DT-Web: DB00975

Identification

Name

Dipyridamole

Accession Number

DB00975 (APRD00360)

Type

small molecule

Description

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

504.6256

Groups

approved

Monoisotopic Weight

504.317251808

Pharmacology

Indication

For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.

Mechanism of action

Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

Absorption

70%

Protein binding

99%

Biotransformation

hepatic

Route of elimination

Dipyridamole is metabolized in the liver to the glucuronic acid conjugate and excreted with the bile.

Toxicity

Hypotension, if it occurs, is likely to be of short duration, but a vasopressor drug may be used if necessary. The oral LD₅₀ in rats is greater than 6,000 mg/kg while in the dogs, the oral LD₅₀ is approximately 400 mg/kg. LD₅₀=8.4g/kg (orally in rat)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Adenosine	Dipyridamole may increase the effect/toxicity of adenosine.
Fludarabine	Dipyridamole may decrease the effect of fludarabine.
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Regadenoson	Dipyridamole may change the effects of regadenoson. When possible, withhold dipyridamole for at least two days prior to regadenoson administration.
Topotecan	The p-glycoprotein inhibitor, Dipyridamole, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Treprostinil	The prostacyclin analogue, Treprostinil, increases the risk of bleeding when combined with the antiplatelet agent, Dipyridamole. Monitor for increased bleeding during concomitant thearpy. Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.

Food Interactions

Take with food to reduce irritation.
Coffee and tea can decrease the effect of dipyridamole.

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Name	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Gene Name	PDE10A
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Fujishige K, Kotera J, Michibata H, Yuasa K, Takebayashi S, Okumura K, Omori K: Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J Biol Chem. 1999 Jun 25;274(26):18438-45. - Pubmed
DTHybrid score	Not Available
Adenosine deaminase
Name	Adenosine deaminase
Gene Name	ADA
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.3845
cGMP-specific 3',5'-cyclic phosphodiesterase
Name	cGMP-specific 3',5'-cyclic phosphodiesterase
Gene Name	PDE5A
Pharmacological action	yes
Actions	inhibitor
References	Kulkarni SK, Patil CS: Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects. Methods Find Exp Clin Pharmacol. 2004 Dec;26(10):789-99. - Pubmed Santini F, Casali G, Franchi G, Auriemma S, Lusini M, Barozzi L, Favaro A, Messina A, Mazzucco A: Hemodynamic effects of inhaled nitric oxide and phosphodiesterase inhibitor (dipyridamole) on secondary pulmonary hypertension following heart valve surgery in adults. Int J Cardiol. 2005 Aug 18;103(2):156-63. - Pubmed Kruuse C, Lassen LH, Iversen HK, Oestergaard S, Olesen J: Dipyridamole may induce migraine in patients with migraine without aura. Cephalalgia. 2006 Aug;26(8):925-33. - Pubmed Jackson EK, Ren J, Zacharia LC, Mi Z: Characterization of renal ecto-phosphodiesterase. J Pharmacol Exp Ther. 2007 May;321(2):810-5. Epub 2007 Feb 16. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	Not Available
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Name	cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Gene Name	PDE4A
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	Not Available

Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	inhibitor
References	van Aubel RA, Smeets PH, Peters JG, Bindels RJ, Russel FG: The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol. 2002 Mar;13(3):595-603. - Pubmed Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P: Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103. - Pubmed Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003 Aug;38(2):374-84. - Pubmed
DTHybrid score	0.2398
Multidrug resistance-associated protein 5
Name	Multidrug resistance-associated protein 5
Gene Name	ABCC5
Actions	inhibitor
References	Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P: Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103. - Pubmed
DTHybrid score	0.1925
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
DTHybrid score	0.2584

