DT-Web: DB00278

Identification

Name

Argatroban

Accession Number

DB00278 (APRD00105)

Type

small molecule

Description

Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT and prevent the formation of thrombi. Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be obtained prior to administering argatroban.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

508.634

Groups

approved

Monoisotopic Weight

508.246788982

Pharmacology

Indication

Argatroban is indicated for prevention and treatment of thrombosis caused by heparin induced thrombocytopenia (HIT). It is also indicated for use in patients with, or at risk for, HIT who are undergoing percutaneous coronary intervention.

Mechanism of action

Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; protein C; and platelet aggregation.

Absorption

Bioavailability is 100% (intravenous).

Protein binding

54%

Biotransformation

Liver via hydroxylation and aromatization of the 3-methyltetrahydroquinoline ring. Age and gender do not substantially affect the pharmacodynamic or pharmacokinetic profile of argatroban.

Route of elimination

Argatroban is excreted primarily in the feces (65%), presumably through biliary secretion; 22% is eliminated via urine.

Toxicity

Excessive bleeding

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Treprostinil	The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the anticoagulant, Argatroban. Monitor for increased bleeding during concomitant thearpy.

Food Interactions

Herbs and food with anticoagulant/antiplatelet activity. Major interactions may occur with danshen, dong quai, evening primrose oil, gingko, policosanol, willow bark

Prothrombin
Name	Prothrombin
Gene Name	F2
Pharmacological action	yes
Actions	inhibitor
References	Kawada T, Okada Y, Hoson M, Endo S, Yokoyama M, Kitanaka Y, Kimura K, Abe H, Yamate N: Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture. Jpn J Thorac Cardiovasc Surg. 1999 Mar;47(3):104-9. - Pubmed Sakai M, Ohteki H, Narita Y, Naitoh K, Natsuaki M, Itoh T: Argatroban as a potential anticoagulant in cardiopulmonary bypass-studies in a dog model. Cardiovasc Surg. 1999 Mar;7(2):187-94. - Pubmed Jang IK, Brown DF, Giugliano RP, Anderson HV, Losordo D, Nicolau JC, Dutra OP, Bazzino O, Viamonte VM, Norbady R, Liprandi AS, Massey TJ, Dinsmore R, Schwarz RP Jr: A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study. J Am Coll Cardiol. 1999 Jun;33(7):1879-85. - Pubmed Matsuo T, Kario K, Matsuda S, Yamaguchi N, Kakishita E: Effect of Thrombin Inhibition on Patients with Peripheral Arterial Obstructive Disease: A Multicenter Clinical Trial of Argatroban. J Thromb Thrombolysis. 1995;2(2):131-136. - Pubmed Serebruany VL, Jang IK, Giugliano RP, Massey TJ, Schwarz Jr RP: A Randomized, Blinded Study of Two Doses of Novastan(R) (Brand of Argatroban) Versus Heparin as Adjunctive Therapy to Recombinant Tissue Plasminogen Activator (Accelerated Administration) in Acute Myocardial Infarction: Rationale and Design of the Myocardial Infarction using Novastan(R) and T-PA (MINT) Study. J Thromb Thrombolysis. 1998;5(1):49-52. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.5705

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3406
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2011

