DT-Web

DB00633 - Dexmedetomidine


Identification
Name Dexmedetomidine
Accession Number DB00633 (APRD00578)
Type small molecule
Description An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 200.2795
Groups approved
Monoisotopic Weight 200.131348522
Pharmacology
Indication For sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting, also used in pain relief; anxiety reduction and analgesia
Mechanism of action Dexmedetomidine is a specific and selective alpha-2 adrenoceptor agonist. By binding to the presynaptic alpha-2 adrenoceptors, it inhibits the release if norepinephrine, therefore, terminate the propagation of pain signals. Activation of the postsynaptic alpha-2 adrenoceptors inhibits the sympathetic activity decreases blood pressure and heart rate.
Absorption Not Available
Protein binding 94%
Biotransformation Hepatic
Route of elimination A mass balance study demonstrated that after nine days an average of 95% of the radioactivity, following intravenous administration of radiolabeled dexmedetomidine, was recovered in the urine and 4% in the feces. Fractionation of the radioactivity excreted in urine demonstrated that products of N-glucuronidation accounted for approximately 34% of the cumulative urinary excretion. The majority of metabolites are excreted in the urine.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Tranylcypromine Tranylcypromine, a strong CYP2A6 inhibitor, may decrease the metabolism and clearance of Dexmedetomidine.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Trimipramine Trimipramine may reduce the antihypertensive effect of the alpha2-agonist, Dexmedetomidine. Trimipramine may also increase the rebound hypertensive effect of Clonidine. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Clonidine if Trimipramine is initiated, discontinued or dose changed. Dexmedetomidine should be withdrawn very gradually to reduce the risk of hypertensive crisis.
Food Interactions Not Available

Targets


Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action yes
Actions agonist
References
  • Fairbanks CA, Stone LS, Kitto KF, Nguyen HO, Posthumus IJ, Wilcox GL: alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J Pharmacol Exp Ther. 2002 Jan;300(1):282-90. - Pubmed
  • Scheibner J, Trendelenburg AU, Hein L, Starke K, Blandizzi C: Alpha 2-adrenoceptors in the enteric nervous system: a study in alpha 2A-adrenoceptor-deficient mice. Br J Pharmacol. 2002 Feb;135(3):697-704. - Pubmed
  • Davies MF, Tsui J, Flannery JA, Li X, DeLorey TM, Hoffman BB: Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology. 2004 Feb;29(2):229-39. - Pubmed
  • Dawson C, Ma D, Chow A, Maze M: Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action. Anesthesiology. 2004 Apr;100(4):894-904. - Pubmed
  • Ozdogan UK, Lahdesmaki J, Hakala K, Scheinin M: The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol. 2004 Aug 23;497(2):161-71. - Pubmed
  • Menon DV, Wang Z, Fadel PJ, Arbique D, Leonard D, Li JL, Victor RG, Vongpatanasin W: Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol. 2007 Aug 14;50(7):626-33. Epub 2007 Jul 30. - Pubmed
DTHybrid score 0.2681

Enzymes


Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Avsaroglu H, Bull S, Maas-Bakker RF, Scherpenisse P, Van Lith HA, Bergwerff AA, Hellebrekers LJ, Van Zutphen LF, Fink-Gremmels J: Differences in hepatic cytochrome P450 activity correlate with the strain-specific biotransformation of medetomidine in AX/JU and IIIVO/JU inbred rabbits. J Vet Pharmacol Ther. 2008 Aug;31(4):368-77. - Pubmed
  • Duhamel MC, Troncy E, Beaudry F: Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes. Biomed Chromatogr. 2010 Aug;24(8):868-77. - Pubmed
DTHybrid score 0.2497
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Konstandi M, Lang MA, Kostakis D, Johnson EO, Marselos M: Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene. Basic Clin Pharmacol Toxicol. 2008 Jan;102(1):35-44. Epub 2007 Oct 31. - Pubmed
  • Konstandi M, Kostakis D, Harkitis P, Johnson EO, Marselos M, Adamidis K, Lang MA: Benzo(alpha)pyrene-induced up-regulation of CYP1A2 gene expression: role of adrenoceptor-linked signaling pathways. Life Sci. 2006 Jun 20;79(4):331-41. Epub 2006 Feb 28. - Pubmed
DTHybrid score 0.391
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Konstandi M, Kostakis D, Harkitis P, Marselos M, Johnson EO, Adamidis K, Lang MA: Role of adrenoceptor-linked signaling pathways in the regulation of CYP1A1 gene expression. Biochem Pharmacol. 2005 Jan 15;69(2):277-87. - Pubmed
DTHybrid score 0.239
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Rodrigues AD, Roberts EM: The in vitro interaction of dexmedetomidine with human liver microsomal cytochrome P4502D6 (CYP2D6). Drug Metab Dispos. 1997 May;25(5):651-5. - Pubmed
DTHybrid score 0.368

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2808
