DT-Web: DB00381

Identification

Name

Amlodipine

Accession Number

DB00381 (APRD00520)

Type

small molecule

Description

Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug's vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that amlodipine also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Amlodipine is used to treat hypertension and chronic stable angina.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

408.876

Groups

approved

Monoisotopic Weight

408.145199627

Pharmacology

Indication

For the treatment of hypertension and chronic stable angina.

Mechanism of action

Amlodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of amlodipine result in an overall decrease in blood pressure. Amlodipine is a long-acting CCB that may be used to treat mild to moderate essential hypertension and exertion-related angina (chronic stable angina). Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity causing cellular pH increases which may be involved in regulating intracelluar calcium influx through calcium channels.

Absorption

Amlodipine is slowly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached 6-12 hour following oral administration. Its estimated bioavailability is 64-90%. Absorption is not affected by food.

Protein binding

97.5%

Biotransformation

Hepatic. Metabolized extensively (90%) to inactive metabolites via the cytochrome P450 3A4 isozyme.

Route of elimination

Amlodipine is extensively (about 90%) converted to inactive metabolites via hepatic metabolism with 10% of the parent compound and 60% of the metabolites excreted in the urine.

Toxicity

Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Diltiazem	Diltiazem may increase the serum concentration of amlodipine. Concomitant therapy will result in additive hypotensive effects. Monitor for changes in the hypotensive effect of amlodipine if diltiazem is initiated, discontinued or dose changed.
Quinupristin	This combination presents an increased risk of toxicity
Tacrine	The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by Amlopidine, a CYP1A2 inhibitors. Monitor the efficacy and toxicity of Tacrine if Amlopidine is initiated, discontinued or if the dose is changed.
Telaprevir	Telaprevir inhibits the metabolism of amlodipine and concomitant therapy is contraindicated.
Telithromycin	Telithromycin may reduce clearance of Amlopidine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Amlopidine if Telithromycin is initiated, discontinued or dose changed.
Thiopental	The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Amlodipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Amlodipine if Thiopental is initiated, discontinued or dose changed.
Tipranavir	Tipranavir may decrease the metabolism and clearance of the calcium channel blocker, Amlopidine. Monitor for changes in Amlopidine therapeutic and toxic effects if Tipranavir is initiated, discontinued or dose changed.
Tizanidine	Amlopidine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Voriconazole	Voriconazole may increase the serum concentration of amlodipine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amlodipine if voriconazole is initiated, discontinued or dose changed.

Food Interactions

Take without regard to meals.
Avoid natural licorice.
Grapefruit down regulates post-translational expression of CYP3A4, the major metabolizing enzyme of amlodipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of amlodipine and may cause toxicity. Avoid grapefruit products while on this medication.

