DT-Web: DB04938

Identification

Name

Ospemifene

Accession Number

DB04938

Type

small molecule

Description

Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Estrogen receptor agonist/antagonist

Molecular Weight

378.891

Groups

approved

Monoisotopic Weight

378.138657687

Pharmacology

Indication

Ospemifene is used for the treatment of moderate to dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause.

Mechanism of action

Ospemifene is a next generation SERM (selective estrogen receptor modulator) that selectively binds to estrogen receptors and either stimulates or blocks estrogen's activity in different tissue types. It has an agonistic effect on the endometrium.

Absorption

When a single oral dose of ospemifene 60 mg is given to postmenopausal women under fasted conditions, the pharmacokinetic parameters are as follows: Tmax = 2 hours (range of 1 - 8 hours); Cmax = 533 ng/mL; AUC (0-inf) = 4165 ngohr/mL. When the same aforementioned dose is given to postmenopausal women under fed conditions, the pharmacokinetic parameters are as follows: Tmax = 2.5 hours (1 - 6 hours); Cmax = 1198 ng/mL; AUC (0-inf) = 7521 ngohr/mL. Accumulation occurs following repeated doses. Time to steady state = 9 days. Although the bioavailability of ospemifene has not been formally evaluated, it is expected to have a low bioavailability because of its lipophilic nature.

Protein binding

>99% bound to serum proteins

Biotransformation

Ospemifene is hepatically metabolized via CYP3A4, CYP2C9, CYP2C19, and CYP2B6. The major metabolite was 4-hydroxyospemifene, 25% of the parent compound will undergo this biotransformation. Other metabolites include 4'-hydroxy-ospemifene, <7% of the parent compound will undergo this biotransformation. In order of decreasing potency, ospemifene was suggested to be a weak inhibitor for CYP2B6, CYP2C9, CYP2C19, CYP2C8, CYP2D6 and CYP3A4.

Route of elimination

Following an oral administration of ospemifene, approximately 75% and 7% of the dose was excreted in feces and urine, respectively. Less than 0.2% of the ospemifene dose was excreted unchanged in urine.

Toxicity

Adverse reactions (>=1 percent) include: hot flush, vaginal discharge, muscle spasms, genital discharge, hyperhidrosis.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Estradiol valerate/Dienogest	Pharmacodynamic synergist; contraindicated.
Fluconazole	Fluconazole, a moderate CYP3A / strong CYP2C9 / moderate CYP2C19 inhibitor, should not be used with ospemifene. Fluconazole increases the systemic exposure of ospemifene by 2.7-fold. Administration of fluconazole with ospemifene may increase the risk of adverse events.
Ketoconazole	Ketoconazole, a strong CYP3A4 inhibitor increases the systemic exposure of ospemifene by 1.4-fold. Administration of ketoconazole chronically with ospemifene may increase the risk of OSPHENA-related adverse reactions.
Omeprazole	Moderate CYP2C19 inhibitors may increase levels of ospemifene. Monitor concomitant therapy closely.
Rifampin	Rifampin, a strong CYP3A4 / moderate CYP2C9 / moderate CYP2C19 inducer, decreases the systemic exposure of ospemifene by 58%. Therefore, co-administration of ospemifene with drugs such as rifampin which induce CYP3A4, CYP2C9 and/or CYP2C19 activity would be expected to decrease the systemic exposure of ospemifene, which may decrease the clinical effect.

Food Interactions

In general, food increased the bioavailability of ospemifene by approximately 2-3 fold.