4757 Cytochrome P450 2C9 CYP2C9 0.1708
6016 Cytochrome P450 2C19 CYP2C19 0.1587
1588 Multidrug resistance protein 1 ABCB1 0.1289
556 Alpha-1A adrenergic receptor ADRA1A 0.1268
4924 Cytochrome P450 2C8 CYP2C8 0.1123
6030 Cytochrome P450 2B6 CYP2B6 0.1061
4118 Cytochrome P450 3A5 CYP3A5 0.1022
5718 Cytochrome P450 2A6 CYP2A6 0.0834
6107 Cytochrome P450 3A7 CYP3A7 0.0737
378 Alpha-2C adrenergic receptor ADRA2C 0.0736
629 Alpha-2B adrenergic receptor ADRA2B 0.0736
502 5-hydroxytryptamine 2A receptor HTR2A 0.0699
492 Histamine H1 receptor HRH1 0.0684
23 D(1A) dopamine receptor DRD1 0.0624
831 D(2) dopamine receptor DRD2 0.061
824 Sodium-dependent serotonin transporter SLC6A4 0.0555
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0513
590 5-hydroxytryptamine 2C receptor HTR2C 0.0504
320 5-hydroxytryptamine 1A receptor HTR1A 0.0504
632 Alpha-1B adrenergic receptor ADRA1B 0.0474
1898 Cytochrome P450 1B1 CYP1B1 0.0457
766 Beta-2 adrenergic receptor ADRB2 0.0454
193 Beta-1 adrenergic receptor ADRB1 0.0445
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0426
885 5-hydroxytryptamine 1B receptor HTR1B 0.0397
20 Prostaglandin G/H synthase 1 PTGS1 0.0386
587 Serum albumin ALB 0.0371
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0369
725 5-hydroxytryptamine 1D receptor HTR1D 0.0369
638 D(3) dopamine receptor DRD3 0.036
6145 Solute carrier family 22 member 1 SLC22A1 0.0355
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0355
3941 Amine oxidase [flavin-containing] A MAOA 0.035
713 Sodium-dependent dopamine transporter SLC6A3 0.0342
163 D(1B) dopamine receptor DRD5 0.0309
789 Alpha-1D adrenergic receptor ADRA1D 0.03
432 D(4) dopamine receptor DRD4 0.0298
6144 Solute carrier family 22 member 2 SLC22A2 0.0295
118 Organic cation/carnitine transporter 2 SLC22A5 0.0282
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0279
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0274
341 5-hydroxytryptamine 3 receptor HTR3A 0.0272
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0267
36 Insulin receptor INSR 0.0258
3811 Cytochrome P450 19A1 CYP19A1 0.0258
436 5-hydroxytryptamine 2B receptor HTR2B 0.0254
6106 Cytochrome P450 2C18 CYP2C18 0.0253
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0244
1729 Solute carrier family 22 member 6 SLC22A6 0.0238
6147 Solute carrier family 22 member 3 SLC22A3 0.023
290 Prostaglandin G/H synthase 2 PTGS2 0.0226
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0224
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.022
3939 Amine oxidase [flavin-containing] B MAOB 0.0218
465 Calmodulin CALM1 0.0216
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0216
862 Multidrug resistance-associated protein 1 ABCC1 0.0212
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0212
468 Cytochrome P450 4A11 CYP4A11 0.0207
716 5-hydroxytryptamine 7 receptor HTR7 0.0206
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0206
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0193
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0192
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0188
776 Bile salt export pump ABCB11 0.0188
833 Organic cation/carnitine transporter 1 SLC22A4 0.0179
817 DNA topoisomerase 2-alpha TOP2A 0.0177
777 Tumor necrosis factor TNF 0.0171
131 Synaptic vesicular amine transporter SLC18A2 0.017
1517 Beta-3 adrenergic receptor ADRB3 0.0169
16 Adenosine A1 receptor ADORA1 0.0169
613 Atrial natriuretic peptide receptor A NPR1 0.0161
136 Estrogen receptor ESR1 0.0158
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0156
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0153
6014 Cytochrome P450 2A13 CYP2A13 0.0151
3923 Cholinesterase BCHE 0.0147
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0147
477 DNA topoisomerase 4 subunit A parC 0.0144
886 DNA topoisomerase 4 subunit A parC 0.0144
6226 DNA topoisomerase 4 subunit A parC 0.0144
1178 Adenosine A2a receptor ADORA2A 0.0143
404 DNA gyrase subunit A gyrA 0.0141
6224 DNA gyrase subunit A gyrA 0.0141
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0136
847 Mu-type opioid receptor OPRM1 0.0136
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.013
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.013
260 Cytochrome P450 51 ERG11 0.0129
761 Cytochrome P450 51 ERG11 0.0129
3163 Cytochrome P450 51 cyp51 0.0129
790 DNA polymerase subunit alpha B POLA2 0.0129
696 Kappa-type opioid receptor OPRK1 0.0126
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0122
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0122
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0122
3810 Catechol O-methyltransferase COMT 0.0122
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0119
1256 5-hydroxytryptamine 6 receptor HTR6 0.0118
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0116
48 Pyridoxal kinase PDXK 0.0116
6220 Aryl hydrocarbon receptor AHR 0.0115