Id	Partner name	Gene Name	Score
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.2298
4512	Cytochrome P450 3A4	CYP3A4	0.1829
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.172
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.1057
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0841
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0837
4118	Cytochrome P450 3A5	CYP3A5	0.0811
4757	Cytochrome P450 2C9	CYP2C9	0.0766
4200	Cytochrome P450 1A2	CYP1A2	0.0765
1178	Adenosine A2a receptor	ADORA2A	0.0764
16	Adenosine A1 receptor	ADORA1	0.0741
5360	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	PDE9A	0.0738
268	Adenosine A2b receptor	ADORA2B	0.0688
4924	Cytochrome P450 2C8	CYP2C8	0.067
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0636
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0632
6142	Solute carrier family 22 member 8	SLC22A8	0.0585
4119	Cytochrome P450 2D6	CYP2D6	0.0573
6143	Solute carrier family 22 member 7	SLC22A7	0.057
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0534
1729	Solute carrier family 22 member 6	SLC22A6	0.0516
6016	Cytochrome P450 2C19	CYP2C19	0.0509
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0497
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.048
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0479
862	Multidrug resistance-associated protein 1	ABCC1	0.0433
901	Glutathione S-transferase Mu 4	GSTM4	0.043
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0422
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0419
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0417
6107	Cytochrome P450 3A7	CYP3A7	0.0412
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0412
587	Serum albumin	ALB	0.041
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0406
20	Prostaglandin G/H synthase 1	PTGS1	0.0396
6013	Cytochrome P450 2E1	CYP2E1	0.0356
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0351
1830	5'-nucleotidase	NT5E	0.0345
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0339
6024	Cytochrome P450 1A1	CYP1A1	0.0337
6030	Cytochrome P450 2B6	CYP2B6	0.0329
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0328
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0318
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.0305
4122	Histone deacetylase 2	HDAC2	0.0301
7	Nitric oxide synthase, inducible	NOS2	0.0295
509	Thymidine kinase	TK	0.0282
570	Thymidine kinase	TK	0.0282
2559	Thymidine kinase	TK	0.0282
3430	Thymidine kinase	tdk	0.0282
3518	Thymidine kinase	TK	0.0282
5301	Thymidine kinase	tdk	0.0282
5771	Thymidine kinase	ORF36	0.0282
7009	Thymidine kinase	ORF36	0.0282
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0281
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.028
6083	Deoxyguanosine kinase, mitochondrial	DGUOK	0.0278
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0271
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0269
5626	Nucleoside diphosphate kinase B	NME2	0.0264
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.026
6171	Solute carrier family 28 member 3	SLC28A3	0.0256
6148	Multidrug resistance-associated protein 7	ABCC10	0.0249
1024	Solute carrier family 22 member 11	SLC22A11	0.0248
290	Prostaglandin G/H synthase 2	PTGS2	0.0236
6144	Solute carrier family 22 member 2	SLC22A2	0.0233
342	P protein [Includes: DNA-directed DNA polymerase	P	0.023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.023
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0226
6137	Multidrug resistance-associated protein 6	ABCC6	0.0226
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0215
3811	Cytochrome P450 19A1	CYP19A1	0.0214
5294	Nucleoside diphosphate kinase A	NME1	0.021
603	DNA polymerase alpha catalytic subunit	POLA1	0.0209
6044	Serum paraoxonase/lactonase 3	PON3	0.0205
4773	Deoxycytidine kinase	DCK	0.02
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0198
6145	Solute carrier family 22 member 1	SLC22A1	0.0198
5718	Cytochrome P450 2A6	CYP2A6	0.0195
776	Bile salt export pump	ABCB11	0.0193
3685	Catabolite gene activator	crp	0.0191
4655	Adenylate cyclase	cyaC	0.0191
4759	Adenylate cyclase	cyaB2	0.0191
1405	Thiopurine S-methyltransferase	TPMT	0.0172
6147	Solute carrier family 22 member 3	SLC22A3	0.0172
6141	Sodium/bile acid cotransporter	SLC10A1	0.0171
24	Thymidylate synthase	TMP1	0.0171
359	Thymidylate synthase	TYMS	0.0171
2626	Thymidylate synthase	thyA	0.0171
2729	Thymidylate synthase	thyA	0.0171
5352	Thymidylate synthase	THYA	0.0171
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0168
2256	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE3B	0.0168
1898	Cytochrome P450 1B1	CYP1B1	0.0167
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0167
4760	Mll3241 protein	mll3241	0.0163
3947	Xanthine dehydrogenase/oxidase	XDH	0.0156
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0153
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0149
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0142