Voltage-dependent L-type calcium channel subunit alpha-1C
Name	Voltage-dependent L-type calcium channel subunit alpha-1C
Gene Name	CACNA1C
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
DTHybrid score	0.6745
Voltage-dependent calcium channel subunit alpha-2/delta-1
Name	Voltage-dependent calcium channel subunit alpha-2/delta-1
Gene Name	CACNA2D1
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
DTHybrid score	0.6455
Voltage-dependent L-type calcium channel subunit beta-2
Name	Voltage-dependent L-type calcium channel subunit beta-2
Gene Name	CACNB2
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
DTHybrid score	0.5809
Voltage-dependent L-type calcium channel subunit alpha-1D
Name	Voltage-dependent L-type calcium channel subunit alpha-1D
Gene Name	CACNA1D
Pharmacological action	yes
Actions	inhibitor
References	Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J: Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Mol Pharmacol. 2009 Feb;75(2):407-14. Epub 2008 Nov 24. - Pubmed
DTHybrid score	0.5712
Voltage-dependent L-type calcium channel subunit alpha-1S
Name	Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name	CACNA1S
Pharmacological action	yes
Actions	inhibitor
References	Peterson BZ, Catterall WA: Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore. Mol Pharmacol. 2006 Aug;70(2):667-75. Epub 2006 May 4. - Pubmed
DTHybrid score	0.6077
Voltage-dependent N-type calcium channel subunit alpha-1B
Name	Voltage-dependent N-type calcium channel subunit alpha-1B
Gene Name	CACNA1B
Pharmacological action	unknown
Actions	inhibitor
References	Furukawa T, Nukada T, Suzuki K, Fujita Y, Mori Y, Nishimura M, Yamanaka M: Voltage and pH dependent block of cloned N-type Ca2+ channels by amlodipine. Br J Pharmacol. 1997 Jul;121(6):1136-40. - Pubmed Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T: Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73. - Pubmed Miyashita Y, Furukawa T, Kamegaya E, Yoshii M, Nukada T: A region of N-type Ca(2+) channel critical for blockade by the dihydropyridine amlodipine. Eur J Pharmacol. 2010 Apr 25;632(1-3):14-22. Epub 2010 Jan 22. - Pubmed Murakami M, Nakagawasai O, Fujii S, Kameyama K, Murakami S, Hozumi S, Esashi A, Taniguchi R, Yanagisawa T, Tan-no K, Tadano T, Kitamura K, Kisara K: Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice. Eur J Pharmacol. 2001 May 11;419(2-3):175-81. - Pubmed Ogihara T, Kano T, Kakinuma C: Evaluation of the inhibitory effect of dihydropyridines on N-type calcium channel by virtual three-dimensional pharmacophore modeling. Arzneimittelforschung. 2009;59(6):283-8. - Pubmed Qu YL, Sugiyama K, Ohnuki T, Hattori K, Watanabe K, Nagatomo T: Comparison of binding affinities of omega-conotoxin and amlodipine to N-type Ca2+ channels in rat brain. Zhongguo Yao Li Xue Bao. 1998 Mar;19(2):97-100. - Pubmed
DTHybrid score	0.3321
Voltage-dependent calcium channel subunit alpha-2/delta-3
Name	Voltage-dependent calcium channel subunit alpha-2/delta-3
Gene Name	CACNA2D3
Pharmacological action	unknown
Actions	inhibitor
References	Furukawa T, Nukada T, Suzuki K, Fujita Y, Mori Y, Nishimura M, Yamanaka M: Voltage and pH dependent block of cloned N-type Ca2+ channels by amlodipine. Br J Pharmacol. 1997 Jul;121(6):1136-40. - Pubmed Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T: Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73. - Pubmed Miyashita Y, Furukawa T, Kamegaya E, Yoshii M, Nukada T: A region of N-type Ca(2+) channel critical for blockade by the dihydropyridine amlodipine. Eur J Pharmacol. 2010 Apr 25;632(1-3):14-22. Epub 2010 Jan 22. - Pubmed Murakami M, Nakagawasai O, Fujii S, Kameyama K, Murakami S, Hozumi S, Esashi A, Taniguchi R, Yanagisawa T, Tan-no K, Tadano T, Kitamura K, Kisara K: Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice. Eur J Pharmacol. 2001 May 11;419(2-3):175-81. - Pubmed Ogihara T, Kano T, Kakinuma C: Evaluation of the inhibitory effect of dihydropyridines on N-type calcium channel by virtual three-dimensional pharmacophore modeling. Arzneimittelforschung. 2009;59(6):283-8. - Pubmed Qu YL, Sugiyama K, Ohnuki T, Hattori K, Watanabe K, Nagatomo T: Comparison of binding affinities of omega-conotoxin and amlodipine to N-type Ca2+ channels in rat brain. Zhongguo Yao Li Xue Bao. 1998 Mar;19(2):97-100. - Pubmed
DTHybrid score	0.3145
Voltage-gated calcium channel beta 1 subunit splice variant CavB1d
Name	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d
Gene Name	CACNB1
Pharmacological action	unknown
Actions	inhibitor
References	Furukawa T, Nukada T, Suzuki K, Fujita Y, Mori Y, Nishimura M, Yamanaka M: Voltage and pH dependent block of cloned N-type Ca2+ channels by amlodipine. Br J Pharmacol. 1997 Jul;121(6):1136-40. - Pubmed Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T: Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73. - Pubmed Miyashita Y, Furukawa T, Kamegaya E, Yoshii M, Nukada T: A region of N-type Ca(2+) channel critical for blockade by the dihydropyridine amlodipine. Eur J Pharmacol. 2010 Apr 25;632(1-3):14-22. Epub 2010 Jan 22. - Pubmed Murakami M, Nakagawasai O, Fujii S, Kameyama K, Murakami S, Hozumi S, Esashi A, Taniguchi R, Yanagisawa T, Tan-no K, Tadano T, Kitamura K, Kisara K: Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice. Eur J Pharmacol. 2001 May 11;419(2-3):175-81. - Pubmed Ogihara T, Kano T, Kakinuma C: Evaluation of the inhibitory effect of dihydropyridines on N-type calcium channel by virtual three-dimensional pharmacophore modeling. Arzneimittelforschung. 2009;59(6):283-8. - Pubmed Qu YL, Sugiyama K, Ohnuki T, Hattori K, Watanabe K, Nagatomo T: Comparison of binding affinities of omega-conotoxin and amlodipine to N-type Ca2+ channels in rat brain. Zhongguo Yao Li Xue Bao. 1998 Mar;19(2):97-100. - Pubmed
DTHybrid score	0.2179
Carbonic anhydrase 1
Name	Carbonic anhydrase 1
Gene Name	CA1
Pharmacological action	unknown
Actions	inhibitor
References	Puscas I, Gilau L, Coltau M, Pasca R, Domuta G, Baican M, Hecht A: Hypotensive effect of calcium channel blockers is parallel with carbonic anhydrase I inhibition. Clin Pharmacol Ther. 2000 Oct;68(4):443-9. - Pubmed Puscas L, Gilau L, Coltau M, Pasca R, Domuta G, Baican M, Hecht A: Calcium channel blockers reduce blood pressure in part by inhibiting vascular smooth muscle carbonic anhydrase I. Cardiovasc Drugs Ther. 2000 Oct;14(5):523-8. - Pubmed Puscas I, Coltau M, Baican M, Pasca R, Domuta G, Hecht A: Vasoconstrictive drugs increase carbonic anhydrase I in vascular smooth muscle while vasodilating drugs reduce the activity of this isozyme by a direct mechanism of action. Drugs Exp Clin Res. 2001;27(2):53-60. - Pubmed
DTHybrid score	0.4551

