DT-Web: DB00796

Identification

Name

Candesartan

Accession Number

DB00796 (APRD00420)

Type

small molecule

Description

Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

440.454

Groups

approved

Monoisotopic Weight

440.159688536

Pharmacology

Indication

May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Candesartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors.

Mechanism of action

Candesartan selectively blocks the binding of angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands. This inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects of angiotensin II and results in an overall decrease in blood pressure. Candesartan is greater than 10,000 times more selective for AT1 than AT2. Inhibition of aldosterone secretion may increase sodium and water excretion while decreasing potassium excretion.

Absorption

Following administration of the candesartan cilexetil prodrug, the absolute bioavailability of candesartan was estimated to be 15%. Food with a high fat content has no affect on the bioavailability of candesartan from candesartan cilexetil.

Protein binding

Candesartan is highly bound to plasma proteins (>99%) and does not penetrate red blood cells.

Biotransformation

The prodrug candesartan cilexetil undergoes rapid and complete ester hydrolysis in the intestinal wall to form the active drug, candesartan. Elimination of candesartan is primarily as unchanged drug in the urine and, by the biliary route, in the feces. Minor hepatic metabolism of candesartan (<20%)occurs by O-deethylation via cytochrome P450 2C9 to form an inactive metabolite. Candesartan undergoes N-glucuronidation in the tetrazole ring by uridine diphosphate glucuronosyltransferase 1A3 (UGT1A3). O-glucuronidation may also occur. 75% of candesartan is excreted as unchanged drug in urine and feces.

Route of elimination

When candesartan is administered orally, about 26% of the dose is excreted unchanged in urine. Candesartan is mainly excreted unchanged in urine and feces (via bile).

Toxicity

No lethality was observed in acute toxicity studies in mice, rats and dogs given single oral doses of up to 2000 mg/kg of candesartan cilexetil or in rats given single oral doses of up to 2000 mg/kg of candesartan cilexetil in combination with 1000 mg/kg of hydrochlorothiazide. In mice given single oral doses of the primary metabolite, candesartan, the minimum lethal dose was greater than 1000 mg/kg but less than 2000 mg/kg.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Amiloride	Increased risk of hyperkalemia
Drospirenone	Increased risk of hyperkalemia
Lithium	The ARB increases serum levels of lithium
Potassium	Increased risk of hyperkalemia
Spironolactone	Increased risk of hyperkalemia
Tobramycin	Increased risk of nephrotoxicity
Trandolapril	The angiotensin II receptor blocker, Candesartan, may increase the adverse effects of Trandolapril.
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Triamterene	Increased risk of hyperkalemia

Food Interactions

Take without regard to meals.
Administer on a regular basis, at about the same time each day.

