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0013
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0013
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0013
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0013
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0013
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0013
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0013
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0013
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0013
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0013
34 7-dehydrocholesterol reductase DHCR7 0.0013
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0013
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0013
711 UDP-glucose 6-dehydrogenase UGDH 0.0013
3672 UDP-glucose 6-dehydrogenase hasB 0.0013
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0013
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0013
107 C-4 methylsterol oxidase SC4MOL 0.0013
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0013
3726 D-3-phosphoglycerate dehydrogenase serA 0.0013
4291 D-3-phosphoglycerate dehydrogenase serA 0.0013
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0013
729 GDP-L-fucose synthetase TSTA3 0.0013
3463 GDP-L-fucose synthetase fcl 0.0013
167 L-lactate dehydrogenase C chain LDHC 0.0013
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0013
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0013
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0013
643 Peroxisomal bifunctional enzyme EHHADH 0.0013
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0013
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0013
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0013
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0013
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0012
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0012
12 Alcohol dehydrogenase class 3 ADH5 0.0012
77 L-lactate dehydrogenase B chain LDHB 0.0012
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0012
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0012
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0012
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0012
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0012
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0011
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0011
13 Aminomethyltransferase, mitochondrial AMT 0.0011
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0011
6026 Alcohol dehydrogenase 6 ADH6 0.0011
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0011
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0011
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0011
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
611 Retinal dehydrogenase 1 ALDH1A1 0.001
569 Retinal dehydrogenase 2 ALDH1A2 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.001
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.001
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
279 Tyrosinase TYR 0.0009
380 Cytochrome P450 17A1 CYP17A1 0.0009
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0009
517 Alcohol dehydrogenase 1C ADH1C 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
822 Aldose reductase AKR1B1 0.0008
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0008
3939 Amine oxidase [flavin-containing] B MAOB 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
365 Dihydrofolate reductase DHFR 0.0008
2381 Dihydrofolate reductase DFR1 0.0008
2833 Dihydrofolate reductase Not Available 0.0008
2931 Dihydrofolate reductase folA 0.0008
3544 Dihydrofolate reductase folA 0.0008
3682 Dihydrofolate reductase folA 0.0008
6642 Dihydrofolate reductase folA 0.0008
6756 Dihydrofolate reductase dfrA 0.0008
3941 Amine oxidase [flavin-containing] A MAOA 0.0008
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