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Katoh M, Nakajima M, Shimada N, Yamazaki H, Yokoi T: Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.1409
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.6713
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.5382
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Katoh M, Nakajima M, Shimada N, Yamazaki H, Yokoi T: Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7482
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inhibitor
References	Katoh M, Nakajima M, Shimada N, Yamazaki H, Yokoi T: Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4341
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inhibitor
References	Katoh M, Nakajima M, Shimada N, Yamazaki H, Yokoi T: Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5128
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5047
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5958
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7671
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7713

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Katoh M, Nakajima M, Yamazaki H, Yokoi T: Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4. Pharm Res. 2000 Oct;17(10):1189-97. - Pubmed
DTHybrid score	0.7161

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.517
6013	Cytochrome P450 2E1	CYP2E1	0.337
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.2185
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.217
357	Carbonic anhydrase 2	CA2	0.198
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.18
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.1573
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1556
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1555
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.1485
587	Serum albumin	ALB	0.1429
592	Carbonic anhydrase 4	CA4	0.1425
20	Prostaglandin G/H synthase 1	PTGS1	0.1278
6106	Cytochrome P450 2C18	CYP2C18	0.1138
492	Histamine H1 receptor	HRH1	0.1133
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1074
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.1049
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.1046
1729	Solute carrier family 22 member 6	SLC22A6	0.1031
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0976
465	Calmodulin	CALM1	0.0974
6145	Solute carrier family 22 member 1	SLC22A1	0.097
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0968
824	Sodium-dependent serotonin transporter	SLC6A4	0.0956
862	Multidrug resistance-associated protein 1	ABCC1	0.0949
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0878
1898	Cytochrome P450 1B1	CYP1B1	0.0872
556	Alpha-1A adrenergic receptor	ADRA1A	0.0859
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0827
831	D(2) dopamine receptor	DRD2	0.0824
6144	Solute carrier family 22 member 2	SLC22A2	0.0794
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0791
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0787
3811	Cytochrome P450 19A1	CYP19A1	0.0764
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0762
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0739
16	Adenosine A1 receptor	ADORA1	0.0732
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0731
776	Bile salt export pump	ABCB11	0.0729
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0709
737	Mineralocorticoid receptor	NR3C2	0.0708
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0691
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0681
318	Alpha-2A adrenergic receptor	ADRA2A	0.0645
466	Solute carrier family 12 member 3	SLC12A3	0.0643
632	Alpha-1B adrenergic receptor	ADRA1B	0.0633
4604	Liver carboxylesterase 1	CES1	0.0631
290	Prostaglandin G/H synthase 2	PTGS2	0.0627
118	Organic cation/carnitine transporter 2	SLC22A5	0.0621
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0613
847	Mu-type opioid receptor	OPRM1	0.0606
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0605
193	Beta-1 adrenergic receptor	ADRB1	0.0595
6147	Solute carrier family 22 member 3	SLC22A3	0.0588
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0581
766	Beta-2 adrenergic receptor	ADRB2	0.0578
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0574
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0566
378	Alpha-2C adrenergic receptor	ADRA2C	0.0563
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0561
6220	Aryl hydrocarbon receptor	AHR	0.0558
136	Estrogen receptor	ESR1	0.0551
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0547
871	Glucocorticoid receptor	NR3C1	0.0546
6048	Troponin C, skeletal muscle	TNNC2	0.0543
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0542
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0534
789	Alpha-1D adrenergic receptor	ADRA1D	0.0508
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0506
6126	Carbonic anhydrase 7	CA7	0.0506
2164	Multidrug resistance-associated protein 4	ABCC4	0.0498
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0497
713	Sodium-dependent dopamine transporter	SLC6A3	0.0489
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.048
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0475
6031	Cytochrome P450 3A43	CYP3A43	0.0474
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0471
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0468
468	Cytochrome P450 4A11	CYP4A11	0.0468
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0467
467	Delta-type opioid receptor	OPRD1	0.0462