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0115
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0114
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0114
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0109
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0109
467 Delta-type opioid receptor OPRD1 0.0108
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0107
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0107
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0106
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0106
3947 Xanthine dehydrogenase/oxidase XDH 0.0105
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0105
6031 Cytochrome P450 3A43 CYP3A43 0.0102
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0102
1757 Myeloperoxidase MPO 0.0101
2164 Multidrug resistance-associated protein 4 ABCC4 0.01
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.01
6142 Solute carrier family 22 member 8 SLC22A8 0.01
124 Histamine H2 receptor HRH2 0.01
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0099
6070 Nischarin NISCH 0.0099
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0098
6020 Aldehyde oxidase AOX1 0.0097
1010 Cytochrome P450 51A1 CYP51A1 0.0097
482 Glycine receptor subunit alpha-1 GLRA1 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
871 Glucocorticoid receptor NR3C1 0.0095
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0094
2499 Tubulin beta-2C chain TUBB2C 0.0094
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0093
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0093
2449 Tubulin alpha-3 chain TUBA1A 0.0092
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0091
94 5-hydroxytryptamine 4 receptor HTR4 0.009
6766 O-GlcNAcase BT_4395 BT_4395 0.0089
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0089
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0087
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0087
4122 Histone deacetylase 2 HDAC2 0.0087
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0086
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0083
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0083
6143 Solute carrier family 22 member 7 SLC22A7 0.0082
528 5-hydroxytryptamine 1E receptor HTR1E 0.0082
731 HIV-1 protease HIV-1 protease 0.0082
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.008
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.008
3426 Glutamine synthetase glnA 0.008
3987 Glutamine synthetase GLUL 0.008
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.008
4228 Keratin, type II cytoskeletal 7 KRT7 0.0079
6102 Arylamine N-acetyltransferase 2 NAT2 0.0079
6148 Multidrug resistance-associated protein 7 ABCC10 0.0079
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0078
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0077
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0076
3932 Glutathione S-transferase A2 GSTA2 0.0075
537 ATP synthase delta chain, mitochondrial ATP5D 0.0074
2112 Toll-like receptor 9 TLR9 0.0073
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.007
828 Phenylalanine-4-hydroxylase PAH 0.0069
3109 Phenylalanine-4-hydroxylase phhA 0.0069
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0069
380 Cytochrome P450 17A1 CYP17A1 0.0069
474 Acetylcholinesterase ACHE 0.0069
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0068
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0068
705 Glutamate receptor 1 GRIA1 0.0068
4120 NADPH--cytochrome P450 reductase POR 0.0067
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0067
820 Glycine receptor subunit alpha-2 GLRA2 0.0067
571 Melatonin receptor type 1A MTNR1A 0.0066
362 Melatonin receptor type 1B MTNR1B 0.0066
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0065
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0065
844 Epidermal growth factor receptor EGFR 0.0065
373 Transthyretin TTR 0.0064
1820 Beta-nerve growth factor NGF 0.0064
173 Toll-like receptor 7 TLR7 0.0063
251 Alcohol dehydrogenase 1A ADH1A 0.0063
565 Extracellular calcium-sensing receptor CASR 0.0062
444 Alcohol dehydrogenase 1B ADH1B 0.0062
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0062
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0062
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0062
122 P2Y purinoceptor 12 P2RY12 0.006
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0059
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0059
6182 Cytochrome P450 2J2 CYP2J2 0.0058
33 Cystine/glutamate transporter SLC7A11 0.0058
1636 Trace amine-associated receptor 1 TAAR1 0.0058
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0058
4604 Liver carboxylesterase 1 CES1 0.0057
1656 CYP2B protein CYP2B 0.0057
4311 tRNA TRDMT1 0.0057
4325 tRNA trmD 0.0057
4328 tRNA trmD 0.0057
1192 Sulfotransferase 1A1 SULT1A1 0.0057
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0057