Estrogen receptor
Name	Estrogen receptor
Gene Name	ESR1
Pharmacological action	yes
Actions	antagonist,agonist
References	Komi J, Heikkinen J, Rutanen EM, Halonen K, Lammintausta R, Ylikorkala O: Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women. Gynecol Endocrinol. 2004 Mar;18(3):152-8. - Pubmed Wurz GT, Read KC, Marchisano-Karpman C, Gregg JP, Beckett LA, Yu Q, Degregorio MW: Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar mice. J Steroid Biochem Mol Biol. 2005 Nov;97(3):230-40. Epub 2005 Sep 8. - Pubmed
DTHybrid score	0.7084

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	FDA label - Tolonen A, Koskimies P, Turpeinen M, Uusitalo J, Lammintausta R, Pelkonen O: Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations. Drug Metabol Drug Interact. 2013 May 14:1-9. doi: 10.1515/dmdi-2013-0016. - Pubmed
DTHybrid score	0.4862
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	FDA label - Tolonen A, Koskimies P, Turpeinen M, Uusitalo J, Lammintausta R, Pelkonen O: Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations. Drug Metabol Drug Interact. 2013 May 14:1-9. doi: 10.1515/dmdi-2013-0016. - Pubmed
DTHybrid score	0.3811
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	FDA label - Tolonen A, Koskimies P, Turpeinen M, Uusitalo J, Lammintausta R, Pelkonen O: Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations. Drug Metabol Drug Interact. 2013 May 14:1-9. doi: 10.1515/dmdi-2013-0016. - Pubmed
DTHybrid score	0.3281
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Tolonen A, Koskimies P, Turpeinen M, Uusitalo J, Lammintausta R, Pelkonen O: Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations. Drug Metabol Drug Interact. 2013 May 14:1-9. doi: 10.1515/dmdi-2013-0016. - Pubmed
DTHybrid score	0.2663