Type-1 angiotensin II receptor
Name	Type-1 angiotensin II receptor
Gene Name	AGTR1
Pharmacological action	yes
Actions	antagonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Cervenka L, Navar LG: Renal responses of the nonclipped kidney of two-kidney/one-clip Goldblatt hypertensive rats to type 1 angiotensin II receptor blockade with candesartan. J Am Soc Nephrol. 1999 Jan;10 Suppl 11:S197-201. - Pubmed Malmqvist K, Kahan T, Dahl M: Angiotensin II type 1 (AT1) receptor blockade in hypertensive women: benefits of candesartan cilexetil versus enalapril or hydrochlorothiazide. Am J Hypertens. 2000 May;13(5 Pt 1):504-11. - Pubmed Wada T, Inada Y, Ojima M, Sanada T, Shibouta Y, Nishikawa K: Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats. Hypertens Res. 1996 Jun;19(2):75-81. - Pubmed Engelhorn T, Doerfler A, Heusch G, Schulz R: Reduction of cerebral infarct size by the AT1-receptor blocker candesartan, the HMG-CoA reductase inhibitor rosuvastatin and their combination. An experimental study in rats. Neurosci Lett. 2006 Oct 2;406(1-2):92-6. Epub 2006 Aug 9. - Pubmed Caballero-George C, Vanderheyden PM, Solis PN, Gupta MP, Pieters L, Vauquelin G, Vlietinck A: In vitro effect of sanguinarine alkaloid on binding of [3H]candesartan to the human angiotensin AT1 receptor. Eur J Pharmacol. 2003 Jan 5;458(3):257-62. - Pubmed McInnes GT, O'Kane KP, Istad H, Keinanen-Kiukaanniemi S, Van Mierlo HF: Comparison of the AT1-receptor blocker, candesartan cilexetil, and the ACE inhibitor, lisinopril, in fixed combination with low dose hydrochlorothiazide in hypertensive patients. J Hum Hypertens. 2000 Apr;14(4):263-9. - Pubmed Vauquelin G, Fierens F, Van Liefde I: Long-lasting angiotensin type 1 receptor binding and protection by candesartan: comparison with other biphenyl-tetrazole sartans. J Hypertens Suppl. 2006 Mar;24(1):S23-30. - Pubmed Mendis B, Page SR: Candesartan: widening indications for this angiotensin II receptor blocker? Expert Opin Pharmacother. 2009 Aug;10(12):1995-2007. - Pubmed Meredith PA: Candesartan cilexetil--a review of effects on cardiovascular complications in hypertension and chronic heart failure. Curr Med Res Opin. 2007 Jul;23(7):1693-705. - Pubmed Baguet JP, Barone-Rochette G, Neuder Y: Candesartan cilexetil in the treatment of chronic heart failure. Vasc Health Risk Manag. 2009;5(1):257-64. Epub 2009 Apr 8. - Pubmed
DTHybrid score	0.7058

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	McClellan KJ, Goa KL: Candesartan cilexetil. A review of its use in essential hypertension. Drugs. 1998 Nov;56(5):847-69. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4288
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed
DTHybrid score	0.3119
UDP-glucuronosyltransferase 1-3
Name	UDP-glucuronosyltransferase 1-3
Gene Name	UGT1A3
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.2044
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.4748

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. - Pubmed
DTHybrid score	0.3251