6085	Fatty acid-binding protein, intestinal	FABP2	0.0142
2516	GMP reductase 1	GMPR	0.0141
2361	Response regulator pleD	pleD	0.0141
4106	Guanylate kinase	GUK1	0.0135
4516	Guanylate kinase	gmk	0.0135
492	Histamine H1 receptor	HRH1	0.0134
6020	Aldehyde oxidase	AOX1	0.0134
390	Adenosine A3 receptor	ADORA3	0.013
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0128
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0128
1792	Tissue-type plasminogen activator	PLAT	0.0122
4553	Bifunctional adenosylcobalamin biosynthesis protein cobU	cobU	0.0121
6021	Adenosine kinase	ADK	0.0119
4604	Liver carboxylesterase 1	CES1	0.0119
2966	PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase	pyrR	0.0113
338	DNA polymerase	UL30	0.0113
379	DNA polymerase	UL54	0.0113
697	DNA polymerase	ORF28	0.0113
2482	DNA polymerase	43	0.0113
4104	DNA polymerase	BALF5	0.0113
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0112
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0111
4217	Telomerase reverse transcriptase	TERT	0.011
3923	Cholinesterase	BCHE	0.011
556	Alpha-1A adrenergic receptor	ADRA1A	0.0108
3300	Xanthine phosphoribosyltransferase	xpt	0.0107
3681	Xanthine phosphoribosyltransferase	gpt	0.0107
6167	Organic solute transporter subunit beta	OSTB	0.0104
6166	Organic solute transporter subunit alpha	OSTA	0.0104
4226	Uridine phosphorylase 2	UPP2	0.0103
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0102
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.01
738	Monocarboxylate transporter 1	SLC16A1	0.01
871	Glucocorticoid receptor	NR3C1	0.0099
824	Sodium-dependent serotonin transporter	SLC6A4	0.0099
2684	Histidine triad nucleotide-binding protein 1	HINT1	0.0098
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0097
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0097
2339	Protein-glutamine gamma-glutamyltransferase E	TGM3	0.0096
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0095
193	Beta-1 adrenergic receptor	ADRB1	0.0093
527	Prostacyclin receptor	PTGIR	0.0093
118	Organic cation/carnitine transporter 2	SLC22A5	0.0091
4225	Uridine phosphorylase 1	UPP1	0.0091
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.009
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0089
413	Amidophosphoribosyltransferase	PPAT	0.0088
2515	Amidophosphoribosyltransferase	purF	0.0088
3714	Amidophosphoribosyltransferase	purF	0.0088
831	D(2) dopamine receptor	DRD2	0.0087
6149	Solute carrier family 22 member 10	SLC22A10	0.0087
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0083
468	Cytochrome P450 4A11	CYP4A11	0.0083
2320	Thymidine kinase, cytosolic	TK1	0.0083
136	Estrogen receptor	ESR1	0.0082
1141	Sialidase-1	NEU1	0.008
64	Neuraminidase	NA	0.008
641	Neuraminidase	NA	0.008
2676	Neuraminidase	NA	0.008
3026	Neuraminidase	NA	0.008
3519	Neuraminidase	NA	0.008
6007	Neuraminidase	NA	0.008
26	Vascular endothelial growth factor receptor 3	FLT4	0.008
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0079
504	Mast/stem cell growth factor receptor	KIT	0.0078
32	Vascular endothelial growth factor receptor 1	FLT1	0.0076
952	Dipeptidyl peptidase 4	DPP4	0.0074
908	Glutathione S-transferase theta-1	GSTT1	0.0073
6218	Pannexin-1	PANX1	0.0072
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0072
1648	Elastin	ELN	0.0072
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0072
3639	Thymidine phosphorylase	deoA	0.0072
3936	Thymidine phosphorylase	TYMP	0.0072
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0071
766	Beta-2 adrenergic receptor	ADRB2	0.007
6106	Cytochrome P450 2C18	CYP2C18	0.0068
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0067
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0066
904	Glutathione S-transferase P	GSTP1	0.0065
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0065
817	DNA topoisomerase 2-alpha	TOP2A	0.0065
165	FL cytokine receptor	FLT3	0.0065
407	Vascular endothelial growth factor receptor 2	KDR	0.0065
293	Gamma-glutamyl hydrolase	GGH	0.0064
6220	Aryl hydrocarbon receptor	AHR	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
244	Angiotensin-converting enzyme	ACE	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
5482	Sialidase-2	NEU2	0.0062
896	Glutathione S-transferase Mu 1	GSTM1	0.0061
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0061
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.006
632	Alpha-1B adrenergic receptor	ADRA1B	0.0058
1650	Heme carrier protein 1	SLC46A1	0.0056
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0055
1192	Sulfotransferase 1A1	SULT1A1	0.0055
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0054
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0054
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0054
6182	Cytochrome P450 2J2	CYP2J2	0.0052
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0051
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0051
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0051