6146 High affinity copper uptake protein 1 SLC31A1 0.0055
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0055
4203 Histamine N-methyltransferase HNMT 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
823 Fibroblast growth factor receptor 2 FGFR2 0.0052
1714 Mitogen-activated protein kinase 3 MAPK3 0.0052
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0052
504 Mast/stem cell growth factor receptor KIT 0.0051
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0051
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0051
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.005
891 Dihydropteroate synthase folP 0.005
5359 Dihydropteroate synthase folP 0.005
7175 Dihydropteroate synthase sulI 0.005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.005
869 Estrogen receptor beta ESR2 0.0049
1024 Solute carrier family 22 member 11 SLC22A11 0.0049
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0048
146 Androgen receptor AR 0.0048
517 Alcohol dehydrogenase 1C ADH1C 0.0048
295 Carbonic anhydrase 1 CA1 0.0047
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0047
1629 Transcription factor AP-1 JUN 0.0047
904 Glutathione S-transferase P GSTP1 0.0047
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0046
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0046
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0045
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0044
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0044
976 Platelet glycoprotein IX GP9 0.0044
390 Adenosine A3 receptor ADORA3 0.0044
365 Dihydrofolate reductase DHFR 0.0044
2381 Dihydrofolate reductase DFR1 0.0044
2833 Dihydrofolate reductase Not Available 0.0044
2931 Dihydrofolate reductase folA 0.0044
3544 Dihydrofolate reductase folA 0.0044
3682 Dihydrofolate reductase folA 0.0044
6642 Dihydrofolate reductase folA 0.0044
6756 Dihydrofolate reductase dfrA 0.0044
6136 Multidrug resistance-associated protein 5 ABCC5 0.0044
1374 Natriuretic peptides B NPPB 0.0044
1827 Gap junction alpha-1 protein GJA1 0.0043
6141 Sodium/bile acid cotransporter SLC10A1 0.0043
1908 Vascular cell adhesion protein 1 VCAM1 0.0043
228 Beta platelet-derived growth factor receptor PDGFRB 0.0043
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0043
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0043
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0043
3957 Adenosine deaminase ADA 0.0043
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0043
6126 Carbonic anhydrase 7 CA7 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
511 5-hydroxytryptamine 1F receptor HTR1F 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
518 Peroxidase/catalase T katG 0.0042
2236 Casein kinase II subunit alpha CSNK2A1 0.0041
811 Translocator protein TSPO 0.0041
814 Ryanodine receptor 1 RYR1 0.0041
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0041
3404 Exotoxin A eta 0.004
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.004
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.004
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.004
921 Glutamate receptor 2 GRIA2 0.004
634 Squalene monooxygenase SQLE 0.004
7196 Squalene monooxygenase ERG1 0.004
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0039
1050 Bile salt sulfotransferase SULT2A1 0.0039
563 Thyroid peroxidase TPO 0.0039
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0039
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0039
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0039
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
3937 Fatty-acid amide hydrolase FAAH 0.0039
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0039
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0039
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0039
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0039
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0039
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
6432 Transporter snf 0.0039
908 Glutathione S-transferase theta-1 GSTT1 0.0039
161 Tubulin beta chain TUBB 0.0039
312 Tubulin beta chain TUB2 0.0039
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0038
153 Dopamine beta-hydroxylase DBH 0.0038
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0038
3917 Methylenetetrahydrofolate reductase MTHFR 0.0038
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0038
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0038
1176 Mitogen-activated protein kinase 1 MAPK1 0.0038
400 Coagulation factor IX F9 0.0037
5461 Coagulation factor IX F9 0.0037
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0037
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0037
268 Adenosine A2b receptor ADORA2B 0.0037
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0036
6043 Putative G-protein coupled receptor 44 GPR44 0.0036