Id	Partner name	Gene Name	Score
6107	Cytochrome P450 3A7	CYP3A7	0.1143
3176	Trypsin-1	PRSS1	0.1044
1588	Multidrug resistance protein 1	ABCB1	0.1022
4119	Cytochrome P450 2D6	CYP2D6	0.0989
4757	Cytochrome P450 2C9	CYP2C9	0.0859
6016	Cytochrome P450 2C19	CYP2C19	0.0806
4200	Cytochrome P450 1A2	CYP1A2	0.0718
4924	Cytochrome P450 2C8	CYP2C8	0.0673
6030	Cytochrome P450 2B6	CYP2B6	0.0487
239	Coagulation factor X	F10	0.0434
6013	Cytochrome P450 2E1	CYP2E1	0.0394
1074	Urokinase-type plasminogen activator	PLAU	0.0362
6024	Cytochrome P450 1A1	CYP1A1	0.0341
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0285
587	Serum albumin	ALB	0.0278
5718	Cytochrome P450 2A6	CYP2A6	0.0246
871	Glucocorticoid receptor	NR3C1	0.0224
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0206
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.02
862	Multidrug resistance-associated protein 1	ABCC1	0.0198
1181	Alpha-1-acid glycoprotein 1	ORM1	0.019
492	Histamine H1 receptor	HRH1	0.0186
369	Coagulation factor VII	F7	0.0173
20	Prostaglandin G/H synthase 1	PTGS1	0.017
3119	Fimbrial protein	pilE1	0.0168
3811	Cytochrome P450 19A1	CYP19A1	0.0167
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0163
847	Mu-type opioid receptor	OPRM1	0.0162
6031	Cytochrome P450 3A43	CYP3A43	0.015
6106	Cytochrome P450 2C18	CYP2C18	0.0145
824	Sodium-dependent serotonin transporter	SLC6A4	0.0144
6145	Solute carrier family 22 member 1	SLC22A1	0.0144
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0143
776	Bile salt export pump	ABCB11	0.0138
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0136
1898	Cytochrome P450 1B1	CYP1B1	0.0135
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0132
556	Alpha-1A adrenergic receptor	ADRA1A	0.0132
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0132
731	HIV-1 protease	HIV-1 protease	0.0128
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0128
831	D(2) dopamine receptor	DRD2	0.0127
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0127
232	Corticosteroid-binding globulin	SERPINA6	0.0127
6564	Prephenate dehydrogenase	tyrA	0.0122
6240	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	PIN1	0.0122
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0121
467	Delta-type opioid receptor	OPRD1	0.012
1729	Solute carrier family 22 member 6	SLC22A6	0.0118
318	Alpha-2A adrenergic receptor	ADRA2A	0.0118
136	Estrogen receptor	ESR1	0.0117
6144	Solute carrier family 22 member 2	SLC22A2	0.0116
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0114
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0107
614	Progesterone receptor	PGR	0.0105
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0104
260	Cytochrome P450 51	ERG11	0.0101
761	Cytochrome P450 51	ERG11	0.0101
3163	Cytochrome P450 51	cyp51	0.0101
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0101
6182	Cytochrome P450 2J2	CYP2J2	0.0101
2331	HTH-type transcriptional regulator qacR	qacR	0.01
6461	HTH-type transcriptional regulator qacR	qacR	0.01
696	Kappa-type opioid receptor	OPRK1	0.01
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0099
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0099
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
1757	Myeloperoxidase	MPO	0.0096
632	Alpha-1B adrenergic receptor	ADRA1B	0.0096
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0095
6828	TetR family transcriptional repressor LfrR	lfrR	0.0095
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
256	Tyrosyl-tRNA synthetase, cytoplasmic	YARS	0.0093
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0093
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0093
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0093
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0092
3384	Macrophage migration inhibitory factor	MIF	0.009
638	D(3) dopamine receptor	DRD3	0.0089
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0088
6143	Solute carrier family 22 member 7	SLC22A7	0.0087
6142	Solute carrier family 22 member 8	SLC22A8	0.0085
290	Prostaglandin G/H synthase 2	PTGS2	0.0085
23	D(1A) dopamine receptor	DRD1	0.0085
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0085
817	DNA topoisomerase 2-alpha	TOP2A	0.0084
19	Coagulation factor VIII	F8	0.0083
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
4604	Liver carboxylesterase 1	CES1	0.0081
723	Cytosolic phospholipase A2	PLA2G4A	0.008
798	Osteocalcin	BGLAP	0.008
713	Sodium-dependent dopamine transporter	SLC6A3	0.0079
737	Mineralocorticoid receptor	NR3C2	0.0079
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0077
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0076
6148	Multidrug resistance-associated protein 7	ABCC10	0.0076
118	Organic cation/carnitine transporter 2	SLC22A5	0.0075