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.2789
6016	Cytochrome P450 2C19	CYP2C19	0.201
290	Prostaglandin G/H synthase 2	PTGS2	0.1807
4119	Cytochrome P450 2D6	CYP2D6	0.1611
4200	Cytochrome P450 1A2	CYP1A2	0.1513
4118	Cytochrome P450 3A5	CYP3A5	0.1183
587	Serum albumin	ALB	0.1082
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1074
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1009
6030	Cytochrome P450 2B6	CYP2B6	0.0975
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0954
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0947
6107	Cytochrome P450 3A7	CYP3A7	0.079
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0787
6013	Cytochrome P450 2E1	CYP2E1	0.074
1729	Solute carrier family 22 member 6	SLC22A6	0.0707
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0678
5852	Type-2 angiotensin II receptor	AGTR2	0.0627
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0625
5718	Cytochrome P450 2A6	CYP2A6	0.0622
6024	Cytochrome P450 1A1	CYP1A1	0.058
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0523
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0472
6106	Cytochrome P450 2C18	CYP2C18	0.0401
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.039
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0375
862	Multidrug resistance-associated protein 1	ABCC1	0.0372
2164	Multidrug resistance-associated protein 4	ABCC4	0.0349
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0333
6142	Solute carrier family 22 member 8	SLC22A8	0.0303
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.03
275	Arachidonate 5-lipoxygenase	ALOX5	0.0298
492	Histamine H1 receptor	HRH1	0.0297
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0294
1629	Transcription factor AP-1	JUN	0.0293
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0277
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0277
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0238
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0232
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0229
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0223
776	Bile salt export pump	ABCB11	0.0221
1898	Cytochrome P450 1B1	CYP1B1	0.0221
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.022
6143	Solute carrier family 22 member 7	SLC22A7	0.022
5880	Thrombopoietin receptor	MPL	0.0216
3811	Cytochrome P450 19A1	CYP19A1	0.0212
824	Sodium-dependent serotonin transporter	SLC6A4	0.0209
1024	Solute carrier family 22 member 11	SLC22A11	0.0207
6145	Solute carrier family 22 member 1	SLC22A1	0.0205
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0205
136	Estrogen receptor	ESR1	0.0202
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0201
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0194
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0193
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0188
6102	Arylamine N-acetyltransferase 2	NAT2	0.0182
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0182
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0181
467	Delta-type opioid receptor	OPRD1	0.0181
696	Kappa-type opioid receptor	OPRK1	0.0181
847	Mu-type opioid receptor	OPRM1	0.0179
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0177
6144	Solute carrier family 22 member 2	SLC22A2	0.0177
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0176
831	D(2) dopamine receptor	DRD2	0.0172
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0165
556	Alpha-1A adrenergic receptor	ADRA1A	0.0165
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0157
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0155
1757	Myeloperoxidase	MPO	0.0154
811	Translocator protein	TSPO	0.0152
891	Dihydropteroate synthase	folP	0.0152
5359	Dihydropteroate synthase	folP	0.0152
7175	Dihydropteroate synthase	sulI	0.0152
871	Glucocorticoid receptor	NR3C1	0.0151
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.015
6141	Sodium/bile acid cotransporter	SLC10A1	0.015
118	Organic cation/carnitine transporter 2	SLC22A5	0.0149
3923	Cholinesterase	BCHE	0.0146
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0141
6085	Fatty acid-binding protein, intestinal	FABP2	0.0137
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0135
122	P2Y purinoceptor 12	P2RY12	0.0134
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0134
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0134
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0126
731	HIV-1 protease	HIV-1 protease	0.0126
766	Beta-2 adrenergic receptor	ADRB2	0.0125
738	Monocarboxylate transporter 1	SLC16A1	0.0123
6182	Cytochrome P450 2J2	CYP2J2	0.0122
260	Cytochrome P450 51	ERG11	0.0121
761	Cytochrome P450 51	ERG11	0.0121
3163	Cytochrome P450 51	cyp51	0.0121
146	Androgen receptor	AR	0.012
373	Transthyretin	TTR	0.0119
193	Beta-1 adrenergic receptor	ADRB1	0.0118
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0118
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0115
1507	Cytochrome c	CYCS	0.0115
6136	Multidrug resistance-associated protein 5	ABCC5	0.0113
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0112
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.011
459	Retinoic acid receptor RXR-alpha	RXRA	0.0109
465	Calmodulin	CALM1	0.0107
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0107
3941	Amine oxidase [flavin-containing] A	MAOA	0.0105
6137	Multidrug resistance-associated protein 6	ABCC6	0.0104