Id	Partner name	Gene Name	Score
6241	Nuclear receptor coactivator 2	NCOA2	0.2306
4119	Cytochrome P450 2D6	CYP2D6	0.2073
4924	Cytochrome P450 2C8	CYP2C8	0.1864
4200	Cytochrome P450 1A2	CYP1A2	0.1835
1588	Multidrug resistance protein 1	ABCB1	0.1618
4118	Cytochrome P450 3A5	CYP3A5	0.1358
6013	Cytochrome P450 2E1	CYP2E1	0.1129
6107	Cytochrome P450 3A7	CYP3A7	0.0953
869	Estrogen receptor beta	ESR2	0.0874
5718	Cytochrome P450 2A6	CYP2A6	0.0816
614	Progesterone receptor	PGR	0.072
6024	Cytochrome P450 1A1	CYP1A1	0.0708
587	Serum albumin	ALB	0.0693
20	Prostaglandin G/H synthase 1	PTGS1	0.0672
3811	Cytochrome P450 19A1	CYP19A1	0.0599
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0558
6106	Cytochrome P450 2C18	CYP2C18	0.0475
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0439
492	Histamine H1 receptor	HRH1	0.0417
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0387
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0386
824	Sodium-dependent serotonin transporter	SLC6A4	0.0366
290	Prostaglandin G/H synthase 2	PTGS2	0.0328
862	Multidrug resistance-associated protein 1	ABCC1	0.0318
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0314
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0304
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0291
1729	Solute carrier family 22 member 6	SLC22A6	0.0283
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0278
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0273
731	HIV-1 protease	HIV-1 protease	0.0261
1898	Cytochrome P450 1B1	CYP1B1	0.026
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0258
146	Androgen receptor	AR	0.0257
6145	Solute carrier family 22 member 1	SLC22A1	0.0256
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0243
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0243
260	Cytochrome P450 51	ERG11	0.0242
761	Cytochrome P450 51	ERG11	0.0242
3163	Cytochrome P450 51	cyp51	0.0242
776	Bile salt export pump	ABCB11	0.0229
6144	Solute carrier family 22 member 2	SLC22A2	0.0228
556	Alpha-1A adrenergic receptor	ADRA1A	0.0227
713	Sodium-dependent dopamine transporter	SLC6A3	0.0226
871	Glucocorticoid receptor	NR3C1	0.0223
756	Sex hormone-binding globulin	SHBG	0.0223
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0219
122	P2Y purinoceptor 12	P2RY12	0.0208
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0208
6142	Solute carrier family 22 member 8	SLC22A8	0.0208
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0207
831	D(2) dopamine receptor	DRD2	0.0206
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0206
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0197
847	Mu-type opioid receptor	OPRM1	0.0197
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0194
468	Cytochrome P450 4A11	CYP4A11	0.0192
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0192
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0176
318	Alpha-2A adrenergic receptor	ADRA2A	0.0176
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0173
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0173
467	Delta-type opioid receptor	OPRD1	0.0171
2164	Multidrug resistance-associated protein 4	ABCC4	0.0171
617	Muscarinic acetylcholine receptor M2	CHRM2	0.017
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0166
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0166
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0165
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0164
696	Kappa-type opioid receptor	OPRK1	0.0162
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0161
891	Dihydropteroate synthase	folP	0.0157
5359	Dihydropteroate synthase	folP	0.0157
7175	Dihydropteroate synthase	sulI	0.0157
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0154
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0154
465	Calmodulin	CALM1	0.0153
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0153
3941	Amine oxidase [flavin-containing] A	MAOA	0.0151
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.015
632	Alpha-1B adrenergic receptor	ADRA1B	0.015
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0143
766	Beta-2 adrenergic receptor	ADRB2	0.0143
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0143
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0142
118	Organic cation/carnitine transporter 2	SLC22A5	0.014
6143	Solute carrier family 22 member 7	SLC22A7	0.0137
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0136
23	D(1A) dopamine receptor	DRD1	0.0135
6031	Cytochrome P450 3A43	CYP3A43	0.0131
6147	Solute carrier family 22 member 3	SLC22A3	0.0129
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0128
3939	Amine oxidase [flavin-containing] B	MAOB	0.0127
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0125
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0125
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0123
6228	Nuclear receptor coactivator 1	NCOA1	0.0122
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.012
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.012
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.012
687	Tyrosine-protein phosphatase non-receptor type 1	PTPN1	0.0118
3923	Cholinesterase	BCHE	0.0118
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0117
817	DNA topoisomerase 2-alpha	TOP2A	0.0116
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0113
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0112
6141	Sodium/bile acid cotransporter	SLC10A1	0.0111
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0111