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0459
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0454
558	Solute carrier family 12 member 1	SLC12A1	0.0453
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0445
3923	Cholinesterase	BCHE	0.0439
696	Kappa-type opioid receptor	OPRK1	0.0434
833	Organic cation/carnitine transporter 1	SLC22A4	0.0426
23	D(1A) dopamine receptor	DRD1	0.0423
731	HIV-1 protease	HIV-1 protease	0.0418
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0416
6143	Solute carrier family 22 member 7	SLC22A7	0.0415
3941	Amine oxidase [flavin-containing] A	MAOA	0.0412
6142	Solute carrier family 22 member 8	SLC22A8	0.0407
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0403
629	Alpha-2B adrenergic receptor	ADRA2B	0.0394
6148	Multidrug resistance-associated protein 7	ABCC10	0.0393
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0387
817	DNA topoisomerase 2-alpha	TOP2A	0.0382
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0376
260	Cytochrome P450 51	ERG11	0.0369
761	Cytochrome P450 51	ERG11	0.0369
3163	Cytochrome P450 51	cyp51	0.0369
6070	Nischarin	NISCH	0.0361
3007	Carbonic anhydrase 12	CA12	0.036
638	D(3) dopamine receptor	DRD3	0.036
4205	Carbonic anhydrase 9	CA9	0.036
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0356
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0341
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0339
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0339
6182	Cytochrome P450 2J2	CYP2J2	0.0329
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0324
3939	Amine oxidase [flavin-containing] B	MAOB	0.0319
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0318
6014	Cytochrome P450 2A13	CYP2A13	0.0313
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0307
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0304
122	P2Y purinoceptor 12	P2RY12	0.0287
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0287
751	Potassium channel subfamily K member 6	KCNK6	0.0286
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0285
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0282
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0278
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0275
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0275
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0275
477	DNA topoisomerase 4 subunit A	parC	0.0272
886	DNA topoisomerase 4 subunit A	parC	0.0272
6226	DNA topoisomerase 4 subunit A	parC	0.0272
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0271
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0271
404	DNA gyrase subunit A	gyrA	0.0268
6224	DNA gyrase subunit A	gyrA	0.0268
614	Progesterone receptor	PGR	0.0266
844	Epidermal growth factor receptor	EGFR	0.0265
172	Potassium channel subfamily K member 1	KCNK1	0.0261
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.026
36	Insulin receptor	INSR	0.0258
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0252
504	Mast/stem cell growth factor receptor	KIT	0.0246
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0245
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0245
233	Potassium channel subfamily K member 2	KCNK2	0.0242
777	Tumor necrosis factor	TNF	0.0241
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0237
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0237
891	Dihydropteroate synthase	folP	0.0234
5359	Dihydropteroate synthase	folP	0.0234
7175	Dihydropteroate synthase	sulI	0.0234
146	Androgen receptor	AR	0.0234
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0234
1024	Solute carrier family 22 member 11	SLC22A11	0.0231
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0231
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0228
6136	Multidrug resistance-associated protein 5	ABCC5	0.0225
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0225
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0225
380	Cytochrome P450 17A1	CYP17A1	0.0222
811	Translocator protein	TSPO	0.0221
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0221
432	D(4) dopamine receptor	DRD4	0.0219
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0216
1108	Calpastatin	CAST	0.0211
1089	Cartilage oligomeric matrix protein	COMP	0.0211
4120	NADPH--cytochrome P450 reductase	POR	0.021
756	Sex hormone-binding globulin	SHBG	0.021
1010	Cytochrome P450 51A1	CYP51A1	0.0207
6102	Arylamine N-acetyltransferase 2	NAT2	0.0207
1405	Thiopurine S-methyltransferase	TPMT	0.0206
869	Estrogen receptor beta	ESR2	0.0206
232	Corticosteroid-binding globulin	SERPINA6	0.0198
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0196
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0196
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0191
6141	Sodium/bile acid cotransporter	SLC10A1	0.0191
6137	Multidrug resistance-associated protein 6	ABCC6	0.0191
94	5-hydroxytryptamine 4 receptor	HTR4	0.0191
716	5-hydroxytryptamine 7 receptor	HTR7	0.019
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0188
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0186
70	Type-1 angiotensin II receptor	AGTR1	0.0185
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0185
818	50S ribosomal protein L10	rplJ	0.0184
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0183
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0183
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0182
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0181