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0104
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0104
817	DNA topoisomerase 2-alpha	TOP2A	0.0104
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0103
4604	Liver carboxylesterase 1	CES1	0.0103
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0102
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0102
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0102
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0102
632	Alpha-1B adrenergic receptor	ADRA1B	0.0102
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0102
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0097
504	Mast/stem cell growth factor receptor	KIT	0.0097
844	Epidermal growth factor receptor	EGFR	0.0095
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0095
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0092
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0092
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0092
6147	Solute carrier family 22 member 3	SLC22A3	0.0091
6031	Cytochrome P450 3A43	CYP3A43	0.009
23	D(1A) dopamine receptor	DRD1	0.009
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.009
468	Cytochrome P450 4A11	CYP4A11	0.009
3939	Amine oxidase [flavin-containing] B	MAOB	0.0089
1192	Sulfotransferase 1A1	SULT1A1	0.0088
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0088
4116	Dihydropteroate synthetase	Not Available	0.0087
869	Estrogen receptor beta	ESR2	0.0087
318	Alpha-2A adrenergic receptor	ADRA2A	0.0087
952	Dipeptidyl peptidase 4	DPP4	0.0086
6148	Multidrug resistance-associated protein 7	ABCC10	0.0086
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0086
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0086
3312	Fatty acid-binding protein, brain	FABP7	0.0086
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0086
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0084
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0082
789	Alpha-1D adrenergic receptor	ADRA1D	0.0082
1760	Aminopeptidase N	ANPEP	0.008
6843	Aminopeptidase N	pepN	0.008
4120	NADPH--cytochrome P450 reductase	POR	0.008
713	Sodium-dependent dopamine transporter	SLC6A3	0.008
1630	Integrin beta-2	ITGB2	0.0079
380	Cytochrome P450 17A1	CYP17A1	0.0079
777	Tumor necrosis factor	TNF	0.0079
117	Sterol O-acyltransferase 1	SOAT1	0.0079
365	Dihydrofolate reductase	DHFR	0.0078
2381	Dihydrofolate reductase	DFR1	0.0078
2833	Dihydrofolate reductase	Not Available	0.0078
2931	Dihydrofolate reductase	folA	0.0078
3544	Dihydrofolate reductase	folA	0.0078
3682	Dihydrofolate reductase	folA	0.0078
6642	Dihydrofolate reductase	folA	0.0078
6756	Dihydrofolate reductase	dfrA	0.0078
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0077
427	Substance-P receptor	TACR1	0.0077
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0077
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0076
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0075
614	Progesterone receptor	PGR	0.0075
2021	Thrombomodulin	THBD	0.0074
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0074
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0073
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0072
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0072
1648	Elastin	ELN	0.0072
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0072
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0071
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0071
273	Apoptosis regulator Bcl-2	BCL2	0.0071
185	Vasopressin V1a receptor	AVPR1A	0.0071
558	Solute carrier family 12 member 1	SLC12A1	0.007
322	Vasopressin V2 receptor	AVPR2	0.0069
24	Thymidylate synthase	TMP1	0.0069
359	Thymidylate synthase	TYMS	0.0069
2626	Thymidylate synthase	thyA	0.0069
2729	Thymidylate synthase	thyA	0.0069
5352	Thymidylate synthase	THYA	0.0069
407	Vascular endothelial growth factor receptor 2	KDR	0.0068
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0068
833	Organic cation/carnitine transporter 1	SLC22A4	0.0067
29	Tubulin beta-1 chain	TUBB1	0.0067
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0066
4122	Histone deacetylase 2	HDAC2	0.0066
130	Prostacyclin synthase	PTGIS	0.0065
6044	Serum paraoxonase/lactonase 3	PON3	0.0064
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
244	Angiotensin-converting enzyme	ACE	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
3809	Estrogen-related receptor gamma	ESRRG	0.0063
3810	Catechol O-methyltransferase	COMT	0.0061
6220	Aryl hydrocarbon receptor	AHR	0.0061
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0061
756	Sex hormone-binding globulin	SHBG	0.0061
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0061
124	Histamine H2 receptor	HRH2	0.006
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.006
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.006
1541	Metalloproteinase	mmp20	0.006
737	Mineralocorticoid receptor	NR3C2	0.0059
572	Integrin alpha-L	ITGAL	0.0059
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0059
1275	Estrogen sulfotransferase	SULT1E1	0.0058
6103	Arylamine N-acetyltransferase 1	NAT1	0.0058
1039	Histone deacetylase 9	HDAC9	0.0058
26	Vascular endothelial growth factor receptor 3	FLT4	0.0057
161	Tubulin beta chain	TUBB	0.0057
312	Tubulin beta chain	TUB2	0.0057
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0057