320	5-hydroxytryptamine 1A receptor	HTR1A	0.005
789	Alpha-1D adrenergic receptor	ADRA1D	0.005
844	Epidermal growth factor receptor	EGFR	0.005
718	Folate receptor gamma	FOLR3	0.005
299	Folate receptor beta	FOLR2	0.005
804	Mitochondrial folate transporter/carrier	SLC25A32	0.005
731	HIV-1 protease	HIV-1 protease	0.005
1353	DNA topoisomerase 1	TOP1	0.005
3552	DNA topoisomerase 1	topA	0.005
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0049
489	Monocarboxylate transporter 2	SLC16A7	0.0049
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0049
6033	High affinity interleukin-8 receptor A	CXCR1	0.0049
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0049
23	D(1A) dopamine receptor	DRD1	0.0048
847	Mu-type opioid receptor	OPRM1	0.0048
1198	Serum paraoxonase/arylesterase 1	PON1	0.0047
6223	Penicillin-binding protein 1C	pbpC	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
465	Calmodulin	CALM1	0.0046
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0046
318	Alpha-2A adrenergic receptor	ADRA2A	0.0045
6165	Copper-transporting ATPase 1	ATP7A	0.0045
6163	Copper-transporting ATPase 2	ATP7B	0.0045
1313	Lactoylglutathione lyase	GLO1	0.0045
33	Cystine/glutamate transporter	SLC7A11	0.0044
124	Histamine H2 receptor	HRH2	0.0044
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0044
4120	NADPH--cytochrome P450 reductase	POR	0.0043
467	Delta-type opioid receptor	OPRD1	0.0043
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0043
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0043
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0043
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0043
6031	Cytochrome P450 3A43	CYP3A43	0.0043
6146	High affinity copper uptake protein 1	SLC31A1	0.0043
260	Cytochrome P450 51	ERG11	0.0043
761	Cytochrome P450 51	ERG11	0.0043
3163	Cytochrome P450 51	cyp51	0.0043
702	UMP-CMP kinase	CMPK1	0.0042
869	Estrogen receptor beta	ESR2	0.0042
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0041
614	Progesterone receptor	PGR	0.0041
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.004
436	5-hydroxytryptamine 2B receptor	HTR2B	0.004
4034	Glutaredoxin-1	GLRX	0.004
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.004
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.004
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.004
4037	Hypothetical protein	GPX1	0.004
4297	Hypothetical protein	SP_1951	0.004
4521	Hypothetical protein	BC_2969	0.004
4540	Hypothetical protein	TM_1070	0.004
4555	Hypothetical protein	MT1739	0.004
4569	Hypothetical protein	mshD	0.004
4578	Hypothetical protein	PA3270	0.004
4747	Hypothetical protein	PA3967	0.004
5177	Hypothetical protein	TM_0096	0.004
5194	Hypothetical protein	PA1204	0.004
5240	Hypothetical protein	Rv2991	0.004
5370	Hypothetical protein	TM_1158	0.004
5710	Hypothetical protein	Tb927.5.1360	0.004
1928	Leukotriene C4 synthase	LTC4S	0.004
4029	Microsomal glutathione S-transferase 3	MGST3	0.004
4032	Microsomal glutathione S-transferase 1	MGST1	0.004
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.004
4035	Glutathione S-transferase Mu 5	GSTM5	0.004
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.004
4040	Glutathione peroxidase 7	GPX7	0.004
910	Epididymal secretory glutathione peroxidase	GPX5	0.004
4036	Glutathione peroxidase 6	GPX6	0.004
903	Glutathione S-transferase A5	GSTA5	0.004
911	Glutathione peroxidase 3	GPX3	0.004
906	Glutathione peroxidase 1	GPX1	0.004
900	Glutathione S-transferase A4	GSTA4	0.004
4038	Glutathione peroxidase 4	GPX4	0.004
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.004
4042	Glutathione transferase omega-2	GSTO2	0.004
907	Glutathione peroxidase 2	GPX2	0.004
4033	S-formylglutathione hydrolase	ESD	0.004
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.004
284	DNA-directed RNA polymerase beta chain	rpoB	0.004
5773	DNA-directed RNA polymerase beta chain	rpoB	0.004
696	Kappa-type opioid receptor	OPRK1	0.004
474	Acetylcholinesterase	ACHE	0.004
3587	Gastrotropin	FABP6	0.0039
833	Organic cation/carnitine transporter 1	SLC22A4	0.0039
161	Tubulin beta chain	TUBB	0.0039
312	Tubulin beta chain	TUB2	0.0039
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0038
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0038
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0038
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0037
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0037
122	P2Y purinoceptor 12	P2RY12	0.0036
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0036
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0036
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0036
477	DNA topoisomerase 4 subunit A	parC	0.0035
886	DNA topoisomerase 4 subunit A	parC	0.0035
6226	DNA topoisomerase 4 subunit A	parC	0.0035
897	Glutathione S-transferase kappa 1	GSTK1	0.0035
898	Glutathione S-transferase A3	GSTA3	0.0035
3932	Glutathione S-transferase A2	GSTA2	0.0035
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0035