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0179
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0179
407	Vascular endothelial growth factor receptor 2	KDR	0.0176
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0176
26	Vascular endothelial growth factor receptor 3	FLT4	0.0173
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0173
6131	Carbonic anhydrase 14	CA14	0.0169
1192	Sulfotransferase 1A1	SULT1A1	0.0168
29	Tubulin beta-1 chain	TUBB1	0.0167
6020	Aldehyde oxidase	AOX1	0.0166
32	Vascular endothelial growth factor receptor 1	FLT1	0.0165
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0165
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0164
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0164
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0164
705	Glutamate receptor 1	GRIA1	0.0163
124	Histamine H2 receptor	HRH2	0.0163
482	Glycine receptor subunit alpha-1	GLRA1	0.0162
1178	Adenosine A2a receptor	ADORA2A	0.0161
6122	Carbonic anhydrase 3	CA3	0.0161
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0161
1757	Myeloperoxidase	MPO	0.016
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.016
4237	50S ribosomal protein L22	rplV	0.016
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0159
3932	Glutathione S-transferase A2	GSTA2	0.0158
1656	CYP2B protein	CYP2B	0.0158
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0156
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0156
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0155
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0154
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0154
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0154
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0154
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0154
4238	50S ribosomal protein L4	rplD	0.0153
5578	50S ribosomal protein L4	rplD	0.0153
6173	50S ribosomal protein L4	rplD	0.0153
6219	50S ribosomal protein L4	rplD	0.0153
952	Dipeptidyl peptidase 4	DPP4	0.0153
474	Acetylcholinesterase	ACHE	0.0153
427	Substance-P receptor	TACR1	0.0152
161	Tubulin beta chain	TUBB	0.0152
312	Tubulin beta chain	TUB2	0.0152
3947	Xanthine dehydrogenase/oxidase	XDH	0.0152
1517	Beta-3 adrenergic receptor	ADRB3	0.0149
2449	Tubulin alpha-3 chain	TUBA1A	0.0148
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0147
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0146
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0146
2499	Tubulin beta-2C chain	TUBB2C	0.0144
310	Solute carrier family 12 member 2	SLC12A2	0.0143
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0138
373	Transthyretin	TTR	0.0138
131	Synaptic vesicular amine transporter	SLC18A2	0.0136
174	Sigma 1-type opioid receptor	SIGMAR1	0.0135
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0133
163	D(1B) dopamine receptor	DRD5	0.0133
84	Nuclear receptor 0B1	NR0B1	0.0132
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.013
4203	Histamine N-methyltransferase	HNMT	0.013
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0129
275	Arachidonate 5-lipoxygenase	ALOX5	0.0128
2112	Toll-like receptor 9	TLR9	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
2132	Protein S100-B	S100B	0.0126
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0124
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0123
613	Atrial natriuretic peptide receptor A	NPR1	0.0122
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0122
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0122
3426	Glutamine synthetase	glnA	0.0122
3987	Glutamine synthetase	GLUL	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.012
365	Dihydrofolate reductase	DHFR	0.0118
2381	Dihydrofolate reductase	DFR1	0.0118
2833	Dihydrofolate reductase	Not Available	0.0118
2931	Dihydrofolate reductase	folA	0.0118
3544	Dihydrofolate reductase	folA	0.0118
3682	Dihydrofolate reductase	folA	0.0118
6642	Dihydrofolate reductase	folA	0.0118
6756	Dihydrofolate reductase	dfrA	0.0118
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0117
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0117
1050	Bile salt sulfotransferase	SULT2A1	0.0116
48	Pyridoxal kinase	PDXK	0.0116
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0116
738	Monocarboxylate transporter 1	SLC16A1	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0114
88	Retinoic acid receptor RXR-beta	RXRB	0.0114
6085	Fatty acid-binding protein, intestinal	FABP2	0.0112
4122	Histone deacetylase 2	HDAC2	0.0111
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0111
921	Glutamate receptor 2	GRIA2	0.0111
273	Apoptosis regulator Bcl-2	BCL2	0.011
68	Cannabinoid receptor 1	CNR1	0.0109
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
469	Annexin A1	ANXA1	0.0108
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0108
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0108
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0108
1025	Aquaporin-1	AQP1	0.0106
814	Ryanodine receptor 1	RYR1	0.0106
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0106
571	Melatonin receptor type 1A	MTNR1A	0.0104
362	Melatonin receptor type 1B	MTNR1B	0.0104
165	FL cytokine receptor	FLT3	0.0103
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0103
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0102
780	Retinoic acid receptor RXR-gamma	RXRG	0.0102
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
1629	Transcription factor AP-1	JUN	0.0101
239	Coagulation factor X	F10	0.0101