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0056
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0056
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0056
703	NADPH azoreductase	azr	0.0056
4103	Proteasome subunit beta type 2	PSMB2	0.0056
4102	Proteasome subunit beta type 5	PSMB5	0.0056
4101	Proteasome subunit beta type 1	PSMB1	0.0056
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0056
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0056
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0055
32	Vascular endothelial growth factor receptor 1	FLT1	0.0055
7	Nitric oxide synthase, inducible	NOS2	0.0054
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0054
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0053
88	Retinoic acid receptor RXR-beta	RXRB	0.0053
823	Fibroblast growth factor receptor 2	FGFR2	0.0053
638	D(3) dopamine receptor	DRD3	0.0053
850	Vasopressin V1b receptor	AVPR1B	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
267	Plasminogen activator inhibitor 1	SERPINE1	0.0052
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0052
6138	Multidrug resistance protein 3	ABCB4	0.0052
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0051
1792	Tissue-type plasminogen activator	PLAT	0.0051
474	Acetylcholinesterase	ACHE	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0051
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.005
1353	DNA topoisomerase 1	TOP1	0.005
3552	DNA topoisomerase 1	topA	0.005
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0049
6033	High affinity interleukin-8 receptor A	CXCR1	0.0049
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0049
6149	Solute carrier family 22 member 10	SLC22A10	0.0049
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0049
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0049
6014	Cytochrome P450 2A13	CYP2A13	0.0048
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0048
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0048
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0048
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0048
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0048
1010	Cytochrome P450 51A1	CYP51A1	0.0048
6221	Steroid hormone receptor ERR1	ESRRA	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0047
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0046
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0045
716	5-hydroxytryptamine 7 receptor	HTR7	0.0045
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
106	Cannabinoid receptor 2	CNR2	0.0045
629	Alpha-2B adrenergic receptor	ADRA2B	0.0045
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0045
94	5-hydroxytryptamine 4 receptor	HTR4	0.0045
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0045
634	Squalene monooxygenase	SQLE	0.0044
7196	Squalene monooxygenase	ERG1	0.0044
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0044
295	Carbonic anhydrase 1	CA1	0.0044
49	Endothelin B receptor	EDNRB	0.0044
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0043
68	Cannabinoid receptor 1	CNR1	0.0043
489	Monocarboxylate transporter 2	SLC16A7	0.0043
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0043
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0043
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0042
1050	Bile salt sulfotransferase	SULT2A1	0.0042
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0042
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0042
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0042
319	Opioid receptor, sigma 1	OPRS1	0.0042
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0042
1618	High affinity nerve growth factor receptor	NTRK1	0.0042
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0041
183	Vascular endothelial growth factor A	VEGFA	0.0041
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0041
578	Endothelin-1 receptor	EDNRA	0.0041
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0041
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0041
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0041
528	5-hydroxytryptamine 1E receptor	HTR1E	0.004
5300	Antigen peptide transporter 1	TAP1	0.004
2981	Phospholipase A2, membrane associated	PLA2G2A	0.004
6043	Putative G-protein coupled receptor 44	GPR44	0.0039
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0039
921	Glutamate receptor 2	GRIA2	0.0039
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0039
3808	Dihydropteroate synthase 2	folP2	0.0039
3601	Dihydropteroate synthase 1	folP1	0.0039
3807	Dihydropteroate synthase 1	folP1	0.0039
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0039
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0039
1178	Adenosine A2a receptor	ADORA2A	0.0038
162	Retinoic acid receptor gamma-1	RARG	0.0037
1852	Microtubule-associated protein 2	MAP2	0.0037
6146	High affinity copper uptake protein 1	SLC31A1	0.0037
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0037
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0036
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0036
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0036
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0036
6174	50S ribosomal protein L32	rpmF	0.0036
477	DNA topoisomerase 4 subunit A	parC	0.0035
886	DNA topoisomerase 4 subunit A	parC	0.0035
6226	DNA topoisomerase 4 subunit A	parC	0.0035