3831	Low-density lipoprotein receptor-related protein 1	LRP1	0.0075
378	Alpha-2C adrenergic receptor	ADRA2C	0.0074
818	50S ribosomal protein L10	rplJ	0.0074
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0072
629	Alpha-2B adrenergic receptor	ADRA2B	0.0072
3851	Serine protease hepsin	HPN	0.0071
766	Beta-2 adrenergic receptor	ADRB2	0.0071
814	Ryanodine receptor 1	RYR1	0.0071
468	Cytochrome P450 4A11	CYP4A11	0.0071
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.007
844	Epidermal growth factor receptor	EGFR	0.0068
29	Tubulin beta-1 chain	TUBB1	0.0068
2164	Multidrug resistance-associated protein 4	ABCC4	0.0067
705	Glutamate receptor 1	GRIA1	0.0067
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0067
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0066
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0066
811	Translocator protein	TSPO	0.0065
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0065
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0064
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0064
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0064
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0064
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0063
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0063
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0063
6147	Solute carrier family 22 member 3	SLC22A3	0.0062
789	Alpha-1D adrenergic receptor	ADRA1D	0.0061
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0061
725	5-hydroxytryptamine 1D receptor	HTR1D	0.006
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.006
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.006
6020	Aldehyde oxidase	AOX1	0.006
274	Muscarinic acetylcholine receptor M5	CHRM5	0.006
756	Sex hormone-binding globulin	SHBG	0.006
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.006
952	Dipeptidyl peptidase 4	DPP4	0.0058
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0058
432	D(4) dopamine receptor	DRD4	0.0057
6220	Aryl hydrocarbon receptor	AHR	0.0057
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0056
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0056
3923	Cholinesterase	BCHE	0.0056
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0056
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0056
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0055
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0055
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0055
146	Androgen receptor	AR	0.0055
407	Vascular endothelial growth factor receptor 2	KDR	0.0054
504	Mast/stem cell growth factor receptor	KIT	0.0053
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0053
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0053
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0051
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0051
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0051
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0051
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0051
833	Organic cation/carnitine transporter 1	SLC22A4	0.0051
777	Tumor necrosis factor	TNF	0.005
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.005
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.005
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.005
6137	Multidrug resistance-associated protein 6	ABCC6	0.005
768	FK506-binding protein 1A	FKBP1A	0.005
4237	50S ribosomal protein L22	rplV	0.0049
26	Vascular endothelial growth factor receptor 3	FLT4	0.0049
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0048
122	P2Y purinoceptor 12	P2RY12	0.0048
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0047
716	5-hydroxytryptamine 7 receptor	HTR7	0.0047
4165	P2Y purinoceptor 2	P2RY2	0.0047
32	Vascular endothelial growth factor receptor 1	FLT1	0.0047
193	Beta-1 adrenergic receptor	ADRB1	0.0046
2539	Tubulin alpha-1 chain	TUBA4A	0.0046
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0045
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0044
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0043
161	Tubulin beta chain	TUBB	0.0043
312	Tubulin beta chain	TUB2	0.0043
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0043
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0042
477	DNA topoisomerase 4 subunit A	parC	0.0042
886	DNA topoisomerase 4 subunit A	parC	0.0042
6226	DNA topoisomerase 4 subunit A	parC	0.0042
465	Calmodulin	CALM1	0.0042
404	DNA gyrase subunit A	gyrA	0.0042
6224	DNA gyrase subunit A	gyrA	0.0042
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0041
1656	CYP2B protein	CYP2B	0.0041
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0041
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.004
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.004