70	Type-1 angiotensin II receptor	AGTR1	0.0111
789	Alpha-1D adrenergic receptor	ADRA1D	0.0109
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0109
1024	Solute carrier family 22 member 11	SLC22A11	0.0108
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0108
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0108
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0107
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0104
818	50S ribosomal protein L10	rplJ	0.0104
6182	Cytochrome P450 2J2	CYP2J2	0.0103
4120	NADPH--cytochrome P450 reductase	POR	0.0102
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0101
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0101
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0101
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0098
4604	Liver carboxylesterase 1	CES1	0.0097
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0097
811	Translocator protein	TSPO	0.0097
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0097
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0097
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0097
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0097
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0096
49	Endothelin B receptor	EDNRB	0.0096
6220	Aryl hydrocarbon receptor	AHR	0.0094
381	Prolactin receptor	PRLR	0.0093
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0093
482	Glycine receptor subunit alpha-1	GLRA1	0.0093
373	Transthyretin	TTR	0.0091
6137	Multidrug resistance-associated protein 6	ABCC6	0.0091
571	Melatonin receptor type 1A	MTNR1A	0.0091
362	Melatonin receptor type 1B	MTNR1B	0.0091
6136	Multidrug resistance-associated protein 5	ABCC5	0.0091
6020	Aldehyde oxidase	AOX1	0.0091
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0091
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.009
578	Endothelin-1 receptor	EDNRA	0.009
592	Carbonic anhydrase 4	CA4	0.009
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.009
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.009
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0089
833	Organic cation/carnitine transporter 1	SLC22A4	0.0089
1656	CYP2B protein	CYP2B	0.0089
174	Sigma 1-type opioid receptor	SIGMAR1	0.0087
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0087
193	Beta-1 adrenergic receptor	ADRB1	0.0087
2107	Microtubule-associated protein 1A	MAP1A	0.0087
3810	Catechol O-methyltransferase	COMT	0.0086
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0086
638	D(3) dopamine receptor	DRD3	0.0086
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0086
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0086
124	Histamine H2 receptor	HRH2	0.0084
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0084
1757	Myeloperoxidase	MPO	0.0084
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0083
504	Mast/stem cell growth factor receptor	KIT	0.0082
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0082
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0081
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0081
232	Corticosteroid-binding globulin	SERPINA6	0.008
295	Carbonic anhydrase 1	CA1	0.008
427	Substance-P receptor	TACR1	0.0079
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
1852	Microtubule-associated protein 2	MAP2	0.0077
161	Tubulin beta chain	TUBB	0.0076
312	Tubulin beta chain	TUB2	0.0076
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0076
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0075
407	Vascular endothelial growth factor receptor 2	KDR	0.0075
629	Alpha-2B adrenergic receptor	ADRA2B	0.0074
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0074
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0073
6148	Multidrug resistance-associated protein 7	ABCC10	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
1010	Cytochrome P450 51A1	CYP51A1	0.0072
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.007
705	Glutamate receptor 1	GRIA1	0.007
844	Epidermal growth factor receptor	EGFR	0.007
921	Glutamate receptor 2	GRIA2	0.0069
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0069
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0069
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0069
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0069
6014	Cytochrome P450 2A13	CYP2A13	0.0068
380	Cytochrome P450 17A1	CYP17A1	0.0068
777	Tumor necrosis factor	TNF	0.0068
357	Carbonic anhydrase 2	CA2	0.0067
716	5-hydroxytryptamine 7 receptor	HTR7	0.0067
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0067
29	Tubulin beta-1 chain	TUBB1	0.0066
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0066
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0066
6085	Fatty acid-binding protein, intestinal	FABP2	0.0065
26	Vascular endothelial growth factor receptor 3	FLT4	0.0063
133	Dihydropterate synthase	sulI	0.0063
6102	Arylamine N-acetyltransferase 2	NAT2	0.0062
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0062
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0062
32	Vascular endothelial growth factor receptor 1	FLT1	0.0061
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0059
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0059
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0059
68	Cannabinoid receptor 1	CNR1	0.0058
856	Vitamin D3 receptor	VDR	0.0058
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0058
432	D(4) dopamine receptor	DRD4	0.0058
378	Alpha-2C adrenergic receptor	ADRA2C	0.0058
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0057