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0101
823	Fibroblast growth factor receptor 2	FGFR2	0.01
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.01
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0098
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0097
4116	Dihydropteroate synthetase	Not Available	0.0097
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
3810	Catechol O-methyltransferase	COMT	0.0093
634	Squalene monooxygenase	SQLE	0.0092
7196	Squalene monooxygenase	ERG1	0.0092
4311	tRNA	TRDMT1	0.0092
4325	tRNA	trmD	0.0092
4328	tRNA	trmD	0.0092
319	Opioid receptor, sigma 1	OPRS1	0.0092
24	Thymidylate synthase	TMP1	0.0091
359	Thymidylate synthase	TYMS	0.0091
2626	Thymidylate synthase	thyA	0.0091
2729	Thymidylate synthase	thyA	0.0091
5352	Thymidylate synthase	THYA	0.0091
1852	Microtubule-associated protein 2	MAP2	0.0091
2539	Tubulin alpha-1 chain	TUBA4A	0.009
4228	Keratin, type II cytoskeletal 7	KRT7	0.009
1353	DNA topoisomerase 1	TOP1	0.0089
3552	DNA topoisomerase 1	topA	0.0089
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0089
33	Cystine/glutamate transporter	SLC7A11	0.0089
518	Peroxidase/catalase T	katG	0.0089
6174	50S ribosomal protein L32	rpmF	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
284	DNA-directed RNA polymerase beta chain	rpoB	0.0088
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0088
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0088
251	Alcohol dehydrogenase 1A	ADH1A	0.0088
54	Prothrombin	F2	0.0088
162	Retinoic acid receptor gamma-1	RARG	0.0088
3809	Estrogen-related receptor gamma	ESRRG	0.0088
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0088
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0088
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
723	Cytosolic phospholipase A2	PLA2G4A	0.0087
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0087
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0087
5934	Cytochrome P450 26A1	CYP26A1	0.0087
6138	Multidrug resistance protein 3	ABCB4	0.0086
1275	Estrogen sulfotransferase	SULT1E1	0.0085
1618	High affinity nerve growth factor receptor	NTRK1	0.0085
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0085
106	Cannabinoid receptor 2	CNR2	0.0085
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0084
563	Thyroid peroxidase	TPO	0.0084
790	DNA polymerase subunit alpha B	POLA2	0.0084
976	Platelet glycoprotein IX	GP9	0.0082
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0082
444	Alcohol dehydrogenase 1B	ADH1B	0.0082
569	Retinal dehydrogenase 2	ALDH1A2	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
719	Retinoic acid receptor responder protein 1	RARRES1	0.008
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.008
770	Retinoic acid-induced protein 3	GPRC5A	0.008
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.008
6146	High affinity copper uptake protein 1	SLC31A1	0.008
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0079
173	Toll-like receptor 7	TLR7	0.0079
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0078
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0078
856	Vitamin D3 receptor	VDR	0.0077
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
611	Retinal dehydrogenase 1	ALDH1A1	0.0076
244	Angiotensin-converting enzyme	ACE	0.0076
820	Glycine receptor subunit alpha-2	GLRA2	0.0076
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0076
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0076
5300	Antigen peptide transporter 1	TAP1	0.0075
581	Cytochrome P450 2R1	CYP2R1	0.0075
6044	Serum paraoxonase/lactonase 3	PON3	0.0075
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0075
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0075
6432	Transporter	snf	0.0075
4103	Proteasome subunit beta type 2	PSMB2	0.0074
4102	Proteasome subunit beta type 5	PSMB5	0.0074
4101	Proteasome subunit beta type 1	PSMB1	0.0074
1541	Metalloproteinase	mmp20	0.0074
6766	O-GlcNAcase BT_4395	BT_4395	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
7	Nitric oxide synthase, inducible	NOS2	0.0073
6043	Putative G-protein coupled receptor 44	GPR44	0.0072
904	Glutathione S-transferase P	GSTP1	0.0072
5923	Microtubule-associated protein tau	MAPT	0.0071
5924	Microtubule-associated protein 4	MAP4	0.0071
2230	Catalase	CAT	0.0071
3249	Catalase	katA	0.0071
3625	Catalase	katA	0.0071
4539	Catalase	katA	0.0071
4941	Catalase	katB	0.0071
1630	Integrin beta-2	ITGB2	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
517	Alcohol dehydrogenase 1C	ADH1C	0.007
49	Endothelin B receptor	EDNRB	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
3086	Plasmepsin-2	Not Available	0.0068
1636	Trace amine-associated receptor 1	TAAR1	0.0067
1196	Complement decay-accelerating factor	CD55	0.0067
3856	Fibroblast growth factor receptor 3	FGFR3	0.0066
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0065
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
2236	Casein kinase II subunit alpha	CSNK2A1	0.0064
1714	Mitogen-activated protein kinase 3	MAPK3	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0063
1648	Elastin	ELN	0.0063
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
4773	Deoxycytidine kinase	DCK	0.0062
183	Vascular endothelial growth factor A	VEGFA	0.0062
1992	Vitamin D-binding protein	GC	0.0061
153	Dopamine beta-hydroxylase	DBH	0.0061
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0061
936	Ephrin type-A receptor 2	EPHA2	0.006