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0035
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0035
1656	CYP2B protein	CYP2B	0.0035
780	Retinoic acid receptor RXR-gamma	RXRG	0.0035
2449	Tubulin alpha-3 chain	TUBA1A	0.0035
404	DNA gyrase subunit A	gyrA	0.0035
6224	DNA gyrase subunit A	gyrA	0.0035
592	Carbonic anhydrase 4	CA4	0.0035
54	Prothrombin	F2	0.0035
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0035
239	Coagulation factor X	F10	0.0034
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0034
594	Thyroxine-binding globulin	SERPINA7	0.0034
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0033
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0033
3947	Xanthine dehydrogenase/oxidase	XDH	0.0033
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0033
723	Cytosolic phospholipase A2	PLA2G4A	0.0033
2207	Rhodopsin	RHO	0.0032
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
229	Retinoic acid receptor beta	RARB	0.0032
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0032
2499	Tubulin beta-2C chain	TUBB2C	0.0031
730	Retinoic acid receptor alpha	RARA	0.0031
758	Thyroid hormone receptor alpha	THRA	0.0031
469	Annexin A1	ANXA1	0.0031
165	FL cytokine receptor	FLT3	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
2539	Tubulin alpha-1 chain	TUBA4A	0.0031
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0031
3856	Fibroblast growth factor receptor 3	FGFR3	0.003
904	Glutathione S-transferase P	GSTP1	0.003
518	Peroxidase/catalase T	katG	0.003
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
1714	Mitogen-activated protein kinase 3	MAPK3	0.0029
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0029
378	Alpha-2C adrenergic receptor	ADRA2C	0.0029
6500	Phospholipase A2	PLA2G1B	0.0029
683	Potassium transporter	GK0582	0.0029
1374	Natriuretic peptides B	NPPB	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
1827	Gap junction alpha-1 protein	GJA1	0.0029
1908	Vascular cell adhesion protein 1	VCAM1	0.0029
16	Adenosine A1 receptor	ADORA1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
2112	Toll-like receptor 9	TLR9	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
346	Thyroid hormone receptor beta-1	THRB	0.0028
1932	Apolipoprotein E	APOE	0.0028
908	Glutathione S-transferase theta-1	GSTT1	0.0028
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
4237	50S ribosomal protein L22	rplV	0.0027
4192	DNA topoisomerase 2-beta	TOP2B	0.0027
818	50S ribosomal protein L10	rplJ	0.0026
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0026
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0026
571	Melatonin receptor type 1A	MTNR1A	0.0026
362	Melatonin receptor type 1B	MTNR1B	0.0026
357	Carbonic anhydrase 2	CA2	0.0026
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6126	Carbonic anhydrase 7	CA7	0.0026
33	Cystine/glutamate transporter	SLC7A11	0.0026
992	Protein tyrosine kinase 2 beta	PTK2B	0.0026
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0026
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0026
84	Nuclear receptor 0B1	NR0B1	0.0025
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0025
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0025
3639	Thymidine phosphorylase	deoA	0.0025
3936	Thymidine phosphorylase	TYMP	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
1196	Complement decay-accelerating factor	CD55	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
432	D(4) dopamine receptor	DRD4	0.0025
5787	Angiopoietin-1 receptor	TEK	0.0025
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0024
482	Glycine receptor subunit alpha-1	GLRA1	0.0024
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0024
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0024
199	Monocarboxylate transporter 8	SLC16A2	0.0024
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0024
759	Free fatty acid receptor 1	FFAR1	0.0024
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0024
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
3611	Cytidine deaminase	cdd	0.0024
3707	Cytidine deaminase	cdd	0.0024
4211	Cytidine deaminase	CDA	0.0024
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0024
5923	Microtubule-associated protein tau	MAPT	0.0024
5924	Microtubule-associated protein 4	MAP4	0.0024
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
6824	Tyrosine-protein kinase Lyn	LYN	0.0023
976	Platelet glycoprotein IX	GP9	0.0023
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0023
1291	cAMP response element-binding protein	CREB1	0.0023
1650	Heme carrier protein 1	SLC46A1	0.0022
4217	Telomerase reverse transcriptase	TERT	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
814	Ryanodine receptor 1	RYR1	0.0022
2808	Chloramphenicol acetyltransferase 3	cat3	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
3086	Plasmepsin-2	Not Available	0.0022
4210	Toll-like receptor 4	TLR4	0.0022
3932	Glutathione S-transferase A2	GSTA2	0.0021
1262	Corticotropin-lipotropin	POMC	0.0021
1864	RET proto-oncogene	RET	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0021
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0021
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0021
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0021
1053	BC269730_2	FADS1	0.0021
1395	Sodium/calcium exchanger 1	SLC8A1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0021
174	Sigma 1-type opioid receptor	SIGMAR1	0.0021