183	Vascular endothelial growth factor A	VEGFA	0.0056
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0055
3809	Estrogen-related receptor gamma	ESRRG	0.0055
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0054
1649	Small inducible cytokine A2	CCL2	0.0054
365	Dihydrofolate reductase	DHFR	0.0053
2381	Dihydrofolate reductase	DFR1	0.0053
2833	Dihydrofolate reductase	Not Available	0.0053
2931	Dihydrofolate reductase	folA	0.0053
3544	Dihydrofolate reductase	folA	0.0053
3682	Dihydrofolate reductase	folA	0.0053
6642	Dihydrofolate reductase	folA	0.0053
6756	Dihydrofolate reductase	dfrA	0.0053
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0052
6126	Carbonic anhydrase 7	CA7	0.0052
94	5-hydroxytryptamine 4 receptor	HTR4	0.0051
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0051
952	Dipeptidyl peptidase 4	DPP4	0.0051
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
992	Protein tyrosine kinase 2 beta	PTK2B	0.005
275	Arachidonate 5-lipoxygenase	ALOX5	0.005
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0048
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0048
563	Thyroid peroxidase	TPO	0.0047
581	Cytochrome P450 2R1	CYP2R1	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0047
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0047
737	Mineralocorticoid receptor	NR3C2	0.0046
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
1618	High affinity nerve growth factor receptor	NTRK1	0.0045
474	Acetylcholinesterase	ACHE	0.0045
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0045
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0045
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0044
6138	Multidrug resistance protein 3	ABCB4	0.0044
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0044
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
284	DNA-directed RNA polymerase beta chain	rpoB	0.0043
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0043
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0043
2539	Tubulin alpha-1 chain	TUBA4A	0.0043
3830	Calreticulin	CALR	0.0042
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0042
3947	Xanthine dehydrogenase/oxidase	XDH	0.0042
4210	Toll-like receptor 4	TLR4	0.0041
780	Retinoic acid receptor RXR-gamma	RXRG	0.0041
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0041
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0041
1192	Sulfotransferase 1A1	SULT1A1	0.0041
823	Fibroblast growth factor receptor 2	FGFR2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
814	Ryanodine receptor 1	RYR1	0.0039
6035	Nuclear receptor ROR-beta	RORB	0.0039
6034	Hydroxyindole O-methyltransferase	ASMT	0.0039
1541	Metalloproteinase	mmp20	0.0039
6036	Eosinophil peroxidase	EPX	0.0039
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0039
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
3932	Glutathione S-transferase A2	GSTA2	0.0039
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0039
1291	cAMP response element-binding protein	CREB1	0.0038
1275	Estrogen sulfotransferase	SULT1E1	0.0038
6043	Putative G-protein coupled receptor 44	GPR44	0.0038
88	Retinoic acid receptor RXR-beta	RXRB	0.0038
85	Growth hormone receptor	GHR	0.0038
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0037
54	Prothrombin	F2	0.0037
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0037
163	D(1B) dopamine receptor	DRD5	0.0036
6432	Transporter	snf	0.0036
84	Nuclear receptor 0B1	NR0B1	0.0036
738	Monocarboxylate transporter 1	SLC16A1	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
1992	Vitamin D-binding protein	GC	0.0035
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
153	Dopamine beta-hydroxylase	DBH	0.0035
6149	Solute carrier family 22 member 10	SLC22A10	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
319	Opioid receptor, sigma 1	OPRS1	0.0034
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0034
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0034
765	Indoleamine 2,3-dioxygenase	IDO1	0.0034
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0034
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0034
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0034
24	Thymidylate synthase	TMP1	0.0034
359	Thymidylate synthase	TYMS	0.0034
2626	Thymidylate synthase	thyA	0.0034
2729	Thymidylate synthase	thyA	0.0034
5352	Thymidylate synthase	THYA	0.0034
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0033
518	Peroxidase/catalase T	katG	0.0033
558	Solute carrier family 12 member 1	SLC12A1	0.0033
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
1630	Integrin beta-2	ITGB2	0.0032
459	Retinoic acid receptor RXR-alpha	RXRA	0.0032
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0032
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0032
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0032
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0032
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
4203	Histamine N-methyltransferase	HNMT	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
5300	Antigen peptide transporter 1	TAP1	0.0031
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0031
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0031
7	Nitric oxide synthase, inducible	NOS2	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
106	Cannabinoid receptor 2	CNR2	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
1256	5-hydroxytryptamine 6 receptor	HTR6	0.003
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.003