2449	Tubulin alpha-3 chain	TUBA1A	0.0035
404	DNA gyrase subunit A	gyrA	0.0035
6224	DNA gyrase subunit A	gyrA	0.0035
909	Maleylacetoacetate isomerase	GSTZ1	0.0035
899	Glutathione S-transferase Mu 3	GSTM3	0.0034
905	Glutathione transferase omega-1	GSTO1	0.0034
4041	Microsomal glutathione S-transferase 2	MGST2	0.0034
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0034
3941	Amine oxidase [flavin-containing] A	MAOA	0.0033
373	Transthyretin	TTR	0.0033
1757	Myeloperoxidase	MPO	0.0033
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0032
3939	Amine oxidase [flavin-containing] B	MAOB	0.0032
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0032
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0032
2499	Tubulin beta-2C chain	TUBB2C	0.0031
2021	Thrombomodulin	THBD	0.0031
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0031
2165	Glutathione S-transferase Mu 2	GSTM2	0.0031
638	D(3) dopamine receptor	DRD3	0.0031
273	Apoptosis regulator Bcl-2	BCL2	0.0031
207	Glutathione synthetase	GSS	0.0031
5269	Glutathione synthetase	gshB	0.0031
756	Sex hormone-binding globulin	SHBG	0.003
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.003
115	Penicillin-binding protein 2	mrdA	0.003
6069	Penicillin-binding protein 2	mrdA	0.003
6118	Penicillin-binding protein 2	penA	0.003
6187	Penicillin-binding protein 2	pbpA	0.003
6686	Penicillin-binding protein 2	pbp2	0.003
6939	Penicillin-binding protein 2	mrdA	0.003
7163	Penicillin-binding protein 2	pbpA	0.003
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.003
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.003
590	5-hydroxytryptamine 2C receptor	HTR2C	0.003
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0029
380	Cytochrome P450 17A1	CYP17A1	0.0029
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0029
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0029
683	Potassium transporter	GK0582	0.0029
70	Type-1 angiotensin II receptor	AGTR1	0.0029
629	Alpha-2B adrenergic receptor	ADRA2B	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0028
1	Peptidoglycan synthetase ftsI	ftsI	0.0028
4155	Peptidoglycan synthetase ftsI	ftsI	0.0028
645	Penicillin-binding protein 1A	mrcA	0.0028
5805	Penicillin-binding protein 1A	ponA	0.0028
6185	Penicillin-binding protein 1A	mrcA	0.0028
6799	Penicillin-binding protein 1A	pbpA	0.0028
5590	N utilization substance protein B homolog	nusB	0.0028
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0028
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0028
5591	Complement component C8 gamma chain	C8G	0.0028
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0028
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0028
5587	Iron(III)-binding periplasmic protein	fbpA	0.0028
2838	Ribose-5-phosphate isomerase A	rpiA	0.0028
2952	Ribose-5-phosphate isomerase A	rpiA	0.0028
5595	Ribose-5-phosphate isomerase A	rpiA	0.0028
4695	UPF0124 protein yfiH	yfiH	0.0028
5060	Intron-associated endonuclease 1	ITEVIR	0.0028
5593	Transferase	Not Available	0.0028
5581	Beta-fructosidase	bfrA	0.0028
5588	Cell division protein FtsY	TM_0570	0.0028
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0028
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0028
5600	Pyruvate decarboxylase	pdc	0.0028
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0028
4375	Glutamine synthetase 1	glnA1	0.0028
5575	Short tail fiber protein	12	0.0028
5574	Invasin	YPTB1668	0.0028
5580	Hexon protein	PII	0.0028
6138	Multidrug resistance protein 3	ABCB4	0.0028
737	Mineralocorticoid receptor	NR3C2	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
777	Tumor necrosis factor	TNF	0.0027
4237	50S ribosomal protein L22	rplV	0.0027
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0027
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0027
4992	Cytochrome c peroxidase	Not Available	0.0027
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0027
818	50S ribosomal protein L10	rplJ	0.0026
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0026
4031	Glutathione S-transferase A1	GSTA1	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0026
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
1852	Microtubule-associated protein 2	MAP2	0.0026
29	Tubulin beta-1 chain	TUBB1	0.0025
714	Glutathione reductase, mitochondrial	GSR	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
146	Androgen receptor	AR	0.0025
3132	Tryptophan synthase alpha chain	trpA	0.0025
6568	Tryptophan synthase alpha chain	trpA	0.0025
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0024
185	Vasopressin V1a receptor	AVPR1A	0.0024
3729	Citrate synthase	gltA	0.0024
4575	Citrate synthase	cit	0.0024
4580	Citrate synthase	gltA	0.0024
5328	Prostaglandin F synthase	Tb11.02.2310	0.0024
5006	RNASE4 protein	RNASE4	0.0024
2555	Pol polyprotein	pol	0.0024
3242	Pol polyprotein	gag-pol	0.0024
3471	Pol polyprotein	gag-pro-pol	0.0024
5256	Pol polyprotein	pol	0.0024
6469	Pol polyprotein	gag-pol	0.0024