4192	DNA topoisomerase 2-beta	TOP2B	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
1483	Membrane copper amine oxidase	AOC3	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
2808	Chloramphenicol acetyltransferase 3	cat3	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0058
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0058
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0057
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0057
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0057
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0057
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0057
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0057
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0057
3957	Adenosine deaminase	ADA	0.0056
908	Glutathione S-transferase theta-1	GSTT1	0.0055
3937	Fatty-acid amide hydrolase	FAAH	0.0055
267	Plasminogen activator inhibitor 1	SERPINE1	0.0055
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0055
6506	Stathmin-4	STMN4	0.0055
461	Glycine receptor subunit alpha-3	GLRA3	0.0055
5787	Angiopoietin-1 receptor	TEK	0.0054
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0053
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0053
3601	Dihydropteroate synthase 1	folP1	0.0053
3807	Dihydropteroate synthase 1	folP1	0.0053
3808	Dihydropteroate synthase 2	folP2	0.0053
2417	Chloramphenicol acetyltransferase	cat	0.0053
3278	Chloramphenicol acetyltransferase	cat	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0052
164	Histamine H4 receptor	HRH4	0.0052
2810	Dr hemagglutinin structural subunit	draA	0.0052
1262	Corticotropin-lipotropin	POMC	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0052
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0052
712	Tubulin alpha chain	TUB1	0.0052
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0052
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
2408	Tyrosine-protein kinase SYK	SYK	0.005
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0049
6221	Steroid hormone receptor ERR1	ESRRA	0.0049
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0049
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
1374	Natriuretic peptides B	NPPB	0.0048
1827	Gap junction alpha-1 protein	GJA1	0.0048
1908	Vascular cell adhesion protein 1	VCAM1	0.0048
997	Protein kinase C beta type	PRKCB	0.0048
1176	Mitogen-activated protein kinase 1	MAPK1	0.0047
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
1039	Histone deacetylase 9	HDAC9	0.0046
4217	Telomerase reverse transcriptase	TERT	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6824	Tyrosine-protein kinase Lyn	LYN	0.0045
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0044
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0044
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0044
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0044
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0044
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0044
400	Coagulation factor IX	F9	0.0044
5461	Coagulation factor IX	F9	0.0044
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0044
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0044
1970	Protein kinase C alpha type	PRKCA	0.0044
3639	Thymidine phosphorylase	deoA	0.0044
3936	Thymidine phosphorylase	TYMP	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0044
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0044
572	Integrin alpha-L	ITGAL	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0043
268	Adenosine A2b receptor	ADORA2B	0.0043
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0043
4226	Uridine phosphorylase 2	UPP2	0.0043
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0042
3913	Glutamic acid decarboxylase	GAD65	0.0042
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0042
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0042
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
2298	Cytochrome P450-cam	camC	0.0041
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0041
604	Vitamin K-dependent protein Z	PROZ	0.0041
1864	RET proto-oncogene	RET	0.0041
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.004
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.004
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.004
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.004
730	Retinoic acid receptor alpha	RARA	0.004
6149	Solute carrier family 22 member 10	SLC22A10	0.004
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0039
4225	Uridine phosphorylase 1	UPP1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
484	Tyrosine-protein kinase ABL2	ABL2	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
1569	G1/S-specific cyclin-D1	CCND1	0.0038
594	Thyroxine-binding globulin	SERPINA7	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
422	Vitamin K-dependent protein C	PROC	0.0037
1245	Vitamin K-dependent protein S	PROS1	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
413	Amidophosphoribosyltransferase	PPAT	0.0037
2515	Amidophosphoribosyltransferase	purF	0.0037
3714	Amidophosphoribosyltransferase	purF	0.0037
2207	Rhodopsin	RHO	0.0036
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0036
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
2216	Fibroblast growth factor receptor 4	FGFR4	0.0035
2320	Thymidine kinase, cytosolic	TK1	0.0035
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0035
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0035