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0039
400	Coagulation factor IX	F9	0.0039
5461	Coagulation factor IX	F9	0.0039
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0039
3947	Xanthine dehydrogenase/oxidase	XDH	0.0039
1547	Coagulation factor XI	F11	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0038
2654	Complement control protein	C3L	0.0037
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0036
427	Substance-P receptor	TACR1	0.0036
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0036
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0036
1024	Solute carrier family 22 member 11	SLC22A11	0.0036
1959	Platelet factor 4	PF4	0.0035
3865	Serpin B6	SERPINB6	0.0035
1986	Ceruloplasmin	CP	0.0035
856	Vitamin D3 receptor	VDR	0.0035
5300	Antigen peptide transporter 1	TAP1	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
124	Histamine H2 receptor	HRH2	0.0035
1245	Vitamin K-dependent protein S	PROS1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
1483	Membrane copper amine oxidase	AOC3	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
430	Follicle-stimulating hormone receptor	FSHR	0.0034
284	DNA-directed RNA polymerase beta chain	rpoB	0.0034
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0034
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0034
1010	Cytochrome P450 51A1	CYP51A1	0.0034
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0034
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0034
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0034
4238	50S ribosomal protein L4	rplD	0.0033
5578	50S ribosomal protein L4	rplD	0.0033
6173	50S ribosomal protein L4	rplD	0.0033
6219	50S ribosomal protein L4	rplD	0.0033
267	Plasminogen activator inhibitor 1	SERPINE1	0.0033
474	Acetylcholinesterase	ACHE	0.0033
422	Vitamin K-dependent protein C	PROC	0.0033
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0033
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0033
3932	Glutathione S-transferase A2	GSTA2	0.0033
3842	Multiple coagulation factor deficiency protein 2	MCFD2	0.0033
3841	ERGIC-53 protein	LMAN1	0.0033
3840	Asialoglycoprotein receptor 2	ASGR2	0.0033
1847	78 kDa glucose-regulated protein	HSPA5	0.0033
1635	von Willebrand factor	VWF	0.0033
5455	Arylsulfatase A	ARSA	0.0032
1852	Microtubule-associated protein 2	MAP2	0.0032
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
165	FL cytokine receptor	FLT3	0.0032
3086	Plasmepsin-2	Not Available	0.0032
295	Carbonic anhydrase 1	CA1	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0031
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0031
153	Dopamine beta-hydroxylase	DBH	0.0031
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0031
163	D(1B) dopamine receptor	DRD5	0.0031
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0031
3833	Plasma serine protease inhibitor	SERPINA5	0.0031
2072	Endothelial protein C receptor	PROCR	0.0031
46	Coagulation factor V	F5	0.0031
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0031
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0031
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
3941	Amine oxidase [flavin-containing] A	MAOA	0.003
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.003
70	Type-1 angiotensin II receptor	AGTR1	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
869	Estrogen receptor beta	ESR2	0.003
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.003
6043	Putative G-protein coupled receptor 44	GPR44	0.003
6136	Multidrug resistance-associated protein 5	ABCC5	0.0029
94	5-hydroxytryptamine 4 receptor	HTR4	0.0029
1516	Calnexin	CANX	0.0028
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0028
6141	Sodium/bile acid cotransporter	SLC10A1	0.0027
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0027
6102	Arylamine N-acetyltransferase 2	NAT2	0.0027
2021	Thrombomodulin	THBD	0.0026
4203	Histamine N-methyltransferase	HNMT	0.0026
6014	Cytochrome P450 2A13	CYP2A13	0.0026
49	Endothelin B receptor	EDNRB	0.0026
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0025
380	Cytochrome P450 17A1	CYP17A1	0.0025
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0025
275	Arachidonate 5-lipoxygenase	ALOX5	0.0025
4120	NADPH--cytochrome P450 reductase	POR	0.0025
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0025
823	Fibroblast growth factor receptor 2	FGFR2	0.0025
2112	Toll-like receptor 9	TLR9	0.0025
469	Annexin A1	ANXA1	0.0024
5924	Microtubule-associated protein 4	MAP4	0.0024
5923	Microtubule-associated protein tau	MAPT	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
357	Carbonic anhydrase 2	CA2	0.0024
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0023
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0023
3830	Calreticulin	CALR	0.0023
131	Synaptic vesicular amine transporter	SLC18A2	0.0023