6174	50S ribosomal protein L32	rpmF	0.003
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.003
1196	Complement decay-accelerating factor	CD55	0.0029
251	Alcohol dehydrogenase 1A	ADH1A	0.0029
6146	High affinity copper uptake protein 1	SLC31A1	0.0029
4122	Histone deacetylase 2	HDAC2	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0028
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0028
131	Synaptic vesicular amine transporter	SLC18A2	0.0028
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
820	Glycine receptor subunit alpha-2	GLRA2	0.0027
5787	Angiopoietin-1 receptor	TEK	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0027
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0027
904	Glutathione S-transferase P	GSTP1	0.0027
634	Squalene monooxygenase	SQLE	0.0027
7196	Squalene monooxygenase	ERG1	0.0027
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0027
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0027
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
444	Alcohol dehydrogenase 1B	ADH1B	0.0026
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0026
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0026
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0026
2808	Chloramphenicol acetyltransferase 3	cat3	0.0026
165	FL cytokine receptor	FLT3	0.0025
239	Coagulation factor X	F10	0.0025
1629	Transcription factor AP-1	JUN	0.0025
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0025
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0025
5798	Mitogen-activated protein kinase 11	MAPK11	0.0025
1648	Elastin	ELN	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
267	Plasminogen activator inhibitor 1	SERPINE1	0.0024
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
3937	Fatty-acid amide hydrolase	FAAH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3808	Dihydropteroate synthase 2	folP2	0.0023
3601	Dihydropteroate synthase 1	folP1	0.0023
3807	Dihydropteroate synthase 1	folP1	0.0023
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0023
2417	Chloramphenicol acetyltransferase	cat	0.0023
3278	Chloramphenicol acetyltransferase	cat	0.0023
2810	Dr hemagglutinin structural subunit	draA	0.0023
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0023
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0023
1353	DNA topoisomerase 1	TOP1	0.0023
3552	DNA topoisomerase 1	topA	0.0023
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0023
1262	Corticotropin-lipotropin	POMC	0.0023
517	Alcohol dehydrogenase 1C	ADH1C	0.0022
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0022
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0022
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0022
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0022
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0022
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0022
936	Ephrin type-A receptor 2	EPHA2	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
16	Adenosine A1 receptor	ADORA1	0.0022
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0022
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0022
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0022
469	Annexin A1	ANXA1	0.0022
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0022
6221	Steroid hormone receptor ERR1	ESRRA	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
5934	Cytochrome P450 26A1	CYP26A1	0.0022
1050	Bile salt sulfotransferase	SULT2A1	0.0022
2232	Interleukin-5	IL5	0.0022
164	Histamine H4 receptor	HRH4	0.0021
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0021
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0021
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0021
1178	Adenosine A2a receptor	ADORA2A	0.0021
1039	Histone deacetylase 9	HDAC9	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
719	Retinoic acid receptor responder protein 1	RARRES1	0.002
770	Retinoic acid-induced protein 3	GPRC5A	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.002
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.002
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.002
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.002
4311	tRNA	TRDMT1	0.002
4325	tRNA	trmD	0.002
4328	tRNA	trmD	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
976	Platelet glycoprotein IX	GP9	0.0019
6167	Organic solute transporter subunit beta	OSTB	0.0019
6166	Organic solute transporter subunit alpha	OSTA	0.0019
4103	Proteasome subunit beta type 2	PSMB2	0.0019
4102	Proteasome subunit beta type 5	PSMB5	0.0019
4101	Proteasome subunit beta type 1	PSMB1	0.0019
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
273	Apoptosis regulator Bcl-2	BCL2	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0019
3639	Thymidine phosphorylase	deoA	0.0019
3936	Thymidine phosphorylase	TYMP	0.0019
4217	Telomerase reverse transcriptase	TERT	0.0019
3426	Glutamine synthetase	glnA	0.0019
3987	Glutamine synthetase	GLUL	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
291	Nitric-oxide synthase, endothelial	NOS3	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0018
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
1253	Interferon gamma	IFNG	0.0018
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
683	Potassium transporter	GK0582	0.0018
569	Retinal dehydrogenase 2	ALDH1A2	0.0018
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
896	Glutathione S-transferase Mu 1	GSTM1	0.0017
4773	Deoxycytidine kinase	DCK	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