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
6137 Multidrug resistance-associated protein 6 ABCC6 0.0035
473 L-lactate dehydrogenase A chain LDHA 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
592 Carbonic anhydrase 4 CA4 0.0034
164 Histamine H4 receptor HRH4 0.0034
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0034
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0034
273 Apoptosis regulator Bcl-2 BCL2 0.0034
604 Vitamin K-dependent protein Z PROZ 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
712 Tubulin alpha chain TUB1 0.0034
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0034
183 Vascular endothelial growth factor A VEGFA 0.0033
4116 Dihydropteroate synthetase Not Available 0.0033
6506 Stathmin-4 STMN4 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
84 Nuclear receptor 0B1 NR0B1 0.0033
6044 Serum paraoxonase/lactonase 3 PON3 0.0033
4192 DNA topoisomerase 2-beta TOP2B 0.0032
2290 ADP-ribosyl cyclase 2 BST1 0.0032
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0032
174 Sigma 1-type opioid receptor SIGMAR1 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
422 Vitamin K-dependent protein C PROC 0.0031
1245 Vitamin K-dependent protein S PROS1 0.0031
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0031
26 Vascular endothelial growth factor receptor 3 FLT4 0.0031
1618 High affinity nerve growth factor receptor NTRK1 0.0031
5934 Cytochrome P450 26A1 CYP26A1 0.0031
1275 Estrogen sulfotransferase SULT1E1 0.0031
65 Matrix metalloproteinase-9 Not Available 0.0031
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0031
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0031
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0031
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.003
818 50S ribosomal protein L10 rplJ 0.003
4103 Proteasome subunit beta type 2 PSMB2 0.003
4102 Proteasome subunit beta type 5 PSMB5 0.003
4101 Proteasome subunit beta type 1 PSMB1 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
32 Vascular endothelial growth factor receptor 1 FLT1 0.003
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
275 Arachidonate 5-lipoxygenase ALOX5 0.0028
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0028
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0028
1253 Interferon gamma IFNG 0.0028
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0028
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0028
6163 Copper-transporting ATPase 2 ATP7B 0.0028
6165 Copper-transporting ATPase 1 ATP7A 0.0028
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0028
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0028
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0028
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0027
407 Vascular endothelial growth factor receptor 2 KDR 0.0027
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3830 Calreticulin CALR 0.0027
581 Cytochrome P450 2R1 CYP2R1 0.0026
106 Cannabinoid receptor 2 CNR2 0.0026
172 Potassium channel subfamily K member 1 KCNK1 0.0026
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0026
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0026
357 Carbonic anhydrase 2 CA2 0.0026
284 DNA-directed RNA polymerase beta chain rpoB 0.0026
5773 DNA-directed RNA polymerase beta chain rpoB 0.0026
756 Sex hormone-binding globulin SHBG 0.0025
798 Osteocalcin BGLAP 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6034 Hydroxyindole O-methyltransferase ASMT 0.0025
6035 Nuclear receptor ROR-beta RORB 0.0025
6036 Eosinophil peroxidase EPX 0.0025
1992 Vitamin D-binding protein GC 0.0025
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0025
68 Cannabinoid receptor 1 CNR1 0.0025
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0024
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
7 Nitric oxide synthase, inducible NOS2 0.0024
239 Coagulation factor X F10 0.0024
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0024
1063 Signal transducer and activator of transcription 5B STAT5B 0.0024
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0024
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0024
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1569 G1/S-specific cyclin-D1 CCND1 0.0023
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
369 Coagulation factor VII F7 0.0023
822 Aldose reductase AKR1B1 0.0023
358 Cystathionine beta-synthase CBS 0.0023
896 Glutathione S-transferase Mu 1 GSTM1 0.0023
70 Type-1 angiotensin II receptor AGTR1 0.0023
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
233 Potassium channel subfamily K member 2 KCNK2 0.0022
765 Indoleamine 2,3-dioxygenase IDO1 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
3809 Estrogen-related receptor gamma ESRRG 0.0021
997 Protein kinase C beta type PRKCB 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0021
614 Progesterone receptor PGR 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0021