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0021
6459	Glycodelin	PAEP	0.002
6048	Troponin C, skeletal muscle	TNNC2	0.002
2417	Chloramphenicol acetyltransferase	cat	0.002
3278	Chloramphenicol acetyltransferase	cat	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
4773	Deoxycytidine kinase	DCK	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
564	Cellular retinoic acid-binding protein 1	CRABP1	0.002
4311	tRNA	TRDMT1	0.002
4325	tRNA	trmD	0.002
4328	tRNA	trmD	0.002
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.002
2810	Dr hemagglutinin structural subunit	draA	0.002
153	Dopamine beta-hydroxylase	DBH	0.002
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.002
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.002
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0019
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0019
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0019
605	Fumarate reductase flavoprotein subunit	frdA	0.0019
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0019
3673	Fumarate reductase flavoprotein subunit	fccA	0.0019
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0019
6549	Fumarate reductase flavoprotein subunit	frdA	0.0019
936	Ephrin type-A receptor 2	EPHA2	0.0019
581	Cytochrome P450 2R1	CYP2R1	0.0019
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0019
3957	Adenosine deaminase	ADA	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6131	Carbonic anhydrase 14	CA14	0.0019
2236	Casein kinase II subunit alpha	CSNK2A1	0.0018
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0018
1992	Vitamin D-binding protein	GC	0.0018
164	Histamine H4 receptor	HRH4	0.0018
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0018
5798	Mitogen-activated protein kinase 11	MAPK11	0.0018
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0018
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0018
2320	Thymidine kinase, cytosolic	TK1	0.0017
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0017
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0017
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0017
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
6042	Prostaglandin reductase 2	PTGR2	0.0017
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0017
768	FK506-binding protein 1A	FKBP1A	0.0017
6020	Aldehyde oxidase	AOX1	0.0017
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0017
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0017
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0016
6837	Serine/threonine-protein kinase 17B	STK17B	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
4226	Uridine phosphorylase 2	UPP2	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0016
2216	Fibroblast growth factor receptor 4	FGFR4	0.0016
822	Aldose reductase	AKR1B1	0.0016
6218	Pannexin-1	PANX1	0.0015
5934	Cytochrome P450 26A1	CYP26A1	0.0015
6755	Poliovirus receptor	PVR	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
1517	Beta-3 adrenergic receptor	ADRB3	0.0015
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
751	Potassium channel subfamily K member 6	KCNK6	0.0015
4225	Uridine phosphorylase 1	UPP1	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0014
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0014
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
268	Adenosine A2b receptor	ADORA2B	0.0014
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0014
172	Potassium channel subfamily K member 1	KCNK1	0.0014
413	Amidophosphoribosyltransferase	PPAT	0.0014
2515	Amidophosphoribosyltransferase	purF	0.0014
3714	Amidophosphoribosyltransferase	purF	0.0014
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0014
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0014
2232	Interleukin-5	IL5	0.0014
3221	Cytochrome c4	cc4	0.0014
1593	Mucin-2	MUC2	0.0014
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0013
1313	Lactoylglutathione lyase	GLO1	0.0013
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0013
856	Vitamin D3 receptor	VDR	0.0013
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0013
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0013
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0013
6167	Organic solute transporter subunit beta	OSTB	0.0013
6166	Organic solute transporter subunit alpha	OSTA	0.0013
163	D(1B) dopamine receptor	DRD5	0.0013
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0013
6432	Transporter	snf	0.0013
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0013
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
569	Retinal dehydrogenase 2	ALDH1A2	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0012
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0012
461	Glycine receptor subunit alpha-3	GLRA3	0.0012
284	DNA-directed RNA polymerase beta chain	rpoB	0.0012
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0012
6151	Monocarboxylate transporter 10	SLC16A10	0.0012
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0012
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0012
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0012
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0012
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0012
6859	Protein S100-A4	S100A4	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
611	Retinal dehydrogenase 1	ALDH1A1	0.0012
