Identification | |||||||
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Name | Papaverine | ||||||
Accession Number | DB01113 (APRD00628, DB07725) | ||||||
Type | small molecule | ||||||
Description | An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels. [PubChem] | ||||||
Structure |
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Categories (*) | |||||||
Molecular Weight | 339.385 | ||||||
Groups | approved | ||||||
Monoisotopic Weight | 339.147058165 | ||||||
Pharmacology | |||||||
Indication | For the treatment of impotence and vasospasms. | ||||||
Mechanism of action | Perhaps by its direct vasodilating action on cerebral blood vessels, Papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy. | ||||||
Absorption | Not Available | ||||||
Protein binding | ~90% | ||||||
Biotransformation | Not Available | ||||||
Route of elimination | Not Available | ||||||
Toxicity | Not Available | ||||||
Affected organisms |
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Interactions | |||||||
Drug Interactions |
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Food Interactions | Not Available |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |
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Name | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
Gene Name | PDE4B |
Pharmacological action | yes |
Actions | inhibitor |
References |
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DTHybrid score | Not Available |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | |
Name | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
Gene Name | PDE10A |
Pharmacological action | unknown |
Actions | inhibitor |
References |
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DTHybrid score | Not Available |