6565	Pol polyprotein	Not Available	0.0024
4533	Glyoxalase family protein	BC_1747	0.0024
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0024
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0024
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0024
319	Opioid receptor, sigma 1	OPRS1	0.0024
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0024
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0024
322	Vasopressin V2 receptor	AVPR2	0.0024
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0024
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0024
5818	Folate receptor alpha	FOLR1	0.0024
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0024
4103	Proteasome subunit beta type 2	PSMB2	0.0023
4102	Proteasome subunit beta type 5	PSMB5	0.0023
4101	Proteasome subunit beta type 1	PSMB1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
365	Dihydrofolate reductase	DHFR	0.0023
2381	Dihydrofolate reductase	DFR1	0.0023
2833	Dihydrofolate reductase	Not Available	0.0023
2931	Dihydrofolate reductase	folA	0.0023
3544	Dihydrofolate reductase	folA	0.0023
3682	Dihydrofolate reductase	folA	0.0023
6642	Dihydrofolate reductase	folA	0.0023
6756	Dihydrofolate reductase	dfrA	0.0023
6042	Prostaglandin reductase 2	PTGR2	0.0023
713	Sodium-dependent dopamine transporter	SLC6A3	0.0023
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0023
2521	Cell division protein ftsZ	ftsZ	0.0023
3301	Cell division protein ftsZ	ftsZ	0.0023
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0023
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0022
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0022
2603	Beta-lactamase II	blm	0.0022
2149	Angiogenin	ANG	0.0022
3583	6-phosphogluconolactonase	pgl	0.0022
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0022
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0022
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0022
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0022
3810	Catechol O-methyltransferase	COMT	0.0022
716	5-hydroxytryptamine 7 receptor	HTR7	0.0021
857	Malate dehydrogenase, mitochondrial	MDH2	0.0021
2391	Ferrochelatase	hemH	0.0021
6502	Ferrochelatase	DKFZp686P18130	0.0021
1591	Ferrochelatase, mitochondrial	FECH	0.0021
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0021
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0021
6043	Putative G-protein coupled receptor 44	GPR44	0.0021
3486	Fumarate hydratase class II	fumC	0.0021
2286	Isocitrate dehydrogenase [NADP]	icd	0.0021
2302	Isocitrate dehydrogenase [NADP]	icd	0.0021
2771	Isocitrate dehydrogenase [NADP]	icd	0.0021
2942	Sialidase	nanH	0.0021
3546	Sialidase	nedA	0.0021
3809	Estrogen-related receptor gamma	ESRRG	0.0021
378	Alpha-2C adrenergic receptor	ADRA2C	0.0021
1123	Eosinophil cationic protein	RNASE3	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0021
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.002
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.002
332	Beta-lactamase	blaZ	0.002
2478	Beta-lactamase	ampC	0.002
2613	Beta-lactamase	ampC	0.002
2635	Beta-lactamase	ampC	0.002
2700	Beta-lactamase	penP	0.002
5445	Beta-lactamase	blaB	0.002
6019	Beta-lactamase	SHV-7	0.002
6701	Beta-lactamase	cphA	0.002
2697	Uridine-cytidine kinase 2	UCK2	0.002
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.002
2452	Tryptophanyl-tRNA synthetase	trpS	0.002
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.002
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.002
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.002
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.002
1656	CYP2B protein	CYP2B	0.002
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.002
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0019
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0019
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0019
411	Glycine N-methyltransferase	GNMT	0.0019
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
239	Coagulation factor X	F10	0.0019
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0019
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0019
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0019
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0019
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0019
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0019
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0019
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0019
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0019
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0019
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0019
6559	Cytochrome c oxidase subunit 2	ctaC	0.0019
6669	Cytochrome c oxidase subunit 2	ctaC	0.0019
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0019
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0019
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0019
6558	Cytochrome c oxidase subunit 1	ctaD	0.0019