760	Fibroblast growth factor 1	FGF1	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
3913	Glutamic acid decarboxylase	GAD65	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0011
232	Corticosteroid-binding globulin	SERPINA6	0.0011
131	Synaptic vesicular amine transporter	SLC18A2	0.0011
144	Hemoglobin subunit alpha	HBA1	0.001
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.001
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.001
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.001
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.001
1483	Membrane copper amine oxidase	AOC3	0.001
3937	Fatty-acid amide hydrolase	FAAH	0.001
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.001
563	Thyroid peroxidase	TPO	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
291	Nitric-oxide synthase, endothelial	NOS3	0.0009
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0009
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0009
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0009
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0009
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0009
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0009
735	Alanine aminotransferase 1	GPT	0.0009
3904	Alanine aminotransferase 2	GPT2	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0009
1341	Histamine H3 receptor	HRH3	0.0009
1525	Heparin-binding growth factor 2	FGF2	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0009
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0009
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0009
1569	G1/S-specific cyclin-D1	CCND1	0.0009
2240	Cell division protein kinase 2	CDK2	0.0009
444	Alcohol dehydrogenase 1B	ADH1B	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
1184	Interferon beta	IFNB1	0.0008
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0008
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0008
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0008
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0008
6211	Tubulin epsilon chain	TUBE1	0.0008
6212	Tubulin gamma-1 chain	TUBG1	0.0008
6210	Tubulin delta chain	TUBD1	0.0008
484	Tyrosine-protein kinase ABL2	ABL2	0.0008
6163	Copper-transporting ATPase 2	ATP7B	0.0008
6165	Copper-transporting ATPase 1	ATP7A	0.0008
76	Nitric-oxide synthase, brain	NOS1	0.0008
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4984	Neuroglobin	NGB	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
4961	Hemophore HasA	hasA	0.0008
4909	CooA protein	cooA	0.0008
5000	HemO	hemO	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4910	Cytoglobin	CYGB	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4972	P450cin	cinA	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4952	Catalase/peroxidase	katA	0.0008
3093	Catalase HPII	katE	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0008
3830	Calreticulin	CALR	0.0008
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0007
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
4692	A/G-specific adenine glycosylase	mutY	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
517	Alcohol dehydrogenase 1C	ADH1C	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
896	Glutathione S-transferase Mu 1	GSTM1	0.0006
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
442	Envelope glycoprotein	gp41	0.0006
4859	Envelope glycoprotein	env	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0006
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
2802	Endoglucanase G	celCCG	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
251	Alcohol dehydrogenase 1A	ADH1A	0.0006
1176	Mitogen-activated protein kinase 1	MAPK1	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
705	Glutamate receptor 1	GRIA1	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
4920	Peroxidase/catalase	katG	0.0006
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
828	Phenylalanine-4-hydroxylase	PAH	0.0006
3109	Phenylalanine-4-hydroxylase	phhA	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
4990	PpcA	ppcA	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
2230	Catalase	CAT	0.0005
3249	Catalase	katA	0.0005
3625	Catalase	katA	0.0005
4539	Catalase	katA	0.0005
4941	Catalase	katB	0.0005
2430	Chondroitinase B	cslB	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0005
1268	Neuropeptide S receptor	NPSR1	0.0005
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0005
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0004
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0004
6073	Potassium channel subfamily K member 9	KCNK9	0.0004
6072	Potassium channel subfamily K member 3	KCNK3	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
958	Insulin-like growth factor 1 receptor	IGF1R	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
6168	Solute carrier family 22 member 16	SLC22A16	0.0004
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
1243	Cathepsin D	CTSD	0.0003
810	Heme oxygenase 1	HMOX1	0.0003
3391	Heme oxygenase 1	pbsA1	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0003
1439	Lactotransferrin	LTF	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
2298	Cytochrome P450-cam	camC	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
2440	Endoglucanase F	celCCF	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00796 - Candesartan

Targets

Enzymes

Transporters

Predictions