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0023
3839	Phytanoyl-CoA dioxygenase, peroxisomal	PHYH	0.0023
4311	tRNA	TRDMT1	0.0023
4325	tRNA	trmD	0.0023
4328	tRNA	trmD	0.0023
33	Cystine/glutamate transporter	SLC7A11	0.0023
6174	50S ribosomal protein L32	rpmF	0.0022
738	Monocarboxylate transporter 1	SLC16A1	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
273	Apoptosis regulator Bcl-2	BCL2	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
3939	Amine oxidase [flavin-containing] B	MAOB	0.0022
1196	Complement decay-accelerating factor	CD55	0.0022
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0021
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
1353	DNA topoisomerase 1	TOP1	0.0021
3552	DNA topoisomerase 1	topA	0.0021
4773	Deoxycytidine kinase	DCK	0.0021
4192	DNA topoisomerase 2-beta	TOP2B	0.0021
4122	Histone deacetylase 2	HDAC2	0.002
16	Adenosine A1 receptor	ADORA1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0019
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0019
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
1525	Heparin-binding growth factor 2	FGF2	0.0019
373	Transthyretin	TTR	0.0019
1178	Adenosine A2a receptor	ADORA2A	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
84	Nuclear receptor 0B1	NR0B1	0.0019
2808	Chloramphenicol acetyltransferase 3	cat3	0.0019
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0019
780	Retinoic acid receptor RXR-gamma	RXRG	0.0019
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0018
5787	Angiopoietin-1 receptor	TEK	0.0018
683	Potassium transporter	GK0582	0.0018
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0018
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
1517	Beta-3 adrenergic receptor	ADRB3	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
1618	High affinity nerve growth factor receptor	NTRK1	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
904	Glutathione S-transferase P	GSTP1	0.0017
6824	Tyrosine-protein kinase Lyn	LYN	0.0017
3601	Dihydropteroate synthase 1	folP1	0.0017
3807	Dihydropteroate synthase 1	folP1	0.0017
3808	Dihydropteroate synthase 2	folP2	0.0017
88	Retinoic acid receptor RXR-beta	RXRB	0.0017
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0017
1050	Bile salt sulfotransferase	SULT2A1	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0017
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0017
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0016
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
3856	Fibroblast growth factor receptor 3	FGFR3	0.0016
173	Toll-like receptor 7	TLR7	0.0016
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0016
3233	Bile acid receptor	NR1H4	0.0015
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
319	Opioid receptor, sigma 1	OPRS1	0.0015
1629	Transcription factor AP-1	JUN	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
1630	Integrin beta-2	ITGB2	0.0015
1541	Metalloproteinase	mmp20	0.0014
976	Platelet glycoprotein IX	GP9	0.0014
604	Vitamin K-dependent protein Z	PROZ	0.0014
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0014
921	Glutamate receptor 2	GRIA2	0.0014
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0014
936	Ephrin type-A receptor 2	EPHA2	0.0014
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
2216	Fibroblast growth factor receptor 4	FGFR4	0.0014
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0014
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0014
3904	Alanine aminotransferase 2	GPT2	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0013
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0013
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0013
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0013
174	Sigma 1-type opioid receptor	SIGMAR1	0.0013
1650	Heme carrier protein 1	SLC46A1	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6048	Troponin C, skeletal muscle	TNNC2	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0012
719	Retinoic acid receptor responder protein 1	RARRES1	0.0012
770	Retinoic acid-induced protein 3	GPRC5A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
6044	Serum paraoxonase/lactonase 3	PON3	0.0012
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
3809	Estrogen-related receptor gamma	ESRRG	0.0011
484	Tyrosine-protein kinase ABL2	ABL2	0.0011
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0011
365	Dihydrofolate reductase	DHFR	0.0011
2381	Dihydrofolate reductase	DFR1	0.0011
2833	Dihydrofolate reductase	Not Available	0.0011
2931	Dihydrofolate reductase	folA	0.0011
3544	Dihydrofolate reductase	folA	0.0011
3682	Dihydrofolate reductase	folA	0.0011
6642	Dihydrofolate reductase	folA	0.0011
6756	Dihydrofolate reductase	dfrA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0011