611	Retinal dehydrogenase 1	ALDH1A1	0.0017
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0017
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0017
1268	Neuropeptide S receptor	NPSR1	0.0017
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0017
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0016
1517	Beta-3 adrenergic receptor	ADRB3	0.0016
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0016
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0016
6044	Serum paraoxonase/lactonase 3	PON3	0.0016
173	Toll-like receptor 7	TLR7	0.0016
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0016
751	Potassium channel subfamily K member 6	KCNK6	0.0016
3233	Bile acid receptor	NR1H4	0.0015
33	Cystine/glutamate transporter	SLC7A11	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6073	Potassium channel subfamily K member 9	KCNK9	0.0015
6072	Potassium channel subfamily K member 3	KCNK3	0.0015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0015
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0015
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0015
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0015
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0015
572	Integrin alpha-L	ITGAL	0.0015
2320	Thymidine kinase, cytosolic	TK1	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
172	Potassium channel subfamily K member 1	KCNK1	0.0014
1864	RET proto-oncogene	RET	0.0014
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0014
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0014
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
65	Matrix metalloproteinase-9	Not Available	0.0014
2300	Lysozyme	E	0.0014
3633	Lysozyme	R	0.0014
5597	Lysozyme	17	0.0014
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0014
908	Glutathione S-transferase theta-1	GSTT1	0.0013
162	Retinoic acid receptor gamma-1	RARG	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
6218	Pannexin-1	PANX1	0.0013
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0013
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0013
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
2021	Thrombomodulin	THBD	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
605	Fumarate reductase flavoprotein subunit	frdA	0.0012
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0012
3673	Fumarate reductase flavoprotein subunit	fccA	0.0012
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0012
6549	Fumarate reductase flavoprotein subunit	frdA	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
5924	Microtubule-associated protein 4	MAP4	0.0012
5923	Microtubule-associated protein tau	MAPT	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0012
6163	Copper-transporting ATPase 2	ATP7B	0.0012
6165	Copper-transporting ATPase 1	ATP7A	0.0012
2207	Rhodopsin	RHO	0.0011
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0011
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
1374	Natriuretic peptides B	NPPB	0.0011
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0011
1827	Gap junction alpha-1 protein	GJA1	0.0011
1908	Vascular cell adhesion protein 1	VCAM1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0009
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0009
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
6168	Solute carrier family 22 member 16	SLC22A16	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
6042	Prostaglandin reductase 2	PTGR2	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
2298	Cytochrome P450-cam	camC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
76	Nitric-oxide synthase, brain	NOS1	0.0009
3404	Exotoxin A	eta	0.0008
1792	Tissue-type plasminogen activator	PLAT	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
489	Monocarboxylate transporter 2	SLC16A7	0.0008
1867	Major prion protein	PRNP	0.0008
3221	Cytochrome c4	cc4	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
1025	Aquaporin-1	AQP1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
1313	Lactoylglutathione lyase	GLO1	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
1507	Cytochrome c	CYCS	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
144	Hemoglobin subunit alpha	HBA1	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
4225	Uridine phosphorylase 1	UPP1	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
3957	Adenosine deaminase	ADA	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
4192	DNA topoisomerase 2-beta	TOP2B	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4916	Cyanoglobin	glbN	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4984	Neuroglobin	NGB	0.0006
4943	Cytochrome c6	petJ	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
3116	Bacterioferritin	bfr	0.0006
4906	Bacterioferritin	bfr	0.0006
4965	Bacterioferritin	bfr	0.0006
4910	Cytoglobin	CYGB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
5000	HemO	hemO	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4909	CooA protein	cooA	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4961	Hemophore HasA	hasA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4972	P450cin	cinA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
3093	Catalase HPII	katE	0.0006
4952	Catalase/peroxidase	katA	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0004
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
810	Heme oxygenase 1	HMOX1	0.0003
3391	Heme oxygenase 1	pbsA1	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB04938 - Ospemifene

Targets

Enzymes

Predictions