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.002
859 Cellular retinoic acid-binding protein 2 CRABP2 0.002
319 Opioid receptor, sigma 1 OPRS1 0.002
2298 Cytochrome P450-cam camC 0.002
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.002
1970 Protein kinase C alpha type PRKCA 0.002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.002
780 Retinoic acid receptor RXR-gamma RXRG 0.002
3007 Carbonic anhydrase 12 CA12 0.002
4205 Carbonic anhydrase 9 CA9 0.002
936 Ephrin type-A receptor 2 EPHA2 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0019
2408 Tyrosine-protein kinase SYK SYK 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
469 Annexin A1 ANXA1 0.0019
723 Cytosolic phospholipase A2 PLA2G4A 0.0019
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0019
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0019
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0019
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0019
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0019
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
737 Mineralocorticoid receptor NR3C2 0.0018
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0018
856 Vitamin D3 receptor VDR 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
543 Penicillin-binding protein 1B mrcB 0.0018
6186 Penicillin-binding protein 1B ponB 0.0018
6822 Penicillin-binding protein 1b pbp1b 0.0018
6844 Penicillin-binding protein 1b pbp1b 0.0018
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
645 Penicillin-binding protein 1A mrcA 0.0018
5805 Penicillin-binding protein 1A ponA 0.0018
6185 Penicillin-binding protein 1A mrcA 0.0018
6799 Penicillin-binding protein 1A pbpA 0.0018
159 Penicillin-binding protein 2B penA 0.0018
6121 Penicillin-binding protein 2B penA 0.0018
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0018
88 Retinoic acid receptor RXR-beta RXRB 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
162 Retinoic acid receptor gamma-1 RARG 0.0017
1648 Elastin ELN 0.0017
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
738 Monocarboxylate transporter 1 SLC16A1 0.0016
1830 5'-nucleotidase NT5E 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
1243 Cathepsin D CTSD 0.0016
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0016
3601 Dihydropteroate synthase 1 folP1 0.0016
3807 Dihydropteroate synthase 1 folP1 0.0016
3808 Dihydropteroate synthase 2 folP2 0.0016
427 Substance-P receptor TACR1 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2981 Phospholipase A2, membrane associated PLA2G2A 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3913 Glutamic acid decarboxylase GAD65 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
29 Tubulin beta-1 chain TUBB1 0.0014
3086 Plasmepsin-2 Not Available 0.0014
54 Prothrombin F2 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0013
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0013
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0013
1268 Neuropeptide S receptor NPSR1 0.0013
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
165 FL cytokine receptor FLT3 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
6073 Potassium channel subfamily K member 9 KCNK9 0.0012
6072 Potassium channel subfamily K member 3 KCNK3 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0011
291 Nitric-oxide synthase, endothelial NOS3 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
4237 50S ribosomal protein L22 rplV 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
1864 RET proto-oncogene RET 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.001
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.001
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.001
6085 Fatty acid-binding protein, intestinal FABP2 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
345 Plasma retinol-binding protein RBP4 0.001
144 Hemoglobin subunit alpha HBA1 0.001
760 Fibroblast growth factor 1 FGF1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
2207 Rhodopsin RHO 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
3221 Cytochrome c4 cc4 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
1262 Corticotropin-lipotropin POMC 0.0008
1341 Histamine H3 receptor HRH3 0.0008
6459 Glycodelin PAEP 0.0008
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2802 Endoglucanase G celCCG 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
4773 Deoxycytidine kinase DCK 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
1630 Integrin beta-2 ITGB2 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0004
24 Thymidylate synthase TMP1 0.0004
359 Thymidylate synthase TYMS 0.0004
2626 Thymidylate synthase thyA 0.0004
2729 Thymidylate synthase thyA 0.0004
5352 Thymidylate synthase THYA 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
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