3904	Alanine aminotransferase 2	GPT2	0.0035
735	Alanine aminotransferase 1	GPT	0.0035
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0035
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0035
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0035
1268	Neuropeptide S receptor	NPSR1	0.0035
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0035
896	Glutathione S-transferase Mu 1	GSTM1	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
291	Nitric-oxide synthase, endothelial	NOS3	0.0035
758	Thyroid hormone receptor alpha	THRA	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3830	Calreticulin	CALR	0.0034
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0034
6163	Copper-transporting ATPase 2	ATP7B	0.0034
6165	Copper-transporting ATPase 1	ATP7A	0.0034
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0033
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0033
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0033
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
6034	Hydroxyindole O-methyltransferase	ASMT	0.0032
6035	Nuclear receptor ROR-beta	RORB	0.0032
6036	Eosinophil peroxidase	EPX	0.0032
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
6073	Potassium channel subfamily K member 9	KCNK9	0.0032
6072	Potassium channel subfamily K member 3	KCNK3	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
5798	Mitogen-activated protein kinase 11	MAPK11	0.0031
346	Thyroid hormone receptor beta-1	THRB	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
798	Osteocalcin	BGLAP	0.003
2599	Tyrosine-protein kinase HCK	HCK	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
6127	Carbonic anhydrase-related protein	CA8	0.0029
6129	Carbonic anhydrase-related protein 11	CA11	0.0029
6133	Sodium channel subunit beta-2	SCN2B	0.0029
6128	Carbonic anhydrase-related protein 10	CA10	0.0029
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0029
6134	Sodium channel subunit beta-3	SCN3B	0.0029
6132	Sodium channel subunit beta-1	SCN1B	0.0029
6135	Sodium channel subunit beta-4	SCN4B	0.0029
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1291	cAMP response element-binding protein	CREB1	0.0028
765	Indoleamine 2,3-dioxygenase	IDO1	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
199	Monocarboxylate transporter 8	SLC16A2	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
6130	Carbonic anhydrase 13	CA13	0.0027
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0027
4210	Toll-like receptor 4	TLR4	0.0027
369	Coagulation factor VII	F7	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0026
6859	Protein S100-A4	S100A4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
760	Fibroblast growth factor 1	FGF1	0.0024
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
822	Aldose reductase	AKR1B1	0.0023
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0023
707	72 kDa type IV collagenase	MMP2	0.0022
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2300	Lysozyme	E	0.0021
3633	Lysozyme	R	0.0021
5597	Lysozyme	17	0.0021
489	Monocarboxylate transporter 2	SLC16A7	0.0021
2091	Endoplasmin	HSP90B1	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
6459	Glycodelin	PAEP	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
65	Matrix metalloproteinase-9	Not Available	0.0019
2021	Thrombomodulin	THBD	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
6218	Pannexin-1	PANX1	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
6151	Monocarboxylate transporter 10	SLC16A10	0.0017
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0017
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0017
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0017
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0017
6168	Solute carrier family 22 member 16	SLC22A16	0.0017
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0016
6837	Serine/threonine-protein kinase 17B	STK17B	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0016
1243	Cathepsin D	CTSD	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
1650	Heme carrier protein 1	SLC46A1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0014
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0014
76	Nitric-oxide synthase, brain	NOS1	0.0014
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
3221	Cytochrome c4	cc4	0.0014
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0014
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
1792	Tissue-type plasminogen activator	PLAT	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
1295	Fatty acid synthase	FASN	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0012
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0012
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4984	Neuroglobin	NGB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
5000	HemO	hemO	0.0008
4910	Cytoglobin	CYGB	0.0008
4909	CooA protein	cooA	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4972	P450cin	cinA	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
3093	Catalase HPII	katE	0.0008
4952	Catalase/peroxidase	katA	0.0008
1867	Major prion protein	PRNP	0.0008
1507	Cytochrome c	CYCS	0.0008
6042	Prostaglandin reductase 2	PTGR2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
125	DNA polymerase beta	POLB	0.0007
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
1313	Lactoylglutathione lyase	GLO1	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00381 - Amlodipine

Targets

Enzymes

Transporters

Predictions