5579	Carboxypeptidase B	CPB1	0.0018
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0018
3384	Macrophage migration inhibitory factor	MIF	0.0018
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0018
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0018
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0018
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0018
128	Adenine phosphoribosyltransferase	APRT	0.0018
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0017
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0017
594	Thyroxine-binding globulin	SERPINA7	0.0017
2540	Choloylglycine hydrolase	cbh	0.0017
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0017
768	FK506-binding protein 1A	FKBP1A	0.0017
2539	Tubulin alpha-1 chain	TUBA4A	0.0016
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0016
6824	Tyrosine-protein kinase Lyn	LYN	0.0016
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
5300	Antigen peptide transporter 1	TAP1	0.0016
6501	Fatty acid-binding protein, liver	FABP1	0.0016
2599	Tyrosine-protein kinase HCK	HCK	0.0016
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0016
758	Thyroid hormone receptor alpha	THRA	0.0016
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0016
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0015
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0015
6755	Poliovirus receptor	PVR	0.0015
275	Arachidonate 5-lipoxygenase	ALOX5	0.0015
1517	Beta-3 adrenergic receptor	ADRB3	0.0015
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0015
605	Fumarate reductase flavoprotein subunit	frdA	0.0015
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0015
3673	Fumarate reductase flavoprotein subunit	fccA	0.0015
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0015
6549	Fumarate reductase flavoprotein subunit	frdA	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
5682	Ribonuclease pancreatic	RNASE1	0.0014
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0014
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0014
822	Aldose reductase	AKR1B1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
346	Thyroid hormone receptor beta-1	THRB	0.0014
1629	Transcription factor AP-1	JUN	0.0014
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0014
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0014
6500	Phospholipase A2	PLA2G1B	0.0013
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0013
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0013
1010	Cytochrome P450 51A1	CYP51A1	0.0013
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0013
6432	Transporter	snf	0.0013
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0012
3856	Fibroblast growth factor receptor 3	FGFR3	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0012
694	Matrix protein 2	M	0.0012
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0012
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0012
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0012
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0012
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0012
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0012
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0012
517	Alcohol dehydrogenase 1C	ADH1C	0.0012
461	Glycine receptor subunit alpha-3	GLRA3	0.0012
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0012
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0012
6859	Protein S100-A4	S100A4	0.0012
432	D(4) dopamine receptor	DRD4	0.0012
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2112	Toll-like receptor 9	TLR9	0.0011
469	Annexin A1	ANXA1	0.0011
5923	Microtubule-associated protein tau	MAPT	0.0011
5924	Microtubule-associated protein 4	MAP4	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
6459	Glycodelin	PAEP	0.0011
1618	High affinity nerve growth factor receptor	NTRK1	0.0011
232	Corticosteroid-binding globulin	SERPINA6	0.0011
131	Synaptic vesicular amine transporter	SLC18A2	0.0011
427	Substance-P receptor	TACR1	0.0011
144	Hemoglobin subunit alpha	HBA1	0.001
106	Cannabinoid receptor 2	CNR2	0.001
6174	50S ribosomal protein L32	rpmF	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
811	Translocator protein	TSPO	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.001
890	Niemann-Pick C1-like protein 1	NPC1L1	0.001
723	Cytosolic phospholipase A2	PLA2G4A	0.001
68	Cannabinoid receptor 1	CNR1	0.001
199	Monocarboxylate transporter 8	SLC16A2	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
4192	DNA topoisomerase 2-beta	TOP2B	0.001
936	Ephrin type-A receptor 2	EPHA2	0.0009
3611	Cytidine deaminase	cdd	0.0009
3707	Cytidine deaminase	cdd	0.0009
4211	Cytidine deaminase	CDA	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0009
1291	cAMP response element-binding protein	CREB1	0.0009
1525	Heparin-binding growth factor 2	FGF2	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1569	G1/S-specific cyclin-D1	CCND1	0.0009