1192	Sulfotransferase 1A1	SULT1A1	0.0011
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0011
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0011
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0011
572	Integrin alpha-L	ITGAL	0.0011
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0011
569	Retinal dehydrogenase 2	ALDH1A2	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1864	RET proto-oncogene	RET	0.0011
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.001
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.001
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
6085	Fatty acid-binding protein, intestinal	FABP2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
611	Retinal dehydrogenase 1	ALDH1A1	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
564	Cellular retinoic acid-binding protein 1	CRABP1	0.001
5934	Cytochrome P450 26A1	CYP26A1	0.001
6221	Steroid hormone receptor ERR1	ESRRA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
1039	Histone deacetylase 9	HDAC9	0.0009
908	Glutathione S-transferase theta-1	GSTT1	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0009
183	Vascular endothelial growth factor A	VEGFA	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0008
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0008
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
7	Nitric oxide synthase, inducible	NOS2	0.0008
1867	Major prion protein	PRNP	0.0008
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0008
6432	Transporter	snf	0.0008
162	Retinoic acid receptor gamma-1	RARG	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
896	Glutathione S-transferase Mu 1	GSTM1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
24	Thymidylate synthase	TMP1	0.0007
359	Thymidylate synthase	TYMS	0.0007
2626	Thymidylate synthase	thyA	0.0007
2729	Thymidylate synthase	thyA	0.0007
5352	Thymidylate synthase	THYA	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
164	Histamine H4 receptor	HRH4	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0007
3937	Fatty-acid amide hydrolase	FAAH	0.0006
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0006
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0006
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0006
563	Thyroid peroxidase	TPO	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0005
3810	Catechol O-methyltransferase	COMT	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
6149	Solute carrier family 22 member 10	SLC22A10	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
1992	Vitamin D-binding protein	GC	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
4103	Proteasome subunit beta type 2	PSMB2	0.0004
4101	Proteasome subunit beta type 1	PSMB1	0.0004
4102	Proteasome subunit beta type 5	PSMB5	0.0004
1374	Natriuretic peptides B	NPPB	0.0004
1827	Gap junction alpha-1 protein	GJA1	0.0004
1908	Vascular cell adhesion protein 1	VCAM1	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
4217	Telomerase reverse transcriptase	TERT	0.0004
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0004
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
6146	High affinity copper uptake protein 1	SLC31A1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
2320	Thymidine kinase, cytosolic	TK1	0.0003
291	Nitric-oxide synthase, endothelial	NOS3	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
1275	Estrogen sulfotransferase	SULT1E1	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
517	Alcohol dehydrogenase 1C	ADH1C	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0003
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0003
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0003
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0003
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0003
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0003
6218	Pannexin-1	PANX1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
751	Potassium channel subfamily K member 6	KCNK6	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0003
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0002
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
172	Potassium channel subfamily K member 1	KCNK1	0.0002
3957	Adenosine deaminase	ADA	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0002
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0002
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
2207	Rhodopsin	RHO	0.0002
76	Nitric-oxide synthase, brain	NOS1	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
489	Monocarboxylate transporter 2	SLC16A7	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0001
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00278 - Argatroban

Targets

Enzymes

Predictions