2240	Cell division protein kinase 2	CDK2	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
4210	Toll-like receptor 4	TLR4	0.0009
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0009
1760	Aminopeptidase N	ANPEP	0.0009
6843	Aminopeptidase N	pepN	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
54	Prothrombin	F2	0.0009
1262	Corticotropin-lipotropin	POMC	0.0009
117	Sterol O-acyltransferase 1	SOAT1	0.0008
5787	Angiopoietin-1 receptor	TEK	0.0008
823	Fibroblast growth factor receptor 2	FGFR2	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
6211	Tubulin epsilon chain	TUBE1	0.0008
6212	Tubulin gamma-1 chain	TUBG1	0.0008
6210	Tubulin delta chain	TUBD1	0.0008
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
484	Tyrosine-protein kinase ABL2	ABL2	0.0008
780	Retinoic acid receptor RXR-gamma	RXRG	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1714	Mitogen-activated protein kinase 3	MAPK3	0.0008
459	Retinoic acid receptor RXR-alpha	RXRA	0.0007
88	Retinoic acid receptor RXR-beta	RXRB	0.0007
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0007
162	Retinoic acid receptor gamma-1	RARG	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0007
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0007
163	D(1B) dopamine receptor	DRD5	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
1630	Integrin beta-2	ITGB2	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
976	Platelet glycoprotein IX	GP9	0.0007
1374	Natriuretic peptides B	NPPB	0.0006
1827	Gap junction alpha-1 protein	GJA1	0.0006
1908	Vascular cell adhesion protein 1	VCAM1	0.0006
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
814	Ryanodine receptor 1	RYR1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
1176	Mitogen-activated protein kinase 1	MAPK1	0.0006
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0006
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
174	Sigma 1-type opioid receptor	SIGMAR1	0.0006
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0006
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0006
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0006
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0006
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0005
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0005
2207	Rhodopsin	RHO	0.0005
5798	Mitogen-activated protein kinase 11	MAPK11	0.0005
572	Integrin alpha-L	ITGAL	0.0005
183	Vascular endothelial growth factor A	VEGFA	0.0005
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0005
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0005
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0005
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0005
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0005
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
1864	RET proto-oncogene	RET	0.0005
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0005
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0005
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
1275	Estrogen sulfotransferase	SULT1E1	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
1050	Bile salt sulfotransferase	SULT2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3221	Cytochrome c4	cc4	0.0005
291	Nitric-oxide synthase, endothelial	NOS3	0.0004
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0004
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0004
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0004
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0004
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0004
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0004
6102	Arylamine N-acetyltransferase 2	NAT2	0.0004
5934	Cytochrome P450 26A1	CYP26A1	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
751	Potassium channel subfamily K member 6	KCNK6	0.0004
4311	tRNA	TRDMT1	0.0004
4325	tRNA	trmD	0.0004
4328	tRNA	trmD	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0004
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0004
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0004
172	Potassium channel subfamily K member 1	KCNK1	0.0004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0004
84	Nuclear receptor 0B1	NR0B1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
6168	Solute carrier family 22 member 16	SLC22A16	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0004
6014	Cytochrome P450 2A13	CYP2A13	0.0003
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
295	Carbonic anhydrase 1	CA1	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
164	Histamine H4 receptor	HRH4	0.0003
76	Nitric-oxide synthase, brain	NOS1	0.0002
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0002
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0002
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0002
921	Glutamate receptor 2	GRIA2	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00975 - Dipyridamole

Targets

Transporters

Predictions